1. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
- Author
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Miroslav Novaković, Danka Bukvicki, Tatjana Ilic-Tomic, Milan Veljić, Yoshinori Asakawa, Boban Andjelkovic, and Vele Tešević
- Subjects
phenanthrene ,Hepatophyta ,riccardins ,natural products ,Stereochemistry ,Lung cancer cell line ,Pharmaceutical Science ,01 natural sciences ,Lunularia cruciata ,riccardin G ,Analytical Chemistry ,chemistry.chemical_compound ,liverwort ,quinone moieties ,Drug Discovery ,bisbibenzyls ,Ic50 values ,Bibenzyl ,Cytotoxic T cell ,Humans ,perrottetin and riccardin structures ,structures of compounds ,cytotoxic activity ,Pharmacology ,Biological Products ,biology ,010405 organic chemistry ,Organic Chemistry ,cyclic analogues ,biology.organism_classification ,dihydrophenanthrene ,Antineoplastic Agents, Phytogenic ,spectroscopic data ,perrottetins ,acyclic bisbibenzyls ,3. Good health ,0104 chemical sciences ,Quinone ,lung cancer ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,A549 Cells ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Lunularia ,Cruciata - Abstract
Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively. Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3097]
- Published
- 2019