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322 results on '"Skryabina A"'

1. Structure and mechanism of action of botulinum and tetanus neurotoxins: A review

Author: Anna A. Skryabina, Ekaterina S. Golenok, Maxim M. Sobkh, and Vladimir V. Nikiforov
Subjects: General Medicine
Abstract: Botulinum neurotoxins and tetanus neurotoxins are the strongest known toxins that cause neuroparalytic syndromes in botulism and tetanus. This review aimed to systematize scientific data on the structures and mechanism of actions of botulinum and tetanus neurotoxins. Botulinum and tetanus neurotoxins are proteins containing functional domains responsible for receptor binding, transmembrane translocation, and proteolytic cleavage of proteins required for exocytosis of synaptic vesicles and release of neurotransmitters into the synaptic cleft. The main stages of the botulinum neurotoxins and tetanus neurotoxin action include binding to the presynaptic membrane, internalization of bound toxin into the cytosol via endocytosis, translocation of the L-chain into the cytosol via the HN domain, disruption of the interchain disulfide bond with the release of the L-chain to express its catalytic activity (as a metalloprotease) in the cytosol, and selective cleavage of one or more soluble N-ethylmaleimide-sensitive factor attachment receptor complex proteins with subsequent blockade of neurotransmitter release.
Published: 2023

2. Subacute brucellosis: A case report

Author: Murad Z. Shakhmardanov, Vladimir V. Nikiforov, Nikita A. Tereshkin, Shakhmardan E. Shakhmardanov, Anna A. Skryabina, and Yuri N. Tomilin
Subjects: General Medicine
Abstract: Brucellosis is one of the most common zoonotic diseases worldwide. The epidemiological situation of brucellosis in the Russian Federation is characterized as unfavorable. Brucellosis remains a problem in regions with developed animal husbandry. The variety of clinical manifestations and the absence of specific symptoms of brucellosis make its diagnosis challenging. The clinical case presented in this paper illustrates the delayed diagnosis of brucellosis in a 10-year-old patient presenting with fever and enlarged lymph nodes, liver, and spleen. The failure in the provision of medical care was attributed to the lack of the alertness of doctors regarding brucellosis, insufficient interpretation of epidemiological history data, and incorrect assessment of the totality of the clinical syndrome of the disease and laboratory parameters. As a result, brucellosis was diagnosed only 6 months after disease onset. Subsequent etiotropic therapy led to the stabilization of the patients condition, who was discharged from the hospital with recommendations under the supervision of an infectious disease specialist.
Published: 2023

3. Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Rajesh Sharma, Mohsen Abbasi-Kangevari, Rami Abd-Rabu, Hassan Abidi, Eman Abu-Gharbieh, Juan Manuel Acuna, Sangeet Adhikari, Shailesh M Advani, Muhammad Sohail Afzal, Mohamad Aghaie Meybodi, Bright Opoku Ahinkorah, Sajjad Ahmad, Ali Ahmadi, Sepideh Ahmadi, Haroon Ahmed, Luai A Ahmed, Muktar Beshir Ahmed, Hanadi Al Hamad, Fares Alahdab, Fahad Mashhour Alanezi, Turki M Alanzi, Fadwa Alhalaiqa Naji Alhalaiqa, Yousef Alimohamadi, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Sami Almustanyir, Rajaa M Al-Raddadi, Saba Alvand, Nelson Alvis-Guzman, Saeed Amini, Robert Ancuceanu, Amir Anoushiravani, Ali Arash Anoushirvani, Alireza Ansari-Moghaddam, Jalal Arabloo, Armin Aryannejad, Mohammad Asghari Jafarabadi, Seyyed Shamsadin Athari, Floriane Ausloos, Marcel Ausloos, Atalel Fentahun Awedew, Mamaru Ayenew Awoke, Tegegn Mulatu Ayana, Sina Azadnajafabad, Hiva Azami, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ashish D Badiye, Sara Bagherieh, Saeed Bahadory, Atif Amin Baig, Jennifer L Baker, Maciej Banach, Amadou Barrow, Alemshet Yirga Berhie, Sima Besharat, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Sadia Bibi, Ali Bijani, Antonio Biondi, Tone Bjørge, Belay Boda Abule Bodicha, Dejana Braithwaite, Hermann Brenner, Daniela Calina, Chao Cao, Yin Cao, Giulia Carreras, Felix Carvalho, Ester Cerin, Raja Chandra Chakinala, William C S Cho, Dinh-Toi Chu, Joao Conde, Vera Marisa Costa, Natália Cruz-Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Anna Danielewicz, Feleke Mekonnen Demeke, Getu Debalkie Demissie, Rupak Desai, Deepak Dhamnetiya, Mostafa Dianatinasab, Daniel Diaz, Mojtaba Didehdar, Saeid Doaei, Linh Phuong Doan, Milad Dodangeh, Fatemeh Eghbalian, Debela Debela Ejeta, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Iman El Sayed, Muhammed Elhadi, Daniel Berhanie Enyew, Tahir Eyayu, Rana Ezzeddini, Ildar Ravisovich Fakhradiyev, Umar Farooque, Hossein Farrokhpour, Farshad Farzadfar, Ali Fatehizadeh, Hamed Fattahi, Nima Fattahi, Masood Fereidoonnezhad, Eduarda Fernandes, Getahun Fetensa, Irina Filip, Florian Fischer, Masoud Foroutan, Peter Andras Gaal, Mohamed M Gad, Silvano Gallus, Tushar Garg, Tamiru Getachew, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Nermin Ghith, Maryam Gholamalizadeh, Jamshid Gholizadeh Navashenaq, Abraham Tamirat Gizaw, James C Glasbey, Mahaveer Golechha, Pouya Goleij, Kebebe Bekele Gonfa, Giuseppe Gorini, Avirup Guha, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Nima Hafezi-Nejad, Arvin Haj-Mirzaian, Rabih Halwani, Shafiul Haque, Sanam Hariri, Ahmed I Hasaballah, Soheil Hassanipour, Simon I Hay, Claudiu Herteliu, Ramesh Holla, Mohammad-Salar Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Mowafa Househ, Junjie Huang, Ayesha Humayun, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Farhad Islami, Masao Iwagami, Mohammad Ali Jahani, Mihajlo Jakovljevic, Tahereh Javaheri, Ranil Jayawardena, Rime Jebai, Ravi Prakash Jha, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Jacek Jerzy Jozwiak, Ali Kabir, Rohollah Kalhor, Ashwin Kamath, Neeti Kapoor, Ibraheem M Karaye, Amirali Karimi, Joonas H Kauppila, Asma Kazemi, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Rovshan Khalilov, Javad Khanali, Maryam Khayamzadeh, Mahmoud Khodadost, Hanna Kim, Min Seo Kim, Adnan Kisa, Sezer Kisa, Ali-Asghar Kolahi, Hamid Reza Koohestani, Jacek A Kopec, Rajasekaran Koteeswaran, Ai Koyanagi, Yuvaraj Krishnamoorthy, G Anil Kumar, Manoj Kumar, Vivek Kumar, Carlo La Vecchia, Faris Hasan Lami, Iván Landires, Caterina Ledda, Sang-woong Lee, Wei-Chen Lee, Yeong Yeh Lee, Elvynna Leong, Bingyu Li, Stephen S Lim, Stany W Lobo, Joana A Loureiro, Raimundas Lunevicius, Farzan Madadizadeh, Ata Mahmoodpoor, Azeem Majeed, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Fariborz Mansour-Ghanaei, Lorenzo Giovanni Mantovani, Miquel Martorell, Sahar Masoudi, Prashant Mathur, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Walter Mendoza, Alexios-Fotios A Mentis, Tomislav Mestrovic, Junmei Miao Jonasson, Bartosz Miazgowski, Tomasz Miazgowski, Gelana Fekadu Worku Mijena, Seyyedmohammadsadeq Mirmoeeni, Mohammad Mirza-Aghazadeh-Attari, Hamed Mirzaei, Sanjeev Misra, Karzan Abdulmuhsin Mohammad, Esmaeil Mohammadi, Saeed Mohammadi, Seyyede Momeneh Mohammadi, Abdollah Mohammadian-Hafshejani, Shafiu Mohammed, Teroj Abdulrahman Mohammed, Nagabhishek Moka, Ali H Mokdad, Zeinab Mokhtari, Mariam Molokhia, Sara Momtazmanesh, Lorenzo Monasta, Ghobad Moradi, Rahmatollah Moradzadeh, Paula Moraga, Joana Morgado-da-Costa, Sumaira Mubarik, Francesk Mulita, Mohsen Naghavi, Mukhammad David Naimzada, Hae Sung Nam, Zuhair S Natto, Biswa Prakash Nayak, Javad Nazari, Ehsan Nazemalhosseini-Mojarad, Ionut Negoi, Cuong Tat Nguyen, Son Hoang Nguyen, Nurulamin M Noor, Maryam Noori, Seyyed Mohammad Ali Noori, Virginia Nuñez-Samudio, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Oluwakemi Ololade Odukoya, Ayodipupo Sikiru Oguntade, Hassan Okati-Aliabad, Andrew T Olagunju, Tinuke O Olagunju, Sokking Ong, Samuel M Ostroff, Alicia Padron-Monedero, Reza Pakzad, Adrian Pana, Anamika Pandey, Fatemeh Pashazadeh Kan, Urvish K Patel, Uttam Paudel, Renato B Pereira, Navaraj Perumalsamy, Richard G Pestell, Zahra Zahid Piracha, Richard Charles G Pollok, Akram Pourshams, Naeimeh Pourtaheri, Akila Prashant, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Sima Rafiei, Mosiur Rahman, Amir Masoud Rahmani, Vahid Rahmanian, Nazanin Rajai, Aashish Rajesh, Vajiheh Ramezani-Doroh, Kiana Ramezanzadeh, Kamal Ranabhat, Sina Rashedi, Amirfarzan Rashidi, Mahsa Rashidi, Mohammad-Mahdi Rashidi, Mandana Rastegar, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Andre M N Renzaho, Negar Rezaei, Nima Rezaei, Saeid Rezaei, Mohsen Rezaeian, Sahba Rezazadeh-Khadem, Gholamreza Roshandel, Maha Mohamed Saber-Ayad, Bahar Saberzadeh-Ardestani, Basema Saddik, Hossein Sadeghi, Umar Saeed, Maryam Sahebazzamani, Amirhossein Sahebkar, Amir Salek Farrokhi, Amir Salimi, Hamideh Salimzadeh, Pouria Samadi, Mehrnoosh Samaei, Abdallah M Samy, Juan Sanabria, Milena M Santric-Milicevic, Muhammad Arif Nadeem Saqib, Arash Sarveazad, Brijesh Sathian, Maheswar Satpathy, Ione Jayce Ceola Schneider, Mario Šekerija, Sadaf G Sepanlou, Allen Seylani, Feng Sha, Sayed Mohammad Shafiee, Zahra Shaghaghi, Saeed Shahabi, Elaheh Shaker, Maedeh Sharifian, Javad Sharifi-Rad, Sara Sheikhbahaei, Jeevan K Shetty, Reza Shirkoohi, Parnian Shobeiri, Sudeep K Siddappa Malleshappa, Diego Augusto Santos Silva, Guilherme Silva Julian, Achintya Dinesh Singh, Jasvinder A Singh, Md Shahjahan Siraj, Gholam Reza Sivandzadeh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Bogdan Socea, Marco Solmi, Mohammad Sadegh Soltani-Zangbar, Suhang Song, Viktória Szerencsés, Miklós Szócska, Rafael Tabarés-Seisdedos, Elnaz Tabibian, Majid Taheri, Yasaman TaheriAbkenar, Amir Taherkhani, Iman M Talaat, Ker-Kan Tan, Abdelghani Tbakhi, Bekele Tesfaye, Amir Tiyuri, Daniel Nigusse Tollosa, Mathilde Touvier, Bach Xuan Tran, Biruk Shalmeno Tusa, Irfan Ullah, Saif Ullah, Marco Vacante, Sahel Valadan Tahbaz, Massimiliano Veroux, Bay Vo, Theo Vos, Cong Wang, Ronny Westerman, Melat Woldemariam, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Fereshteh Yazdanpanah, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Mazyar Zahir, Iman Zare, Zhi-Jiang Zhang, Mohammad Zoladl, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Sharma, Rajesh, Abbasi-Kangevari, Mohsen, Abd-Rabu, Rami, Abidi, Hassan, Ahmed, Muktar Beshir, Zoladl, Mohammad, GBD 2019 Colorectal Cancer Collaborators, Sharma, R, Abbasi-Kangevari, M, Abd-Rabu, R, Abidi, H, Abu-Gharbieh, E, Manuel Acuna, J, Adhikari, S, M Advani, S, Sohail Afzal, M, Aghaie Meybodi, M, Opoku Ahinkorah, B, Ahmad, S, Ahmadi, A, Ahmadi, S, Ahmed, H, A Ahmed, L, Beshir Ahmed, M, Al Hamad, H, Alahdab, F, Mashhour Alanezi, F, M Alanzi, T, Alhalaiqa Naji Alhalaiqa, F, Alimohamadi, Y, Alipour, V, Mohamed Aljunid, S, Alkhayyat, M, Almustanyir, S, M Al-Raddadi, R, Alvand, S, Alvis-Guzman, N, Amini, S, Ancuceanu, R, Anoushiravani, A, Arash Anoushirvani, A, Ansari-Moghaddam, A, Arabloo, J, Aryannejad, A, Asghari Jafarabadi, M, Shamsadin Athari, S, Ausloos, F, Ausloos, M, Fentahun Awedew, A, Ayenew Awoke, M, Mulatu Ayana, T, Azadnajafabad, S, Azami, H, Azangou-Khyavy, M, Azari Jafari, A, D Badiye, A, Bagherieh, S, Bahadory, S, Amin Baig, A, L Baker, J, Banach, M, Barrow, A, Yirga Berhie, A, Besharat, S, S Bhagat, D, Srikanth Bhagavathula, A, Bhala, N, Bhattacharyya, K, S Bhojaraja, V, Bibi, S, Bijani, A, Biondi, A, Bj??rge, T, Boda Abule Bodicha, B, Braithwaite, D, Brenner, H, Calina, D, Cao, C, Cao, Y, Carreras, G, Carvalho, F, Cerin, E, Chandra Chakinala, R, S Cho, W, Chu, D, Conde, J, Marisa Costa, V, Cruz-Martins, N, Dadras, O, Dai, X, Dandona, L, Dandona, R, Danielewicz, A, Mekonnen Demeke, F, Debalkie Demissie, G, Desai, R, Dhamnetiya, D, Dianatinasab, M, Diaz, D, Didehdar, M, Doaei, S, Phuong Doan, L, Dodangeh, M, Eghbalian, F, Debela Ejeta, D, Ekholuenetale, M, Cyrus Ekundayo, T, El Sayed, I, Elhadi, M, Berhanie Enyew, D, Eyayu, T, Ezzeddini, R, Ravisovich Fakhradiyev, I, Farooque, U, Farrokhpour, H, Farzadfar, F, Fatehizadeh, A, Fattahi, H, Fattahi, N, Fereidoonnezhad, M, Fernandes, E, Fetensa, G, Filip, I, Fischer, F, Foroutan, M, Andras Gaal, P, M Gad, M, Gallus, S, Garg, T, Getachew, T, Ghamari, S, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gholizadeh Navashenaq, J, Tamirat Gizaw, A, C Glasbey, J, Golechha, M, Goleij, P, Bekele Gonfa, K, Gorini, G, Guha, A, Gupta, S, Bala Gupta, V, Kumar Gupta, V, Haddadi, R, Hafezi-Nejad, N, Haj-Mirzaian, A, Halwani, R, Haque, S, Hariri, S, I Hasaballah, A, Hassanipour, S, I Hay, S, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Stephen Ilesanmi, O, M Ilic, I, D Ilic, M, Islami, F, Iwagami, M, Ali Jahani, M, Jakovljevic, M, Javaheri, T, Jayawardena, R, Jebai, R, Prakash Jha, R, Joo, T, Joseph, N, Joukar, F, Jerzy Jozwiak, J, Kabir, A, Kalhor, R, Kamath, A, Kapoor, N, M Karaye, I, Karimi, A, H Kauppila, J, Kazemi, A, Keykhaei, M, Saleh Khader, Y, Khajuria, H, Khalilov, R, Khanali, J, Khayamzadeh, M, Khodadost, M, Kim, H, Seo Kim, M, Kisa, A, Kisa, S, Kolahi, A, Reza Koohestani, H, A Kopec, J, Koteeswaran, R, Koyanagi, A, Krishnamoorthy, Y, Anil Kumar, G, Kumar, M, Kumar, V, La Vecchia, C, Hasan Lami, F, Landires, I, Ledda, C, Lee, S, Lee, W, Yeh Lee, Y, Leong, E, Li, B, S Lim, S, W Lobo, S, A Loureiro, J, Lunevicius, R, Madadizadeh, F, Mahmoodpoor, A, Majeed, A, Malekpour, M, Malekzadeh, R, Azam Malik, A, Mansour-Ghanaei, F, Mantovani, L, Martorell, M, Masoudi, S, Mathur, P, Kumar Meena, J, Mehrabi Nasab, E, Mendoza, W, A Mentis, A, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Fekadu Worku Mijena, G, Mirmoeeni, S, Mirza-Aghazadeh-Attari, M, Mirzaei, H, Misra, S, Abdulmuhsin Mohammad, K, Mohammadi, E, Mohammadi, S, Momeneh Mohammadi, S, Mohammadian-Hafshejani, A, Mohammed, S, Abdulrahman Mohammed, T, Moka, N, H Mokdad, A, Mokhtari, Z, Molokhia, M, Momtazmanesh, S, Monasta, L, Moradi, G, Moradzadeh, R, Moraga, P, Morgado-da-Costa, J, Mubarik, S, Mulita, F, Naghavi, M, David Naimzada, M, Sung Nam, H, S Natto, Z, Prakash Nayak, B, Nazari, J, Nazemalhosseini-Mojarad, E, Negoi, I, Tat Nguyen, C, Hoang Nguyen, S, M Noor, N, Noori, M, Mohammad Ali Noori, S, Nu??ez-Samudio, V, Igwegbe Nzoputam, C, Oancea, B, Ololade Odukoya, O, Sikiru Oguntade, A, Okati-Aliabad, H, T Olagunju, A, O Olagunju, T, Ong, S, M Ostroff, S, Padron-Monedero, A, Pakzad, R, Pana, A, Pandey, A, Pashazadeh Kan, F, K Patel, U, Paudel, U, B Pereira, R, Perumalsamy, N, G Pestell, R, Zahid Piracha, Z, G Pollok, R, Pourshams, A, Pourtaheri, N, Prashant, A, Rabiee, M, Rabiee, N, Radfar, A, Rafiei, S, Rahman, M, Masoud Rahmani, A, Rahmanian, V, Rajai, N, Rajesh, A, Ramezani-Doroh, V, Ramezanzadeh, K, Ranabhat, K, Rashedi, S, Rashidi, A, Rashidi, M, Rastegar, M, Laith Rawaf, D, Rawaf, S, Rawassizadeh, R, Sadegh Razeghinia, M, N Renzaho, A, Rezaei, N, Rezaei, S, Rezaeian, M, Rezazadeh-Khadem, S, Roshandel, G, Mohamed Saber-Ayad, M, Saberzadeh-Ardestani, B, Saddik, B, Sadeghi, H, Saeed, U, Sahebazzamani, M, Sahebkar, A, Salek Farrokhi, A, Salimi, A, Salimzadeh, H, Samadi, P, Samaei, M, M Samy, A, Sanabria, J, M Santric-Milicevic, M, Arif Nadeem Saqib, M, Sarveazad, A, Sathian, B, Satpathy, M, Jayce Ceola Schneider, I, ekerija, M, G Sepanlou, S, Seylani, A, Sha, F, Mohammad Shafiee, S, Shaghaghi, Z, Shahabi, S, Shaker, E, Sharifian, M, Sharifi-Rad, J, Sheikhbahaei, S, K Shetty, J, Shirkoohi, R, Shobeiri, P, K Siddappa Malleshappa, S, Augusto Santos Silva, D, Silva Julian, G, Dinesh Singh, A, A Singh, J, Shahjahan Siraj, M, Reza Sivandzadeh, G, Yurievich Skryabin, V, Aleksandrovna Skryabina, A, Socea, B, Solmi, M, Sadegh Soltani-Zangbar, M, Song, S, Szerencs??s, V, Sz??cska, M, Tabar??s-Seisdedos, R, Tabibian, E, Taheri, M, Taheriabkenar, Y, Taherkhani, A, M Talaat, I, Tan, K, Tbakhi, A, Tesfaye, B, Tiyuri, A, Nigusse Tollosa, D, Touvier, M, Xuan Tran, B, Shalmeno Tusa, B, Ullah, I, Ullah, S, Vacante, M, Valadan Tahbaz, S, Veroux, M, Vo, B, Vos, T, Wang, C, Westerman, R, Woldemariam, M, Hossein Yahyazadeh Jabbari, S, Yang, L, Yazdanpanah, F, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zahir, M, Zare, I, Zhang, Z, Zoladl, M, Sharma, R., Abbasi-Kangevari, M., Abd-Rabu, R., Abidi, H., Abu-Gharbieh, E., Acuna, J. M., Adhikari, S., Advani, S. M., Afzal, M. S., Aghaie Meybodi, M., Ahinkorah, B. O., Ahmad, S., Ahmadi, A., Ahmadi, S., Ahmed, H., Ahmed, L. A., Ahmed, M. B., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alanzi, T. M., Alhalaiqa, F. A. N., Alimohamadi, Y., Alipour, V., Aljunid, S. M., Alkhayyat, M., Almustanyir, S., Al-Raddadi, R. M., Alvand, S., Alvis-Guzman, N., Amini, S., Ancuceanu, R., Anoushiravani, A., Anoushirvani, A. A., Ansari-Moghaddam, A., Arabloo, J., Aryannejad, A., Asghari Jafarabadi, M., Athari, S. S., Ausloos, F., Ausloos, M., Awedew, A. F., Awoke, M. A., Ayana, T. M., Azadnajafabad, S., Azami, H., Azangou-Khyavy, M., Azari Jafari, A., Badiye, A. D., Bagherieh, S., Bahadory, S., Baig, A. A., Baker, J. L., Banach, M., Barrow, A., Berhie, A. Y., Besharat, S., Bhagat, D. S., Bhagavathula, A. S., Bhala, N., Bhattacharyya, K., Bhojaraja, V. S., Bibi, S., Bijani, A., Biondi, A., Bjorge, T., Bodicha, B. B. A., Braithwaite, D., Brenner, H., Calina, D., Cao, C., Cao, Y., Carreras, G., Carvalho, F., Cerin, E., Chakinala, R. C., Cho, W. C. S., Chu, D. -T., Conde, J., Costa, V. M., Cruz-Martins, N., Dadras, O., Dai, X., Dandona, L., Dandona, R., Danielewicz, A., Demeke, F. M., Demissie, G. D., Desai, R., Dhamnetiya, D., Dianatinasab, M., Diaz, D., Didehdar, M., Doaei, S., Doan, L. P., Dodangeh, M., Eghbalian, F., Ejeta, D. D., Ekholuenetale, M., Ekundayo, T. C., El Sayed, I., Elhadi, M., Enyew, D. B., Eyayu, T., Ezzeddini, R., Fakhradiyev, I. R., Farooque, U., Farrokhpour, H., Farzadfar, F., Fatehizadeh, A., Fattahi, H., Fattahi, N., Fereidoonnezhad, M., Fernandes, E., Fetensa, G., Filip, I., Fischer, F., Foroutan, M., Gaal, P. A., Gad, M. M., Gallus, S., Garg, T., Getachew, T., Ghamari, S. -H., Ghashghaee, A., Ghith, N., Gholamalizadeh, M., Gholizadeh Navashenaq, J., Gizaw, A. T., Glasbey, J. C., Golechha, M., Goleij, P., Gonfa, K. B., Gorini, G., Guha, A., Gupta, S., Gupta, V. B., Gupta, V. K., Haddadi, R., Hafezi-Nejad, N., Haj-Mirzaian, A., Halwani, R., Haque, S., Hariri, S., Hasaballah, A. I., Hassanipour, S., Hay, S. I., Herteliu, C., Holla, R., Hosseini, M. -S., Hosseinzadeh, M., Hostiuc, M., Househ, M., Huang, J., Humayun, A., Iavicoli, I., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Islami, F., Iwagami, M., Jahani, M. A., Jakovljevic, M., Javaheri, T., Jayawardena, R., Jebai, R., Jha, R. P., Joo, T., Joseph, N., Joukar, F., Jozwiak, J. J., Kabir, A., Kalhor, R., Kamath, A., Kapoor, N., Karaye, I. M., Karimi, A., Kauppila, J. H., Kazemi, A., Keykhaei, M., Khader, Y. S., Khajuria, H., Khalilov, R., Khanali, J., Khayamzadeh, M., Khodadost, M., Kim, H., Kim, M. S., Kisa, A., Kisa, S., Kolahi, A. -A., Koohestani, H. R., Kopec, J. A., Koteeswaran, R., Koyanagi, A., Krishnamoorthy, Y., Kumar, G. A., Kumar, M., Kumar, V., La Vecchia, C., Lami, F. H., Landires, I., Ledda, C., Lee, S. -W., Lee, W. -C., Lee, Y. Y., Leong, E., Li, B., Lim, S. S., Lobo, S. W., Loureiro, J. A., Lunevicius, R., Madadizadeh, F., Mahmoodpoor, A., Majeed, A., Malekpour, M. -R., Malekzadeh, R., Malik, A. A., Mansour-Ghanaei, F., Mantovani, L. G., Martorell, M., Masoudi, S., Mathur, P., Meena, J. K., Mehrabi Nasab, E., Mendoza, W., Mentis, A. -F. A., Mestrovic, T., Miao Jonasson, J., Miazgowski, B., Miazgowski, T., Mijena, G. F. W., Mirmoeeni, S., Mirza-Aghazadeh-Attari, M., Mirzaei, H., Misra, S., Mohammad, K. A., Mohammadi, E., Mohammadi, S., Mohammadi, S. M., Mohammadian-Hafshejani, A., Mohammed, S., Mohammed, T. A., Moka, N., Mokdad, A. H., Mokhtari, Z., Molokhia, M., Momtazmanesh, S., Monasta, L., Moradi, G., Moradzadeh, R., Moraga, P., Morgado-da-Costa, J., Mubarik, S., Mulita, F., Naghavi, M., Naimzada, M. D., Nam, H. S., Natto, Z. S., Nayak, B. P., Nazari, J., Nazemalhosseini-Mojarad, E., Negoi, I., Nguyen, C. T., Nguyen, S. H., Noor, N. M., Noori, M., Noori, S. M. A., Nunez-Samudio, V., Nzoputam, C. I., Oancea, B., Odukoya, O. O., Oguntade, A. S., Okati-Aliabad, H., Olagunju, A. T., Olagunju, T. O., Ong, S., Ostroff, S. M., Padron-Monedero, A., Pakzad, R., Pana, A., Pandey, A., Pashazadeh Kan, F., Patel, U. K., Paudel, U., Pereira, R. B., Perumalsamy, N., Pestell, R. G., Piracha, Z. Z., Pollok, R. C. G., Pourshams, A., Pourtaheri, N., Prashant, A., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, S., Rahman, M., Rahmani, A. M., Rahmanian, V., Rajai, N., Rajesh, A., Ramezani-Doroh, V., Ramezanzadeh, K., Ranabhat, K., Rashedi, S., Rashidi, A., Rashidi, M., Rashidi, M. -M., Rastegar, M., Rawaf, D. L., Rawaf, S., Rawassizadeh, R., Razeghinia, M. S., Renzaho, A. M. N., Rezaei, N., Rezaei, S., Rezaeian, M., Rezazadeh-Khadem, S., Roshandel, G., Saber-Ayad, M. M., Saberzadeh-Ardestani, B., Saddik, B., Sadeghi, H., Saeed, U., Sahebazzamani, M., Sahebkar, A., Salek Farrokhi, A., Salimi, A., Salimzadeh, H., Samadi, P., Samaei, M., Samy, A. M., Sanabria, J., Santric-Milicevic, M. M., Saqib, M. A. N., Sarveazad, A., Sathian, B., Satpathy, M., Schneider, I. J. C., Sekerija, M., Sepanlou, S. G., Seylani, A., Sha, F., Shafiee, S. M., Shaghaghi, Z., Shahabi, S., Shaker, E., Sharifian, M., Sharifi-Rad, J., Sheikhbahaei, S., Shetty, J. K., Shirkoohi, R., Shobeiri, P., Siddappa Malleshappa, S. K., Silva, D. A. S., Silva Julian, G., Singh, A. D., Singh, J. A., Siraj, M. S., Sivandzadeh, G. R., Skryabin, V. Y., Skryabina, A. A., Socea, B., Solmi, M., Soltani-Zangbar, M. S., Song, S., Szerencses, V., Szocska, M., Tabares-Seisdedos, R., Tabibian, E., Taheri, M., Taheriabkenar, Y., Taherkhani, A., Talaat, I. M., Tan, K. -K., Tbakhi, A., Tesfaye, B., Tiyuri, A., Tollosa, D. N., Touvier, M., Tran, B. X., Tusa, B. S., Ullah, I., Ullah, S., Vacante, M., Valadan Tahbaz, S., Veroux, M., Vo, B., Vos, T., Wang, C., Westerman, R., Woldemariam, M., Yahyazadeh Jabbari, S. H., Yang, L., Yazdanpanah, F., Yu, C., Yuce, D., Yunusa, I., Zadnik, V., Zahir, M., Zare, I., Zhang, Z. -J., Zoladl, M., Epidemiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, and Bill & Melinda Gates Foundation
Subjects: Adult, MED/42 - IGIENE GENERALE E APPLICATA, IMPACT, colorectal cancer, Colorectal Neoplasm, GBD 2019 Colorectal Cancer Collaborators, HEREDITARY, Global Burden of Disease, Cancer screening, DISPARITIES, SDG 3 - Good Health and Well-being, Cancer treatment strategies, Risk Factors, Quality-Adjusted Life Year, COLON, Global studies, DALY, GBD, colorectal cancer, risk factors, Humans, Global Burden of Disease Study, Early Detection of Cancer, Hepatology, MORTALITY, Gastroenterology, Cancer incidence rates, Middle Aged, Cancer burden, SURVIVAL, SEX, GENDER, Quality-Adjusted Life Years, Colorectal Neoplasms, Human
Abstract: Correction to Lancet Gastroenterol Hepatol 2022; 7: 627-47. Lancet Gastroenterol Hepatol. 2022 Aug;7(8):704. doi: 10.1016/S2468-1253(22)00210-2. PMID: 35809605. Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990-2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408-868 574) to 2·17 million (2·00-2·34), and deaths increased from 518 126 (493 682-537 877) to 1·09 million (1·02-1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3-23·0) per 100 000 to 26·7 (24·6-28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5-14·9) per 100 000 to 13·7 (12·6-14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7-320·7) per 100 000 to 295·5 (275·2-313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9-80·0] per 100 000), Monaco (60·7 [48·5-73·6] per 100 000), and Andorra (56·6 [42·8-71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0-37·1] per 100 000), Brunei (30·3 [26·6-34·1] per 100 000), and Hungary (28·6 [23·6-34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age
Published: 2022

4. Morphofunctional Changes in Neurons, Glial Cells and Synapses in the Sensorimotor Cortex after Severe Traumatic Brain Injury

Author: А. Yu. Shoronova, V. A. Akulinin, S. S. Stepanov, M. S. Korzhuk, L. M. Makar'eva, D. B. Avdeev, O. V. Skryabina, and I. G. Tsuskman
Subjects: Automotive Engineering
Abstract: The aim of the study was to investigate morphofunctional modifications in neurons, glial cells and synaptic terminals in the sensorimotor cortex of the brain in rats after severe traumatic brain injury (STBI).Material and methods. STBI simulation in white rats (main group, n=30) was performed on a device with a special shock mechanism. Intact animals (n=6) were included in the control group. The sensorimotor cortex (SMC) of the brain in rats was studied histomorphologically on sections stained with hematoxylin and eosin and thionin according to Nissl. Synaptophysin and GFAP were detected immunohistochemically, then morphometry was performed. On serial frontal sections of the SMC, neurons, neuroglia, and interneuronal synapses were studied in animals of the control group and in animals exposed to STBI in 1, 3, 7, 14, and 30 days after STBI simulation. The number density of neurons, neuroglia, and synaptic terminals was determined per a unit area of the section of layers I (terminals only), III, and V of the cerebral SMC. Statistical hypotheses were tested using nonparametric methods in the Statistica 10.0 program.Results. In animals of the control group, typical normochromic pyramidal neurons predominated, synaptic terminals were clearly verified; this was combined with unaltered neuropil. In animals exposed to STBI, there were signs of tinctorial, hydropic, dehydration and necrobiotic changes in neurons, reactive astrogliosis, fields of "loss" of neurons appeared; the overall numerical density of neurons and synapses decreased. The maximally increased content of pycnomorphic neurons was detected in 1 day after STBI (in layer III of the SMC, by 11.6%; in layer V of the SMC, by 18.5%). The peak in the number density of shadow cells and hyperchromic non-wrinkled neurons was noted in 3 days. The numerical density of synaptic terminals in different layers of the SMC decreased by 1.5-2 times. The altered balance of the destruction and restoration processes of the synaptic pool after STBI was evidenced by statistically significant data on the decreased and increased numerical density of terminals during 30 days of the study. There was no complete recovery of the studied parameters of neurons and synapses to control values within 30 days.Conclusion. The SMC of the brain in rats remains functioning after STBI; this occurs in the context of long-term preservation of reversibly and irreversibly damaged neurons, reactive neurogliosis, and permanent reorganization of interneuronal relationships due to activated reparative neuro- and synaptic plasticity. The data obtained will specify reorganization of the components of various neuronal complexes of the SMC (layers I, III, and V) after STBI.
Published: 2023

5. Trade damper effect of regional trade agreements

Author: V. N. Zuev, E. Y. Ostrovskaya, and V. Y. Skryabina
Subjects: Economics and Econometrics, History, General Economics, Econometrics and Finance, Finance
Abstract: The authors explore the impact of crises on the dynamics of trade between partners within regional trade agreements (RTAs) with the aim to determine whether RTAs have a stabilizing effect on foreign trade. RTAs have become one of the main instruments of trade policy in recent decades. It is generally recognized that RTAs do stimulate trade at the time of stability and growth. It is logical to assume that meeting commitments between RTA partners should lead to the preservation of trade flows between them in the event of a crisis. However, this statement requires empirical confirmation. The study examines the effects of RTA networks for the three most active RTAs’ participants located on different continents — the EU, Chile and the Republic of Korea. The analysis of dynamics of these countries trade flows indicates a clear trend of strengthening trade interaction between RTA partners during crisis periods. The focus of the methodology of the study lies in computations of three trade indices: export significance index, trade intensity index and symmetric trade introversion index. They were calculated for the totality of trade partners for the EU, Chile and the Republic of Korea from 2005 to 2020 in order to identify the dominant tendencies of trade flows during periods of economic shocks of recent decades (the financial crisis of 2008—2009 and the crisis caused by the pandemic of 2019—2021). The authors come to the conclusion that for the studied countries and the EU RTAs act as a damper that reduces the negative impact of crises on foreign trade. Trade between RTA countries at the time of a crisis either decreased to a lesser extent compared to trade between countries that do not have RTA, or recovered faster. This empirically confirms yet another significant importance of RTAs. The authors suggest to make similar calculations for other countries and RTAs to support the revealed pattern.
Published: 2023

6. Generalized tetanus: a case report

Author: Murad Z. Shakhmardanov, Vladimir V. Nikiforov, Anna A. Skryabina, Svetlana V. Burova, Yuri N. Tomilin, Aida S. Abusueva, and Natalya A. Antipyat
Abstract: Tetanus is a rare disease caused by Clostridium tetani, causing damage to the central nervous system with the development of muscle hypertension and attacks of generalized seizures caused by the action of the pathogenic toxin. Despite the availability of safe and effective vaccines, the urgency of the problem of tetanus incidence is high because a significant part of the population is not immunized against this disease, and severe manifestations of tetanus can be fatal. This paper presents a clinical case of traumatic generalized tetanus in an 11-year-old patient. The absence of routine immunization against tetanus and emergency activepassive immunization contributed to disease development. The disease proceeded in a typical form, with the development of muscle spasms, myoclonia, trism, and convulsions. Specific tetanus serum was administered, pathogenetic therapy with anticonvulsants and muscle relaxants was performed, and the patient had clinical recovery and was discharged from the hospital.
Published: 2023

7. Adverse drug reactions of macrolide therapy: analysis of spontaneous reports according to the Pharmacovigilance system

Author: A.A. Skryabina, V.V. Nikiforov, M.Z. Shakhmardanov, M.S. Zastrozhin, V.Yu. Skryabin, and D.A. Sychev
Subjects: Microbiology (medical), Infectious Diseases, Epidemiology, Pharmacology (medical)
Abstract: Objective. To perform pharmacoepidemiological analysis of spontaneous reports of adverse drug reactions (ADRs) occurred during macrolide group antibiotics prescription and registered in the “Pharmacovigilance 2.0” subsystem of the Federal Service for Surveillance in Healthcare. Materials and Methods. A retrospective pharmacoepidemiological analysis of spontaneous reports of ADRs arising from the use of all macrolide and azalide antibiotics registered in Russia and registered in the electronic database of the “Pharmacovigilance 2.0” subsystem of the Federal Service for Surveillance in Healthcare for the period from 01.04.2019 to 30.11.2022 was performed. Results. Analysis of the number of spontaneous reports of ADRs, their structure, outcomes and severity criteria was performed. The most clinically significant ADRs were identified, the occurrence of which was reported to pharmacovigilance bodies. The results of a retrospective pharmacoepidemiological analysis showed that the development of complications of pharmacotherapy in most cases was associated with the use of azithromycin and clarithromycin. The main clinical manifestations of adverse drug reactions were skin and subcutaneous tissue disorders, gastrointestinal disorders, as well as general disorders and injection site reactions. Conclusions. It was found that the reported events generally corresponded to the general spectrum of ADRs typical for individual representatives of macrolide and azalide antibiotics.
Published: 2023

8. Energy conditions for the formation of magnesium hydride

Author: V. N Aptukov, N. E Skryabina, and D. Fruchart
Subjects: Mechanics of Materials, Materials Science (miscellaneous), Computational Mechanics
Abstract: In the present article we consider a novel approach to analyze the processes and kinetics of transformation of magnesium to hydride. Here approach consists to take into account the contributions of mechanics factors such as the work of external forces, the energy of elastic deformation and the energy required to form a unit volume nucleate of new phase. Request for a stable state of either a mechanical system or thermodynamic conditions governing a phase transformation, is to determine a minimum value to the total energy of the system. Analyzing the stability conditions needed when forming a metal hydride nucleus at constant temperature and pressure needs to consider the following: - the volumetric effects at the phase transformation, - the ratio of elastic moduli of metal to hydride phase, - the work spent at the formation of a unit volume of hydride. Under these considerations, it was shown that the most energetically favorable is forming an ellipsoidal hydride nucleus. Moreover, the larger difference in semi-axes, the more stable ellipsoid nucleus. Then, calculations of the stress-strain level states on both sides of the metal/hydride interface have been carried out. It was shown that the near-boundary range during the phase transformation is the place where accumulate inhomogeneous and intense stresses, which can contribute to two parallel processes. Firstly, increase of hydrogen concentration could appear in the distorted area. Secondly, a local accumulation of incoherent boundaries in between the two phases will develop stresses exceeding by more twice the shear yield stress. The presence of these compression zones could give rise new defects such as dislocations, micro-cracks. Consequently this should lead to decrease in magnitude of the powder of material.
Published: 2022

9. Актуальные вопросы патогенетического лечения болезни Фабри в Российской Федерации S. Moiseev L.M. Kuzenkova N.D. Vashakamadse E.M. Shilov O.N. Kotenko T.V. Podkletnova A.N. Semyachkina M.S. Harlap <jats:abstract xml:lang='en'> <jats:p></jats:p> </jats:abstract> <month>12</month> <day>03</day> 2022 <month>11</month> <day>03</day> 2022 66 68</last_page> 10.32756/0869-5490-2022-4-66-68 https://clinpharm-journal.ru/articles/2022-4/aktualnye-voprosy-patogeneticheskogo-lecheniya-bolezni-fabri-v-rossijskoj-federatsii/ Macrolide antibiotics: chemical structure, mechanism of action and safety issues

Author: D.A. Sychev, M.S. Zastrozhin, M.Z. Shakhmardanov, V.V. Nikiforov, and A.A. Skryabina
Abstract: The article provides an overview of current publications on the chemical structure, mechanism of action and safety of macrolide antibiotics. We conducted a search in PubMed and Google Scholar databases for the scientific articles published from 2010 to 2021. The following key words were used: macrolides, macrolide antibiotics, erythromycin, clarithromycin, azithromycin, mechanism of action, adverse drug reactions, toxicity. Macrolides are broad-spectrum antibiotics used to treat a wide range of both local and systemic infectious diseases. Macrolides are generally safe, although they can induce certain dose-dependent adverse drug reactions.
Published: 2022

10. Long Single Au Nanowires in Nb/Au/Nb Josephson Junctions: Implications for Superconducting Microelectronics

Author: Stepan V. Sotnichuk, Olga V. Skryabina, Andrey G. Shishkin, Sergey V. Bakurskiy, Mikhail Yu. Kupriyanov, Vasily S. Stolyarov, and Kirill S. Napolskii
Subjects: General Materials Science
Published: 2022

11. Challenges in the diagnosis of coxiellosis and the perspectives of personalized treatment

Author: Ya Yankovskaya, T Chekanova, M Kutateladze, K Petremgvdlishvili, T Chernobrovkina, and A Skryabina
Subjects: General Medicine
Published: 2022

12. Global burden of chronic respiratory diseases and risk factors, 1990-2019: an update from the Global Burden of Disease Study 2019

Author: Momtazmanesh, Sara, Moghaddam, Sahar Saeedi, Ghamari, Seyyed-Hadi, Rad, Elaheh Malakan, Rezaei, Negar, Shobeiri, Parnian, Aali, Amirali, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdoun, Meriem, Abdulah, Deldar Morad, Md Abdullah, Abu Yousuf, Abedi, Aidin, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Achappa, Basavaprabhu, Adane Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adnan, Mohammad, Sakilah Adnani, Qorinah Estiningtyas, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Keivan, Ahmed, Ali, Ahmed, Ayman, Rashid, Tarik Ahmed, Al Hamad, Hanadi, Alahdab, Fares, Alemayehu, Astawus, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Almustanyir, Sami, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Dehkordi, Javad Aminian, Amir-Behghadami, Mehrdad, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Antony, Catherine M., Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arulappan, Judie, Ashraf, Tahira, Athari, Seyyed Shamsadin, Attia, Engi F., Ayele, Meshesha Tsegazeab, Azadnajafabad, Sina, Babu, Abraham Samuel, Bagherieh, Sara, Baltatu, Ovidiu Constantin, Banach, Maciej, Bardhan, Mainak, Barone-Adesi, Francesco, Barrow, Amadou, Basu, Saurav, Bayileyegn, Nebiyou Simegnew, Bensenor, Isabela M., Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhat, Ajay Nagesh, Bhattacharyya, Krittika, Bouaoud, Souad, Braithwaite, Dejana, Brauer, Michael, Butt, Muhammad Hammad, Butt, Zahid A., Calina, Daniela, Cámera, Luis Alberto, Chanie, Gashaw Sisay, Charalampous, Periklis, Chattu, Vijay Kumar, Chimed-Ochir, Odgerel, Chu, Dinh-Toi, Cohen, Aaron J., Cruz-Martins, Natália, Dadras, Omid, Darwesh, Aso Mohammad, Das, Saswati, Debela, Sisay Abebe, Delgado-Ortiz, Laura, Dereje, Diriba, Dianatinasab, Mostafa, Diao, Nancy, Diaz, Daniel, Digesa, Lankamo Ena, Dirirsa, Gebisa, Doku, Paul Narh, Dongarwar, Deepa, Douiri, Abdel, Dsouza, Haneil Larson, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, Mustafa Elagali, Ahmed Elabbas, Elhadi, Muhammed, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Etaee, Farshid, Fagbamigbe, Adeniyi Francis, Faro, Andre, Fatehizadeh, Ali, Fekadu, Ginenus, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Franklin, Richard Charles, Gaal, Peter Andras, Gaihre, Santosh, Gaipov, Abduzhappar, Gebrehiwot, Mesfin, Gerema, Urge, Getachew, Motuma Erena, Getachew, Tamiru, Ghafourifard, Mansour, Ghanbari, Reza, Ghashghaee, Ahmad, Gholami, Ali, Gil, Artyom Urievich, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Guadie, Habtamu Alganeh, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Hadei, Mostafa, Halwani, Rabih, Hanif, Asif, Hargono, Arief, Harorani, Mehdi, Hartono, Risky Kusuma, Hasani, Hamidreza, Hashi, Abdiwahab, Hay, Simon I., Heidari, Mohammad, Hellemons, Merel E., Herteliu, Claudiu, Holla, Ramesh, Horita, Nobuyuki, Hoseini, Mohammad, Hosseinzadeh, Mehdi, Huang, Junjie, Hussain, Salman, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ibrahim, Sufyan, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Immurana, Mustapha, Ismail, Nahlah Elkudssiah, Merin J, Linda, Jakovljevic, Mihajlo, Jamshidi, Elham, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jha, Ravi Prakash, Johnson, Olatunji, Joo, Tamas, Joseph, Nitin, Jozwiak, Jacek Jerzy, K, Vaishali, Kaambwa, Billingsley, Kabir, Zubair, Kalankesh, Laleh R., Kalhor, Rohollah, Kandel, Himal, Karanth, Shama D., Karaye, Ibraheem M., Kassa, Bekalu Getnet, Kassie, Gizat M., Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khajuria, Himanshu, Khan, Imteyaz A., Khan, Moien A. B., Khan, Yusra H., Khreis, Haneen, Kim, Min Seo, Kisa, Adnan, Kisa, Sezer, Knibbs, Luke D., Kolkhir, Pavel, Komaki, Somayeh, Kompani, Farzad, Koohestani, Hamid Reza, Koolivand, Ali, Korzh, Oleksii, Koyanagi, Ai, Krishan, Kewal, Krohn, Kris J., Kumar, Naveen, Kumar, Nithin, Kurmi, Om P., Kuttikkattu, Ambily, La Vecchia, Carlo, Lám, Judit, Lan, Qing, Lasrado, Savita, Latief, Kamaluddin, Lauriola, Paolo, Lee, Sang-woong, Lee, Yo Han, Legesse, Samson Mideksa, Lenzi, Jacopo, Li, Ming-Chieh, Lin, Ro-Ting, Liu, Gang, Liu, Wei, Lo, Chun-Han, Lorenzovici, László, Lu, Yifei, Mahalingam, Soundarya, Mahmoudi, Elham, Mahotra, Narayan B., Malekpour, Mohammad-Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansouri, Borhan, Mathews, Elezebeth, Maulud, Sazan Qadir, Mechili, Enkeleint A., Nasab, Entezar Mehrabi, Menezes, Ritesh G., Mengistu, Dechasa Adare, Mentis, Alexios-Fotios, Meshkat, Mahboobeh, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Mirrakhimov, Erkin M., Misganaw, Awoke, Mithra, Prasanna, Moghadasi, Javad, Mohammadi, Esmaeil, Mohammadi, Mokhtar, Mohammadshahi, Marita, Mohammed, Shafiu, Mohan, Syam, Moka, Nagabhishek, Monasta, Lorenzo, Moni, Mohammad Ali, Moniruzzaman, Md, Montazeri, Fateme, Moradi, Maryam, Mostafavi, Ebrahim, Mpundu-Kaambwa, Christine, Murillo-Zamora, Efrén, Murray, Christopher J. L., Nair, Tapas Sadasivan, Nangia, Vinay, Swamy, Sreenivas Narasimha, Narayana, Aparna Ichalangod, Natto, Zuhair S., Nayak, Biswa Prakash, Negash, Wogene Wogene, Nena, Evangelia, Kandel, Sandhya Neupane, Niazi, Robina Khan, Nogueira de Sá, Antonio Tolentino, Nowroozi, Ali, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obaidur, Rahman Md, Odukoya, Oluwakemi Ololade, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Olagunju, Andrew T., Bali, Ahmed Omar, Ostojic, Sergej M., A, Mahesh P., Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pahlevan Fallahy, Mohammad Taha, Palicz, Tamás, Pana, Adrian, Park, Eun-Kee, Patel, Jay, Paudel, Rajan, Paudel, Uttam, Pedersini, Paolo, Pereira, Marcos, Pereira, Renato B., Petcu, Ionela-Roxana, Pirestani, Majid, Postma, Maarten J., Prashant, Akila, Rabiee, Mohammad, Radfar, Amir, Rafiei, Sima, Rahim, Fakher, Ur Rahman, Mohammad Hifz, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmanian, Vahid, Rajput, Prashant, Rana, Juwel, Rao, Chythra R., Rao, Sowmya J., Rashedi, Sina, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Mohamed Redwan, Elrashdy Moustafa, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Nima, Rezaeian, Mohsen, Rodrigues, Mónica, Buendia Rodriguez, Jefferson Antonio, Roever, Leonardo, Rojas-Rueda, David, Rudd, Kristina E., Saad, Aly M. A., Sabour, Siamak, Saddik, Basema, Sadeghi, Erfan, Sadeghi, Masoumeh, Saeed, Umar, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Sahoo, Harihar, Sajid, Mirza Rizwan, Sakhamuri, Sateesh, Salehi, Sana, Samy, Abdallah M., Santric-Milicevic, Milena M., Sao Jose, Bruno Piassi, Sathian, Brijesh, Satpathy, Maheswar, Saya, Ganesh Kumar, Senthilkumaran, Subramanian, Seylani, Allen, Shahabi, Saeed, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sheikhi, Rahim Ali, Shekhar, Shashank, Sibhat, Migbar Mekonnen, Simpson, Colin R., Singh, Jasvinder A., Singh, Paramdeep, Singh, Surjit, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani-Zangbar, Mohammad Sadegh, Song, Suhang, Soyiri, Ireneous N., Steiropoulos, Paschalis, Stockfelt, Leo, Sun, Jing, Takahashi, Ken, Talaat, Iman M., Tan, Ker-Kan, Tat, Nathan Y., Tat, Vivian Y., Taye, Birhan Tsegaw, Thangaraju, Pugazhenthan, Thapar, Rekha, Thienemann, Friedrich, Tiyuri, Amir, Ngoc Tran, Mai Thi, Tripathy, Jaya Prasad, Car, Lorainne Tudor, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Sana, Vacante, Marco, Valdez, Pascual R., Valizadeh, Rohollah, van Boven, Job F. M., Vasankari, Tommi Juhani, Vaziri, Siavash, Violante, Francesco S., Vo, Bay, Wang, Ning, Wei, Melissa Y., Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Xu, Suowen, Xu, Xiaoyue, Yadav, Lalit, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Yu, Yong, Yunusa, Ismaeel, Zahir, Mazyar, Zangiabadian, Moein, Zareshahrabadi, Zahra, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zegeye, Zelalem Banjaw, Zhang, Yunquan, Naghavi, Mohsen, Larijani, Bagher, Farzadfar, Farshad, Surgery, Erasmus MC other, Public Health, Pulmonary Medicine, GVO PSY, Ophthalmology, Momtazmanesh, Sara, Moghaddam, Sahar Saeedi, Ghamari, Seyyed-Hadi, Rad, Elaheh Malakan, Rezaei, Negar, Shobeiri, Parnian, Aali, Amirali, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdelmasseh, Michael, Abdoun, Meriem, Abdulah, Deldar Morad, Md Abdullah, Abu Yousuf, Abedi, Aidin, Abolhassani, Hassan, Abrehdari-Tafreshi, Zahra, Achappa, Basavaprabhu, Adane Adane, Denberu Eshetie, Adane, Tigist Demssew, Addo, Isaac Yeboah, Adnan, Mohammad, Sakilah Adnani, Qorinah Estiningtya, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Keivan, Ahmed, Ali, Ahmed, Ayman, Rashid, Tarik Ahmed, Al Hamad, Hanadi, Alahdab, Fare, Alemayehu, Astawu, Alif, Sheikh Mohammad, Aljunid, Syed Mohamed, Almustanyir, Sami, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Dehkordi, Javad Aminian, Amir-Behghadami, Mehrdad, Ancuceanu, Robert, Andrei, Catalina Liliana, Andrei, Tudorel, Antony, Catherine M., Anyasodor, Anayochukwu Edward, Arabloo, Jalal, Arulappan, Judie, Ashraf, Tahira, Athari, Seyyed Shamsadin, Attia, Engi F., Ayele, Meshesha Tsegazeab, Azadnajafabad, Sina, Babu, Abraham Samuel, Bagherieh, Sara, Baltatu, Ovidiu Constantin, Banach, Maciej, Bardhan, Mainak, Barone-Adesi, Francesco, Barrow, Amadou, Basu, Saurav, Bayileyegn, Nebiyou Simegnew, Bensenor, Isabela M., Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhat, Ajay Nagesh, Bhattacharyya, Krittika, Bouaoud, Souad, Braithwaite, Dejana, Brauer, Michael, Butt, Muhammad Hammad, Butt, Zahid A., Calina, Daniela, Cámera, Luis Alberto, Chanie, Gashaw Sisay, Charalampous, Perikli, Chattu, Vijay Kumar, Chimed-Ochir, Odgerel, Chu, Dinh-Toi, Cohen, Aaron J., Cruz-Martins, Natália, Dadras, Omid, Darwesh, Aso Mohammad, Das, Saswati, Debela, Sisay Abebe, Delgado-Ortiz, Laura, Dereje, Diriba, Dianatinasab, Mostafa, Diao, Nancy, Diaz, Daniel, Digesa, Lankamo Ena, Dirirsa, Gebisa, Doku, Paul Narh, Dongarwar, Deepa, Douiri, Abdel, Dsouza, Haneil Larson, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyru, Mustafa Elagali, Ahmed Elabba, Elhadi, Muhammed, Enyew, Daniel Berhanie, Erkhembayar, Ryenchindorj, Etaee, Farshid, Fagbamigbe, Adeniyi Franci, Faro, Andre, Fatehizadeh, Ali, Fekadu, Ginenu, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Franklin, Richard Charle, Gaal, Peter Andra, Gaihre, Santosh, Gaipov, Abduzhappar, Gebrehiwot, Mesfin, Gerema, Urge, Getachew, Motuma Erena, Getachew, Tamiru, Ghafourifard, Mansour, Ghanbari, Reza, Ghashghaee, Ahmad, Gholami, Ali, Gil, Artyom Urievich, Golechha, Mahaveer, Goleij, Pouya, Golinelli, Davide, Guadie, Habtamu Alganeh, Gupta, Bhawna, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Hadei, Mostafa, Halwani, Rabih, Hanif, Asif, Hargono, Arief, Harorani, Mehdi, Hartono, Risky Kusuma, Hasani, Hamidreza, Hashi, Abdiwahab, Hay, Simon I., Heidari, Mohammad, Hellemons, Merel E., Herteliu, Claudiu, Holla, Ramesh, Horita, Nobuyuki, Hoseini, Mohammad, Hosseinzadeh, Mehdi, Huang, Junjie, Hussain, Salman, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ibrahim, Sufyan, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Immurana, Mustapha, Ismail, Nahlah Elkudssiah, Merin J, Linda, Jakovljevic, Mihajlo, Jamshidi, Elham, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jha, Ravi Prakash, Johnson, Olatunji, Joo, Tama, Joseph, Nitin, Jozwiak, Jacek Jerzy, K, Vaishali, Kaambwa, Billingsley, Kabir, Zubair, Kalankesh, Laleh R., Kalhor, Rohollah, Kandel, Himal, Karanth, Shama D., Karaye, Ibraheem M., Kassa, Bekalu Getnet, Kassie, Gizat M., Keikavoosi-Arani, Leila, Keykhaei, Mohammad, Khajuria, Himanshu, Khan, Imteyaz A., Khan, Moien A.B., Khan, Yusra H., Khreis, Haneen, Kim, Min Seo, Kisa, Adnan, Kisa, Sezer, Knibbs, Luke D., Kolkhir, Pavel, Komaki, Somayeh, Kompani, Farzad, Koohestani, Hamid Reza, Koolivand, Ali, Korzh, Oleksii, Koyanagi, Ai, Krishan, Kewal, Krohn, Kris J., Kumar, Naveen, Kumar, Nithin, Kurmi, Om P., Kuttikkattu, Ambily, La Vecchia, Carlo, Lám, Judit, Lan, Qing, Lasrado, Savita, Latief, Kamaluddin, Lauriola, Paolo, Lee, Sang-woong, Lee, Yo Han, Legesse, Samson Mideksa, Lenzi, Jacopo, Li, Ming-Chieh, Lin, Ro-Ting, Liu, Gang, Liu, Wei, Lo, Chun-Han, Lorenzovici, László, Lu, Yifei, Mahalingam, Soundarya, Mahmoudi, Elham, Mahotra, Narayan B., Malekpour, Mohammad-Reza, Malik, Ahmad Azam, Mallhi, Tauqeer Hussain, Malta, Deborah Carvalho, Mansouri, Borhan, Mathews, Elezebeth, Maulud, Sazan Qadir, Mechili, Enkeleint A., Nasab, Entezar Mehrabi, Menezes, Ritesh G., Mengistu, Dechasa Adare, Mentis, Alexios-Fotio, Meshkat, Mahboobeh, Mestrovic, Tomislav, Micheletti Gomide Nogueira de Sá, Ana Carolina, Mirrakhimov, Erkin M., Misganaw, Awoke, Mithra, Prasanna, Moghadasi, Javad, Mohammadi, Esmaeil, Mohammadi, Mokhtar, Mohammadshahi, Marita, Mohammed, Shafiu, Mohan, Syam, Moka, Nagabhishek, Monasta, Lorenzo, Moni, Mohammad Ali, Moniruzzaman, Md, Montazeri, Fateme, Moradi, Maryam, Mostafavi, Ebrahim, Mpundu-Kaambwa, Christine, Murillo-Zamora, Efrén, Murray, Christopher J.L., Nair, Tapas Sadasivan, Nangia, Vinay, Swamy, Sreenivas Narasimha, Narayana, Aparna Ichalangod, Natto, Zuhair S., Nayak, Biswa Prakash, Negash, Wogene Wogene, Nena, Evangelia, Kandel, Sandhya Neupane, Niazi, Robina Khan, Nogueira de Sá, Antonio Tolentino, Nowroozi, Ali, Nzoputam, Chimezie Igwegbe, Nzoputam, Ogochukwu Janet, Oancea, Bogdan, Obaidur, Rahman Md, Odukoya, Oluwakemi Ololade, Okati-Aliabad, Hassan, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Olagunju, Andrew T., Bali, Ahmed Omar, Ostojic, Sergej M., A, Mahesh P., Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pahlevan Fallahy, Mohammad Taha, Palicz, Tamá, Pana, Adrian, Park, Eun-Kee, Patel, Jay, Paudel, Rajan, Paudel, Uttam, Pedersini, Paolo, Pereira, Marco, Pereira, Renato B., Petcu, Ionela-Roxana, Pirestani, Majid, Postma, Maarten J., Prashant, Akila, Rabiee, Mohammad, Radfar, Amir, Rafiei, Sima, Rahim, Fakher, Ur Rahman, Mohammad Hifz, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmanian, Vahid, Rajput, Prashant, Rana, Juwel, Rao, Chythra R., Rao, Sowmya J., Rashedi, Sina, Rashidi, Mohammad-Mahdi, Ratan, Zubair Ahmed, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Mohamed Redwan, Elrashdy Moustafa, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Nima, Rezaeian, Mohsen, Rodrigues, Mónica, Buendia Rodriguez, Jefferson Antonio, Roever, Leonardo, Rojas-Rueda, David, Rudd, Kristina E., Saad, Aly M.A., Sabour, Siamak, Saddik, Basema, Sadeghi, Erfan, Sadeghi, Masoumeh, Saeed, Umar, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Sahoo, Harihar, Sajid, Mirza Rizwan, Sakhamuri, Sateesh, Salehi, Sana, Samy, Abdallah M., Santric-Milicevic, Milena M., Sao Jose, Bruno Piassi, Sathian, Brijesh, Satpathy, Maheswar, Saya, Ganesh Kumar, Senthilkumaran, Subramanian, Seylani, Allen, Shahabi, Saeed, Shaikh, Masood Ali, Shanawaz, Mohd, Shannawaz, Mohammed, Sheikhi, Rahim Ali, Shekhar, Shashank, Sibhat, Migbar Mekonnen, Simpson, Colin R., Singh, Jasvinder A., Singh, Paramdeep, Singh, Surjit, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani-Zangbar, Mohammad Sadegh, Song, Suhang, Soyiri, Ireneous N., Steiropoulos, Paschali, Stockfelt, Leo, Sun, Jing, Takahashi, Ken, Talaat, Iman M., Tan, Ker-Kan, Tat, Nathan Y., Tat, Vivian Y., Taye, Birhan Tsegaw, Thangaraju, Pugazhenthan, Thapar, Rekha, Thienemann, Friedrich, Tiyuri, Amir, Ngoc Tran, Mai Thi, Tripathy, Jaya Prasad, Car, Lorainne Tudor, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Sana, Vacante, Marco, Valdez, Pascual R., Valizadeh, Rohollah, van Boven, Job F.M., Vasankari, Tommi Juhani, Vaziri, Siavash, Violante, Francesco S., Vo, Bay, Wang, Ning, Wei, Melissa Y., Westerman, Ronny, Wickramasinghe, Nuwan Darshana, Xu, Suowen, Xu, Xiaoyue, Yadav, Lalit, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yu, Chuanhua, Yu, Yong, Yunusa, Ismaeel, Zahir, Mazyar, Zangiabadian, Moein, Zareshahrabadi, Zahra, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zegeye, Zelalem Banjaw, Zhang, Yunquan, Naghavi, Mohsen, Larijani, Bagher, Farzadfar, Farshad, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), and Groningen Research Institute for Asthma and COPD (GRIAC)
Subjects: Pulmonary emphysema, Lung disease, Morbidity, Epidemiology, Chronic obstructive pulmonary disease, Interstitial lung disease, General Medicine, Pneumoconiosi, Asthma, SDG 3 - Good Health and Well-being, Mortality, Pneumoconiosis
Abstract: Background: Updated data on chronic respiratory diseases (CRDs) are vital in their prevention, control, and treatment in the path to achieving the third UN Sustainable Development Goals (SDGs), a one-third reduction in premature mortality from non-communicable diseases by 2030. We provided global, regional, and national estimates of the burden of CRDs and their attributable risks from 1990 to 2019.Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we estimated mortality, years lived with disability, years of life lost, disability-adjusted life years (DALYs), prevalence, and incidence of CRDs, i.e. chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease and pulmonary sarcoidosis, and other CRDs, from 1990 to 2019 by sex, age, region, and Socio-demographic Index (SDI) in 204 countries and territories. Deaths and DALYs from CRDs attributable to each risk factor were estimated according to relative risks, risk exposure, and the theoretical minimum risk exposure level input. Findings: In 2019, CRDs were the third leading cause of death responsible for 4.0 million deaths (95% uncertainty interval 3.6–4.3) with a prevalence of 454.6 million cases (417.4–499.1) globally. While the total deaths and prevalence of CRDs have increased by 28.5% and 39.8%, the age-standardised rates have dropped by 41.7% and 16.9% from 1990 to 2019, respectively. COPD, with 212.3 million (200.4–225.1) prevalent cases, was the primary cause of deaths from CRDs, accounting for 3.3 million (2.9–3.6) deaths. With 262.4 million (224.1–309.5) prevalent cases, asthma had the highest prevalence among CRDs. The age-standardised rates of all burden measures of COPD, asthma, and pneumoconiosis have reduced globally from 1990 to 2019. Nevertheless, the age-standardised rates of incidence and prevalence of interstitial lung disease and pulmonary sarcoidosis have increased throughout this period. Low- and low-middle SDI countries had the highest age-standardised death and DALYs rates while the high SDI quintile had the highest prevalence rate of CRDs. The highest deaths and DALYs from CRDs were attributed to smoking globally, followed by air pollution and occupational risks. Non-optimal temperature and high body-mass index were additional risk factors for COPD and asthma, respectively.Interpretation: Albeit the age-standardised prevalence, death, and DALYs rates of CRDs have decreased, they still cause a substantial burden and deaths worldwide. The high death and DALYs rates in low and low-middle SDI countries highlights the urgent need for improved preventive, diagnostic, and therapeutic measures. Global strategies for tobacco control, enhancing air quality, reducing occupational hazards, and fostering clean cooking fuels are crucial steps in reducing the burden of CRDs, especially in low- and lower-middle income countries. Funding: Bill & Melinda Gates Foundation.
Published: 2023
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13. Professor N. N. Algazina’s methodological legacy and the present

Author: O. A. Skryabina
Subjects: Building and Construction
Abstract: The paper presents an analysis of the research legacy left behind by Professor, Doctor of Pedagogical Sciences Nadezhda Nikolayevna Algazina. The study updates the major achievements made by N. N. Algazina and her school. These include: developing the theory of spelling methodology and its basic concepts (orthogram, variant of an orthogram, identifying features of an orthogram, the theory of the variants of orthogram difficulties); creating the educational strand «Computer support of Russian lessons» and describing its methodological foundations in order to include digital technologies in the traditional lesson of the Russian language; practical testing of the created electronic textbooks and packages of educational computer programs in all sections of the Russian language course. The paper concludes with the idea that the scientist’s legacy is relevant as it has not declined in importance. What is more, it continues to develop in scientists’ research and practicing teachers’ activity.
Published: 2022

14. Development of approaches for studying the biodistribution of a bicistronic therapeutic plasmid construct in the mouse body

Author: S. S. Dzhauari, M. N. Karagyaur, V. Yu. Balabanyan, M. N. Skryabina, A. L. Primak, and D. V. Stambolsky
Subjects: General Earth and Planetary Sciences, General Environmental Science
Abstract: Relevance. The use of gene therapy drugs for the treatment of genetic diseases and stimulation of regeneration processes is lengthy and involves repeated injections, which may lead to increased dissemination of gene therapy constructs from the injection site and undesirable ectopic expression of growth factors encoded in them. Existing approaches to study the pharmacokinetics of a drug to assess the dissemination of a gene therapy drug from the site of administration are not applicable. Objective: to evaluate the suitability of the real-time PCR method for studying the biodistribution of a promising gene therapy drug in mice during a course of use. Methods. Male F1 CBA×C57/Black mice after nerve injury were injected with the test plasmid into the denervated tibial muscle after nerve injury, as well as after 4, 9 and 13 days at a dosage of 60 and 120 μg/mouse. After 7, 14, and 28 days, organ and tissue samples were removed, total DNA was isolated, and plasmid DNA content was assessed by real-time PCR. Results. We have shown that the studied genetic construct is able to disseminate from the injection site. We have found that the peak of dissemination for this construct in the organs and tissues of the mouse is reached 14–28 days after the end of the course application, while ectopic expression of growth factors is not observed in them. Conclusion. The proposed method is specific, highly sensitive, and linear over a wide range of concentrations. Thus, it can be recommended for studying the biodistribution of potential gene therapy drugs in the body of experimental animals as part of a preclinical studies complex.
Published: 2022

15. Properties of 2-CNF mutually dual and self-dual T_0 -topologies on a finite set and calculation of T_0-topologies of a certain weight

Author: Nadia Bashova, Polina Stegantseva, and Anna Skryabina
Subjects: Applied Mathematics, Geometry and Topology, Analysis
Abstract: The problem of counting non-homeomorphic topologies as well as all topologies on an n-elements set is still open. The topologies with the weight k>2n-1, where k is the number of the elements of the topology on an n-elements set, which are called close to the discrete topology have been studied completely. Moreover R.~Stanley in 1971, M.~Kolli in 2007 and in 2014 have been found the number of T0-topologies on an n-elements set with weights k≥7·2n-4, k ≥3·2n-3, and k≥5·2n-4 respectively. In the present paper we investigate T0-topologies using the topology vector, being an ordered set of the nonnegative integers that define the minimal neighborhoods of the elements of the given finite set, and also using the special form of 2-CNF of Boolean function. In 2021 the authors found the form of the vector of T0-topologies with k≥5·2n-4 and the values k∈[5·2n-4, 2n-1], for which there are no T0-topologies with the weight k. The method of describing of T0-topologies using the special form of 2-CNF of Boolean function is used for the identification of the mutually dual and self-dual T0-topologies, and the properties of such 2-CNF Boolean function are used for counting T0-topologies with the weight 25·2n-6.
Published: 2022

16. Some dysfunctions of the process of socialization of Russian youth in the context of 'big' challenges

Author: V. A. Smirnov, O. B. Skryabina, and T. I. Bessonova
Subjects: General Engineering
Abstract: Based on the results of an empirical study, the article analyzes some features of the socialization of Russian youth in modern society. The authors focus on the perception of the state by the youth, the problems facing it, as well as the analysis of the effectiveness of the project activities of the younger generation. The article concludes about the stereotyping of the Russian state, about the existence of rigid cognitive structures in the minds of the younger generation that limit its innovative potential. The authors believe that modern Russian youth is not ready to actualize and solve the global problems facing Russia. Equally important is the conclusion about the imitative nature of the system of development of project competencies of young people. This leads to a shortage of innovative leaders, technological and social entrepreneurs, and effective project managers.
Published: 2022

17. Kinetic Model and Mechanism of Hydrogenation of Unsaturated Carbocyclic Compounds Based on Norbornadiene

Author: V. V. Zamalyutin, E. A. Katsman, A. V. Ryabov, A. Yu. Skryabina, M. A. Shpinyova, V. Ya. Danyushevsky, and V. R. Flid
Subjects: Modeling and Simulation, General Chemistry, Catalysis, Computer Science Applications
Published: 2022

18. The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study

Author: Juanita A. Haagsma, Periklis Charalampous, Filippo Ariani, Anne Gallay, Kim Moesgaard Iburg, Evangelia Nena, Che Henry Ngwa, Alexander Rommel, Ausra Zelviene, Kedir Hussein Abegaz, Hanadi Al Hamad, Luciana Albano, Catalina Liliana Andrei, Tudorel Andrei, Ippazio Cosimo Antonazzo, Olatunde Aremu, Ashokan Arumugam, Alok Atreya, Avinash Aujayeb, Jose Luis Ayuso-Mateos, Luchuo Engelbert Bain, Maciej Banach, Till Winfried Bärnighausen, Francesco Barone-Adesi, Massimiliano Beghi, Derrick A. Bennett, Akshaya S. Bhagavathula, Félix Carvalho, Giulio Castelpietra, Ledda Caterina, Joht Singh Chandan, Rosa A. S. Couto, Natália Cruz-Martins, Giovanni Damiani, Anna Dastiridou, Andreas K. Demetriades, Diana Dias-da-Silva, Adeniyi Francis Fagbamigbe, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Florian Fischer, Urbano Fra.Paleo, Silvia Ghirini, James C. Glasbey, Ionela-Roxana Glavan, Nelson G. M. Gomes, Michal Grivna, Netanja I. Harlianto, Josep Maria Haro, M. Tasdik Hasan, Sorin Hostiuc, Ivo Iavicoli, Milena D. Ilic, Irena M. Ilic, Mihajlo Jakovljevic, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jürisson, Joonas H. Kauppila, Gbenga A. Kayode, Moien A. B. Khan, Adnan Kisa, Sezer Kisa, Ai Koyanagi, Manasi Kumar, Om P. Kurmi, Carlo La-Vecchia, Demetris Lamnisos, Savita Lasrado, Paolo Lauriola, Shai Linn, Joana A. Loureiro, Raimundas Lunevicius, Aurea Madureira-Carvalho, Enkeleint A. Mechili, Azeem Majeed, Ritesh G. Menezes, Alexios-Fotios A. Mentis, Atte Meretoja, Tomislav Mestrovic, Tomasz Miazgowski, Bartosz Miazgowski, Andreea Mirica, Mariam Molokhia, Shafiu Mohammed, Lorenzo Monasta, Francesk Mulita, Mukhammad David Naimzada, Ionut Negoi, Subas Neupane, Bogdan Oancea, Hans Orru, Adrian Otoiu, Nikita Otstavnov, Stanislav S. Otstavnov, Alicia Padron-Monedero, Songhomitra Panda-Jonas, Shahina Pardhan, Jay Patel, Paolo Pedersini, Marina Pinheiro, Ivo Rakovac, Chythra R. Rao, Salman Rawaf, David Laith Rawaf, Violet Rodrigues, Luca Ronfani, Dominic Sagoe, Francesco Sanmarchi, Milena M. Santric-Milicevic, Brijesh Sathian, Aziz Sheikh, Rahman Shiri, Siddharudha Shivalli, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Catalin-Gabriel Smarandache, Bogdan Socea, Raúl A. R. C. Sousa, Paschalis Steiropoulos, Rafael Tabarés-Seisdedos, Marcos Roberto Tovani-Palone, Fimka Tozija, Sarah Van de Velde, Tommi Juhani Vasankari, Massimiliano Veroux, Francesco S. Violante, Vasiliy Vlassov, Yanzhong Wang, Ali Yadollahpour, Sanni Yaya, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Suzanne Polinder, Marek Majdan, Haagsma, J, Charalampous, P, Ariani, F, Gallay, A, Moesgaard Iburg, K, Nena, E, Ngwa, C, Rommel, A, Zelviene, A, Abegaz, K, Al Hamad, H, Albano, L, Liliana Andrei, C, Andrei, T, Antonazzo, I, Aremu, O, Arumugam, A, Atreya, A, Aujayeb, A, Ayuso-Mateos, J, Engelbert Bain, L, Banach, M, Winfried Bärnighausen, T, Barone-Adesi, F, Beghi, M, Bennett, D, Bhagavathula, A, Carvalho, F, Castelpietra, G, Caterina, L, Chandan, J, Couto, R, Cruz-Martins, N, Damiani, G, Dastiridou, A, Demetriades, A, Dias-da-Silva, D, Francis Fagbamigbe, A, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Fischer, F, Fra. Paleo, U, Ghirini, S, Glasbey, J, Glavan, I, Gomes, N, Grivna, M, Harlianto, N, Haro, J, Hasan, M, Hostiuc, S, Iavicoli, I, Ilic, M, Ilic, I, Jakovljevic, M, Jonas, J, Jerzy Jozwiak, J, Jürisson, M, Kauppila, J, Kayode, G, Khan, M, Kisa, A, Kisa, S, Koyanagi, A, Kumar, M, Kurmi, O, La-Vecchia, C, Lamnisos, D, Lasrado, S, Lauriola, P, Linn, S, Loureiro, J, Lunevicius, R, Madureira-Carvalho, A, Mechili, E, Majeed, A, Menezes, R, Mentis, A, Meretoja, A, Mestrovic, T, Miazgowski, T, Miazgowski, B, Mirica, A, Molokhia, M, Mohammed, S, Monasta, L, Mulita, F, David Naimzada, M, Negoi, I, Neupane, S, Oancea, B, Orru, H, Otoiu, A, Otstavnov, N, Otstavnov, S, Padron-Monedero, A, Panda-Jonas, S, Pardhan, S, Patel, J, Pedersini, P, Pinheiro, M, Rakovac, I, Rao, C, Rawaf, S, Rawaf, D, Rodrigues, V, Ronfani, L, Sagoe, D, Sanmarchi, F, Santric-Milicevic, M, Sathian, B, Sheikh, A, Shiri, R, Shivalli, S, Dora Sigfusdottir, I, Sigurvinsdottir, R, Yurievich Skryabin, V, Aleksandrovna Skryabina, A, Smarandache, C, Socea, B, Sousa, R, Steiropoulos, P, Tabarés-Seisdedos, R, Roberto Tovani-Palone, M, Tozija, F, Van de Velde, S, Juhani Vasankari, T, Veroux, M, Violante, F, Vlassov, V, Wang, Y, Yadollahpour, A, Yaya, S, Sergeevich Zastrozhin, M, Zastrozhina, A, Polinder, S, Majdan, M, Haagsma, J. A., Charalampous, P., Ariani, F., Gallay, A., Moesgaard Iburg, K., Nena, E., Ngwa, C. H., Rommel, A., Zelviene, A., Abegaz, K. H., Al Hamad, H., Albano, L., Liliana Andrei, C., Andrei, T., Antonazzo, I. C., Aremu, O., Arumugam, A., Atreya, A., Aujayeb, A., Ayuso-Mateos, J. L., Engelbert Bain, L., Banach, M., Winfried Barnighausen, T., Barone-Adesi, F., Beghi, M., Bennett, D. A., Bhagavathula, A. S., Carvalho, F., Castelpietra, G., Caterina, L., Chandan, J. S., Couto, R. A. S., Cruz-Martins, N., Damiani, G., Dastiridou, A., Demetriades, A. K., Dias-da-Silva, D., Fagbamigbe, A. F., Fereshtehnejad, S. -M., Fernandes, E., Ferrara, P., Fischer, F., Fr, a. Paleo U., Ghirini, S., Glasbey, J. C., Glavan, I. -R., Gomes, N. G. M., Grivna, M., Harlianto, N. I., Haro, J. M., Hasan, M. T., Hostiuc, S., Iavicoli, I., Ilic, M. D., Ilic, I. M., Jakovljevic, M., Jonas, J. B., Jerzy Jozwiak, J., Jurisson, M., Kauppila, J. H., Kayode, G. A., Khan, M. A. B., Kisa, A., Kisa, S., Koyanagi, A., Kumar, M., Kurmi, O. P., La-Vecchia, C., Lamnisos, D., Lasrado, S., Lauriola, P., Linn, S., Loureiro, J. A., Lunevicius, R., Madureira-Carvalho, A., Mechili, E. A., Majeed, A., Menezes, R. G., Mentis, A. -F. A., Meretoja, A., Mestrovic, T., Miazgowski, T., Miazgowski, B., Mirica, A., Molokhia, M., Mohammed, S., Monasta, L., Mulita, F., David Naimzada, M., Negoi, I., Neupane, S., Oancea, B., Orru, H., Otoiu, A., Otstavnov, N., Otstavnov, S. S., Padron-Monedero, A., Panda-Jonas, S., Pardhan, S., Patel, J., Pedersini, P., Pinheiro, M., Rakovac, I., Rao, C. R., Rawaf, S., Rawaf, D. L., Rodrigues, V., Ronfani, L., Sagoe, D., Sanmarchi, F., Santric-Milicevic, M. M., Sathian, B., Sheikh, A., Shiri, R., Shivalli, S., Dora Sigfusdottir, I., Sigurvinsdottir, R., Yurievich Skryabin, V., Aleksandrovna Skryabina, A., Smarandache, C. -G., Socea, B., Sousa, R. A. R. C., Steiropoulos, P., Tabares-Seisdedos, R., Roberto Tovani-Palone, M., Tozija, F., Van de Velde, S., Juhani Vasankari, T., Veroux, M., Violante, F. S., Vlassov, V., Wang, Y., Yadollahpour, A., Yaya, S., Sergeevich Zastrozhin, M., Zastrozhina, A., Polinder, S., Majdan, M., Haagsma, Ja, Iburg, Km, Ngwa, Ch, Abegaz, Kh, Andrei, Cl, Antonazzo, Ic, Ayuso-Mateos, Jl, Bain, Le, Barnighausen, Tw, Bennett, Da, Couto, Ra, Demetriades, Ak, Fagbamigbe, Af, Fereshtehnejad, Sm, Fra Paleo, U, Glasbey, Jc, Glavan, Ir, Gomes, Ngm, Harlianto, Ni, Haro, Jm, Hasan, Mt, Ilic, Md, Ilic, Im, Jonas, Jb, Jozwiak, Jj, Jurisson, M, Kauppila, Jh, Kayode, Ga, Khan, Mab, Kurmi, Op, Loureiro, Ja, Mechili, Ea, Menezes, Rg, Mentis, Afa, Naimzada, Md, Rao, Cr, Rawaf, Dl, Santric-Milicevic, Mm, Sigfusdottir, Id, Skryabin, Vy, Skryabina, Aa, Smarandache, Cg, Sousa, Rarc, Tabares-Seisdedos, R, Tovani-Palone, Mr, Vasankari, Tj, Wang, Yz, Zastrozhin, M, Bill & Melinda Gates Foundation, Clinicum, University of Helsinki, HUS Neurocenter, Neurologian yksikkö, Public Health, Tampere University, Health Sciences, and Clinical Medicine
Subjects: Science & Technology, Injuries, DEATHS, Public Health, Environmental and Occupational Health, Burden of disease, Public Health, Global Health, Social Medicine and Epidemiology, 3121 Internal medicine, Disability adjusted life years, Mortality, Europe, 3142 Public health care science, environmental and occupational health, 1117 Public Health and Health Services, Injurie, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, SDG 3 - Good Health and Well-being, INEQUALITIES, Public Health, Human medicine, Disability adjusted life year, Life Sciences & Biomedicine, Public, Environmental & Occupational Health
Abstract: Background Injury remains a major concern to public health in the European region. Previous iterations of the Global Burden of Disease (GBD) study showed wide variation in injury death and disability adjusted life year (DALY) rates across Europe, indicating injury inequality gaps between sub-regions and countries. The objectives of this study were to: 1) compare GBD 2019 estimates on injury mortality and DALYs across European sub-regions and countries by cause-of-injury category and sex; 2) examine changes in injury DALY rates over a 20 year-period by cause-of-injury category, sub-region and country; and 3) assess inequalities in injury mortality and DALY rates across the countries. Methods We performed a secondary database descriptive study using the GBD 2019 results on injuries in 44 European countries from 2000 to 2019. Inequality in DALY rates between these countries was assessed by calculating the DALY rate ratio between the highest-ranking country and lowest-ranking country in each year. Results In 2019, in Eastern Europe 80 [95% uncertainty interval (UI): 71 to 89] people per 100,000 died from injuries; twice as high compared to Central Europe (38 injury deaths per 100,000; 95% UI 34 to 42) and three times as high compared to Western Europe (27 injury deaths per 100,000; 95%UI 25 to 28). The injury DALY rates showed less pronounced differences between Eastern (5129 DALYs per 100,000; 95% UI: 4547 to 5864), Central (2940 DALYs per 100,000; 95% UI: 2452 to 3546) and Western Europe (1782 DALYs per 100,000; 95% UI: 1523 to 2115). Injury DALY rate was lowest in Italy (1489 DALYs per 100,000) and highest in Ukraine (5553 DALYs per 100,000). The difference in injury DALY rates by country was larger for males compared to females. The DALY rate ratio was highest in 2005, with DALY rate in the lowest-ranking country (Russian Federation) 6.0 times higher compared to the highest-ranking country (Malta). After 2005, the DALY rate ratio between the lowest- and the highest-ranking country gradually decreased to 3.7 in 2019. Conclusions Injury mortality and DALY rates were highest in Eastern Europe and lowest in Western Europe, although differences in injury DALY rates declined rapidly, particularly in the past decade. The injury DALY rate ratio of highest- and lowest-ranking country declined from 2005 onwards, indicating declining inequalities in injuries between European countries.
Published: 2022

19. Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Brittney S Sheena, Lindsey Hiebert, Hannah Han, Helen Ippolito, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Amir Abdoli, Hiwa Abubaker Ali, Mesafint Molla Adane, Oyelola A Adegboye, Qorinah Estiningtyas Sakilah Adnani, Shailesh M Advani, Muhammad Sohail Afzal, Saira Afzal, Mohamad Aghaie Meybodi, Bahman Ahadinezhad, Bright Opoku Ahinkorah, Sajjad Ahmad, Tauseef Ahmad, Sepideh Ahmadi, Haroon Ahmed, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Gizachew Taddesse Akalu, Addis Aklilu, Tayyaba Akram, Hanadi Al Hamad, Fares Alahdab, Adugnaw Zeleke Alem, Dejene Tsegaye Alem, Fadwa Alhalaiqa Naji Alhalaiqa, Robert Kaba Alhassan, Liaqat Ali, Muhammad Ashar Ali, Yousef Alimohamadi, Vahid Alipour, Motasem Alkhayyat, Sami Almustanyir, Rajaa M Al-Raddadi, Haya Altawalah, Saeed Amini, Hubert Amu, Robert Ancuceanu, Catalina Liliana Andrei, Tudorel Andrei, Amir Anoushiravani, Adnan Ansar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Ayele Mamo Argaw, Zeleke Gebru Argaw, Muhammad Arshad, Anton A Artamonov, Tahira Ashraf, Daniel Atlaw, Floriane Ausloos, Marcel Ausloos, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ghasem Azarian, Sayna Bagheri, Saeed Bahadory, Atif Amin Baig, Maciej Banach, Nastaran Barati, Amadou Barrow, Abdul-Monim Mohammad Batiha, Diana Fernanda Bejarano Ramirez, Uzma Iqbal Belgaumi, Alemshet Yirga Berhie, Devidas S Bhagat, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Ali Bijani, Antonio Biondi, Belay Boda Abule Bodicha, Hunduma Amensisa Bojia, Archith Boloor, Cristina Bosetti, Dejana Braithwaite, Nikolay Ivanovich Briko, Zahid A Butt, Luis Alberto Cámera, Raja Chandra Chakinala, Promit Ananyo Chakraborty, Jaykaran Charan, Shu Chen, Jee-Young Jasmine Choi, Sonali Gajanan Choudhari, Fazle Rabbi Chowdhury, Dinh-Toi Chu, Sheng-Chia Chung, Paolo Angelo Cortesi, Benjamin C Cowie, Garland T Culbreth, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Fernando Pio De la Hoz, Sisay Abebe Debela, Mohammed Gebre Dedefo, Feleke Mekonnen Demeke, Takele Gezahegn G Demie, Getu Debalkie Demissie, Meseret Derbew Molla, Abebaw Alemayehu Desta, Deepak Dhamnetiya, Mandira Lamichhane Dhimal, Meghnath Dhimal, Mojtaba Didehdar, Linh Phuong Doan, Fariba Dorostkar, Thomas M Drake, Fatemeh Eghbalian, Michael Ekholuenetale, Iman El Sayed, Maysaa El Sayed Zaki, Muhammed Elhadi, Mohamed A Elmonem, Aisha Elsharkawy, Shymaa Enany, Daniel Berhanie Enyew, Ryenchindorj Erkhembayar, Sharareh Eskandarieh, Firooz Esmaeilzadeh, Sayeh Ezzikouri, Hossein Farrokhpour, Getahun Fetensa, Florian Fischer, Masoud Foroutan, Mohamed M Gad, Abhay Motiramji Gaidhane, Shilpa Gaidhane, Natalie C Galles, Silvano Gallus, Teferi Gebru Gebremeskel, Eyob Alemayehu Gebreyohannes, Keyghobad Ghadiri, Kazem Ghaffari, Mansour Ghafourifard, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Ali Gholami, Abdolmajid Gholizadeh, Aima Gilani, Amit Goel, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Giuseppe Gorini, Yitayal Ayalew Goshu, Max G Griswold, Mohammed Ibrahim Mohialdeen Gubari, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Rabih Halwani, Saeed S Hamid, Samer Hamidi, Asif Hanif, Shafiul Haque, Harapan Harapan, Arief Hargono, Sanam Hariri, Ahmed I Hasaballah, S M Mahmudul Hasan, Soheil Hassanipour, Hadi Hassankhani, Simon I Hay, Khezar Hayat, Golnaz Heidari, Claudiu Herteliu, Demisu Zenbaba Heyi, Kamal Hezam, Ramesh Holla, Mohammad-Salar Hosseini, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Mowafa Househ, Junjie Huang, Nawfal R Hussein, Ivo Iavicoli, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Lalu Muhammad Irham, Jessica Y Islam, Nahlah Elkudssiah Ismail, Kathryn H Jacobsen, Farhad Jadidi-Niaragh, Amirreza Javadi Mamaghani, Shubha Jayaram, Ranil Jayawardena, Rime Jebai, Ravi Prakash Jha, Nitin Joseph, Farahnaz Joukar, Billingsley Kaambwa, Ali Kabir, Zubair Kabir, Rohollah Kalhor, Himal Kandel, Tesfaye K Tesfaye Kanko, Rami S Kantar, Ibraheem M Karaye, Bekalu Getnet Kassa, Phillip M Kemp Bohan, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Gulfaraz Khan, Imteyaz A Khan, Junaid Khan, Moien AB Khan, Javad Khanali, Amir M Khater, Mahalaqua Nazli Khatib, Mahmoud Khodadost, Abdullah T Khoja, Omid Khosravizadeh, Jagdish Khubchandani, Gyu Ri Kim, Hanna Kim, Min Seo Kim, Yun Jin Kim, Jonathan M Kocarnik, Ali-Asghar Kolahi, Rajasekaran Koteeswaran, G Anil Kumar, Carlo La Vecchia, Dharmesh Kumar Lal, Iván Landires, Savita Lasrado, Jeffrey V Lazarus, Caterina Ledda, Doo Woong Lee, Sang-woong Lee, Yeong Yeh Lee, Miriam Levi, Jiarui Li, Stephen S Lim, Stany W Lobo, Platon D Lopukhov, Joana A Loureiro, Jennifer H MacLachlan, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Azeem Majeed, Alaa Makki, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Fariborz Mansour-Ghanaei, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Philippa C Matthews, Walter Mendoza, Ritesh G Menezes, Tuomo J Meretoja, Amanual Getnet Mersha, Tomislav Mestrovic, Ted R Miller, Le Huu Nhat Minh, Andreea Mirica, Seyyedmohammadsadeq Mirmoeeni, Erkin M Mirrakhimov, Sanjeev Misra, Prasanna Mithra, Babak Moazen, Ashraf Mohamadkhani, Mokhtar Mohammadi, Shafiu Mohammed, Nagabhishek Moka, Ali H Mokdad, Jalal Moludi, Sara Momtazmanesh, Lorenzo Monasta, Ghobad Moradi, Maliheh Moradzadeh, Rahmatollah Moradzadeh, Paula Moraga, Ebrahim Mostafavi, Sumaira Mubarik, Malaisamy Muniyandi, Christopher J L Murray, Mohsen Naghavi, Mukhammad David Naimzada, Sreenivas Narasimha Swamy, Zuhair S Natto, Biswa Prakash Nayak, Javad Nazari, Ionut Negoi, Serban Mircea Negru, Seyed Aria Nejadghaderi, Sandhya Neupane Kandel, Huong Lan Thi Nguyen, Che Henry Ngwa, Robina Khan Niazi, Chukwudi A Nnaji, Jean Jacques Noubiap, Ali Nowroozi, Virginia Nuñez-Samudio, Bogdan Oancea, Chimedsuren Ochir, Oluwakemi Ololade Odukoya, In-Hwan Oh, Andrew T Olagunju, Babayemi Oluwaseun Olakunde, Ahmed Omar Bali, Emad Omer, Stanislav S Otstavnov, Bilcha Oumer, Jagadish Rao Padubidri, Adrian Pana, Anamika Pandey, Eun-Cheol Park, Fatemeh Pashazadeh Kan, Urvish K Patel, Uttam Paudel, Ionela-Roxana Petcu, Zahra Zahid Piracha, Richard Charles G Pollok, Maarten J Postma, Akram Pourshams, Hossein Poustchi, Mohammad Rabiee, Navid Rabiee, Alireza Rafiei, Sima Rafiei, Pavan Manibettu Raghuram, Mosiur Rahman, Amir Masoud Rahmani, Setyaningrum Rahmawaty, Aashish Rajesh, Priyanga Ranasinghe, Chythra R Rao, Sowmya J Rao, Mahsa Rashidi, Mohammad-Mahdi Rashidi, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Negar Rezaei, Aziz Rezapour, Sahba Rezazadeh-Khadem, Jefferson Antonio Buendia Rodriguez, Godfrey M Rwegerera, Siamak Sabour, Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Amirhossein Sahebkar, KM Saif-Ur-Rahman, Sarvenaz Salahi, Hamideh Salimzadeh, Chethan Sampath, Abdallah M Samy, Juan Sanabria, Francesco Sanmarchi, Milena M Santric-Milicevic, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Abdul-Aziz Seidu, Sadaf G Sepanlou, Allen Seylani, Saeed Shahabi, Masood Ali Shaikh, Elaheh Shaker, Murad Ziyaudinovich Shakhmardanov, Mohammed Shannawaz, Suchitra M Shenoy, Jeevan K Shetty, Pavanchand H Shetty, Kenji Shibuya, Jae Il Shin, Parnian Shobeiri, Migbar Mekonnen Sibhat, Achintya Dinesh Singh, Jasvinder A Singh, Surjit Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Amir Ali Sohrabpour, Suhang Song, Seidamir Pasha Tabaeian, Eyayou Girma Tadesse, Majid Taheri, Mircea Tampa, Ker-Kan Tan, Ahmad Tavakoli, Abdelghani Tbakhi, Belay Negash Tefera, Arash Tehrani-Banihashemi, Habtamu Molla Tesfaw, Rekha Thapar, Aravind Thavamani, Seyed Abolfazl Tohidast, Daniel Nigusse Tollosa, Maria Elena Tosti, Marcos Roberto Tovani-Palone, Eugenio Traini, Mai Thi Ngoc Tran, Indang Trihandini, Biruk Shalmeno Tusa, Irfan Ullah, Marco Vacante, Sahel Valadan Tahbaz, Pascual R Valdez, Shoban Babu Varthya, Bay Vo, Yasir Waheed, Adisu Birhanu Weldesenbet, Melat 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S., Hiebert, L., Han, H., Ippolito, H., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abbastabar, H., Abdoli, A., Abubaker Ali, H., Adane, M. M., Adegboye, O. A., Adnani, Q. E. S., Advani, S. M., Afzal, M. S., Afzal, S., Aghaie Meybodi, M., Ahadinezhad, B., Ahinkorah, B. O., Ahmad, S., Ahmad, T., Ahmadi, S., Ahmed, H., Ahmed, M. B., Rashid, T. A., Akalu, G. T., Aklilu, A., Akram, T., Al Hamad, H., Alahdab, F., Alem, A., Alem, D. T., Alhalaiqa, F. A. N., Alhassan, R. K., Ali, L., Ali, M. A., Alimohamadi, Y., Alipour, V., Alkhayyat, M., Almustanyir, S., Al-Raddadi, R. M., Altawalah, H., Amini, S., Amu, H., Ancuceanu, R., Andrei, C. L., Andrei, T., Anoushiravani, A., Ansar, A., Anyasodor, A. E., Arabloo, J., Arab-Zozani, M., Argaw, A. M., Argaw, Z. G., Arshad, M., Artamonov, A. A., Ashraf, T., Atlaw, D., Ausloos, F., Ausloos, M., Azadnajafabad, S., Azangou-Khyavy, M., Azari Jafari, A., Azarian, G., Bagheri, S., Bahadory, S., Baig, A. A., Banach, M., Barati, N., Barrow, A., Batiha, A. -M. M., Bejarano Ramirez, D. F., Belgaumi, U. I., Berhie, A. Y., Bhagat, D. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bhojaraja, V. S., Bijani, A., Biondi, A., Bodicha, B. B. A., Bojia, H. A., Boloor, A., Bosetti, C., Braithwaite, D., Briko, N. I., Butt, Z. A., Camera, L. A., Chakinala, R. C., Chakraborty, P. A., Charan, J., Chen, S., Choi, J. -Y. J., Choudhari, S. G., Chowdhury, F. R., Chu, D. -T., Chung, S. -C., Cortesi, P. A., Cowie, B. C., Culbreth, G. T., Dadras, O., Dai, X., Dandona, L., Dandona, R., De La Hoz, F. P., Debela, S. A., Dedefo, M. G., Demeke, F. M., Demie, T. G. G., Demissie, G. D., Derbew Molla, M., Desta, A. A., Dhamnetiya, D., Dhimal, M. L., Dhimal, M., Didehdar, M., Doan, L. P., Dorostkar, F., Drake, T. M., Eghbalian, F., Ekholuenetale, M., El Sayed, I., El Sayed Zaki, M., Elhadi, M., Elmonem, M. A., Elsharkawy, A., Enany, S., Enyew, D. B., Erkhembayar, R., Eskandarieh, S., Esmaeilzadeh, F., Ezzikouri, S., Farrokhpour, H., Fetensa, G., Fischer, F., Foroutan, M., Gad, M. M., Gaidhane, A. M., Gaidhane, S., Galles, N. C., Gallus, S., Gebremeskel, T. G., Gebreyohannes, E. A., Ghadiri, K., Ghaffari, K., Ghafourifard, M., Ghamari, S. -H., Ghashghaee, A., Gholami, A., Gholizadeh, A., Gilani, A., Goel, A., Golechha, M., Goleij, P., Golinelli, D., Gorini, G., Goshu, Y. A., Griswold, M. G., Gubari, M. I. M., Gupta, B., Gupta, S., Gupta, V. B., Gupta, V. K., Haddadi, R., Halwani, R., Hamid, S. S., Hamidi, S., Hanif, A., Haque, S., Harapan, H., Hargono, A., Hariri, S., Hasaballah, A. I., Hasan, S. M. M., Hassanipour, S., Hassankhani, H., Hay, S. I., Hayat, K., Heidari, G., Herteliu, C., Heyi, D. Z., Hezam, K., Holla, R., Hosseini, M. -S., Hosseini, M., Hosseinzadeh, M., Hostiuc, M., Househ, M., Huang, J., Hussein, N. R., Iavicoli, I., Ibitoye, S. E., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Irham, L. M., Islam, J. Y., Ismail, N. E., Jacobsen, K. H., Jadidi-Niaragh, F., Javadi Mamaghani, A., Jayaram, S., Jayawardena, R., Jebai, R., Jha, R. P., Joseph, N., Joukar, F., Kaambwa, B., Kabir, A., Kabir, Z., Kalhor, R., Kandel, H., Kanko, T. K. T., Kantar, R. S., Karaye, I. M., Kassa, B. G., Kemp Bohan, P. M., Keykhaei, M., Khader, Y. S., Khajuria, H., Khan, G., Khan, I. A., Khan, J., Khan, M. A., Khanali, J., Khater, A. M., Khatib, M. N., Khodadost, M., Khoja, A. T., Khosravizadeh, O., Khubchandani, J., Kim, G. R., Kim, H., Kim, M. S., Kim, Y. J., Kocarnik, J. M., Kolahi, A. -A., Koteeswaran, R., Kumar, G. A., La Vecchia, C., Lal, D. K., Landires, I., Lasrado, S., Lazarus, J. V., Ledda, C., Lee, D. W., Lee, S. -W., Lee, Y. Y., Levi, M., Li, J., Lim, S. S., Lobo, S. W., Lopukhov, P. D., Loureiro, J. A., Maclachlan, J. H., Magdy Abd El Razek, H., Magdy Abd El Razek, M., Majeed, A., Makki, A., Malekpour, M. -R., Malekzadeh, R., Malik, A. A., Mansour-Ghanaei, F., Mansournia, M. A., Martins-Melo, F. R., Matthews, P. C., Mendoza, W., Menezes, R. G., Meretoja, T. J., Mersha, A. G., Mestrovic, T., Miller, T. R., Minh, L. H. N., Mirica, A., Mirmoeeni, S., Mirrakhimov, E. M., Misra, S., Mithra, P., Moazen, B., Mohamadkhani, A., Mohammadi, M., Mohammed, S., Moka, N., Mokdad, A. H., Moludi, J., Momtazmanesh, S., Monasta, L., Moradi, G., Moradzadeh, M., Moradzadeh, R., Moraga, P., Mostafavi, E., Mubarik, S., Muniyandi, M., Murray, C. J. L., Naghavi, M., Naimzada, M. D., Narasimha Swamy, S., Natto, Z. S., Nayak, B. P., Nazari, J., Negoi, I., Negru, S. M., Nejadghaderi, S. A., Neupane Kandel, S., Nguyen, H. L. T., Ngwa, C. H., Niazi, R. K., Nnaji, C. A., Noubiap, J. J., Nowroozi, A., Nunez-Samudio, V., Oancea, B., Ochir, C., Odukoya, O. O., Oh, I. -H., Olagunju, A. T., Olakunde, B. O., Omar Bali, A., Omer, E., Otstavnov, S. S., Oumer, B., Padubidri, J. R., Pana, A., Pandey, A., Park, E. -C., Pashazadeh Kan, F., Patel, U. K., Paudel, U., Petcu, I. -R., Piracha, Z. Z., Pollok, R. C. G., Postma, M. J., Pourshams, A., Poustchi, H., Rabiee, M., Rabiee, N., Rafiei, A., Rafiei, S., Raghuram, P. M., Rahman, M., Rahmani, A. M., Rahmawaty, S., Rajesh, A., Ranasinghe, P., Rao, C. R., Rao, S. J., Rashidi, M., Rashidi, M. -M., Rawaf, D. L., Rawaf, S., Rawassizadeh, R., Rezaei, N., Rezapour, A., Rezazadeh-Khadem, S., Rodriguez, J. A. B., Rwegerera, G. M., Sabour, S., Saddik, B., Saeb, M. R., Saeed, U., Sahebkar, A., Saif-Ur-Rahman, K. M., Salahi, S., Salimzadeh, H., Sampath, C., Samy, A. M., Sanabria, J., Sanmarchi, F., Santric-Milicevic, M. M., Sarveazad, A., Sathian, B., Sawhney, M., Seidu, A. -A., Sepanlou, S. G., Seylani, A., Shahabi, S., Shaikh, M. A., Shaker, E., Shakhmardanov, M. Z., Shannawaz, M., Shenoy, S. M., Shetty, J. K., Shetty, P. H., Shibuya, K., Shin, J. I., Shobeiri, P., Sibhat, M. M., Singh, A. D., Singh, J. A., Singh, S., Skryabin, V. Y., Skryabina, A. A., Sohrabpour, A. A., Song, S., Tabaeian, S. P., Tadesse, E. G., Taheri, M., Tampa, M., Tan, K. -K., Tavakoli, A., Tbakhi, A., Tefera, B. N., Tehrani-Banihashemi, A., Tesfaw, H. M., Thapar, R., Thavamani, A., Tohidast, S. A., Tollosa, D. N., Tosti, M. E., Tovani-Palone, M. R., Traini, E., Tran, M. T. N., Trihandini, I., Tusa, B. S., Ullah, I., Vacante, M., Valadan Tahbaz, S., Valdez, P. R., Varthya, S. B., Vo, B., Waheed, Y., Weldesenbet, A. B., Woldemariam, M., Xu, S., Yahyazadeh Jabbari, S. H., Yaseri, M., Yeshaw, Y., Yigit, V., Yirdaw, B. W., Yonemoto, N., Yu, C., Yunusa, I., Zahir, M., Zaki, L., Zamani, M., Zamanian, M., Zastrozhin, M. S., Vos, T., Ward, J. W., and Dirac, M. A.
Subjects: Liver Cirrhosis, Hepatology, Seroepidemiologic Studies, 3121 General medicine, internal medicine and other clinical medicine, Liver Neoplasms, Gastroenterology, Humans, Bayes Theorem, HBV, Global burden of diseases, HCC, Cirrhosis, Child, Hepatitis B, Global Burden of Disease
Abstract: Publisher Copyright: © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-of-sample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings: In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4·1% (95% uncertainty interval [UI] 3·7 to 4·5), corresponding to 316 million (284 to 351) infected people. There was a 31·3% (29·0 to 33·9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76·8% (76·2 to 77·5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5·9% [–5·6 to 19·2]) and between 2015 and 2019 (by 2·9% [–5·9 to 11·3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation: The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination. Funding: Bill & Melinda Gates Foundation.
Published: 2022

20. Regularities of the heterogeneous catalytic hydrogenation of 5-vinyl-2-norbornene

Author: V. V. Zamalyutin, A. V. Ryabov, A. I. Nichugovskii, A. Yu. Skryabina, O. Yu. Tkachenko, and V. R. Flid
Subjects: General Chemistry
Published: 2022

21. Pharmacokinetics and pharmacogenetics of macrolides (literature review)

Author: A. Skryabina, V. Nikiforov, M. Shakhmardanov, M. Zastrozhin, and D. Sychev
Subjects: General Medicine
Abstract: The aim of this research is to systematize scientific data on the pharmacokinetics and pharmacogenetics of macrolides. Macrolides are a class of broad-spectrum antibiotics used to treat a wide range of both topical and systemic infectious diseases. Despite the fact that macrolide use is generally considered to be safe, in a number of patients it can be associated with dose-dependent adverse drug reactions (ADRs), reducing the safety of therapy in these patients. Knowledge of the peculiarities of pharmacokinetics, pharmacodynamics and pharmacogenetics of macrolides is necessary to assess the effect of genetically determined activity of cytochrome isoenzymes of the P450 system on plasma concentration, efficacy and safety of antibiotics from this group. This will make it possible to develop approaches to personalizing the selection of an effective and safe dose of macrolides based on the clinical and biological parameters of the patient. Results: it was found that genotypic variability affects both the transport of macrolides and their metabolism. It has been shown that polymorphism of a number of candidate genes can affect the pharmacokinetics and pharmacodynamics of macrolides, which may explain the differences in the efficacy and safety of therapy in different patients.
Published: 2022

22. The Art of Domra Playing: From the History of Professional Education

Author: Ekaterina G. Skryabina
Subjects: Developmental and Educational Psychology, Music, Education
Published: 2022

23. Additional file 1 of Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018

Author: Haeuser, Emily, Serfes, Audrey L., Cork, Michael A., Yang, Mingyou, Abbastabar, Hedayat, Abhilash, E. S., Adabi, Maryam, Adebayo, Oladimeji M., Adekanmbi, Victor, Adeyinka, Daniel Adedayo, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmadi, Keivan, Ahmed, Muktar Beshir, Akalu, Yonas, Akinyemi, Rufus Olusola, Akunna, Chisom Joyqueenet, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M., Alene, Kefyalew Addis, Alhassan, Robert Kaba, Alipour, Vahid, Almasi-Hashiani, Amir, Alvis-Guzman, Nelson, Ameyaw, Edward Kwabena, Amini, Saeed, Amugsi, Dickson A., Ancuceanu, Robert, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Aremu, Olatunde, Asemahagn, Mulusew A., Jafarabadi, Mohammad Asghari, Awedew, Atalel Fentahun, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Azari, Samad, Azene, Zelalem Nigussie, Darshan, B. B., Babalola, Tesleem Kayode, Baig, Atif Amin, Banach, Maciej, Bärnighausen, Till Winfried, Bell, Arielle Wilder, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bijani, Ali, Bitew, Zebenay Workneh, Bohlouli, Somayeh, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Bozicevic, Ivana, Butt, Zahid A., Cárdenas, Rosario, Carvalho, Felix, Charan, Jaykaran, Chattu, Vijay Kumar, Chowdhury, Mohiuddin Ahsanul Kabir, Chu, Dinh-Toi, Cowden, Richard G., Dahlawi, Saad M. A., Damiani, Giovanni, Darteh, Eugene Kofuor Maafo, Darwesh, Aso Mohammad, das Neves, José, Weaver, Nicole Davis, De Leo, Diego, De Neve, Jan-Walter, Deribe, Kebede, Deuba, Keshab, Dharmaratne, Samath, Dianatinasab, Mostafa, Diaz, Daniel, Didarloo, Alireza, Djalalinia, Shirin, Dorostkar, Fariba, Dubljanin, Eleonora, Duko, Bereket, El Tantawi, Maha, El-Jaafary, Shaimaa I., Eshrati, Babak, Eskandarieh, Sharareh, Eyawo, Oghenowede, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Farzadfar, Farshad, Fattahi, Nazir, Fauk, Nelsensius Klau, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foigt, Nataliya A., Foroutan, Masoud, Fukumoto, Takeshi, Gad, Mohamed M., Gaidhane, Abhay Motiramji, Gebregiorgis, Birhan Gebresillassie, Gebremedhin, Ketema Bizuwork, Getacher, Lemma, Ghadiri, Keyghobad, Ghashghaee, Ahmad, Golechha, Mahaveer, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Haider, Mohammad Rifat, Haj-Mirzaian, Arvin, Hamidi, Samer, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Hayat, Khezar, Herteliu, Claudiu, Ho, Hung Chak, Holla, Ramesh, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Islam, Rakibul M., Iwu, Chidozie C. D., Jakovljevic, Mihajlo, Jha, Ravi Prakash, Ji, John S., Johnson, Kimberly B., Joseph, Nitin, Joshua, Vasna, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Kalankesh, Leila R., Kalhor, Rohollah, Kamyari, Naser, Kanchan, Tanuj, Matin, Behzad Karami, Karimi, Salah Eddin, Kayode, Gbenga A., Karyani, Ali Kazemi, Keramati, Maryam, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Md Nuruzzaman, Khatab, Khaled, Khubchandani, Jagdish, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kopec, Jacek A., Kosen, Soewarta, Laxminarayana, Sindhura Lakshmi Koulmane, Koyanagi, Ai, Krishan, Kewal, Defo, Barthelemy Kuate, Kugbey, Nuworza, Kulkarni, Vaman, Kumar, Manasi, Kumar, Nithin, Kusuma, Dian, La Vecchia, Carlo, Lal, Dharmesh Kumar, Landires, Iván, Larson, Heidi Jane, Lasrado, Savita, Lee, Paul H., Li, Shanshan, Liu, Xuefeng, Maleki, Afshin, Malik, Preeti, Mansournia, Mohammad Ali, Martins-Melo, Francisco Rogerlândio, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Meretoja, Tuomo J., Mestrovic, Tomislav, Mirica, Andreea, Moazen, Babak, Mohamad, Osama, Mohammad, Yousef, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Salahuddin, Mohammed, Shafiu, Mokdad, Ali H., Moradi, Masoud, Moraga, Paula, Mubarik, Sumaira, Mulu, Getaneh Baye B., Mwanri, Lillian, Nagarajan, Ahamarshan Jayaraman, Naimzada, Mukhammad David, Naveed, Muhammad, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Ngalesoni, Frida N., Nguefack-Tsague, Georges, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nnaji, Chukwudi A., Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nwatah, Vincent Ebuka, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Olagunju, Andrew T., Olakunde, Babayemi Oluwaseun, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Bali, Ahmed Omar, Onwujekwe, Obinna E., Orisakwe, Orish Ebere, Otstavnov, Nikita, Otstavnov, Stanislav S., Owolabi, Mayowa O., Mahesh, P. A., Padubidri, Jagadish Rao, Pana, Adrian, Pandey, Ashok, Pandi-Perumal, Seithikurippu R., Kan, Fatemeh Pashazadeh, Patton, George C., Pawar, Shrikant, Peprah, Emmanuel K., Postma, Maarten J., Preotescu, Liliana, Syed, Zahiruddin Quazi, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahmani, Amir Masoud, Ramezanzadeh, Kiana, Rana, Juwel, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Regassa, Lemma Demissie, Rezaei, Nima, Rezapour, Aziz, Riaz, Mavra A., Ribeiro, Ana Isabel, Ross, Jennifer M., Rubagotti, Enrico, Rumisha, Susan Fred, Rwegerera, Godfrey M., Moghaddam, Sahar Saeedi, Sagar, Rajesh, Sahiledengle, Biniyam, Sahu, Maitreyi, Salem, Marwa Rashad, Kafil, Hossein Samadi, Samy, Abdallah M., Sartorius, Benn, Sathian, Brijesh, Seidu, Abdul-Aziz, Shaheen, Amira A., Shaikh, Masood Ali, Shamsizadeh, Morteza, Shiferaw, Wondimeneh Shibabaw, Shin, Jae Il, Shrestha, Roman, Singh, Jasvinder A., Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani, Shahin, Sufiyan, Mu’awiyyah Babale, Tabuchi, Takahiro, Tadesse, Eyayou Girma, Taveira, Nuno, Tesfay, Fisaha Haile, Thapar, Rekha, Tovani-Palone, Marcos Roberto, Tsegaye, Gebiyaw Wudie, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Villafañe, Jorge Hugo, Violante, Francesco S., Vo, Bay, Vu, Giang Thu, Wado, Yohannes Dibaba, Waheed, Yasir, Wamai, Richard G., Wang, Yanzhong, Ward, Paul, Wickramasinghe, Nuwan Darshana, Wilson, Katherine, Yaya, Sanni, Yip, Paul, Yonemoto, Naohiro, Yu, Chuanhua, Zastrozhin, Mikhail Sergeevich, Zhang, Yunquan, Zhang, Zhi-Jiang, Hay, Simon I., and Dwyer-Lindgren, Laura
Abstract: Additional file 1: Supplemental information.1. Compliance with the Guidlines for Accurate and Transparent Health Estimates Reporting (GATHER). 2. HIV data sources and data processing. 3. Covariate and auxiliary data. 4. Statistical model. 5. References.
Published: 2023
Full Text: View/download PDF

24. Additional file 2 of Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018

Author: Haeuser, Emily, Serfes, Audrey L., Cork, Michael A., Yang, Mingyou, Abbastabar, Hedayat, Abhilash, E. S., Adabi, Maryam, Adebayo, Oladimeji M., Adekanmbi, Victor, Adeyinka, Daniel Adedayo, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmadi, Keivan, Ahmed, Muktar Beshir, Akalu, Yonas, Akinyemi, Rufus Olusola, Akunna, Chisom Joyqueenet, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M., Alene, Kefyalew Addis, Alhassan, Robert Kaba, Alipour, Vahid, Almasi-Hashiani, Amir, Alvis-Guzman, Nelson, Ameyaw, Edward Kwabena, Amini, Saeed, Amugsi, Dickson A., Ancuceanu, Robert, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Aremu, Olatunde, Asemahagn, Mulusew A., Jafarabadi, Mohammad Asghari, Awedew, Atalel Fentahun, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Azari, Samad, Azene, Zelalem Nigussie, Darshan, B. B., Babalola, Tesleem Kayode, Baig, Atif Amin, Banach, Maciej, Bärnighausen, Till Winfried, Bell, Arielle Wilder, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bijani, Ali, Bitew, Zebenay Workneh, Bohlouli, Somayeh, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Bozicevic, Ivana, Butt, Zahid A., Cárdenas, Rosario, Carvalho, Felix, Charan, Jaykaran, Chattu, Vijay Kumar, Chowdhury, Mohiuddin Ahsanul Kabir, Chu, Dinh-Toi, Cowden, Richard G., Dahlawi, Saad M. A., Damiani, Giovanni, Darteh, Eugene Kofuor Maafo, Darwesh, Aso Mohammad, das Neves, José, Weaver, Nicole Davis, De Leo, Diego, De Neve, Jan-Walter, Deribe, Kebede, Deuba, Keshab, Dharmaratne, Samath, Dianatinasab, Mostafa, Diaz, Daniel, Didarloo, Alireza, Djalalinia, Shirin, Dorostkar, Fariba, Dubljanin, Eleonora, Duko, Bereket, El Tantawi, Maha, El-Jaafary, Shaimaa I., Eshrati, Babak, Eskandarieh, Sharareh, Eyawo, Oghenowede, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Farzadfar, Farshad, Fattahi, Nazir, Fauk, Nelsensius Klau, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foigt, Nataliya A., Foroutan, Masoud, Fukumoto, Takeshi, Gad, Mohamed M., Gaidhane, Abhay Motiramji, Gebregiorgis, Birhan Gebresillassie, Gebremedhin, Ketema Bizuwork, Getacher, Lemma, Ghadiri, Keyghobad, Ghashghaee, Ahmad, Golechha, Mahaveer, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Haider, Mohammad Rifat, Haj-Mirzaian, Arvin, Hamidi, Samer, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Hayat, Khezar, Herteliu, Claudiu, Ho, Hung Chak, Holla, Ramesh, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Islam, Rakibul M., Iwu, Chidozie C. D., Jakovljevic, Mihajlo, Jha, Ravi Prakash, Ji, John S., Johnson, Kimberly B., Joseph, Nitin, Joshua, Vasna, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Kalankesh, Leila R., Kalhor, Rohollah, Kamyari, Naser, Kanchan, Tanuj, Matin, Behzad Karami, Karimi, Salah Eddin, Kayode, Gbenga A., Karyani, Ali Kazemi, Keramati, Maryam, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Md Nuruzzaman, Khatab, Khaled, Khubchandani, Jagdish, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kopec, Jacek A., Kosen, Soewarta, Laxminarayana, Sindhura Lakshmi Koulmane, Koyanagi, Ai, Krishan, Kewal, Defo, Barthelemy Kuate, Kugbey, Nuworza, Kulkarni, Vaman, Kumar, Manasi, Kumar, Nithin, Kusuma, Dian, La Vecchia, Carlo, Lal, Dharmesh Kumar, Landires, Iván, Larson, Heidi Jane, Lasrado, Savita, Lee, Paul H., Li, Shanshan, Liu, Xuefeng, Maleki, Afshin, Malik, Preeti, Mansournia, Mohammad Ali, Martins-Melo, Francisco Rogerlândio, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Meretoja, Tuomo J., Mestrovic, Tomislav, Mirica, Andreea, Moazen, Babak, Mohamad, Osama, Mohammad, Yousef, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Salahuddin, Mohammed, Shafiu, Mokdad, Ali H., Moradi, Masoud, Moraga, Paula, Mubarik, Sumaira, Mulu, Getaneh Baye B., Mwanri, Lillian, Nagarajan, Ahamarshan Jayaraman, Naimzada, Mukhammad David, Naveed, Muhammad, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Ngalesoni, Frida N., Nguefack-Tsague, Georges, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nnaji, Chukwudi A., Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nwatah, Vincent Ebuka, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Olagunju, Andrew T., Olakunde, Babayemi Oluwaseun, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Bali, Ahmed Omar, Onwujekwe, Obinna E., Orisakwe, Orish Ebere, Otstavnov, Nikita, Otstavnov, Stanislav S., Owolabi, Mayowa O., Mahesh, P. A., Padubidri, Jagadish Rao, Pana, Adrian, Pandey, Ashok, Pandi-Perumal, Seithikurippu R., Kan, Fatemeh Pashazadeh, Patton, George C., Pawar, Shrikant, Peprah, Emmanuel K., Postma, Maarten J., Preotescu, Liliana, Syed, Zahiruddin Quazi, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahmani, Amir Masoud, Ramezanzadeh, Kiana, Rana, Juwel, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Regassa, Lemma Demissie, Rezaei, Nima, Rezapour, Aziz, Riaz, Mavra A., Ribeiro, Ana Isabel, Ross, Jennifer M., Rubagotti, Enrico, Rumisha, Susan Fred, Rwegerera, Godfrey M., Moghaddam, Sahar Saeedi, Sagar, Rajesh, Sahiledengle, Biniyam, Sahu, Maitreyi, Salem, Marwa Rashad, Kafil, Hossein Samadi, Samy, Abdallah M., Sartorius, Benn, Sathian, Brijesh, Seidu, Abdul-Aziz, Shaheen, Amira A., Shaikh, Masood Ali, Shamsizadeh, Morteza, Shiferaw, Wondimeneh Shibabaw, Shin, Jae Il, Shrestha, Roman, Singh, Jasvinder A., Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani, Shahin, Sufiyan, Mu’awiyyah Babale, Tabuchi, Takahiro, Tadesse, Eyayou Girma, Taveira, Nuno, Tesfay, Fisaha Haile, Thapar, Rekha, Tovani-Palone, Marcos Roberto, Tsegaye, Gebiyaw Wudie, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Villafañe, Jorge Hugo, Violante, Francesco S., Vo, Bay, Vu, Giang Thu, Wado, Yohannes Dibaba, Waheed, Yasir, Wamai, Richard G., Wang, Yanzhong, Ward, Paul, Wickramasinghe, Nuwan Darshana, Wilson, Katherine, Yaya, Sanni, Yip, Paul, Yonemoto, Naohiro, Yu, Chuanhua, Zastrozhin, Mikhail Sergeevich, Zhang, Yunquan, Zhang, Zhi-Jiang, Hay, Simon I., and Dwyer-Lindgren, Laura
Abstract: Additional file 2: Supplemental tables.Table S1. HIV seroprevalence survey data. Table S2. ANC sentinel surveillance data. Table S3. HIV and covariates surveys excluded from this analysis. Table S4. Sources for pre-existing covariates. Table S5. HIV covariate survey data. Table S6. Fitted model parameters.
Published: 2023
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25. Additional file 3 of Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018

Author: Haeuser, Emily, Serfes, Audrey L., Cork, Michael A., Yang, Mingyou, Abbastabar, Hedayat, Abhilash, E. S., Adabi, Maryam, Adebayo, Oladimeji M., Adekanmbi, Victor, Adeyinka, Daniel Adedayo, Afzal, Saira, Ahinkorah, Bright Opoku, Ahmadi, Keivan, Ahmed, Muktar Beshir, Akalu, Yonas, Akinyemi, Rufus Olusola, Akunna, Chisom Joyqueenet, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M., Alene, Kefyalew Addis, Alhassan, Robert Kaba, Alipour, Vahid, Almasi-Hashiani, Amir, Alvis-Guzman, Nelson, Ameyaw, Edward Kwabena, Amini, Saeed, Amugsi, Dickson A., Ancuceanu, Robert, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Aremu, Olatunde, Asemahagn, Mulusew A., Jafarabadi, Mohammad Asghari, Awedew, Atalel Fentahun, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Aynalem, Yared Asmare, Azari, Samad, Azene, Zelalem Nigussie, Darshan, B. B., Babalola, Tesleem Kayode, Baig, Atif Amin, Banach, Maciej, Bärnighausen, Till Winfried, Bell, Arielle Wilder, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhattacharyya, Krittika, Bijani, Ali, Bitew, Zebenay Workneh, Bohlouli, Somayeh, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Bozicevic, Ivana, Butt, Zahid A., Cárdenas, Rosario, Carvalho, Felix, Charan, Jaykaran, Chattu, Vijay Kumar, Chowdhury, Mohiuddin Ahsanul Kabir, Chu, Dinh-Toi, Cowden, Richard G., Dahlawi, Saad M. A., Damiani, Giovanni, Darteh, Eugene Kofuor Maafo, Darwesh, Aso Mohammad, das Neves, José, Weaver, Nicole Davis, De Leo, Diego, De Neve, Jan-Walter, Deribe, Kebede, Deuba, Keshab, Dharmaratne, Samath, Dianatinasab, Mostafa, Diaz, Daniel, Didarloo, Alireza, Djalalinia, Shirin, Dorostkar, Fariba, Dubljanin, Eleonora, Duko, Bereket, El Tantawi, Maha, El-Jaafary, Shaimaa I., Eshrati, Babak, Eskandarieh, Sharareh, Eyawo, Oghenowede, Ezeonwumelu, Ifeanyi Jude, Ezzikouri, Sayeh, Farzadfar, Farshad, Fattahi, Nazir, Fauk, Nelsensius Klau, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foigt, Nataliya A., Foroutan, Masoud, Fukumoto, Takeshi, Gad, Mohamed M., Gaidhane, Abhay Motiramji, Gebregiorgis, Birhan Gebresillassie, Gebremedhin, Ketema Bizuwork, Getacher, Lemma, Ghadiri, Keyghobad, Ghashghaee, Ahmad, Golechha, Mahaveer, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Haider, Mohammad Rifat, Haj-Mirzaian, Arvin, Hamidi, Samer, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Hayat, Khezar, Herteliu, Claudiu, Ho, Hung Chak, Holla, Ramesh, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Islam, Rakibul M., Iwu, Chidozie C. D., Jakovljevic, Mihajlo, Jha, Ravi Prakash, Ji, John S., Johnson, Kimberly B., Joseph, Nitin, Joshua, Vasna, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Kalankesh, Leila R., Kalhor, Rohollah, Kamyari, Naser, Kanchan, Tanuj, Matin, Behzad Karami, Karimi, Salah Eddin, Kayode, Gbenga A., Karyani, Ali Kazemi, Keramati, Maryam, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Md Nuruzzaman, Khatab, Khaled, Khubchandani, Jagdish, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kopec, Jacek A., Kosen, Soewarta, Laxminarayana, Sindhura Lakshmi Koulmane, Koyanagi, Ai, Krishan, Kewal, Defo, Barthelemy Kuate, Kugbey, Nuworza, Kulkarni, Vaman, Kumar, Manasi, Kumar, Nithin, Kusuma, Dian, La Vecchia, Carlo, Lal, Dharmesh Kumar, Landires, Iván, Larson, Heidi Jane, Lasrado, Savita, Lee, Paul H., Li, Shanshan, Liu, Xuefeng, Maleki, Afshin, Malik, Preeti, Mansournia, Mohammad Ali, Martins-Melo, Francisco Rogerlândio, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Meretoja, Tuomo J., Mestrovic, Tomislav, Mirica, Andreea, Moazen, Babak, Mohamad, Osama, Mohammad, Yousef, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Salahuddin, Mohammed, Shafiu, Mokdad, Ali H., Moradi, Masoud, Moraga, Paula, Mubarik, Sumaira, Mulu, Getaneh Baye B., Mwanri, Lillian, Nagarajan, Ahamarshan Jayaraman, Naimzada, Mukhammad David, Naveed, Muhammad, Nazari, Javad, Ndejjo, Rawlance, Negoi, Ionut, Ngalesoni, Frida N., Nguefack-Tsague, Georges, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nnaji, Chukwudi A., Noubiap, Jean Jacques, Nuñez-Samudio, Virginia, Nwatah, Vincent Ebuka, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Olagunju, Andrew T., Olakunde, Babayemi Oluwaseun, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Bali, Ahmed Omar, Onwujekwe, Obinna E., Orisakwe, Orish Ebere, Otstavnov, Nikita, Otstavnov, Stanislav S., Owolabi, Mayowa O., Mahesh, P. A., Padubidri, Jagadish Rao, Pana, Adrian, Pandey, Ashok, Pandi-Perumal, Seithikurippu R., Kan, Fatemeh Pashazadeh, Patton, George C., Pawar, Shrikant, Peprah, Emmanuel K., Postma, Maarten J., Preotescu, Liliana, Syed, Zahiruddin Quazi, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahmani, Amir Masoud, Ramezanzadeh, Kiana, Rana, Juwel, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Regassa, Lemma Demissie, Rezaei, Nima, Rezapour, Aziz, Riaz, Mavra A., Ribeiro, Ana Isabel, Ross, Jennifer M., Rubagotti, Enrico, Rumisha, Susan Fred, Rwegerera, Godfrey M., Moghaddam, Sahar Saeedi, Sagar, Rajesh, Sahiledengle, Biniyam, Sahu, Maitreyi, Salem, Marwa Rashad, Kafil, Hossein Samadi, Samy, Abdallah M., Sartorius, Benn, Sathian, Brijesh, Seidu, Abdul-Aziz, Shaheen, Amira A., Shaikh, Masood Ali, Shamsizadeh, Morteza, Shiferaw, Wondimeneh Shibabaw, Shin, Jae Il, Shrestha, Roman, Singh, Jasvinder A., Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Soltani, Shahin, Sufiyan, Mu’awiyyah Babale, Tabuchi, Takahiro, Tadesse, Eyayou Girma, Taveira, Nuno, Tesfay, Fisaha Haile, Thapar, Rekha, Tovani-Palone, Marcos Roberto, Tsegaye, Gebiyaw Wudie, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Villafañe, Jorge Hugo, Violante, Francesco S., Vo, Bay, Vu, Giang Thu, Wado, Yohannes Dibaba, Waheed, Yasir, Wamai, Richard G., Wang, Yanzhong, Ward, Paul, Wickramasinghe, Nuwan Darshana, Wilson, Katherine, Yaya, Sanni, Yip, Paul, Yonemoto, Naohiro, Yu, Chuanhua, Zastrozhin, Mikhail Sergeevich, Zhang, Yunquan, Zhang, Zhi-Jiang, Hay, Simon I., and Dwyer-Lindgren, Laura
Abstract: Additional file 3: Supplemental figures.Figure S1. Prevalence of male circumcision. Figure S2. Prevalence of signs and symptoms of sexually transmitted infections. Figure S3. Prevalence of marriage or living as married. Figure S4. Prevalence of partner living elsewhere among females. Figure S5. Prevalence of condom use during most recent sexual encounter. Figure S6. Prevalence of sexual activity among young females. Figure S7. Prevalence of multiple partners among males in the past year. Figure S8. Prevalence of multiple partners among females in the past year. Figure S9. HIV prevalence predictions from the boosted regression tree model. Figure S10. HIV prevalence predictions from the generalized additive model. Figure S11. HIV prevalence predictions from the lasso regression model. Figure S12. Modeling regions. Figure S13. Age- and sex-specific vs. adult prevalence modeling. Figure S14. Data sensitivity. Figure S15. Model specification validation. Figure S16. Modeled and re-aggregated adult prevalence comparison. Figure S17. HIV prevalence raking factors for males. Figure S18. HIV prevalence raking factors for females. Figure S19. Age-specific HIV prevalence in males, 2000. Figure S20. Age-specific HIV prevalence in females, 2000. Figure S21. Age-specific HIV prevalence in males, 2005. Figure S22. Age-specific HIV prevalence in females, 2005. Figure S23. Age-specific HIV prevalence in males, 2010. Figure S24. Age-specific HIV prevalence in females, 2010. Figure S25. Age-specific HIV prevalence in males, 2018. Figure S26. Age-specific HIV prevalence in females, 2018. Figure S27. Age-specific uncertainty interval range estimates in males, 2000. Figure S28. Age-specific uncertainty interval range estimates in females, 2000. Figure S29. Age-specific uncertainty interval range estimates in males, 2005. Figure S30. Age-specific uncertainty interval range estimates in females, 2005. Figure S31. Age-specific uncertainty interval range estimates in males, 2010. Figure S32. Age-specific uncertainty interval range estimates in females, 2010. Figure S33. Age-specific uncertainty interval range estimates in males, 2018. Figure S34. Age-specific uncertainty interval range estimates in females, 2018. Figure S35. Change in HIV prevalence in males, 2000-2005. Figure S36. Change in HIV prevalence in females, 2000-2005. Figure S37. Change in HIV prevalence in males, 2005-2010. Figure S38. Change in HIV prevalence in females, 2005-2010. Figure S39. Change in HIV prevalence in males, 2010-2018. Figure S40. Change in HIV prevalence in females, 2010-2018. Figure S41. Space mesh for geostatistical models.
Published: 2023
Full Text: View/download PDF

26. Importance of thermal conductivity and stress level during a phase (hydride) transformation in magnesium

Author: V. N Aptukov, I. I. Tsirulnik, N. E Skryabina, and D. Fruchart
Subjects: Mechanics of Materials, Materials Science (miscellaneous), Computational Mechanics
Abstract: There are many different systems of an autonomous energy storage including accumulators and storage devices for renewable energy. Systems based on reversible metal hydrogenation have recently been introduced. The selection of metals is based on considerations of temperature and pressure conditions of the hydrogenation/dehydrogenation cycle, as well as the desired storage hydrogen capacity. Magnesium is one of the main challenging metals with respect to these main conditions since having a hydrogen capacity up to 7.6 w.%. For Mg forming MgH2, it was soon established that the size of particles plays a critical role since the kinetics (rate) of hydride formation accelerates when the size of the particles decreases. The present study shows that the overall diameter of the particles is the main characteristic controlling the kinetics of hydride formation because of distinct issues. A distribution of the size entails a strong dispersion transferring the heat of reaction, which characterizes Mg to MgH2 phase transition. Moreover, the formation of MgH2, is accompanied by a great increase of the unit-cell volume, developing noticeable internal stresses within the surface layers of the particles, thus turning to a systematic flaking and a systematic decrease of sizes of the powder particles. The results of the numerical modeling comply with the experimental data. This makes it possible to predict the best size of the initial Mg powder able to achieve fast kinetics during hydrogenation. Furthermore, the present analysis demonstrates the best hydrogenation kinetics, not only when using fine powders, but also when the deviation from the average particle size is minimized.
Published: 2021

27. TEXT AS A BASIS FOR LEARNING WRITTEN CONNECTED SPEECH AND SPELLING

Author: Alevtina D. Deykina and Olga A. Skryabina
Subjects: ComputingMilieux_COMPUTERSANDEDUCATION, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, General Medicine
Abstract: The article deals with the relevant methodological problem of the interdependence of the processes of teaching connected written speech and spelling based on the text as a didactic unit. The object of the research is the process of teaching schoolchildren the text as a product of speech activity, speech and text skills, the subject is the theoretical and practical development of methods for teaching text as the basis for the formation of text-forming (speech and text) skills in conjunction with text-forming (spelling) skills. The goals and objectives of the article include: firstly, the analysis of theoretical aspects related to the approaches to teaching schoolchildren the text as a product of speech activity and spelling as a structurally and functionally significant component of the written text, with the help of which communicative intention is realized; secondly, the identification of trends in the formation of the text-forming skills (speech and spelling); thirdly, the search for technologies to optimize the learning outcomes of working with text in conjunction with teaching spelling in a modern school. It is proved that the formation of text and spelling skills is more effective on the basis of the text, in a single process of text formation and text formatting, in the aggregate and interdependence of speech and spelling actions. The organization of the educational process is illustrated with exercises and tasks that integrate two areas of work on the text: speech and spelling.
Published: 2021

28. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study

Author: Bourne R. R. A., Steinmetz J. D., Saylan M., Mersha A. M., Weldemariam A. H., Wondmeneh T. G., Sreeramareddy C. T., Pinheiro M., Yaseri M., Yu C., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zimsen S. R. M., Yonemoto N., Tsegaye G. W., Vu G. T., Vongpradith A., Renzaho A. M. N., Sorrie M. B., Shaheen A. A., Shiferaw W. S., Skryabin V. Y., Skryabina A. A., Saya G. K., Rahimi-Movaghar V., Shigematsu M., Sahraian M. A., Naderifar H., Sabour S., Rathi P., Sathian B., Miller T. R., Rezapour A., Rawal L., Pham H. Q., Parekh U., Podder V., Onwujekwe O. E., Pasovic M., Otstavnov N., Negash H., Pawar S., Naimzada M. D., Al Montasir A., Ogbo F. A., Owolabi M. O., Pakshir K., Mohammad Y., Moni M. A., Nunez-Samudio V., Mulaw G. F., Naveed M., Maleki S., Michalek I. M., Misra S., Swamy S. N., Mohammed J. A., Flaxman S., Park E. -C., Briant P. S., Meles G. G., Hayat K., Landires I., Kim G. R., Liu X., LeGrand K. E., Taylor H. R., Kunjathur S. M., Khoja T. A. M., Bicer B. K., Khalilov R., Hashi A., Kayode G. A., Carneiro V. L. A., Kavetskyy T., Kosen S., Kulkarni V., Holla R., Kalhor R., Jayaram S., Islam S. M. S., Gilani S. A., Eskandarieh S., Molla M. D., Itumalla R., Farzadfar F., Congdon N. G., Elhabashy H. R., Elayedath R., Couto R. A. S., Dervenis N., Cromwell E. A., Dahlawi S. M. A., Resnikoff S., Casson R. J., Abdoli A., Choi J. -Y. J., Dos Santos F. L. C., Abrha W. A., Nagaraja S. B., Abualhasan A., Adal T. G., Aregawi B. B., Beheshti M., Abu-Gharbieh E., Afshin A., Ahmadieh H., Alemzadeh S. A., Arrigo A., Atnafu D. D., Ashbaugh C., Ashrafi E., Alemayehu W., Alfaar A. S., Alipour V., Anbesu E. W., Androudi S., Arabloo J., Arditi A., Bagli E., Baig A. A., Barnighausen T. W., Battaglia Parodi M., Bhagavathula A. S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bijani A., Bikbov M., Bottone M., Braithwaite T., Bron A. M., Butt Z. A., Cheng C. -Y., Chu D. -T., Cicinelli M. V., Coelho J. M., Dai X., Dana R., Dandona L., Dandona R., Del Monte M. A., Deva J. P., Diaz D., Djalalinia S., Dreer L. E., Ehrlich J. R., Ellwein L. B., Emamian M. H., Fernandes A. G., Fischer F., Friedman D. S., Furtado J. M., Gaidhane S., Gazzard G., Gebremichael B., George R., Ghashghaee A., Golechha M., Hamidi S., Hammond B. R., Hartnett M. E. R., Hartono R. K., Hay S. I., Heidari G., Ho H. C., Househ M., Ibitoye S. E., Ilic I. M., Huang J. J., Ilic M. D., Ingram A. D., Irvani S. S. N., Jha R. P., Kahloun R., Kandel H., Kasa A. S., Kempen J. H., Khairallah M., Khan E. A., Khanna R. C., Khatib M. N., Kim J. E., Kim Y. J., Kisa A., Kisa S., Koyanagi A., Kurmi O. P., Lansingh V. C., Leasher J. L., Leveziel N., Limburg H., Manafi N., Mansouri K., McAlinden C., Mohammadi S. F., Mokdad A. H., Morse A. R., Naderi M., Naidoo K. S., Nangia V., Nguyen H. L. T., Ogundimu K., Olagunju A. T., Panda-Jonas S., Pesudovs K., Peto T., Ur Rahman M. H., Ramulu P. Y., Rawaf D. L., Rawaf S., Reinig N., Robin A. L., Rossetti L., Safi S., Sahebkar A., Samy A. M., Serle J. B., Shaikh M. A., Shen T. T., Shibuya K., Shin J. I., Silva J. C., Silvester A., Singh J. A., Singhal D., Sitorus R. S., Skiadaresi E., Soheili A., Sousa R. A. R. C., Stambolian D., Tadesse E. G., Tahhan N., Tareque Md. I., Topouzis F., Tran B. X., Tsilimbaris M. K., Varma R., Virgili G., Wang N., Wang Y. X., West S. K., Wong T. Y., Jonas J. B., Vos T., Bourne, R. R. A., Steinmetz, J. D., Saylan, M., Mersha, A. M., Weldemariam, A. H., Wondmeneh, T. G., Sreeramareddy, C. T., Pinheiro, M., Yaseri, M., Yu, C., Zastrozhin, M. S., Zastrozhina, A., Zhang, Z. -J., Zimsen, S. R. M., Yonemoto, N., Tsegaye, G. W., Vu, G. T., Vongpradith, A., Renzaho, A. M. N., Sorrie, M. B., Shaheen, A. A., Shiferaw, W. S., Skryabin, V. Y., Skryabina, A. A., Saya, G. K., Rahimi-Movaghar, V., Shigematsu, M., Sahraian, M. A., Naderifar, H., Sabour, S., Rathi, P., Sathian, B., Miller, T. R., Rezapour, A., Rawal, L., Pham, H. Q., Parekh, U., Podder, V., Onwujekwe, O. E., Pasovic, M., Otstavnov, N., Negash, H., Pawar, S., Naimzada, M. D., Al Montasir, A., Ogbo, F. A., Owolabi, M. O., Pakshir, K., Mohammad, Y., Moni, M. A., Nunez-Samudio, V., Mulaw, G. F., Naveed, M., Maleki, S., Michalek, I. M., Misra, S., Swamy, S. N., Mohammed, J. A., Flaxman, S., Park, E. -C., Briant, P. S., Meles, G. G., Hayat, K., Landires, I., Kim, G. R., Liu, X., Legrand, K. E., Taylor, H. R., Kunjathur, S. M., Khoja, T. A. M., Bicer, B. K., Khalilov, R., Hashi, A., Kayode, G. A., Carneiro, V. L. A., Kavetskyy, T., Kosen, S., Kulkarni, V., Holla, R., Kalhor, R., Jayaram, S., Islam, S. M. S., Gilani, S. A., Eskandarieh, S., Molla, M. D., Itumalla, R., Farzadfar, F., Congdon, N. G., Elhabashy, H. R., Elayedath, R., Couto, R. A. S., Dervenis, N., Cromwell, E. A., Dahlawi, S. M. A., Resnikoff, S., Casson, R. J., Abdoli, A., Choi, J. -Y. J., Dos Santos, F. L. C., Abrha, W. A., Nagaraja, S. B., Abualhasan, A., Adal, T. G., Aregawi, B. B., Beheshti, M., Abu-Gharbieh, E., Afshin, A., Ahmadieh, H., Alemzadeh, S. A., Arrigo, A., Atnafu, D. D., Ashbaugh, C., Ashrafi, E., Alemayehu, W., Alfaar, A. S., Alipour, V., Anbesu, E. W., Androudi, S., Arabloo, J., Arditi, A., Bagli, E., Baig, A. A., Barnighausen, T. W., Battaglia Parodi, M., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bijani, A., Bikbov, M., Bottone, M., Braithwaite, T., Bron, A. M., Butt, Z. A., Cheng, C. -Y., Chu, D. -T., Cicinelli, M. V., Coelho, J. M., Dai, X., Dana, R., Dandona, L., Dandona, R., Del Monte, M. A., Deva, J. P., Diaz, D., Djalalinia, S., Dreer, L. E., Ehrlich, J. R., Ellwein, L. B., Emamian, M. H., Fernandes, A. G., Fischer, F., Friedman, D. S., Furtado, J. M., Gaidhane, S., Gazzard, G., Gebremichael, B., George, R., Ghashghaee, A., Golechha, M., Hamidi, S., Hammond, B. R., Hartnett, M. E. R., Hartono, R. K., Hay, S. I., Heidari, G., Ho, H. C., Househ, M., Ibitoye, S. E., Ilic, I. M., Huang, J. J., Ilic, M. D., Ingram, A. D., Irvani, S. S. N., Jha, R. P., Kahloun, R., Kandel, H., Kasa, A. S., Kempen, J. H., Khairallah, M., Khan, E. A., Khanna, R. C., Khatib, M. N., Kim, J. E., Kim, Y. J., Kisa, A., Kisa, S., Koyanagi, A., Kurmi, O. P., Lansingh, V. C., Leasher, J. L., Leveziel, N., Limburg, H., Manafi, N., Mansouri, K., Mcalinden, C., Mohammadi, S. F., Mokdad, A. H., Morse, A. R., Naderi, M., Naidoo, K. S., Nangia, V., Nguyen, H. L. T., Ogundimu, K., Olagunju, A. T., Panda-Jonas, S., Pesudovs, K., Peto, T., Ur Rahman, M. H., Ramulu, P. Y., Rawaf, D. L., Rawaf, S., Reinig, N., Robin, A. L., Rossetti, L., Safi, S., Sahebkar, A., Samy, A. M., Serle, J. B., Shaikh, M. A., Shen, T. T., Shibuya, K., Shin, J. I., Silva, J. C., Silvester, A., Singh, J. A., Singhal, D., Sitorus, R. S., Skiadaresi, E., Soheili, A., Sousa, R. A. R. C., Stambolian, D., Tadesse, E. G., Tahhan, N., Tareque, Md. I., Topouzis, F., Tran, B. X., Tsilimbaris, M. K., Varma, R., Virgili, G., Wang, N., Wang, Y. X., West, S. K., Wong, T. Y., Jonas, J. B., Vos, T., University of Washington [Seattle], Anglia Ruskin University (ARU), Imperial College London, University of Melbourne, Heidelberg University, Jahrom University of Medical Sciences, Aksum University, Cairo University, University of Sharjah, Wolkite University, Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University, The Fred Hollows Foundation, Iran University of Medical Sciences, University of Leipzig Medical Center, University of Thessaly [Volos] (UTH), Visibility Metrics LLC, Adigrat University, San Raffaele Hospital, Tehran University of Medical Sciences (TUMS), Bahir Dar University (BDU), University Hospital of Ioannina, Sultan Zainal Abidin University, Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Charles University [Prague] (CU), Government Medical College Pali, All India Institute of Medical Sciences, National Institute of Biomedical Genomics, Babol University of Medical Sciences, Ufa Eye Research Institute, ondon School of Hygiene & Tropical Medicine, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Employee State Insurance Post Graduate Institute of Medical Sciences and Research, University of Waterloo [Waterloo], Federal Polytechnic School of Lausanne, University of Minho, University of Adelaide, Singapore Eye Research Institute [Singapore] (SERI), Seoul National University Hospital, Hanoi National University of Education (HNUE), IRCCS San Raffaele Scientific Institute [Milan, Italie], University of Porto, Queen's University [Belfast] (QUB), University of Dammam - Imam Abdulrahman Bin Faisal University, Harvard University, University of Michigan [Ann Arbor], University of Michigan System, University of Gondar, Royal Liverpool University Hospital, Universiti Tunku Abdul Rahman (UTAR), National Autonomous University of Mexico (UNAM), Ministry of Health and Medical Education [Iran] (MOHME), Mahatma Gandhi University of Medical Sciences and Technology, Cairo University - Faculty of Medicine, National Institutes of Health [Bethesda] (NIH), Shahroud University of Medical Sciences, Federal University of Sao Paulo (Unifesp), University of Applied Sciences Ravensburg-Weingarten, University of São Paulo (USP), Datta Meghe Institute of Medical Sciences, University College of London [London] (UCL), Haramaya University, Sankara Nethralaya Medical Research Foundation, The University of Lahore, Indian Institute of Public Health Gandhinagar, Hamdan Bin Mohammed Smart University, University of Georgia, University of Utah, Institution of Public Health Sciences, Jigjiga Universit, University of Veterinary and Animal Sciences, Independent Consultant, The Chinese University of Hong Kong [Hong Kong], Manipal academy of Higher Education, Hamad Bin Khalifa University (HBKU), Yale University [New Haven], University of Ibadan, University of Belgrade [Belgrade], Faculty of Science of the University of Kragujevac, University of Kragujevac, Deakin University, Burwood, Australia, Deakin University [Burwood], University of Hail, Mysore Medical College, Banaras Hindu University [Varanasi] (BHU), Ophtalmologistes Associe Monastir, Qazvin University of Medical Sciences, The University of Sydney, John Paul II Catholic University of Lublin (KUL), Institute of Human Virology [Nigeria] (IHVN), Myungsung Medical College, Centre Hospitalier Universitaire Fattouma Bourguiba, Partenaires INRAE, Baku State University, Health Services Academy, L V Prasad Eye Institute, Health Ministers Council Gulf Cooperative Council Stat, Medical College of Wisconsin [Milwaukee] (MCW), Xiamen University Malaysia, Yonsei University, Oslo Metropolitan University (OsloMet), School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia, Brien Holden Vision Institute, Fondation Théa, The Fred Hollows Foundation, Bill & Melinda Gates Foundation, Lions Clubs International Foundation, Sightsavers International, and University of Heidelberg., and GBD 2019 Blindness and Vision Impairment Collaborators* on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study.
Subjects: Pediatrics, medicine.medical_specialty, Refractive error, Visual acuity, genetic structures, Eye disease, 030231 tropical medicine, Population, Glaucoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Global health, 030212 general & internal medicine, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, education, education.field_of_study, business.industry, Articles, General Medicine, Diabetic retinopathy, Macular degeneration, medicine.disease, eye diseases, 3. Good health, medicine.symptom, business
Abstract: Background: Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contribution of avoidable causes of blindness and vision impairment globally from 1990 to 2020. We aimed to compare the results with the World Health Assembly Global Action Plan (WHA GAP) target of a 25% global reduction from 2010 to 2019 in avoidable vision impairment, defined as cataract and undercorrected refractive error. Methods: We did a systematic review and meta-analysis of population-based surveys of eye disease from January, 1980, to October, 2018. We fitted hierarchical models to estimate prevalence (with 95% uncertainty intervals [UIs]) of moderate and severe vision impairment (MSVI; presenting visual acuity from
Published: 2021

29. The promotion of learners’ mental activity while studying Russian morphology

Author: O. A. Skryabina
Subjects: Promotion (rank), media_common.quotation_subject, Morphology (biology), Building and Construction, Mental activity, Psychology, Developmental psychology, media_common
Abstract: The object of the study is the methodology of teaching Russian morphology at secondary school. The subject matter of the research is the teaching potential of morphology for building a system of skills necessary for speech activity and the development of learners’ systematic thinking. The study aims to search for methodological factors that can enhance learners’ mental activity in the process of mastering the morphology of the Russian language. Theoretical research methods (analysis, synthesis, systematisation, generalisation of results) in conjunction with practical research methods (modelling the process of teaching morphology, learning process observation) are employed in the study. The paper examines theoretical sources, practices in teaching morphology at school and suggests ways to reverse negative trends in education. The relevance of the problem is highlighted, in the first place, by the fundamental importance of morphology for learners’ personality development. Secondly, it is emphasised by the fact that modern school-leavers lack the system of morphological skills. Lastly, negative trends in teaching this branch of linguistics as part of the school Russian course persist, which also underlines the relevance of the research. The study focuses on the theoretical aspects of the addressed problem and takes into consideration modern knowledge of psychology, psycholinguistics, linguistics, the methodology of teaching Russian. Additionally, the paper presents methods and techniques of teaching such difficult morphological topics as «The Pronoun», «The Participle», «The Numeral». It is concluded that problem-based learning is effective as its implementation will enable teachers to enhance their students’ mental activity in the process of cognition and optimise the outcomes of teaching Russian morphology at secondary school.
Published: 2021

30. Mycotic eye infections: etiology and treatment features

Author: D.S. Mal’cev, Y.V. Borzova, E.V. Skryabina, T.S. Bogomolova, Y.S. Astahov, and T.S. Varganova
Subjects: medicine.medical_specialty, business.industry, Etiology, Medicine, Eye infection, business, Dermatology
Published: 2021

31. Non-antimicrobial effects of macrolides: literature review

Author: A. Skryabina, V. Nikiforov, M. Shakhmardanov, M. Zastrozhin, and D. Sychev
Subjects: General Medicine
Abstract: The aim of this work is to review current publications on the non-antibacterial effects of macrolides. Macrolides are among the most widely prescribed broad-spectrum antibacterial drugs, especially in patients with respiratory infections. It is now recognized that drugs of this group, in particular azithromycin, also have an immunomodulatory effect, which leads to their therapeutic effect not only in infectious but in other chronic inflammatory diseases also. However, the frequent and prolonged use of macrolides in the treatment of respiratory tract diseases, and recently azithromycin in the treatment of COVID-19, has led to an increase in bacterial resistance to antibiotics of this group. Results: it was shown that one of the key aspects of the development of chronic inflammation of the respiratory tract (for instance, chronic obstructive pulmonary disease) is the loss of the protective epithelial barrier due to the effects of pathogens and pollutants. Azithromycin has been shown to enhance the barrier properties of airway epithelial cells over time, which makes an important contribution to its therapeutic effectiveness. The main non-antibacterial effects of macrolides are considered, which in the future can be applied in treatment of inflammatory diseases associated with airway epithelium damage.
Published: 2021

32. Investigation of Hydrogen Evolution Reaction on (TiCr1.8)xV100 – x Alloys via Impedance Spectroscopy Method

Author: V. I. Kichigin, A. A. Mironova, N. A. Medvedeva, D. Fruchart, and N. E. Skryabina
Subjects: Range (particle radiation), Materials science, Analytical chemistry, Oxide, Intermetallic, Electrochemistry, law.invention, Dielectric spectroscopy, chemistry.chemical_compound, chemistry, law, Physics::Accelerator Physics, Physics::Chemical Physics, Polarization (electrochemistry), Faraday cage, Electrical impedance
Abstract: The behavior of the (TiCr1.8)xV100 – x intermetallic system in the reaction of hydrogen evolution in 1 M KOH solution has been studied by polarization measurements and electrochemical impedance spectroscopy. Cathodic polarization curves and impedance spectra were obtained in the potential range corresponding to the linear region of the log i–E dependence. All investigated alloys have two linear sections on the cathodic polarization curves. The two sections of the potential dependence are also revealed in other electrochemical parameters of the system. Impedance spectroscopy allowed establishing that no thick oxide film is present on the alloys’ surfaces. For the analysis of the obtained impedance spectra, three equivalent electrical circuits were applied, in order to describe the electrochemical hydrogen evolution. The parameters of the Faraday impedance were calculated. Assumptions about the hydrogen evolution reaction behavior according to the Volmer–Heyrovsky mechanism and Temkin adsorption isotherm were made.
Published: 2021

33. Socio-psychological features of religiosity of representatives of scientific intelligentsia

Author: Vadim Minnikov, Inna Kuleshova, and Elena Skryabina
Subjects: Religiosity, Intelligentsia, Sociology, Social psychology
Published: 2021

34. Physical Vapor Deposition Features of Ultrathin Nanocrystals of Bi

Author: Dmitry S, Yakovlev, Dmitry S, Lvov, Olga V, Emelyanova, Pave S, Dzhumaev, Igor V, Shchetinin, Olga V, Skryabina, Sergey V, Egorov, Valery V, Ryazanov, Alexander A, Golubov, Dimitri, Roditchev, and Vasily S, Stolyarov
Abstract: Structural and electronic properties of ultrathin nanocrystals of chalcogenide Bi
Published: 2022

35. The Power of Gene Technologies: 1001 Ways to Create a Cell Model

Author: Maxim Karagyaur, Alexandra Primak, Anastasia Efimenko, Mariya Skryabina, and Vsevolod Tkachuk
Subjects: Gene Editing, Genome, General Medicine, CRISPR-Cas Systems, Cloning, Molecular
Abstract: Modern society faces many biomedical challenges that require urgent solutions. Two of the most important include the elucidation of mechanisms of socially significant diseases and the development of prospective drug treatments for these diseases. Experimental cell models are a convenient tool for addressing many of these problems. The power of cell models is further enhanced when combined with gene technologies, which allows the examination of even more subtle changes within the structure of the genome and permits testing of proteins in a native environment. The list and possibilities of these recently emerging technologies are truly colossal, which requires a rethink of a number of approaches for obtaining experimental cell models. In this review, we analyze the possibilities and limitations of promising gene technologies for obtaining cell models, and also give recommendations on the development and creation of relevant models. In our opinion, this review will be useful for novice cell biologists, as it provides some reference points in the rapidly growing universe of gene and cell technologies.
Published: 2022

36. The EAEU Free Trade Agreements as a New Viable Format for the Russian Trade Policy

Author: V. N. Zuev, E. Ya. Ostrovskaya, and V. Yu. Skryabina
Subjects: Commercial policy, 050208 finance, Index (economics), partners within the free trade agreements, russian and the eaeu trade, business.industry, 05 social sciences, General Medicine, International trade, Revealed comparative advantage, regional trade agreements, trade indices, JZ2-6530, Regional trade, Order (exchange), Political science, 0502 economics and business, International relations, 050207 economics, business, russian trade policy
Abstract: The Regional Trade Agreements (RTA) as a legal format of trade between countries has been actively developed within the last decades. Russian involvement in RTAs until recently was modest. However, after the EAEU creation in 2015, trade policies of the member countries have changed. Setting up the RTAs has become an important priority of the EAEU’s common trade policy. In this study, the assessment is made of the significance for the Russian domestic policies of the already signed and planned FTAs. The focus of the methodology of the study lies in computations of three trade indices: export significance index (suggested by authors and based on the revealed comparative advantage index), trade intensity index and symmetric trade introversion index, which were calculated for the totality of trade partners of Russia for 2019 (193 countries) in order to identify the most promising countries to conclude new FTAs. Authors come to a conclusion that the already signed Russian RTAs and newly planned Russian common FTAs on behalf of the EAEU have a potential to generate trade. Another important result of the study is that it provides the list of the first-priority countries for the new-coming FTAs for Russia and the EAEU partners in terms of efficiency in generating trade, that are - Egypt, Turkey, Algeria, Republic of Korea and Mongolia. The authors suggest to make similar calculations for other countries to support the revealed pattern.
Published: 2021

37. Outdated Vocabulary in the Yakut Language

Author: Alevtina Afanasievna Skryabina
Subjects: Vocabulary, media_common.quotation_subject, Psychology, Linguistics, media_common
Published: 2021

38. Topologies on the n-Element Set Consistent with Topologies Close to Discrete on an (n−1)-Element Set

Author: P. G. Stegantseva and A.V. Skryabina
Subjects: Set (abstract data type), General Mathematics, Element (category theory), Network topology, Topology, Mathematics
Published: 2021

39. Provision of mathematical prerequisites to students in humanities at the Federal University of Yakutia

Author: Laura Agitovna Darbasova, Irina Vasilievna Gogoleva, Alevtina Gavrilovna Skryabina, Galina Ivanovna Alekseeva, and Augustina Vasilievna Ivanova
Subjects: Pedagogical condition, Philology, LC8-6691, Competence, Approaches, Regional studies, Humanitarian direction, Humanitarian specialty, Special aspects of education, Cultural competence, Humanities, Education
Abstract: The purpose of the research is to reveal the problems of studying mathematics by students of the humanities and specialties, using the example of students of the Faculty of Philology and the Institute of Foreign Philology and Regional Studies of the Ammosov North-Eastern Federal University and describe the experience of teaching mathematics, contributing to the formation of general cultural competencies focused on the use of mathematical methods in professional activities. A sociological study was carried out in the form of a written survey of students and conversations with teachers of the Faculty of Philology and the Institute of Foreign Philology and Regional Studies, covering 114 students and 4 teachers. Based on the results of the study, the authors summed up the possibility of spreading this experience, using the proposed educational and methodological complex in other humanitarian areas and specialties.
Published: 2021

40. BRICS and Partnerships for Sustainable Development: Prospects for Trade with Least Developed Countries

Author: Valentina Skryabina and Alexandra Morozkina
Subjects: Physics, Economics and Econometrics, Sociology and Political Science, Humanities, Finance
Abstract: Все больше вопросов освещается странами БРИКС в рамках повестки сотрудничества - неформальное объединение активно вовлечено в решение наиболее острых проблем современности. Именно поэтому выявление возможностей реализации целей устойчивого развития на площадке БРИКС является актуальной темой для исследования. В статье исследуется вопрос достижения наименее развитыми странами (НРС) Цели устойчивого развития (ЦУР) 17.11 в рамках взаимной торговли со странами БРИКС. Цель 17.11 в отличие от других ЦУР должна быть достигнута к 2020 году, однако оценки ВТО показывают, что прогресс идет слишком медленными темпами. На фоне резкого падения международной торговли, которое ожидается в 2020 году ввиду пандемии, вопрос реализации этой цели стоит особенно остро. В статье охарактеризована ситуация выполнения ЦУР 17.11 в текущих условиях, определен характер участия стран БРИКС в достижении целей устойчивого развития и выявлены основные тенденции взаимной торговли между НРС и БРИКС. С использованием расчета двух торговых индексов (склонности к экспорту и интенсивности торговли) выявлены страны, способные нарастить экспорт в БРИКС. К перспективным с точки зрения развития торговли с БРИКС отнесены 13 НРС. Кроме того, страны НРС разделены на кластеры на основании перспективности прямого развития торговли, экономических показателей и структуры экономики. В отдельные кластеры выделены НРС, экономика которых опирается на ОПР и переводы мигрантов, сельское хозяйство, добывающие отрасли, производство, услуги. По итогам кластеризации НРС предположены наиболее действенные для каждой экономики механизмы для увеличения экспортного потенциала. Предложены пути поддержки со стороны БРИКС для основных кластеров НРС. Таким образом, проведенный анализ позволяет странам БРИКС сформировать активную амбициозную повестку в области устойчивого развития, в частности направленную на усиленную поддержку развития торговли в наименее развитых странах для ускоренного вовлечения их в глобальные цепочки добавленной стоимости.
Published: 2021

41. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

Author: Emma Nichols, Jaimie D Steinmetz, Stein Emil Vollset, Kai Fukutaki, Julian Chalek, Foad Abd-Allah, Amir Abdoli, Ahmed Abualhasan, Eman Abu-Gharbieh, Tayyaba Tayyaba Akram, Hanadi Al Hamad, Fares Alahdab, Fahad Mashhour Alanezi, Vahid Alipour, Sami Almustanyir, Hubert Amu, Iman Ansari, Jalal Arabloo, Tahira Ashraf, Thomas Astell-Burt, Getinet Ayano, Jose L Ayuso-Mateos, Atif Amin Baig, Anthony Barnett, Amadou Barrow, Bernhard T Baune, Yannick Béjot, Woldesellassie M Mequanint Bezabhe, Yihienew Mequanint Bezabih, Akshaya Srikanth Bhagavathula, Sonu Bhaskar, Krittika Bhattacharyya, Ali Bijani, Atanu Biswas, Srinivasa Rao Bolla, Archith Boloor, Carol Brayne, Hermann Brenner, Katrin Burkart, Richard A Burns, Luis Alberto Cámera, Chao Cao, Felix Carvalho, Luis F S Castro-de-Araujo, Ferrán Catalá-López, Ester Cerin, Prachi P Chavan, Nicolas Cherbuin, Dinh-Toi Chu, Vera Marisa Costa, Rosa A S Couto, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Vanessa De la Cruz-Góngora, Deepak Dhamnetiya, Diana Dias da Silva, Daniel Diaz, Abdel Douiri, David Edvardsson, Michael Ekholuenetale, Iman El Sayed, Shaimaa I El-Jaafary, Khalil Eskandari, Sharareh Eskandarieh, Saman Esmaeilnejad, Jawad Fares, Andre Faro, Umar Farooque, Valery L Feigin, Xiaoqi Feng, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Irina Filip, Howard Fillit, Florian Fischer, Shilpa Gaidhane, Lucia Galluzzo, Ahmad Ghashghaee, Nermin Ghith, Alessandro Gialluisi, Syed Amir Gilani, Ionela-Roxana Glavan, Elena V Gnedovskaya, Mahaveer Golechha, Rajeev Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Mohammad Rifat Haider, Brian J Hall, Samer Hamidi, Asif Hanif, Graeme J Hankey, Shafiul Haque, Risky Kusuma Hartono, Ahmed I Hasaballah, M Tasdik Hasan, Amr Hassan, Simon I Hay, Khezar Hayat, Mohamed I Hegazy, Golnaz Heidari, Reza Heidari-Soureshjani, Claudiu Herteliu, Mowafa Househ, Rabia Hussain, Bing-Fang Hwang, Licia Iacoviello, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Seyed Sina Naghibi Irvani, Hiroyasu Iso, Masao Iwagami, Roxana Jabbarinejad, Louis Jacob, Vardhmaan Jain, Sathish Kumar Jayapal, Ranil Jayawardena, Ravi Prakash Jha, Jost B Jonas, Nitin Joseph, Rizwan Kalani, Amit Kandel, Himal Kandel, André Karch, Ayele Semachew Kasa, Gizat M Kassie, Pedram Keshavarz, Moien AB Khan, Mahalaqua Nazli Khatib, Tawfik Ahmed Muthafer Khoja, Jagdish Khubchandani, Min Seo Kim, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Mika Kivimäki, Walter J Koroshetz, Ai Koyanagi, G Anil Kumar, Manasi Kumar, Hassan Mehmood Lak, Matilde Leonardi, Bingyu Li, Stephen S Lim, Xuefeng Liu, Yuewei Liu, Giancarlo Logroscino, Stefan Lorkowski, Giancarlo Lucchetti, Ricardo Lutzky Saute, Francesca Giulia Magnani, Ahmad Azam Malik, João Massano, Man Mohan Mehndiratta, Ritesh G Menezes, Atte Meretoja, Bahram Mohajer, Norlinah Mohamed Ibrahim, Yousef Mohammad, Arif Mohammed, Ali H Mokdad, Stefania Mondello, Mohammad Ali Ali Moni, Md Moniruzzaman, Tilahun Belete Mossie, Gabriele Nagel, Muhammad Naveed, Vinod C Nayak, Sandhya Neupane Kandel, Trang Huyen Nguyen, Bogdan Oancea, Nikita Otstavnov, Stanislav S Otstavnov, Mayowa O Owolabi, Songhomitra Panda-Jonas, Fatemeh Pashazadeh Kan, Maja Pasovic, Urvish K Patel, Mona Pathak, Mario F P Peres, Arokiasamy Perianayagam, Carrie B Peterson, Michael R Phillips, Marina Pinheiro, Michael A Piradov, Constance Dimity Pond, Michele H Potashman, Faheem Hyder Pottoo, Sergio I Prada, Amir Radfar, Alberto Raggi, Fakher Rahim, Mosiur Rahman, Pradhum Ram, Priyanga Ranasinghe, David Laith Rawaf, Salman Rawaf, Nima Rezaei, Aziz Rezapour, Stephen R Robinson, Michele Romoli, Gholamreza Roshandel, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Brijesh Sathian, Davide Sattin, Monika Sawhney, Mete Saylan, Silvia Schiavolin, Allen Seylani, Feng Sha, Masood Ali Shaikh, KS Shaji, Mohammed Shannawaz, Jeevan K Shetty, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Diego Augusto Santos Silva, João Pedro Silva, Renata Silva, Jasvinder A Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Amanda E Smith, Sergey Soshnikov, Emma Elizabeth Spurlock, Dan J Stein, Jing Sun, Rafael Tabarés-Seisdedos, Bhaskar Thakur, Binod Timalsina, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Gebiyaw Wudie Tsegaye, Sahel Valadan Tahbaz, Pascual R Valdez, Narayanaswamy Venketasubramanian, Vasily Vlassov, Giang Thu Vu, Linh Gia Vu, Yuan-Pang Wang, Anders Wimo, Andrea Sylvia Winkler, Lalit Yadav, Seyed Hossein Yahyazadeh Jabbari, Kazumasa Yamagishi, Lin Yang, Yuichiro Yano, Naohiro Yonemoto, Chuanhua Yu, Ismaeel Yunusa, Siddhesh Zadey, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, Christopher J L Murray, Theo Vos, Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alipour, V., Almustanyir, S., Amu, H., Ansari, I., Arabloo, J., Ashraf, T., Astell-Burt, T., Ayano, G., Ayuso-Mateos, J. L., Baig, A. A., Barnett, A., Barrow, A., Baune, B. T., Bejot, Y., Bezabhe, W. M. M., Bezabih, Y. M., Bhagavathula, A. S., Bhaskar, S., Bhattacharyya, K., Bijani, A., Biswas, A., Bolla, S. R., Boloor, A., Brayne, C., Brenner, H., Burkart, K., Burns, R. A., Camera, L. A., Cao, C., Carvalho, F., Castro-de-Araujo, L. F. S., Catala-Lopez, F., Cerin, E., Chavan, P. P., Cherbuin, N., Chu, D. -T., Costa, V. M., Couto, R. A. S., Dadras, O., Dai, X., Dandona, L., Dandona, R., De la Cruz-Gongora, V., Dhamnetiya, D., Dias da Silva, D., Diaz, D., Douiri, A., Edvardsson, D., Ekholuenetale, M., El Sayed, I., El-Jaafary, S. I., Eskandari, K., Eskandarieh, S., Esmaeilnejad, S., Fares, J., Faro, A., Farooque, U., Feigin, V. L., Feng, X., Fereshtehnejad, S. -M., Fernandes, E., Ferrara, P., Filip, I., Fillit, H., Fischer, F., Gaidhane, S., Galluzzo, L., Ghashghaee, A., Ghith, N., Gialluisi, A., Gilani, S. A., Glavan, I. -R., Gnedovskaya, E. V., Golechha, M., Gupta, R., Gupta, V. B., Gupta, V. K., Haider, M. R., Hall, B. J., Hamidi, S., Hanif, A., Hankey, G. J., Haque, S., Hartono, R. K., Hasaballah, A. I., Hasan, M. T., Hassan, A., Hay, S. I., Hayat, K., Hegazy, M. I., Heidari, G., Heidari-Soureshjani, R., Herteliu, C., Househ, M., Hussain, R., Hwang, B. -F., Iacoviello, L., Iavicoli, I., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Irvani, S. S. N., Iso, H., Iwagami, M., Jabbarinejad, R., Jacob, L., Jain, V., Jayapal, S. K., Jayawardena, R., Jha, R. P., Jonas, J. B., Joseph, N., Kalani, R., Kandel, A., Kandel, H., Karch, A., Kasa, A. S., Kassie, G. M., Keshavarz, P., Khan, M. A., Khatib, M. N., Khoja, T. A. M., Khubchandani, J., Kim, M. S., Kim, Y. J., Kisa, A., Kisa, S., Kivimaki, M., Koroshetz, W. J., Koyanagi, A., Kumar, G. A., Kumar, M., Lak, H. M., Leonardi, M., Li, B., Lim, S. S., Liu, X., Liu, Y., Logroscino, G., Lorkowski, S., Lucchetti, G., Lutzky Saute, R., Magnani, F. G., Malik, A. A., Massano, J., Mehndiratta, M. M., Menezes, R. G., Meretoja, A., Mohajer, B., Mohamed Ibrahim, N., Mohammad, Y., Mohammed, A., Mokdad, A. H., Mondello, S., Moni, M. A. A., Moniruzzaman, M., Mossie, T. B., Nagel, G., Naveed, M., Nayak, V. C., Neupane Kandel, S., Nguyen, T. H., Oancea, B., Otstavnov, N., Otstavnov, S. S., Owolabi, M. O., Panda-Jonas, S., Pashazadeh Kan, F., Pasovic, M., Patel, U. K., Pathak, M., Peres, M. F. P., Perianayagam, A., Peterson, C. B., Phillips, M. R., Pinheiro, M., Piradov, M. A., Pond, C. D., Potashman, M. H., Pottoo, F. H., Prada, S. I., Radfar, A., Raggi, A., Rahim, F., Rahman, M., Ram, P., Ranasinghe, P., Rawaf, D. L., Rawaf, S., Rezaei, N., Rezapour, A., Robinson, S. R., Romoli, M., Roshandel, G., Sahathevan, R., Sahebkar, A., Sahraian, M. A., Sathian, B., Sattin, D., Sawhney, M., Saylan, M., Schiavolin, S., Seylani, A., Sha, F., Shaikh, M. A., Shaji, K. S., Shannawaz, M., Shetty, J. K., Shigematsu, M., Shin, J. I., Shiri, R., Silva, D. A. S., Silva, J. P., Silva, R., Singh, J. A., Skryabin, V. Y., Skryabina, A. A., Smith, A. E., Soshnikov, S., Spurlock, E. E., Stein, D. J., Sun, J., Tabares-Seisdedos, R., Thakur, B., Timalsina, B., Tovani-Palone, M. R., Tran, B. X., Tsegaye, G. W., Valadan Tahbaz, S., Valdez, P. R., Venketasubramanian, N., Vlassov, V., Vu, G. T., Vu, L. G., Wang, Y. -P., Wimo, A., Winkler, A. S., Yadav, L., Yahyazadeh Jabbari, S. H., Yamagishi, K., Yang, L., Yano, Y., Yonemoto, N., Yu, C., Yunusa, I., Zadey, S., Zastrozhin, M. S., Zastrozhina, A., Zhang, Z. -J., Murray, C. J. L., Vos, T., Department of Public Health, Clinicum, Helsinki University Hospital Area, Bill & Melinda Gates Foundation, University of Porto (Portugal), Medical Research Council (Reino Unido), Fundação para a Ciência e Tecnologia (Portugal), King College London, University College London Hospitals NHS Foundation Trust, NIHR - Oxford Biomedical Research Centre (Reino Unido), Novo Nordisk Foundation, National Health and Medical Research Council (Australia), Jazan University (Arabia Saudí), Romanian National Authority for Scientific Research and Innovation, Xiamen University Malaysia (Malasia), Wellcome Trust, Fogarty International Center (Estados Unidos), Federal Ministry of Education & Research (Alemania), Ministero della Salute (Italia), Coordenação de Aperfeicoamento de Pessoal de Nível Superior (Brasil), Nichols, E, D Steinmetz, J, Emil Vollset, S, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Tayyaba Akram, T, Al Hamad, H, Alahdab, F, Mashhour Alanezi, F, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, L Ayuso-Mateos, J, Amin Baig, A, Barnett, A, Barrow, A, T Baune, B, Béjot, Y, M Mequanint Bezabhe, W, Mequanint Bezabih, Y, Srikanth Bhagavathula, A, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Rao Bolla, S, Boloor, A, Brayne, C, Brenner, H, Burkart, K, A Burns, R, Alberto Cámera, L, Cao, C, Carvalho, F, S Castro-de-Araujo, L, Catalá-López, F, Cerin, E, P Chavan, P, Cherbuin, N, Chu, D, Marisa Costa, V, S Couto, R, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Cruz-Góngora, V, Dhamnetiya, D, Dias da Silva, D, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, I El-Jaafary, S, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, L Feigin, V, Feng, X, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Amir Gilani, S, Glăvan, I, V Gnedovskaya, E, Golechha, M, Gupta, R, Bala Gupta, V, Kumar Gupta, V, Rifat Haider, M, J Hall, B, Hamidi, S, Hanif, A, J Hankey, G, Haque, S, Kusuma Hartono, R, I Hasaballah, A, Tasdik Hasan, M, Hassan, A, I Hay, S, Hayat, K, I Hegazy, M, Heidari, G, Heidari-Soureshjani, R, Herteliu, C, Househ, M, Hussain, R, Hwang, B, Iacoviello, L, Iavicoli, I, Stephen Ilesanmi, O, M Ilic, I, D Ilic, M, Sina Naghibi Irvani, S, Iso, H, Iwagami, M, Jabbarinejad, R, Jacob, L, Jain, V, Kumar Jayapal, S, Jayawardena, R, Prakash Jha, R, B Jonas, J, Joseph, N, Kalani, R, Kandel, A, Kandel, H, Karch, A, Semachew Kasa, A, M Kassie, G, Keshavarz, P, B Khan, M, Nazli Khatib, M, Ahmed Muthafer Khoja, T, Khubchandani, J, Seo Kim, M, Jin Kim, Y, Kisa, A, Kisa, S, Kivimäki, M, J Koroshetz, W, Koyanagi, A, Anil Kumar, G, Kumar, M, Mehmood Lak, H, Leonardi, M, Li, B, S Lim, S, Liu, X, Liu, Y, Logroscino, G, Lorkowski, S, Lucchetti, G, Lutzky Saute, R, Giulia Magnani, F, Azam Malik, A, Massano, J, Mohan Mehndiratta, M, G Menezes, R, Meretoja, A, Mohajer, B, Mohamed Ibrahim, N, Mohammad, Y, Mohammed, A, H Mokdad, A, Mondello, S, Ali Moni, M, Moniruzzaman, M, Belete Mossie, T, Nagel, G, Naveed, M, C Nayak, V, Neupane Kandel, S, Huyen Nguyen, T, Oancea, B, Otstavnov, N, S Otstavnov, S, O Owolabi, M, Panda-Jonas, S, Pashazadeh Kan, F, Pasovic, M, K Patel, U, Pathak, M, P Peres, M, Perianayagam, A, B Peterson, C, R Phillips, M, Pinheiro, M, A Piradov, M, Dimity Pond, C, H Potashman, M, Hyder Pottoo, F, I Prada, S, Radfar, A, Raggi, A, Rahim, F, Rahman, M, Ram, P, Ranasinghe, P, Laith Rawaf, D, Rawaf, S, Rezaei, N, Rezapour, A, R Robinson, S, Romoli, M, Roshandel, G, Sahathevan, R, Sahebkar, A, Ali Sahraian, M, Sathian, B, Sattin, D, Sawhney, M, Saylan, M, Schiavolin, S, Seylani, A, Sha, F, Ali Shaikh, M, S Shaji, K, Shannawaz, M, K Shetty, J, Shigematsu, M, Il Shin, J, Shiri, R, Augusto Santos Silva, D, Pedro Silva, J, Silva, R, A Singh, J, Yurievich Skryabin, V, Aleksandrovna Skryabina, A, E Smith, A, Soshnikov, S, Elizabeth Spurlock, E, J Stein, D, Sun, J, Tabarés-Seisdedos, R, Thakur, B, Timalsina, B, Roberto Tovani-Palone, M, Xuan Tran, B, Wudie Tsegaye, G, Valadan Tahbaz, S, R Valdez, P, Venketasubramanian, N, Vlassov, V, Thu Vu, G, Gia Vu, L, Wang, Y, Wimo, A, Sylvia Winkler, A, Yadav, L, Hossein Yahyazadeh Jabbari, S, Yamagishi, K, Yang, L, Yano, Y, Yonemoto, N, Yu, C, Yunusa, I, Zadey, S, Sergeevich Zastrozhin, M, Zastrozhina, A, Zhang, Z, L Murray, C, and Vos, T
Subjects: Blood Glucose, EUROPE, Sociodemographic Factors, Prevalence forecasts, Population Dynamics, UNITED-STATES, DIAGNOSIS, Global Health, Body Mass Index, Global Burden of Disease, SDG 3 - Good Health and Well-being, Risk Factors, SYSTEMATIC ANALYSIS, Humans, METAANALYSIS, Public, Environmental & Occupational Health, RISK, Population ageing, Public health, Population Dynamic, Sociodemographic Factor, Science & Technology, Risk Factor, Smoking, Public Health, Environmental and Occupational Health, Dementia forecasts, Educational Statu, TRENDS, 3142 Public health care science, environmental and occupational health, ALZHEIMERS-DISEASE, INSIGHTS, Educational Status, Dementia, Public aspects of medicine, RA1-1270, Life Sciences & Biomedicine, MIXED BRAIN PATHOLOGIES, MIDLIFE, Human
Abstract: Background: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of dementia prevalence by producing country-level estimates and incorporating information on selected risk factors. Methods: We forecasted the prevalence of dementia attributable to the three dementia risk factors included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (high body-mass index, high fasting plasma glucose, and smoking) from 2019 to 2050, using relative risks and forecasted risk factor prevalence to predict GBD risk-attributable prevalence in 2050 globally and by world region and country. Using linear regression models with education included as an additional predictor, we then forecasted the prevalence of dementia not attributable to GBD risks. To assess the relative contribution of future trends in GBD risk factors, education, population growth, and population ageing, we did a decomposition analysis. Findings: We estimated that the number of people with dementia would increase from 57·4 (95% uncertainty interval 50·4-65·1) million cases globally in 2019 to 152·8 (130·8-175·9) million cases in 2050. Despite large increases in the projected number of people living with dementia, age-standardised both-sex prevalence remained stable between 2019 and 2050 (global percentage change of 0·1% [-7·5 to 10·8]). We estimated that there were more women with dementia than men with dementia globally in 2019 (female-to-male ratio of 1·69 [1·64-1·73]), and we expect this pattern to continue to 2050 (female-to-male ratio of 1·67 [1·52-1·85]). There was geographical heterogeneity in the projected increases across countries and regions, with the smallest percentage changes in the number of projected dementia cases in high-income Asia Pacific (53% [41-67]) and western Europe (74% [58-90]), and the largest in north Africa and the Middle East (367% [329-403]) and eastern sub-Saharan Africa (357% [323-395]). Projected increases in cases could largely be attributed to population growth and population ageing, although their relative importance varied by world region, with population growth contributing most to the increases in sub-Saharan Africa and population ageing contributing most to the increases in east Asia. Interpretation: Growth in the number of individuals living with dementia underscores the need for public health planning efforts and policy to address the needs of this group. Country-level estimates can be used to inform national planning efforts and decisions. Multifaceted approaches, including scaling up interventions to address modifiable risk factors and investing in research on biological mechanisms, will be key in addressing the expected increases in the number of individuals affected by dementia. F Carvalho and E F Fernandes acknowledge support from the University of Porto (UID/MULTI/04378/2019 and UID/QUI/50006/2019 with funding from FCT/MCTES through national funds). L F S Castro-de-Araujo acknowledges support from the Medical Research Council (London; grant number MC_PC_MR/T03355X/1). V M Costa acknowledges her grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória (DL57/2016/CP1334/CT0006). A Douiri acknowledges support from the NIHR Applied Research Collaboration (ARC) South London at King’s College Hospital NHS Foundation Trust and the Royal College of Physicians, as well as the support from the NIHR Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. N Ghith acknowledges her salary as a postdoc is covered by a grant to her research group provided by Novo Nordisk Foundation. V K Gupta and V B Gupta acknowledge funding support from National Health and Medical Research Council (NHMRC), Australia. S Haque acknowledges support from Jazan University, Saudi Arabia, for providing access to the Saudi Digital Library for this study. C Herteliu is partially supported by a grant of the Romanian National Authority for Scientific Research and Innovation (CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084). Y J Kim was supported by the Research Management Centre, Xiamen University, Malaysia (No. XMUMRF/2020-C6/ITCM/0004). M Kivimäki was supported by the MRC (S011676) and the Wellcome Trust (221854/Z/20/Z). M Kumar acknowledges support from Fogarty International Center (K43 TW010716-04). S Lorkowski acknowledges institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig (Germany; German Federal Ministry of Education and Research, grant agreement number 01EA1808A). S Mondello was supported by the Italian Ministry of Health (GR-2013-02354960). A Raggi acknowledges support from a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C. Besta, Linea – Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). D A S Silva acknowledges support from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES; Finance Code 001 / CAPES-PRINT). J P Silva acknowledges support from the Applied Molecular Biosciences Unit (UCIBIO; grant number UIDB/04378/2020), supported through Portuguese national funds via FCT/MCTES. Sí
Published: 2021

42. Hearing loss prevalence and years lived with disability, 1990-2019: findings from the Global Burden of Disease Study 2019

Author: Rezaul Karim Ripon, Lydia M. Haile, Richard C. Franklin, Virginia Núñez-Samudio, Sonali G. Choudhari, Chythra R Rao, Maria Inês Schmidt, Jeff T. Zhao, Hanadi Al Hamad, Bing-Fang Hwang, Christopher R. Cederroth, Howard J. Hoffman, Naohiro Yonemoto, Rajaa Al-Raddadi, Avina Vongpradith, David Laith Rawaf, Valentin Yurievich Skryabin, Maja Pasovic, Ismail Tareque, Alessandra Lugo, Theo Vos, Rabia Hussain, Golnaz Heidari, Tarik A. Rashid, Ghozali Ghozali, Stephen S Lim, Bay Vo, Emma Elizabeth Spurlock, Himal Kandel, Jitendra Singh, Adrian Davis, Pankaj Bhardwaj, Houman Sotoudeh, Arif Mohammed, Rekha Thapar, Mohammad Rabiee, Florian Fischer, Deepika Singhal, Haroon Ahmed, Irina Filip, Michael Ekholuenetale, Amirhossein Sahebkar, Abdallah M. Samy, Fatemeh Pashazadeh Kan, Sathish Kumar Jayapal, Ionela-Roxana Glavan, Mikhail Sergeevich Zastrozhin, Bruce Bartholow Duncan, Aziz Rezapour, Jalal Arabloo, Sahel Valadan Tahbaz, Chuanhua Yu, Huong Lan Thi Nguyen, Vahid Rashedi, Shrikant Pawar, Shelly Chadha, Mahaveer Golechha, Bach Xuan Tran, Jaimie D Steinmetz, Deepak Dhamnetiya, Olayinka Stephen Ilesanmi, Masood Ali Shaikh, Charlie Ashbaugh, Stany W. Lobo, Akshaya Srikanth Bhagavathula, Biruk Wogayehu Taddele, Baye Dagnew, Walter Mendoza, Morteza Arab-Zozani, Turki Alanzi, Sandhya Neupane Kandel, Kebadnew Mulatu Mihretie, Zaheer-Ud-Din Babar, Jasvinder A. Singh, Veer Bala Gupta, Maheswar Satpathy, Ali H. Mokdad, Simon I. Hay, Sadia Bibi, Louis Jacob, Christopher J L Murray, Liaqat Ali, Keyvan Pakshir, Allen Seylani, Andre M. N. Renzaho, Eman Abu-Gharbieh, Till Bärnighausen, Segun Emmanuel Ibitoye, Voilet Rodrigues, Vahit Yigit, Mohammed Shannawaz, Mohammad Ali Moni, Ali Yadollahpour, Rose G Bender, Victor M. Oguoma, Rohollah Kalhor, Saif Ullah, Mohammad Zamani, Anna Aleksandrovna Skryabina, Mowafa Househ, Milena Santric-Milicevic, Juwel Rana, Fakher Rahim, Soraya Siabani, Mokhtar Mohammadi, Bolajoko O. Olusanya, Khezar Hayat, Teroj Abdulrahman Mohamed, Palash Chandra Banik, Nikha Bhardwaj, Brijesh Sathian, Fahad Alanezi, Jean Jacques Noubiap, Jagadish Rao Padubidri, Hans Orru, Nawzad K. Al-Salihi, Navid Rabiee, Xuefeng Liu, Iván Landires, Paul S Briant, Jost B. Jonas, Mayowa O. Owolabi, Zhi Jiang Zhang, Farhad Ghamari, Vahid Alipour, Sowmya J. Rao, Mehdi Hosseinzadeh, Desta Debalkie Atnafu, Lalit Dandona, Molly R Nixon, Rovshan Khalilov, Ai Koyanagi, Silvano Gallus, Saad M.A. Dahlawi, Salman Rawaf, Mohammad Abdollahi, Ted R. Miller, Masao Iwagami, Amanual Getnet Mersha, Savita Lasrado, Marcos Roberto Tovani-Palone, Umar Saeed, Fares Alahdab, Vafa Rahimi-Movaghar, Ivo Iavicoli, Yonas Akalu, Amir Masoud Rahmani, Kathleen Pillsbury Hopf, Assefa Desalew, Sheikh Mohammed Shariful Islam, Amare Belachew Dagnew, Ravi Prakash Jha, Jacob Olusegun Olusanya, Jingkai Wei, Mandira Lamichhane Dhimal, Kaloyan Kamenov, Anasthasia Zastrozhina, Samer Hamidi, Gbenga A. Kayode, Katrin Burkart, Anjali Singal, Shahina Pardhan, Rakhi Dandona, Jaykaran Charan, Akram Pourshams, Xiaochen Dai, Meghnath Dhimal, Kerrie E. Doyle, Seyed Sina Naghibi Irvani, Shilpa Gaidhane, Francesco Saverio Violante, Monika Sawhney, Animut Tagele Tamiru, Hai Quang Pham, Atif Amin Baig, Hubert Amu, Judie Arulappan, Ayele Semachew Kasa, Alaa Makki, Syed Amir Gilani, Abdollah Mohammadian-Hafshejani, Soewarta Kosen, Abhay Gaidhane, Birhanu Wubale Yirdaw, Ismaeel Yunusa, Ali Bijani, Billy Randall Hammond, Neeti Rustagi, Bogdan Oancea, Ahmad Ghashghaee, Amadou Barrow, Mosiur Rahman, Ashkan Afshin, Yigizie Yeshaw, Mahalaqua Nazli Khatib, Amir Radfar, Winfried Schlee, Andrew T Olagunju, Dinh-Toi Chu, Vasily Vlassov, Ejaz Ahmad Khan, Sanjeev Misra, Rosa A. S. Couto, Marina Pinheiro, Mohammad Hifz Ur Rahman, Amir Abdoli, Bárbara Niegia Garcia de Goulart, Wondimeneh Shibabaw Shiferaw, Seyed Hossein Yahyazadeh Jabbari, Aislyn U. Orji, Vivek Gupta, Giang Thu Vu, G Anil Kumar, Haile L.M., Kamenov K., Briant P.S., Orji A.U., Steinmetz J.D., Abdoli A., Abdollahi M., Abu-Gharbieh E., Afshin A., Ahmed H., Rashid T.A., Akalu Y., Alahdab F., Alanezi F.M., Alanzi T.M., Al Hamad H., Ali L., Alipour V., Al-Raddadi R.M., Amu H., Arabloo J., Arab-Zozani M., Arulappan J., Ashbaugh C., Atnafu D.D., Babar Z.-U.-D., Baig A.A., Banik P.C., Barnighausen T.W., Barrow A., Bender R.G., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bibi S., Bijani A., Burkart K., Cederroth C.R., Charan J., Choudhari S.G., Chu D.-T., Couto R.A.S., Dagnew A.B., Dagnew B., Dahlawi S.M.A., Dai X., Dandona L., Dandona R., Desalew A., Dhamnetiya D., Dhimal M.L., Dhimal M., Doyle K.E., Duncan B.B., Ekholuenetale M., Filip I., Fischer F., Franklin R.C., Gaidhane A.M., Gaidhane S., Gallus S., Ghamari F., Ghashghaee A., Ghozali G., Gilani S.A., Glavan I.-R., Golechha M., Goulart B.N.G., Gupta V.B., Gupta V.K., Hamidi S., Hammond B.R., Hay S.I., Hayat K., Heidari G., Hoffman H.J., Hopf K.P., Hosseinzadeh M., Househ M., Hussain R., Hwang B.-F., Iavicoli I., Ibitoye S.E., Ilesanmi O.S., Irvani S.S.N., Islam S.M.S., Iwagami M., Jacob L., Jayapal S.K., Jha R.P., Jonas J.B., Kalhor R., Al-Salihi N.K., Kandel H., Kasa A.S., Kayode G.A., Khalilov R., Khan E.A., Khatib M.N., Kosen S., Koyanagi A., Kumar G.A., Landires I., Lasrado S., Lim S.S., Liu X., Lobo S.W., Lugo A., Makki A., Mendoza W., Mersha A.G., Mihretie K.M., Miller T.R., Misra S., Mohamed T.A., Mohammadi M., Mohammadian-Hafshejani A., Mohammed A., Mokdad A.H., Moni M.A., Kandel S.N., Nguyen H.L.T., Nixon M.R., Noubiap J.J., Nunez-Samudio V., Oancea B., Oguoma V.M., Olagunju A.T., Olusanya B.O., Olusanya J.O., Orru H., Owolabi M.O., Padubidri J.R., Pakshir K., Pardhan S., Kan F.P., Pasovic M., Pawar S., Pham H.Q., Pinheiro M., Pourshams A., Rabiee N., Rabiee M., Radfar A., Rahim F., Rahimi-Movaghar V., Ur Rahman M.H., Rahman M., Rahmani A.M., Rana J., Rao C.R., Rao S.J., Rashedi V., Rawaf D.L., Rawaf S., Renzaho A.M.N., Rezapour A., Ripon R.K., Rodrigues V., Rustagi N., Saeed U., Sahebkar A., Samy A.M., Santric-Milicevic M.M., Sathian B., Satpathy M., Sawhney M., Schlee W., Schmidt M.I., Seylani A., Shaikh M.A., Shannawaz M., Shiferaw W.S., Siabani S., Singal A., Singh J.A., Singh J.K., Singhal D., Skryabin V.Y., Skryabina A.A., Sotoudeh H., Spurlock E.E., Taddele B.W., Tamiru A.T., Tareque M.I., Thapar R., Tovani-Palone M.R., Tran B.X., Ullah S., Tahbaz S.V., Violante F.S., Vlassov V., Vo B., Vongpradith A., Vu G.T., Wei J., Yadollahpour A., Jabbari S.H.Y., Yeshaw Y., Yigit V., Yirdaw B.W., Yonemoto N., Yu C., Yunusa I., Zamani M., Zastrozhin M.S., Zastrozhina A., Zhang Z.-J., Zhao J.T., Murray C.J.L., Davis A.C., Vos T., Chadha S., Haile, Lydia M, Kamenov, Kaloyan, Briant, Paul Svitil, Orji, Aislyn U, Steinmetz, Jaimie D, Abdoli, Amir, Abdollahi, Mohammad, Abu-Gharbieh, Eman, Afshin, Ashkan, Ahmed, Haroon, Ahmed Rashid, Tarik, Akalu, Yona, Alahdab, Fare, Alanezi, Fahad Mashhour, Alanzi, Turki M, Al Hamad, Hanadi, Ali, Liaqat, Alipour, Vahid, Al-Raddadi, Rajaa M, Amu, Hubert, Arabloo, Jalal, Arab-Zozani, Morteza, Arulappan, Judie, Ashbaugh, Charlie, Atnafu, Desta Debalkie, Babar, Zaheer-Ud-Din, Baig, Atif Amin, Banik, Palash Chandra, Bärnighausen, Till Winfried, Barrow, Amadou, Bender, Rose G, Bhagavathula, Akshaya Srikanth, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bibi, Sadia, Bijani, Ali, Burkart, Katrin, Cederroth, Christopher R, Charan, Jaykaran, Choudhari, Sonali Gajanan, Chu, Dinh-Toi, Couto, Rosa A S, Dagnew, Amare Belachew, Dagnew, Baye, Dahlawi, Saad M A, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Desalew, Assefa, Dhamnetiya, Deepak, Dhimal, Mandira Lamichhane, Dhimal, Meghnath, Doyle, Kerrie E, Duncan, Bruce B, Ekholuenetale, Michael, Filip, Irina, Fischer, Florian, Franklin, Richard Charle, Gaidhane, Abhay Motiramji, Gaidhane, Shilpa, Gallus, Silvano, Ghamari, Farhad, Ghashghaee, Ahmad, Ghozali, Ghozali, Gilani, Syed Amir, Glavan, Ionela-Roxana, Golechha, Mahaveer, Goulart, Bárbara Niegia Garcia, Gupta, Veer Bala, Gupta, Vivek Kumar, Hamidi, Samer, Hammond, Billy Randall, Hay, Simon I, Hayat, Khezar, Heidari, Golnaz, Hoffman, Howard J, Hopf, Kathleen Pillsbury, Hosseinzadeh, Mehdi, Househ, Mowafa, Hussain, Rabia, Hwang, Bing-Fang, Iavicoli, Ivo, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwagami, Masao, Jacob, Loui, Jayapal, Sathish Kumar, Jha, Ravi Prakash, Jonas, Jost B, Kalhor, Rohollah, Kameran Al-Salihi, Nawzad, Kandel, Himal, Kasa, Ayele Semachew, Kayode, Gbenga A, Khalilov, Rovshan, Khan, Ejaz Ahmad, Khatib, Mahalaqua Nazli, Kosen, Soewarta, Koyanagi, Ai, Kumar, G Anil, Landires, Iván, Lasrado, Savita, Lim, Stephen S, Liu, Xuefeng, Lobo, Stany W, Lugo, Alessandra, Makki, Alaa, Mendoza, Walter, Mersha, Amanual Getnet, Mihretie, Kebadnew Mulatu, Miller, Ted R, Misra, Sanjeev, Mohamed, Teroj Abdulrahman, Mohammadi, Mokhtar, Mohammadian-Hafshejani, Abdollah, Mohammed, Arif, Mokdad, Ali H, Moni, Mohammad Ali, Neupane Kandel, Sandhya, Nguyen, Huong Lan Thi, Nixon, Molly R, Noubiap, Jean Jacque, Nuñez-Samudio, Virginia, Oancea, Bogdan, Oguoma, Victor Maduabuchi, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Orru, Han, Owolabi, Mayowa O, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pardhan, Shahina, Pashazadeh Kan, Fatemeh, Pasovic, Maja, Pawar, Shrikant, Pham, Hai Quang, Pinheiro, Marina, Pourshams, Akram, Rabiee, Navid, Rabiee, Mohammad, Radfar, Amir, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahmani, Amir Masoud, Rana, Juwel, Rao, Chythra R, Rao, Sowmya J, Rashedi, Vahid, Rawaf, David Laith, Rawaf, Salman, Renzaho, Andre M N, Rezapour, Aziz, Ripon, Rezaul Karim, Rodrigues, Voilet, Rustagi, Neeti, Saeed, Umar, Sahebkar, Amirhossein, Samy, Abdallah M, Santric-Milicevic, Milena M, Sathian, Brijesh, Satpathy, Maheswar, Sawhney, Monika, Schlee, Winfried, Schmidt, Maria Inê, Seylani, Allen, Shaikh, Masood Ali, Shannawaz, Mohammed, Shiferaw, Wondimeneh Shibabaw, Siabani, Soraya, Singal, Anjali, Singh, Jasvinder A, Singh, Jitendra Kumar, Singhal, Deepika, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sotoudeh, Houman, Spurlock, Emma Elizabeth, Taddele, Biruk Wogayehu, Tamiru, Animut Tagele, Tareque, Md Ismail, Thapar, Rekha, Tovani-Palone, Marcos Roberto, Tran, Bach Xuan, Ullah, Saif, Valadan Tahbaz, Sahel, Violante, Francesco S, Vlassov, Vasily, Vo, Bay, Vongpradith, Avina, Vu, Giang Thu, Wei, Jingkai, Yadollahpour, Ali, Yahyazadeh Jabbari, Seyed Hossein, Yeshaw, Yigizie, Yigit, Vahit, Yirdaw, Birhanu Wubale, Yonemoto, Naohiro, Yu, Chuanhua, Yunusa, Ismaeel, Zamani, Mohammad, Zastrozhin, Mikhail Sergeevich, Zastrozhina, Anasthasia, Zhang, Zhi-Jiang, Zhao, Jeff T, Murray, Christopher J L, Davis, Adrian C, Vos, Theo, and Chadha, Shelly
Subjects: Hearing aid, Male, Hearing loss, medicine.medical_treatment, Psychological intervention, 030204 cardiovascular system & hematology, Affect (psychology), Health Services Accessibility, Global Burden of Disease, 03 medical and health sciences, Tinnitus, Medicine, General & Internal, 0302 clinical medicine, Neonatal Screening, Hearing Aids, Acquired immunodeficiency syndrome (AIDS), Hearing, General & Internal Medicine, Health care, otorhinolaryngologic diseases, Prevalence, Medicine, Humans, Age Factor, Disabled Persons, 030212 general & internal medicine, Hearing Loss, Hearing Lo, 11 Medical and Health Sciences, Science & Technology, business.industry, Infant, Newborn, Age Factors, Infant, GBD 2019 Hearing Loss Collaborators, General Medicine, Articles, medicine.disease, Otitis, Hearing Aid, Cytomegalovirus Infections, Disabled Person, Female, medicine.symptom, business, Life Sciences & Biomedicine, Human, Demography
Abstract: © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability. Methods: We did systematic reviews of population-representative surveys on hearing loss prevalence from 1990 to 2019. We fitted nested meta-regression models for severity-specific prevalence, accounting for hearing aid coverage, cause, and the presence of tinnitus. We also forecasted the prevalence of hearing loss until 2050. Findings: An estimated 1·57 billion (95% uncertainty interval 1·51–1·64) people globally had hearing loss in 2019, accounting for one in five people (20·3% [19·5–21·1]). Of these, 403·3 million (357·3–449·5) people had hearing loss that was moderate or higher in severity after adjusting for hearing aid use, and 430·4 million (381·7–479·6) without adjustment. The largest number of people with moderate-to-complete hearing loss resided in the Western Pacific region (127·1 million people [112·3–142·6]). Of all people with a hearing impairment, 62·1% (60·2–63·9) were older than 50 years. The Healthcare Access and Quality (HAQ) Index explained 65·8% of the variation in national age-standardised rates of years lived with disability, because countries with a low HAQ Index had higher rates of years lived with disability. By 2050, a projected 2·45 billion (2·35–2·56) people will have hearing loss, a 56·1% (47·3–65·2) increase from 2019, despite stable age-standardised prevalence. Interpretation: As populations age, the number of people with hearing loss will increase. Interventions such as childhood screening, hearing aids, effective management of otitis media and meningitis, and cochlear implants have the potential to ameliorate this burden. Because the burden of moderate-to-complete hearing loss is concentrated in countries with low health-care quality and access, stronger health-care provision mechanisms are needed to reduce the burden of unaddressed hearing loss in these settings. Funding: Bill & Melinda Gates Foundation and WHO.
Published: 2020

43. Hydrogen Solid State Storage on MgH2 Compacts for Mass Applications

Author: Daniel Fruchart, Michel Jehan, Nataliya Skryabina, and Patricia de Rango
Subjects: hydrogen storage, magnesium hydride, material process, development of tanks, Metals and Alloys, General Materials Science
Abstract: The mass storage of hydrogen is a challenge considering large industrial applications and continuous distribution, e.g., for domestic use as a future energy carrier that respects the environment. For a long time, molecular hydrogen was stored and distributed, either as a gas (pressurized up to 75 MPa) or as a cryogenic liquid (20.4 K). Furthermore, the atomic storage of hydrogen in the solid-state form via metallic or covalent compounds is still the subject of intense research and limited to a small scale for some practical developments. In addition, other type H chemical storage routes are being tested, such as ammonia and LOHC (Liquid Organic Hydrogen Carrier), etc. In any case, the main constraint remains security. However, Hydrogen Solid State Storage (HSSS) using MgH2 bodies has been shown to be feasible in terms of process and safety. Furthermore, its intrinsic volumetric densification was proven to be much better performing with 106:70:45 kgH2/m3 for solid (RT):LH (20.4 K):gas (75 MPa), respectively. Very early on, fairly reactive MgH2-based pellets were produced (for max. ~27 tons/year) at McPhy Energy using a series of unique and self-built installations. Thus, the design of large instrumented reservoirs was undertaken thanks to fundamental research first carried out at the CNRS. So, prototypes of storage units from 100 to ~5500 kWh have been produced. However, McPhy took other routes a few years ago (smelting and refueling stations) because the HSSS market was not merging at that time. Today, a new operator, Jomi–Leman, therefore, decided to try the challenge again focusing on applications with on-site production and mass HSSS.
Published: 2023

44. Топології на -елементній множині, узгоджені з топологіями близькими до дискретних на -елементній множині

Author: P. G. Stegantseva and A. V. Skryabina
Subjects: Physics, Combinatorics, Sequence, 060106 history of social sciences, Discrete space, 05 social sciences, Open set, 050301 education, 0601 history and archaeology, 06 humanities and the arts, 0503 education, Finite set
Abstract: UDC 519.1 Topologies on a finite set are described by a nondecreasing sequence of nonnegative integers (the vector of topologies). We study $T_0$ -topologies on the $n$-element set that induce topologies with $k > 2^{n - 1} $ on the $(n - 1)$-element set (these induced topologies are called close to the discrete topology). Let $k$ denote the number of open sets in a topology. We obtain the form of the vector of $T_0$ -topologies with $k \geq 5 \cdot 2^{n - 4}$, which are described in works by Stanley and Kolli, and find the values $k \in [5 \cdot 2^{n - 4}, 2^{n - 1}]$, for which $T_0$ -topologies with k open sets do not exist. We describe all labeled $T_0$-topologies and indicate their number for each $k \geq 13 \cdot 2^{n - 5}$ . It is shown that there exist values $k \in (2^{n - 2}, 5 \cdot 2^{n - 4})$ such that any $T_0$ -topology with k open sets can not induce a topology close to the discrete one on an $(n - 1)$-element subset.
Published: 2021

45. SARS-CoV-2 infection in kidney transplant recipients

Author: N. A. Tomilina, V. A. Berdinsky, E. V. Volodina, T. A. Buruleva, E. S. Ivanova, I. V. Ostrovskaya, Vladimir Vinogradov, M. L. Zubkin, D. A. Titov, Irina Kim, M. E. Maltseva, Artyukhina, L. Yu, Frolova, N. F., A. V. Frolov, and I. A. Skryabina
Subjects: Mechanical ventilation, medicine.medical_specialty, ARDS, business.industry, Anemia, medicine.medical_treatment, Hydroxychloroquine, medicine.disease, Procalcitonin, Transplantation, Nephrology, Internal medicine, Medicine, Hypoalbuminemia, Leukocytosis, medicine.symptom, business, medicine.drug
Abstract: The study aimed to assess the clinical course and risk factors for adverse outcomes, as well as the treatment options for COVID-19 in renal transplant recipient (RTR). Patients and methods: a retrospective study included 279 RTRs (M 60.9%, age 49.9±10.9 years), infected with SARS-CoV-2 from 01.04.2020 to 30.11.2020. After confirmation of COVID-19 by PCR and chest CT, MMF/Aza were canceled. In severe cases, the CNI dose was minimized while that of CS was increased. Observation endpoints: hospital discharge/recovery or death. Results: SARS-CoV-2 was identified in 84.2% of RTRs. In almost 90% of patients, the COVID-19 was confirmed by CT data. Duration after transplantation at the time of infection was 54.0 (14.0;108.0) months, in 17.6% of cases it was 6 months or less. 223/79.9% RTRs were treated in the hospital. The period from the onset of the disease to the hospitalization was 6.8±4.5 days. Severe lung damage (>50%) occurred in 43.1% RTRs;45.3% of patients required respiratory support. Hospital mortality was 13.9%, overall mortality was 11.1%. The most common cause of death (93.5%) was acute respiratory distress syndrome (ARDS). The risk factors associated with an unfavorable outcome were a high comorbidity index, the severity of the pulmonary lesion, the degree of graft dysfunction at the onset of the disease, decreased SpO2 and the use of mechanical ventilation, as well as anemia, leukocytosis, lymphocytopenia, and hypoalbuminemia, increased levels of creatinine, AST, CRP, LDH, and D-dimer, interleukin-6 and procalcitonin. Scr during the course of the disease increased from 171.6±78.0 μM to 221.5±121.3 μM (p
Published: 2021

46. Project Activity of the Educational Process for Public Disciplines at a Technical University

Author: I.N. Kuleshova and E.V. Skryabina
Subjects: Engineering management, Engineering, Polymers and Plastics, Process (engineering), business.industry, Technical university, business, General Business, Management and Accounting, Industrial and Manufacturing Engineering
Published: 2021

47. The Art of Domra Playing: To the Question of the Essence of Strokes, Their Classification and Teaching the Stroke Arsenal

Author: Ekaterina G. Skryabina
Subjects: Developmental and Educational Psychology, Music, Education
Published: 2021

48. Epidemiology of COVID-19

Author: Murad Z. Shakhmardanov, Vladimir V. Nikiforov, Anna А. Skryabina, Yuri N. Tomilin, Aida S. Abusueva, and Svetlana V. Burova
Abstract: The review examines and discusses the spread of COVID-19, current sources of the pathogen, mechanisms and ways of transmission of SARS-CoV-2. It is shown that the leading sources of infection in the ongoing COVID-19 pandemic are patients with manifest forms of the disease on the 1st-2nd day of the disease. A week after the appearance of the first symptoms of the disease, the epidemiological significance of patients as sources of infection decreases sharply. And unlike many other respiratory infections, patients with subclinical forms of the disease who remain highly active are less dangerous epidemiologically. Despite the fact that the causative agents of severe acute respiratory syndrome have penetrated into the human population from small vertebrates, the epidemiological significance of the latter in the ongoing COVID-19 pandemic is negligible. The actual mechanism of transmission of SARS-CoV-2 is aspiration. The other mechanisms of pathogen transmission (fecal-oral, transmissible, contact, vertical), previously discussed as competing with aspiration, have no epidemiological significance. The main transmission path of SARS-CoV-2 is airborne. The contact-household transmission path is much less relevant, and other ways are not proven. Leading in the spread of the virus in the human population is a relatively close (up to 2 meters), long-term, not protected by personal protective equipment, contact of the patient with a healthy one. There is no epidemiological significance of long-distance transmission of the virus.
Published: 2021

49. THE USE OF SCHISANDRA CHINENSIS IN FEEDING YOUNG FOXES IN YAKUTIA

Author: A. G. Cherkashina, T. N. Skryabina, and N.N. Novikova
Subjects: biology, Traditional medicine, Schisandra chinensis, biology.organism_classification
Published: 2021

50. The concept of «intelligentsia» though the eyes of modern Russian youth: a sociological study

Author: Elena Skryabina and Inna Kuleshova
Subjects: Intelligentsia, Gender studies, Sociology
Abstract: The article analyzes a unique empirical material obtained in the course of a sociological study, the purpose of which is to reveal the content of the concept «intelligentsia» as it is comprehended by modern Russian youth. The author studies the correlation of this content with the traditional under-standing of the intelligentsia, presented in the leading Russian sociological approaches: socio-economic, cultural, social-ethical, and others. The main method of collecting primary sociological information is a questionnaire survey, which allows respondents to rank psychological, cognitive, socio-role, moral and ethical markers of the intelligentsia, as well as the markers that characterize the overall level of culture and education of a person. It is revealed that as the main ones, respondents use blocks that cover cognitive characteristics and markers of the general level of culture and upbringing. Moral, ethical and psychological properties and qualities are taken into account to a much lesser extent, while traditional social markers (belonging to a certain social stratum/group/class, profession/occupation/type of occupation, social attitudes and motivation, etc.) remain the outsiders of the sample. Based on the obtained data, a collective image of the intelligentsia through the eyes of modern Russian youth is formed. An opinion about the relevance of the resulting image to almost any person who has received a decent upbringing and education (regardless of the country of residence of this person, their civil position, moral and psychological qualities and characteristics, etc.) is discussed. It is concluded that modern Russian youth, who are not familiar with the etymology and classical interpretations of the concept of «intelligentsia», «dissolves» it in a close, but not identical concept of «intelligence».
Published: 2020

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