1. Priorities for future research into asthma diagnostic tools: A PAN-EU consensus exercise from the European asthma research innovation partnership (EARIP)
- Author
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Garcia-Marcos, L, Edwards, J, Kennington, E, Aurora, P, Baraldi, E, Carraro, S, Gappa, M, Louis, R, Moreno-Galdo, A, Peroni, DG, Pijnenburg, M, Priftis, KN, Sanchez-Solis, M, Schuster, A, Walker, S, Blakey, J, Compton, C, Fleming, L, Fowler, S, Gaillard, E, Gibson, F, Glenn Crater, G, Niven, R, Roberts, A, Ryan, D, Seppala, U, Usmani, O, Van der Schee, M, Van Sont, J, and Pediatrics
- Subjects
medicine.medical_specialty ,Consensus ,Allergy ,diagnosis ,Immunology ,MEDLINE ,Delphi method ,Physical examination ,asthma, children, lung function, inflammation, diagnosis ,Diagnostic tools ,03 medical and health sciences ,0302 clinical medicine ,children ,medicine ,Immunology and Allergy ,Humans ,Metabolomics ,030212 general & internal medicine ,Lung function ,Asthma ,medicine.diagnostic_test ,business.industry ,Health Priorities ,Research ,lung function ,medicine.disease ,Prognosis ,respiratory tract diseases ,Respiratory Function Tests ,Europe ,030228 respiratory system ,1117 Public Health And Health Services ,Breath Tests ,inflammation ,1107 Immunology ,Family medicine ,General partnership ,Objective test ,business ,Biomarkers - Abstract
The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective tests either to confirm the diagnosis or to discriminate between different types of asthma. This consensus exercise reviews the state of the art in asthma diagnosis to identify opportunities for future investment based on the likelihood of their successful development, potential for widespread adoption and their perceived impact on asthma patients. Using a two-stage e-Delphi process and a summarizing workshop, a group of European asthma experts including health professionals, researchers, people with asthma and industry representatives ranked the potential impact of research investment in each technique or tool for asthma diagnosis and monitoring. After a systematic review of the literature, 21 statements were extracted and were subject of the two-stage Delphi process. Eleven statements were scored 3 or more and were further discussed and ranked in a face-to-face workshop. The three most important diagnostic/predictive tools ranked were as follows: “New biological markers of asthma (eg genomics, proteomics and metabolomics) as a tool for diagnosis and/or monitoring,” “Prediction of future asthma in preschool children with reasonable accuracy” and “Tools to measure volatile organic compounds (VOCs) in exhaled breath.”.
- Published
- 2018