11 results on '"Yu-Xin Yue"'
Search Results
2. A general supramolecular adjuvant for pesticides based on <scp>host–guest</scp> recognition
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Rong Ma, Yue‐Dan Zheng, Han‐Wen Tian, Meng‐Meng Chen, Yu‐Xin Yue, Qiang Bian, Hua‐Bin Li, and Dong‐Sheng Guo
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Insect Science ,General Medicine ,Agronomy and Crop Science - Published
- 2023
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3. Design of Calixarene‐Based ICD Inducer for Efficient Cancer Immunotherapy
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Zhanzhan Zhang, Yu‐Xin Yue, Qiushi Li, Ying Wang, Xueyao Wu, Xue Li, Hua‐Bin Li, Linqi Shi, Dong‐Sheng Guo, and Yang Liu
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Biomaterials ,Electrochemistry ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials - Published
- 2023
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4. Supramolecular Radiosensitizer Based on Hypoxia-Responsive Macrocycle
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Xiaoxue Hou, Yu‐Xuan Chang, Yu‐Xin Yue, Ze‐Han Wang, Fei Ding, Zhi‐Hao Li, Hua‐Bin Li, Yicheng Xu, Xianglei Kong, Fan Huang, Dong‐Sheng Guo, and Jianfeng Liu
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Radiation-Sensitizing Agents ,Macrocyclic Compounds ,General Chemical Engineering ,Cell Line, Tumor ,Neoplasms ,General Engineering ,General Physics and Astronomy ,Medicine (miscellaneous) ,Humans ,General Materials Science ,Hypoxia ,Biochemistry, Genetics and Molecular Biology (miscellaneous) - Abstract
Radiotherapy (RT) has been viewed as one of the most effective and extensively applied curatives in clinical cancer therapy. However, the radioresistance of tumor severely discounts the radiotherapy outcomes. Here, an innovative supramolecular radiotherapy strategy, based on the complexation of a hypoxia-responsive macrocycle with small-molecule radiosensitizer, is reported. To exemplify this tactic, a carboxylated azocalix[4]arene (CAC4A) is devised as molecular container to quantitatively package tumor sensitizer banoxantrone dihydrochloride (AQ4N) through reversible host-guest interaction. Benefited from the selective reduction of azo functional groups under hypoxic microenvironment, the supramolecular prodrug CAC4A•AQ4N exhibits high tumor accumulation and efficient cellular internalization, thereby significantly amplifying radiation-mediated tumor destruction without appreciable systemic toxicity. More importantly, this supramolecular radiotherapy strategy achieves an ultrahigh sensitizer enhancement ratio (SER) value of 2.349, which is the supreme among currently reported noncovalent-based radiosensitization approach. Further development by applying different radiosensitizing drugs can make this supramolecular strategy become a general platform for boosting therapeutic effect in cancer radiotherapies, tremendously promising for clinical translation.
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- 2021
5. Geochronology and petrogenesis of volcanic rocks in the Laurani epithermal Au–Ag–Cu deposit, northern Bolivian Altiplano
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Fei Liu, Run-Sheng Han, Dong Zhao, Shu-Ming Wen, Wen-Yao Li, Jia-Sheng Wang, Li Lei, and Yu-Xin-Yue Guo
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Geology ,Earth-Surface Processes - Published
- 2022
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6. A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy
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Xiaoxue Hou, Jianfeng Liu, Yong Kong, Dong-Sheng Guo, Hua-Bin Li, Muhammad Raza Shah, Fan Huang, Fan Yang, Tian-Xing Zhang, and Yu-Xin Yue
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photothermal therapy ,Chemistry ,hypoxia ,IR780 ,Supramolecular chemistry ,technology, industry, and agriculture ,Medicine (miscellaneous) ,macromolecular substances ,Hypoxia (medical) ,Photothermal therapy ,Theranostic Nanomedicine ,supramolecular chemistry ,Mice ,Photochemotherapy ,Cell Line, Tumor ,Neoplasms ,medicine ,Biophysics ,Animals ,calixarene ,medicine.symptom ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Research Paper - Abstract
Photothermal agents (PTAs) based on organic small-molecule dyes emerge as promising theranostic strategy in imaging and photothermal therapy (PTT). However, hydrophobicity, photodegradation, and low signal-to-noise ratio impede their transformation from bench to bedside. In this study, a novel supramolecular PTT formulation by a stimuli-responsive macrocyclic host is prepared to overcome these obstacles of organic small-molecule PTAs. Methods: Sulfonated azocalix[4]arene (SAC4A) was synthesized as a hypoxia-responsive macrocyclic host. Taking IR780 as an example, the supramolecular nanoformulation IR780@SAC4A was constructed by grinding method, and its solubility, photostability, and photothermal conversion were evaluated. The hypoxia tumor-selective imaging and supramolecular PTT of IR780@SAC4A were further evaluated in vitro and in vivo. Results: IR780@SAC4A is capable of enhancing the solubility, photostability, and photothermal conversion of IR780 significantly, which achieve this supramolecular formulation with good imaging-guided PTT efficacy in vitro and in vivo. Conclusions: This study demonstrates that the supramolecular PTT strategy is a promising cancer theranostic method. Moreover, this supramolecular approach is applicative to construct kinds of supramolecular PTAs, opening a general avenue for extending smart PTT formulations.
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- 2021
7. A Supramolecular Antidote to Macromolecular Toxins Prepared through Coassembly of Macrocyclic Amphiphiles
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Dong-Sheng Guo, Yu-Xin Yue, Yu-Chen Pan, Hua-Bin Li, and Xin-Yue Hu
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Materials science ,Cell Survival ,Macromolecular Substances ,medicine.medical_treatment ,Antidotes ,Supramolecular chemistry ,Spider Venoms ,Hemolysis ,Melittin ,chemistry.chemical_compound ,Mice ,Intensive care ,Detoxification ,Calixarene ,Amphiphile ,medicine ,Animals ,Humans ,General Materials Science ,Antidote ,Cytotoxicity ,Cyclodextrins ,Mechanical Engineering ,Cell Membrane ,technology, industry, and agriculture ,Combinatorial chemistry ,Melitten ,HEK293 Cells ,chemistry ,Liver ,Mechanics of Materials ,lipids (amino acids, peptides, and proteins) ,Antimicrobial Cationic Peptides - Abstract
Poisoning is a leading cause of admission to medical emergency departments and intensive care units. Supramolecular detoxification, which involves injecting supramolecular receptors that bind with toxins to suppress their biological activity, is an emerging strategy for poisoning treatment; it has few requirements and a broad application scope. However, it is still a formidable challenge to design supramolecular therapeutic materials as an antidote to macromolecular toxins, because the large size, flexible conformation, and presence of multiple and diverse binding sites of biomacromolecules hinder their recognition. Herein, a supramolecular antidote to macromolecular toxins is developed through the coassembly of macrocyclic amphiphiles, relying on heteromultivalent recognition between the coassembled components and toxic macromolecules. The coassembly of amphiphilic cyclodextrin and calixarene strongly and selectively captures melittin, a toxin studied herein; this imparts various therapeutic effects such as inhibiting the interactions of melittin with cell membranes, alleviating melittin cytotoxicity and hemolytic toxicity, reducing the mortality rate of melittin-poisoned mice, and mitigating damage to major organs. The use of the proposed antidote overcomes the limitation of supramolecular detoxification applicability to only small-molecular toxins. The antidote can also detoxify other macromolecular toxins as long as selective and strong binding is achieved because of the coassembling tunability.
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- 2021
8. Promoting Tumor Accumulation of Anticancer Drugs by Hierarchical Carrying of Exogenous and Endogenous Vehicles
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Yu-Xin Yue, Zhanzhan Zhang, Ze-Han Wang, Rong Ma, Meng-Meng Chen, Fei Ding, Hua-Bin Li, Juan-Juan Li, Linqi Shi, Yang Liu, and Dong-Sheng Guo
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General Medicine - Published
- 2022
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9. Macrocyclic-Amphiphile-Based Self-Assembled Nanoparticles for Ratiometric Delivery of Therapeutic Combinations to Tumors
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Juan-Juan Li, Wen-Chao Geng, Xiang-Lei Kong, Linqi Shi, Xinzhi Zhao, Yang Liu, Lina Xu, Ying Wang, Yu Zhao, Yu-Xin Yue, Zhanzhan Zhang, Dong-Sheng Guo, and Yadan Zheng
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Drug ,Materials science ,Macrocyclic Compounds ,media_common.quotation_subject ,Nanoparticle ,Antineoplastic Agents ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Drug synergism ,Self assembled ,In vivo ,Amphiphile ,General Materials Science ,media_common ,Drug Carriers ,Mechanical Engineering ,Combination chemotherapy ,021001 nanoscience & nanotechnology ,Controlled release ,Combined Modality Therapy ,0104 chemical sciences ,Mechanics of Materials ,Biophysics ,Nanoparticles ,0210 nano-technology ,Hydrophobic and Hydrophilic Interactions - Abstract
Combination chemotherapy refers to the use of multiple drugs to treat cancer. In this therapy, the optimal ratio of the drugs is essential to achieve drug synergism and the desired therapeutic effects. However, most delivery strategies are unable to precisely control the ratio of the drugs during the drug loading and delivery processes, resulting in inefficient synergy and unpredictable efficacy. Herein, a macrocyclic-amphiphile-based self-assembled nanoparticle (MASN) that achieves precise loading and ratiometric delivery of therapeutic combinations is presented. By integrating multiple macrocyclic cavities within a single nanoparticle, the MASN can load multiple drug molecules via the host-guest interaction, and the ratio of the drugs loaded can be predicted with their initial concentrations and characteristic binding affinity. Moreover, MASNs are readily degraded under a hypoxic microenvironment, allowing spontaneous release of the drugs upon reaching tumor tissues. With precise drug loading and controlled release mechanisms, MASNs achieve ratiometric delivery of multiple commercial drugs to tumors, thereby achieving optimal anti-tumor effects. Since the optimal drug ratio of a therapeutic combination can be quickly determined in vitro, MASNs can translate this optimal ratio to the therapeutic benefits in vivo, providing a potential platform for the rapid development of effective combination cancer therapies involving multiple drugs.
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- 2021
10. Noninvasive and Individual‐Centered Monitoring of Uric Acid for Precaution of Hyperuricemia via Optical Supramolecular Sensing
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Yaping Zhang, Huijuan Yu, Shiwei Chai, Xin Chai, Luyao Wang, Wen‐Chao Geng, Juan‐Juan Li, Yu‐Xin Yue, Dong‐Sheng Guo, and Yuefei Wang
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Gout ,General Chemical Engineering ,General Engineering ,Humans ,General Physics and Astronomy ,Medicine (miscellaneous) ,General Materials Science ,Hyperuricemia ,Kidney ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Uric Acid - Abstract
Characterized by an excessively increased uric acid (UA) level in serum, hyperuricemia induces gout and also poses a great threat to renal and cardiovascular systems. It is urgent and meaningful to perform early warning by noninvasive diagnosis, thus conducing to blockage of disease aggravation. Here, guanidinocalix[5]arene (GC5A) is successfully identified from the self-built macrocyclic library to specifically monitor UA from urine by the indicator displacement assay. UA is strongly bound to GC5A at micromolar-level, while simultaneously excluding fluorescein (Fl) from the GC5A·Fl complex in the "switch-on" mode. This method successfully differentiates patients with hyperuricemia from volunteers except for those with kidney dysfunction and targets a volunteer at high risk of hyperuricemia. In order to meet the trend from hospital-centered to individual-centered testing, visual detection of UA is studied through a smartphone equipped with a color-scanning feature, whose adaptability and feasibility are demonstrated in sensing UA from authentic urine, leading to a promising method in family-centered healthcare style. A high-throughput and visual detection method is provided here for alarming hyperuricemic by noninvasive diagnosis.
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- 2022
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11. A General Hypoxia‐Responsive Molecular Container for Tumor‐Targeted Therapy
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Yang Liu, Dong-Sheng Guo, Tian-Xing Zhang, Xin-Yue Hu, Linqi Shi, Yu-Xin Yue, Fan Huang, and Zhanzhan Zhang
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Drug Carriers ,Materials science ,Mechanical Engineering ,Supramolecular chemistry ,Nanotechnology ,02 engineering and technology ,Prodrug ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Tumor targeted ,Drug Liberation ,Solubility ,Mechanics of Materials ,Cell Line, Tumor ,Drug delivery ,Humans ,Tumor Hypoxia ,General Materials Science ,Molecular Targeted Therapy ,Calixarenes ,0210 nano-technology - Abstract
Enhanced drug delivery can improve the therapeutic efficacy of drugs and help overcome side effects. However, many reported drug-delivery systems are too complex and irreproducible for practical use. In this work, the design of a hypoxia-responsive molecular container based on calixarene, called CAC4A, which presents a significant advance in practical, hypoxia-targeted drug-delivery, is reported. CAC4A enables a wide variety of clinical drugs to be quantitatively loaded to improve their solubility and stability, as well as enable the administration of reduced doses. Furthermore, as a result of its azo functional groups, which are sensitive to reduction within a hypoxic environment, it is possible to achieve tumor-targeted drug-release with reduced side effects. CAC4A fulfils all essential requirements for a drug-delivery system in addition to multiple advantages, including facile preparation, well-defined molecular weight, and structure, and universal applicability. Such features collectively enable supramolecular prodrugs to be formulated simply and reproducibly, with potential for bench-to-bedside translation. Moreover, CAC4A is amenable to other therapy modalities and can be facilely decorated with functional groups and hybridized with nanomaterials, providing ample possibilities for its role in future drug-delivery systems.
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- 2020
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