1. Sequential Drug Delivery By Injectable Macroporous Hydrogels For Combined Photodynamic-Chemotherapy
- Author
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Ma Yunsu, Zhenghao Zhou, Shian Sun, Li Zhang, Yuanyuan Zhong, Hao Hong, and Dongzhi Yang
- Subjects
Drug ,Cell Survival ,media_common.quotation_subject ,medicine.medical_treatment ,Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,Bioengineering ,Photodynamic therapy ,Antineoplastic Agents ,Pharmacology ,Applied Microbiology and Biotechnology ,Theranostic Nanomedicine ,chemistry.chemical_compound ,Mice ,Drug Delivery Systems ,In vivo ,Cell Line, Tumor ,Stilbenes ,medicine ,polycyclic compounds ,Medical technology ,Sequential drug delivery ,Animals ,Doxorubicin ,R855-855.5 ,media_common ,Mice, Inbred BALB C ,Chemistry ,Research ,technology, industry, and agriculture ,Hydrogels ,Neoplasms, Experimental ,Mesoporous silica ,Porphyrin ,Combined photodynamic-chemotherapy ,Photochemotherapy ,Drug delivery ,Self-healing hydrogels ,Molecular Medicine ,Nanoparticles ,Female ,TP248.13-248.65 ,medicine.drug ,Biotechnology ,Combretastatin A4 phosphate - Abstract
With hollow mesoporous silica (hMSN) and injectable macroporous hydrogel (Gel) used as the internal and external drug-loading material respectively, a sequential drug delivery system DOX-CA4P@Gel was constructed, in which combretastatin A4 phosphate (CA4P) and doxorubicin (DOX) were both loaded. The anti-angiogenic drug, CA4P was initially released due to the degradation of Gel, followed by the anti-cell proliferative drug, DOX, released from hMSN in tumor microenvironment. Results showed that CA4P was mainly released at the early stage. At 48 h, CA4P release reached 71.08%, while DOX was only 14.39%. At 144 h, CA4P was 78.20%, while DOX release significantly increased to 61.60%, showing an obvious sequential release behavior. Photodynamic properties of porphyrin endow hydrogel (φΔ(Gel)=0.91) with enhanced tumor therapy effect. In vitro and in vivo experiments showed that dual drugs treated groups have better tumor inhibition than solo drug under near infrared laser irradiation, indicating the effectivity of combined photodynamic-chemotherapy.
- Published
- 2021