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Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
- Source :
- Journal of Natural Products
- Publication Year :
- 2019
-
Abstract
- Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively. Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3097]
- Subjects :
- phenanthrene
Hepatophyta
riccardins
natural products
Stereochemistry
Lung cancer cell line
Pharmaceutical Science
01 natural sciences
Lunularia cruciata
riccardin G
Analytical Chemistry
chemistry.chemical_compound
liverwort
quinone moieties
Drug Discovery
bisbibenzyls
Ic50 values
Bibenzyl
Cytotoxic T cell
Humans
perrottetin and riccardin structures
structures of compounds
cytotoxic activity
Pharmacology
Biological Products
biology
010405 organic chemistry
Organic Chemistry
cyclic analogues
biology.organism_classification
dihydrophenanthrene
Antineoplastic Agents, Phytogenic
spectroscopic data
perrottetins
acyclic bisbibenzyls
3. Good health
0104 chemical sciences
Quinone
lung cancer
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
chemistry
A549 Cells
Molecular Medicine
Drug Screening Assays, Antitumor
Lunularia
Cruciata
Subjects
Details
- ISSN :
- 15206025
- Volume :
- 82
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of natural products
- Accession number :
- edsair.doi.dedup.....4861f47f9ca787dc694fa8240380bb90