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Relative potency of tyrosol in the treatment of endotoxin-induced uveitis in rats
- Source :
- The Journal of Veterinary Medical Science
- Publication Year :
- 2016
-
Abstract
- Tyrosol (Tyr) is a natural phenolic antioxidant with diverse biological activities. We compared the anti-inflammatory effects of intravenously administered Tyr versus prednisolone (PSL) in an endotoxin-induced uveitis (EIU) rat model. Intravenous administration of 100 mg/kg Tyr was performed 2 hr before, simultaneously and 2 hr after lipopolysaccharide (LPS) injection. Tyr treatment was associated with decreased inflammatory cell number, protein concentration, tumor necrosis factor (TNF)-α, PGE2 and NO levels in AqH and improvements in histopathologic evidence of EIU in ocular tissue at 24 hr after LPS injection. 100 mg/kg Tyr and 1 mg/kg PSL (administered on the same schedule as Tyr) had comparable anti-inflammatory effects. Taken together, Tyr may represent a promising therapeutic agent for the management of intraocular inflammatory diseases.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Necrosis
Clinical Pathology
Lipopolysaccharide
Prednisolone
Pharmacology
anti-inflammatory potency
PSL
Antioxidants
Dinoprostone
endotoxin-induced uveitis
Uveitis
03 medical and health sciences
chemistry.chemical_compound
medicine
Animals
Inflammation
General Veterinary
Tumor Necrosis Factor-alpha
Anti-Inflammatory Agents, Non-Steroidal
Phenylethyl Alcohol
medicine.disease
Note
Rats
Tyrosol
Endotoxins
030104 developmental biology
chemistry
Rats, Inbred Lew
Histopathology
Tumor necrosis factor alpha
medicine.symptom
medicine.drug
tyrosol
Subjects
Details
- ISSN :
- 13477439
- Volume :
- 78
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- The Journal of veterinary medical science
- Accession number :
- edsair.doi.dedup.....2be76e802b92ef26194429b549368f10