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Este artículo analiza uno de los episodios más importantes de la batalla ideológica y cultural entre el PSI de Craxi y el PCI de Berlinguer de los años 1976-1978: la crítica socialista del concepto de “Hegemonía” de Antonio Gramsci. Una crítica que se produce en la revista Mondoperaio en 1977 y coincide con el 40 aniversario de la muerte de Gramsci. Como se tratará de mostrar, esta crítica del pensamiento gramsciano está vinculado a los procesos de transformación ideológica del socialismo y el comunismo del sur de Europa a finales de los años setenta. En este sentido, la crítica del concepto de “Hegemonía” de Gramsci que realizarán los intelectuales del PSI, denunciando su matriz leninista, no puede disociarse del debate sobre la legitimidad de los partidos comunistas para gobernar en las democracias occidentales durante la Guerra fría.

Collection of data for Asian American, Native Hawaiian, and Pacific Islander (AANHPI) persons that is disaggregated by ethnic subgroup may identify disparities that are not apparent in aggregated data. Using content analysis, we identified national population surveys administered by the US Department of Health and Human Services (HHS) and evaluated trends in the collection of disaggregated AANHPI data between 2011 and 2021.In 2011, 4 of 15 surveys (27%) collected disaggregated data for Asian American, 2 of 15 surveys (13%) collected data on Native Hawaiian, and 2 of 15 surveys (13%) collected disaggregated data for Pacific Islander people. By 2019, 14 of 21 HHS-administered surveys (67%) collected disaggregated data for Asian American (6 subgroups), 67% collected data on Native Hawaiian, and 67% collected disaggregated data on Pacific Islander (3 subgroups) people.Collection of disaggregated AANHPI data in HHS-administered surveys increased from 2011 to 2021, but opportunities to expand collection and reporting remain. Strategies include outreach with community organizations, increased language assistance, and oversampling approaches. Increased availability and reporting of these data can inform health policies and mitigate disparities. (Am J Public Health. 2022;112(10):1429–1435. https://doi.org/10.2105/AJPH.2022.306969 )

The authors report two cases of unusually large deposits on their therapeutic bandage contact lens (BCL) following uneventful surgery for congenital ptosis. The first case presented at 6 weeks with decreased vision, large jelly-bump deposits over the contact lens and sterile corneal infiltrates. The infiltrates rapidly resolved with restoration of vision following contact lens removal and topical antibiotics. The second case presented 2 weeks after surgery with visual loss and similar deposits but with no corneal involvement. Following replacement of BCL and topical lubricants, her vision improved to 20/20. Studies on the role of BCL in ptosis surgery are scarce with literature supporting its use for ocular surface protection and minimising postoperative discomfort. The authors hypothesise impaired blink mechanism as the accelerating factor for this unusual occurrence in the early postoperative period and recommend frequent replacement of the contact lens and a closer follow-up in all these cases.

The paper is devoted to modern experimental and computational studies analysis on the point of asymmetric destruction of ice on the surfaces of the working blades of gas-turbine engine blades. A schematic diagram of an experimental setup has been developed, which consists of the following main elements: a wind tunnel, a cold chamber, a model fan, an electric motor, and a high-speed video camera. The experimental setup makes it possible to carry out laboratory studies of the ice formation and destruction processes. The choice of the experimental test rig parameters was made to allow assessing the icing of the blades of a rotating fan, which reproduces the processes occurring on gas turbine engines. Based on the results of three-dimensional gas-dynamic and strength calculations, the design and basic geometrical parameters of the flow path and the dummy fan were determined. The dependences of compression ratio Pk and the power consumption of a model fan Wcons on the value of the mass air flow Gair for a different number of rotor blades are presented. The choice of materials for the disk hub and blades of a dummy fan which experience tensile and bending loads at high rotation speeds up to 12.000 rpm was made, that satisfies the conditions of static and dynamic strength, also the allowable safety factors were evaluated, and pressure characteristics were obtained.

The breast cancer hold leading position in the structure of oncological morbidity of women worldwide. The purpose of the study is to analyze contribution of psychological and environmental factors to risk of development of breast cancer in women residing in industrial metropolis and rural locality. The actuality of the study is conditioned by acquisition of new knowledge about risk factors of breast cancer. The study covered psychological factors (basic beliefs, life orientations, locus of control, coping behavior strategies, subjective assessment of quality of life, subjective age indicator, personal helplessness-independence, resilience) and environmental factor (place of urban of rural residence of women with breast cancer). The study established that in women residing in industrial metropolis the psychological risk factors are reduced indicators of basic beliefs, of quality of life and of resilience, rare application of coping strategy “Escape-Avoidance”, external locus of control. Alternatively, in women residing in rural areas, psychological risk factors for breast cancer are rare application of coping strategies, reduced quality of life indicators, increased vital activity, internal level of subjective control and personal helplessness. The study results can be included in development of personalized breast cancer screening protocols and as well as considered in assessing risk of development of disease when classifying women by breast cancer risk groups.

INTRODUCTION: In the 330-patient ADVOCATE trial of avacopan for the treatment of antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, in which 81% of patients had renal involvement, estimated glomerular filtration rate (eGFR) increased on average 7.3 ml/min per 1.73 m(2) in the avacopan group and 4.1 ml/min per 1.73 m(2) in the prednisone group (P = 0.029) at week 52. This new analysis examines the results in the patient subgroup with severe renal insufficiency at enrollment into the trial, i.e., eGFR ≤20 ml/min per 1.73 m(2). METHODS: eGFR was determined at baseline and over the course of the trial. Changes in eGFR were compared between the 2 treatment groups. RESULTS: In ADVOCATE, 27 of 166 patients (16%) in the avacopan group and 23 of 164 patients (14%) in the prednisone group had a baseline eGFR ≤20 ml/min per 1.73 m(2). At week 52, eGFR increased on average 16.1 and 7.7 ml/min per 1.73 m(2) in the avacopan and prednisone groups, respectively (P = 0.003). The last eGFR value measured during the 52-week treatment period was ≥2-fold higher than baseline in 41% of patients in the avacopan group compared to 13% in the prednisone group (P = 0.030). More patients in the avacopan group versus prednisone group had increases in eGFR above 20, 30, and 45 ml/min per 1.73 m(2), respectively. Serious adverse events occurred in 13 of 27 patients (48%) in the avacopan group and 16 of 23 patients (70%) in the prednisone group. CONCLUSION: Among patients with baseline eGFR ≤20 ml/min per 1.73 m(2) in the ADVOCATE trial, eGFR improved more in the avacopan group than in the prednisone group.

The European Space Agency is studying two large-class missions bound to operate in the decade of the 30s, and aiming at investigating the most energetic and violent phenomena in the Universe. $Athena$ is poised to study the physical conditions of baryons locked in large-scale structures from the epoch of their formation, as well as to yield an accurate census of accreting super-massive black holes down to the epoch of reionization; LISA will extend the hunt for Gravitational Wave (GW) events to the hitherto unexplored mHz regime. We discuss in this paper the science that their concurrent operation could yield, and present possible $Athena$ observational strategies. We focus on Super-Massive (M$\lesssim10^7\rm M_{\odot}$) Black Hole Mergers (SMBHMs), potentially accessible to $Athena$ up to $z\sim2$. The simultaneous measurement of their electro-magnetic (EM) and GW signals may enable unique experiments in the domains of astrophysics, fundamental physics, and cosmography, such as the magneto-hydrodynamics of fluid flows in a rapidly variable space-time, the formation of coronae and jets in Active Galactic Nuclei, and the measurement of the speed of GW, among others. Key to achieve these breakthrough results will be the LISA capability of locating a SMBHM event with an error box comparable to, or better than the field-of-view of the $Athena$ Wide Field Imager ($\simeq0.4\,$deg$^2$) and $Athena$ capability to slew fast to detect the source during the inspiral phase and the post-merger phase. Together, the two observatories will open in principle the exciting possibility of truly concurrent EM and GW studies of the SMBHMs, Comment: 17 pages, 8 figures. Accepted for publication in MNRAS

BACKGROUND: Enrichment strategies from clinical trials for progressive systemic sclerosis-associated interstitial lung disease (SSc-ILD) have not been tested in a real-life cohort.RESEARCH QUESTION: Do enrichment strategies for progressive ILD impact efficacy, repre-sentativeness, and feasibility in patients with SSc-ILD from the European Scleroderma Trials and Research (EUSTAR) database?STUDY DESIGN AND METHODS: We applied the inclusion criteria of major recent SSc-ILD trials (Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis [focuSSced], Scleroderma Lung Study II [SLS II], and Safety and Efficacy of Nintedanib in Systemic Sclerosis [SENSCIS]) and assessed progressive ILD, which was defined as absolute change in FVC and as significant progression (FVC decline $10%). Data were compared with all patients and with patients who did not fulfill any inclusion criteria. RESULTS: In total, 2,258 patients with SSc-ILD were included: 31.2% of the patients met SENSCIS criteria; 5.8% of the patients met SLS II criteria; 1.6% of the patients met focuSSced criteria, and 67.7% (1,529) of the patients did not meet any criteria. In the first 12 + 3 months, the absolute FVC decline in all patients and in patients who fulfilled criteria from SENSCIS was -0.1%, in patients who fulfilled criteria from focuSSced was -3.7%, and in patients who fulfilled criteria from SLS II was 2.3%, with accompanying more progressors in focuSSced. The patient populations that fulfilled the different study inclusion criteria significantly differed in various clinical parameters. In the second 12-month period, SENSCIS-enriched patients had a further absolute FVC% decline as described for the total cohort. In contrast, patients who fulfilled the focuSSced and SLS II criteria showed numeric improvement of lung function. There were no significant associations of enrichment criteria and ILD progression.INTERPRETATION: The application of enrichment criteria from previous clinical trials showed enrichment for progression with variable success, which led to selected patient populations reducing feasibility of recruitment. These findings are important for future clinical trial design and interpretation of the results of published trials.CHEST 2023; 163(3):586-598

An overview of the recent operations and the main results of cesium injection in the Source for the Production of Ions of Deuterium Extracted from Rf plasma (SPIDER) negative ion source are described in this contribution. In experiments without cesium injection, all SPIDER plants were tested to verify the basic expectations on the operational parameters (e.g., electron cooling effectiveness of magnetic filter field) and to determine its operational region. For beam properties, it was shown that the current density varies across the beam in the vertical direction. In preliminary cesium experiments, the expected increase of negative ion current and simultaneous decrease of co-extracted electrons were found, along with the influence of the control parameters (polarization of the plasma electrodes, magnetic filter field) on the SPIDER beam uniformity in the horizontal and vertical directions. It was shown that non-Gaussian tails can be identified in the angular distribution on the plane perpendicular to the beam propagation direction. Stray particles, nonhomogeneous beam and large divergence might result in unexpected heat and particle loads over ITER neutral beam injector (NBI) accelerator grids; it is the goal of SPIDER to assess and possibly to identify suitable methods for controlling these beam features. A major shutdown, planned for late 2021, to solve the issues identified during the operation and to carry out scheduled modifications, is outlined. Such improvements are expected to allow SPIDER to pursue the ITER requirements in terms of negative ion current, electron-to-ion ratio, and beam duration.

Transmission spectroscopy of exoplanets has revealed signatures of water vapor, aerosols, and alkali metals in a few dozen exoplanet atmospheres. However, these previous inferences with the Hubble and Spitzer Space Telescopes were hindered by the observations' relatively narrow wavelength range and spectral resolving power, which precluded the unambiguous identification of other chemical species$-$in particular the primary carbon-bearing molecules. Here we report a broad-wavelength 0.5-5.5 $\mu$m atmospheric transmission spectrum of WASP-39 b, a 1200 K, roughly Saturn-mass, Jupiter-radius exoplanet, measured with JWST NIRSpec's PRISM mode as part of the JWST Transiting Exoplanet Community Early Release Science Team program. We robustly detect multiple chemical species at high significance, including Na (19$\sigma$), H$_2$O (33$\sigma$), CO$_2$ (28$\sigma$), and CO (7$\sigma$). The non-detection of CH$_4$, combined with a strong CO$_2$ feature, favours atmospheric models with a super-solar atmospheric metallicity. An unanticipated absorption feature at 4$\mu$m is best explained by SO$_2$ (2.7$\sigma$), which could be a tracer of atmospheric photochemistry. These observations demonstrate JWST's sensitivity to a rich diversity of exoplanet compositions and chemical processes., Comment: 41 pages, 4 main figures, 10 extended data figures, 4 tables. Under review in Nature

We use the surface detector of the Pierre Auger Observatory to search for air showers initiated by photons with an energy above 1019 eV. Photons in the zenith angle range from 30∘ to 60∘ can be identified in the overwhelming background of showers initiated by charged cosmic rays through the broader time structure of the signals induced in the water-Cherenkov detectors of the array and the steeper lateral distribution of shower particles reaching ground. Applying the search method to data collected between January 2004 and June 2020, upper limits at 95% CL are set to an E-2 diffuse flux of ultra-high energy photons above 1019 eV, 2 × 1019 eV and 4 × 1019 eV amounting to 2.11 × 10-3, 3.12 × 10-4 and 1.72 × 10-4 km-2 sr-1 yr-1, respectively. While the sensitivity of the present search around 2 × 1019 eV approaches expectations of cosmogenic photon fluxes in the case of a pure-proton composition, it is one order of magnitude above those from more realistic mixed-composition models. The inferred limits have also implications for the search of super-heavy dark matter that are discussed and illustrated.

Abstract: For the treatment of brain illnesses, there is growing interest in nose-to-brain drug administration. Other, more traditional methods of crossing the blood–brain barrier (BBB) is ineffective. As a result, the therapeutic concentration in the brain cannot be achieved, and the reaction is inadequate. One intriguing technique for avoiding first-pass metabolism and bypassing the blood-brain barrier is intranasal medication delivery. It lowers medicine doses while reducing systemic side effects. When compared to conventional drug delivery platforms, a nanoparticulate drug delivery method allows for greater penetration via the nasal route. It is better to make the nanoparticles for nose-to-brain administration when a good carrier (polymers) is used. This review focuses on the many processes for creating polymeric nanoparticles, strategies and tactics for improving nose-to-brain drug delivery efficiency, and nanoparticle characterization. The use of the nose-to-brain drug delivery platform is being explored using a variety of nanoparticles created by researchers for the treatment of brain illnesses.

The coastal landscape of the Kachchh Upland (KU) region (NW-India) changed over the last few thousand years from a shallow marine gulf to a salty desert (1-4 meters asl). In this area, bordered to the south by the Northern Hill Range (NHR), the tectonic-climatic interaction triggered the sea level fall from +2/4 m circa (6000-2000 BP) to zero. An ancient river pattern deposited a tidally regulated delta area during the sea level fall that stopped 2000-3000 years ago due to tectonic activity and a dry climate. Deltaic-alluvial fans (DAF) in front of the NHR suggest that the KU's tectonic activity led to fast landscape evolution. We explored such drastic changes by integrating scientific information from a multidisciplinary literature review, identifying terraces and DAFs, and inferring faults through landform recognition, quantitative morphometry, and field surveys. Our interpretation, summarized in a map, provides new information on active processes along the NHR.

This conceptual design report provides a detailed account of the European Spallation Source neutrino Super Beam (ESS$\nu$SB) feasibility study. This facility has been proposed after the measurements reported in 2012 of a relatively large value of the neutrino mixing angle $\theta_{13}$, which raised the possibility of observing potential CP violation in the leptonic sector with conventional neutrino beams. The measured value of $\theta_{13}$ also privileges the $2^{nd}$ oscillation maximum for the discovery of CP violation instead of the more typically studied $1^{st}$ maximum. The sensitivity at this $2^{nd}$ oscillation maximum is about three times higher than at the $1^{st}$ one, which implies a reduced influence of systematic errors. Working at the $2^{nd}$ oscillation maximum requires a very intense neutrino beam with an appropriate energy. The world's most intense pulsed spallation neutron source, the European Spallation Source (ESS), will have a proton linac operating at 5\,MW power, 2\,GeV kinetic energy and 14~Hz repetition rate (3~ms pulse duration, 4\% duty cycle) for neutron production. In this design study it is proposed to double the repetition rate and compress the beam pulses to the level of microseconds in order to provide an additional 5~MW proton beam for neutrino production. The physics performance has been evaluated for such a neutrino super beam, in conjunction with a megaton-scale underground water Cherenkov neutrino detector installed at a distance of 360--550\,km from ESS. The ESS proton linac upgrades, the accumulator ring required for proton-pulse compression, the target station design and optimisation, the near and far detector complexes, and the physics potential of the facility are all described in this report. The ESS linac will be operational by 2025, at which point the implementation of upgrades for the neutrino facility could begin., Comment: 216 pages

We use the small scales of the Dark Energy Survey (DES) Year-3 cosmic shear measurements, which are excluded from the DES Year-3 cosmological analysis, to constrain the baryonic feedback. To model the baryonic feedback, we adopt a baryonic correction model and use the numerical package \texttt{Baccoemu} to accelerate the evaluation of the baryonic nonlinear matter power spectrum. We design our analysis pipeline to focus on the constraints of the baryonic suppression effects, utilizing the implication given by a principal component analysis on the Fisher forecasts. Our constraint on the baryonic effects can then be used to better model and ameliorate the effects of baryons in producing cosmological constraints from the next generation large-scale structure surveys. We detect the baryonic suppression on the cosmic shear measurements with a $\sim 2 \sigma$ significance. The characteristic halo mass for which half of the gas is ejected by baryonic feedback is constrained to be $M_c > 10^{13.2} h^{-1} M_{\odot}$ (95\% C.L.). The best-fit baryonic suppression is $\sim 5\%$ at $k=1.0 {\rm Mpc}\ h^{-1}$ and $\sim 15\%$ at $k=5.0 {\rm Mpc} \ h^{-1}$. Our findings are robust with respect to the assumptions about the cosmological parameters, specifics of the baryonic model, and intrinsic alignments., Comment: 20 pages, 10 figures. DES Collaboration, Year-3 analysis

There is a growing body of work suggesting that social class stereotypes are amplified when people perceive higher levels of economic inequality—that is, the wealthy are perceived as more competent and assertive and the poor as more incompetent and unassertive. The present study tested this prediction in 32 societies and also examines the role of wealth-based categorization in explaining this relationship. We found that people who perceived higher economic inequality were indeed more likely to consider wealth as a meaningful basis for categorization. Unexpectedly, however, higher levels of perceived inequality were associated with perceiving the wealthy as less competent and assertive and the poor as more competent and assertive. Unpacking this further, exploratory analyses showed that the observed tendency to stereotype the wealthy negatively only emerged in societies with lower social mobility and democracy and higher corruption. This points to the importance of understanding how socio-structural features that co-occur with economic inequality may shape perceptions of the wealthy and the poor. © 2022 The Authors. European Journal of Social Psychology published by John Wiley & Sons Ltd. WOS:000880016700001 2-s2.0-85141616689 Social Sciences Citation Index Q2 Article Uluslararası işbirliği ile yapılan - EVET 2022 YÖK - 2022-23 Kasım

M. Dixon et al., We use stacked spectra of the host galaxies of photometrically identified Type Ia supernovae (SNe Ia) from the Dark Energy Survey (DES) to search for correlations between Hubble diagram residuals and the spectral properties of the host galaxies. Utilizing full spectrum fitting techniques on stacked spectra binned by Hubble residual, we find no evidence for trends between Hubble residuals and properties of the host galaxies that rely on spectral absorption features (, MD would like to acknowledge support through an Australian Government Research Training Program Scholarship. This research was supported by the Australian Research Council The Centre of Excellence for Dark Matter Particle Physics (CDM; project number CE200100008) and the Australian Research Council Centre of Excellence for Gravitational Wave Discovery (OzGrav; project number CE170100004). This project/publication was made possible through the support of a grant from the John Templeton Foundation. The authors gratefully acknowledge this grant ID 61807, Two Standard Models Meet. The opinions expressed in this publication are those of the author(s) and do not necessarily reflect the views of the John Templeton Foundation. Funding for the DES Projects has been provided by the U.S. Department of Energy, the U.S. National Science Foundation, the Ministry of Science and Education of Spain, the Science and Technology Facilities Council of the United Kingdom, the Higher Education Funding Council for England, the National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign, the Kavli Institute of Cosmological Physics at the University of Chicago, the Center for Cosmology and Astro-Particle Physics at the Ohio State University, the Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University, Financiadora de Estudos e Projetos, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico and the Ministério da Ciência, Tecnologia e Inovação, the Deutsche Forschungsgemeinschaft, and the Collaborating Institutions in the Dark Energy Survey. The Collaborating Institutions are Argonne National Laboratory, the University of California at Santa Cruz, the University of Cambridge, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas-Madrid, the University of Chicago, University College London, the DES-Brazil Consortium, the University of Edinburgh, the Eidgenössische Technische Hochschule (ETH) Zürich, Fermi National Accelerator Laboratory, the University of Illinois at Urbana-Champaign, the Institut de Ciències de l’Espai (IEEC/CSIC), the Institut de Física d’Altes Energies, Lawrence Berkeley National Laboratory, the Ludwig-Maximilians Universität München and the associated Excellence Cluster Universe, the University of Michigan, NSF’s NOIRLab, the University of Nottingham, The Ohio State University, the University of Pennsylvania, the University of Portsmouth, SLAC National Accelerator Laboratory, Stanford University, the University of Sussex, Texas A&M University, and the OzDES Membership Consortium. Based in part on observations at Cerro Tololo Inter-American Observatory at NSF’s NOIRLab (NOIRLab Prop. ID 2012B-0001; PI: J. Frieman), which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. The DES data management system is supported by the National Science Foundation under Grant Numbers AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MICINN under grants ESP2017-89838, PGC2018-094773, PGC2018-102021, SEV-2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) including ERC grant agreements 240672, 291329, and 306478. We acknowledge support from the Brazilian Instituto Nacional de Ciência e Tecnologia (INCT) do e-Universo (CNPq grant 465376/2014-2). This manuscript has been authored by Fermi Research Alliance, LLC under Contract No. DE-AC02-07CH11359 with the U.S. Department of Energy, Office of Science, Office of High Energy Physics. Based on data acquired at the Anglo-Australian Telescope, under program A/2013B/012. We acknowledge the traditional custodians of the land on which the AAT stands, the Gamilaraay people, and pay our respects to elders past and present.

The Observing Air–Sea Interactions Strategy (OASIS) is a new United Nations Decade of Ocean Science for Sustainable Development programme working to develop a practical, integrated approach for observing air–sea interactions globally for improved Earth system (including ecosystem) forecasts, CO2 uptake assessments called for by the Paris Agreement, and invaluable surface ocean information for decision makers. Our “Theory of Change” relies upon leveraged multi-disciplinary activities, partnerships, and capacity strengthening. Recommendations from >40 OceanObs’19 community papers and a series of workshops have been consolidated into three interlinked Grand Ideas for creating #1: a globally distributed network of mobile air–sea observing platforms built around an expanded array of long-term time-series stations; #2: a satellite network, with high spatial and temporal resolution, optimized for measuring air–sea fluxes; and #3: improved representation of air–sea coupling in a hierarchy of Earth system models. OASIS activities are organized across five Theme Teams: (1) Observing Network Design & Model Improvement; (2) Partnership & Capacity Strengthening; (3) UN Decade OASIS Actions; (4) Best Practices & Interoperability Experiments; and (5) Findable–Accessible–Interoperable–Reusable (FAIR) models, data, and OASIS products. Stakeholders, including researchers, are actively recruited to participate in Theme Teams to help promote a predicted, safe, clean, healthy, resilient, and productive ocean.

The cause-specific hazard function plays an important role in developing the regression models for competing risks survival data. Proportional hazards and additive hazards are the commonly used regression approaches in survival analysis. Mostly, in literature, the proportional hazards model was used for parametric regression modelling of survival data. In this article, we introduce a parametric additive hazards regression model for survival analysis with competing risks. For employing a parametric model we consider the modified Weibull distribution as a baseline model which is capable to model survival data with non-monotonic behaviour of hazard rate. The estimation process is carried out via maximum likelihood and Bayesian approaches. In addition to Bayesian methods, a class of non-informative types of prior is introduced with squared error (symmetric) and linear-exponential (asymmetric) loss functions. The relative performance of the different estimators is assessed using Monte Carlo simulation. Finally, using the proposed methodology, a real data analysis is performed.

No abstract available

The purpose of this study is to develop the Conflict Areas Index (CAI) to identify possible conflict areas that couples experience in their marriages and to develop the Conflict Styles Inventory (CSI) to assess how they deal with these conflicts. Exploratory (N=374) and confirmatory (N=152) factor analysis and test-retest (N=49) examinations were conducted with a sample of 575 married individuals in total. For the first scale, principal component analysis (PCA) was used to examine the construct validity of the CAI. According to the results, a single component giving frequency values for 15 different conflict areas was identified. In the criterion-related validity studies, the scale had a significant, negative, and strong correlation with the Relationship Assessment Scale (RAS) (r=-.72) and the level of satisfaction with the relationship (r=-.67). The Cronbach's alpha coefficient was found as .91. For the second scale, the construct validity of the CSI was examined using Exploratory Factor Analysis. The results revealed a three-dimensional structure named destructive, passive, and active conflict resolution styles. In the criterion-related validity studies, it was found significant and positive correlations between destructive (r=.14) and passive (r=.18) conflict resolution styles with CAI scores and a significant and negative correlation between active resolution style with CAI scores. In addition, there were significant and negative correlations between destructive (r=-.15) and passive (r=-.12) conflict resolution styles with the RAS scores and a significant and positive correlation between active conflict resolution style with the RAS scores. The Cronbach's alpha coefficients were .88, .87, and .87 for destructive, passive, and active conflict resolution styles, respectively. The correlation values between the scores of the CSI within a 14-day time interval were ⍴=.94, ⍴=.91, and ⍴=.83 for destructive, passive, and active conflict resolution styles, respectively. These results indicated that CAI and CSI have sufficient psychometric properties that can be used to assess conflict areas and conflict resolution styles of married individuals.

Global technological transformations of key areas of life of contemporary society, the formation and active functioning of global and national digital institutions that influence current socio-political processes, and the digitalization of social relations form a demand for comprehensive scientific research on the processes of digital influence on the development and functioning of modern social systems. This article is aimed at considering the problem of the relationship between digital and worldview aspects of the functioning of modern societies. In connection with this, the research issue was to determine the degree and nature of the influence of digitalization processes, as well as directly the digital environment and institutions on the content aspects of the individual’s worldview. This research question is directly related to the study of the phenomenon of public consent in the context of the formation of digital polymentality. To answer the research question posed in the paper, the authors conducted a discourse analysis of the existing scientific literature on the relationship between digitalization and worldview in the pro et contra logic. An international expert study was also conducted, which made it possible to identify the main expert positions on the study, as well as the key risks, threats, and challenges in the field of preserving the traditional worldview and achieving public consent based on the unity of value-semantic and worldview ideas of individuals. The main conclusion of the paper is the fundamental ambiguity of the positions of scientists and experts, justified by the results of the study, in assessing the degree and nature of the influence of digitalization, the digital environment and institutions on the content parameters of the worldview of a modern person, as well as the ambiguity of the value-semantic attitudes formed and maintained in the digital environment.

Corporate Social Responsibility (CSR) has become a decisive reputation tool for companies and as such, a key concept in corporate communication as a phenomenon of intercultural and global significance. This has warranted a comprehensive examination of the language of CSR reports reflecting the principles of the corporate culture. Studies exploring the narratives of CSR reporting currently lack insights into the distribution of meaningful priorities evidenced in language use. This study sets out to explore the linguistic environment of the most frequently occurring language tokens to identify recurrent language patterns used to ensure efficient CSR reporting, and to further establish priority directions in CSR narrative composition evidenced in language use. A corpus-based approach and contextual analysis were adopted to examine CSR reports issued by Microsoft over the last seven years and recognised as an example of best practices in the corporate field. The corpus was compiled using the Prime Machine corpus concordancer tool and comprised 99,176 tokens. Following the study results, the study makes a number of inferences regarding the use of pronouns, “Microsoft + a verb denoting positive action”, “more + than,” “more + adjective”, “Corporate” as part of compound terminological units, as well as a set of key tokens encountered within a descriptive linguistic environment with positive connotation. This, in turn, proved helpful in identifying the hierarchy of priorities distribution revealed in the course of material analysis. The results contribute to a systemic appreciation of corporate language policies facilitating efficient stakeholder communication and can be used in further research investigating related matters of scientific interest.

The review considers the book “The Soviet health care at international arena in 1920-1940: between “soft force” and propaganda (the Western Europe and the USA)” by Ratmanov P. E. The author, on the basis of rich range of historical sources for the first time introduced into scientific turnover, minutely examines phenomenon of the presentation of “The Semashko model” in the international arena. The main array of events described in the book is chronologically divided by two periods - the 1920s and the 1930s. Each of these periods is characterized not only by various forms of presentation of the Soviet health care, but also by directions of cooperation with partner countries. The monograph demonstrably shows that effectiveness of the Soviet medical propaganda was affected by composition of the audience, place and time. Besides, interest in the West to the Soviet model in many ways depended on personal sympathy and political beliefs of representatives of medical community. The author of the book considers the promotion of samples of the Soviet model of medicine as “trade of the future”, i.e. demonstration of common values of the ideology of the Soviet health care, its local successes and promises of major achievements in the future. The monograph is to be recognized as an important step in the study both of the history of scientific medical diplomacy and the role of science in cultural agenda of the Soviet state.

In Russia, the orphan diseases for many years are the object of intent attention both of the national legislation and health care system. The lower prevalence of these diseases in population causes predicaments to timely diagnosis, drug provision and medical care. Besides, absence of integrated approach to issues of diagnosis and treatment of rare diseases contribute nothing to fast solving of actual problems in this field. Frequently, impossibility to get necessary course of treatment forces patients with orphan diseases to seek for alternative sources. The article assesses current situation with medications support of patients suffering from diseases included in the list of life-threatening and chronic progressive rare (orphan) diseases that result in shortening life-span or disability and diseases included in the Federal Program “The 14 high-cost nosologies”. The issues of keeping record of patients and financing medications purchase are touched upon. The study results identified problems of organization of medication support of patients with orphan diseases associated with complexity of accounting their number and absence of integral system of preferential medication support.

The article (the third one of authors cycle of historical studies of medication supply and pharmaceutical business) examines period of economic renaissance of the Russian pharmaceutical market in the first years of third millennium. The state of market according data of Russian analytical agencies, medical periodicals and recollections of participants is considered. The article consists of three reports. In the first report the issue was the “field players” of pharmaceutical market, and in the second one - all the personnel serving market game, making it possible, their reflections on their new, post-Soviet experience of life in private business.

Composite materials reinforced with synthetic fibres have been used in aviation and space technology for more than half a century. Fibre-reinforced composites with high specific strength and corrosion resistance are an attractive alternative to traditional structural materials, including steels, aluminium and titanium alloys. At the same time, composites based on carbon and glass fibres are inherently brittle structural materials with high strength sensitivity to stress concentrations due to the design features of the structures or defects that occur in operation. One way to solve this problem is hybridisation which makes it possible to increase the nonlinearity of the composite stress-strain diagram and reduce sensitivity to notches. Hybrid composites combine several types of reinforcing filler with different fracture strains and exhibit a pronounced pseudo-ductile plateau in tension. Such material behaviour ensures the redistribution of stresses near the concentrator and potentially reduce notch sensitivity. When designing hybrids, it is necessary to take into account the influence of different factors including the ratio between the components and their lay-up, using various technological methods, and the specific strength of the finished material. This paper presents the results of an experimental study on the strength of hybrid composites based on glass and carbon fabrics in the open hole tests. It was found that hybrids with an extended hardening area after the pseudo-yield plateau are were more notch sensitive. A low elongation component layers rotation on angles up to 10°, as well as the use of thin polymer veils, also reduce the sensitivity of the composite strength to the presence of the defects.

The paper deals with the identification of a crack-like defect in a coated wedge based on ultrasonic nondestructive testing. The authors propose an approach of defect identification followed by determination of its geometrical parameters. The approach is based on a shadowed ultrasonic nondestructive testing method combined with deep machine learning technologies. A wedge-shaped area is inspected for the presence of an internal defect. On one edge of the wedge there is a source of ultrasonic vibrations, on the opposite edge there is a receiver. Passing through the coating and body of the wedge, part of the signal is reflected from inhomogeneities and defects that may be present in it. The signal reaching the opposite edge of the wedge is read by the receiver. The received data is processed by a neural network model, which predicts the presence or absence of an internal defect and, if present, determines geometric parameters such as size and position. A finite element model of ultrasonic wave propagation inside the wedge is constructed. Special damping layers are used, due to which the influence of parasitic signal reflections and its further propagation into the wedge body is significantly reduced. Based on the built model, the shadow method of ultrasonic scanning is implemented. This method implies that on one side of the wedge are installed excitation devices, and on the opposite side – receiving devices. Several numerical experiments for various combinations of geometric parameters of the wedge and the defect have been performed using a distributed computing system. Based on the obtained data, a neural network model was built and trained, capable of identifying the defect and determining its characteristics. The input of the model is spectrograms of the readout signal, and the output is values characterizing the defect.

The article presents the results of analysis of issue of disability because of ovarian cancer in female population of the Chechen Republic. The object of study was total number of women, for the first time and repeatedly recognized as disabled ones. The analysis was applied to three age groups (the young, the middle aged and the elderly) in 2014-2020. It is established that dynamics of disability was characterized by negative trends of increasing of number of the disabled. The clear-cut age differentiation was revealed:the elderly disabled predominated. The study established that the disabled suffer of persistent malfunction of blood circulation system and of immune system that resulted in such life activity limitations as moving, self-service and work functions. The characteristics of structure of ovarian cancer disability according its severity were established. The disabled with second group of disability prevailed in all age groups. At that, percentage of women with first group of disability was higher in the middle-aged disabled. The results of the study testify actuality of optimization of onco-gynecological screening of female population for the purpose of early detection of risk factors and diagnosis of malignant process at initial stages of development. This is rational way to organ-preserving treatment and medical and social prevention of primary ovarian cancer disability. The results of the study can consider as scientific practical base for both targeted routing of preventive and therapeutic and rehabilitation measures.

The strength of a square plate with a central crack at normal separation was studied within the framework of the Neuber–Novozhilov approach using a modified Leonov–Panasyuk–Dugdale model using an additional parameter, the diameter of the plasticity zone (width of the pre-fracture zone). As a model of a deformable solid body, a model of an ideal elastic-plastic material with a limiting relative elongation was chosen. This class of materials includes, for example, low-alloy steels used in structures operating at temperatures below the cold brittleness threshold. In the presence of a singular feature in the stress field in the vicinity of the crack tip, it is proposed to use a two-parameter discrete integral strength criterion. The deformation fracture criterion is formulated at the tip of a real crack, and the force criterion for normal stresses, taking into account averaging, is formulated at the tip of a model crack. The lengths of real and model cracks differ by the length of the pre-fracture zone. The constitutive equations of the analytical model are analyzed in detail depending on the characteristic linear dimension of the material structure. Simple formulas suitable for verification calculations for the critical breaking load and the length of the pre-fracture zone are obtained. Numerical modeling of the propagation of plasticity zones in square plates under quasi-static loading has been performed. In the numerical model, the updated Lagrangian formulation of the equations of mechanics of a deformable solid body is used, which is most preferable for modeling the deformation of bodies made of an elastic-plastic material at large deformation. The plastic zone in the vicinity of the crack tip is obtained by the finite element method. The results of analytical and numerical prediction of plate fracture under plane deformation are compared. It is shown that the results of numerical experiments are in good agreement with the results of calculations using the analytical model of fracture of materials with a structure under normal separation. Diagrams of quasi-brittle and quasi-ductile fracture of a structured plate are constructed.

The article is devoted to solving the urgent problem of improving the method of nondestructive testing of the condition of non-rigid road clothes. In addition to the previously developed approach to determining the mechanical parameters of materials of structural layers of nonrigid road coverings based on solving the inverse coefficient problem of restoring operational elastic modules providing specified displacement fields, an approach was developed that allows determining the parameters of energy dissipation in the structure of multilayer road pavement based on the correction of dynamic hysteresis loops recorded in the field and calculated using mathematical model of dynamic VAT. The article presents the results of numerical simulation of dynamic hysteresis loops for two different variants of multilayer structures. The possibilities of correcting the shape of hysteresis loops and their area by varying the tangents of the energy loss angles in layers of a multilayer medium and the elastic modulus of a homogeneous half-space are shown. The complex correction of the elastic modulus values of the structural layers of road clothes and the calculated loops of dynamic hysteresis made it possible to fully take into account the processes of energy attenuation at a distance from the point of application of the load. During the correction, it was found that the values of the elastic modulus of the road layers and the tangents of the loss angles in them have a complex effect on the areas of dynamic hysteresis loops and the nature of energy attenuation at a distance from the point of application of the load. At the same time, the elastic modulus of the underlying half-space is not limited in thickness to the greatest extent on the area of dynamic hysteresis loops (which led to an increase in the elastic modulus of the underlying half-space from 120 and 150 MPa for road construction variants with a reinforced and non-reinforced base to 170 and 160 MPa, respectively), and a decrease in the dissipated energy at a distance from the point of application This is primarily due to the tangent of the angle of energy loss in the half-space. The obtained values of the tangents of the loss angles are obviously related to the patterns of energy dissipation at the boundaries of the contacting layers of the pavement, and also take into account all possible anomalies and delaminations in the calculated structures. Within the framework of this article, calculated hysteresis loops on the surface of the pavement were obtained for the first time, the deformation energy was calculated based on their areas, and the possibility of their comparison with those registered experimentally was proved.

The first ten years of the reign of Tsar Alexei Mikhailovich were distinguished by extreme turbulence. The unsuccessful actions of the “government” of the boyar Morozov provoked chain of city riots which reached their apogee in famous “Salt Riot” in the capital. After that, religious feuding began that in near future resulted in the Schism. Afterwards, Russia, after long hesitation, entered the war with the Polish-Lithuanian Commonwealth that as it turned out, prolonged 13 years. Finally, in 1654, after long break, the plague again visited Russia. The plague pestilence of 1654-1655 was relatively transient (it began in summer and gradually faded away with the onset of winter), however very deadly and shook both the Russian state and Russian society to the ground. It disrupted habitual regular way of life and unsettled all and everything. The authors propose original version of origin of this epidemic and reconstruct its course and consequences on the basis of evidence of contemporaries and extant documents.

To select rational parameters of the process of hybrid additive manufacturing of structures made of structural metal alloys and stainless steels, mechanical characteristics capable of serving as indicators of material quality were determined. The most advanced technologies of additive manufacturing by wire-arc surfacing (plasma, plasma arc with a melting electrode, including cold metal transfer) with layer-by-layer forging with a pneumatic impact tool and subsequent heat treatment were used. Aluminum-magnesium alloy AlMg5, titanium alloy Ti-6Al-4V, austenitic stainless steels 12Cr18Ni10Ti (AISI 321) and AISI 308LSi have been studied. Samples were cut from the blanks created by additive manufacturing – blades for standard tests for static uniaxial tension and cylinders for high-speed compression tests by the Kolsky method on a Hopkinson split bar. According to the registered and processed stress–strain curves for all materials, standard strength and ductility characteristics and the Johnson – Cook law of deformation and speed hardening were determined. For a correct assessment of the mechanical properties of additively produced materials, these tests were also carried out for each of them in the form of annealed rolled products. It is established that to compare the efficiency of various technological parameters of additive manufacturing, it is advisable to use static tensile strength and uniform elongation to rupture, having the smallest statistical variation. It was also found acceptable to approximate the Johnson – Cook law of the deformation curves of each of the studied materials according to averaged data, including various technological modes. Certain mechanical characteristics seem to be necessary for the search for effective modes of hybrid additive manufacturing and numerical calculation of various elastic-plastic problems in a dynamic formulation for the studied materials for design and technological needs.

The collapse of the Soviet Union, the large-scale transformation of the political and social structure in the early 1990s actualized the problem of nation-building in the new Russian state. The search for a “national idea” has contributed to the fact that over the past thirty years several dominant concepts of identity have changed in the Russian official discourse: from the denial of Soviet identity and the strategy of rapprochement with Western democracies to the construction of a great-power conservative identity of the “successor state”. The central place in the discourse of Russian identity is occupied by the problem of achieving social harmony through the elaboration of attitudes to the past, the construction of political values, the definition of symbolic boundaries of the political community. This research is devoted to the comparison of ideas about social harmony articulated within the framework of key concepts of post-Soviet identity of Russia.

The paper analyzes the working conditions of workers in the dairy industry, which showed that the prevailing harmful production factor is the increased noise level. It has been proven that noise has a negative impact not only on the hearing organs, but also on the whole organism as a whole as a general biological irritant, therefore, reducing noise expansion due to engineering solutions is an urgent task of our time. The article assesses the noise impact on operators of the dairy industry as part of a special assessment of working conditions. The analysis showed that the excess noise level is observed at all workplaces. To protect workers from an increased noise level, a design of a sound-suppressing piece sound absorber is proposed, which is distinguished by high sanitary and hygienic properties. The use of sound-suppressing piece sound absorbers will improve working conditions from a harmful class to an acceptable one.

Cancer is considered to be 3rd leading killer and 2nd among non-communicable diseases in Kenya Mutinda J. (2019). Ferlay, et al (2013) noted there are about 37,000 new cases of cancer annually and annual mortality rate of 28,000. This indicates cancer records rapidly accumulate over time and more resources are needed to collect and manage cancer-related data. KNH/UoN Department of Pathology have for a long time kept their records using a paper-based system. Objective of the study was to review current record keeping system including the process of preserving, storing and retrieving cancer records and the challenges faced, develop a model to guide the archival of locally available cancer paper-records and a web based prototype to preserve and avails this information to a wide range of stakeholders. The study used descriptive research design involving 22 participants. Random sampling technique was used to select respondents among the sampled population. The intervention prototype was developed using the RAD methodology. It was noted that cancer patient data were captured through standard forms/books (86% of the respondents) and stored in standard forms/books (71% of the respondents). 57% stated that identification of record and documenting was done based on LAB number. ICD 10 Coding system was not fully implemented as many forms had old coding format. 77% of the participants stated that the inability to track patient records with ease as a challenge and lack of technology in records management as a potential security bleach and damage of records. Findings presented a strong case for this research study where, upon prototype developed, there was concurrence among the respondents that the developed solution would be of significant to enhance cancer records management in the department and improving the healthcare service delivery process. This model can also be used to preserve other similar medical paper documents.

Introduction: Mental disorders are very serious complicated disorders. Schizophrenia is one of the most baffling mental disorders. The new series 7-(2-(benzo[d]thiazol-2- ylamino)ethoxy)-4-methyl-2H-chromen-2- synthesized in search of newer compounds for Schizophrenia. Methods: Synthesis is done by refluxing in dry pyridine with various substituted 2-amino benzothiazoles derivatives (3a-3k) and 7-(2-Chloroethoxy)-4-methyl-2H-chromen-2-one (2). The molecular docking approach was used to screen these generated derivatives. Chem Bio Draw Ultra 12 was used to draw the compounds, which were then exposed to all potential conformations of compounds interacting with receptors. The Glide 7.6, Schrodinger 2017 Maestro 11.3 was used to achieve molecular docking. The Dopamine receptor 6CM4 serotonin 5TUD PDBs were acquired from the database of Brookhaven Protein. Using the OPLS 2005 force field, the ligand-protein hydrogen-bond network was acquired, along with the overall energy reduced. A glide score was used to rate the docking poses. Results: The produced compounds have been identified with the use of analytical and spectral data. All of the produced substances were tested and analyzed for serotonin 5HT2 antagonistic and dopamine D2 activity, which can be considered as a measure of typical antipsychotic properties. Conclusion: Compounds 4b, 4c, 4e, 4g & 4i have demonstrated promising pharmacological action in preliminary studies. According to the preceding findings, compounds with electronwithdrawing substitutions, such as 4e & 4b, have a good atypical profile of antipsychotics.

Objective: Diabetic nephropathy is an unavoidable complication of chronic uncontrolled diabetes mellitus. The pathogenesis of diabetic nephropathy is multifactorial, and the development of an effective therapy remains to be elucidated. The aim of the present study was to assess the role of NOX2 and Nrf2 in the protective mechanism of thymoquinone (THQ) against streptozotocin (STZ)-induced diabetic nephropathy. Methods: Rats were injected with STZ (55 mg/kg) to induce diabetes. The diabetic rats were orally treated with THQ (10 mg/kg/day) for eight weeks. Results: STZ-treated rats exhibit an elevation of serum creatinine, serum urea, and creatinine clearance. The renal abnormalities were associated with increased NADPH oxidase isoform, NOX2 protein expression, and activity, along with elevated malondialdehyde (MDA). In addition, the tumor necrotic factor-alpha (TNF-α) level and nitric oxide (NO) bioavailability, as well as the transforming growth factor-beta (TGF)-β, were markedly increased. On the other hand, the nuclear factor-E2-related factor (Nrf2) protein expression was significantly reduced in diabetic rats compared to the control. However, treatment with THQ significantly reversed these alterations with subsequent ameliorating renal dysfunction and pathological abnormalities. Conclusion: The present study demonstrates that THQ could protect against STZ-induced diabetic nephropathy by modulating the Nrf2/NOX2 signaling pathway.

BACKGROUND: The long co-evolution of Homo sapiens and Plasmodium falciparum has resulted in the selection of numerous human genetic variants that confer an advantage against severe malaria and death. One such variant is the Dantu blood group antigen, which is associated with 74% protection against severe and complicated P. falciparum malaria infections in homozygous individuals, similar to that provided by the sickle haemoglobin allele (HbS). Recent in vitro studies suggest that Dantu exerts this protection by increasing the surface tension of red blood cells, thereby impeding the ability of P. falciparum merozoites to invade them and reducing parasite multiplication. However, no studies have yet explored this hypothesis in vivo. METHODS: We investigated the effect of Dantu on early phase P. falciparum (Pf) infections in a controlled human malaria infection (CHMI) study. 141 sickle-negative Kenyan adults were inoculated with 3.2 × 103 aseptic, purified, cryopreserved Pf sporozoites (PfSPZ Challenge) then monitored for blood-stage parasitaemia for 21 days by quantitative polymerase chain reaction (qPCR)analysis of the 18S ribosomal RNA P. falciparum gene. The primary endpoint was blood-stage P. falciparum parasitaemia of ≥500/μl while the secondary endpoint was the receipt of antimalarial treatment in the presence of parasitaemia of any density. On study completion, all participants were genotyped both for Dantu and for four other polymorphisms that are associated with protection against severe falciparum malaria: α+-thalassaemia, blood group O, G6PD deficiency, and the rs4951074 allele in the red cell calcium transporter ATP2B4. RESULTS: The primary endpoint was reached in 25/111 (22.5%) non-Dantu subjects in comparison to 0/27 (0%) Dantu heterozygotes and 0/3 (0.0%) Dantu homozygotes (p=0.01). Similarly, 49/111 (44.1%) non-Dantu subjects reached the secondary endpoint in comparison to only 7/27 (25.9%) and 0/3 (0.0%) Dantu heterozygotes and homozygotes, respectively (p=0.021). No significant impacts on either outcome were seen for any of the other genetic variants under study. CONCLUSIONS: This study reveals, for the first time, that the Dantu blood group is associated with high-level protection against early, non-clinical, P. falciparum malaria infections in vivo. Learning more about the mechanisms involved could potentially lead to new approaches to the prevention or treatment of the disease. Our study illustrates the power of CHMI with PfSPZ Challenge for directly testing the protective impact of genotypes previously identified using other methods. FUNDING: The Kenya CHMI study was supported by an award from Wellcome (grant number 107499). SK was supported by a Training Fellowship (216444/Z/19/Z), TNW by a Senior Research Fellowship (202800/Z/16/Z), JCR by an Investigator Award (220266/Z/20/Z), and core support to the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya (203077), all from Wellcome. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. For the purpose of Open Access, the authors have applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. CLINICAL TRIAL NUMBER: NCT02739763.

This paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at the LHC, using 139 fb$$^{-\text {1}}$$ - 1 of data collected with the ATLAS detector at a centre-of-mass energy of 13 TeV. The results are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. In addition, the results are interpreted in terms of upper limits on the Higgs boson invisible branching ratio, where the Higgs boson is produced according to the Standard Model in association with a pair of top quarks. For scalar (pseudoscalar) dark matter models, with all couplings set to unity, the statistical combination extends the mass range excluded by the best of the individual channels by 50 (25) GeV, excluding mediator masses up to 370 GeV. In addition, the statistical combination improves the expected coupling exclusion reach by 14% (24%), assuming a scalar (pseudoscalar) mediator mass of 10 GeV. An upper limit on the Higgs boson invisible branching ratio of 0.38 ($$\text {0.30}^{+\text {0.13}}_{-\text {0.09}}$$ 0.30 - 0.09 + 0.13 ) is observed (expected) at 95% confidence level.