15 results on '"Vassallo, V."'
Search Results
2. Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?
- Author
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Stellavato A, Restaino OF, Vassallo V, Finamore R, Ruosi C, Cassese E, De Rosa M, Schiraldi C., Stellavato, A, Restaino, Of, Vassallo, V, Finamore, R, Ruosi, C, Cassese, E, De Rosa, M, and Schiraldi, C.
- Published
- 2019
3. Shape analysis techniques for the Ayia Irini case study
- Author
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Andreas Scalas, Vassallo V., Mortara M., Spagnuolo M., and Hermon S.
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11. Sustainability ,0202 electrical engineering, electronic engineering, information engineering ,Computing methodologies: Shape analysis ,Shape representations ,020207 software engineering ,02 engineering and technology ,Computing methodologies ,Shape analysis ,Mesh geometry models - Abstract
The typical approach for archaeological analysis is mainly qualitative and, as such, subjective. Even when some measures are reported in the documentation of artefacts, they are often approximate or ambiguous. Conversely, the quantitative approach is based on objective metrics to produce replicable results and, coupled with digital tools, can assist the qualitative analysis in archaological research with no risk of damage. In this paper, we present a geometric-quantitative approach for the analysis of archaeological finds and the preliminary results of an ongoing joint research project of two doctoral students within the frame of the EU GRAVITATE project., Eurographics Workshop on Graphics and Cultural Heritage, Virtual Archaeology, 255, 258, Andreas Scalas, Valentina Vassallo, Michela Mortara, Michela Spagnuolo, and Sorin Hermon, CCS Concepts: Computing methodologies --> Shape analysis; Mesh geometry models; Shape representations
- Published
- 2018
- Full Text
- View/download PDF
4. Improving the diagnostic accuracy of depression in older persons: the Depression in the Aged Female National Evaluation cluster randomized trial
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Lattanzio F, Di Bari M, Sgadari A, Baccini M, Ercolani S, Rengo F, Senin U, Bernabei R, Marchionni N, Cherubini A, Depression in the Aged Female National Evaluation Study Group: Rozzini R, Cassinadri A, Ricci A, Valenti G, Falzoi C, Grimaldi W, Putzu PF, Porceddu C, Coghe F, Matta M, Manca E, Mereu MR, Viale D, Antonelli Incalzi R, Ciaburri M, Di Palma R, Pagano F, Zamboni V, Borghesi T, Crovetti B, Inzitari M, Masotti G, Mossello E, Sarcone E, Sforza G, Cerqua R, Califano M, Pilotto A, Cascavilla L, Paris F, Salvioli G, Badini I, Foroni M, Sabbatici F, Salsi F, Abate G, Abate M, D'Attilio A, Di Iorio A, Fogliatta M, Zanatta A, Gasparini R, Gasparini G, Pedrazzoli R, Tobaldini C, Biagini C, Bencini F, Caleri V, Cantini C, Cipriani C, Luzzi C, Tonon E, Benedetti C, Ferretti R, Macchiarulo C, ABETE, PASQUALE, Mazzella F, Pollice S, Vassallo V, Di Stefano F, Gulizia G, Mazzarella R., Lattanzio, F, Di Bari, M, Sgadari, A, Baccini, M, Ercolani, S, Rengo, F, Senin, U, Bernabei, R, Marchionni, N, Cherubini, A, Depression in the Aged Female National Evaluation Study Group: Rozzini, R, Cassinadri, A, Ricci, A, Valenti, G, Falzoi, C, Grimaldi, W, Putzu, Pf, Porceddu, C, Coghe, F, Matta, M, Manca, E, Mereu, Mr, Viale, D, Antonelli Incalzi, R, Ciaburri, M, Di Palma, R, Pagano, F, Zamboni, V, Borghesi, T, Crovetti, B, Inzitari, M, Masotti, G, Mossello, E, Sarcone, E, Sforza, G, Cerqua, R, Califano, M, Pilotto, A, Cascavilla, L, Paris, F, Salvioli, G, Badini, I, Foroni, M, Sabbatici, F, Salsi, F, Abate, G, Abate, M, D'Attilio, A, Di Iorio, A, Fogliatta, M, Zanatta, A, Gasparini, R, Gasparini, G, Pedrazzoli, R, Tobaldini, C, Biagini, C, Bencini, F, Caleri, V, Cantini, C, Cipriani, C, Luzzi, C, Tonon, E, Benedetti, C, Ferretti, R, Macchiarulo, C, Abete, Pasquale, Mazzella, F, Pollice, S, Vassallo, V, Di Stefano, F, Gulizia, G, and Mazzarella, R.
- Abstract
Objectives: To evaluate whether a training intervention can improve the ability of geriatricians to recognize depression in older persons. Design: Multicenter, cluster randomized clinical trial. Setting: Fourteen geriatric outpatient clinics in Italy, each representing the unit of randomization. Participants: After training, a total of 1,914 outpatients aged 65 years and older in both arms, not on antidepressant at entry, were blindly evaluated by the clinic geriatrician, in charge of routine clinical management, and by a field researcher, who formally diagnosed depression by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), taken as the criterion standard. Intervention: After randomization, geriatricians belonging to the intervention arm were assigned to receive a residential 3-day educational program on depression. Those in the control arm received a generic course on disease management in elderly people. Measurements: Sensitivity and specificity of the diagnosis of depression made by geriatricians, compared with the DSM-IV diagnosis. Results: Sensitivity and specificity were significantly higher in trained than in untrained geriatricians (49 vs 35% and 91 vs 88%, respectively; P=.002 in marginal regression models). Effectiveness of training was confirmed, adjusting for age, sex, and cognitive performance (P=.02). Conclusion: The ability of geriatricians to diagnose depression in older outpatients can be improved with a specific training intervention. Improvement of diagnostic performance might translate into more-appropriate clinical management.
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- 2009
5. Progetto Ca'Tron: dalle indagini sul campo alla ricostruzione del paesaggio
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Cerato, I. and Vassallo, V.
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Ca'_Tron ,Archeologia_virtuale ,Paesaggio - Published
- 2010
6. Metodologia per la ricostruzione 3D del paesaggio archeologico
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Moro, A. and Vico, L., Vassallo, V.
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Metodologie ,Paesaggio ,3D - Published
- 2007
7. From relief to the 3D Reconstruction: the Methodology
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Moro, A., Vassallo, V., and Vico, L.
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Rilievo_3D ,Modellazione_3D ,Metodologia - Published
- 2007
8. Modern Documentation to Communicate the Cultural heritage: the Via Flaminia Project
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Vico Lopez, L., Moro, A., and Vassallo, V.
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Patrimonio Culturale ,Comunicazione - Published
- 2007
9. The Importance of Relief and the Sources to Interpret and Communicate the Cultural Heritage
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Vassallo, V., Vico, L., and Moro, A.
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Patrimonio Culturale ,Conoscenza ,Comunicazione - Published
- 2006
10. Molecular Fingerprint of Human Pathological Synoviocytes in Response to Extractive Sulfated and Biofermentative Unsulfated Chondroitins
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Valentina Vassallo, Antonietta Stellavato, Rosita Russo, Donatella Cimini, Mariangela Valletta, Alberto Alfano, Paolo Vincenzo Pedone, Angela Chambery, Chiara Schiraldi, Vassallo, V., Stellavato, A., Russo, R., Cimini, D., Valletta, M., Alfano, A., Pedone, P. V., Chambery, A., and Schiraldi, C.
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intracellular proteomic ,Inorganic Chemistry ,extractive chondroitin sulfate ,Organic Chemistry ,General Medicine ,Physical and Theoretical Chemistry ,Molecular Biology ,human primary synoviocyte ,human primary synoviocytes ,Spectroscopy ,Catalysis ,biofermentative unsulfated chondroitin ,Computer Science Applications - Abstract
Pharma-grade extractive chondroitin sulfate (CS) is widely used for osteoarthritis (OA) treatment. Recently, unsulfated biofermentative chondroitin (BC) proved positive effects in OA in vitro model. This study, based on primary pathological human synoviocytes, aimed to analyze, by a multiplex assay, a panel of OA-related biomarkers in response to short-term treatments with bovine (CSb), pig (CSp) and fish (CSf) chondroitins, in comparison to BC. As expected, all samples had anti-inflammatory properties, however CSb, CSf and especially BC affected more cytokines and chemokines. Based on these results and molecular weight similarity, CSf and BC were selected to further explore the synoviocytes’ response. In fact, Western blot analyses showed CSf and BC were comparable, downregulating OA-related biomarkers such as the proteins mTOR, NF-kB, PTX-3 and COMP-2. Proteomic analyses, performed by applying a nano-LC-MS/MS TMT isobaric labelling-based approach, displayed the modulation of both common and distinct molecules to chondroitin treatments. Thus, CSf and BC modulated the biological mediators involved in the inflammation cascade, matrix degradation/remodeling, glycosaminoglycans’ synthesis and cellular homeostasis. This study helps in shedding light on different molecular mechanisms related to OA disease that may be potentially affected not only by animal-source chondroitin sulfate but also by unsulfated biofermentative chondroitin.
- Published
- 2022
11. Effects of intravenous furosemide plus small-volume hypertonic saline solutions on markers of heart failure
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Alessandra Casuccio, Domenico Di Raimondo, Tiziana Di Chiara, Alba Mogavero, Carlo Maida, Maria Grazia Puleo, Antonino Tuttolomondo, Mario Daidone, Valerio Vassallo, Alessandro Del Cuore, Roberto Fonte, Antonella Ortello, Antonio Pinto, Tuttolomondo A., Maida C., Casuccio A., Di Raimondo D., Fonte R., Vassallo V., Puleo M.G., Di Chiara T., Mogavero A., Del Cuore A., Daidone M., Ortello A., and Pinto A.
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medicine.medical_specialty ,Settore MED/09 - Medicina Interna ,Acute decompensated heart failure ,medicine.medical_treatment ,furosemide, Heart failure, HSS, Biomarkers ,Gastroenterology ,Furosemide ,Internal medicine ,Original Research Articles ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,Original Research Article ,HSS ,Diuretics ,Saline ,Heart Failure ,Saline Solution, Hypertonic ,Ejection fraction ,Troponin T ,business.industry ,Therapeutic effect ,medicine.disease ,Hypertonic saline ,RC666-701 ,Heart failure ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,medicine.drug - Abstract
Aims: We sought to compare the effects of furosemide+hypertonic saline solution (HSS) treatment in patients with acute decompensated heart failure in comparison with furosemide alone and the response in a compensated state after an acute saline load with regard to serum levels of heart failure biomarkers. Methods and results: We enrolled 141 patients with acute decompensated heart failure with reduced ejection fraction admitted to our Internal Medicine ward from March 2017 to November 2019. A total of 73 patients were randomized to treatment with i.v. high-dose furosemide plus HSS, whereas 68 patients were randomized to i.v. high-dose furosemide alone. Patients treated with furosemide plus HSS compared with controls treated with furosemide alone showed a comparable degree of reduction in the serum levels of interleukin (IL)-6, soluble suppression of tumorigenicity 2 (sST2), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the ‘between-group’ analysis. Nevertheless, patients treated with high-dose furosemide+HSS showed significantly higher absolute delta values of IL-6 (2.3±1.2 vs. 1.7±0.9, P 
- Published
- 2021
12. Relationship between adherence to the Mediterranean Diet, intracerebral hemorrhage, and its location
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Carlo Maida, Mariachiara Velardo, Alessandra Casuccio, Vittoriano Della Corte, Valerio Vassallo, Valentina Arnao, Francesca Corpora, Giovanni Salamone, Antonino Tuttolomondo, Irene Simonetta, Rosaria Pecoraro, Anna Cirrincione, Vincenzo Restivo, Antonio Pinto, Domenico Di Raimondo, and Tuttolomondo A, Di Raimondo D, Casuccio A, Velardo M, Salamone G, Arnao V, Pecoraro R, Della Corte V, Restivo V, Corpora F, Maida C, Simonetta I, Cirrincione A, Vassallo V, Pinto A
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Male ,medicine.medical_specialty ,Time Factors ,Settore MED/09 - Medicina Interna ,Internal capsule ,Mediterranean diet ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Diet, Mediterranean ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Prevalence ,Humans ,Medicine ,In patient ,cardiovascular diseases ,Stroke ,Aged ,Cerebral Hemorrhage ,Retrospective Studies ,Aged, 80 and over ,Intracerebral hemorrhage ,Nutrition and Dietetics ,Proteinuria ,business.industry ,Retrospective cohort study ,Middle Aged ,Protective Factors ,Prognosis ,medicine.disease ,Italy ,Mediterranean Diet, ICH ,Female ,Diet, Healthy ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Risk Reduction Behavior ,Dyslipidemia - Abstract
INTRODUCTION: Although some authors evaluated the relationship between adherence to the Mediterranean Diet (MeDi) and both ischemic and hemorrhagic stroke, hemorrhagic stroke alone is not yet examined. AIMS: We conducted a retrospective study to evaluate the relationship between adherence to MeDi and intracerebral hemorrhage (ICH) and different locations of ICH (ganglionic/internal capsule, brainstem/cerebellum, or lobar). METHODS: We analyzed charts and collected data of all consecutive patients with ICH admitted to our Internal Medicine Ward from 2005 to 2014. A scale indicating the degree of adherence to the traditional MeDi Score was constructed. RESULTS: When compared with 100 subjects without ICH, 103 subjects with ICH had significantly higher mean values of LDL (91.1 ± 38.7 mg/dl vs. 79.2 ± 34.4 mg/dl; p = 0.031), triglycerides (118.9 ± 62.9 mg/dl vs. 101.6 ± 47.6 mg/dl; p = 0.026), and proteinuria (32.6 ± 50.0 mg/dl vs. 18.1 ± 39.6 mg/dl; p=0.024) and a significantly lower mean MeDi Score (3.9 ± 1.0 vs. 7.0 ± 1.4; p < 0.0001). In a multiple regression analysis, smoking, diastolic blood pressure (DBP), and the MeDi Score remained significantly associated with ICH. We also observed a significantly lower mean MeDi Score in the lobar location group when compared with the ganglionic/internal capsule group (4.3 ± 1.0 vs. 3.5 ± 0.9; p < 0.0005). DISCUSSION: Our findings regarding the higher prevalence of ICH in patients with lower adherence to MeDi may be related to the fact that patients with lower MeDi Score exhibit a worse cardiovascular risk profile with increased risk factors such as hypertension and dyslipidemia.
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- 2019
13. Timely Supplementation of Hydrogels Containing Sulfated or Unsulfated Chondroitin and Hyaluronic Acid Affects Mesenchymal Stromal Cells Commitment Toward Chondrogenic Differentiation
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Nicola Alessio, Antonietta Stellavato, Domenico Aprile, Donatella Cimini, Valentina Vassallo, Giovanni Di Bernardo, Umberto Galderisi, Chiara Schiraldi, Alessio, N., Stellavato, A., Aprile, D., Cimini, D., Vassallo, V., Di Bernardo, G., Galderisi, U., and Schiraldi, C.
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0301 basic medicine ,bio-fermentative unsulphated chondroitin ,Chondrocyte ,Cell therapy ,03 medical and health sciences ,chemistry.chemical_compound ,Cell and Developmental Biology ,0302 clinical medicine ,hyaluronic acid ,medicine ,Chondroitin ,Chondroitin sulfate ,Progenitor cell ,lcsh:QH301-705.5 ,differentiation chondrocytes regeneration ,Original Research ,Chemistry ,Mesenchymal stem cell ,Cell Biology ,Chondrogenesis ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,lcsh:Biology (General) ,030220 oncology & carcinogenesis ,extractive sulfated chondroitin ,Stem cell ,mesenchymal stromal cells ,Developmental Biology - Abstract
Mesenchymal stromal cells (MSCs) are currently used for cartilage cell therapy because of their well proven capacity to differentiate in chondrocytes. The advantage of MSC-based therapy is the possibility of producing a high number of chondrocytes for implants. The transplant procedure, however, has some limitations, since MSCs may produce non-functional chondrocytes. This limit has been challenged by cultivating MSC in media with hydrogels containing hyaluronic acid (HA), extractive chondroitin sulfate (CS), or bio-fermentative unsulphated chondroitin (BC) alone or in combination. Nevertheless, a clear study of the effect of glycosaminoglycans (GAGs) on chondrocyte differentiation is still lacking, especially for the newly obtained unsulfated chondroitin of biotechnological origin. Are these GAGs playing a role in the commitment of stem cells to chondrocyte progenitors and in the differentiation of progenitors to mature chondrocytes? Alternatively, do they have a role only in one of these biological processes? We evaluated the role of HA, CS, and – above all – BC in cell commitment and chondrocyte differentiation of MSCs by supplementing these GAGs in different phases of in vitro cultivation. Our data provided evidence that a combination of HA and CS or of HA and BC supplemented during the terminal in vitro differentiation and not during cell commitment of MSCs improved chondrocytes differentiation without the presence of fibrosis (reduced expression of Type I collagen). This result suggests that a careful evaluation of extracellular cues for chondrocyte differentiation is fundamental to obtaining a proper maturation process.
- Published
- 2020
14. Positive Effects against UV-A Induced Damage and Oxidative Stress on an In Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals
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Chiara Schiraldi, Valentina Vassallo, Stella Donato, Antonietta Stellavato, Mario De Rosa, Stefania Filosa, Alba Di Pardo, Ilaria Scognamiglio, Gilberto Bellia, Anna Virginia Adriana Pirozzi, Sabrina Reale, Stellavato, A, Pirozzi, A, Donato, S, Scognamiglio, I, Reale, S, Di Pardo, A, Filosa, S, Vassallo, V, Bellia, G, De Rosa, M, and Schiraldi, Chiara
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0301 basic medicine ,Antioxidant ,Article Subject ,medicine.medical_treatment ,Cell ,lcsh:Medicine ,Video microscopy ,oxidative damage ,medicine.disease_cause ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,dermal fillers ,skin photoaging ,Hyaluronic acid ,medicine ,chemistry.chemical_classification ,General Immunology and Microbiology ,lcsh:R ,ROS ,General Medicine ,In vitro ,UV ,Amino acid ,HaCaT ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Biochemistry ,030220 oncology & carcinogenesis ,Oxidative stress ,Research Article - Abstract
Ultraviolet (UV) radiations are responsible for skin photoaging inducing alteration of the molecular and cellular pathways resulting in dryness and reduction of skin elasticity. In this study, we investigated, in vitro, the antiaging and antioxidant effects of hyaluronan formulations based hydrogel. Skinkò E, an intradermic formulation composed of hyaluronic acid (HA), minerals, amino acids, and vitamins, was compared with the sole HA of the same size. For this purpose, HaCaT cells were subjected to UV-A radiations and H2O2 exposure and then treated with growth medium (CTR) combined with M-HA or Skinkò E to evaluate their protective ability against stressful conditions. Cells reparation was evaluated using a scratch in vitro model and Time-Lapse Video Microscopy. A significant protective effect for Skinkò E was shown with respect to M-HA. In addition, Skinkò E increased cell reparation. Therefore, NF-kB, SOD-2, and HO-1 were significantly reduced at the transcriptional and protein level. Interestingly, γ-H2AX and protein damage assay confirmed the protection by hyaluronans tested against oxidative stress. G6pdΔ ES cell line, highly susceptible to oxidative stress, was used as a further cellular model to assess the antioxidant effect of Skinkò E. Western blotting analyses showed that the treatment with this new formulation exerts marked antioxidant action in cells exposed to UV-A and H2O2. Thus, the protective and reparative properties of Skinkò E make it an interesting tool to treat skin aging.
- Published
- 2018
15. Chondroitin Sulfate in USA Dietary Supplements in Comparison to Pharma Grade Products: Analytical Fingerprint and Potential Anti-Inflammatory Effect on Human Osteoartritic Chondrocytes and Synoviocytes
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Chiara Schiraldi, Rosario Finamore, Odile Francesca Restaino, Elisabetta Cassese, Antonietta Stellavato, Carlo Ruosi, Valentina Vassallo, Stellavato, A., Restaino, O. F., Vassallo, V., Cassese, E., Finamore, R., Ruosi, C., and Schiraldi, C.
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Inflammation biomarker ,capillary electrophoresis (HPCE) ,Keratan sulfate ,medicine.drug_class ,Pharmaceutical Science ,Pharmacology ,Article ,Anti-inflammatory ,Proinflammatory cytokine ,03 medical and health sciences ,chemistry.chemical_compound ,Pharmacy and materia medica ,0302 clinical medicine ,Glucosamine ,medicine ,Viability assay ,Chondroitin sulfate ,Anion exchange chromatography (HPAE‐PAD) ,030304 developmental biology ,Cartilage oligomeric matrix protein ,0303 health sciences ,biology ,Size exclusion chromatography (SEC‐TDA) ,Human primary cells of pathological joint ,human primary cells of pathological joints ,food supplements (FS) ,pharmaceutical grade CS ,size exclusion chromatography (SEC-TDA) ,In vitro ,inflammation biomarkers ,RS1-441 ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,anion exchange chromatography (HPAE-PAD) - Abstract
The biological activity of chondroitin sulfate (CS) and glucosamine (GlcN) food supplements (FS), sold in USA against osteoarthritis, might depend on the effective CS and GlcN contents and on the CS structural characteristics. In this paper three USA FS were compared to two pharmaceutical products (Ph). Analyses performed by HPAE-PAD, by HPCE and by SEC-TDA revealed that the CS and GlcN titers were up to −68.8% lower than the contents declared on the labels and that CS of mixed animal origin and variable molecular weights was present together with undesired keratan sulfate. Simulated gastric and intestinal digestions were performed in vitro to evaluate the real CS amount that may reach the gut as biopolymer. Chondrocytes and synoviocytes primary cells derived from human pathological joints were used to assess: cell viability, modulation of the NF-κB, quantification of cartilage oligomeric matrix protein (COMP-2), hyaluronate synthase enzyme (HAS-1), pentraxin (PTX-3) and the secreted IL-6 and IL-8 to assess inflammation. Of the three FS tested only one (US FS1) enhanced chondrocytes viability, while all of them supported synoviocytes growth. Although US FS1 proved to be less effective than Ph as it reduced NF-kB, it could not down-regulate COMP-2, HAS-1 was up-regulated but with a lower efficacy. Inflammatory cytokines were markedly reduced by Ph while a slight decrease was only found for US-FS1.
- Published
- 2021
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