44 results on '"Shu-Juan Yang"'
Search Results
2. Combinational quorum sensing devices for dynamic control in cross-feeding cocultivation
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Chunjiang Liu, Xue Liu, Yanting Xue, Guangrong Zhao, Shu-juan Yang, Shengbo Wu, Chengyang Xu, Aidong Yang, Jiaheng Liu, Jianjun Qiao, and Hongji Zhu
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Computer science ,Microbial Consortia ,Quorum Sensing ,Bioengineering ,Dynamic control ,Toggle switch ,Applied Microbiology and Biotechnology ,Coculture Techniques ,Quorum sensing ,Synthetic biology ,Cell density ,Carbon source ,Biochemical engineering ,Biotechnology - Abstract
Quorum sensing (QS) offers cell density dependent dynamic regulations in cell culture through devices such as synchronized lysis circuit (SLC) and metabolic toggle switch (MTS). However, there is still a lack of studies on cocultivation with a combination of different QS-based devices. Taking the production of isopropanol and salidroside as case studies, we have mathematically modeled a comprehensive set of QS-regulated cocultivation schemes and constructed experimental combinations of QS devices, respectively, to evaluate their feasibility and optimality for regulating growth competition and corporative production. Glucose split ratio is proposed for the analysis of competition between cell growth and targeted production. Results show that the combination of different QS devices across multiple members offers a new tool with the potential to effectively coordinate synthetic microbial consortia for achieving high product titer in cross-feeding cocultivation. It is also evident that the performance of such systems is significantly affected by dynamic characteristics of chosen QS devices, carbon source control and the operational settings. This study offers insights for future applications of combinational QS devices in synthetic microbial consortia.
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- 2021
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3. Apical aneurysm formation in apical hypertrophic cardiomyopathy: Pilot study with cardiac magnetic resonance
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Kai Yang, Shi-Qin Yu, Xiu-Yu Chen, Yan-Yan Song, Shu-Juan Yang, Chen Cui, Kan-Kan Zhao, Meng-Die Wei, Min-Jie Lu, and Shi-Hua Zhao
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Cardiology and Cardiovascular Medicine - Abstract
The dynamic changes and apical aneurysm formation in apical hypertrophic cardiomyopathy (HCM) have not been specifically described. This study aimed to describe these changes to better understand the progression of apical HCM.Seventy-two patients with apical HCM who underwent at least two cardiac magnetic resonance (CMR) examinations were retrospectively included in this study. The mean interval between the first and last CMR examinations was 50.1 ± 26.8 months (ranging from 4 to 118 months). Compared with the initial values, the left atrial diameter, maximum left ventricular wall thickness and late gadolinium enhancement extent significantly increased (all P 0.05), while the left ventricular ejection fraction significantly decreased (P 0.05), at the latest CMR examination. More importantly, the dynamic process of apical aneurysm formation in apical HCM was observed in a subset of patients, which may follow these four stages: starting with systolic apical cavity obliteration, then broadening of the apical slit in systole, further developing into an apical outpouching, and finally forming an apical aneurysm. Eleven patients experienced adverse cardiovascular events, including new-onset or progressive atrial fibrillation (n = 7), hospitalization with heart failure (n = 3) and implantable cardioverter defibrillator intervention (n = 1), at the time of the latest CMR examination.In the progression of apical HCM, cardiac structure and function will change accordingly. Apical aneurysm formation in apical HCM is a chronic and continuous dynamic process that may follow a 4-step pathway of disease progression.
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- 2022
4. Calcium snapshots in the stigma and style of medlar (Lycium barbarum L.) during pollen germination and pollen tube growth suggest active calcium oscilations
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Shu Juan Yang, Wen Yu Liang, Jing Shi, Li Peng, and Rui Zheng
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0106 biological sciences ,Exudate ,010506 paleontology ,Gynoecium ,biology ,food and beverages ,chemistry.chemical_element ,Plant Science ,Calcium ,biology.organism_classification ,medicine.disease_cause ,010603 evolutionary biology ,01 natural sciences ,Anthesis ,chemistry ,Germination ,Pollen ,Botany ,medicine ,Pollen tube ,Lycium ,medicine.symptom ,Ecology, Evolution, Behavior and Systematics ,0105 earth and related environmental sciences - Abstract
The stigma (tip of the pistil) of medlar is wet and covered with stigmatic exudate at anthesis. The exudate contains many vesicles with abundant calcium precipitates. After deposition on th...
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- 2019
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5. [The Study of the Relationship Between Community Social Capital and Quality of Life among the Middle-aged and Elderly Rural-to-Urban Residents]
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Qiao-Yu, He, Hui, Hu, Bo, Gao, Shu-Juan, Yang, and Ning-Xiu, Li
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Rural Population ,Urban Population ,Health Status ,Quality of Life ,Humans ,Social Capital ,Middle Aged ,Aged - Abstract
To analyze the relationship between community social capital and quality of life among the middle-aged and elderly rural-to-urban residents, and to provide the policy reference for improving the health status.A multi-stage random sampling method was used to select the research objects. Univariate analysis and logistic regression model were used to explore the effect of social capital on quality of life among the middle-aged and elderly rural-to-urban urbanized residents.The scores of self-rated physical health and mental health in the rural-to-urban residents were lower than those of urban residents (There is a correlation between community belonging, community cohesion and quality of life among the elderly rural-to-urban residents. Attention should be paid to the promotion of community social capital so as to improve the health status of middle-aged and elderly rural-to-urban residents.
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- 2020
6. Isolation of the sperm and egg cells in wild rice (Oryza officinalis) as a mechanism for crop improvement
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Shu Juan Yang, Chengke Luo, Cheng Cheng, and Wei Deng
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0106 biological sciences ,Egg cell ,Plant Science ,Flowers ,Biology ,medicine.disease_cause ,01 natural sciences ,Crop ,Pollen ,Botany ,medicine ,Cultivar ,Pectinase ,Ovule ,food and beverages ,Agriculture ,Oryza ,Cell Biology ,Sperm ,Crop Production ,medicine.anatomical_structure ,Officinalis ,Germ Cells, Plant ,010606 plant biology & botany - Abstract
Sperm cells can be isolated from the mature pollen grains of medicinal wild rice (Oryza officinalis) using an osmotic shock method, and the viable egg cells can be isolated by enzymatic digestion and mechanical dissection steps. Favorable alleles for rice breeding have been identified in natural cultivars and wild rice by association analysis of known functional genes with target trait performance. Transferring these genes from wild rice into cultivated rice varieties is one of the important objectives for rice breeders. The isolation of the sperm and egg cells of wild and cultivated rice is a prerequisite for the in vitro hybridization of distantly related cultivated rice and wild rice lines. Here, we provide a technical approach for isolating the sperm and egg cells of wild rice (Oryza officinalis). In this method, sperm cells were isolated from the mature pollen grains of medicinal wild rice (O. officinalis) according to an osmotic shock method. Additionally, viable O. officinalis egg cells were isolated following enzymatic digestion and mechanical dissection steps. Specifically, ovules were digested in an enzymatic solution containing pectinase and cellulase for 30 min, after which the ovule was cut into two halves. Three egg apparatus cells were released by gently applying pressure to the micropylar end. Generally, six or seven egg cells could be isolated from 20 ovules in 60 min. The same method was used to isolate zygotes from flowers at 24 h after pollination. This technology solved the difficulty of isolating sperm and egg cells in O. officinalis and allowed the isolated sperm and egg cells to be combined by in vitro hybridization of distantly related wild and cultivated rice lines.
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- 2019
7. Correction to: Isolation of the sperm and egg cells in wild rice (Oryza officinalis) as a mechanism for crop improvement
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Wei Deng, Cheng Cheng, Shu Juan Yang, and Chengke Luo
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Crop ,Horticulture ,Oryza officinalis ,Cell Biology ,Plant Science ,Biology ,Isolation (microbiology) ,Sperm - Abstract
The funding section of the original publication gave a wrong funding number.
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- 2020
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8. Prevalence and Years of Life Lost due to Disability from Dental Caries among Children and Adolescents in Western China, 1990-2015
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Zhuo, Wang, Ying, Deng, Shi Wei, Liu, Jun, He, Kui, Ji, Xin Ying, Zeng, Shu Juan, Yang, Xin Yin, Xu, Yu, Luo, Mai Geng, Zhou, and Jian Xin, Zhang
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Male ,China ,Adolescent ,Child, Preschool ,Prevalence ,Humans ,Disabled Persons ,Female ,Dental Caries ,Child - Abstract
To analyze the prevalence and years lived with disability (YLD) from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China.Based on the Global Burden of Disease Study 2015 (GBD2015), which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China. We then used the Bayesian meta-regression method to estimate the sex- and age-specific prevalences and YLDs from dental caries among children and adolescents under 15 years old in Sichuan province and compared them with global and national indicators for the same period.In 2015, there were almost 6 million cases of dental caries in children and adolescents (aged15 years) in Sichuan province, accounting for 6% of the total cases in China. For children under 5 years, the prevalence of deciduous caries was 55.9%, and the YLDs value was 10.8 per 100,000, while it was 24.3% and 5.1 per 100,000 respectively among 5- to 14-year-olds; for those aged 5 to 14 years, the prevalence of permanent caries was 21.5%, and the YLDs value was 11.5 per 100,000. From 1990 to 2015, the prevalence of dental caries for children under 5 years increased substantially, by 16.2%, and the YLDs increased by 8.7%. Among those aged 5 to 14 years, the prevalence increased and the YLDs decreased.Dental caries remains a huge health burden in Western China. In contrast to the global and national data, the trend has increased rapidly over the past 25 years in this region. This work provides suggestions for the prevention and control for oral health in China with the policy of two-child.
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- 2017
9. Isolation of sperm cells, egg cells, synergids and central cells from Solanum verbascifolium L
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Dong Mei Wei, Hui Qiao Tian, and Shu Juan Yang
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Egg cell ,In vitro fertilisation ,biology ,medicine.medical_treatment ,Plant Science ,biology.organism_classification ,Sperm ,In vitro ,Cell biology ,medicine.anatomical_structure ,Human fertilization ,Botany ,medicine ,Pollen tube ,Solanum ,Ovule ,Agronomy and Crop Science ,Biotechnology - Abstract
Sperm cells of Solanum verbascifolium L. were isolated by using an in vivo/in vitro method. Hand-pollinated styles were first grown in vivo for several hours, then cut off from their base and cultured in vitro until pollen tubes grew out from the cut end. When the pollen tubes were transferred to broken solution, the sperm cells were released from broken tubes. For isolation of egg cells and associated cells, ovules were digested in an enzymatic solution for 10–20 min and then transferred to an isolation solution without enzymes for the dissection. The digested ovules were cut transversely and the micropyle end was compressed to release the egg apparatus and central cell. Typically, 7–10 egg cells could be isolated in 1 h and batches of cells could be collected together and concentrated using a micromanipulator. The protocol reported here for the isolation of sperm cells and egg cells of S. verbascifolium potentially provides a basis for in vitro fertilization of this dicotyledonous plant, and for the provision of materials for molecular-biological investigations of the mechanisms of fertilization.
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- 2014
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10. Cytochemical study of developing anthers of Amomum villosum Lour
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Dong Mei Wei, Shu Juan Yang, Hui Qiao Tian, Yun Zhu, and Mei Zhen Lin
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Ecology ,biology ,Starch ,Callose ,Stamen ,food and beverages ,Amomum villosum ,Plant Science ,medicine.disease_cause ,biology.organism_classification ,Staining ,chemistry.chemical_compound ,Sporopollenin ,chemistry ,Microspore ,Pollen ,Botany ,medicine ,Ecology, Evolution, Behavior and Systematics - Abstract
We analyzed anther development in Amomum villosum Lour. (Zingiberaceae) using the periodic acid-Schiff's technique and Sudan black staining to test for the presence of starch and lipids, respectively. Our analyses showed that microspore mother cells of A. villosum lack typical callose walls, and numerous lipid granules appear in the cells early in development. Some starch granules are present in anther wall cells, but not in tapetal cells. After meiosis, numerous lipid granules remain unchanged in the microspores. During microspore development, some small starch granules first appear in the central cell region, and then the starch granules increase in size. After microspore division, the bicellular pollen grains become filled with starch and lipids, and remain in this state until the pollen grains reach maturity. At anthesis, the anther wall of A. villosum consists of several layers of endothecium cells with an evidently thickened radial wall, and some layers of parenchyma cells containing numerous starch granules.
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- 2014
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11. A Convenient and Simple Synthesis of Densely Functionalized Cyclopenta[cd]azulenes and Cyclopenta[ef]heptalenes
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Jun-Xiong Chen, Chi-Phi Wu, Badugu Devendar, Ling-Yu Cheng, Chien-Kuo Ku, and Shu-Juan Yang
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Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Simple (abstract algebra) ,Computational chemistry ,Organic Chemistry ,Drug Discovery ,Physical and Theoretical Chemistry ,Azulene ,Biochemistry ,Tropolone ,Catalysis - Abstract
Syntheses of novel cyclopenta[cd]azulenes, 5, 8, and 13, 1,2-dihydrocyclopenta[cd]azulenes, 6 and 12, and cyclopenta[ef]heptalenes, 10, 15, and 16, by simple procedures starting from tropolone in 6–8 steps are described.
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- 2014
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12. Deep genetic divergence within a 'living fossil' brachiopod Lingula anatina
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Xulong Lai, Shuoshuo Wang, Shu-juan Yang, and Guilian Sheng
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0106 biological sciences ,0301 basic medicine ,Paleontology ,Marine invertebrates ,Biology ,Anatina ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Lingula ,Genetic divergence ,03 medical and health sciences ,Lingula anatina ,Phylogeography ,030104 developmental biology ,Quaternary ,Living fossil - Abstract
The geographic population patterns of Lingula anatina across the Indo-West Pacific region are analyzed based on mitochondrial COI and nuclear EF-1α gene sequences. Compared with the remarkable morphological stasis, genetic evidence of extant Lingula species displays deep genetic divergence. Three distinct COI lineages were detected for L. anatina, one of which is from Qinhuangdao (Hebei, China, Bohai Sea), the other two from Beihai (Guangxi, China, Gulf of Tonkin). Individuals from South Japan have a very close relationship with one of the two COI lineages found in Beihai, which is also supported by EF-1α results, suggesting a relatively recent migration between South China Sea and East China Sea. Genetic distances between the three lineages of L. anatina are rather high (8.9%, 8.6%, and 2.7%), and those between L. anatina and L. adamsi is much higher (44.5%), compared to other marine invertebrates. Both tectonic evolution and the repeated Quaternary glaciations have contributed to the complex phylogeographic pattern found in these recent Lingula anatina populations.
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- 2013
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13. Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses
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Hui Lan, Chun-Xia Yang, Marie Loh, Zhi Tian, He Huang, Feng Chen, Xiong-Fei Pan, Richie Soong, Shu-Juan Yang, Yuan-Yuan Wen, and Yao Xie
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Male ,Oncology ,China ,Cancer Research ,medicine.medical_specialty ,Genotype ,Epidemiology ,Single-nucleotide polymorphism ,Biology ,Bioinformatics ,Polymorphism, Single Nucleotide ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,parasitic diseases ,medicine ,Humans ,Family history ,Promoter Regions, Genetic ,Survival rate ,Neoplasm Staging ,Haplotype ,Public Health, Environmental and Occupational Health ,Case-control study ,Interleukin ,Middle Aged ,Prognosis ,Interleukin-10 ,Survival Rate ,Interleukin 10 ,Haplotypes ,Case-Control Studies ,Female ,Follow-Up Studies - Abstract
Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China.We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 AC and IL10-1082 AG polymorphisms were determined by Sequenom MassARRAY analysis.Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P0.01) and alcohol drinking (54.6% versus 43.2%, P0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients and controls (P0.01 and P=0.03). Variant genotypes of IL10-592 AC and IL10-1082 AG were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC.In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.
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- 2013
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14. Prediction Role of Seven SNPs of DNA Repair Genes for Survival of Gastric Cancer Patients Receiving Chemotherapy
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Hong-Zhi Zou and Shu-Juan Yang
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Cancer Research ,medicine.medical_specialty ,Pathology ,DNA Repair ,Genotype ,Epidemiology ,DNA repair ,medicine.medical_treatment ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Gastroenterology ,XRCC1 ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Genotyping ,Chemotherapy ,Public Health, Environmental and Occupational Health ,Cancer ,Prognosis ,medicine.disease ,Real-time polymerase chain reaction ,Oncology - Abstract
We aimed to investigate DNA repair gene expression of response to chemotherapy among gastric patients, and roles in the prognosis of gastric cancer. A total of 209 gastric cancer patients were included in this study between January 2007 and December 2008, all treated with chemotherapy. Polymorphisms were detected by real time PCR with TaqMan probes, and genomic DNA was extracted from peripheral blood samples. The overall response rate was 61.2%. The median progression and overall survivals were 8.5 and 18.7 months, respectively. A significant increased treatment response was found among patients with XPG C/T+T/T or XRCC1 399G/ A+A/A genotypes, with the OR (95% CI) of 2.14 (1.15-4.01) and 1.75 (1.04-3.35) respectively. We found XPG C/T+T/T and XRCC1 399 G/A+A/A were associated with a longer survival among gastric cancer patients when compared with their wide type genotypes, with HRs and 95% CIs of 0.49 (0.27-0.89) and 0.56 (0.29-0.98) respectively. Selecting specific chemotherapy based on pretreatment genotyping may be an innovative strategy for further studies.
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- 2012
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15. Preliminary Research of Manufacturing Technology for ITER Magnet Supports
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Shu Juan Yang, Peng Yuan Li, Bing Lin Hou, and Chuan Jie Pan
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Engineering ,Manufacturing technology ,business.industry ,Electromagnetic coil ,Magnet ,Nuclear engineering ,Toroidal field ,Poloidal field ,General Medicine ,Structural engineering ,business - Abstract
The International Thermal Experiment Reactor (ITER) is designed to operate for 20 years with high safety requirements. The magnets with their total weight being about 10,000t sit at the core of the ITER machine. In order to guarantee the safety of the ITER machine, the research of the manufacturing technology for ITER magnet supports (MS) is an indispensable working procedure before the MS are produced. The MS consist of toroidal field (TF) gravity supports (GS), poloidal field (PF) supports and correction coils (CC) supports. This paper summarizes that the preliminary research results for the manufacturing of the GS with thermal anchor, the reliable method to manufacture the U-shaped clamp with tapered slots for PF coil supports and the special devices for test of full-size fasteners used in all the MS.
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- 2012
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16. Welding Technology of Gold Alloy
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Na Yin, Wen Qing Qu, Shu Juan Yang, Rui Li, and Ying Ding
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Materials science ,Metallurgy ,General Engineering ,Intermetallic ,Brush ,chemistry.chemical_element ,Welding ,Solderability ,Copper ,law.invention ,Slip ring ,chemistry ,law ,Soldering ,Eutectic system - Abstract
Conducting ring is an electric transmission device to achieve current, video, data signal and power transmission between two relatively slewing mechanism, so it has been widely used in all kinds of precision turntable and inertial navigation equipment. The slip ring and brush wire of conducting ring are connected to other equipment by copper wire or copper transfer metal plates. Currently, Eutectic 63Sn-37Pb solder and electric iron manual welding are often used. But for gold alloy, when SnPb solder is used, gold element will dissolve in solder because Au dissolves in Sn easily, and brittleness intermetallic was produced at the interface during cooling, which embrittled the joint. This paper analyzed the solderability of gold alloy and copper, summed up the research status of soldering technology of gold alloy and copper in China and abroad. It pointed out that it is necessary and urgent to develop soldering technology of gold alloy with copper.
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- 2012
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17. Polymorphisms of XRCC1 and ADPRT Genes and Risk of Noncardia Gastric Cancer in a Chinese Population: a Case-control Study
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Shu-Juan Yang, Feng Chen, Hui Lan, He Huang, Marie Loh, Yuan-Yuan Wen, Xiong-Fei Pan, Chun-Xia Yang, Zhi Tian, Yao Xie, and Richie Soong
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Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Genotype ,Epidemiology ,Poly (ADP-Ribose) Polymerase-1 ,Adenocarcinoma ,XRCC1 ,Asian People ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,medicine ,Genetic predisposition ,Humans ,Family history ,Genotyping ,Gene ,Neoplasm Staging ,Genetics ,Polymorphism, Genetic ,business.industry ,Public Health, Environmental and Occupational Health ,Case-control study ,Middle Aged ,Prognosis ,DNA-Binding Proteins ,X-ray Repair Cross Complementing Protein 1 ,Case-Control Studies ,Female ,Poly(ADP-ribose) Polymerases ,business ,Follow-Up Studies - Abstract
Objective: Gastric cancer (GC) is one of the most common malignancies and its mortality ranks third among all cancers in China. We previously noted that XRCC1 Arg194Trp was associated with GC risk in Western China in a study on XRCC1 Arg194Trp and ADPRT Val762Ala. We aimed to further explore the association of these polymorphisms with risk of the noncardia subtype. Methods: We enrolled 176 noncardia GC patients and 308 controls from four hospitals and a community between October 2010 and August 2011. Genotyping was performed in a 384-well plate format on the Sequenom MassARRAY platform. A self-designed questionnaire was utilized to collect epidemiological data from the subjects regarding demographic factors and potential risk factors. Results: Subjects were aged 56.8±11.8 (mean ± standard deviation) and 57.6±11.1 years in the case and control groups, respectively. Individuals carrying the XRCC1 Trp/Trp or Arg/Trp variant genotype were at significantly increased risk of noncardia GC (adjusted OR, 1.48; 95% CI, 1.00-2.17), after adjustment for family history of cancer, drinking, and smoking. The increased risk of XRCC1 Arg194Trp variant genotype was more pronounced among subjects below 60 years old (adjusted OR, 1.78; 95% CI, 1.07-2.96), compared to older individuals. ADPRT Val762Ala variants (Ala/Ala or Val/Ala) were not associated with noncardia GC (adjusted OR, 1.03; 95% CI, 0.69-1.54). Conclusions: Our study suggests that XRCC1 Arg194Trp is a genetic susceptibility factor for developing noncardia GC in Han Chinese in Western China. In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.
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- 2012
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18. DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis
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Shu-Juan Yang, Dong-Xiao Yao, Da-Qing Chen, and Hong-Yang Zhao
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Adult ,Male ,Oncology ,China ,Cancer Research ,medicine.medical_specialty ,DNA Repair ,Genotype ,Epidemiology ,DNA repair ,Biology ,Polymorphism, Single Nucleotide ,Risk Factors ,Internal medicine ,Glioma ,medicine ,TaqMan ,Humans ,Genetic Predisposition to Disease ,Genotyping ,Xeroderma Pigmentosum Group D Protein ,Brain Neoplasms ,Significant difference ,Public Health, Environmental and Occupational Health ,Middle Aged ,Endonucleases ,Prognosis ,medicine.disease ,DNA-Binding Proteins ,Increased risk ,Case-Control Studies ,Cancer research ,Female ,ERCC1 - Abstract
Aims: We conducted a case-control study in a Chinese population to clarify the association between polymorphisms in ERCC1 and XPD and susceptibility and survival of glioma. Methods: A total of 393 cases and 410 controls were selected from March 2007 to December 2011. Genotyping of ERCC1 and XPD was conducted by TaqMan assays using the ABI Prism 7911HT Sequence Detection System. All analyses were performed using the STATA statistical package. Results: Polymorphisms in ERCC1 118C/T, ERCC1 8092C/A and XPD Asp312Asn showed no statistically significant difference between glioma cases and controls. However, individuals with the XPD 751Gln/Gln genotype had an increased risk of developing glioma compared with those with the Lys/Lys genotype (adjusted OR=1.64, 95% CI: 1.06-2.89). The ERCC1 118T/T genotype was associated with significantly higher median survival than the ERCC1 C/C genotype (HR=0.67, 95%CI=0.35-0.96). In addition, individuals with XPD 751Gln/Gln had a lower median survival time than XPD Lys/Lys carriers (HR=0.54, 95%CI=0.370.93). Conclusion: In conclusion, we observed that the XPD 751Gln/Gln genotype is associated with glioma susceptibility, and ERCC1 118 T/T and XPD 751Gln/Gln genotypes confer a significantly better prognosis.
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- 2012
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19. ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China
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Zhi Tian, Wen-Zhi Huang, Shu-Juan Yang, He Huang, Yao Xie, Si-Han Lv, Xiong-Fei Pan, Yuan-Yuan Wen, Marie Loh, Richie Soong, and Chun-Xia Yang
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Oncology ,China ,Cancer Research ,medicine.medical_specialty ,Genotype ,Epidemiology ,Poly (ADP-Ribose) Polymerase-1 ,Demographic data ,Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,XRCC1 ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Family history ,Neoplasm Staging ,Genetics ,business.industry ,Public Health, Environmental and Occupational Health ,Cancer ,DNA ,Prognosis ,medicine.disease ,DNA-Binding Proteins ,X-ray Repair Cross Complementing Protein 1 ,Lifestyle factors ,Increased risk ,Case-Control Studies ,Gene-Environment Interaction ,Poly(ADP-ribose) Polymerases ,business - Abstract
Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched casecontrol study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P
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- 2012
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20. Intensive Development and Comprehensive Utilization of Metallurgical Slag
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Shu Juan Yang, Li Wei Zhang, and De Hu Yu
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Engineering ,Municipal solid waste ,Waste management ,Ferrous metallurgy ,business.industry ,visual_art ,Metallurgy ,Metallurgical slag ,visual_art.visual_art_medium ,Slag ,General Medicine ,business ,Metallurgical industry - Abstract
With the rapid development of metallurgical industry, there are more and more accumulative and newly-generated solid waste caused by metallurgy, this paper analyses the necessity of metallurgical slag utilization and carries out the research on the current situation of utilization of metallurgical slag generated in the process of ferrous metallurgy, and finally it puts forward the design concept for the comprehensive utilization of metallurgical slag, so as to achieve the high efficient utilization of metallurgical slag.
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- 2012
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21. Research on Properties of Rock-Mineral Wool as Thermal Insulation Material for Construction
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Shu Juan Yang and Li Wei Zhang
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Materials science ,Waste management ,Wool ,Thermal insulation ,business.industry ,Mineral wool ,General Engineering ,Slag (welding) ,business ,Civil engineering ,Efficient energy use - Abstract
Rock wool and slag wool pertain to the same kind of thermal insulation material, which can be produced in quantity and widely used, by comparison with other inorganic fiber thermal insulation materials, thus it is one of the most important thermal insulation material for the national economic development in our country. After the implementation of Civil Construction Energy Efficiency Management Regulation, it puts forward higher requirements for the energy saving standard of new buildings, thus the application prospect of rock-mineral wool thermal insulation material is promising. This paper mainly presents the source of rock-mineral wool, its main relative merits as well as its application in the construction field, moreover, the application and development potential of rock-mineral wool as the thermal insulation material for building wall construction.
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- 2012
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22. The Combined Application of Intermittent Strengthening Strip and After-Irrigation-Strip in Certain Long Concrete Structure
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Lu Yao Ding, De Hu Yu, Sheng Min Ji, Shu Juan Yang, Ying Hao Du, and Tao Sui
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Structure (mathematical logic) ,Engineering ,Closure (computer programming) ,business.industry ,General Engineering ,Quality control ,Economic analysis ,business ,Civil engineering - Abstract
Long concrete structure is frequently used in modern buildings or structures. As the main measures of achieving seamless construction and crack control of long concrete structure, strengthening strip and after-irrigation-strip have been widely applied. However, compared with after-irrigation-strip, the clear advantage of strengthening strip is closure ahead. Therefore, this paper from aspects of theoretical analysis and engineering application replace the after-irrigation-strip with intermittent strengthening strip in one original design of a project. Since the completion of construction, there are no harmful cracks in the structure. This article also describes the project quality control measures and technical and economic analysis for the design and construction of similar projects.
- Published
- 2011
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23. Microcalorimetric Studies on the CMC and Thermodynamic Functions of a Nonionic Surfactant (Tween80) in DMF/Long-Chain Alcohol Systems from T=298.15 to T=313.15 K
- Author
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Shu-juan Yang, Chang-qing Kong, Hong-yan Bi, Honglin Zhang, and Jing Li
- Subjects
Isothermal microcalorimetry ,Biophysics ,Alcohol ,Biochemistry ,Micelle ,Solvent ,chemistry.chemical_compound ,chemistry ,Organic chemistry ,Physical chemistry ,Nonionic surfactant ,Titration ,Physical and Theoretical Chemistry ,Carbon number ,Molecular Biology ,Long chain - Abstract
The power-time curves of the micelle formation process were determined for the nonionic surfactant Tween80/nonaqueous solvent (DMF)/long-chain alcohol (n-heptanol, n-octanol, n-nonanol, and n-decanol) systems by titration microcalorimetry at temperatures of (298.15, 303.15, 308.15, and 313.15) K. From the power-time curves, the CMC and \(\Delta H_{\mathrm{m}}^{\uptheta}\) values were obtained. The corresponding values of \(\Delta G_{\mathrm{m}}^{\uptheta}\) and \(\Delta S_{\mathrm{m}}^{\uptheta}\) were also calculated. The relationships of the CMC with the carbon number of the alcohol, the concentration of alcohol, and the temperature, along with the thermodynamic functions, are discussed.
- Published
- 2011
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- View/download PDF
24. Microcalorimetric Studies on the Critical Micelle Concentration and Thermodynamic Functions of the Poly(oxyethylene) Lauryl Ether and Poly(oxyethylene glycol) Octylphenyl Ether in N,N-Dimethylformamide + Long-Chain Alcohol Systems at 298.15 K
- Author
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Chang-qing Kong, Li Yu, Ke Zhang, Shu-juan Yang, Gan-Zuo Li, and Honglin Zhang
- Subjects
Isothermal microcalorimetry ,chemistry.chemical_compound ,Chemistry ,General Chemical Engineering ,Critical micelle concentration ,Thermodynamics of micellization ,Polymer chemistry ,Dimethylformamide ,Ether ,Alcohol ,Titration ,General Chemistry ,Micelle - Abstract
The power−time curves of the micelle formation process are determined for the nonionic surfactants (Brij-35 and TX-100) in dimethylformamide (DMF) + long-chain alcohol systems by titration microcalorimetry. From the power−time curves, the critical micelle concentration (cmc) and the ΔHθm are obtained with ΔGθm and ΔSθm calculated. For this system, the relationships among the alcohol carbon number, the alcohol concentration with cmc, and the thermodynamic functions are discussed.
- Published
- 2010
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25. Phylogeography of ground tit (Pseudopodoces humilis) based on mtDNA: Evidence of past fragmentation on the Tibetan Plateau
- Author
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Zuo-Hua Yin, Xin-Ming Ma, Fumin Lei, and Shu-Juan Yang
- Subjects
Male ,Population ,Biology ,Tibet ,DNA, Mitochondrial ,Altitude ,Genetics ,Animals ,Passeriformes ,Glacial period ,education ,Molecular Biology ,Phylogeny ,Ecology, Evolution, Behavior and Systematics ,Isolation by distance ,Population Density ,mtDNA control region ,education.field_of_study ,geography ,Plateau ,geography.geographical_feature_category ,Base Sequence ,Geography ,Ecology ,Genetic Variation ,Locus Control Region ,biology.organism_classification ,Phylogeography ,Phenotype ,Ground tit ,Female ,Sequence Alignment - Abstract
Pseudopodoces humilis, a long misclassified terrestrial tit, is the only species of parid whose distribution is limited to treeless terrain and endemic to the Tibetan Plateau. We revealed the phylogeographic structure of the species by using mitochondrial control region, as well as comparing morphological characters. The distinct geographic distributions of two major clades suggest spatial and temporal separations that coincide with important climatic and paleogeographic changes following the uplift of the Tibetan Plateau. Population expansion was inferred for the population at the platform of the Plateau 0.17 million years before present (Ma B.P.), and restricted gene flow with isolation by distance was detected within this region, congruent with expansion occurring after the extensive glacial period. A significant decrease in body size with decreasing altitude was found, possibly indicating selection for larger-sized birds at higher altitude.
- Published
- 2006
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26. ChemInform Abstract: A Convenient and Simple Synthesis of Densely Functionalized Cyclopenta[cd]azulenes and Cyclopenta[ef]heptalenes
- Author
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Chien-Kuo Ku, Jun-Xiong Chen, Ling-Yu Cheng, Shu-Juan Yang, Chi-Phi Wu, and Badugu Devendar
- Subjects
chemistry.chemical_compound ,Stereochemistry ,Chemistry ,Simple (abstract algebra) ,General Medicine ,Tropolone - Abstract
Cyclopenta[cd]azulenes (III), (VI), (XIII), 1,2-dihydrocyclopenta[c,d]azulenes (V), (XII), and cyclopenta[ef]heptalenes (X), (XV), (XVI) are obtained by simple reactions starting from tropolone.
- Published
- 2014
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27. [Chemical constituents of pattra medicine Euodia lepta]
- Author
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Guo-jiao, Kang, Shu-juan, Yang, Hai-yu, Zhou, Zeng-ming, Yang, and Ling-yun, Chen
- Subjects
Plant Leaves ,China ,Coumaric Acids ,Plant Stems ,Furocoumarins ,Dioxoles ,Sitosterols ,Lignans ,Evodia - Abstract
To study the chemical constituents of Pattra Medicine Euodia lepta in Xishuangbanna of Yunnan Province.The chemical constituents were isolated and purified by chromatographic techniques, and identified by NMR, MS and other spectral methods.In 60% ethanol extract from the stems,and 95% ethanol extract from the leaves, six compounds and two compounds were isolated and identified as pachypodol( 1) ,3-(3-methyl-but-2-enyl )umbelliferone(2),7-demethylsuberosin (3),beta-sitosterol (4),3,7-dimethoxy kaempferol(5), euolitrine(6), sesamin(7) and p-O-geranyl coumaric acid(8), respectively.Compound 7 is obtained from Euodia genus for the first time,and compound 8 is obtained from domestic Euodia lepta for the first time.
- Published
- 2014
28. Association of GSTTI and GSTM1 variants with acute myeloid leukemia risk
- Author
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D. Ma, M. Yang, Youmei Zi, Sun Wu, C. Yang, Shu-Juan Yang, and Yan Huang
- Subjects
Adult ,Male ,Genotype ,Biology ,law.invention ,GSTP1 ,law ,Risk Factors ,Genetics ,Humans ,Genetic Predisposition to Disease ,Allele ,neoplasms ,Molecular Biology ,Genotyping ,Polymerase chain reaction ,Alleles ,Glutathione Transferase ,Acute leukemia ,integumentary system ,Myeloid leukemia ,General Medicine ,Odds ratio ,Middle Aged ,Leukemia, Myeloid, Acute ,Glutathione S-Transferase pi ,Case-Control Studies ,Immunology ,Female - Abstract
We aimed to investigate the relationships between polymorphisms of the glutathione S-transferases (GSTs) GSTM1, GSTTI, and GSTP1 and the risk of developing acute myeloid leukemia (AML). A total of 206 AML cases and 231 controls were collected for our study. The genotyping of GSTs (GSTM1, GSTTI, and GSTP1) was based upon the duplex polymerase chain reaction with the confronting two- pair primer (PCR-CTPP) method. Individuals carrying null GSTTI and GSTM1 genotypes had a 1.52- and 1.78-fold increased risk of developing acute leukemia, respectively, compared to non-null genotype carriers (P < 0.05). A high risk was observed in those carrying a combination of null genotypes of GSTM1 and GSTTI with GSTP1-Val allele genotypes when compared with those carrying wild-type genotypes, with an odds ratio (95% confidence interval) of 3.62 (1.53-8.82) (P < 0.05). These findings indicate that genetic variants of GSTTI and GSTM1 significantly increase the risk of developing AML. Our study offers important insights into the molecular etiology of AML.
- Published
- 2014
29. Interleukin-4 and -8 gene polymorphisms and risk of gastric cancer in a population in Southwestern China
- Author
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Hui Lan, Ying Wen, Chun-Xia Yang, Feng Chen, Shu-Juan Yang, Yuan-Yuan Wen, Xiong-Fei Pan, Richie Soong, He Huang, Zhi-Mei Zhao, Zhi Tian, and Marie Loh
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,China ,Epidemiology ,Population ,Single-nucleotide polymorphism ,Bioinformatics ,Gastroenterology ,Polymorphism, Single Nucleotide ,Gene Frequency ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Surveys and Questionnaires ,Genotype ,Medicine ,Humans ,Family ,Genetic Predisposition to Disease ,Family history ,education ,Gene ,Interleukin 4 ,Genetic Association Studies ,Whole blood ,Demography ,education.field_of_study ,business.industry ,Interleukin-8 ,Public Health, Environmental and Occupational Health ,Case-control study ,Cardia ,Middle Aged ,Oncology ,Case-Control Studies ,Female ,Interleukin-4 ,business - Abstract
Gastric carcinogenesis is a complicated process that involves environmental and genetic factors like interleukin-4 (IL-4) and IL-8. Single nucleotide polymorphisms in their genes are associated with changed levels of gene expression. Here, we investigated the association between IL4-590 CT and IL8-251TA and gastric cancer (GC) risk in Sichuan of Southwestern China.We surveyed the research subjects using a self-designed questionnaire with questions on demographic factors and putative risk factors. Approximately 2-5ml of whole blood was collected after field survey to analyze IL4-590 CT and IL8-251TA genotypes using MALDI-TOF MS.Our study recruited 308 pairs of GC patients and controls, including 224 (72.7%) men and 84 (27.3%) women in each group. There were 99 cardia and 176 noncardia GC patients in the case group. The case and control groups had an average age of 57.7±10.6 (mean±SD) and 57.6±11.1 years. GC patients reported a significantly greater proportion of family history of cancer (29.9% vs 10.7%, p0.01) and drinking (54.6% vs 43.2%, p0.01) than did controls. Variant genotypes of IL-4-590 CT and IL-8-251 TA were not associated with overall GC risk (adjusted OR, 0.89; 95%CI, 0.61-1.28 for CT or CC vs TT; adjusted OR, 1.14; 95%CI, 0.86-1.79 for TA or AA vs TT). Stratification analysis of two SNPs for risk by subsites only found that variant IL-8-251 TA or AA genotype was associated with increased noncardia GC risk (adjusted OR, 2.58; 95%CI, 1.19-5.57). We did not observe interactions between the IL-8-251 TA genotype and smoking (adjusted OR, 0.38; 95%CI, 0.08-1.79) or drinking (adjusted OR, 0.36; 95%CI, 0.08-1.65) for risk of noncardia GC.Our data indicate no association between the two SNPs of IL-4-590 and IL-8-251 with overall GC risk, while the IL-8-251 TA or AA genotype conferred risk of cardia GC. Our findings contribute to the evidence body for risk of SNPs associated with the development of gastric cancer in this region.
- Published
- 2014
30. Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: a meta-analysis of case-control studies
- Author
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Jian-Xing Zhang, Xin-Yue Chen, Yuan-Yuan Wen, and Shu-Juan Yang
- Subjects
Cancer Research ,medicine.medical_specialty ,Pathology ,Esophageal Neoplasms ,Genotype ,Epidemiology ,Biology ,Gastroenterology ,Polymorphism, Single Nucleotide ,Pathogenesis ,Folic Acid ,Risk Factors ,Internal medicine ,medicine ,Confidence Intervals ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Methylenetetrahydrofolate Reductase (NADPH2) ,Public Health, Environmental and Occupational Health ,Case-control study ,Odds ratio ,Esophageal cancer ,medicine.disease ,digestive system diseases ,Confidence interval ,Diet ,Oncology ,Meta-analysis ,Methylenetetrahydrofolate reductase ,Case-Control Studies ,biology.protein ,Carcinoma, Squamous Cell - Abstract
BACKGROUND Genetic factors and environmental factors play a role in pathogenesis of esophageal squamous cell carcinoma (ESCC). Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk. METHODS MEDLINE, EMBASE and the Chinese Biomedical Database were searched in our study. The quality of studies were evaluated by predefined scale, and The association of polymorphisms of MTHFR C677T and folate intake and ESCC risk was estimated by Odds ratio (ORs) with 95% confidence intervals (CIs). RESULTS 19 studies (4239 cases and 5575 controls) were included for meta-analysis. A significant association was seen between individuals with MTHFR 677 CT [OR(95%)=1.47(1.32-1.63)] and TT [OR(95%)=1.69(1.49-1.91)] genotypes and ESCC risk (p
- Published
- 2013
31. Screening for oesophageal cancer
- Author
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Siying Wu, Xiao Y Chen, Shu-Juan Yang, Xin-Yue Chen, Yuan-Yuan Wen, Yuchuan Huang, Jianwei Zheng, Liu Xian, Ying Shao, Chunxia Yang, and Huangyuan Li
- Subjects
medicine.medical_specialty ,Esophageal Neoplasms ,MEDLINE ,Cochrane Library ,Adenocarcinoma ,Asymptomatic ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Carcinoma ,Humans ,Pharmacology (medical) ,Staining and Labeling ,business.industry ,Incidence (epidemiology) ,Cancer ,medicine.disease ,Surgery ,Carcinoma, Squamous Cell ,Esophagoscopy ,medicine.symptom ,business ,Iodine - Abstract
Background Oesophageal cancer is a global heath problem. The prognosis for advanced oesophageal cancer is generally unfavourable, but earlystage asymptomatic oesophageal cancer is basically curable and could achieve better survival rates. The two most commonly used tests are cytologic examination and endoscopy with mucosal iodine staining. The efficacy of the screening tests is controversial, and the true benefit and efficacy of screening remains uncertain because of the potential lead-time and length-time biases. This review was conducted to examine the evidence for the efficacy of screening for oesophageal cancer (squamous cell carcinoma and adenocarcinoma). Objectives To determine the efficacy of early screening, using endoscopy with iodine staining or cytologic examination, in reducing mortality from oesophageal cancer in asymptomatic individuals from high-risk and general populations. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2012, Issue 8), The Cochrane Library (2012, Issue 8), MEDLINE (1950 to August 2012), EMBASE (1980 to August 2012), Allied and Complementary Medicine (AMED) (1985 to August 2012), Chinese Biomedical Database (CBM) (January 1975 to August 2012), VIP Database (January 1989 to August 2012), China National Knowledge Infrastructure (CNKI) (January 1979 to August 2012), and the Internet. We also searched reference lists, conference proceedings, and databases of ongoing trials. There was no restriction on language or publication status in the search for trials. Selection criteria We included only randomised controlled trials (RCT) of screening versus no screening for oesophageal cancer. Randomisation of groups or clusters of individuals was acceptable. Data collection and analysis Two review authors independently scanned the titles and abstracts from the initial search for potential trials for inclusion. We did not find any trials that met the inclusion criteria. Main results The electronic search identified 3482 studies. Two authors independently reviewed the references. The reports of 18 studies were retrieved for further investigation. Nonemet the eligibility criteria for a RCT investigation of the effects of screening versus no screening for oesophageal cancer. Authors conclusions There were no RCTs that determined the efficacy of screening for oesophageal cancer. Non-RCTs showed a high incidence and the reported better survival after screening could be caused by selection bias, lead-time and length-time biases. RCTs are needed to determine the efficacy of screening for oesophageal cancer.
- Published
- 2012
32. Traditional Chinese medicinal herbs for condyloma acuminatum
- Author
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Yuchuan Huang, Shu-Juan Yang, Taixiang Wu, Hao Wu, Jianwei Zheng, and Xiao Y Chen
- Subjects
Traditional medicine ,business.industry ,Medicinal herbs ,Medicine ,Pharmacology (medical) ,Condyloma Acuminatum ,business - Published
- 2012
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33. Systematic review on Epstein-Barr virus (EBV) DNA in diagnosis of nasopharyngeal carcinoma in Asian populations
- Author
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Hui Wang, Xiang-Ying Xu, Bao-Lin Han, Guang-Shun Wang, Shu-Juan Yang, Chun-Feng Han, Jian-Juan Wu, Xuan Wang, Chun-Zhi Zhang, and Yao Xie
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,China ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Epidemiology ,Biology ,medicine.disease_cause ,Cohort Studies ,Internal medicine ,medicine ,Humans ,Mass Screening ,Prospective Studies ,Antigens, Viral ,Nasopharyngeal cancer ,Nasopharyngeal Carcinoma ,Receiver operating characteristic ,Carcinoma ,Public Health, Environmental and Occupational Health ,Cancer ,Nasopharyngeal Neoplasms ,medicine.disease ,Thailand ,Epstein–Barr virus ,Nasopharyngeal carcinoma ,Case-Control Studies ,Immunology ,DNA, Viral ,Asian population ,Cohort study - Abstract
Objective: To conduct a meta-analysis to investigate the value of EBV DNA in diagnosis of nasopharyngeal cancer (NPC) in Asian populations, and provide important evidence for screening. Methods: Prospective or respective case-control or cohort studies regarding the detection role of EBV DNA for NPC were included in our study. We conducted a comprehensive literature search in PubMed, EMBASE, and the Chinese Biomedical Database (CBM database between January 1980 and March 2012. Results: A total of 18 studies with 1492 NPC cases and 2641 health controls were included. Almost of the included studies were conducted in China, and only one other conducted in Thailand. The overall results demonstrated that the pooled sensitivity, specificity, positive likelihood (+LR) and negative likelihood (-LR) were 0.73 (0.71-0.75), 0.89 (0.88-0.90), 8.84 (5.65-13.84) and 0.19(0.11-0.32), respectively. The overall EBV DNA detection showed the largest area of 0.932 under the summary receiver operator curve (SROC). The accuracy of detection by plasma for NPC (0.86) was higher than in serum (0.81), with largest areas under the SROC of 0.97 and 0.91, respectively. Conclusion: Our results demonstrated the EBV DNA detection in plasma or serum has high sensitivity and specificity in diagnosis of NPC, especially in Chinese populations with a high risk of cancer.
- Published
- 2012
34. Meta-analysis of the association between GSTM1 and GSTT1 gene polymorphisms and cervical cancer
- Author
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Yao Xie, Rong Wu, Shu-Juan Yang, Xue-Ying Jin, Rui Xing, Li-Na Wu, and Zhen-Yong Zhang
- Subjects
Oncology ,Risk ,Cancer Research ,medicine.medical_specialty ,Pathology ,Genotype ,Epidemiology ,Uterine Cervical Neoplasms ,Subgroup analysis ,Polymorphism, Single Nucleotide ,Internal medicine ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Glutathione Transferase ,Cervical cancer ,business.industry ,Smoking ,Public Health, Environmental and Occupational Health ,Case-control study ,Odds ratio ,medicine.disease ,Confidence interval ,Increased risk ,Meta-analysis ,Case-Control Studies ,Female ,business - Abstract
Aim: We conducted a meta-analysis to analyze the influence of GSTM1 and GSTT1 gene polymorphisms on cervical cancer risk, and explore gene-environment interactions. Methods: Identification of relevant studies was carried out through a search of Medline and the EMbase up to Oct. 2011. All case-control studies that investigated the association between GSTM1 and GSTT1 gene polymorphisms and risk of cervical cancer were included. The pooled odds ratio (OR) was used for analyses of results and the corresponding 95% confidence intervals (CI) were estimated. Results: A total of 21 case-control studies were included in the meta-analysis of GSTM1 (2,378 cases and 2,639 controls) and GSTT1 (1,229 cases and 1,223 controls) genotypes. The overall results showed that the GSTM1 null was related to an increased risk of cervical cancer (OR=1.50, 95% CI=1.21-1.85). Subgroup analysis were performed based on smoking and ethnicity. Our results showed that smokers with null GSTM1 genotype had a moderate increased risk of cervical cancer (OR=1.85, 95% CI=1.07-3.20). For the ethnicity stratification, moderate significantly increased risk of null GSTM1 genotype was found in Chinese (OR=2.12, 95% CI=1.43-3.15) and Indian populations (OR=2.07, 95% CI=1.49-2.88), but no increased risk was noted in others. Conclusion: This meta-analysis provided strong evidence that the GSTM1 genotype is associated with the development of cervical cancer, especially in smokers, and Chinese and Indian populations. However, no association was found for GSTT1 null genotype carriers.
- Published
- 2012
35. [Effects of desulfurization waste on calcium distribution, Ca(2+)-ATPase activity, and antioxidant characteristics of rice leaf under alkali stress]
- Author
-
Gui-Lian, Mao, Xing, Xu, Jin, Zeng, Zi-Hui, Yue, and Shu-Juan, Yang
- Subjects
Plant Leaves ,Soil ,Stress, Physiological ,Superoxide Dismutase ,Calcium ,Oryza ,Calcium-Transporting ATPases ,Alkalies ,Calcium Sulfate ,Ecosystem - Abstract
To approach the action mechanisms of desulfurization waste on alleviating alkali stress-induced injury of rice, a pot experiment was conducted to study the variations of leaf total calcium content, calcium distribution, plasma membrane Ca(2+)-ATPase activity, and reactive oxygen content of rice seedlings under alkali stress after the application of desulfurization waste. In the control, a few calcium particulates scattered in the cell wall and chloroplasts, while applying desulfurization waste or CaSO4 increased the calcium particulates in the plasma membrane, intercellular space, cell wall, and vacuole significantly. With the increasing application rate of desulfurization waste or CaSO4, the leaf total calcium content increased, Ca(2+)-ATPase activity in plasma membrane and tonoplast presented an increasing trend, plasma membrane relative permeability, MDA content, and O2 production rate decreased, and SOD and POD activities increased. The desulfurization waste could relieve the alkali stress to rice in some extent, and the main reactive compound in the waste could be CaSO4.
- Published
- 2012
36. A comparison of the effect of work stress on burnout and quality of life between female nurses and female doctors
- Author
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Huangyuan Li, Shu-Juan Yang, Xiaorong Wang, Hong Qiu, and Siying Wu
- Subjects
Adult ,medicine.medical_specialty ,China ,Adolescent ,Health, Toxicology and Mutagenesis ,education ,Job burnout ,Nurses ,Burnout ,Toxicology ,Chinese version ,Physicians, Women ,Young Adult ,Quality of life (healthcare) ,Surveys and Questionnaires ,medicine ,Humans ,Burnout, Professional ,General Environmental Science ,business.industry ,Stressor ,Public Health, Environmental and Occupational Health ,Middle Aged ,Health Surveys ,Work stress ,Family medicine ,Quality of Life ,Cluster sampling ,Female ,Occupational stress ,business ,psychological phenomena and processes ,Stress, Psychological ,Clinical psychology - Abstract
The objective of this study was to compare the effect of work stress on job burnout and quality of life between female nurses and doctors in China. The participants were 947 female nurses and 685 female doctors selected from Fujian provinces by using stratified cluster sampling method. The Chinese version of Short Form-36 Health Survey was used to measure quality of life; the Occupation Stress Inventory-Revised Edition was applied for occupational stress; and the Maslach Burnout Inventory-General Survey was used to assess job burnout. Occupational stress (indicated by different stressors) played an important role in job burnout and quality of life among female nurses and female doctors when taking into account other potential influencing factors simultaneously. These results show that it is important to adopt different preventive measures to prevent burnout and improve quality of life among the 2 populations according to the different stressors.
- Published
- 2011
37. [Studies on the changes of chemical constituent in Inula nervosa during the processing]
- Author
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Shu-Juan, Yang, Zeng-Ming, Yang, Hai-Yu, Zhou, and Yue-Ping, Tan
- Subjects
Plants, Medicinal ,Time Factors ,Oils, Volatile ,Solvents ,Temperature ,Technology, Pharmaceutical ,Furaldehyde ,Inula ,Plant Roots ,Chromatography, High Pressure Liquid ,Drugs, Chinese Herbal - Abstract
To research the changes of chemical constituent in Inula nervosa during the processing.Inula nervosa processed with different conditions was determined by HPLC,with acetonitrile--water as a mobile phase using gradient elution, and the detective wavelength was 280 nm. The emerging compounds 1 was extracted by 50% ethanol, isolated and purified using chromatography, and identified according to the physicochemical properties and spectral analysis.The HPLC chromatogram of lnula nervosa changes before and after processing. A monomer compounds was isolated from processed Inula nervosa. It was Identified as 5-hydroxymethylfurfural.The chemical constituent of Inula nervosa changes during the processing. It is the first time that compound 1 were isolated from Inula.
- Published
- 2011
38. [Effect of Fructus Gardeniae-zhizi on isolated gastric muscle strips in rabbits]
- Author
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Shu-juan, Yang
- Subjects
Cholagogues and Choleretics ,Stomach ,Animals ,Muscle, Smooth ,Rabbits ,In Vitro Techniques ,Gardenia ,Drugs, Chinese Herbal ,Muscle Contraction - Published
- 2010
39. The mediating and moderating role of personal strain and coping resource in the relationship between work stressor and quality of life among Chinese nurses
- Author
-
Wei Zhu, Xiaorong Wang, Shu-Juan Yang, Huangyuan Li, and Siying Wu
- Subjects
Adult ,Male ,Coping (psychology) ,China ,Adolescent ,Nurses ,Structural equation modeling ,Young Adult ,Adaptation, Psychological ,Humans ,Workplace ,Burnout, Professional ,Stressor ,Multilevel model ,Coping resources ,Public Health, Environmental and Occupational Health ,Middle Aged ,Moderation ,Occupational Diseases ,Work stress ,Total effects ,Quality of Life ,Female ,Psychology ,Stress, Psychological ,Clinical psychology - Abstract
To determine whether personal strain and coping resources act as either mediator or moderator or both in the relationship between work stressor and quality of life among Chinese nurses. A total of 1,012 nurses were selected from eight hospitals located in two provinces in China. Quality of life was measured with the Chinese version of the Short Form-36 Health Survey; work stressor, personal strain, and coping resources were evaluated using the Occupation Stress Inventory-Revised Edition. The hierarchical multiple regression procedure and Baron and Kenny’s model of mediation were applied to test for moderation and mediation, respectively. A structural equation model was fit to assess the interrelationships among these variables. Work stressor was closely associated with quality of life, which was mediated and moderated by personal strain and coping resources. Personal strain also acted both as moderator and mediator in the relationship between coping resources and quality of life. The relationships were verified in the structural equation model. The greatest absolute value of the standardized total effects was seen in personal strain (0.817), followed by work stressor (0.634) and coping resources (0.488). Personal strain and coping resources have both mediating and moderating effects on the relationship between work stress and quality of life in a sample of Chinese nurses. An effective intervention strategy is needed to reduce work stress and ensure better quality of life.
- Published
- 2010
40. Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis
- Author
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Jie Wang, Yu Liu, Tetsuji Yokoyama, Xiao-Qiao Zhou, Ying Shao, Si-Ying Wu, Shu-Juan Yang, Jin Niu, Chun-Xia Yang, Akira Yokoyama, and Yu-Chuan Huang
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,Alcohol Drinking ,Esophageal Neoplasms ,Genotype ,Brief Article ,education ,Taiwan ,Japan ,Risk Factors ,Internal medicine ,medicine ,Humans ,ALDH2 ,Sex Characteristics ,Polymorphism, Genetic ,business.industry ,Aldehyde Dehydrogenase, Mitochondrial ,Gastroenterology ,Case-control study ,Alcohol Dehydrogenase ,ADH1B ,General Medicine ,Odds ratio ,Esophageal cancer ,Aldehyde Dehydrogenase ,medicine.disease ,Confidence interval ,Surgery ,Meta-analysis ,Case-Control Studies ,Carcinoma, Squamous Cell ,Female ,business ,Sex characteristics - Abstract
AIM: To evaluate the contribution of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) polymorphisms to the risk of esophageal cancer. METHODS: Nineteen articles were included by searching MEDLINE, EMBASE and the Chinese Biomedical Database, 13 on ADH1B and 18 on ALDH2. We performed a meta-analysis of case-control studies including 13 studies on ADH1B (cases/controls: 2390/7100) and 18 studies on ALDH2 (2631/6030). RESULTS: The crude odds ratio [OR (95% confidence interval)] was 2.91 (2.04-4.14) for ADH1B*1/*1 (vs ADH1B*2/*2) and 1.32 (1.17-1.49) for ADH1B*1/*2. The crude OR for ALDH2*1/*2 (vs ALDH2*1/*1) was 2.52 (1.76-3.61). ADH1B*1/*1 increased the risk of esophageal cancer among never/rare [1.56 (0.93-2.61)], moderate [2.71 (1.37-5.35)], and heavy drinkers [3.22 (2.27-4.57)]. ADH1B*1/*2 was associated with a modest risk among moderate drinkers [1.43 (1.09-1.87)]. ALDH2*1/*2 increased the risk among never/rare [1.28 (0.91-1.80)], moderate [3.12 (1.95-5.01)], and heavy [7.12 (4.67-10.86)] drinkers, and among ex-drinkers [5.64 (1.57-20.25)]. ALDH2*2/*2 increased the risk among drinkers [4.42 (1.72-11.36)]. ADH1B*1/*1 plus ALDH2*1/*2 was associated with the highest risk for heavy drinkers [12.45 (2.9-53.46)]. The results of the meta-regression analysis showed that the effects of ADH1B*1/*1 and ALDH2*1/*2 increased with the level of alcohol consumption. ALDH2*1/*2 was associated with a high risk among Taiwan Chinese and Japanese drinkers, as opposed to a moderate risk among drinkers in high-incidence regions of Mainland China. ADH1B*1/*1 in heavy drinkers and ALDH2*1/*2 in moderate-to-heavy drinkers was associated with similarly high risk among both men and women. CONCLUSION: ADH1B/ALDH2 genotypes affect the risk of esophageal cancer, and the risk is modified by alcohol consumption, ethnicity, and gender.
- Published
- 2010
41. [Epidemiological investigation on the intermediate hosts of Paragonimus in Ninghai County of Zhejiang Province]
- Author
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Jian-Fa, Liu, Yan, Wu, Zhi-Yuan, Tang, Dan, Meng, Shu-Juan, Yang, and Wen-Wen, Jiang
- Subjects
Male ,China ,Paragonimiasis ,Brachyura ,Snails ,Paragonimus ,Animals ,Female ,Fresh Water ,Host-Parasite Interactions - Abstract
Freshwater crabs and snails were collected from Ninghai County in Zhejiang Province, and examined respectively for Paragonimus metacercariae and cercariae. Among 97 freshwater crabs found, the prevalence was 11.3% (11/97) with a mean intensity of 1 metacercariae per crab. It was 10.2% (5/49) and 20.2% (4/20) in the groups weighted 5-15 g and 15-25 g respectively, with an average intensity of 1, and no metacercariae were found in weight group of 25-35 g. Two positive crabs were found from 20 crabs with a low weight (5 g). Male to female crabs ratio was 2.5:1, and there was no significant difference in prevalence between males [12.7%(7/55)] and females [9.1% (2/22)]. No cercariae or metacercariae were found in 200 snails (Semisulcospira libertino).
- Published
- 2010
42. [ATPase distribution in fertile and sterile anther of a genic male sterile Chinese cabbage]
- Author
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Chao Tian, Xie, Shu Juan, Yang, Ya Nan, Zhang, Lv, Ye, and Hui Qiao, Tian
- Subjects
Adenosine Triphosphatases ,Plant Infertility ,Microscopy, Electron, Transmission ,Animals ,Brassica ,Flowers ,Plant Proteins - Abstract
Lead precipitation technique was used to locate Adenosine Triphosphatase (ATPase) in the fertile and sterile anthers of a genic male sterile Chinese cabbage (Brassica campestris L. ssp. Chinensis Makino var. communis Tsen et Lee),which would help us to understand the relationship between ATPase and sterility of anthers of the cabbage. At megaspore mother cell (MMC) of fertile anther many ATPase reactive precipitates were located in nucleus but few of the precipitates in cytoplasm of the cell. Meantime, some ATPase reactive precipitates also specially appeared in mitochondria of the MMC. After meiosis of MMC, the precipitates in cytoplasm of early microspores increased evidently and then decreased step by step with development. The ATPase reactive precipitates in tapetal cell also increased ultimately in early microspore stage and then decreased with development of anther. When microspore formed a large vacuole, which is late stage of microspore, the ATPase reactive precipitates were located in its mitochondria. After microspores mitosis a few of the ATPase reactive precipitates appeared in pollen grains and tapetal cells. More ATPase reactive precipitates appear in MMC of sterile anther than in fertile anther but fewer of them in mitochondria. Although more ATPase granules appear in abnormal tetrad microspores which degenerate by cytoplasm shrinkage and plasmolysis. The relation between ATPase and male sterility of the cabbage was discussed.
- Published
- 2006
43. [Experimental techniques for ancient DNA research]
- Author
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Shu-juan, Yang, Xu-long, Lai, Xian-hua, Tang, and Gui-lian, Sheng
- Abstract
The development of modern molecular biological techniques makes it possible to study minimum DNA from ancient materials. During past decade,a lot of significant achievements on ancient DNA research have been made in many fields especially in molecular evolutionary biology. The nature of degradation and contamination of ancient DNA from ancient biological materials pose a dominating problem in ancient DNA research. Therefore,the experiments should be modified based on the modern molecular techniques and more factors should be considered when the results are analyzed. In this paper,authors review the general experimental protocols on sampling,extraction and amplification as well as authenticity of ancient DNA.
- Published
- 2005
44. Genetic polymorphisms ofADH2andALDH2association with esophageal cancer risk in southwest China
- Author
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Huai-Gong Chen, Hui-Zhang Du, Xiao-Yan Mu, Hua-Yu Wang, Shu-Juan Yang, Xiao-Qing Li, Can-Jie Zheng, and Chun-Xia Yang
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Alcohol Drinking ,Esophageal Neoplasms ,Genotype ,Logistic regression ,Gastroenterology ,Asian People ,Risk Factors ,Internal medicine ,medicine ,Humans ,Allele ,Alleles ,Aged ,ALDH2 ,Aged, 80 and over ,Polymorphism, Genetic ,Traditional medicine ,business.industry ,Aldehyde Dehydrogenase, Mitochondrial ,Alcohol Dehydrogenase ,Case-control study ,General Medicine ,Odds ratio ,Aldehyde Dehydrogenase ,Middle Aged ,Esophageal cancer ,medicine.disease ,Confidence interval ,Logistic Models ,Case-Control Studies ,Female ,business ,Rapid Communication - Abstract
AIM: To evaluate the impact of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms on esophageal cancer risk. METHODS: One hundred and ninety-one esophageal cancer patients and 198 healthy controls from Yanting County were enrolled in this study. ADH2 and ALDH2 genotypes were examined by polymerase-chain-reaction with the confronting-two-pair-primer (PCR-CTPP) method. Unconditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence interval (95% CI). RESULTS: Both ADH2*1 allele and ALDH2*1/*2 allele showed an increased risk of developing esophageal cancer. The adjusted OR (95% CI) for ADH2*1 allele compared with ADH2*2/*2 was 1.65 (95% CI = 1.02-2.68) and 1.67 (95% CI = 1.02-2.72) for ALDH2*1/*2 compared with ALDH2*1/*1. A significant interaction between ALDH2 and drinking was detected regarding esophageal cancer risk, the OR was 1.83 (95% CI = 1.13-2.95). Furthermore, when compared with ADH2*2/*2 and ALDH2*1/*1 carriers, ADH2*1 and ALDH2*2 carriers showed an elevated risk of developing esophageal cancer among non-alcohol drinkers (OR = 2.46, 95% CI = 0.98-6.14), and a significantly elevated risk of developing esophageal cancer among alcohol drinkers among alcohol drinkers (OR = 9.86, 95% CI = 3.10-31.38). CONCLUSION: ADH2 and ALDH2 genotypes are associated with esophageal cancer risk. ADH2*1 allele and ALDH2*2 allele carriers have a much higher risk of developing esophageal cancer, especially among alcohol drinkers.
- Published
- 2007
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