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189 results on '"Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])"'

1. HbF-promoting polymorphisms may specifically reduce the residual risk of cerebral vasculopathy in SCA children with alpha-thalassemia

Author

Philippe Connes, Céline Renoux, Abdourahim Chamouine, Yves Bertrand, Françoise Bernaudin, Nathalie Bonello-Palot, Catherine Badens, Philippe Joly, Serge Pissard, Gall, Valérie, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Référence des Syndromes Drépanocytaires Majeurs, Thalassémies et Autres pathologies rares du globule rouge et de l’Erythropoïèse, Assistance Publique - Hôpitaux de Marseille (APHM), Hôpital Henri Mondor, Centre Hospitalier de Mayotte, Centre Hospitalier Intercommunal de Créteil (CHIC), Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe), Hospices Civils de Lyon (HCL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, congenital, hereditary, and neonatal diseases and abnormalities, Physiology, Anemia, Sickle Cell, [SDV.GEN] Life Sciences [q-bio]/Genetics, Alpha-thalassemia, Disease, Quantitative trait locus, Polymorphism, Single Nucleotide, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, alpha-Thalassemia, hemic and lymphatic diseases, Physiology (medical), Genotype, medicine, Humans, Child, Fetal Hemoglobin, [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Hematology, medicine.disease, Sickle cell anemia, Residual risk, Red blood cell, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Female, Cardiology and Cardiovascular Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030215 immunology
Abstract

International audience; Sickle cell anemia (SCA) is a disease characterized by abnormal red blood cell rheology. Because of their effects on HbS polymerization and red blood cell deformability, alpha-thalassemia and the residual HbF level are known genetic modifiers of the disease. The aim of our study was to determine if the number of HbF quantitative trait loci (QTL) would also favor a specific sub-phenotype of SCA as it is the case for alpha-thalassemia. Our results confirmed that alpha-thalassemia protected from cerebral vasculopathy but increased the risk for frequent painful vaso-occlusive crises. We also showed that more HbF-QTL may provide an additional and specific protection against cerebral vasculopathy but only for children with alpha-thalassemia (-α/αα or -α/-α genotypes).

Published
2021

2. Two new reliable immunohistochemical methods for simultaneous identification of capillaries, the three types of fibers and basal lamina in human skeletal muscle

Author

Julien Verney, Bruno Pereira, Mélina Bailly, Amandine Boileau, Bogdan Galusca, David Thivel, Natacha Germain, Daniel Courteix, Christophe Hourdé, Léonard Féasson, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Troubles du Comportement Alimentaire, Addictions et Poids Extêmes (TAPE - TCA), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), TAPE laboratory [Saint-Étienne], and Université Jean Monnet [Saint-Étienne] (UJM)

Subjects
0301 basic medicine, Histology, Capillary action, Muscle Fibers, Skeletal, Antigens, CD34, Basement Membrane, 03 medical and health sciences, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Humans, Capillary supply, Fiber, Muscle fibre, Molecular Biology, Combined staining method, Reproducibility, 030102 biochemistry & molecular biology, Chemistry, Antibodies, Monoclonal, Skeletal muscle, Cell Biology, Immunohistochemistry, Muscle fiber type, Capillaries, Medical Laboratory Technology, 030104 developmental biology, medicine.anatomical_structure, CD31, Basal lamina, Metabolic profile, Biomedical engineering
Abstract

International audience; Capillary network of skeletal muscle has a crucial role in oxygen supply and is strongly associated with the phenotype and metabolic profile of muscle fibers. Abundant literature has explored capillarization of skeletal muscle in different populations and in response to different interventions. Capillary and fiber type identification techniques have considerably evolved over the last decades, but to the best of our knowledge, no validated immunohistochemical method has yet been developed to simultaneously identify capillaries (using CD31), the three different muscle fiber types, and basal lamina. Nine human muscle biopsies of vastus lateralis were stained using 5 different methods to test: the reliability of different CD31 antibodies for capillary identification, the reliability between single-section or serial-section methods, and the intra-experimenter reproducibility in visual detection of capillaries. High reliability for the different antibodies directed against capillaries was observed for capillary contacts (CC) measurements (intra-class correlations (ICC) [ICC95%] of 0.89 [0.72; 0.96] for type I fibers, 0.93 [0.81; 0.97] for type IIA fibers, 0.88 [0.71; 0.96] for type IIX fibers, 0.95 [0.86; 0.98] for all fiber types) as well as a high level of similarity between single and serial sections methods. A strong similarity in capillary analysis between the different methods was obtained for each sample measurements. Analysis of Lin's concordance correlation coefficients and Bland and Altman's graphics showed a strong intra-experimenter reproducibility. This article proposes two time- and tissue-sparing immunohistochemical methods to accurately assess a complete fiber typing (type I, IIA, and IIX) along with muscle capillarization on a single muscle section.

Published
2020

3. Sex Differences in Neuromuscular Fatigue and Changes in Cost of Running after Mountain Trail Races of Various Distances

Author

Audrey Parent, Guillaume Y. Millet, Vincent Martin, Callum G. Brownstein, Thomas Lapole, Benjamin Singh, Giorgio Varesco, Thibault Besson, Loïc Espeit, John Temesi, Diana Rimaud, Frederic Sabater Pastor, Nicolas Royer, Jérémy Rossi, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Department of Biological Sciences, Université du Québec à Montréal, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Faculty of Health & Life Sciences, Northumbria University, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), University of Northumbria at Newcastle [United Kingdom], Besson, Thibault, Parent, Audrey, Brownstein, Callum G, Espeit, Loic, Lapole, Thomas, Martin, Vincent, Royer, Nicolas, Rimaud, Diana, Sabater Pastor, Frederic, Singh, Benjamin, Varesco, Giorgio, Rossi, Jeremy, Temesi, John, and Millet, Guillaume Y

Subjects
Male, medicine.medical_specialty, Competitive Behavior, males, Physical Therapy, Sports Therapy and Rehabilitation, Marathon Running, Plantar flexion, trail running, Oxygen Consumption, Internal medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Humans, Orthopedics and Sports Medicine, Knee, Treadmill, Respiratory exchange ratio, Creatine Kinase, ComputingMilieux_MISCELLANEOUS, Sex Characteristics, Knee extensors, business.industry, Electromyography, Foot, Pulmonary Gas Exchange, C100, females, Evoked Potentials, Motor, C600, Transcranial Magnetic Stimulation, Electric Stimulation, energy cost, Peripheral, C-Reactive Protein, Neuromuscular fatigue, Torque, Muscle Fatigue, Breathing, Cardiology, Running economy, Physical Endurance, fatigability, Female, business, Energy Metabolism
Abstract

Introduction: Women have been shown to experience less neuromuscular fatigue than men in knee extensors (KE) and less peripheral fatigue in plantar flexors (PF) after ultratrail running, but it is unknown if these differences exist for shorter trail running races and whether this may impact running economy. The purpose of this study was to characterize sex differences in fatigability over a range of running distances and to examine possible differences in the postrace alteration of the cost of running (Cr). Methods: Eighteen pairs of men and women were matched by performance after completing different races ranging from 40 to 171 km, divided into SHORT versus LONG races (100 km, respectively). Neuromuscular function and Cr were tested before and after each race. Neuromuscular function was evaluated on both KE and PF with voluntary and evoked contractions using electrical nerve (KE and PF) and transcranial magnetic (KE) stimulation. Oxygen uptake, respiratory exchange ratio, and ventilation were measured on a treadmill and used to calculate Cr. Results: Compared with men, women displayed a smaller decrease in maximal strength in KE (−36% vs −27%, respectively, P < 0.01), independent of race distance. In SHORT only, women displayed less peripheral fatigue in PF compared with men (Δ peak twitch: −10% vs −24%, respectively, P < 0.05). Cr increased similarly in men and women. Conclusions: Women experience less neuromuscular fatigue than men after both “classic” and “extreme” prolonged running exercises but this does not impact the degradation of the energy Cr. Refereed/Peer-reviewed

Published
2021

4. Actualisation des recommandations françaises de traitement du pemphigus

Author

Catherine Prost-Squarcioni, Olivier Dereure, Vivien Hébert, C. Le Roux-Villet, Fabienne Jouen, E. Le Bidre, M-P Konstantinou, Frédéric Caux, Nadège Cordel, L Jelti, Gaëlle Quéreux, Catherine Picard-Dahan, J. Plée, Christophe Bedane, Michel D'Incan, Denis Jullien, M-A Viguier, Sophie Duvert-Lehembre, Bruno Sassolas, Marina Alexandre, I Bourgault Villada, E. Tancrede-Bohin, Pascal Joly, J-D Bouaziz, Saskia Ingen-Housz-Oro, M-S Doutre, Sébastien Debarbieux, M-A Richard, Emmanuel Delaporte, B. Mellottee, P. Bernard, Service de dermatologie [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Energie Atomique (CEA), Institut de Biologie et Technologies de Saclay, Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de dermatologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de dermatologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Fonctionnement et évolution des systèmes écologiques (FESE), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Institut Laue-Langevin (ILL), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand, Laboratoire de Chimie Industrielle, École Nationale d'Ingénieurs de Sfax | National School of Engineers of Sfax (ENIS), CHU Bordeaux [Bordeaux], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Hopital de Bohars - CHRU Brest (CHU - BREST ), Hôpital Robert Debré, CRCM, Université Paris7, Assistance Publique - Hôpitaux de Paris, Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ArcelorMittal Maizières Research SA, ArcelorMittal, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen], École normale supérieure - Paris (ENS Paris), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), ILL, Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
medicine.medical_specialty, business.industry, MEDLINE, [SDV.CAN]Life Sciences [q-bio]/Cancer, Dermatology, medicine.disease, 030207 dermatology & venereal diseases, 03 medical and health sciences, Pemphigus, 0302 clinical medicine, 030220 oncology & carcinogenesis, Severity of illness, medicine, Intensive care medicine, business, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

5. Central fatigue aetiology in prolonged trail running races

Author

Callum G. Brownstein, Thibault Besson, Nicolas Royer, Vincent Martin, Loïc Espeit, Guillaume Y. Millet, Thomas Lapole, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
medicine.medical_specialty, Physiology, Tibial nerve stimulation, 030204 cardiovascular system & hematology, Plantar flexion, Running, 03 medical and health sciences, 0302 clinical medicine, Voluntary contraction, Physical medicine and rehabilitation, Physiology (medical), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Medicine, Mont blanc, Muscle, Skeletal, ComputingMilieux_MISCELLANEOUS, Nutrition and Dietetics, business.industry, Electromyography, General Medicine, Torque, Muscle Fatigue, Etiology, Physical Endurance, H-reflex, business, 030217 neurology & neurosurgery, Gastrocnemius medialis, Muscle Contraction
Abstract

NEW FINDINGS What is the central question of this study? Are spinal and/or supraspinal perturbations implicated in central fatigue induced in the plantar flexor muscles following prolonged trail running races? What is the main finding and its importance? The study confirmed the presence of central fatigue following various trail running distances from 40 to 170 km. The reduction in the V-wave in conjunction with the lack of change in the H-reflex suggests that a major component of this central fatigue may arise from supraspinal mechanisms in the plantar flexor muscles. ABSTRACT Trail running races are known to induce considerable impairments in neuromuscular function of which central mechanisms are a substantial component. However, the loci of this central fatigue (i.e. supraspinal and/or spinal) is not well identified. The aim of this study was to better understand central fatigue aetiology induced in the plantar flexor muscles by various trail running distances from 40 to 170 km. Eighteen runners participated in the study and neuromuscular function of their plantar flexors was tested before (PRE) and after (POST) various races during the Ultra-Trail du Mont Blanc. Neuromuscular function was evaluated with voluntary and evoked contractions using electrical tibial nerve stimulation. H-reflex and V-wave responses were also measured during submaximal and maximal voluntary contraction, respectively. Reductions in maximal voluntary contraction torque (-29%; P

Published
2020

6. 3D Visualization of Body Motion in Speed Climbing

Author

Franck Quaine, Lionel Reveret, Pierre Legreneur, Sylvain Chapelle, Calcul des Variations, Géométrie, Image (CVGI), Laboratoire Jean Kuntzmann (LJK), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Fédération Française de la Montagne et de l'Escalade, GIPSA - Analyse et Modification de l'homme en mouvement : biomécanique, cognition, vocologie (GIPSA-MOVE), GIPSA Pôle Sciences des Données (GIPSA-PSD), Grenoble Images Parole Signal Automatique (GIPSA-lab), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Motion analysis, lcsh:BF1-990, Tracking (particle physics), biomechanics, 050105 experimental psychology, Motion (physics), [SPI]Engineering Sciences [physics], 03 medical and health sciences, 0302 clinical medicine, video analysis, Psychology, 0501 psychology and cognitive sciences, Computer vision, Polygon mesh, General Psychology, Original Research, Plane (geometry), business.industry, motion analysis, 05 social sciences, speed climbing, Visualization, lcsh:Psychology, 3D visualization, center of mass, Climbing, Artificial intelligence, business, 030217 neurology & neurosurgery, Energy (signal processing)
Abstract

International audience; Speed climbing involves an optimization of the velocity of the ascent and the trajectory path during performance. Consequently, any amount of energy spent in the two other directions than vertical, namely the lateral direction and the direction perpendicular to the wall plane, is a potential loss of performance. To assess this principle, we present a study on 3D motion analysis and its 3D visualization for a subject during a speed climbing performance. The fundamentals of geometrical measurement in 3D require to integrate multiple 2D cues, at least two, in order to extract 3D information. First results with two drones following an athlete's ascent show that a 3D velocity profile can be provided from the tracking of a marker on the harness, pointing critical phases in the ascent where the vertical speed is not dominant any more. We further investigate 3D motion of full body using markerless video-based tracking. Our approach is based on a full body 3D avatar model of the climber, represented as a 3D mesh. This model and its deformation are learned in a laboratory studio. The learning needs to be done only once. Result is a manifold embedding of the 3D mesh and its deformations, which can be used afterwards to perform registration onto video of performance of speed climbing. The results of the tracking is an inference of the 3D mesh aligned onto videos of speed climbing performance. From this 3D mesh, we deduce an estimation of the center of mass (COM). We show that this estimation from 3D mesh differs from the usual approximation of the COM as a marker on the harness. In particular, the 3D mesh COM takes into account the whole body movement such as the influence of the limbs which is not detected by a marker on the harness.

Published
2020

7. Comparison of Active and Sedentary Bout Lengths in Normal and Overweight Adults using eMouverecherche

Author

Rousset, Sylvie, Ludivine, Paris, Romain, Guidoux, Damien, Saboul, Martine, Duclos, Yves, Boirie, Sylvie, Rousset, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), IP Leanware, ALMERYS, Orange Business Services, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Service Médecine du Sport et des Explorations Fonctionnelles, CHU Clermont-Ferrand, Service de Nutrition Clinique [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Service Médecine du Sport et Explorations Fonctionnelles [CHU Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand]

Subjects
Accelerometer, Physical activity bout, Sedentary bout, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Overweight adults, human activities, eMouveRecherche application, ComputingMilieux_MISCELLANEOUS, Normal-weight adults
Abstract

International audience; BackgroundPhysical inactivity and long sedentary time are common in obese people. The eMouveRecherche application was developed to provide accurate minute-by-minute classification of physical activity in light, moderate, vigorous intensity and sedentary bouts. The aim was to compare the frequency and length of bouts in Normal-Weight (NW) and Overweight (OW) adults.MethodsFifty-seven adult participants either normal weight or overweight wore a smartphone with the eMouve application for the entire waking period of the day. The continuous 1-5, 5-15, 15-30, 30-60 and higher than 60-minute bouts for each behavior were counted.ResultsThe total number of bouts was higher in NW than in OW (12.4 vs. 9.8 bouts.h-1, p < 0.001). The breakdown of immobile and active bouts according to their length was different in the two groups. The NW had a significantly higher percentage of brief immobile bouts (1-5 min) (65.2% vs. 49.7%), while OW had a significantly higher percentage of 5-15 min (26.8% vs. 19.1%) and 15-30 min sedentary bouts (11.8% vs. 8.0%). The 1-5 min bouts of light-intensity activity were statistically more frequent in OW (93.6% vs. 83.5%), whereas bouts of 5-15 min (15.1% vs. 6.4%) and 15-30 min bouts (1.3% vs. 0%) were more common in NW.ConclusionThe frequency of both immobile and light-intensity activity bouts was lower in OW, whereas the duration of bouts was respectively longer for immobile behavior and shorter for light-intensity activity, resulting in a continuous sedentary pattern with few active breaks. The overweight appears to be a barrier to the spontaneous practice of light-intensity physical activity.

Published
2019

8. Réduction de modèle numérique pour la prévision de la pression d'interface appliquée par les bandages de compression sur la jambe inférieure

Author

Jérôme Molimard, Reynald Convert, Pierre Badel, Fanette Chassagne, Pascal Giraux, INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Thuasne, Université Jean Monnet - Faculté de Médecine, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Molimard, Jérôme, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Ingénierie et Santé (CIS-ENSMSE), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University Jean Monnet

Subjects
Adult, Male, Patient-Specific Modeling, Materials science, Compression Bandage, Friction, Finite Element Analysis, 0206 medical engineering, Biomedical Engineering, 02 engineering and technology, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, [SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Compression Bandages, model reduction, Pressure, Humans, Vascular Diseases, Lymphatic Diseases, Leg, Computer simulation, Tension (physics), [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Mechanics, Middle Aged, 020601 biomedical engineering, Finite element method, Pressure measurement, interface pressure, Female, Reduction (mathematics), Parametrization, Finite element simulation, Bandage
Abstract

International audience; Objective: To develop a new method for the prediction of interface pressure applied by medical compression bandages. Methods: A finite element simulation of bandage application was designed, based on patient-specific leg geometries. For personalized interface pressure prediction, a model reduction approach was proposed, which included the parametrization of the leg geometry. Pressure values computed with this reduced model were then confronted to experimental pressure values. Results: The most influencing parameters were found to be the bandage tension, the skin-to-bandage friction coefficient and the leg morphology. Thanks to the model reduction approach, it was possible to compute interface pressure as a linear combination of these parameters. The pressures computed with this reduced model were in agreement with experimental pressure values measured on 66 patients' legs. Conclusion: This methodology helps to predict patient-specific interface pressure applied by compression bandages within a few minutes whereas it would take a few days for the numerical simulation. The results of this method show less bias than Laplace's Law, which is for now the only other method for interface pressure computation.

Published
2018

9. Evolution of blood rheology and its relationship to pulmonary hemodynamic during the first days of exposure to moderate altitude

Author

Jorge Lopez Ayerbe, Patrick Mucci, Philippe Connes, Fabienne Durand, Antoine Raberin, Elie Nader, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université de Lille-Université du Littoral Côte d'Opale (ULCO), Laboratoire Européen Performance Santé Altitude (LEPSA), Université de Perpignan Via Domitia (UPVD), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), and Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369 (URePSSS)

Subjects
Adult, Male, medicine.medical_specialty, Pulmonary Circulation, Physiology, Blood viscosity, Hemodynamics, 030204 cardiovascular system & hematology, Hematocrit, Acclimatization, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, [SCCO]Cognitive science, Young Adult, 0302 clinical medicine, Physiology (medical), Internal medicine, Hypoxic pulmonary vasoconstriction, medicine, Humans, ComputingMilieux_MISCELLANEOUS, medicine.diagnostic_test, business.industry, Altitude, Hematology, Hemoconcentration, Healthy Volunteers, Red blood cell, medicine.anatomical_structure, Vascular resistance, Cardiology, Cardiology and Cardiovascular Medicine, business, Rheology
Abstract

Blood rheology and hemodynamic parameters have never been explored together during acclimatization to altitude. This study aimed to investigate changes in blood rheology parameters and pulmonary hemodynamics during the first days of real moderate altitude exposure.Seventeen athletes were tested at sea-level, 20 hours after their arrival at 2,400 meters of altitude (H1) and five days later (H2). Blood was sampled to analyze red blood cell (RBC) aggregation, blood viscosity and hematocrit. Pulmonary arterial pressure (PAP), pulmonary capillary pressure (Pcap) and pulmonary vascular resistance (PVR) were assessed by echocardiography.We observed a rise in hematocrit, blood viscosity, RBC aggregation, PAP, Pcap and PVR between sea-level and H1. In H2, RBC aggregation, hematocrit, PAP, Pcap and PVR remained different compared to sea-level and no difference was observed between H1 and H2. Blood viscosity decreased in H2 and returned to sea-level values.Our results suggest that hemoconcentration occurring within the first hours of altitude exposure increased blood viscosity, which contributed to the changes in pulmonary hemodynamic. When blood viscosity decreased in H2, no change occurred in pulmonary hemodynamic parameters suggesting that hypoxic pulmonary vasoconstriction was still present. The elevated RBC aggregation observed after in H2 could participate in the increase of Pcap.

Published
2019

10. The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β0-thalassaemia homozygotes

Author

Sule Unal, Bernard G. Forget, Nejat Akar, Martin H. Steinberg, A. Nazli Basak, Fatma Gumruk, Catherine Badens, Patrick G. Gallagher, Leonor Osorio, Serge Pissard, Nasir A. S. Al-Allawi, Roger Théberge, Andrew D. Campbell, John J. Farrell, Zhihua Jiang, Suchada Riolueang, Philippe Joly, Hong-Yuan Luo, Shengwen Huang, Katherine A. Benson, Vip Viprakasit, Lance Davis, David H.K. Chui, Departments of Medicine, Pathology and Laboratory Medicine, Boston University School of Medicine (BUSM), Boston University [Boston] (BU)-Boston University [Boston] (BU), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Genetique, UPEC (Universite' Paris Est Creteil), Laboratoire de Genetique, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), University of Michigan [Ann Arbor], University of Michigan System, Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)

Subjects
Male, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Genes, myb, [SDV]Life Sciences [q-bio], Dizygotic twin, Quantitative Trait Loci, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, HBG2, Frameshift mutation, Loss of heterozygosity, Young Adult, 03 medical and health sciences, Polymorphism (computer science), hemic and lymphatic diseases, Fetal hemoglobin, Diseases in Twins, Twins, Dizygotic, medicine, Humans, Frameshift Mutation, Fetal Hemoglobin, ComputingMilieux_MISCELLANEOUS, Genetics, Homozygote, beta-Thalassemia, Nuclear Proteins, Beta thalassemia, Hematology, Middle Aged, medicine.disease, Molecular biology, Repressor Proteins, 030104 developmental biology, Female, Carrier Proteins
Abstract

Two 21-year old dizygotic twin men of Iraqi descent were homozygous for HBB codon 8, deletion of two nucleotides (-AA) frame-shift β(0) -thalassaemia mutation (FSC8; HBB:c25_26delAA). Both were clinically well, had splenomegaly, and were never transfused. They had mild microcytic anaemia (Hb 120-130 g/l) and 98% of their haemoglobin was fetal haemoglobin (HbF). Both were carriers of Hph α-thalassaemia mutation. On the three major HbF quantitative trait loci (QTL), the twins were homozygous for G>A HBG2 Xmn1 site at single nucleotide polymorphism (SNP) rs7482144, homozygous for 3-bp deletion HBS1L-MYB intergenic polymorphism (HMIP) at rs66650371, and heterozygous for the A>C BCL11A intron 2 polymorphism at rs766432. These findings were compared with those found in 22 other FSC8 homozygote patients: four presented with thalassaemia intermedia phenotype, and 18 were transfusion dependent. The inheritance of homozygosity for HMIP 3-bp deletion at rs66650371 and heterozygosity for Hph α-thalassaemia mutation was found in the twins and not found in any of the other 22 patients. Further studies are needed to uncover likely additional genetic variants that could contribute to the exceptionally high HbF levels and mild phenotype in these twins.

Published
2016

11. Feasibility of an exercise and nutritional intervention for weight management during adjuvant treatment for localized breast cancer: the PASAPAS randomized controlled trial

Author

Valérie Bourne-Branchu, Thomas Bachelot, Magali Morelle, Patrick Bachmann, Anne-Sophie Kempf-Lépine, Cédric Baudinet, Séverine Guillemaut, Sophie E. Berthouze, David Pérol, Eric Reynes, Elodie Grinand, Marina Touillaud, Julien Carretier, Paul Rebattu, Lionel Perrier, Aude-Marie Foucaut, Pierre-Etienne Heudel, Renaud Meyrand, Olivier Tredan, Sylvie Chabaud, Séverine Metzger, Béatrice Fervers, Laboratoire Educations et Pratiques de Santé (LEPS), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Léon Bérard [Lyon], Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire sur les Vulnérabilités et l'Innovation dans le Sport (EA 7428) (L-VIS), Université de Lyon-Université de Lyon, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), 2010-228/VO-HO, Institut National Du Cancer, PME 2010-2011, Ligue Contre le Cancer, 2010-15024, Fondation de France, CIFRE/ANRT 426/2010, Association Nationale de la Recherche et de la Technologie, CLARA Programme structurant 2010, Cancéropôle Lyon Auvergne Rhône-Alpes, Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, medicine.medical_specialty, Adolescent, Breast Neoplasms, Overweight, Weight Gain, law.invention, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Breast cancer, Randomized controlled trial, law, Weight management, medicine, Aerobic exercise, Humans, 030212 general & internal medicine, Obesity, Exercise, Nutrition, Aged, business.industry, Physical activity, Anthropometry, Middle Aged, medicine.disease, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 3. Good health, Exercise Therapy, Clinical trial, Oncology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Physical therapy, Body Composition, Feasibility Studies, Patient Compliance, Female, France, medicine.symptom, Neoplasm Recurrence, Local, business, Dieting
Abstract

International audience; PURPOSE: Lack of physical activity (PA), weight gain, and overweight have been associated with increased risk of recurrence and mortality after breast cancer diagnosis. We evaluated the feasibility of implementing an individualized exercise program and nutritional counseling during adjuvant treatment of localized invasive breast cancer. METHODS: Sixty-one patients eligible for adjuvant chemotherapy were randomized 2:1 to receive a 6-month program of weekly aerobic exercises associated with nutritional counseling (n = 41) or usual care with nutritional counseling (n = 20, one withdrawal). The primary endpoints were the proportion of patients compliant with two weekly supervised sessions and their overall adherence (i.e., proportion of supervised and unsupervised sessions completed versus planned sessions). RESULTS: Ten percent of patients in the intervention group were compliant with the two weekly supervised sessions for 6 months, but the overall median adherence rate was 85% of supervised and non-supervised sessions completed. Non-adherence was mainly due to intrinsic reasons (medical, organizational, psychological barriers). Adherence was positively associated with education and baseline PA level and inversely associated with baseline weight and tumor grade. No statistically significant benefits were observed in the intervention group, even if overall PA level and body composition improved and anthropometrics were maintained over time (p \textless 0.05). CONCLUSIONS: Overall, there was good adherence with the 6-month exercise program during adjuvant treatment for breast cancer, despite poor compliance to twice-weekly supervised sessions. This study highlights the need for flexible exercise modalities and innovative experimental design to reach patients who would most adhere and benefit from intervention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01331772. Registered 8 April 2011, https://clinicaltrials.gov/ct2/show/NCT01331772?term=pasapas&rank=1.

Published
2018

12. Pharmacological inhibition of myostatin improves skeletal muscle mass and function in a mouse model of stroke

Author

Josiane Castells, Marine Maud Desgeorges, Damien Freyssenet, Christopher Haqq, Omar Touzani, David Frédéric Arnould, Myriam Bernaudin, Anne-Cécile Durieux, Didier Divoux, Xavier Devillard, Jérôme Toutain, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Hypoxie, physiopathologies cérébrovasculaire et tumorale (CERVOxy), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Atara Biotherapeutics, Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Weakness, [SDV]Life Sciences [q-bio], Science, Ischemia, Myostatin, Muscle Development, Article, Mice, 03 medical and health sciences, Subcutaneous injection, 0302 clinical medicine, Internal medicine, Occlusion, medicine, Animals, cardiovascular diseases, Stroke, Multidisciplinary, biology, business.industry, Skeletal muscle, medicine.disease, Peptide Fragments, Disease Models, Animal, Muscular Atrophy, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, biology.protein, Medicine, medicine.symptom, Myofibril, business, 030217 neurology & neurosurgery
Abstract

In stroke patients, loss of skeletal muscle mass leads to prolonged weakness and less efficient rehabilitation. We previously showed that expression of myostatin, a master negative regulator of skeletal muscle mass, was strongly increased in skeletal muscle in a mouse model of stroke. We therefore tested the hypothesis that myostatin inhibition would improve recovery of skeletal muscle mass and function after cerebral ischemia. Cerebral ischemia (45 minutes) was induced by intraluminal right middle cerebral artery occlusion (MCAO). Swiss male mice were randomly assigned to Sham-operated mice (n = 10), MCAO mice receiving the vehicle (n = 15) and MCAO mice receiving an anti-myostatin PINTA745 (n = 12; subcutaneous injection of 7.5 mg.kg−1 PINTA745 immediately after surgery, 3, 7 and 10 days after MCAO). PINTA745 reduced body weight loss and improved body weight recovery after cerebral ischemia, as well as muscle strength and motor function. PINTA745 also increased muscle weight recovery 15 days after cerebral ischemia. Mechanistically, the better recovery of skeletal muscle mass in PINTA745-MCAO mice involved an increased expression of genes encoding myofibrillar proteins. Therefore, an anti-myostatin strategy can improve skeletal muscle recovery after cerebral ischemia and may thus represent an interesting strategy to combat skeletal muscle loss and weakness in stroke patients.

Published
2017

13. HLA-DR expression on monocytes and outcome of anti-CD19 CAR T-cell therapy for large B-cell lymphoma

Author

Estelle Bourbon, Pierre Sesques, Morgane Gossez, Jérémie Tordo, Emmanuelle Ferrant, Violaine Safar, Florent Wallet, Guillaume Aussedat, Alizée Maarek, Fadhela Bouafia, Lionel Karlin, Dana Ghergus, Camille Golfier, Hélène Lequeu, Anne Lazareth, Vérane Schwiertz, Sébastien Viel, Maryam Idlhaj, Hervé Ghesquières, Guillaume Monneret, Emmanuel Bachy, Fabienne Venet, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
[SDV]Life Sciences [q-bio], Hematology
Abstract

Despite their unprecedented success in relapsed/refractory (R/R) large B-cell lymphoma (LBCL), anti-CD19 CAR T cells are associated with significant toxicity, and more than half of patients relapse. As monocytes emerged as key players in CAR therapy, we sought to evaluate the evolution of HLA-DR expression on monocytes (mHLA-DR) before and after commercial anti-CD19 CAR T-cell infusion in a large cohort (n = 103) of patients with R/R LBCL and its association with adverse events and treatment response. Cy-Flu-based lymphodepletion (LD) upregulated mHLA-DR in 79% of the cases, whereas in 2l% of cases (15 patients), the mHLA-DR level decreased after LD, and this decrease was associated with poorer outcome. Low mHLA-DR at day minus 7 (D−7) (

Published
2023

14. Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model

Author

Constance P. Michel, David Bendahan, Benoit Giannesini, Christophe Vilmen, Yann Le Fur, Laurent A. Messonnier, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Physiology, Physiology (medical), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
Abstract

International audience; Hydroxyurea (HU) is commonly used as a treatment for patients with sickle cell disease (SCD) to enhance fetal hemoglobin production. This increased production is expected to reduce anemia (which depresses oxygen transport) and abnormal Hb content alleviating clinical symptoms such as vaso-occlusive crisis and acute chest syndrome. The effects of HU on skeletal muscle bioenergetics in vivo are still unknown. Due to the beneficial effects of HU upon oxygen delivery, improved skeletal muscle energetics and function in response to a HU treatment have been hypothesized. Muscle energetics and function were analyzed during a standardized rest-exercise-recovery protocol, using 31P-magnetic resonance spectroscopy in Townes SCD mice. Measurements were performed in three groups of mice: one group of 2-mo-old mice (SCD2m, n = 8), another one of 4-mo-old mice (SCD4m, n = 8), and a last group of 4-mo-old mice that have been treated from 2 mo of age with HU at 50 mg/kg/day (SCD4m-HU, n = 8). As compared with SCD2m mice, SCD4m mice were heavier and displayed a lower acidosis. As lower specific forces were developed by SCD4m compared with SCD2m, greater force-normalized phosphocreatine consumption and oxidative and nonoxidative costs of contraction were also reported. HU-treated mice (SCD4m-HU) displayed a significantly higher specific force production as compared with untreated mice (SCD4m), whereas muscle energetics was unchanged. Overall, our results support a beneficial effect of HU on muscle function.

Published
2023

15. Influence of storage and buffer composition on the mechanical behavior of flowing red blood cells

Author

Adlan Merlo, Sylvain Losserand, François Yaya, Philippe Connes, Magalie Faivre, Sylvie Lorthois, Christophe Minetti, Elie Nader, Thomas Podgorski, Céline Renoux, Gwennou Coupier, Emilie Franceschini, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Institut de mécanique des fluides de Toulouse (IMFT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut des Nanotechnologies de Lyon (INL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Aero-Thermo-Mechanics Department, Université libre de Bruxelles (ULB), Laboratoire Rhéologie et Procédés (LRP), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Service de Biochimie et Biologie Moléculaire Grand Est [HCL, Lyon] (Centre de Biologie et de Pathologie), Hospices Civils de Lyon (HCL), Laboratoire de Mécanique et d'Acoustique [Marseille] (LMA ), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), GDR Mécabio, CNRS, and European Project: 615102,EC:FP7:ERC,ERC-2013-CoG,BRAINMICROFLOW(2014)

Subjects
Biophysics, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Abstract

International audience; On-chip study of blood flow has emerged as a powerful tool to assess the contribution of each component of blood to its overall function. Blood has indeed many functions, from gas and nutrient transport to immune response and thermal regulation. Red blood cells play a central role therein, in particular through their specific mechanical properties, that directly influence pressure regulation, oxygen perfusion, or platelet and white cells segregation towards endothelial walls. As the bloom of in-vitro studies has led to the apparition of various storage and sample preparation protocols, we address the question of the robustness of the results involving cell mechanical behavior against this diversity. The effects of three conservation media (EDTA, citrate and glucose-albumin-sodium-phosphate) and storage time on the red blood cell mechanical behavior are assessed under different flow conditions: cell deformability by ektacytometry, shape recovery of cells flowing out of a microfluidic constriction, and cell flipping dynamics under shear flow. The impact of buffer solutions (phosphate-buffered saline and density-matched suspension using iodixanol/Optiprep) are also studied by investigating individual cell flipping dynamics, relative viscosity of cell suspensions and cell structuration under Poiseuille flow. Our results reveal that storing blood samples up to seven days after withdrawal and suspending them in adequate density-matched buffer solutions has in most experiments a moderate effect on the overall mechanical response, with a possible rapid evolution in the first three days after sample collection. SIGNIFICANCE Blood is in intimate contact with all organs in the body, supplying oxygen, nutrients and drugs while removing waste. It carries cells involved in immune response, wound repair and tumor dissemination. Blood is easily collected, revealing the presence of disease through biomarker analysis. It is storable and transfusable. Thus, blood is the subject of many in-vitro studies for research and medical purposes. Guidelines associated to sample preparation or storage conditions have been established, but these may affect its mechanical behavior. In this collaborative study, we provide new guidelines to minimize the impact of specific experimental requirements (e.g. density matching, blood freshness) by focusing on the single or collective motion of red blood cells in a large range of flow conditions.

Published
2023

16. 2022 French Report Card on Physical Activity and Sedentary Behaviors in Children and Youth: From Continuous Alarming Conclusions to Encouraging Initiatives

Author

Alicia Fillon, Jeremy Vanhelst, Pauline Genin, Benjamin Larras, Michéle Tardieu, Marion Porcherie, Maxime Luiggi, Salomé Aubert, Charlotte Verdot, Olivier Rey, Lena Lhuisset, Julien E. Bois, Guillaume Y. Millet, Martine Duclos, David Thivel, Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Observatoire national de l’activité physique et de la sédentarité (ONAPS), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherches sur l'Action Politique en Europe (ARENES), Université de Rennes (UR)-Institut d'Études Politiques [IEP] - Rennes-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Centre National de la Recherche Scientifique (CNRS), École des Hautes Études en Santé Publique [EHESP] (EHESP), Apprentissage, Didactique, Evaluation, Formation (ADEF), Aix Marseille Université (AMU), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Pau et des Pays de l'Adour (UPPA), Environnement, Santé/Stic (E2S), Université de Bourgogne (UB), Mouvement, Équilibre, Performance, Santé (MEPS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
[SDV]Life Sciences [q-bio], active transportation, Orthopedics and Sports Medicine, adolescents, physical activity promotion
Abstract

Background: Scientific evidence and public health reports keep highlighting the continuous and alarming worldwide progression of physical inactivity and sedentary behaviors in children and adolescents. The present paper summarizes findings from the 2022 French Report Card (RC) on physical activity for children and youth and compares them to the 2016, 2018, and 2020 RCs. Methods: The 2022 edition of the French RC follows the standardized methodology established by the Active Healthy Kids Global Matrix. Ten physical activity indicators have been evaluated and graded based on the best available evidence coming from national surveys, peer-reviewed literature, government and nongovernment reports, and online information. The evaluation was also performed in children and adolescents with disabilities. Indicators were graded from A (high level of evidence) to F (very low level of evidence) or INC for incomplete. Results: The evaluated indicators received the following grades: overall physical activity: D−; organized sport participation and physical activity: C; active play: F; active transportation: C; sedentary behaviors: D−; family and peers: D; physical fitness: C; school: C−; community and the built environment: F; government: B. Conclusions: While this 2022 French RC shows progression for 7 out of the 10 indicators considered, it also underlines the continuous need for actions at the local, regional, and national levels to develop better surveillance systems and favor a long-term improvement of youth movement behaviors.

Published
2023

17. Electrically-induced muscle fatigue affects feedforward mechanisms of control

Author

N. Forestier, F. Monjo, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, medicine.medical_specialty, Movement, medicine.medical_treatment, Posture, Safety margin, Electromyography, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Isometric Contraction, Physiology (medical), medicine, Humans, Lead (electronics), ComputingMilieux_MISCELLANEOUS, Rehabilitation, medicine.diagnostic_test, Muscle fatigue, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Feed forward, Healthy subjects, Motor control, 030229 sport sciences, Electric Stimulation, Sensory Systems, Neurology, [ SCCO.NEUR ] Cognitive science/Neuroscience, Muscle Fatigue, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objective To investigate the effects of focal muscle fatigue induced by electromyostimulation (EMS) on Anticipatory Postural Adjustments (APAs) during arm flexions performed at maximal velocity. Methods Fifteen healthy subjects performed self-paced arm flexions at maximal velocity before and after the completion of fatiguing electromyostimulation programs involving the medial and anterior deltoids and aiming to degrade movement peak acceleration. APA timing and magnitude were measured using surface electromyography. Results Following muscle fatigue, despite a lower mechanical disturbance evidenced by significant decreased peak accelerations (−12%, p p >.11 for all analyses). Conclusion The fatigue signals evoked by externally-generated contractions seem to be gated by the Central Nervous System and result in postural strategy changes which aim to increase the postural safety margin. Significance EMS is widely used in rehabilitation and training programs for its neuromuscular function-related benefits. However and from a motor control viewpoint, the present results show that the use of EMS can lead to acute inaccuracies in predictive motor control. We propose that clinicians should investigate the chronic and global effects of EMS on motor control.

Published
2015

18. Transcranial magnetic stimulation probes the excitability of the primary motor cortex: A framework to account for the facilitating effects of acute whole-body exercise on motor processes

Author

Karen Davranche, Thierry Hasbroucq, John Temesi, Samuel Verges, Laboratoire de psychologie cognitive (LPC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire HP2, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Hypoxie et physiopathologies cardiovasculaire et respiratoire, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Elementary cognitive task, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Intracortical inhibition, lcsh:GV557-1198.995, [SCCO]Cognitive science, Exercise-cognitive function interaction, medicine, Orthopedics and Sports Medicine, Effects of sleep deprivation on cognitive performance, lcsh:Sports medicine, ComputingMilieux_MISCELLANEOUS, lcsh:Sports, Mechanism (biology), [SCCO.NEUR]Cognitive science/Neuroscience, C600, Peripheral, C800, Corticospinal excitability, Transcranial magnetic stimulation, medicine.anatomical_structure, Motor processes, Primary motor cortex, lcsh:RC1200-1245, Psychology, Neuroscience, Motor cortex
Abstract

The effects of exercise on decision-making performance have been studied using a wide variety of cognitive tasks and exercise interventions. Although the current literature supports a beneficial influence of acute exercise on cognitive performance, the mechanisms underlying this phenomenon have not yet been elucidated. We review studies that used single-pulse transcranial magnetic stimulation (TMS) to probe the excitability of motor structures during whole-body exercise and present a framework to account for the facilitating effects of acute exercise on motor processes. Recent results suggest that, even in the absence of fatigue, the increase in corticospinal excitability classically reported during submaximal and exhausting exercises may be accompanied by a reduction in intracortical inhibition. We propose that reduced intracortical inhibition elicits an adaptive central mechanism that counteracts the progressive reduction in muscle responsiveness caused by peripheral fatigue. Such a reduction would render the motor cortex more sensitive to upstream influences, thus causing increased corticospinal excitability. Furthermore, reduction of intracortical inhibition may account for the more efficient descending drive and for the improvement of reaction time performance during exercise. The adaptive modulation in intracortical inhibition could be implemented through a general increase in reticular activation that would further account for enhanced sensory sensitivity.

Published
2015
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19. Endurance training reduces exercise-induced acidosis and improves muscle function in a mouse model of sickle cell disease

Author

David Bendahan, Vincent Pialoux, Laurent Messonnier, Christophe Vilmen, Monique Bernard, Philippe Noirez, Benjamin Chatel, Quentin Barge, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Exercise Physiology, University of Savoie, Chambery, and University Jean Monnet of Saint-Etienne, Saint-Etienne, Laboratory of Exercise Physiology, Institut national du sport, de l'expertise et de la performance (INSEP), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire de Physiologie de l'Exercice (LPE), Université Jean Monnet - Saint-Étienne (UJM), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire de Physiologie-Biologie du Sport, and Université d'Auvergne - Clermont-Ferrand I (UdA)

Subjects
0301 basic medicine, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Cell, Physical activity, Mice, Transgenic, Disease, Anemia, Sickle Cell, medicine.disease_cause, Biochemistry, 03 medical and health sciences, Hemoglobins, Mice, Endocrinology, Physical medicine and rehabilitation, Endurance training, Internal medicine, Physical Conditioning, Animal, Genetics, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Muscle, Skeletal, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Acidosis, business.industry, Disease Models, Animal, Endurance Training, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Treatment Outcome, Ph regulation, Muscle Fatigue, medicine.symptom, business, Oxidative stress, Function (biology)
Abstract

Sickle cell disease (SCD) mice (Townes model of SCD) presented exacerbated exercise-induced acidosis and fatigability as compared to control animals. We hypothesize that endurance training could represent a valuable approach to reverse these muscle defects. Endurance-trained HbAA (HbAA-END, n=10), HbAS (HbAS-END, n=11) and HbSS (HbSS-END, n=8) mice were compared to their sedentary counterparts (10 HbAA-SED, 10 HbAS-SED and 9 HbSS-SED mice) during two rest - exercise - recovery protocols during which muscle energetics and function were measured. In vitro analyses of some proteins involved in muscle energetics, pH regulation and oxidative stress were also performed. Exercise-induced acidosis was lower in HbSS-END mice as compared to their sedentary counterparts during both moderate (p0.001) and intense (p0.1) protocols. The total force production measured during both protocols was higher in trained mice compared to sedentary animals. In vitro analyses revealed that enolase/citrate synthase ratio was reduced in HbSS-END (p0.001) and HbAS-END (p0.01) mice compared to their sedentary counterparts. In addition, malondialdehyde concentration was reduced in trained mice (p0.05). In conclusion, endurance training would reverse the more pronounced exercise-induced acidosis, reduce oxidative stress and ameliorate some of the muscle function parameters in SCD mice.

Published
2017

20. Does Central Fatigue Explain Reduced Cycling after Complete Sleep Deprivation?

Author

Karen Davranche, Guillaume Y. Millet, John Temesi, Patrick Levy, Samuel Verges, Régis Bonnefoy, Pierrick J. Arnal, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Lyon, Laboratoire de psychologie cognitive (LPC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hypoxie Physiopathologie (HP2), Université Joseph Fourier - Grenoble 1 (UJF), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Hypoxie et physiopathologies cardiovasculaire et respiratoire, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Physical Therapy, Sports Therapy and Rehabilitation, Neurological disorder, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Endurance training, Internal medicine, Insomnia, medicine, Humans, Orthopedics and Sports Medicine, Effects of sleep deprivation on cognitive performance, Fatigue, Sleep disorder, Cross-Over Studies, business.industry, 030229 sport sciences, medicine.disease, Crossover study, Bicycling, Sleep deprivation, [SCCO.PSYC]Cognitive science/Psychology, Physical Endurance, Physical therapy, Cardiology, Sleep Deprivation, medicine.symptom, business, Psychomotor Performance, 030217 neurology & neurosurgery
Abstract

International audience; Purpose: Sleep deprivation (SD) is characterized by reduced cognitive capabilities and endurance exercise performance and increased perceived exertion (RPE) during exercise. The combined effects of SD and exercise-induced changes in neuromuscular function and cognition are unknown. This study aimed to determine whether central fatigue is greater with SD, and if so, whether this corresponds to diminished cognitive and physical responses. Methods: Twelve active males performed two 2-d conditions (SD and control (CO)). On day 1, subjects performed baseline cognitive and neuromuscular testing. After one night of SD or normal sleep, subjects repeated day 1 testing and then performed 40-min submaximal cycling and a cycling test to task failure. Neuromuscular and cognitive functions were evaluated during the cycling protocol and at task failure. Results: After SD, exercise time to task failure was shorter (1137 +/- 253 vs 1236 +/- 282 s, P = 0.013) and RPE during 40 min submaximal cycling was greater (P = 0.009) than that in CO. Maximal peripheral voluntary activation decreased by 7% (P = 0.003) and cortical voluntary activation tended to decrease by 5% (P = 0.059) with exercise. No other differences in neuromuscular function or cognitive control were observed between conditions. After SD, mean reaction time was 8% longer (P = 0.011) and cognitive response omission rate before cycling was higher (P < 0.05) than that in CO. Acute submaximal exercise counteracted cognitive performance deterioration in SD. Conclusions: One night of complete SD resulted in decreased time to task failure and cognitive performance and higher RPE compared with the control condition. The lack of difference in neuromuscular function between CO and SD indicates that decreased SD exercise performance was probably not caused by increased muscular or central fatigue.

Published
2013

21. Depressed Systolic Function after a Prolonged and Strenuous Exercise

Author

A. Ménétrier, Damien Vitiello, Iris Schuster, Sté Phane Nottin, Philippe Obert, Thomas Rupp, Nicolas Tordi, Cyril Reboul, Johan Cassirame, Physiopathologie des adaptations cardiovasculaires à l'Exercice, Université d'Avignon et des Pays de Vaucluse ( UAPV ), Laboratoire Culture, sport, santé, société - UFC ( C3S ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Université de Franche-Comté ( UFC ), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( PCVP / CARDIO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires ( EA 2992 ), Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire ( LaPEC ), Avignon Université (AU), Laboratoire Culture, sport, santé, société - UFC (EA 4660) (C3S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), EA4278 Laboratoire de Pharm-Ecologie Cardiovasculaire (LaPEC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Adult, Male, Tachycardia, medicine.medical_specialty, Rotational rate, Rest, [SDV]Life Sciences [q-bio], Strenuous exercise, Physical Exertion, Physical Therapy, Sports Therapy and Rehabilitation, Speckle tracking echocardiography, Systolic function, 030204 cardiovascular system & hematology, Ventricular Dysfunction, Left, Young Adult, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Heart Rate, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Internal medicine, Systolic strain, medicine, Humans, Orthopedics and Sports Medicine, Diastolic function, ComputingMilieux_MISCELLANEOUS, business.industry, Incremental test, Bicycling, Echocardiography, Cardiology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

AB Introduction: Prolonged and strenuous exercise (PSE) induces transient left ventricular (LV) dysfunction. Although a consensus exists regarding the decrease in diastolic function, the existence of a decrease in systolic function by a PSE remains controversial, probably due to the transient tachycardia and changes in loading conditions observed upon the completion of exercise. Therefore, the objective was to evaluate LV systolic function before and after a PSE using two-dimensional speckle tracking echocardiography not only at rest but also during incremental tests to adjust heart rates (HR). Methods and Results: Sixteen healthy young men (23 +/- 3 yr old) performed a 3-h period of intensity-controlled upright cycling. LV strain (S), systolic strain rate (SR), rotation, and systolic rotational rate were evaluated by two-dimensional speckle tracking echocardiography before and after a 3-h period of PSE at rest and during incremental tests. Posttest evaluation was performed once the HR had returned to the pretest value. Under resting conditions, parameters of systolic function were either unchanged or increased after the PSE. However, during the incremental test, all LV systolic SR and apical rotational rates were decreased after PSE (radial SR at workload 3 (W3): 2.21 +/- 0.12.s-1 vs 1.87 +/- 0.10.s-1, P < 0.01 and apical rotational rate at W3: 128 +/- 28 deg.s-1 vs 105 +/- 26 deg.s-1, P < 0.05). Regression analyses between LV systolic SR and HR showed lower y-intercepts without differences in slopes, suggesting a decrease of both global and regional systolic functions irrespective of HR after the PSE. Conclusion: Our findings based on LV S and SR data during incremental tests demonstrate that the 3-h period of PSE induces LV systolic dysfunction

Published
2013

22. Cardiorespiratory Fitness and Neuromuscular Function of Mechanically Ventilated ICU COVID-19 Patients*

Author

Guillaume Y. Millet, Djahid Kennouche, Clément Foschia, Callum G. Brownstein, Julien Gondin, Thomas Lapole, Diana Rimaud, Nicolas Royer, Guillaume Thiery, Vincent Gauthier, Lydia Oujamaa, Marine Sorg, Samuel Vergès, Stéphane Doutreleau, Mathieu Marillier, Mélanie Prudent, Laurent Bitker, Léonard Féasson, Laurent Gergelé, Emeric Stauffer, Céline Guichon, Jérôme Morel, SALAS, Danielle, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), CHU Saint-Etienne, Institut NeuroMyoGène (INMG), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Research on Healthcare Performance (RESHAPE - Inserm U1290 - UCBL1), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinique Mutualiste Chirurgicale [Saint-Étienne], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), Hospices Civils de Lyon (HCL), Hôpital de la Croix-Rousse [CHU - HCL], Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hôpital privé de la Loire - Ramsay Santé (HPL-RS)

Subjects
[SDV] Life Sciences [q-bio], Oxygen, Intensive Care Units, Cardiorespiratory Fitness, [SDV]Life Sciences [q-bio], Quality of Life, Aftercare, COVID-19, Humans, Prospective Studies, Critical Care and Intensive Care Medicine, Respiration, Artificial, Patient Discharge
Abstract

International audience; Objectives: The aim of the present study was to investigate the level of cardiorespiratory fitness and neuromuscular function of ICU survivors after COVID-19 and to examine whether these outcomes are related to ICU stay/mechanical ventilation duration.Design: Prospective nonrandomized study.Setting: Patients hospitalized in ICU for COVID-19 infection.Patients: Sixty patients hospitalized in ICU (mean duration: 31.9 ± 18.2 d) were recruited 4-8 weeks post discharge from ICU.Interventions: None.Measurements and main results: Patients visited the laboratory on two separate occasions. The first visit was dedicated to quality of life questionnaire, cardiopulmonary exercise testing, whereas measurements of the knee extensors neuromuscular function were performed in the second visit. Maximal oxygen uptake (V o2 max) was 18.3 ± 4.5 mL·min -1 ·kg -1 , representing 49% ± 12% of predicted value, and was significantly correlated with ICU stay/mechanical ventilation (MV) duration ( R = -0.337 to -0.446; p < 0.01 to 0.001), as were maximal voluntary contraction and electrically evoked peak twitch. V o2 max (either predicted or in mL· min -1 ·kg -1 ) was also significantly correlated with key indices of pulmonary function such as predicted forced vital capacity or predicted forced expiratory volume in 1 second ( R = 0.430-0.465; p ≤ 0.001) and neuromuscular function. Both cardiorespiratory fitness and neuromuscular function were correlated with self-reported physical functioning and general health status.Conclusions: V o2 max was on average only slightly above the 18 mL·min -1 ·kg -1 , that is, the cut-off value known to induce difficulty in performing daily tasks. Overall, although low physical capacities at admission in ICU COVID-19 patients cannot be ruled out to explain the association between V o2 max or neuromuscular function and ICU stay/MV duration, altered cardiorespiratory fitness and neuromuscular function observed in the present study may not be specific to COVID-19 disease but seem applicable to all ICU/MV patients of similar duration.

Published
2022

23. Cognitive functions and cerebral oxygenation changes during acute and prolonged hypoxic exposure

Author

Stéphane Perrey, Karen Davranche, Thomas Rupp, Pierrick J. Arnal, Samuel Verges, Laurence Casini, Laboratoire de psychologie cognitive (LPC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Université de Lyon, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Euromov (EuroMov), Université de Montpellier (UM), Laboratoire HP2, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Elementary cognitive task, Haemodynamic response, Decision Making, Prefrontal Cortex, Experimental and Cognitive Psychology, Neuropsychological Tests, 050105 experimental psychology, Developmental psychology, Conflict, Psychological, 03 medical and health sciences, Behavioral Neuroscience, [SCCO]Cognitive science, Executive Function, Judgment, 0302 clinical medicine, Cognition, Internal medicine, Surveys and Questionnaires, medicine, Reaction Time, Humans, 0501 psychology and cognitive sciences, Effects of sleep deprivation on cognitive performance, Prefrontal cortex, Hypoxia, ComputingMilieux_MISCELLANEOUS, Spectroscopy, Near-Infrared, [SCCO.NEUR]Cognitive science/Neuroscience, Altitude, 05 social sciences, Time perception, Effects of high altitude on humans, Hypoxia (medical), Adaptation, Physiological, Oxygen, Cerebrovascular Circulation, Time Perception, Cardiology, medicine.symptom, Psychology, 030217 neurology & neurosurgery
Abstract

The present study aimed to assess specific cognitive processes (cognitive control and time perception) and hemodynamic correlates using functional near-infrared spectroscopy (fNIRS) during acute and prolonged high-altitude exposure. Eleven male subjects were transported via helicopter and dropped at 14 272 ft (4 350 meters) of altitude where they stayed for 4 days. Cognitive tasks, involving a conflict task and temporal bisection task, were performed at sea level the week before ascending to high altitude, the day of arrival (D0), the second (D2) and fourth (D4) day at high altitude. Cortical hemodynamic changes in the prefrontal cortex (PFC) area were monitored with fNIRS at rest and during the conflict task. Results showed that high altitude impacts information processing in terms of speed and accuracy. In the early hours of exposure (D0), participants displayed slower reaction times (RT) and decision errors were twice as high. While error rate for simple spontaneous responses remained twice that at sea level, the slow-down of RT was not detectable after 2 days at high-altitude. The larger fNIRS responses from D0 to D2 suggest that higher prefrontal activity partially counteracted cognitive performance decrements. Cognitive control, assessed through the build-up of a top-down response suppression mechanism, the early automatic response activation and the post-error adjustment were not impacted by hypoxia. However, during prolonged hypoxic exposure the temporal judgments were underestimated suggesting a slowdown of the internal clock. A decrease in cortical arousal level induced by hypoxia could consistently explain both the slowdown of the internal clock and the persistence of a higher number of errors after several days of exposure.

Published
2016

24. How 100-m event analyses improve our understanding of world-class men's and women's sprint performance

Author

Giuseppe Rabita, Sylvain Dorel, N. Termoz, Pierre Samozino, Jean-Benoit Morin, Jean Slawinski, Gaël Guilhem, Centre de Recherche sur le Sport et le Mouvement (CeRSM), Université Paris Nanterre (UPN), Institut national du sport, de l'expertise et de la performance (INSEP), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), French Institute of Sport (INSEP), Laboratory Sport, Expertise and Performance (EA7370) (SEP (EA7370)), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Performance, Deceleration, Acceleration, Physical Therapy, Sports Therapy and Rehabilitation, Athletic Performance, Analyse du Mouvement en Biomécanique Physiologie et Imagerie, biomechanics, World class, Running, 03 medical and health sciences, 0302 clinical medicine, Horizontal force, Statistics, gender, sprint running, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Orthopedics and Sports Medicine, Power output, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Mathematics, Event (probability theory), 030229 sport sciences, Biomechanical Phenomena, Sprint, Female, 030217 neurology & neurosurgery
Abstract

Epub ahead of print; This study aimed to compare the force (F)-velocity (v)-power (P)-time (t) relationships of female and male world-class sprinters. A total of 100 distance-time curves (50 women and 50 men) were computed from international 100-m finals, to determine the acceleration and deceleration phases of each race: (a) mechanical variables describing the velocity, force, and power output; and (b) F-P-v relationships and associated maximal power output, theoretical force and velocity produced by each athlete (Pmax , F0 , and V0). The results showed that the maximal sprint velocity (Vmax ) and mean power output (W/kg) developed over the entire 100~m strongly influenced 100-m performance (r>-0.80; P≤q0.001). With the exception of mean force (N/kg) developed during the acceleration phase or during the entire 100~m, all of the mechanicals variables observed over the race were greater in men. Shorter acceleration and longer deceleration in women may explain both their lower Vmax and their greater decrease in velocity, and in turn their lower performance level, which can be explained by their higher V0 and its correlation with performance. This highlights the importance of the capability to keep applying horizontal force to the ground at high velocities.

Published
2015

25. Peroneal reaction time measurement in unipodal stance for two different destabilization axes

Author

Romain Terrier, Nicolas Forestier, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Physique Corpusculaire et Cosmologie - Collège de France ( PCC ), and Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
Adult, Male, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Posture, Biophysics, Kinematics, Electromyography, Standard deviation, 03 medical and health sciences, Time variance, 0302 clinical medicine, Nuclear magnetic resonance, Orientation (geometry), Reaction Time, medicine, Humans, Orthopedics and Sports Medicine, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], Muscle, Skeletal, Postural Balance, ComputingMilieux_MISCELLANEOUS, Simulation, Physics, Proprioception, medicine.diagnostic_test, 030229 sport sciences, medicine.anatomical_structure, Coronal plane, Female, Ankle, Ankle Joint, 030217 neurology & neurosurgery, Muscle Contraction
Abstract

article i nfo Background: The variability of peroneal reaction time measurements is a major problem when using this parameter to control rehabilitation or proprioceptive training processes. In order to control peroneal reaction time values, some extrinsic factors should be considered. The purpose of this study was to measure peroneal reaction time in unipodal stance for two different destabilization axes. Methods: The peroneal reaction time of 10 healthy subjects was measured from kinematic and electromyograhic data in an experimental study using an ankle destabilization device. Findings: Inapreliminaryanalysis,resultsshowedthatthedestabilizationaxisorientationdidnotaffectperoneal reaction time values (68.5 ms, standard deviation=9.5 ms and 71.5 ms, standard deviation=8 ms for destabilizations in the frontal plane and around the Henke's axis, respectively). However, the inter-trial variance of inversion velocity peaks explained between 40% and 49% of the peroneal reaction time variance. When trials were selected on the basis of homogeneous inversion velocity peaks, results showed that peroneal reaction time values for the peroneus brevis were shorter during inversion movements performed around the physiological Henke's tilting axis (63 ms, standard deviation=9 ms vs. 71 ms, standard deviation=8 ms). Interpretation: Our findings evidenced that tilting axis orientation must be considered as an extrinsic factor that may influence peroneal reaction time. Moreover it also seems necessary to consider inversion speed values to adequately compare peroneal reaction time values.

Published
2011

26. Multimodal nutritional rehabilitation improves clinical outcomes of malnourished patients with chronic respiratory failure: a randomised controlled trial

Author

Hubert Roth, Isabelle Court-Fortune, Jean-Paul Janssens, Luis Carlos Molano, Boris Melloni, Thomas Similowski, H. Lejeune, Julie Augustin, Noël Cano, Fabrice Caron, Jésus Gonzalez-Bermejo, Bernard Wuyam, Cécile Chérion, Claude Pichard, Catherine Tardif, Marie-Thérèse Antonini, Lahouari Meziane, Maurice Hayot, Christophe Pison, Frédéric Costes, Public Hospital Medical Service, Ministry of Health [Mozambique], Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Service de Nutrition, CHU Clermont-Ferrand, Service de Pneumologie, Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Hôpital de La Milétrie, Service de Pneumologie [Saint-Etienne], CHU Saint-Etienne, Service d'Explorations Fonctionnelles Physiologiques [CHU Limoges], CHU Limoges, Service de Réanimation et de Pneumologie, Université Pierre et Marie Curie - Paris 6 (UPMC), Service de physiologie clinique, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Muscles et pathologies, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe de Recherche sur le Handicap Ventilatoire (GRHV), Institute for Research and Innovation in Biomedicine (IRIB), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service de pneumologie, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), HP2 - Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire, CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM)-Facultés de médecine et de pharmacie Domaine de la merci, Service de Pneumologie – Réanimation Médicale [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Service de Pathologie respiratoire et allergologie [CHU Limoges], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Université de Lyon, Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RH), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-CHU Saint-Etienne-Hospices Civils de Lyon (HCL)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Department of Clinical Nutrition, Geneva University Hospital (HUG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-CHU Saint-Etienne-Hospices Civils de Lyon (HCL)-CHU Grenoble, The study was investigator driven. Funds came from academic sources (Programme Hospitalier de Recherche Clinique National, Direction Interre´gionale de la Recherche Clinique Rhoˆne-Alpes Auvergne), public foundations (Nutrition 2000Plus), associations (Association Nationale pour les Traitements a` Domicile, les Innovations et la Recherche-ANTADIR, AGIRa`Dom) and pharmaceutical sources (Nutricia Advanced Medical Nutrition, The Netherlands, France, Organon-Schering-Plough, Kenilworth, NJ, USA)., Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie et Oncologie thoracique [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Hamant, Sarah, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
Male, MESH: Combined Modality Therapy, PROGNOSIS, MESH: Exercise Tolerance, Malnutrition/etiology/physiopathology/rehabilitation, medicine.medical_treatment, Respiratory Insufficiency/complications/physiopathology/rehabilitation, Home Care Services, Hospital-Based, MESH: Dietary Supplements, EMPHYSEMA, SUPPLEMENTATION, law.invention, MESH: Health Education, 0302 clinical medicine, Randomized controlled trial, law, TESTOSTERONE, Oxygen therapy, Clinical endpoint, Mass index, 030212 general & internal medicine, Health Education, Health Education/methods, MESH: Treatment Outcome, ddc:616, MESH: Aged, 2. Zero hunger, COPD, Exercise Tolerance, MESH: Middle Aged, Rehabilitation, Middle Aged, MESH: Nutritional Status, Combined Modality Therapy, Exercise Therapy, 3. Good health, Treatment Outcome, FAT MASS, Body Composition, Female, Respiratory Insufficiency, hormones, hormone substitutes, and hormone antagonists, MESH: Malnutrition, Pulmonary and Respiratory Medicine, endocrine system, medicine.medical_specialty, MESH: Testosterone, Nutritional Status, EXERCISE, Testosterone/therapeutic use, OBSTRUCTIVE PULMONARY-DISEASE, MESH: Home Care Services, Hospital-Based, 03 medical and health sciences, Internal medicine, Exercise Tolerance/physiology, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, medicine, Humans, MESH: Exercise Therapy, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Aged, MESH: Humans, business.industry, MESH: Chronic Disease, Malnutrition, MESH: Quality of Life, MESH: Body Composition, medicine.disease, MESH: Male, BODY-MASS INDEX, 030228 respiratory system, Respiratory failure, Chronic Disease, Dietary Supplements, Quality of Life, TERM OXYGEN-THERAPY, Physical therapy, business, MESH: Female, Body mass index, MESH: Respiratory Insufficiency
Abstract

International audience; BACKGROUND: In chronic respiratory failure (CRF), body composition strongly predicts survival. METHODS: A prospective randomised controlled trial was undertaken in malnourished patients with CRF to evaluate the effects of 3 months of home rehabilitation on body functioning and composition. 122 patients with CRF on long-term oxygen therapy and/or non-invasive ventilation (mean (SD) age 66 (10) years, 91 men) were included from eight respiratory units; 62 were assigned to home health education (controls) and 60 to multimodal nutritional rehabilitation combining health education, oral nutritional supplements, exercise and oral testosterone for 90 days. The primary endpoint was exercise tolerance assessed by the 6-min walking test (6MWT). Secondary endpoints were body composition, quality of life after 3 months and 15-month survival. RESULTS: Mean (SD) baseline arterial oxygen tension was 7.7 (1.2) kPa, forced expiratory volume in 1 s 31 (13)% predicted, body mass index (BMI) 21.5 (3.9) kg/m2 and fat-free mass index (FFMI) 15.5 (2.4) kg/m2. The intervention had no significant effect on 6MWT. Improvements (treatment effect) were seen in BMI (+0.56 kg/m2, 95% CI 0.18 to 0.95, p=0.004), FFMI (+0.60 kg/m2, 95% CI 0.15 to 1.05, p=0.01), haemoglobin (+9.1 g/l, 95% CI 2.5 to 15.7, p=0.008), peak workload (+7.2 W, 95% CI 3.7 to 10.6, p

Published
2011

27. Feasibility of a Full-Field Measurements-Based Protocol for the Biomechanical Study of a Lumbar Belt: A Case Study

Author

Rébecca Bonnaire, Woo Suck Han, Reynald Convert, Paul Calmels, Jérôme Molimard, Institut Clément Ader (ICA), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Thuasne, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
DIC, fringe projection, pressure mapping system, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], low back pain, lumbar belt, full-field measurement, [SDV.IB]Life Sciences [q-bio]/Bioengineering, General Medicine
Abstract

International audience; Low back pain represents a major economic and societal challenge due to its high prevalence. Lumbar orthoses are one of the recommended treatments. Even if previous results showed their clinical effects, the detailed mode of action is still poorly known, making the device design difficult. A renewed instrumentation and experimental protocol should bring better insight into the lumbar brace–trunk mechanical interaction. This instrumentation should give detailed information on the basic physical or geometrical parameters: the pressure applied on the trunk, the body shape and the strain in the belt. The principal objective of this study was to propose and validate a new measurement protocol, based on pressure mapping systems and full-field shape and strain measurement. The feasibility of the protocol was tested along with its validity and repeatability. The influence of various parameters, which could cause changes in the measurements, was tested with six different belt configurations on one subject. Measurements were also performed to study the impact of posture on pressure and strain. Both pressure and strain appeared to be asymmetric from left to right. The pressure applied by the lumbar belt on the back varies with breathing and with posture. This study showed that full-field measurements were necessary to render the high variability of pressure or strain around the trunk, under recommendations of their use to guarantee a satisfying repeatability.

Published
2022

28. Unilateral lower limb muscle fatigue induces bilateral effects on undisturbed stance and muscle EMG activities

Author

L. Berger, S.-C. Regueme, Nicolas Forestier, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], medicine.medical_specialty, Posture, Biophysics, Neuroscience (miscellaneous), Isometric exercise, Pain sensation, Postural control, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Lower limb muscle, Physical medicine and rehabilitation, medicine, Humans, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], Muscle, Skeletal, Postural Balance, ComputingMilieux_MISCELLANEOUS, Leg, Muscle fatigue, Electromyography, business.industry, 030229 sport sciences, Body sway, body regions, medicine.anatomical_structure, Muscle Fatigue, Physical therapy, Neurology (clinical), Ankle, business, 030217 neurology & neurosurgery, Muscle Contraction
Abstract

The study investigated the effects of an unilateral ankle muscle fatigue onto independent postural control parameters including the trajectories of the estimated resultant CoP (CoPres) and his components: the centre of gravity (CG) and CoP–CG trajectories. Nine healthy men realized series of 10 toe-lift immediately followed by 10 knee flexions until exhaustion with one (Ex) leg. Maximal isometric voluntary contractions, postural sway measures of each leg, and muscular activities of the ankle muscles were recorded before and immediately after the fatiguing exercise. As expected, the latter induced a decrease in maximal voluntary peak force associated with a greater variability of the relative contribution of each leg on the CoPres, enhanced all postural parameters of the non-exercised leg. A significant decreased of the tibialis anterior EMG activity for the Ex leg and an increased one for the NoEx leg. Finally, following unilateral fatigue, the body sway destabilisation seemed to occur only along the medio-lateral (ML) axis. The enhanced and greater variability of the variance along ML axis might be explained by the recourse at the loading–unloading strategy choice and suggests a central attempt to compensate for pain sensation.

Published
2010

29. Dynamin 2 and human diseases

Author

Anne-Cécile Durieux, Bernard Prudhon, Pascale Guicheney, Marc Bitoun, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut de Myologie, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Pierre et Marie Curie - Paris 6 (UPMC), Coeur, Muscle et Vaisseaux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Endosome, [SDV]Life Sciences [q-bio], Golgi Apparatus, Endosomes, Biology, Endocytosis, Exocytosis, Dynamin II, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Charcot-Marie-Tooth Disease, Drug Discovery, medicine, Animals, Humans, Centronuclear myopathy, Autosomal dominant centronuclear myopathy, Cytoskeleton, Genetics (clinical), Genes, Dominant, 030304 developmental biology, Dynamin, 0303 health sciences, Cell Membrane, Peripheral Nervous System Diseases, Intracellular vesicle, Anatomy, Golgi apparatus, medicine.disease, Axons, Clathrin, 3. Good health, Cell biology, symbols, Molecular Medicine, 030217 neurology & neurosurgery, Myopathies, Structural, Congenital
Abstract

International audience; Dynamin 2 (DNM2) mutations cause autosomal dominant centronuclear myopathy (CNM), a rare form of congenital myopathy, and intermediate and axonal forms of Charcot-Marie-Tooth disease (CMT), a peripheral neuropathy. DNM2 is a large GTPase mainly involved in membrane trafficking through its function in the formation and release of nascent vesicles from biological membranes. DNM2 participates in clathrin-dependent and clathrin-independent endocytosis and intracellular membrane trafficking (from endosomes and Golgi apparatus). Recent studies have also implicated DNM2 in exocytosis. DNM2 belongs to the machinery responsible for the formation of vesicles and regulates the cytoskeleton providing intracellular vesicle transport. In addition, DNM2 tightly interacts with, and is involved in the regulation of actin and microtubule networks, independent from membrane trafficking processes. We summarize here the molecular, biochemical and functional data on DNM2 and discuss the possible pathophysiological mechanisms via which DNM2 mutations can lead to two distinct neuromuscular disorders.

Published
2010

30. Anodal transcranial direct current stimulation enhances the effects of motor imagery training in a finger tapping task

Author

Francine Malouin, Catherine Mercier, Aymeric Guillot, Philip L. Jackson, Christian Collet, Julien Doyon, Arnaud Saimpont, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale (CIRRIS), Université Laval [Québec] (ULaval), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Psychology, University of Glasgow, and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Adult, Male, Anodal tdcs, medicine.medical_specialty, medicine.medical_treatment, Motor Activity, Transcranial Direct Current Stimulation, Motor function, 050105 experimental psychology, Fingers, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Motor imagery, Physical medicine and rehabilitation, Double-Blind Method, Neuromodulation, medicine, Humans, Learning, 0501 psychology and cognitive sciences, Muscle, Skeletal, ComputingMilieux_MISCELLANEOUS, Transcranial direct-current stimulation, General Neuroscience, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Motor Cortex, medicine.anatomical_structure, Finger tapping, Imagination, Female, Analysis of variance, Primary motor cortex, Psychology, Neuroscience, 030217 neurology & neurosurgery
Abstract

Motor imagery (MI) training and anodal transcranial direct current stimulation (tDCS) applied over the primary motor cortex can independently improve hand motor function. The main objective of this double-blind, sham-controlled study was to examine whether anodal tDCS over the primary motor cortex could enhance the effects of MI training on the learning of a finger tapping sequence. Thirty-six right-handed young human adults were assigned to one of three groups: (i) who performed MI training combined with anodal tDCS applied over the primary motor cortex; (ii) who performed MI training combined with sham tDCS; and (iii) who received tDCS while reading a book. The MI training consisted of mentally rehearsing an eight-item complex finger sequence for 13 min. Before (Pre-test), immediately after (Post-test 1), and at 90 min after (Post-test 2) MI training, the participants physically repeated the sequence as fast and as accurately as possible. An anova showed that the number of sequences correctly performed significantly increased between Pre-test and Post-test 1 and remained stable at Post-test 2 in the three groups (P

Published
2015

31. A pilot study on quantification of training load: The use of HRV in training practice

Author

Pascal Balducci, Christophe Hautier, Damien Saboul, Vincent Pialoux, Grégoire P. Millet, Almerys, Institut des Systèmes Intelligents et de Robotique (ISIR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Lyon, and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Physical Therapy, Sports Therapy and Rehabilitation, Pilot Projects, Autonomic Nervous System, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Medicine, Heart rate variability, Humans, Orthopedics and Sports Medicine, Training load, Exercise duration, Exercise, ComputingMilieux_MISCELLANEOUS, Fatigue, business.industry, 030229 sport sciences, General Medicine, Intensity (physics), Physical therapy, Exercise intensity, Exercise Test, Linear Models, business, 030217 neurology & neurosurgery, circulatory and respiratory physiology, Field conditions, Recovery phase
Abstract

Recent laboratory studies have suggested that heart rate variability (HRV) may be an appropriate criterion for training load (TL) quantification. The aim of this study was to validate a novel HRV index that may be used to assess TL in field conditions. Eleven well-trained long-distance male runners performed four exercises of different duration and intensity. TL was evaluated using Foster and Banister methods. In addition, HRV measurements were performed 5 minutes before exercise and 5 and 30 minutes after exercise. We calculated HRV index (TLHRV) based on the ratio between HRV decrease during exercise and HRV increase during recovery. HRV decrease during exercise was strongly correlated with exercise intensity (R = -0.70; p0.01) but not with exercise duration or training volume. TLHRV index was correlated with Foster (R = 0.61; p = 0.01) and Banister (R = 0.57; p = 0.01) methods. This study confirms that HRV changes during exercise and recovery phase are affected by both intensity and physiological impact of the exercise. Since the TLHRV formula takes into account the disturbance and the return to homeostatic balance induced by exercise, this new method provides an objective and rational TL index. However, some simplification of the protocol measurement could be envisaged for field use.

Published
2015

32. Compensation of lateralized fatigue due to referent static positional signals in an ankle-matching task

Author

François Bonnetblanc, Nicolas Forestier, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], medicine.medical_specialty, Matching (statistics), Proprioception, medicine.diagnostic_test, business.industry, General Neuroscience, Feed forward, 030229 sport sciences, Isometric exercise, Electromyography, Compensation (engineering), Task (project management), 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Physical medicine and rehabilitation, Physical therapy, Medicine, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], Ankle, business, ComputingMilieux_MISCELLANEOUS, 030217 neurology & neurosurgery
Abstract

The main objective of this study was to examine whether static and dynamic signals from a non-fatigued reference ankle can differently improve the movement accuracy of a fatigued ankle. To address this question, subjects performed an ankle-matching task in a control condition and in a condition of local fatigue induced in the right tibialis anterior, in two matching conditions. In a bilateral condition, the matching task was completed with the two ankles simultaneously. In a unilateral condition subjects had to match the exact target position with the left non-fatigued ankle first and then tried to match the target position with the right fatigued ankle. Results showed that the final accuracy of the right fatigued ankle was degraded when matched with both ankles simultaneously while, for the unilateral condition, the final accuracy remained constant whether the ankle was fatigued or not. In addition, the EMG activity of the right tibialis increased significantly in the acceleration portion of the ankle movement for the unilateral condition. These results suggest that the CNS was able to integrate the correct static positional signals originating from the left reference ankle, to improve the movement accuracy of the controlateral fatigued ankle. This compensation of lateralized fatigue is operated in a feedforward manner.

Published
2006

33. Hypothalamic–pituitary–adrenal axis activation and glucocorticoid‐responsive gene expression in skeletal muscle and liver of Apc mice

Author

Agnès Martin, Josiane Castells, Valentine Allibert, Andréa Emerit, Cindy Zolotoff, Victoire Cardot‐Ruffino, Yann S. Gallot, Barbara Vernus, Véronique Chauvet, Laurent Bartholin, Laurent Schaeffer, Anne‐Cécile Durieux, Christophe Hourdé, François B. Favier, Laetitia Mazelin, Damien Freyssenet, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut NeuroMyoGène (INMG), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Dynamique Musculaire et Métabolisme (DMEM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Montpellier (UM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Ligue Nationale contre le Cancer (Comité Saône et Loire), Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation MESRI, Fondation ARC pour la Recherche sur le Cancer, Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées (IRBA), and Raynaud, Christelle

Subjects
Male, Hypothalamo-Hypophyseal System, Cachexia, [SDV]Life Sciences [q-bio], Gene Expression, Pituitary-Adrenal System, Skeletal muscle, Cancer cachexia, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, Carcinoma, Lewis Lung, Mice, Glucocorticoid, Metabolism, Liver, Physiology (medical), Hypothalamic-pituitary-adrenal axis, Quality of Life, Animals, Humans, Orthopedics and Sports Medicine, Muscle, Skeletal, Glucocorticoids, Aged
Abstract

Cancer patients at advanced stages experience a severe depletion of skeletal muscle compartment together with a decrease in muscle function, known as cancer cachexia. Cachexia contributes to reducing quality of life, treatment efficiency, and lifespan of cancer patients. However, the systemic nature of the syndrome is poorly documented. Here, we hypothesize that glucocorticoids would be important systemic mediators of cancer cachexia.To explore the role of glucocorticoids during cancer cachexia, biomolecular analyses were performed on several tissues (adrenal glands, blood, hypothalamus, liver, and skeletal muscle) collected from ApcTwenty-three-week-old Apc mice recapitulated important features of cancer cachexia including body weight loss (-16%, P 0.0001), muscle atrophy (gastrocnemius muscle: -53%, P 0.0001), and weakness (-50% in tibialis anterior muscle force, P 0.0001), increased expression of atrogens (7-fold increase in MuRF1 transcript level, P 0.0001) and down-regulation of Akt-mTOR pathway (3.3-fold increase in 4EBP1 protein content, P 0.0001), together with a marked transcriptional rewiring of hepatic metabolism toward an increased expression of gluconeogenic genes (Pcx: +90%, Pck1: +85%), and decreased expression of glycolytic (Slc2a2: -40%, Gk: -30%, Pklr: -60%), ketogenic (Hmgcs2: -55%, Bdh1: -80%), lipolytic/fatty oxidation (Lipe: -50%, Mgll: -60%, Cpt2: -60%, Hadh: -30%), and lipogenic (Acly: -30%, Acacb: -70%, Fasn: -45%) genes. The hypothalamic pituitary-adrenal axis was activated, as evidenced by the increase in the transcript levels of genes encoding corticotropin-releasing hormone in the hypothalamus (2-fold increase, P 0.01), adrenocorticotropic hormone receptor (3.4-fold increase, P 0.001), and steroid biosynthesis enzymes (Cyp21a1, P 0.0001, and Cyp11b1, P 0.01) in the adrenal glands, as well as by the increase in corticosterone level in the serum (+73%, P 0.05), skeletal muscle (+17%, P 0.001), and liver (+24%, P 0.05) of cachectic 23-week-old Apc mice. A comparative transcriptional analysis with dexamethasone-treated C57BL/6J mice indicated that the activation of the hypothalamic-pituitary-adrenal axis in 23-week-old ApcThese findings highlight the role of the hypothalamic-pituitary-adrenal-glucocorticoid pathway in the transcriptional regulation of skeletal muscle catabolism and hepatic metabolism during cancer cachexia. They also provide the paradigm for the design of new therapeutic strategies.

Published
2022

34. Acid-base balance at high altitude in lowlanders and indigenous highlanders

Author

Michael M. Tymko, Christopher K. Willie, Connor A. Howe, Ryan L. Hoiland, Rachel M. Stone, Kaitlyn Tymko, Courtney Tymko, David MacLeod, James D. Anholm, Christopher Gasho, Francisco Villafuerte, Gustavo Vizcardo-Galindo, Romulo Figueroa-Mujica, Trevor A. Day, Jordan D. Bird, Glen E. Foster, Craig D. Steinback, Julien V. Brugniaux, Benoit Champigneulle, Emeric Stauffer, Stephane Doutreleau, Samuel Verges, Erik R. Swenson, Philip N. Ainslie, University of British Columbia (UBC), University of Alberta, Vancouver General Hospital [Vancouver, British Columbia, Canada] (VGH), University of Windsor [Ca], University of Manitoba [Winnipeg], Duke University Medical Center, Loma Linda University, Universidad Peruana Cayetano Heredia (UPCH), Université Mount Royal/Mount Royal University [Calgary, AB, Canada] (MRU), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), CHU Grenoble, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), University of Washington [Seattle], and SALAS, Danielle

Subjects
Renal compensation, Acid-Base Equilibrium, Acid-base balance, hypoxia, renal compensation, Physiology, [SDV]Life Sciences [q-bio], Acclimatization, Altitude, Indigenous highlanders, acid-base balance, Altitude Sickness, indigenous highlanders, [SDV] Life Sciences [q-bio], Physiology (medical), high altitude, parasitic diseases, High altitude, Expeditions, Humans, Hypoxia
Abstract

International audience; High-altitude exposure results in a hyperventilatory-induced respiratory alkalosis followed by renal compensation (bicarbonaturia) to return arterial blood pH (pHa) toward sea-level values. However, acid-base balance has not been comprehensively examined in both lowlanders and indigenous populations-where the latter are thought to be fully adapted to high altitude. The purpose of this investigation was to compare acid-base balance between acclimatizing lowlanders and Andean and Sherpa highlanders at various altitudes (∼3,800, ∼4,300, and ∼5,000 m). We compiled data collected across five independent high-altitude expeditions and report the following novel findings: 1) at 3,800 m, Andeans (n = 7) had elevated pHa compared with Sherpas (n = 12; P < 0.01), but not to lowlanders (n = 16; 9 days acclimatized; P = 0.09); 2) at 4,300 m, lowlanders (n = 16; 21 days acclimatized) had elevated pHa compared with Andeans (n = 32) and Sherpas (n = 11; both P < 0.01), and Andeans had elevated pHa compared with Sherpas (P = 0.01); and 3) at 5,000 m, lowlanders (n = 16; 14 days acclimatized) had higher pHa compared with both Andeans (n = 66) and Sherpas (n = 18; P < 0.01, and P = 0.03, respectively), and Andean and Sherpa highlanders had similar blood pHa (P = 0.65). These novel data characterize acid-base balance acclimatization and adaptation to various altitudes in lowlanders and indigenous highlanders.NEW & NOTEWORTHY Lowlander, Andean, and Sherpa arterial blood data were combined across five independent high-altitude expeditions in the United States, Nepal, and Peru to assess acid-base status at ∼3,800, ∼4,300, and ∼5,000 m. The main finding was that Andean and Sherpa highlander populations have more acidic arterial blood, due to elevated arterial carbon dioxide and similar arterial bicarbonate compared with acclimatizing lowlanders at altitudes ≥4,300 m.

Published
2022

35. Resting and active motor thresholds versus stimulus–response curves to determine transcranial magnetic stimulation intensity in quadriceps femoris

Author

John Temesi, Samuel Verges, Thomas Rupp, Mathieu Gruet, Guillaume Y. Millet, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Laboratoire HP2, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Human Performance, University of Calgary, Rhône-Alpes Region, Fonds de Dotation Recherche en Santé Respiratoire, appel d'offres 2011, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, Laboratoire Motricité Humaine Expertise Sport Santé ( LAMHESS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Université de Toulon ( UTLN ), Institut National de la Santé et de la Recherche Médicale ( INSERM ), BMC, Ed., Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, genetic structures, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Vastus medialis, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, medicine.medical_treatment, Health Informatics, Stimulation, Electromyography, Stimulus (physiology), Stimulus intensity determination, Quadriceps Muscle, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Humans, Methodological considerations, Fatigue, medicine.diagnostic_test, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Research, Rehabilitation, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Motor Cortex, 030229 sport sciences, Evoked Potentials, Motor, C600, Transcranial Magnetic Stimulation, Coactivation, body regions, Transcranial magnetic stimulation, medicine.anatomical_structure, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Physical therapy, medicine.symptom, Psychology, human activities, 030217 neurology & neurosurgery, Muscle Contraction, Muscle contraction, Motor cortex
Abstract

International audience; BACKGROUND: Transcranial magnetic stimulation (TMS) is a widely-used investigative technique in motor cortical evaluation. Recently, there has been a surge in TMS studies evaluating lower-limb fatigue. TMS intensity of 120-130% resting motor threshold (RMT) and 120% active motor threshold (AMT) and TMS intensity determined using stimulus-response curves during muscular contraction have been used in these studies. With the expansion of fatigue research in locomotion, the quadriceps femoris is increasingly of interest. It is important to select a stimulus intensity appropriate to evaluate the variables, including voluntary activation, being measured in this functionally important muscle group. This study assessed whether selected quadriceps TMS stimulus intensity determined by frequently employed methods is similar between methods and muscles. METHODS: Stimulus intensity in vastus lateralis, rectus femoris and vastus medialis muscles was determined by RMT, AMT (i.e. during brief voluntary contractions at 10% maximal voluntary force, MVC) and maximal motor-evoked potential (MEP) amplitude from stimulus-response curves during brief voluntary contractions at 10, 20 and 50% MVC at different stimulus intensities. RESULTS: Stimulus intensity determined from a 10% MVC stimulus-response curve and at 120 and 130% RMT was higher than stimulus intensity at 120% AMT (lowest) and from a 50% MVC stimulus-response curve (p < 0.05). Stimulus intensity from a 20% MVC stimulus-response curve was similar to 120% RMT and 50% MVC stimulus-response curve. Mean stimulus intensity for stimulus-response curves at 10, 20 and 50% MVC corresponded to approximately 135, 115 and 100% RMT and 180, 155 and 130% AMT, respectively. Selected stimulus intensity was similar between muscles for all methods (p > 0.05). CONCLUSIONS: Similar optimal stimulus intensity and maximal MEP amplitudes at 20 and 50% MVC and the minimal risk of residual fatigue at 20% MVC suggest that a 20% MVC stimulus-response curve is appropriate for determining TMS stimulus intensity in the quadriceps femoris. The higher selected stimulus intensities at 120-130% RMT have the potential to cause increased coactivation and discomfort and the lower stimulus intensity at 120% AMT may underestimate evoked responses. One muscle may also act as a surrogate in determining optimal quadriceps femoris stimulation intensity.

Published
2014

36. Prognosis of Old Intensive Care COVID-19 Patients at a Glance: The Senior COVID Study

Author

Vacheron, C. H., Bitker, L., Thiolliere, F., Subtil, F., Ábrahám, P., Collange, V., Balança, B., Haine, M., Guichon, C., Leroy, C., Simon, M., Malapert, A., Roche, M., Pialat, J. B., Jallades, L., Lepape, A., Friggeri, A., Falandry, C., Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Pôle de Santé Publique [Lyon], Hôpital de la Croix-Rousse [CHU - HCL], Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Université de Lyon, Médipôle Lyon-Villeurbanne (MLV), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hôpital Nord-Ouest de Villefranche-sur-Saône [Gleize] (HNOVS), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre Hospitalier Emile Roux [Le Puy-en-Velay] (CH Le Puy-en-Velay), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Henry Gabrielle [CHU - HCL], Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and CarMeN, laboratoire

Subjects
[SDV] Life Sciences [q-bio], Anesthesiology and Pain Medicine, General Veterinary, Ecology, [SDV]Life Sciences [q-bio], Animal Science and Zoology, Forestry, Surgery, Plant Science, Horticulture, General Agricultural and Biological Sciences, General Psychology
Abstract

International audience; OBJECTIVE: Admission in the intensive care unit of the old patient with coronavirus disease 19 raises an ethical question concerning the scarce resources and their short-term mortality. METHODS: Patients aged over 60 from 7 different intensive care units admitted between March 1, 2020 and May 6, 2020, with a diagnosis of coronavirus disease 19 were included in the cohort. Twenty variables were collected during the admission, such as age, severity (Simplified Acute Physiology Score [SAPS] II), several data on physiological status before intensive care unit comorbidities, evaluation of autonomy, frailty, and biological variables. The objective was to model the 30-day mortality with relevant variables, compute their odds ratio associated with their 95% CI, and produce a nomogram to easily estimate and communicate the 30-day mortality. The performance of the model was estimated with the area under the receiving operating curve. RESULTS: We included 231 patients, among them 60 (26.0%) patients have died on the 30th day. The relevant variables selected to explain the 30-day mortality were Instrumental Activities of Daily Living (IADL) score (0.82 [0.71-0.94]), age 1.12 (1.07-1.18), SAPS II 1.05 (1.02-1.08), and dementia 6.22 (1.00-38.58). A nomogram was computed to visually represent the final model. Area under the receiving operating curve was at 0.833 (0.776-0.889). CONCLUSIONS: Age, autonomy, dementia, and severity at admission were important predictive variables for the 30-day mortality status, and the nomogram could help the physician in the decision-making process and the communication with the family.

Published
2022

37. Reliability of isokinetic assessment of shoulder-rotator strength: a systematic review of the effect of position

Author

Vincent Gremeaux, Sophie Gleizes Cervera, Paul Calmels, Pascal Edouard, Marc Julia, William Vanbiervliet, Pierre Samozino, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Service de médecine physique et de réadaptation ( MPR ), Hôpital Bellevue, CHU de Saint-Étienne, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Gremeaux, Vincent, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Service de médecine physique et de réadaptation (MPR), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
medicine.medical_specialty, Shoulder, Supine position, Intraclass correlation, Posture, Biophysics, Physical Therapy, Sports Therapy and Rehabilitation, Context (language use), Sitting, 03 medical and health sciences, Rotator Cuff, 0302 clinical medicine, Physical medicine and rehabilitation, Medicine, Humans, Orthopedics and Sports Medicine, Muscle Strength, 10. No inequality, Reliability (statistics), 030222 orthopedics, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Rehabilitation, [SCCO.NEUR] Cognitive science/Neuroscience, Reproducibility of Results, 030229 sport sciences, Position (obstetrics), Coronal plane, [ SCCO.NEUR ] Cognitive science/Neuroscience, business, Evidence synthesis, Muscle Contraction
Abstract

Context:Isokinetic assessment of shoulder internal- (IR) and external-rotator (ER) strength is commonly used with many different postures (sitting, standing, or supine) and shoulder positions (frontal or scapular plane with 45° or 90° of abduction).Objective:To conduct a systematic review to determine the influence of position on the intersession reliability of the assessment of IR and ER isokinetic strength, to identify the most reliable position, and to determine which isokinetic variable appears to be most stable in intersession reliability.Evidence Acquisition:A systematic literature search through MEDLINE and Pascal Biomed databases was performed in October 2009. Criteria for inclusion were that studies be written in English or French, describe the isokinetic evaluation methods, and describe statistical analysis.Evidence Synthesis:Sixteen studies meeting the inclusion criteria were included. Variable reliability of ER and IR peak torque (PT) were generally reported for all assessment positions; intraclass correlation coefficients were .44–.98 in the seated position with 45° of shoulder abduction, .09–.77 in the seated position with 90° of shoulder abduction, .86–.99 (coefficient of variation: 7.5–29.8%) in the supine position with 90° of shoulder abduction, .82–.84 in the supine position with 45° of shoulder abduction, and .75–.94 in standing. The ER:IR ratio reliability was low for all positions.Conclusions:The seated position with 45° of shoulder abduction in the scapular plane seemed the most reliable for IR and ER strength assessment. The standing position or a shoulder posture with 90° of shoulder abduction or in the frontal plane must be used with caution given the low reliability for peak torque. Good reliability of ER and IR PT was generally reported, but ER:IR ratio reliability was low.

Published
2011

38. Pulmonary arterial systolic pressure and susceptibility to high altitude pulmonary edema

Author

Rémi Mounier, Jean Coudert, Nicolas Caillot, Bernard Citron, Cécile Gladine, Erica N. Chirico, Aimé Amonchot, Vincent Pialoux, Mario Bedu, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Paris Descartes - Paris 5 (UPD5), Departement Nephrologie, CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Physiologie-Biologie du Sport, Université d'Auvergne - Clermont-Ferrand I (UdA), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Clermont-Ferrand, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)

Subjects
Male, Vascular Endothelial Growth Factor A, [SDV]Life Sciences [q-bio], Hemodynamics, Blood Pressure, 030204 cardiovascular system & hematology, Doppler echocardiography, Altitude Sickness, 0302 clinical medicine, Edema, Malondialdehyde, High-altitude pulmonary edema, echocardiography, Hypoxia, ComputingMilieux_MISCELLANEOUS, medicine.diagnostic_test, General Neuroscience, Middle Aged, Echocardiography, Doppler, 3. Good health, medicine.anatomical_structure, Anesthesia, Female, Disease Susceptibility, medicine.symptom, Pulmonary and Respiratory Medicine, Adult, Hypertension, Pulmonary, Physical exercise, Enzyme-Linked Immunosorbent Assay, Pulmonary Artery, 03 medical and health sciences, Young Adult, medicine, Humans, altitude pulmonary disease, RNA, Messenger, Exercise, Nitrites, Lung, Nitrates, business.industry, 030229 sport sciences, Hypoxia (medical), medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, respiratory system, Blood pressure, physiology, business
Abstract

International audience; There is evidence that pulmonary arterial hypertension plays a major role in the occurrence of high altitude pulmonary edema (HAPE). We tested the hypothesis that the pulmonary arterial systolic pressure response to a challenge associated with hypoxia and mild exercise may be considered a predictive factor of HAPE. Pulmonary arterial systolic pressure was measured by Doppler echocardiography in 8 HAPE susceptible (HAPE-S) subjects and 8 HAPE resistant mountaineers (HAPE-R) during a hypoxic exercise challenge established by the French Association for Sport Medicine (Richalet's test). Pulmonary arterial systolic pressure during hypoxic exercise allowed a significant discrimination between the groups, although an overlap of values was observed. When expressed as individual variations from baseline to hypoxic exercise level however, we found a highly significant difference. No overlap was observed between HAPE-R (range: 6.7-18.5 mmHg) and HAPE-S (range: 19.2-30.4 mmHg) groups, with a cut-off value at 19 mmHg. Plasma Vascular Endothelial growth factor (VEGF) and malondialdehyde (MDA) increased in response to hypoxic exercise only in HAPE-S group. Individual increases in pulmonary arterial systolic pressure during hypoxic exercise from basal resting normoxic values seem relevant to estimate HAPE susceptibility when measured during the Richalet's test.

Published
2011

39. Editorial: Lactate as a Major Signaling Molecule for Homeostasis

Author

Luc Pellerin, Philippe Connes, Catherine Bisbal, Karen Lambert, MORNET, Dominique, Ischémie Reperfusion, Métabolisme et Inflammation Stérile en Transplantation (IRMETIST), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

Subjects
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Physiology, Physiology (medical), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

40. Effect of terminal accuracy requirements on temporal gaze-hand coordination during fast discrete and reciprocal pointings

Author

Normand Teasdale, Martin Lavallière, Nicolas Forestier, Mathieu Germain-Robitaille, Félix Berrigan, Romain Terrier, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Laval University [Québec], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), and Université Laval [Québec] (ULaval)

Subjects
Adult, Male, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Eye Movements, Movement, Health Informatics, Fixation, Ocular, 050105 experimental psychology, lcsh:RC321-571, 03 medical and health sciences, Ocular physiology, 0302 clinical medicine, Reaction Time, Humans, 0501 psychology and cognitive sciences, Computer vision, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Simulation, ComputingMilieux_MISCELLANEOUS, Analysis of Variance, business.industry, Research, 05 social sciences, Rehabilitation, Data interpretation, Eye movement, Hand, Gaze, Biomechanical Phenomena, Data Interpretation, Statistical, Head Movements, Fixation (visual), Calibration, Head movements, Artificial intelligence, business, Psychology, 030217 neurology & neurosurgery, Reciprocal, Algorithms, Photic Stimulation, Psychomotor Performance
Abstract

Background Rapid discrete goal-directed movements are characterized by a well known coordination pattern between the gaze and the hand displacements. The gaze always starts prior to the hand movement and reaches the target before hand velocity peak. Surprisingly, the effect of the target size on the temporal gaze-hand coordination has not been directly investigated. Moreover, goal-directed movements are often produced in a reciprocal rather than in a discrete manner. The objectives of this work were to assess the effect of the target size on temporal gaze-hand coordination during fast 1) discrete and 2) reciprocal pointings. Methods Subjects performed fast discrete (experiment 1) and reciprocal (experiment 2) pointings with an amplitude of 50 cm and four target diameters (7.6, 3.8, 1.9 and 0.95 cm) leading to indexes of difficulty (ID = log2[2A/D]) of 3.7, 4.7, 5.7 and 6.7 bits. Gaze and hand displacements were synchronously recorded. Temporal gaze-hand coordination parameters were compared between experiments (discrete and reciprocal pointings) and IDs using analyses of variance (ANOVAs). Results Data showed that the magnitude of the gaze-hand lead pattern was much higher for discrete than for reciprocal pointings. Moreover, while it was constant for discrete pointings, it decreased systematically with an increasing ID for reciprocal pointings because of the longer duration of gaze anchoring on target. Conclusion Overall, the temporal gaze-hand coordination analysis revealed that even for high IDs, fast reciprocal pointings could not be considered as a concatenation of discrete units. Moreover, our data clearly illustrate the smooth adaptation of temporal gaze-hand coordination to terminal accuracy requirements during fast reciprocal pointings. It will be interesting for further researches to investigate if the methodology used in the experiment 2 allows assessing the effect of sensori-motor deficits on gaze-hand coordination.

Published
2010

41. The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors

Author

Guillaume Y. Millet, Tristan Martin, S. Nicole Culos-Reed, Rosie Twomey, Mary E. Medysky, John Temesi, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), University of Calgary, Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN), University of Brighton, Oregon Health and Science University [Portland] (OHSU), University of Northumbria at Newcastle [United Kingdom], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Martin, Tristan, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Le Mans Université (UM)

Subjects
insomnia, [SDV]Life Sciences [q-bio], 0302 clinical medicine, Cancer Survivors, Neoplasms, Insomnia, Medicine, Cancer-related fatigue, Fatigue, RC254-282, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Sleep in non-human animals, humanities, SportRxiv|Rehabilitation and Therapy|Medicine and Health, 3. Good health, [SDV] Life Sciences [q-bio], bepress|Social and Behavioral Sciences|Sociology, SportRxiv|Sport and Exercise Science, 030220 oncology & carcinogenesis, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Sleep onset, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], medicine.medical_specialty, Rest, bepress|Life Sciences|Kinesiology, bepress|Medicine and Health Sciences|Rehabilitation and Therapy, B100, [SDV.CAN]Life Sciences [q-bio]/Cancer, Article, 03 medical and health sciences, SportRxiv|Rehabilitation and Therapy, [SDV.CAN] Life Sciences [q-bio]/Cancer, Humans, bepress|Medicine and Health Sciences|Rehabilitation and Therapy|Other Rehabilitation and Therapy, SportRxiv|Rehabilitation and Therapy|Other Rehabilitation and Therapy, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], SportRxiv|Sport and Exercise Science|Physical Activity, 030304 developmental biology, [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], business.industry, Cancer, Actigraphy, cancer-related fatigue, Rest activity, medicine.disease, C600, B900, Physical therapy, rest–activity cycle, Sleep onset latency, Sleep, business, 030217 neurology & neurosurgery, actigraphy
Abstract

Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest–activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest–activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Cancer survivors (n = 87) completed a 14-day wrist actigraphy measurement to estimate their sleep and rest–activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued n = 51 and non-fatigued n = 36). The participant’s perception of sleep was measured using the Insomnia Severity Index (ISI). FACIT-F score was correlated with wake after sleep onset (r = −0.28, p = 0.010), sleep efficiency (r = 0.26, p = 0.016), sleep onset latency (r = −0.31, p = 0.044) and Insomnia Severity Index (ISI) score (r = −0.56, p &lt, 0.001). The relative amplitude of the rest–activity cycles was lower in the fatigued vs. the non-fatigued group (p = 0.017, d = 0.58). After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest–activity cycle disruption in people experiencing clinically-relevant fatigue.

Published
2021

42. Do mechanical gait parameters explain the higher metabolic cost of walking in obese adolescents?

Author

Nicolas Peyrot, Laurie Isacco, Jean-Benoit Morin, Pascale Duché, Alain Belli, David Thivel, Impact de l'Activité Physique sur la Santé (IAPS), Université de Toulon (UTLN), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université Blaise Pascal - Clermont-Ferrand 2 (UBP), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Male, medicine.medical_specialty, Adolescent, Physiology, 030209 endocrinology & metabolism, Walking, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Physiology (medical), medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Obesity, Exercise physiology, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Child, Exercise, Gait, Mechanical energy, business.industry, Work (physics), Body Weight, 030229 sport sciences, medicine.disease, Metabolic cost, Metabolic rate, Physical therapy, Body Composition, Exercise Test, Female, business, Energy Metabolism, Body mass index
Abstract

Net metabolic cost of walking normalized by body mass ( CW·BM−1; in J·kg−1·m−1) is greater in obese than in normal-weight individuals, and biomechanical differences could be responsible for this greater net metabolic cost. We hypothesized that, in obese individuals, greater mediolateral body center of mass (COM) displacement and lower recovery of mechanical energy could induce an increase in the external mechanical work required to lift and accelerate the COM and thus in net CW·BM−1. Body composition and standing metabolic rate were measured in 23 obese and 10 normal-weight adolescents. Metabolic and mechanical energy costs were assessed while walking along an outdoor track at four speeds (0.75–1.50 m/s). Three-dimensional COM accelerations were measured by means of a tri-axial accelerometer and gyroscope and integrated twice to obtain COM velocities, displacements, and fluctuations in potential and kinetic energies. Last, external mechanical work (J·kg−1·m−1), mediolateral COM displacement, and the mechanical energy recovery of the inverted pendulum were calculated. Net CW·BM−1was 25% higher in obese than in normal-weight subjects on average across speeds, and net CW·BM−67(J·kg−0.67·m−1) was significantly related to percent body fat ( r2= 0.46). However, recovery of mechanical energy and the external work performed (J·kg−1·m−1) were similar in the two groups. The mediolateral displacement was greater in obese subjects and significantly related to percent body fat ( r2= 0.64). The mediolateral COM displacement, likely due to greater step width, was significantly related to net CW·BM−67( r2= 0.49). In conclusion, we speculate that the greater net CW·BM−67in obese subjects may be partially explained by the greater step-to-step transition costs associated with wide gait during walking.

Published
2009

43. Outcomes of isolated soft tissue surgery for in-toeing gait in patients with ambulatory cerebral palsy

Author

Elie Haddad, Marion Zemour, Bérénice Zagorda-Pallandre, Bruno Dohin, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
medicine.medical_specialty, Adolescent, [SDV]Life Sciences [q-bio], Cerebral palsy, 03 medical and health sciences, 0302 clinical medicine, medicine, Spastic, Humans, Orthopedics and Sports Medicine, Femur, Prospective Studies, Spasticity, Gait, Retrospective Studies, Muscle contracture, Metatarsus Varus, 030222 orthopedics, biology, business.industry, Cerebral Palsy, Gluteus minimus, Soft tissue, 030229 sport sciences, medicine.disease, biology.organism_classification, Surgery, Treatment Outcome, Gait analysis, medicine.symptom, business
Abstract

BACKGROUND Soft tissue surgery to address in-toeing gait in young cerebral palsy (CP) patients may be an alternative in some cases to femoral derotation osteotomy (FDO), which is the currently accepted treatment. The relative contribution of muscular contracture, spasticity and bone deformity is still controversial. In this study, we determined the outcomes of soft tissue surgery on hip internal rotation (HIR) when femoral anteversion was less than 45° and the soft tissues were identified as being the cause. METHODS This prospective study included select adolescent patients who were operated in the context of single-event multilevel surgery. The soft tissues' contribution to the HIR was identified beforehand. The surgical procedures focused on the hamstrings, adductor magnus and gluteus minimus muscles. RESULTS Over a 6-year period, 21 patients (mean age 14 years) and 25 lower limbs were treated. The HIR improved by an average of 17.4°±4.8° (95% CI). The gait deviation index and gait profile score also improved significantly. At a mean follow-up of 36 months, no loss of correction had occurred. DISCUSSION In-toeing gait in CP patents is due to the action of retracted and/or spastic muscles and the presence of excessive bone torsion. When femoral anteversion

Published
2020

44. Impact of the Menstrual Cycle Phases on the Movement Patterns of Sub-Elite Women Soccer Players during Competitive Matches

Author

Pierre-Hugues Igonin, Isabelle Rogowski, Nathalie Boisseau, Cyril Martin, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Association Sportive de Saint-Etienne (ASSE), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), and Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA)

Subjects
Health, Toxicology and Mutagenesis, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, Football, Athletic Performance, women soccer players, menstrual cycle phase, menstruation, performance, football, Running, Soccer, Humans, Female, human activities, Menstrual Cycle
Abstract

The purpose of this study was to evaluate the influence of the menstrual cycle phases on the movement patterns of sub-elite women soccer players during competitive matches over three consecutive seasons. Individual movement data were analyzed and compared in eight players from the second French League at the early follicular (EF), late follicular (LF) and mid-luteal (ML) phases of their menstrual cycle, determined by the calendar method. The movement patterns, expressed as meters per minute, were recorded during competitive matches using devices placed on the player’s ankle. Our results showed significantly lower distances covered at moderate and high velocity in the EF phase than in the LF and ML phases (Cohen’s d effect size = 1.03 and 0.79, respectively). The total distance covered during matches and the number of sprints also were reduced during EF compared with LF (d = 0.78 and 0.7, respectively). Overall, the total distance and distance covered at low velocity were significantly lower during the second half-time of the matches (d = 1.51), but no menstrual cycle phase × game period interaction was noted. In conclusion, our study suggests that EF may impact the movement pattern of sub-elite women soccer players during competitive matches, without any modulation of this effect by the playing time. Despite the low sample size, these results can be useful for coaches and support staff to modulate training loads and player rotation during soccer games.

Published
2022

45. The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world

Author

Gal Manella, Saar Ezagouri, Benoit Champigneulle, Jonathan Gaucher, Monique Mendelson, Emeline Lemarie, Emeric Stauffer, Aurélien Pichon, Connor A. Howe, Stéphane Doutreleau, Marina Golik, Samuel Verges, Gad Asher, Weizmann Institute of Science [Rehovot, Israël], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Laboratoire 'Mobilité, Vieillissement, Exercice' (MOVE), Université de Poitiers, University of British Columbia (UBC), ANR-12-TECS-0010,PASITHEA,Traitement personnalisé et adaptatif par stimulation kinesthésique pour les syndromes d'apnée du sommeil, basé sur un moniteur Holter cardio-respiratoire(2012), ANR-15-IDEX-0002,UGA,IDEX UGA(2015), ANR-19-CE14-0037,TEMPORISE,Interaction entre l'hypoxie et l'horloge biologique dans le développement de la maladie du foie liée à l'apnée du sommeil(2019), SALAS, Danielle, Technologie pour la santé et l'autonomie - Traitement personnalisé et adaptatif par stimulation kinesthésique pour les syndromes d'apnée du sommeil, basé sur un moniteur Holter cardio-respiratoire - - PASITHEA2012 - ANR-12-TECS-0010 - TecSan - VALID, IDEX UGA - - UGA2015 - ANR-15-IDEX-0002 - IDEX - VALID, and Interaction entre l'hypoxie et l'horloge biologique dans le développement de la maladie du foie liée à l'apnée du sommeil - - TEMPORISE2019 - ANR-19-CE14-0037 - AAPG2019 - VALID

Subjects
lowlanders, [SDV]Life Sciences [q-bio], Altitude, circadian clocks, daily rhythms, CIBERSORTx, General Biochemistry, Genetics and Molecular Biology, immune response, whole-blood transcriptomics, [SDV] Life Sciences [q-bio], high altitude, clock genes, Humans, CP: Molecular biology, Hypoxia, Transcriptome
Abstract

International audience; High altitude exposes humans to hypobaric hypoxia, which induces various physiological and molecular changes. Recent studies point toward interaction between circadian rhythms and the hypoxic response, yet their human relevance is lacking. Here, we examine the effect of different high altitudes in conjunction with time of day on human whole-blood transcriptome upon an expedition to the highest city in the world, La Rinconada, Peru, which is 5,100 m above sea level. We find that high altitude vastly affects the blood transcriptome and, unexpectedly, does not necessarily follow a monotonic response to altitude elevation. Importantly, we observe daily variance in gene expression, especially immune-related genes, which is largely altitude dependent. Moreover, using a digital cytometry approach, we estimate relative changes in abundance of different cell types and find that the response of several immune cell types is time- and altitude dependent. Taken together, our data provide evidence for interaction between the transcriptional response to hypoxia and the time of day in humans.

Published
2022

46. Comparison of skin and shoe marker placement on metatarsophalangeal joint kinematics and kinetics during running

Author

T.P Perrin, C.Y.M Morio, T. Besson, H.A Kerhervé, G.Y Millet, J. Rossi, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Decathlon SportsLab, Pôle de Formation des Professionnels de Santé du Centre hospitalier de Rennes (PFPS), Laboratoire Mouvement Sport Santé (M2S), and Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Markerset, [SDV]Life Sciences [q-bio], Rehabilitation, Biomedical Engineering, Biophysics, Orthopedics and Sports Medicine, Footwear, Motion capture, Metatarsophalangeal joint
Abstract

International audience; This study investigated the effects of marker placement (skin- vs shoe-mounted) on metatarsophalangeal joint (MTP) kinematics and kinetics during running. Fifteen trained men ran on a 15-m track at 10 and 13 km/h with three (low, standard and high stiffness) shoe longitudinal bending stiffnesses (LBS). Reflective markers were fixed on the shoe upper, and on the skin using holes cut in the shoe. Three-dimensional marker positions and ground reaction forces were recorded at 200 and 2000 Hz, respectively. Kinematic and kinetic parameters were analyzed using one-dimensional metrics (statistical parametric mapping). MTP joint was less dorsiflexed at midstance ([57% to 100%] of braking phase and [0% to 48%] of pushing phase), and the MTP joint plantarflexion moment was higher ([22% to 55%] of pushing phase) with the shoe markerset in comparison with the skin markerset. The effect of LBS on MTP angle was found to be significant for a larger percentage of each stride using the shoe markerset compared to the skin markerset. However, the effect of LBS on plantarflexion moment was significant with the shoe markerset only. The effect of running speed on MTP angle was significant for a larger percentage of each stride with the skin markerset. This study demonstrates that the placement of markers influences the measurement of MTP kinematics and kinetics and that these effects are mediated by other variables such as LBS or running speed. It is concluded that the shoe markerset does not fully reflect the movement of the MTP joint.

Published
2022

47. The effects of an ankle destabilization device on muscular activity while walking

Author

Pascal Toschi, Nicolas Forestier, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Adult, Joint Instability, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], medicine.medical_specialty, Heel, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Electromyography, Walking, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Reference Values, Subtalar joint, Peroneus longus, medicine, Humans, Orthopedics and Sports Medicine, [ SDV.OT ] Life Sciences [q-bio]/Other [q-bio.OT], Muscle, Skeletal, ComputingMilieux_MISCELLANEOUS, Rehabilitation, Braces, medicine.diagnostic_test, business.industry, 030229 sport sciences, Equipment Design, Ankle stabilization, medicine.anatomical_structure, Ankle, Peroneus brevis, business, 030217 neurology & neurosurgery, Muscle Contraction
Abstract

Chronic Ankle Instability sprain causes are unclear and many factors or mechanisms may contribute to recurrence of this injury. The aim of the study was to investigate how an ankle destabilization device affects the EMG patterns of the ankle muscles during ankle stabilization against inversion. The left foot was equipped with a mechanical device mounted under the heel of the shoe. This mechanical device induces subtalar joint destabilization necessitating the control of ankle muscles. Surface electrodes were placed over the tibialis anterior, the peroneus longus, the peroneus brevis, the gastrocnemius lateral, and the gastrocnemius medial. Nine healthy subjects (mean age 37+/-12 yr; mean mass 68+/-17 kg; mean height 1.73+/-0.7 m) were instructed to walk normally along a tape fixed on the floor. The ankle destabilization device altered the walking pattern of all subjects. More specifically, the walking pattern is disturbed resulting in higher amplitude of the EMG activity of the peroneal muscles and the Tibialis Anterior and anticipatory reactions in the peroneal muscles. The results suggest that the ankle destabilization device could be beneficial for rehabilitation programs especially during the training of walking. Using this material may help to a specific reinforcement of muscles involved in anti-inversion ankle movement.

Published
2005

48. Point: Counterpoint: Hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia

Author

Raphael Faiss, Grégoire P. Millet, Vincent Pialoux, Institut des Systèmes Intelligents et de Robotique (ISIR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université de Lausanne (UNIL), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Lausanne = University of Lausanne (UNIL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Normobaric hypoxia, medicine.medical_specialty, Physiology, [SDV]Life Sciences [q-bio], Oxygen metabolism, chemistry.chemical_element, 030229 sport sciences, Partial pressure, Hypoxia (medical), Nitric oxide metabolism, Oxygen, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, chemistry, Physiology (medical), Internal medicine, Anesthesia, medicine, Water-Electrolyte Balance, Hypobaric hypoxia, medicine.symptom, ComputingMilieux_MISCELLANEOUS, 030217 neurology & neurosurgery
Abstract

Hypoxia is defined as any combination of reduced barometric pressure (PB) and/or a reduced inspired fraction of oxygen (FiO2), which ultimately results in an inspired partial pressure of oxygen (PiO2) less than 150 mmHg ([6][1]). Pathophysiological responses to hypoxia or adaptations to hypoxic

Published
2012

49. Long-term abdominal wall benefits of the laparoscopic approach in liver left lateral sectionectomy: a multicenter comparative study

Author

Jean-Yves Mabrut, Jean Hardwigsen, Mickael Lesurtel, Olivier Soubrane, François Cauchy, Jean-Marc Regimbeau, Kayvan Mohkam, Stéphanie Truant, Daniel Cherqui, Emmanuel Boleslawksi, Guillaume Millet, Benjamin Darnis, Christophe Laurent, J. Dembinski, Philippe Bachelier, Eric Vibert, Nicolas Golse, Clinique de la Sauvegarde [Lyon], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, SImulations en Médecine, BIOtechnologie et ToXicologie de systèmes multicellulaires (SIMBIOTX ), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre Hépato-Biliaire [Hôpital Paul Brousse] (CHB), Hôpital Paul Brousse-Assistance Publique - Hôpitaux de Paris, Service d’Hépatologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Service de Gastroentérologie [Hôpital Beaujon], Chirurgie digestive [CHU Amiens], CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Service de Chirurgie, Assistance Publique - Hôpitaux de Marseille (APHM)-Hospices Civiles de Marseille-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), CHU Strasbourg, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), CHU Lille, Université de Lille, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Incisional hernia, [SDV]Life Sciences [q-bio], Incidence (epidemiology), Hepatology, medicine.disease, Surgery, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Internal medicine, Medicine, 030211 gastroenterology & hepatology, Hernia, business, Laparoscopy, Complication, Abdominal surgery
Abstract

International audience; Background Laparoscopy is nowadays considered as the standard approach for hepatic left lateral sectionectomy (LLS), but its value in the prevention of incisional hernia (IH) has not been demonstrated. Methods Between 2012 and 2017, patients undergoing laparoscopic (LLLS) or open LLS (OLLS) in 8 centers were compared. Patients undergoing a simultaneous major abdominal procedure were excluded. The incidence of IH was assessed clinically and morphologically on computed tomography (CT) using inverse probability of treatment weighting (IPTW) and multivariable regression analysis. Results After IPTW, 84 LLLS were compared to 48 OLLS. Compared to OLLS, LLLS patients had reduced blood loss (100 [IQR: 50-200] ml vs. 150 [IQR: 50-415] ml,p = 0.023) and shorter median hospital stay (5 [IQR: 4-7] days vs. 7 [6-9] days,p < 0.001), but experienced similar rate of postoperative complications (mean comprehensive complication index: 12 +/- 19 after OLLS versus 13 +/- 20 after LLLS,p = 0.968). Long-term radiological screening was performed with a median follow-up of 27.4 (12.1-44.9) months. There was no difference between the two groups in terms of clinically relevant IH (10.7% [n = 9] after LLLS, 8.3% [n = 4] after OLLS,p = 0.768). The rate of IH detected on computed tomography was lower after LLLS than after OLLS (11.9% [n = 10] versus 29.2% [n = 14],p = 0.013). On multivariable analysis, the laparoscopic approach was the only independent factor influencing the risk of morphological IH (OR = 0.290 [95% CI: 0.094-0.891],p = 0.031). The 2 preferential sites for specimen extraction after LLLS were Pfannenstiel and midline incisions, with rates of IH across the extraction site of 2.3% [n = 1/44] and 23.8% [n = 5/21], respectively (p = 0.011). Conclusion The laparoscopic approach for LLS decreases the risk of long-term IH as evidenced on morphological examinations, with limited clinical impact. Pfannenstiel's incision should be preferred to midline incision for specimen extraction after LLLS.

Published
2020

50. Fatigue and Recovery after Single-Stage versus Multistage Ultramarathon Running

Author

Samuel Verges, Thibault Besson, Thibault Le Roux Mallouf, Jérémy Rossi, Stéphane Doutreleau, Matthieu Marechal, Guillaume Y. Millet, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), and SALAS, Danielle

Subjects
Adult, Male, Competitive Behavior, Nerve stimulation, Time Factors, [SDV]Life Sciences [q-bio], Marathon Running, Physical Therapy, Sports Therapy and Rehabilitation, Plantar flexion, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Knee, Orthopedics and Sports Medicine, Muscle, Skeletal, Knee extensors, Foot, Single stage, business.industry, 030229 sport sciences, Middle Aged, Evoked Potentials, Motor, Biomechanical Phenomena, [SDV] Life Sciences [q-bio], Neuromuscular fatigue, Anesthesia, Muscle Fatigue, Physical Endurance, Female, business, Muscle Contraction
Abstract

International audience; Purpose: Ultramarathon running includes two main types of events: single-stage race (SSR) and multistage races (MSR). Direct comparison of neuromuscular fatigue and recovery after SSR versus MSR race of comparable distance and elevation has never been performed. The aim of this study was to assess neuromuscular fatigue and recovery after two ultramarathons of equal distance performed either (i) in a single stage or (ii) in four successive days.Methods: Thirty-one runners participated in the study: 17 ran 169 km in a single-stage race and 14 performed around 40 km·d over 4 d. The two races were performed on the same course. Neuromuscular function was tested before (PRE), after (POST), and 2 (D + 2), 5 (D + 5) and 10 (D + 10) days after the races. Neuromuscular function was evaluated on both knee extensors (KE) and plantar flexors (PF) with voluntary and evoked contractions using electrical (femoral and tibial, respectively) nerve stimulation.Results: Reduction of voluntary activation measured in the KE was greater (i.e., central fatigue) for SSR than MSR directly after the race (-23% vs -7%), P < 0.01). Reductions in evoked mechanical KE and PF responses on relaxed muscle (i.e., peripheral fatigue) of both KE and PF took longer to recover in MSR than in SSR.Conclusions: Performing prolonged running exercise over several days, each separated by rest, elicits more prolonged impairments in contractile function compared with single-stage ultramarathon, whereas single-stage mountain ultramarathon ran on the same course is associated with greater central fatigue.

Published
2020

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