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Accessibility analyses are important for public transit (PT) planning, as they reveal possible deficits in PT services. Since such accessibility analyses are highly time-dependent, the Modifiable Temporal Unit Problem (MTUP) should be considered. In this context, one approach is to calculate accessibility continuously for an entire day and aggregate it appropriately. However, this approach is complex and computationally intensive and is therefore rarely, if ever, applied. Instead, practitioners and researchers rely on simplified methods without considering temporal effects in detail. This paper bridges this gap by developing a simple yet representative method to account for the temporal variability of PT services. For this purpose, we calculate and compare PT accessibility for different time windows and through different aggregation methods for Germany. The results show that PT analyses between 9–11 a.m. were most representative. Alternatively, the time windows between 7–9 a.m. and between 1–3 p.m. adequately reflected accessibility. The median was suitable for aggregating individual time intervals into a representative value for the PT service throughout a day, while the maximum or mean value distorted the results. For practical planning purposes, we therefore recommend using the 9–11 a.m. time window. [ABSTRACT FROM AUTHOR]

This essay explores circular compositions in medieval and early modern art. Delving into the intersection of religious, philosophical, and scientific ideas, the text examines the prevalence of circular depictions in medieval and early modern aesthetics. Utilizing an interdisciplinary approach, the author draws from primary Hermetic and Neoplatonic sources, providing four reasons for this preference. Firstly, this essay explores the scientific understanding of the shape of the universe, planets, and stars. The second reason delves into the psychological, symbolic, and geometric aspects associated with circular compositions, connecting them to Christian cosmological diagrams and symbolism in the visual arts. Furthermore, the essay investigates the conceptualisation of the universe as a mirror reflecting the divine, emphasising the role of beauty in religious art. The essay concludes by examining the visual culture of medieval and early modern periods, tracing the evolution of circular representations from Roman coins and shields to illuminated manuscripts and paintings. The article sheds light on a hitherto underexplored aspect of medieval and early modern cultures, despite its significance in shaping symbolism and organizing iconographic programs within these periods. [ABSTRACT FROM AUTHOR]

(1) Background: The radial forearm flap (RFF) has evolved as the flap of choice for intraoral mucosal reconstructions, providing thin and pliable skin with a safe blood supply. Perforator flaps such as the anterolateral thigh (ALT) flap are increasingly being discussed for the same applications. (2) Methods: Patient history, treatment details, and outcome of 12 patents with moderate to extended defects of the lip and/or nose area that were reconstructed by a folded radial forearm flap were retrospectively evaluated for oncologic and functional outcomes. (3) Results: The mean oncologic and functional follow-up were 21.1 (min. 3.8; max. 83.3) and 31.2 (min. 6; max. 96) months, respectively. All flaps survived without revision. In eight cases, major lip defects were reconstructed by an RFF; in six patients, the palmaris longus tendon was included for lip suspension. The functional results in terms of eating, drinking, and mouth opening were good in five cases, while three patients were graded as fair due to moderate drooling. In seven cases, the major parts of the nose were reconstructed with two good and five fair (nostril constriction in three cases) functional results. (4) Conclusions: The folded RFF remains a unique free flap option for complex three-dimensional lip and nose reconstructions in terms of flexibility, versatility, and robustness. [ABSTRACT FROM AUTHOR]

Transferred naïve CD8 SP + sp CD45.1 SP + sp HA-specific T cells behaved similar to endogenous CD8 SP + sp CD45.2 SP + sp T cells (Fig. (b) CD4, CD8, and FoxP3 and (d) CD8, CD44, and PD-1. e Representative staining for CD8, PD-1, and Ki67 14 and 21 days after tumor induction. f Quantitative analysis at the same time points. The fate of naive tumor-specific T cells (CD8 SP + sp CD45.1 SP + sp HA-specific T cells) adoptively transferred 10 days after tumor induction was also investigated. While effector CD8 SP + sp and CD4 SP + sp Foxp3 SP - sp T cells were found almost exclusively in the tumors of treated mice, CD4 SP + sp Foxp3 SP + sp regulatory T cells (Tregs) were present in the tumors of both mouse groups (Fig. [Extracted from the article]