1. Relative potency of tyrosol in the treatment of endotoxin-induced uveitis in rats
- Author
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Kazuaki Sato, Yuko Mihara, Yohei Yamashita, Kazutaka Kanai, Naoyuki Itoh, and Yuya Kimura
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Necrosis ,Clinical Pathology ,Lipopolysaccharide ,Prednisolone ,Pharmacology ,anti-inflammatory potency ,PSL ,Antioxidants ,Dinoprostone ,endotoxin-induced uveitis ,Uveitis ,03 medical and health sciences ,chemistry.chemical_compound ,medicine ,Animals ,Inflammation ,General Veterinary ,Tumor Necrosis Factor-alpha ,Anti-Inflammatory Agents, Non-Steroidal ,Phenylethyl Alcohol ,medicine.disease ,Note ,Rats ,Tyrosol ,Endotoxins ,030104 developmental biology ,chemistry ,Rats, Inbred Lew ,Histopathology ,Tumor necrosis factor alpha ,medicine.symptom ,medicine.drug ,tyrosol - Abstract
Tyrosol (Tyr) is a natural phenolic antioxidant with diverse biological activities. We compared the anti-inflammatory effects of intravenously administered Tyr versus prednisolone (PSL) in an endotoxin-induced uveitis (EIU) rat model. Intravenous administration of 100 mg/kg Tyr was performed 2 hr before, simultaneously and 2 hr after lipopolysaccharide (LPS) injection. Tyr treatment was associated with decreased inflammatory cell number, protein concentration, tumor necrosis factor (TNF)-α, PGE2 and NO levels in AqH and improvements in histopathologic evidence of EIU in ocular tissue at 24 hr after LPS injection. 100 mg/kg Tyr and 1 mg/kg PSL (administered on the same schedule as Tyr) had comparable anti-inflammatory effects. Taken together, Tyr may represent a promising therapeutic agent for the management of intraocular inflammatory diseases.
- Published
- 2016