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Evolution of blood rheology and its relationship to pulmonary hemodynamic during the first days of exposure to moderate altitude
- Source :
- Clinical Hemorheology and Microcirculation, Clinical Hemorheology and Microcirculation, IOS Press, 2019, pp.1-8. ⟨10.3233/CH-190671⟩, Clinical Hemorheology and Microcirculation, 2019, pp.1-8. ⟨10.3233/CH-190671⟩
- Publication Year :
- 2019
-
Abstract
- Blood rheology and hemodynamic parameters have never been explored together during acclimatization to altitude. This study aimed to investigate changes in blood rheology parameters and pulmonary hemodynamics during the first days of real moderate altitude exposure.Seventeen athletes were tested at sea-level, 20 hours after their arrival at 2,400 meters of altitude (H1) and five days later (H2). Blood was sampled to analyze red blood cell (RBC) aggregation, blood viscosity and hematocrit. Pulmonary arterial pressure (PAP), pulmonary capillary pressure (Pcap) and pulmonary vascular resistance (PVR) were assessed by echocardiography.We observed a rise in hematocrit, blood viscosity, RBC aggregation, PAP, Pcap and PVR between sea-level and H1. In H2, RBC aggregation, hematocrit, PAP, Pcap and PVR remained different compared to sea-level and no difference was observed between H1 and H2. Blood viscosity decreased in H2 and returned to sea-level values.Our results suggest that hemoconcentration occurring within the first hours of altitude exposure increased blood viscosity, which contributed to the changes in pulmonary hemodynamic. When blood viscosity decreased in H2, no change occurred in pulmonary hemodynamic parameters suggesting that hypoxic pulmonary vasoconstriction was still present. The elevated RBC aggregation observed after in H2 could participate in the increase of Pcap.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pulmonary Circulation
Physiology
Blood viscosity
Hemodynamics
030204 cardiovascular system & hematology
Hematocrit
Acclimatization
030218 nuclear medicine & medical imaging
03 medical and health sciences
[SCCO]Cognitive science
Young Adult
0302 clinical medicine
Physiology (medical)
Internal medicine
Hypoxic pulmonary vasoconstriction
medicine
Humans
ComputingMilieux_MISCELLANEOUS
medicine.diagnostic_test
business.industry
Altitude
Hematology
Hemoconcentration
Healthy Volunteers
Red blood cell
medicine.anatomical_structure
Vascular resistance
Cardiology
Cardiology and Cardiovascular Medicine
business
Rheology
Subjects
Details
- ISSN :
- 18758622 and 13860291
- Volume :
- 74
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical hemorheology and microcirculation
- Accession number :
- edsair.doi.dedup.....abc7333b654180bb8b434e944d1fe7a6