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Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata

Authors :
Miroslav Novaković
Danka Bukvicki
Tatjana Ilic-Tomic
Milan Veljić
Yoshinori Asakawa
Boban Andjelkovic
Vele Tešević
Source :
Journal of Natural Products
Publication Year :
2019

Abstract

Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively. Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3097]

Details

ISSN :
15206025
Volume :
82
Issue :
4
Database :
OpenAIRE
Journal :
Journal of natural products
Accession number :
edsair.doi.dedup.....4861f47f9ca787dc694fa8240380bb90