151 results on '"Shiqiang Yu"'
Search Results
2. Chemical mechanical polishing of silicon wafers using developed uniformly dispersed colloidal silica in slurry
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Wenxiang Xie, Zhenyu Zhang, Li Wang, Xiangxiang Cui, Shiqiang Yu, Hongjiu Su, and Shudong Wang
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Strategy and Management ,Management Science and Operations Research ,Industrial and Manufacturing Engineering - Published
- 2023
3. Dual-plasmon-enhanced nitrophenol hydrogenation over W18O49–Au heterostructures studied at the single-particle level
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Yayang Xu, Shiqiang Yu, Fengxia Tong, Zeyan Wang, Peng Wang, Yuanyuan Liu, Hefeng Cheng, Yuchen Fan, Wei Wei, Ying Dai, Zhaoke Zheng, and Baibiao Huang
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Catalysis - Abstract
The dual-plasmonic W18O49–Au heterostructure exhibited enhanced catalytic performance in nitrophenol hydrogenation. The HEI process and coupling effect were demonstrated by single-particle spectroscopy and FDTD simulation.
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- 2023
4. Spontaneous Valley Polarization in a Ferromagnetic Fe(OH)2 Monolayer
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Yushuo Xu, Shuhua Wang, Shiqiang Yu, Xinxin Wang, Baibiao Huang, Ying Dai, and Wei Wei
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General Materials Science ,Physical and Theoretical Chemistry - Published
- 2022
5. Spontaneous Valley Polarization Caused by Crystalline Symmetry Breaking in Nonmagnetic LaOMX2 Monolayers
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Yushuo Xu, Yuanyuan Wang, Shuhua Wang, Shiqiang Yu, Baibiao Huang, Ying Dai, and Wei Wei
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Mechanical Engineering ,General Materials Science ,Bioengineering ,General Chemistry ,Condensed Matter Physics - Published
- 2022
6. Characterization of the Dynamic Changes of Ruminal Microbiota Colonizing Citrus Pomace Waste during Rumen Incubation for Volatile Fatty Acid Production
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Shiqiang Yu, Liuxue Li, Huiying Zhao, Yan Tu, Ming Liu, Linshu Jiang, and Yuchao Zhao
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Microbiology (medical) ,Infectious Diseases ,General Immunology and Microbiology ,Ecology ,Physiology ,Genetics ,Cell Biology - Abstract
As a natural fermentation system, the rumen ecosystem of ruminants can efficiently degrade plant cellulose, indicating that the rumen microbiome offers an opportunity for anaerobic digestion to utilize biomass wastes containing cellulose. Knowledge of the response of the in situ microbial community to citrus pomace during anaerobic fermentation will help improve the current understanding of citrus biomass waste utilization.
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- 2023
7. Excited-State Properties of CuInP2S6 Monolayer as Photocatalyst for Water Splitting
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Hongling Liu, Shiqiang Yu, Yuanyuan Wang, Baibiao Huang, Ying Dai, and Wei Wei
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General Materials Science ,Physical and Theoretical Chemistry - Published
- 2022
8. Effect of cations on the improvement of material removal rate of silicon wafer in chemical mechanical polishing
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Wenxiang Xie, Zhenyu Zhang, Xin Chen, Shiqiang Yu, Chunjing Shi, Hongxiu Zhou, and Wei Wen
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Colloid and Surface Chemistry - Published
- 2023
9. A new concept of atomically thin p–n junction based on Ca2N/Na2N donor–acceptor heterostructure: a first-principles study
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Shiqiang Yu, Baibiao Huang, Ying Dai, and Wei Wei
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General Materials Science - Abstract
In this work, we propose a new concept for atomically thin p–n junction with a natural Ohmic contact based on the Ca2N/Na2N donor–acceptor heterostructure, where Ca2N and Na2N monolayers act as n- and p-type regions, respectively, and the interlayer vacuum plays the role of the depletion region.
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- 2022
10. Unprecedented atomic surface of silicon induced by environmentally friendly chemical mechanical polishing
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Xiangxiang Cui, Zhenyu Zhang, Shiqiang Yu, Xin Chen, Chunjing Shi, Hongxiu Zhou, Fanning Meng, Jiaxin Yu, and Wei Wen
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General Materials Science - Abstract
Schematic diagram of the CMP polishing mechanism for silicon.
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- 2023
11. Ohmic contacts of the two-dimensional Ca2N/MoS2 donor–acceptor heterostructure
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Xinxin Wang, Shiqiang Yu, Yushuo Xu, Baibiao Huang, Ying Dai, and Wei Wei
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General Physics and Astronomy ,Physical and Theoretical Chemistry - Abstract
An excellent n-type Ohmic contact forms between electrene Ca2N and semiconducting MoS2 monolayers, with a 100% tunneling probability and a perfect linear I–V curve.
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- 2023
12. Fungicides-Triggered Tricarboxylic Acid Cycle Response in Pathogenic Fungus Botrytis cinerea Identified by Ion Chromatography
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Shaorong Luan, Shiqiang Yu, Danni Cai, Xiaowei Wang, Lijun Ni, Dandan Zhang, Chang Hou, and Qingchun Huang
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2023
13. Dietary citrus flavonoid extract improves lactational performance through modulating rumen microbiome and metabolites in dairy cows
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Shiqiang Yu, Liuxue Li, Huiying Zhao, Shuyue Zhang, Yan Tu, Ming Liu, Yuchao Zhao, and Linshu Jiang
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General Medicine ,Food Science - Abstract
The effects of dietary supplementation with citrus flavonoid extract (CFE) on milk performance, rumen fermentation, rumen microbiome, rumen metabolome, and serum antioxidant indexes were evaluated. Eight multiparous lactating cows were allocated to a replicated 4 × 4 Latin square with 25-d periods consisting of 20 d of adaptation and 5 d of sampling. Experimental treatments included a control diet (CON) and CON supplemented with 50 g d
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- 2022
14. Spontaneous Valley Polarization in a Ferromagnetic Fe(OH)
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Yushuo, Xu, Shuhua, Wang, Shiqiang, Yu, Xinxin, Wang, Baibiao, Huang, Ying, Dai, and Wei, Wei
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At present, creating sizable spontaneous valley polarization is at the center of the study of valleytronics, which, however, is still a huge challenge. In this work, we determined that the ferromagnetic Fe(OH)
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- 2022
15. Spontaneous Valley Polarization Caused by Crystalline Symmetry Breaking in Nonmagnetic LaOMX
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Yushuo, Xu, Yuanyuan, Wang, Shuhua, Wang, Shiqiang, Yu, Baibiao, Huang, Ying, Dai, and Wei, Wei
- Abstract
In order to achieve valley polarization, breaking the time-reversal symmetry in two-dimensional hexagonal lattices with inversion asymmetry is the heart of current valleytronic research, which, however, has caused studies to stagnate due to the inevitable drawbacks. In this work, we go beyond the conventional paradigm and demonstrate the novel valley physics caused by lowering the crystalline symmetry instead of breaking the time-reversal symmetry. In particular, we translate our concept into concrete nonmagnetic LaOMX
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- 2022
16. Robust Intrinsic Multiferroicity in a FeHfSe3 Layer
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Shiqiang Yu, Baibiao Huang, Wei Wei, Shuhua Wang, Yuanyuan Wang, Ying Dai, and Haona Zhang
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Materials science ,Condensed matter physics ,Magnetism ,Curie temperature ,Antiferromagnetism ,General Materials Science ,Multiferroics ,Physical and Theoretical Chemistry ,Polarization (waves) ,Ground state ,Néel temperature ,Ferroelectricity - Abstract
As a consequence of the mutually exclusive origins of ferroelectricity and magnetism, multiferroic materials with electromagnetic coupling are rare. In this work, stable two-dimensional FeHfSe3 with experimental accessibility is however demonstrated to harbor robust electromagnetic coupling. FeHfSe3 illustrates spontaneous in-plane polarization of 1.29 × 10-10 C/m, and the energy barrier of 116.54 meV ensures easy switching and a high Curie temperature. In addition, semiconducting FeHfSe3 possesses a stable antiferromagnetic ground state with a Neel temperature of approximately 300 K. In the case of applying strain, ferroelectricity and magnetism coexist stably, and uniaxial tensile strain can effectively enhance the ferroelectricity.
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- 2021
17. High efficiency chemical mechanical polishing for silicon wafers using a developed slurry
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Wenxiang Xie, Zhenyu Zhang, Shiqiang Yu, Li Li, Xiangxiang Cui, Qinming Gu, and Zeyun Wang
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General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Surfaces, Coatings and Films - Published
- 2023
18. Structural engineering brings new electronic properties to Janus ZrSSe and HfSSe monolayers
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Xinxin Wang, Shuhui Zhang, Yuanyuan Wang, Shiqiang Yu, Baibiao Huang, Ying Dai, and Wei Wei
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General Physics and Astronomy ,Physical and Theoretical Chemistry - Abstract
Interfacing effects within emergent two-dimensional (2D) materials are of fundamental interest and are at the center of applications in nanoelectronics. Thus, out-of-plane and in-plane heterostructures as well as electronic heterostructures with phase boundaries and large-angle (60°) grain boundaries (GBs) of Janus ZrSSe and HfSSe are studied in this work using first-principles calculations. The out-of-plane heterostructures of T-ZrSSe and T-HfSSe illustrate quite weak interfacing interactions, thus the electronic properties are, unusually, more like the superposition of individual monolayers. The in-plane heterostructures of T-ZrSSe and T-HfSSe, interestingly, exhibit an indirect-direct band gap transition and type-II band alignment, which correspond to boosted optical properties and spatially separated excitons. For the in-plane electronic heterostructures that are constituted by T-ZrSSe and H-ZrSSe, semiconductor-metal crossover occurs due to the polar discontinuity across the T-H phase boundary, and they behave as one-dimensional metallic wires embedded in otherwise semiconducting Janus ZrSSe, creating a one-dimensional electron/hole gas. This also indicates a strategy for stabilizing the unstable and/or metastable monolayer
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- 2022
19. Mulberry Leaf Extract Improves Metabolic Syndrome by Alleviating Lipid Accumulation In Vitro and In Vivo
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Liangyu He, Yan Xing, Xinxiu Ren, Mengjiao Zheng, Shiqiang Yu, Yinbo Wang, Zhilong Xiu, and Yuesheng Dong
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metabolic syndrome ,mulberry leaf extract ,flavonoids ,lipid metabolism ,gut microbiota ,Metabolic Syndrome ,Plant Extracts ,Organic Chemistry ,Pharmaceutical Science ,Diet, High-Fat ,Lipid Metabolism ,Lipids ,Analytical Chemistry ,Mice ,Liver ,Chemistry (miscellaneous) ,Drug Discovery ,Molecular Medicine ,Animals ,Morus ,Physical and Theoretical Chemistry ,Insulin Resistance - Abstract
Metabolic syndrome (MS) is a metabolic disease with multiple complications. Mulberry leaf extract (MLE) is rich in flavonoids and has great potential in alleviating glucose and lipid metabolism disorders. This study evaluated the effect and mechanism of MLE on the alleviation of MS. The components of the MLE were analyzed, and then the regulation of lipid metabolism by MLE in vitro and in vivo was determined. In a hepatocyte model of oleic acid-induced lipid accumulation, it was found that MLE alleviated lipid accumulation and decreased the expression of genes involved in lipogenesis. Furthermore, MLE improved obesity, insulin resistance, plasma lipid profile, and liver function in MS mice after a 15-week intervention. MLE decreased the expression of SREBP1, ACC, and FAS through the AMPK signaling pathway to inhibit lipid synthesis and increase the level of CPT1A to promote lipid decomposition to achieve its hypolipidemic effect. Meanwhile, MLE was also shown to affect the composition of the gut microbiota and the production of short-chain fatty acids, which contributed to the alleviation of lipid accumulation. Our results suggest that MLE can improve MS by improving lipid metabolism through multiple mechanisms and can be developed into dietary supplements for the improvement of MS.
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- 2022
20. 1-Deoxynojirimycin attenuates septic cardiomyopathy by regulating oxidative stress, apoptosis, and inflammation via the JAK2/STAT6 signaling pathway
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LiQing Jiang, LiYun Zhang, JiaChang Yang, Heng Shi, HanZhao Zhu, MengEn Zhai, LinHe Lu, XiaoWu Wang, Xia Yun Li, ShiQiang Yu, JinCheng Liu, and WeiXun Duan
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Pharmacology ,Lipopolysaccharides ,Inflammation ,1-Deoxynojirimycin ,Heart Diseases ,Apoptosis ,General Medicine ,Janus Kinase 2 ,Antiviral Agents ,Mice ,Oxidative Stress ,Sepsis ,Animals ,Cytokines ,Hypoglycemic Agents ,Reactive Oxygen Species ,Cardiomyopathies ,Signal Transduction ,Janus Kinases - Abstract
Cardiac dysfunction caused by sepsis is the predominant reason for death in patients with sepsis. However, the effective drugs for its prevention and the molecular mechanisms remain elusive. 1-Deoxynojirimycin (DNJ), a natural iminopyranose, exhibits various biological properties, such as hypoglycemic, antitumor, antiviral, and anti-inflammatory activities. However, whether DNJ can mediate biological activity resistance in sepsis-induced myocardial injury and the underlying mechanisms are unclear. Janus kinase and signal transducer and activator of transcription (JAK/STAT) signaling is an important pathway for the signal transduction of several key cytokines in the pathogenesis of sepsis, which can transcribe and modulate the host immune response. This study was conducted to confirm whether DNJ mediates oxidative stress, apoptosis, and inflammation in cardiomyocytes, thereby alleviating myocardial injury in sepsis via the JAK2/STAT6 signaling pathway. Septic cardiomyopathy was induced in mice using lipopolysaccharide (LPS), and they were then treated with DNJ. The results showed that DNJ markedly improved sepsis-induced cardiac dysfunction, attenuated reactive oxygen species generation, reduced cardiomyocyte apoptosis, and mitigated inflammation. Mechanistically, increased JAK2/STAT6 phosphorylation was observed in the mouse sepsis models, which decreased significantly after DNJ oral treatment. To further confirm whether DNJ mediates the JAK2/STAT6 pathway, the selective inhibitor fedratinib was used to block the JAK2 signaling pathway in vitro, which enhanced the protective effects of DNJ against the sepsis-induced cardiac damage. Collectively, these findings suggest that DNJ attenuates sepsis-induced myocardial injury by decreasing myocardial oxidative damage, apoptosis, and inflammation via the regulation of the JAK2/STAT6 signaling pathway.
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- 2022
21. A new concept of atomically thin
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Shiqiang, Yu, Baibiao, Huang, Ying, Dai, and Wei, Wei
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In atomically thin
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- 2022
22. Lipidomic profiling using GC and LC-MS/MS revealed the improved milk quality and lipid composition in dairy cows supplemented with citrus peel extract
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Yuchao Zhao, Shiqiang Yu, Huiying Zhao, Liuxue Li, Yuqin Li, Yan Tu, Linshu Jiang, and Guangyong Zhao
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Citrus ,Plant Extracts ,Phosphatidylethanolamines ,Polyphenols ,Animal Feed ,Antioxidants ,Milk ,Tandem Mass Spectrometry ,Dietary Supplements ,Lipidomics ,Phosphatidylcholines ,Animals ,Lactation ,Cattle ,Female ,Linoleic Acids, Conjugated ,Food Science ,Chromatography, Liquid - Abstract
Eight lactating cows were used to determine the effects of citrus peel extract (CPE) on milk performance, antioxidant properties, and milk lipids composition. CPE supplementation up to 150 g/d (CPE150) increased milk yield and the proportions of unsaturated fatty acids of conjugated linoleic acid. CPE with abundant polyphenol and flavonoids can transfer these bioactive substances to mammary gland and improve the antioxidant properties of milk obtained from cows. Lipidomics revealed that 56 lipid species were altered between CON vs CPE150, and there were five key differential metabolic pathways. In particular, milk phosphatidylethanolamine and phosphatidylcholine were significantly increased with dietary CPE supplementation. In summary, our results provide insights into the modifications in the milk components and milk quality of dairy cows received CPE. The inclusion of CPE in the diet of dairy cows may be an effective and natural way to increase the antioxidant amounts and beneficial lipids in milk.
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- 2022
23. 1-Year Outcomes of a Multicenter Randomized Controlled Trial of the Ankura II Thoracic Endoprosthesis for the Endovascular Treatment of Stanford Type B Aortic Dissections
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Chang Shu, Hao He, Weiguo Fu, Wei Guo, Ming Li, Erping Xi, Shuguang Guo, Xueming Chen, Zhanxiang Xiao, Shiqiang Yu, Jianhua Huang, Xiangchen Dai, Zhiwei Wang, Wei Li, Qingshan Zheng, Quanming Li, Lunchang Wang, Xin Li, Junwei Wang, and Feng Gu
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Cardiology and Cardiovascular Medicine - Abstract
BackgroundThe Ankura II Thoracic Stent Graft System (Lifetech, Shenzhen, China) is an evolution of the Ankura stent graft. This study reports one-year outcomes of the Ankura II Thoracic Stent Graft System for endovascular treatment of Stanford type B aortic dissections.MethodsThe Ankura II Thoracic Aortic Endovascular Trial was a randomized, single-blinded, clinical trial conducted at 12 Chinese institutes. The enrolled patients diagnosed with Stanford type B aortic dissections (TBADs) were randomly assigned to the Ankura group or Ankura II group. Standard follow-up examinations were performed at 1, 6, and 12 months. Safety and efficacy data were analyzed.Results132 patients with TBADs were enrolled. The outcomes for the primary safety end points revealed that the Ankura II stent graft was statistically non-inferior compared to the Ankura stent graft. The 1-month device-related major adverse events (1.6 vs. 0%; p = 0.48), 1-month all-cause mortality (1.7 vs. 4.5%; p = 0.621), 12-month survival rate (95.2 ± 2.7% vs. 94.1 ± 2.9%; p = 0.769), and major adverse event (MAE) rate (5.1 vs. 4.7% at 1 month; p = 0.73 and 5.8 vs. 8.9% at 12 months; p = 0.718) of Ankura II group are all comparable to Ankura group. The two groups showed similar primary effectiveness and true lumen expansion effect, and false lumen remodeling was improved in Ankura II group (−100.0 vs. −48.5%; p = 0.08).ConclusionsThe one-year outcomes from this prospective, randomized, multicenter study demonstrate that Ankura II stent graft shows comparable results to Ankura for treating TBADs, resulting in low mortality rates, MAEs and reintervention rates.Clinical Trial RegistrationChiCTR-TRC-12002844.
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- 2022
24. Excited-State Properties of CuInP
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Hongling, Liu, Shiqiang, Yu, Yuanyuan, Wang, Baibiao, Huang, Ying, Dai, and Wei, Wei
- Abstract
In recent years, two-dimensional (2D) materials of ferroelectricity have been illustrated to have great potential in solar energy conversion processes such as photocatalytic water splitting, although the optical properties of such materials are rarely discussed. In combination with the first-principles calculations, many-body Green's function method was used to obtain the excited-state properties of the representative CuInP
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- 2022
25. Serum Myoglobin Is Associated With Postoperative Acute Kidney Injury in Stanford Type A Aortic Dissection
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Chen, Yang, Peng, Hou, Dongxu, Wang, Zhenguo, Wang, Weixun, Duan, Jincheng, Liu, Shiqiang, Yu, Feng, Fu, and Zhenxiao, Jin
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General Medicine - Abstract
BackgroundThe correlation between rhabdomyolysis and postoperative acute kidney injury has been reported in several surgical procedures. As a good predictor of rhabdomyolysis-related acute kidney injury, an elevated serum myoglobin level was often observed after total aortic arch replacement combined with frozen elephant trunk implantation. However, the correlation between serum myoglobin and acute kidney injury in such patients had not been established.MethodsTotally 398 stanford type A aortic dissection patients who underwent total aortic arch replacement combined with frozen elephant trunk implantation were enrolled in this retrospective study. The correlations between serum myoglobin and acute kidney injury as well as the 30-day mortality were assessed.ResultsOverall, 268(67.3%) patients had acute kidney injury (KDIGO stage 1 or higher) and 75(18.8%) had severe acute kidney injury (KDIGO stage 2&3). Patients who developed acute kidney injury had higher level of perioperative serum myoglobin than patients without acute kidney injury. After adjusting for known acute kidney injury risk factors, logarithmically transformed preoperative serum myoglobin [OR = 1.58 (95% CI, 1.26–1.95), P < 0.001] and postoperative day 1 serum myoglobin [OR = 3.47 (95%CI, 2.27–5.29), P < 0.001] were associated with severe acute kidney injury. These correlation persisted after adjustment for decline in filtration via change in serum creatinine (ΔCr) and biomarkers of cardiac and kidney injury, including N-terminal prohormone of brain natriuretic peptide, cardiac troponin I, creatine kinase-MB, serum creatinine and Cystatin C. Compared with the clinical model, sMb considerably improved the risk discrimination and reclassification for AKI.ConclusionFor stanford type A aortic dissection patients underwent total aortic arch replacement with frozen elephant trunk implantation, serum myoglobin can improve postoperative acute kidney injury risk classification. Rhabdomyolysis may be an important supplement to the existing knowledge on the mechanism of acute kidney injury.
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- 2022
26. Electronic properties of Janus MXY/graphene (M = Mo, W; X ≠ Y = S, Se) van der Waals structures: a first-principles study
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Baibiao Huang, Ying Dai, Fengping Li, Shiqiang Yu, and Wei Wei
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Materials science ,Condensed matter physics ,Graphene ,Schottky barrier ,Exciton ,General Physics and Astronomy ,02 engineering and technology ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Band offset ,0104 chemical sciences ,law.invention ,Condensed Matter::Materials Science ,Dipole ,law ,Monolayer ,Direct and indirect band gaps ,Janus ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
Based on the first-principles calculations, we studied the intrinsic dipole moment and electronic properties of Janus MXY (M = Mo, W; X ≠ Y = S, Se) monolayers, bilayers and heterostructures with graphene, and the possibility of MXY encapsulating graphene. The results show that Janus MXY monolayer has an intrinsic dipole moment and a direct band gap. However, for MXY bilayers strong interlayer coupling will cause direct to indirect band gap transition, and the existence of the dipole moment leads to a significantly large interlayer band offset, being the driving force for the formation of interlayer excitons. In MXY/graphene heterostructures, changes in the direction of intrinsic dipole moment will cause a change in Schottky barrier height and even the transition between p- and n-type Schottky contacts. Independent of the interface atomic layer of Janus MXY, on one hand, the Dirac cone still exists in graphene, proving that MXY is an ideal coating material. On the other hand, the type-II band alignment will disappear as the intrinsic dipole moment disappears, confirming that the intrinsic dipole moment plays a vital role in the formation of a large band offset. Our results provide guidance for the study of interlayer excitonic states, the experimental construction of atomically thin p-n junctions and the encapsulation of graphene.
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- 2020
27. Image based beef and lamb slice authentication using convolutional neural networks
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Dongwei Liu, Ye Ma, Shiqiang Yu, and Chao Zhang
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Red Meat ,Sheep ,Meat ,Ducks ,Animals ,Cattle ,Neural Networks, Computer ,Food Science - Abstract
Meat adulteration affects customers and the market. Existing meat authentication methods usually rely on special devices, and thus are limited to professional use only. Fake lamb or beef slices made from duck and fat appear in some Chinese hotpot restaurants. This study present a customer-conducted method for detecting such adulteration. The method takes a single image as input, and authenticates it by using the textural features of meat slices. The authentication is rapid and non-destructive. The only device required is a mobile phone with a camera. A lightweight (thus high-efficient) convolutional neural network architecture called MTx-Net was built for this task. Fourteen convolutional layers in four blocks were used for extracting valid visual features. Techniques like residuals, depth-wise convolution, dropout and batch normalization were employed in the neural network. For training and testing the neural network, 77956 meat images were collected using 225Kg of meats. This method achieves 99.38% and 98.20% accuracy on lamb and beef slice authentication, respectively.
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- 2023
28. Nitrogen-incorporation activates NiFeOx catalysts for efficiently boosting oxygen evolution activity and stability of BiVO4 photoanodes
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Lingjun Chou, Xiaojuan Huang, Ying Dai, Gongxuan Lu, Yingpu Bi, Guojun Dong, Shiqiang Yu, and Beibei Zhang
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Photocurrent ,Multidisciplinary ,Science ,Oxygen evolution ,General Physics and Astronomy ,chemistry.chemical_element ,General Chemistry ,Partial substitution ,Nitrogen ,General Biochemistry, Genetics and Molecular Biology ,Catalysis ,chemistry ,Chemical engineering ,Reversible hydrogen electrode ,Water splitting ,Dissolution - Abstract
Developing low-cost and highly efficient catalysts toward the efficient oxygen evolution reaction (OER) is highly desirable for photoelectrochemical (PEC) water splitting. Herein, we demonstrated that N-incorporation could efficiently activate NiFeOx catalysts for significantly enhancing the oxygen evolution activity and stability of BiVO4 photoanodes, and the photocurrent density has been achieved up to 6.4 mA cm−2 at 1.23 V (vs. reversible hydrogen electrode (RHE), AM 1.5 G). Systematic studies indicate that the partial substitution of O sites in NiFeOx catalysts by low electronegative N atoms enriched the electron densities in both Fe and Ni sites. The electron-enriched Ni sites conversely donated electrons to V sites of BiVO4 for restraining V5+ dissolution and improving the PEC stability, while the enhanced hole-attracting ability of Fe sites significantly promotes the oxygen-evolution activity. This work provides a promising strategy for optimizing OER catalysts to construct highly efficient and stable PEC water splitting devices.
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- 2021
29. Promoting Electrocatalytic Reduction of CO
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Yugang, Gao, Shiqiang, Yu, Peng, Zhou, Xixi, Ren, Zeyan, Wang, Zhaoke, Zheng, Peng, Wang, Hefeng, Cheng, Yuanyuan, Liu, Wei, Wei, Ying, Dai, and Baibiao, Huang
- Abstract
The electrochemical CO
- Published
- 2021
30. Robust Intrinsic Multiferroicity in a FeHfSe
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Shiqiang, Yu, Yuanyuan, Wang, Shuhua, Wang, Haona, Zhang, Baibiao, Huang, Ying, Dai, and Wei, Wei
- Abstract
As a consequence of the mutually exclusive origins of ferroelectricity and magnetism, multiferroic materials with electromagnetic coupling are rare. In this work, stable two-dimensional FeHfSe
- Published
- 2021
31. User preference enabled intelligent 3D product evolutionary design
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Shiqiang Yu, Yuliang Zhou, Cheng Yang, and Chunyang Yu
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0209 industrial biotechnology ,021103 operations research ,Product design ,Computer science ,Process (engineering) ,0211 other engineering and technologies ,3d model ,02 engineering and technology ,Industrial and Manufacturing Engineering ,Preference ,020901 industrial engineering & automation ,Control and Systems Engineering ,Human–computer interaction ,Intelligent design ,Product (mathematics) - Abstract
3D modeling has been widely used in product design and is able to demonstrate design schemes intuitively. However, the process of developing a 3D model is complicated and users can hardly g...
- Published
- 2019
32. GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway
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Xiaowu Wang, Linhe Lu, Liqing Jiang, Shiqiang Yu, Erhe Gao, Ming-gao Zhao, Jincheng Liu, and Yanzhen Tan
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0301 basic medicine ,Cardiac function curve ,medicine.medical_specialty ,Ovariectomy ,Myocardial Infarction ,Estrogen receptor ,030226 pharmacology & pharmacy ,General Biochemistry, Genetics and Molecular Biology ,Receptors, G-Protein-Coupled ,Mice ,Phosphatidylinositol 3-Kinases ,03 medical and health sciences ,0302 clinical medicine ,Fibrosis ,Internal medicine ,medicine ,Animals ,Benzodioxoles ,Myocardial infarction ,General Pharmacology, Toxicology and Pharmaceutics ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,Cardioprotection ,business.industry ,Myocardium ,Heart ,General Medicine ,Fibroblasts ,medicine.disease ,Mice, Inbred C57BL ,Disease Models, Animal ,030104 developmental biology ,Endocrinology ,Receptors, Estrogen ,Quinolines ,Ovariectomized rat ,Female ,Myocardial fibrosis ,business ,Proto-Oncogene Proteins c-akt ,Signal Transduction - Abstract
Aims Estrogen plays an important role in cardioprotection. Animal experiments showed that the G-protein coupled estrogen receptor 30 (GPR30) specific agonist G1 could reduce post-ischemic dysfunction and inhibit cardiac fibroblast proliferation. However, the underlying mechanism of action is not clear. The current study tests the hypothesis that GPR30 reduces myocardial infarct area and fibrosis in female ovariectomized (OVX) mice by activating the PI3K/AKT pathway. Main methods In this study, we established a myocardial infarction (MI) animal model derived from OVX C57BL/6 female mice, and investigated the effect of G1 on cardiac function by echocardiography and Hemodynamics, morphology and expression of fibrosis-related and apoptosis-related proteins by Masson's trichrome and H&E, Immunofluorescence, Western blotting and TUNEL. Key findings Combination with OVX significantly increased myocardial fibrosis and MI area compared to MI treatment alone, as determined by echocardiography and hemodynamics. Further addition of G1 changed the expression of apoptosis-related proteins, decreased the levels of tumor necrosis factor-α and interleukin-10, and reduced the degree of myocardial fibrosis and myocardial infarct area. Primary cultured cardiac fibroblasts (CFs) were subjected to hypoxia/serum deprivation (H/SD) simulating the in vivo ischemia model. When the PI3K/AKT pathway was inhibited by wortmanin in H/SD CFs, G1 failed to induce significant changes in the expression of apoptosis-related proteins. Significance It suggested that GPR30 may improve cardiac function in female OVX mice by activating the PI3K/AKT pathway and reducing myocardial infarct size and fibrosis.
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- 2019
33. Myricetin ameliorated ischemia/reperfusion-induced brain endothelial permeability by improvement of eNOS uncoupling and activation eNOS/NO
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Hu Xuehui, Rong Zhao, Shiqiang Yu, Lei Shi, Shun Guo, Song Zhang, He Qing, and Ping Zhang
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0301 basic medicine ,Nitric Oxide Synthase Type III ,NF-E2-Related Factor 2 ,Ischemia ,Inflammation ,Pharmacology ,Nitric Oxide ,Protective Agents ,Flavones ,Permeability ,Brain Ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Enos ,medicine ,Humans ,Protein kinase B ,Cells, Cultured ,PI3K/AKT/mTOR pathway ,Flavonoids ,chemistry.chemical_classification ,biology ,lcsh:RM1-950 ,Brain ,Endothelial Cells ,Enos uncoupling ,medicine.disease ,biology.organism_classification ,Oxidative Stress ,lcsh:Therapeutics. Pharmacology ,Glucose ,030104 developmental biology ,chemistry ,Blood-Brain Barrier ,Reperfusion Injury ,Molecular Medicine ,Myricetin ,medicine.symptom ,030217 neurology & neurosurgery ,Phytotherapy - Abstract
Disruption of the blood–brain barrier (BBB) has been considered as a major pathological change in stroke. eNOS/NO play a key role in maintain BBB function. Myricetin is one of the common flavones widely exists in food and fruit, show certain protective effect on the brain function. This experiment establishes oxygeneglucose deprivation and reoxygenation (OGD/R) brain cell model. The regulated effects of Myricetin on BBB function, eNOS/NO and eNOS uncoupling were evaluated. To investigate the molecular mechanism, Akt and Nrf2 inhibitor were also used. The result showed that Myricetin could significantly decreased the enhancement of endothelial permeability and inflammation in OGD/R model, in addition regulated eNOS/NO pathway. The regulate effect in endothelial permeability and eNOS activity by Myricetin were both decreased when combined with Akt inhibitor or Nrf2 inhibitor, and was abrogated when combined with Akt and Nrf2 inhibitor simultaneously. The regulated effect on eNOS uncoupling by Myricetin were abrogated when combined with Nrf2 inhibitor, but not with Akt inhibitor. In conclusion, Myricetin showed significant protect effect on ischemia/reperfusion-induced brain endothelial permeability, and related to simultaneously regulated Akt pathway and improvement of eNOS uncoupling through Nrf2 pathway. Keywords: Ischemia/reperfusion injury, eNOS/NO, eNOS uncoupling, Myricetin
- Published
- 2019
34. Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling
- Author
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Shiqiang Yu, Jipeng Ma, Linhe Lu, Yang Liu, Jun Ren, Lifang Yang, Lanlan Li, Jian Yang, Hong Guo, Jiayou Tang, and He-Ping Bai
- Subjects
0301 basic medicine ,Apoptosis ,Myocardial Reperfusion Injury ,Pharmacology ,Biochemistry ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Sirtuin 1 ,Downregulation and upregulation ,In vivo ,medicine ,Animals ,Myocytes, Cardiac ,heterocyclic compounds ,Receptor ,Molecular Biology ,Metoprolol ,Cell Biology ,Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ,In vitro ,Rats ,030104 developmental biology ,Terminal deoxynucleotidyl transferase ,chemistry ,030220 oncology & carcinogenesis ,Quercetin ,medicine.drug - Abstract
AIM To evaluate the effects of quercetin to improve ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro and in vivo study. METHODS The cells were divided into five groups: model control (MC) group was ischemia/reperfusion (I/R) model group; DL group was treated with 25 mL/L quercetin based on MC group; DM group was treated with 50 ml/L quercetin based on MC group; DH group was treated with 100 mL/L quercetin based on MC group; Meto group was treated with metoprolol based on MC group. In the in vivo study, the rats were divided into five groups: MC group was I/R model group; DL group was treated with 25 mg/kg quercetin; DM group was treated with 50 mg/kg quercetin; DM group was treated with 100 mg/kg quercetin; Meto group was treated with Meto as positive drug. RESULTS The cell apoptosis rates of quercetin treated groups (DL, DM, and DH groups) were significantly suppressed compared with the MC group. The silent information regulatory factor 1 (SIRT1), peroxisome proliferators-activated receptor-γ coactivator-1α (PGC-1α), and Bcl-2 proteins expression of quercetin treated were significantly upregulation compared with MC group (P
- Published
- 2019
35. A self-expanding percutaneous valve for patients with pulmonary regurgitation and an enlarged native right ventricular outflow tract: one-year results
- Author
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Junbo Ge, Jinfen Liu, Daxin Zhou, Xin Pan, Qiling Cao, Wenzhi Pan, Ge-Jun Zhang, Shiqiang Yu, Hasan Jilaihawi, and Yuan Feng
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Adolescent ,Ventricular Outflow Obstruction ,Regurgitation (circulation) ,030204 cardiovascular system & hematology ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Ventricular outflow tract ,030212 general & internal medicine ,Heart Valve Prosthesis Implantation ,Pulmonary Valve ,business.industry ,medicine.disease ,Pulmonary Valve Insufficiency ,Pulmonary embolism ,Treatment Outcome ,medicine.anatomical_structure ,Pulmonary valve ,Infective endocarditis ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Atrial flutter ,Follow-Up Studies - Abstract
AIMS The aim of the study was to evaluate the midterm safety and efficacy of a self-expanding valve (Venus P-valve) in the treatment of patients with pulmonary regurgitation and a native right ventricular outflow tract (RVOT) in China. METHODS AND RESULTS Patients who had moderate or severe pulmonary regurgitation after surgical repair of the RVOT with a transannular or RVOT patch were included in the study. Fifty-five patients (67% female; average age 28.7±12.4 years) from six different hospitals in China were enrolled. The procedure success rate was 98.2%. In the one failure, the patient experienced valve dislodgement two days after the procedure. During the 12-month follow-up, two patients died, one due to infective endocarditis. Three other patients developed infective endocarditis. Two patients developed atrial flutter, and one patient had a pulmonary embolism. Echocardiography examinations at 12 months showed that two patients had mild pulmonary regurgitation, and 19 patients had trace pulmonary regurgitation. No paravalvular regurgitation occurred. The mean peak pulmonary gradient was 16.3±7.4 (range 4-38) mmHg. Compared with the baseline data, the right ventricular end-diastolic volume index (RVEDVI) was reduced from 137.6±15.8 mL/m2 to 83.9±16.0 mL/m2 (p
- Published
- 2019
36. GDF11 alleviates pathological myocardial remodeling in diabetic cardiomyopathy through SIRT1-dependent regulation of oxidative stress and apoptosis
- Author
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Ye-Nong Zhou, Erhe Gao, Liyun Zhang, Lu Xu, Liqing Jiang, Weixun Duan, Heng Shi, Lin Xia, Dong-Xu Wang, Wei Ding, Jincheng Liu, Shiqiang Yu, Hanzhao Zhu, Xiang Li, Mengen Zhai, Yu Cao, and Kaifeng Li
- Subjects
0301 basic medicine ,growth differentiation factor 11 ,QH301-705.5 ,Inflammation ,030204 cardiovascular system & hematology ,Pharmacology ,medicine.disease_cause ,sirtuin 1 ,03 medical and health sciences ,Cell and Developmental Biology ,0302 clinical medicine ,Diabetic cardiomyopathy ,medicine ,diabetic cardiomyopathy ,oxidative stress ,Biology (General) ,Original Research ,chemistry.chemical_classification ,Reactive oxygen species ,biology ,Sirtuin 1 ,business.industry ,apoptosis ,Cell Biology ,medicine.disease ,030104 developmental biology ,chemistry ,Apoptosis ,biology.protein ,cardiovascular system ,medicine.symptom ,Signal transduction ,business ,Oxidative stress ,Developmental Biology ,Transforming growth factor - Abstract
Background Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte injury, which induced by metabolic disorder. Nowadays, there is still a lack of drugs for the treatment of DCM. Growth differentiation factor 11 (GDF11) is a novel member of the transforming growth factor β superfamily that alleviates cardiac hypertrophy, myocardial infarction, and vascular injury by regulating oxidative stress, inflammation, and cell survival. However, the roles and underlying mechanisms of GDF11 in DCM remain largely unknown. Methods In this study, we sought to determine whether GDF11 could prevent DCM. The mouse model of diabetes was established by administering a high-fat diet and intraperitoneal injecting streptozotocin. After that, intramyocardial injection of an adeno-associated virus carrying GDF11 gene was used to achieve myocardium-specific overexpression. Results Our data showed that GDF11 overexpression remarkably improved cardiac dysfunction and interstitial fibrosis by reducing the levels of reactive oxygen species and protecting against cardiomyocyte loss. Mechanistically, decreased sirtuin 1 (SIRT1) expression was observed in diabetic mice, which was significantly increased after GDF11 overexpression. To further explore how SIRT1 mediates the role of GDF11, the selective inhibitor EX527 was used to block SIRT1 signaling pathway, which abolished the protective effects of GDF11 against DCM. In vitro studies confirmed that GDF11 protected against H9c2 cell injury in high glucose and palmitate by attenuating oxidative injury and apoptosis, and these effects were also eliminated by SIRT1 depletion. Conclusion Our results demonstrated for the first time that GDF11 protected against DCM by regulating SIRT1 signaling pathway, and GDF11 had the potential to become a novel target for reversing cardiac dysfunction in diabetic patients.
- Published
- 2021
37. Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation
- Author
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Hanzhao Zhu, Liyun Zhang, Hao Jia, Lu Xu, Yu Cao, Mengen Zhai, Kaifeng Li, Lin Xia, Liqing Jiang, Xiang Li, Yenong Zhou, Jincheng Liu, Shiqiang Yu, and Weixun Duan
- Subjects
Pharmacology ,Inflammation ,Lipopolysaccharides ,Curcumin ,MAP Kinase Signaling System ,Pharmaceutical Science ,Mice ,Oxidative Stress ,Complementary and alternative medicine ,Sepsis ,Drug Discovery ,Molecular Medicine ,Animals ,Dronabinol ,Cardiomyopathies - Abstract
Acute myocardial dysfunction in patients with sepsis is attributed to oxidative stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are still lacking. Tetrahydrocurcumin (THC) has been proven to contribute to the prevention of various cardiovascular diseases by decreasing oxidative stress and inflammation. This study was performed to investigate the functions and mechanism of action of THC in septic cardiomyopathy.After the oral administration of THC (120 mg/kg) for 5 consecutive days, a mouse model of sepsis was established via intraperitoneal lipopolysaccharide (LPS, 10 mg/kg) injection. Following this, cardiac function was assessed, pathological section staining was performed, and inflammatory markers were detected.Myocardial systolic function was severely compromised in parallel with the accumulation of reactive oxygen species and enhanced cardiomyocyte apoptosis in mice with sepsis. These adverse changes were markedly reversed in response to THC treatment in septic mice as well as in LPS-treated H9c2 cells. Mechanistically, THC inhibited the release of pro-inflammatory cytokines, including tumor necrosis factor alpha, interleukin (IL)-1β, and IL-6, by upregulating mitogen-activated protein kinase phosphatase 1, to block the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase (ERK). Additionally, THC enhanced the levels of antioxidant proteins, including nuclear factor-erythroid 2-related factor 2, superoxide dismutase 2, and NAD(P)H quinone oxidoreductase 1, while decreasing gp91Our findings indicate that THC exhibited protective potential against septic cardiomyopathy by reducing oxidative stress and inflammation through the regulation of JNK/ERK signaling. The findings of this study provide a basis for the further evaluation of THC as a therapeutic agent against septic cardiomyopathy.
- Published
- 2021
38. Nitrogen-incorporation activates NiFeO
- Author
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Beibei, Zhang, Shiqiang, Yu, Ying, Dai, Xiaojuan, Huang, Lingjun, Chou, Gongxuan, Lu, Guojun, Dong, and Yingpu, Bi
- Subjects
Nanoscale materials ,Photochemistry ,Article ,Materials for energy and catalysis - Abstract
Developing low-cost and highly efficient catalysts toward the efficient oxygen evolution reaction (OER) is highly desirable for photoelectrochemical (PEC) water splitting. Herein, we demonstrated that N-incorporation could efficiently activate NiFeOx catalysts for significantly enhancing the oxygen evolution activity and stability of BiVO4 photoanodes, and the photocurrent density has been achieved up to 6.4 mA cm−2 at 1.23 V (vs. reversible hydrogen electrode (RHE), AM 1.5 G). Systematic studies indicate that the partial substitution of O sites in NiFeOx catalysts by low electronegative N atoms enriched the electron densities in both Fe and Ni sites. The electron-enriched Ni sites conversely donated electrons to V sites of BiVO4 for restraining V5+ dissolution and improving the PEC stability, while the enhanced hole-attracting ability of Fe sites significantly promotes the oxygen-evolution activity. This work provides a promising strategy for optimizing OER catalysts to construct highly efficient and stable PEC water splitting devices., While solar-to-fuel conversion offers a renewable energy production strategy, photoelectrochemical water splitting requires further optimization. Here, authors examined nitrogen-doped NiFeOx catalysts to improve the oxygen evolution activity and stability of BiVO4 photoanodes.
- Published
- 2021
39. Hydrogen adsorption behavior on AXenes Na2N and K2N: a first-principles study
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Shuping Dong, Haona Zhang, Shiqiang Yu, Baibiao Huang, Ying Dai, and Wei Wei
- Subjects
Biomaterials ,Polymers and Plastics ,Metals and Alloys ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
It is a consensus that the hydrogen economy has come to a standstill due to the lack of feasible hydrogen storage solutions, especially, the suitable hydrogen storage materials. In this work, the potential of a new kind of two-dimensional (2D) AXenes, Na2N and K2N, as hydrogen storage materials are evaluated by the first-principles calculations. In particular, we find that Na2N in T phase indicates a hydrogen storage capacity as high as 6.25 wt% with a desirable hydrogen adsorption energy of –0.167 eV per H2 molecule and a desorption temperature of 216 K, identifying T-phase Na2N to be a very promising reversible hydrogen storage material. In accordance to our results, H2–Na2N interaction causes H2 charge polarization, which is responsible for the moderate binding strength. In addition, Gibbs adsorption free energy reveals that the system will be more stable as more H2 molecules are loaded on the surface.
- Published
- 2022
40. Clinical Applications of Cardiovascular 3D Printing
- Author
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Alex Pui-Wai Lee, Haibo Zhang, Shiqiang Yu, and Wenzhi Pan
- Subjects
Visual inspection ,Engineering ,business.industry ,Manufacturing ,Human anatomy ,3D printing ,Medical research ,business ,Imaging data ,Surgical planning ,Manufacturing engineering ,3d printer - Abstract
Using imaging data of human anatomy, 3D printing technology can be used for computer reconstruction. The data are the input for a 3D printer, and a structural model is constructed, which is convenient for direct visual inspection and operation [1]. Through more than twenty years of development, outstanding progress has been made in oral, maxillofacial, orthopedic, and plastic surgery and other disciplines. Moreover, 3D printing technology has been widely used in implant and tissue design, surgical planning, medical research, and medical education and as a training tool [2, 3]. Because it has broad development prospects, 3D printing has become an important new technology in the manufacturing industry of “Strategic Emerging Industries Classification (2018)” issued by the National Bureau of Statistics.
- Published
- 2020
41. Novel PGC-1
- Author
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Bing, Zhang, Yanzhen, Tan, Zhengbin, Zhang, Pan, Feng, Wenyuan, Ding, Qian, Wang, Hongliang, Liang, Weixun, Duan, Xiaowu, Wang, Shiqiang, Yu, Jincheng, Liu, Dinghua, Yi, Yang, Sun, and Wei, Yi
- Subjects
Male ,Curcumin ,Myocardium ,Cardiomegaly ,In Vitro Techniques ,Fibrosis ,Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ,Activating Transcription Factors ,Antioxidants ,Rats ,Mice, Inbred C57BL ,Rats, Sprague-Dawley ,Mice ,Oxidative Stress ,Phenylephrine ,Animals, Newborn ,Echocardiography ,Unfolded Protein Response ,Animals ,Myocytes, Cardiac ,RNA, Small Interfering ,Reactive Oxygen Species ,Aorta ,Research Article - Abstract
Mitochondrial unfolding protein response (UPRmt) effectively resists the pathological cardiac hypertrophy and improves the mitochondrial function. However, the specific activation mechanism and drugs that can effectively activate UPRmt in the cardiac muscle are yet to be elucidated. The aim of this study was to determine the regulation role of UPRmt on preventing pathological cardiac hypertrophy by tetrahydrocurcumin (THC) and explore its underlying molecular mechanism. Male C57BL/6J wild-type (WT) mice were divided into a control group and subjected to sham treatment for 4 weeks, and a test group which was subjected to transverse aortic constriction (TAC) surgery. Animals in the control and test group were orally administered THC (50 mg/kg) for 4 weeks after TAC procedure; an equivalent amount of saline was orally administered in the control sham-treated group and the TAC group. Subsequently, oxidative stress and UPRmt markers were assessed in these mice, and cardiac hypertrophy, fibrosis, and cardiac function were tested. Small interfering RNA (siRNA) targeting proliferator-activated receptor-gamma coactivator (PGC)-1α and activating transcription factor 5 (ATF5) were used to determine the UPRmt activation mechanism. THC supplement partly upregulated UPRmt effectors and inhibited TAC-induced oxidative stress compared with TAC-operated WT mice, thereby substantially attenuating contractile dysfunction, cardiac hypertrophy, and fibrosis. Furthermore, PGC-1α knockdown blunted the UPRmt activation and the cardioprotective role of THC. The interaction between PGC-1α and ATF5 was tested in neonatal rat cardiac myocytes under normal conditions. The results showed that PGC-1α was an upstream effector of ATF5 and partly activated UPRmt. In vitro, phenylephrine- (PE-) induced cardiomyocyte hypertrophy caused ATF5 upregulating rather than downregulating corresponding to the downregulation of PGC-1α. The PGC-1α/ATF5 axis mediated the UPRmt activation and stress-resistance role of THC in vitro. Collectively, the present study provides the first evidence that PGC-1 and ATF5 can form a signaling axis to partly activate UPRmt that mediates the cardioprotective role of THC in pathological cardiac hypertrophy.
- Published
- 2020
42. Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss
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Zhenxiao Jin, Peng Hou, Jincheng Liu, Zhenhua Liu, Jian Yang, Mengen Zhai, Liyun Zhang, Weixun Duan, Hanzhao Zhu, Junfeng Li, Dinghua Yi, Chang Sun, Lin Xia, Shiqiang Yu, Xiaowu Wang, Hongliang Liang, Wei Yi, Kaifeng Li, Liqing Jiang, and Buying Li
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Vascular smooth muscle ,Myocytes, Smooth Muscle ,Cell ,Matrix metalloproteinase ,medicine.disease_cause ,Thoracic aortic aneurysm ,Melatonin receptor ,Muscle, Smooth, Vascular ,Melatonin ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Sirtuin 1 ,Internal medicine ,medicine ,Animals ,Aortic Aneurysm, Thoracic ,biology ,business.industry ,medicine.disease ,Aortic Dissection ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,cardiovascular system ,biology.protein ,business ,hormones, hormone substitutes, and hormone antagonists ,030217 neurology & neurosurgery ,Oxidative stress ,medicine.drug - Abstract
Melatonin functions as an endogenous protective molecule in multiple vascular diseases, whereas its effects on thoracic aortic aneurysm and dissection (TAAD) and underlying mechanisms have not been reported. In this study, TAAD mouse model was successfully induced by β-aminopropionitrile fumarate (BAPN). We found that melatonin treatment remarkably prevented the deterioration of TAAD, evidenced by decreased incidence, ameliorated aneurysmal dilation and vascular stiffness, improved aortic morphology, and inhibited elastin degradation, macrophage infiltration, and matrix metalloproteinase expression. Moreover, melatonin blunted oxidative stress damage and vascular smooth muscle cell (VSMC) loss. Notably, BAPN induced a decrease in SIRT1 expression and activity of mouse aorta, whereas melatonin treatment reversed it. Further mechanistic study demonstrated that blocking SIRT1 signaling partially inhibited these beneficial effects of melatonin on TAAD. Additionally, the melatonin receptor was involved in this phenomenon. Our study is the first to report that melatonin exerts therapeutic effects against TAAD by reducing oxidative stress and VSMC loss via activation of SIRT1 signaling in a receptor-dependent manner, thus suggesting a novel therapeutic strategy for TAAD.
- Published
- 2020
43. Modified Glucose‐Insulin‐Potassium Regimen Provides Cardioprotection With Improved Tissue Perfusion in Patients Undergoing Cardiopulmonary Bypass Surgery
- Author
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Yue Zhang, Rong Zhao, Xin-Liang Ma, Qin Cui, Kun Zhao, Yi Wan, Bijun Zhao, Jincheng Liu, Wensheng Chen, Shiqiang Yu, Dinghua Yi, Jia Li, and Feng Gao
- Subjects
insulin ,medicine.medical_specialty ,Acute coronary syndrome ,medicine.medical_treatment ,Insulins ,030204 cardiovascular system & hematology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Cardiopulmonary bypass ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Original Research ,Cardioprotection ,Cardiovascular Surgery ,Cardiopulmonary Bypass ,business.industry ,Insulin ,tissue perfusion ,medicine.disease ,Cardiac surgery ,Regimen ,Glucose ,Potassium ,Cardiology ,Sugars ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,cardiac surgery - Abstract
Background Laboratory studies demonstrate glucose‐insulin‐potassium ( GIK ) as a potent cardioprotective intervention, but clinical trials have yielded mixed results, likely because of varying formulas and timing of GIK treatment and different clinical settings. This study sought to evaluate the effects of modified GIK regimen given perioperatively with an insulin‐glucose ratio of 1:3 in patients undergoing cardiopulmonary bypass surgery. Methods and Results In this prospective, randomized, double‐blinded trial with 930 patients referred for cardiac surgery with cardiopulmonary bypass , GIK (200 g/L glucose, 66.7 U/L insulin, and 80 mmol/L KC l) or placebo treatment was administered intravenously at 1 mL /kg per hour 10 minutes before anesthesia and continuously for 12.5 hours. The primary outcome was the incidence of in‐hospital major adverse cardiac events including all‐cause death, low cardiac output syndrome, acute myocardial infarction, cardiac arrest with successful resuscitation, congestive heart failure, and arrhythmia. GIK therapy reduced the incidence of major adverse cardiac events and enhanced cardiac function recovery without increasing perioperative blood glucose compared with the control group. Mechanistically, this treatment resulted in increased glucose uptake and less lactate excretion calculated by the differences between arterial and coronary sinus, and increased phosphorylation of insulin receptor substrate‐1 and protein kinase B in the hearts of GIK ‐treated patients. Systemic blood lactate was also reduced in GIK ‐treated patients during cardiopulmonary bypass surgery. Conclusions A modified GIK regimen administered perioperatively reduces the incidence of in‐hospital major adverse cardiac events in patients undergoing cardiopulmonary bypass surgery. These benefits are likely a result of enhanced systemic tissue perfusion and improved myocardial metabolism via activation of insulin signaling by GIK . Clinical Trial Registration URL: clinicaltrials.gov. Identifier: NCT 01516138.
- Published
- 2020
44. Total arch repair with open placement of a novel double-branched stent graft for acute Type A aortic dissection: a single-centre experience with 21 consecutive patients
- Author
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Weixun Duan, Shiqiang Yu, Zhenxiao Jin, Jian Yang, Bo Yu, Jincheng Liu, Zhenhua Liu, and Chao Xue
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,Aortic arch ,medicine.medical_specialty ,Computed Tomography Angiography ,medicine.medical_treatment ,Subclavian Artery ,030204 cardiovascular system & hematology ,Prosthesis Design ,Cohort Studies ,Blood Vessel Prosthesis Implantation ,03 medical and health sciences ,Aortic aneurysm ,0302 clinical medicine ,Aneurysm ,Blood vessel prosthesis ,medicine.artery ,medicine ,Humans ,Hospital Mortality ,Subclavian artery ,Retrospective Studies ,Aortic dissection ,Aortic Aneurysm, Thoracic ,business.industry ,Stent ,Middle Aged ,medicine.disease ,Blood Vessel Prosthesis ,Surgery ,Aortic Dissection ,Treatment Outcome ,030228 respiratory system ,Descending aorta ,Female ,Stents ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives The aim of this study was to evaluate the safety and feasibility of total arch repair with open placement of a novel double-branched stent graft for acute Type A aortic dissection (TAAD). Methods We retrospectively analysed the effect of the double-branched stent graft for total aortic arch placement with acute TAAD from December 2013 to February 2015. The effectiveness of the open placement of the double-branched stent graft was estimated by complete thrombus obliteration of the false lumen surrounding it on computed tomography angiography. Follow-up was performed at 6 months postoperatively and annually thereafter. Results The double-branched stent graft was successfully placed into the true lumen of the descending aorta, aortic arch, left subclavian artery and left common carotid artery through the delivery system in 21 patients with acute TAAD. The mean cardiopulmonary bypass time was 210.2 ± 32.4 min, the mean aortic cross-clamp time was 94.9 ± 18.0 min, and the selective cerebral perfusion and deep hypothermia cardiopulmonary arrest time was 27.0 ± 10.4 min. The in-hospital mortality rate was 4.8%. The mean follow-up duration was 38.2 ± 12.5 months. No severe complications related to the surgery or residual dissection occurred during the follow-up. All survivors resumed normal activities. Conclusions The novel double-branched stent graft is proved to be safe and effective for total arch repair with acute TAAD in this study. It would be a new selective method for total arch repair in patients with acute TAAD. Clinical registration number Research on pathogenic risk factors or characteristic features and clinical treatment of aortic dissection in Chinese Population (20120216-4).
- Published
- 2018
45. Smart manufacturing systems for Industry 4.0: Conceptual framework, scenarios, and future perspectives
- Author
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Runyang Zhong, Chao Liu, Khamdi Mubarok, Yongkui Liu, Shiqiang Yu, Pai Zheng, Honghui wang, Zhiqian Sang, and Xun Xu
- Subjects
0209 industrial biotechnology ,Industry 4.0 ,business.industry ,Computer science ,Mechanical Engineering ,Big data ,Cyber-physical system ,Cloud computing ,02 engineering and technology ,Metaverse ,020901 industrial engineering & automation ,Conceptual framework ,Information and Communications Technology ,Manufacturing ,0202 electrical engineering, electronic engineering, information engineering ,Systems engineering ,020201 artificial intelligence & image processing ,business - Abstract
Information and communication technology is undergoing rapid development, and many disruptive technologies, such as cloud computing, Internet of Things, big data, and artificial intelligence, have emerged. These technologies are permeating the manufacturing industry and enable the fusion of physical and virtual worlds through cyber-physical systems (CPS), which mark the advent of the fourth stage of industrial production (i.e., Industry 4.0). The widespread application of CPS in manufacturing environments renders manufacturing systems increasingly smart. To advance research on the implementation of Industry 4.0, this study examines smart manufacturing systems for Industry 4.0. First, a conceptual framework of smart manufacturing systems for Industry 4.0 is presented. Second, demonstrative scenarios that pertain to smart design, smart machining, smart control, smart monitoring, and smart scheduling, are presented. Key technologies and their possible applications to Industry 4.0 smart manufacturing systems are reviewed based on these demonstrative scenarios. Finally, challenges and future perspectives are identified and discussed.
- Published
- 2018
46. Promoting Electrocatalytic Reduction of CO 2 to C 2 H 4 Production by Inhibiting C 2 H 5 OH Desorption from Cu 2 O/C Composite
- Author
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Yugang Gao, Shiqiang Yu, Peng Zhou, Xixi Ren, Zeyan Wang, Zhaoke Zheng, Peng Wang, Hefeng Cheng, Yuanyuan Liu, Wei Wei, Ying Dai, and Baibiao Huang
- Subjects
Biomaterials ,General Materials Science ,General Chemistry ,Biotechnology - Published
- 2021
47. Percutaneous trans-apex intra-septal radiofrequency ablation of hypertrophic cardiomyopathy
- Author
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Shiqiang Yu, Lize Xiong, Bing Liu, Mengyao Zhou, Jian Yang, Chao Sun, Junbo Ge, Lei Zuo, Ruiqi Guo, and Liwen Liu
- Subjects
medicine.medical_specialty ,Percutaneous ,Radiofrequency ablation ,Peak pressure ,030204 cardiovascular system & hematology ,Obstructive cardiomyopathy ,law.invention ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,law ,Internal medicine ,Heart Septum ,medicine ,Humans ,Ventricular outflow tract ,Interventricular septum ,Aged ,business.industry ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Apex (geometry) ,medicine.anatomical_structure ,Catheter Ablation ,cardiovascular system ,Cardiology ,Female ,Surgery ,business - Abstract
A 70-year-old woman presented with severe hypertrophic obstructive cardiomyopathy (HOCM) (maximum ventricular septum thickness of 28 mm, peak pressure gradient (PG) in the left ventricular outflow tract (LVOT) of 153 mmHg). We performed percutaneous trans-apex intra-septal radiofrequency ablation (PTAISRA) of the interventricular septum under guidance of transthoracic echocardiography. At six-months follow up, the symptoms were significantly relieved; the septal thickness was reduced to 18 mm and the peak LVOT PG reduced to 44 mmHg. This case highlights a novel use of radiofrequency ablation for the treatment of HOCM. Long-term safety and efficacy merit evaluation.
- Published
- 2017
48. VarCatcher: A Framework for Tackling Performance Variability of Parallel Workloads on Multi-Core
- Author
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Haibo Chen, Shiqiang Yu, Tao Li, Xiaofeng Ji, Bo Song, Weihua Zhang, Wenyun Zhao, and Pen-Chung Yew
- Subjects
010302 applied physics ,Multi-core processor ,Computer science ,Design space exploration ,Distributed computing ,02 engineering and technology ,01 natural sciences ,020202 computer hardware & architecture ,Visualization ,Computational Theory and Mathematics ,Hardware and Architecture ,0103 physical sciences ,Signal Processing ,0202 electrical engineering, electronic engineering, information engineering ,Feature (machine learning) ,Statistical inference ,Cluster analysis ,TRACE (psycholinguistics) - Abstract
The non-deterministic nature of multi-threaded workloads running on multi-core platforms often leads to notable performance variability from run to run. Such variability makes experimental results prone to misinterpretations or misguided claims. To deal with such variability, statistical inference methods are usually used to summarize the experimental results with certain confidence levels by running the experiments or measurements a large number of times. However, such statistical results are often too vague or too simplistic. They are not sufficient to help users understand the causes of such variability, and allow more in-depth analysis on the results or reproduce the results for validation during design space exploration. To allow better analyzability and reproducibility, we propose a framework to tackle such variability, called VarCatcher. The key to VarCatcher is to characterize a parallel execution using Parallel Characteristics Vector (PCV). A clustering-based approach is then used to group runs with similar execution characteristics that can later be used to analyze results in-depth, to customize different evaluation strategies, reproduce the result for variability, to determine the impact of features, or to assist performance diagnosis. We have built a prototype of VarCatcher that includes a user-level toolset for runtime monitoring and measurements using the Intel Processor Trace feature on commodity Intel processors as well as an architecture extension with very low runtime overheads (around 3 and 0.01 percent accordingly). Several case studies confirm that VarCatcher enables several appealing features such as in-depth result analysis, customized evaluation strategies, and reproducibility.
- Published
- 2017
49. Personalized product configuration framework in an adaptable open architecture product platform
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Xun Xu, Shiqiang Yu, Pai Zheng, and Chao Liu
- Subjects
Product design specification ,0209 industrial biotechnology ,Engineering ,Product design ,business.industry ,05 social sciences ,02 engineering and technology ,Product engineering ,Industrial and Manufacturing Engineering ,Configurator ,020901 industrial engineering & automation ,Product lifecycle ,Hardware and Architecture ,Control and Systems Engineering ,0502 economics and business ,New product development ,Systems engineering ,Product management ,Product (category theory) ,Software engineering ,business ,050203 business & management ,Software - Abstract
Product configuration system, as an effective tool to bridge the gap between customer requirements and product offerings, enables customer-centric product development in a cost-efficient way. Despite its advantages, however, most existing product configurators are centralized, i.e. the configuration process is conducted in a single company within its own product family. It cannot fulfill the ever increasing tendency towards personalization. This is because customers no longer have to choose from the limited options within the company’s solution space in a “configure-to-order” (CTO) model, they also propose or even create their individualized design in an “engineer-to-order” (ETO) model. Moreover, companies, especially large ones, are not willing to invest much into the niche market to produce the highly personalized components. To solve this problem, an open architecture product platform with adaptable interface can be adopted to integrate the original equipment manufacturer (OEM) with various vendors into a co-creation process. This paper proposes a conceptual framework of a personalized product configuration system based on the adaptable open architecture product platform. The technical configurator is enabled by a two-stage process (i.e. modular design and scalable design) to ensure the adaptability and scalability of product variety, while the sales configurator is established by considering each customer’s preferences and conducting the configuration process in an ETO manner. The technical details of the prototype system implementation are described and an illustrative example of a personalized bicycle configuration process is given to validate the overall framework.
- Published
- 2017
50. User-experience Based Product Development for Mass Personalization: A Case Study
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Shiqiang Yu, Ray Y. Zhong, Xun Xu, Yuanbin Wang, and Pai Zheng
- Subjects
0209 industrial biotechnology ,Engineering ,Knowledge management ,business.industry ,Information technology ,Wearable computer ,Cloud computing ,02 engineering and technology ,Product engineering ,Personalization ,020901 industrial engineering & automation ,User experience design ,Human–computer interaction ,New product development ,0202 electrical engineering, electronic engineering, information engineering ,General Earth and Planetary Sciences ,020201 artificial intelligence & image processing ,Product (category theory) ,business ,General Environmental Science - Abstract
Nowadays, with the rapid development of information technologies (e.g. web 2.0, cloud computing and virtual reality) and manufacturing technologies (e.g. additive manufacturing), users become more actively involved in the product development stage to create personalized products with higher efficiency. This emerging manufacturing paradigm is known as mass personalization, of which user experience (e.g. emotional factors and product utility), co-creation (e.g. user participation), and product change (e.g. modular design) are regarded as three key characteristics. In previous studies, researchers often treat each characteristic separately with an illustrative example to demonstrate its significant effect respectively. They, however, cannot fully reflect the product development process for mass personalization, and may cause inconsistency in implementing the existing methods into real cases. To fill the gap, this work proposes a three-model based (i.e. physical model, cyber model and user experience model) generic framework for conducting user experience based product development for mass personalization. A case study of a personalized smart wearable product development is described, of which the three key characteristics are considered collectively. It can also be seen as a typical case integrating the frontier techniques to enable mass personalization. The authors hope this work can provide some useful guidance to product designers and engineer-to-order companies.
- Published
- 2017
Catalog
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