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2. International AIDS Society global scientific strategy: towards an HIV cure 2016

Author

Deeks, Sg, Lewin, Sr, Ross, Al, Ananworanich, J, Benkirane, M, Cannon, P, Chomont, N, Douek, D, Lifson, Jd, Lo, Yr, Kuritzkes, D, Margolis, D, Mellors, J, Persaud, D, Tucker, Jd, Barre-Sinoussi, F, International Aids Society Towards a Cure Working Group, International Aids Society Towards a Cure Working Group, Alter, G, Auerbach, J, Autran, B, Barouch, Dh, Behrens, G, Cavazzana, M, Chen, Z, Cohen, Ea, Corbelli, Gm, Eholié, S, Eyal, N, Fidier, S, Garcia, L, Grossman, C, Henderson, G, Henrich, Tj, Jefferys, R, Kiem, Hp, Mccune, J, Moodley, K, Newman, Pa, Nijhuis, M, Nsubuga, Ms, Ott, M, Palmer, S, Richman, D, Saez-Cirion, A, Sharp, M, Siliciano, J, Silvestri, G, Singh, J, Spire, B, Taylor, J, Tolstrup, M, Valente, S, van Lunzen, J, Walensky, R, Wilson, I, Zack, J, Department of Medicine [San Francisco], University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia, International and Scientific Relations Office, ANRS, Paris, France, Walter Reed Army Institute of Research, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of Southern California (USC), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), National Institutes of Health [Bethesda] (NIH), Frederick National Laboratory for Cancer Research (FNLCR), World Health Organization Regional Office for the Western Pacific, Manila, Philippines, Brigham and Women's Hospital [Boston], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Institut Pasteur [Paris] (IP), Ragon Institute of MGH, MIT and Harvard, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Beth Israel Deaconess Medical Center [Boston] (BIDMC), Harvard Medical School [Boston] (HMS), Clinic for Immunology and Rhematology, Hannover Medical School, Hanover, Germany, Département de Biothérapie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AIDS Institute, The University of Hong Kong, Pok Fu Lam, Hong Kong, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), European AIDS Treatment Group, Italy, Programme PAC-CI, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d'Ivoire, Harvard School of Public Health, Imperial College London, The B-Change Group, Manila, Philippines, Treatment Action Group (TAG), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Stellenbosch University, Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada, University Medical Center [Utrecht], Joint Clinical Research Centre, University of California (UC), The Westmead Institute for Medical Research, University of California [San Diego] (UC San Diego), Independent HIV Education and Advocacy Consultant, San Francisco, California, USA, Emory University [Atlanta, GA], Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CARE Collaboratory Community Advisory Board, Palm Springs, California, USA., Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark., The Scripps Research Institute [La Jolla, San Diego], ViiV Healthcare, London, United Kingdom., Massachusetts General Hospital [Boston], Brown University School of Public Health, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California [San Francisco] (UCSF), University of California-University of California, Institut Pasteur [Paris], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), Department of Medicine, Imperial College London, London, United Kingdom, University of California, Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Scripps Research Institute, Imperial College Healthcare NHS Trust- BRC Funding, American Foundation for AIDS Research, Medical Research Council (MRC), MRC DCS, British HIV Association (BHIVA), and Larose, Catherine

Subjects
CD4(+) T-CELLS, 0301 basic medicine, International Cooperation, [SDV]Life Sciences [q-bio], VIRAL RESERVOIR, Human immunodeficiency virus (HIV), Stakeholder engagement, HIV Infections, [SDV.GEN] Life Sciences [q-bio]/Genetics, Research & Experimental Medicine, medicine.disease_cause, Medicine, Societies, Medical, IN-VIVO, ComputingMilieux_MISCELLANEOUS, HIGHLY PATHOGENIC SIV, virus diseases, LATENT HIV-1, 11 Medical And Health Sciences, General Medicine, TREATMENT INTERRUPTION, 3. Good health, [SDV] Life Sciences [q-bio], International AIDS Society Towards a Cure Working Group, Medicine, Research & Experimental, Goals, Life Sciences & Biomedicine, BROADLY NEUTRALIZING ANTIBODIES, Biochemistry & Molecular Biology, medicine.medical_specialty, RALTEGRAVIR INTENSIFICATION, Immunology, education, Article, General Biochemistry, Genetics and Molecular Biology, HISTONE DEACETYLASE INHIBITOR, 03 medical and health sciences, Global population, Acquired immunodeficiency syndrome (AIDS), SUPPRESSIVE ANTIRETROVIRAL THERAPY, Journal Article, Humans, Organizational Objectives, Acquired Immunodeficiency Syndrome, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, business.industry, Research, Cell Biology, medicine.disease, Antiretroviral therapy, 030104 developmental biology, Treatment interruption, Family medicine, business
Abstract

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy.

Published
2016

3. State of the climate in 2016

Author

Aaron-Morrison, A. P., Ackerman, S. A., Adams, N. G., Adler, R. F., Albanil, A., Alfaro, E. J., Allan, R., Alves, L. M., Amador, J. A., Andreassen, L. M., Arendt, A., Arévalo, J., Arndt, D. S., Arzhanova, N. M., Aschan, M. M., Azorin-Molina, C., Banzon, V., Bardin, M. U., Barichivich, J., Baringer, M. O., Barreira, S., Baxter, S., Bazo, J., Becker, A., Bedka, K. M., Behrenfeld, M. J., Bell, G. D., Belmont, M., Benedetti, A., Bernhard, G., Berrisford, P., Berry, D. I., Bettolli, M. L., Bhatt, U. S., Bidegain, M., Bill, B. D., Billheimer, S., Bissolli, P., Blake, E. S., Blunden, J., Bosilovich, M. G., Boucher, O., Boudet, D., Box, J. E., Boyer, T., Braathen, G. O., Bromwich, D. H., Brown, R., Bulygina, O. N., Burgess, D., Calderón, B., Camargo, S. J., Campbell, J. D., Cappelen, J., Carrasco, G., Carter, B. R., Chambers, D. P., Chandler, E., Christiansen, H. H., Christy, J. R., Chung, D., Chung, E. S., Cinque, K., Clem, K. R., Coelho, C. A., Cogley, J. G., Coldewey-Egbers, M., Colwell, S., Cooper, O. R., Copland, L., Cosca, C. E., Cross, J. N., Crotwell, M. J., Crouch, J., Davis, S. M., Eyto, E., Jeu, R. A. M., Laat, J., Degasperi, C. L., Degenstein, D., Demircan, M., Derksen, C., Destin, D., Di Girolamo, L., Di Giuseppe, F., Diamond, H. J., Dlugokencky, E. J., Dohan, K., Dokulil, M. T., Dolgov, A. V., Dolman, A. J., Domingues, C. M., Donat, M. G., Dong, S., Dorigo, W. A., Dortch, Q., Doucette, G., Drozdov, D. S., Ducklow, H., Dunn, R. J. H., Durán-Quesada, A. M., Dutton, G. S., Ebrahim, A., Elkharrim, M., Elkins, J. W., Espinoza, J. C., Etienne-Leblanc, S., Evans, T. E., Famiglietti, J. S., Farrell, S., Fateh, S., Fausto, R. S., Fedaeff, N., Feely, R. A., Feng, Z., Fenimore, C., Fettweis, X., Fioletov, V. E., Flemming, J., Fogarty, C. T., Fogt, R. L., Folland, C., Fonseca, C., Fossheim, M., Foster, M. J., Fountain, A., Francis, S. D., Franz, B. A., Frey, R. A., Frith, S. M., Froidevaux, L., Ganter, C., Garzoli, S., Gerland, S., Gobron, N., Goldenberg, S. B., Gomez, R. S., Goni, G., Goto, A., Grooß, J. U., Gruber, A., Guard, C. C., Gugliemin, M., Gupta, S. K., Gutiérrez, J. M., Hagos, S., Hahn, S., Haimberger, L., Hakkarainen, J., Hall, B. D., Halpert, M. S., Hamlington, B. D., Hanna, E., Hansen, K., Hanssen-Bauer, I., Harris, I., Heidinger, A. K., Heikkilä, A., Heil, A., Heim, R. R., Hendricks, S., Hernández, M., Hidalgo, H. G., Hilburn, K., Ho, S. P. B., Holmes, R. M., Hu, Z. Z., Huang, B., Huelsing, H. K., Huffman, G. J., Hughes, C., Hurst, D. F., Ialongo, I., Ijampy, J. A., Ingvaldsen, R. B., Inness, A., Isaksen, K., Ishii, M., Jevrejeva, S., Jiménez, C., Jin, X., Johannesen, E., John, V., Johnsen, B., Johnson, B., Johnson, G. C., Jones, P. D., Joseph, A. C., Jumaux, G., Kabidi, K., Kaiser, J. W., Kato, S., Kazemi, A., Keller, L. M., Kendon, M., Kennedy, J., Kerr, K., Kholodov, A. L., Khoshkam, M., Killick, R., Kim, H., Kim, S. J., Kimberlain, T. B., Klotzbach, P. J., Knaff, J. A., Kobayashi, S., Kohler, J., Korhonen, J., Korshunova, N. N., Kovacs, K. M., Kramarova, N., Kratz, D. P., Kruger, A., Kruk, M. C., Kudela, R., Kumar, A., Lakatos, M., Lakkala, K., Lander, M. A., Landsea, C. W., Lankhorst, M., Lantz, K., Lazzara, M. A., Lemons, P., Leuliette, E., L’heureux, M., Lieser, J. L., Lin, I. I., Liu, H., Liu, Y., Locarnini, R., Loeb, N. G., Lo Monaco, C., Long, C. S., López Álvarez, L. A., Lorrey, A. M., Loyola, D., Lumpkin, R., Luo, J. J., Luojus, K., Lydersen, C., Lyman, J. M., Maberly, S. C., Maddux, B. C., Malheiros Ramos, A., Malkova, G. V., Manney, G., Marcellin, V., Marchenko, S. S., Marengo, J. A., Marra, J. J., Marszelewski, W., Martens, B., Martínez-Güingla, R., Massom, R. A., Mata, M. M., Mathis, J. T., May, L., Mayer, M., Mazloff, M., Mcbride, C., Mccabe, M. F., Mccarthy, M., Mcclelland, J. W., Mcgree, S., Mcvicar, T. R., Mears, C. A., Meier, W., Meinen, C. S., Mekonnen, A., Menéndez, M., Mengistu Tsidu, G., Menzel, W. P., Merchant, C. J., Meredith, M. P., Merrifield, M. A., Metzl, N., Minnis, P., Miralles, D. G., Mistelbauer, T., Mitchum, G. T., Monselesan, D., Monteiro, P., Montzka, S. A., Morice, C., Mote, T., Mudryk, L., Mühle, J., Mullan, A. B., Nash, E. R., Naveira-Garabato, A. C., Nerem, R. S., Newman, P. A., Nieto, J. J., Noetzli, J., O’neel, S., Osborn, T. J., Overland, J., Oyunjargal, L., Parinussa, R. M., Park, E. H., Parker, D., Parrington, M., Parsons, A. R., Pasch, R. J., Pascual-Ramírez, R., Paterson, A. M., Paulik, C., Pearce, P. R., Pelto, M. S., Peng, L., Perkins-Kirkpatrick, S. E., Perovich, D., Petropavlovskikh, I., Pezza, A. B., Phillips, D., Pinty, B., Pitts, M. C., Pons, M. R., Porter, A. O., Primicerio, R., Proshutinsky, A., Quegan, S., Quintana, J., Rahimzadeh, F., Rajeevan, M., Randriamarolaza, L., Razuvaev, V. N., Reagan, J., Reid, P., Reimer, C., Rémy, S., Renwick, J. A., Revadekar, J. V., Richter-Menge, J., Riffler, M., Rimmer, A., Rintoul, S., Robinson, D. A., Rodell, M., Rodríguez Solís, J. L., Romanovsky, V. E., Ronchail, J., Rosenlof, K. H., Roth, C., Rusak, J. A., Sabine, C. L., Sallée, J. B., Sánchez-Lugo, A., Santee, M. L., Sawaengphokhai, P., Sayouri, A., Scambos, T. A., Schemm, J., Schladow, S. G., Schmid, C., Schmid, M., Schmidtko, S., Schreck, C. J., Selkirk, H. B., Send, U., Sensoy, S., Setzer, A., Sharp, M., Shaw, A., Shi, L., Shiklomanov, A. I., Shiklomanov, N. I., Siegel, D. A., Signorini, S. R., Sima, F., Simmons, A. J., Smeets, C. J. P. P., Smith, S. L., Spence, J. M., Srivastava, A. K., Stackhouse, P. W., Stammerjohn, S., Steinbrecht, W., Stella, J. L., Stengel, M., Stennett-Brown, R., Stephenson, T. S., Strahan, S., Streletskiy, D. A., Sun-Mack, S., Swart, S., Sweet, W., Talley, L. D., Tamar, G., Tank, S. E., Taylor, M. A., Tedesco, M., Teubner, K., Thoman, R. L., Thompson, P., Thomson, L., Timmermans, M. L., Maxim Timofeyev, Tirnanes, J. A., Tobin, S., Trachte, K., Trainer, V. L., Tretiakov, M., Trewin, B. C., Trotman, A. R., Tschudi, M., As, D., Wal, R. S. W., A, R. J., Schalie, R., Schrier, G., Werf, G. R., Meerbeeck, C. J., Velicogna, I., Verburg, P., Vigneswaran, B., Vincent, L. A., Volkov, D., Vose, R. S., Wagner, W., Wåhlin, A., Wahr, J., Walsh, J., Wang, C., Wang, J., Wang, L., Wang, M., Wang, S. H., Wanninkhof, R., Watanabe, S., Weber, M., Weller, R. A., Weyhenmeyer, G. A., Whitewood, R., Wijffels, S. E., Wilber, A. C., Wild, J. D., Willett, K. M., Williams, M. J. M., Willie, S., Wolken, G., Wong, T., Wood, E. F., Woolway, R. I., Wouters, B., Xue, Y., Yamada, R., Yim, S. Y., Yin, X., Young, S. H., Yu, L., Zahid, H., Zambrano, E., Zhang, P., Zhao, G., Zhou, L., Ziemke, J. R., Love-Brotak, S. E., Gilbert, K., Maycock, T., Osborne, S., Sprain, M., Veasey, S. W., Ambrose, B. J., Griffin, J., Misch, D. J., Riddle, D. B., Young, T., Macias Fauria, M, Blunden, J, Arndt, D, Earth and Climate, Faculty of Earth and Life Sciences, Clinical Developmental Psychology, Climate Change and Landscape Dynamics, and Molecular Cell Physiology

Subjects
Meteor (satellite), Atmospheric Science, 010504 meteorology & atmospheric sciences, 0208 environmental biotechnology, 02 engineering and technology, 01 natural sciences, 020801 environmental engineering, Geography, 13. Climate action, Climatology, SDG 13 - Climate Action, SDG 14 - Life Below Water, 0105 earth and related environmental sciences
Abstract

In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 +/- 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 +/- 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44 degrees C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0 degrees C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8 degrees C, representing a 3.5 degrees C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute similar to 7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01 degrees C. The global sea surface temperature trend for the 21st century-to-date of +0.162 degrees C decade(-1) is much higher than the longer term 1950-2016 trend of +0.100 degrees C decade(-1). Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Nino at the beginning of the year that transitioned to a weak La Nina contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.

Published
2017

5. Diversifying the use of tuna to improve food security and public health in Pacific Island countries and territories

Author

Bell, J. D., Allain, V., Allison, E. H., Andréfouët, Serge, Andrew, N. L., Batty, M. J., Blanc, M., Dambacher, J. M., Hampton, J., Hanich, Q., Harley, S., Lorrain, Anne, McCoy, M., McTurk, N., Nicol, S., Pilling, G., Point, David, Sharp, M. K., Vivili, P., and Williams, P.

Subjects
Tuna, Population growth, Food security, Non-communicable diseases, Pacific Islands
Abstract

The large tuna resources of the Western and Central Pacific Ocean are delivering great economic benefits to Pacific Island countries and territories (PICTs) through sale of licences to distant water fishing nations and employment in fish processing. However, tuna needs to contribute to Pacific Island societies in another important way by increasing local access to the fish required for good nutrition to help combat the world's highest levels of diabetes and obesity. Analyses reported here demonstrate that coastal fisheries in 16 of the 22 PICTs will not provide the fish recommended for good nutrition of growing Pacific Island populations, and that by 2020 tuna will need to supply 12% of the fish required by PICTs for food security, increasing to 25% by 2035. In relative terms, the percentages of the region's tuna catch that will be needed in 2020 and 2035 to fill the gap in domestic fish supply are small, i.e., 2.1% and 5.9% of the average present-day industrial catch, respectively. Interventions based on expanding the use of nearshore fish aggregating devices (FADs) to assist small-scale fishers catch tuna, distributing small tuna and bycatch offloaded by industrial fleets at regional ports, and improving access to canned tuna for inland populations, promise to increase access to fish for sustaining the health of the region's growing populations. The actions, research and policies required to implement these interventions effectively, and the investments needed to maintain the stocks underpinning the considerable socio-economic benefits that flow from tuna, are described.

Published
2015

6. Guidance on risk assessment for animal welfare

Author

Sanaa, M., Broom, D., Keeling, Linda, Szücs, E, Oltenacu, Pascal A., Webster, J, More, S, Morton, D., Algers, Bo, Salman, M., Velarde, A., Sharp, M, Hartung, J., Thulke, H-H, Vannier, P., Wierup, Martin, Aiassa, Elisa, and Ribó, Oriol

Subjects
Agricultural Science
Abstract

The document provides methodological guidance to assess risks for animal welfare, considering the various husbandry systems, management procedures and the different animal welfare issues. The terminology for the risk assessment of animal welfare is described. Risk assessment should not be carried out unless the relevant welfare problem is clearly specified and formulated. The major components of the problem formulation are the description of the exposure scenario, the target population and the conceptual model linking the relevant factors of animal welfare concern. The formal risk assessment consists of exposure assessment, consequence characterisation, and risk characterisation. The systematic evaluation of the various aspects and components of the assessment procedure aims at ensuring its consistency. All assumptions used in problem formulation and risk assessment need to be clear. This also applies to uncertainty and variability in the various steps of the risk assessment. The choice between qualitative, semi-qualitative or quantitative approaches should be made based on the purpose or the type of questions to be answered, data, and resource availability for a specific risk assessment. Quantitative data should be used whenever possible. Positive effects on welfare (benefit) could be handled within the framework of risk assessment if the analysis considers factors as having both positive and negative effects on animal welfare. The last section details the main components of risk assessment documentation.

Published
2012

7. Galaxy Clusters at z>=1: Gas Constraints from the Sunyaev-Zel'dovich Array

Author

Culverhouse, T. L., Bonamente, M., Bulbul, E., Carlstrom, J. E., Gralla, M. B., Greer, C., Hasler, N., Hawkins, D., Hennessy, R., Jetha, N. N., Joy, M., Lamb, J. W., Leitch, E. M., Marrone, D. P., Miller, A., Mroczkowski, T., Muchovej, S., Pryke, C., Sharp, M., Woody, D., Andreon, S., Maughan, B., and Stanford, S. A.

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics
Abstract

We present gas constraints from Sunyaev-Zel'dovich (SZ) effect measurements in a sample of eleven X-ray and infrared (IR) selected galaxy clusters at z >=1, using data from the Sunyaev-Zel'dovich Array (SZA). The cylindrically integrated Compton-y parameter, Y , is calculated by fitting the data to a two-parameter gas pressure profile. Where possible, we also determine the temperature of the hot intra-cluster plasma from Chandra and XMM-Newton data, and constrain the gas mass within the same aperture (r_2500 ) as Y . The SZ effect is detected in the clusters for which the X-ray data indicate gas masses above ~ 10^13 Msun, including XMMU J2235-2557 at redshift z = 1.39, which to date is one of the most distant clusters detected using the SZ effect. None of the IR-selected targets are detected by the SZA measurements, indicating low gas masses for these objects. For these and the four other undetected clusters, we quote upper limits on Y and Mgas_SZ , with the latter derived from scaling relations calibrated with lower redshift clusters. We compare the constraints on Y and X-ray derived gas mass Mgas_X-ray to self-similar scaling relations between these observables determined from observations of lower redshift clusters, finding consistency given the measurement error., 6 pages, 2 figures, submitted on ApJL

Published
2010
Full Text
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8. Unsteady Water Flow in a Glacier Conduit

Author

Szilder, K., Lozowski, E. P., and Sharp, M.

Abstract

Changing Glaciers: Revisiting Themes and Field Sites of Classical Glaciology, available, unclassified, unlimited

Published
2009

10. Direct effect of ice sheets on terrestrial bicarbonate, sulphate and base cation fluxes during the last glacial cycle: minimal impact on atmospheric CO2 concentrations

Author

Martyn Tranter, Philippe Huybrechts, Guy Munhoven, Sharp, M. J., Brown, G. H., Jones, I. W., Hodson, A. J., Hodgkins, R., Wadhams, J. L., Physical Geography, and Vrije Universiteit Brussel

Abstract

Chemical erosion in glacial environments is normally a consequence of chemical weathering reactions dominated bysulphide oxidation linked to carbonate dissolution and the carbonation of carbonates and silicates. Solute fluxes from small valley glaciers are usually a linear function of discharge. Representative glacial solute concentrations can be derived from the linear association of solute flux with discharge. These representative glacial concentrations of the major ions are =25% of those in global river water. A 3-D thermomechanically coupled model of the growth and decay of the Northern Hemisphere ice sheets was used to simulate glacial runoff at 100-year time steps during the last glacial cycle (130 ka to the present). The glacially derived fluxes of major cations, anions and Si over the glaciation were estimated from the product of the glacial runoff and the representative glacial concentration. A second estimate was obtained from the product of the glacial runoff and a realistic upper limit for glacial solute concentrations derived from theoretical considerations. The fluxes over the last glacial cycle are usually less than a few percent of current riverine solute fluxes to the oceans. The glacial fluxes were used to provide input to an oceanic carbon cycling model that also calculates changes in atmospheric CO2 . The potential change in atmospheric CO2 concentrations over the last glacial cycle that arise from perturbations in glacial solute fluxes are insignificant, being

Published
2002

11. Correspondence

Author

Buckley-Sharp M

Subjects
media_common.quotation_subject, Applied psychology, Personality, General Medicine, Personality Assessment Inventory, Psychology, Education, media_common
Published
1992

12. Development of effective subunit vaccines against enveloped viruses

Author

Kai Simons, Helenius A, Morein B, Balcorova J, and Sharp M

Subjects
Mice, Mice, Inbred BALB C, Animals, Encephalitis, Membrane Proteins, Viral Vaccines, Antibodies, Viral, Antigens, Viral, Semliki forest virus, Glycoproteins, Parainfluenza Virus 3, Human
Published
1980

13. International division of labour programme; structural adjustment in the United Kingdom manufacturing industry

Author

Sharp M, Sheperd G, and Marsden D

Subjects
WEP pub, structural change, UK, technological change, private sector, manufacturing, cotton, electronics industry, motor vehicle industry, economic growth, productivity, competitiveness, collective bargaining, industrial policy, bibliography, statistical table, pub PME, changement structurel, Royaume-Uni, changement technologique, secteur privé, industries manufacturières, pub PME, cambio estructural, Reino Unido, cambio tecnológico, sector privado, industrias manufactureras, coton, industrie électronique, industrie du véhicule à moteur, croissance économique, productivité, compétitivité, négociation collective, politique industrielle, bibliographie, tableau statistique, algodón, industria electrónica, industria de vehículos a motor, crecimiento económico, productividad, competitividad, negociación colectiva, política industrial, bibliografía, cuadros estadísticos
Abstract

ILO pub-WEP pub. Working paper on structural change in the UK, regarding technological change in private sector manufacturing - gives examples from the cotton industry, the domestic electronics industry and the motor vehicle industry; considers economic growth, productivity, competitiveness, collective bargaining and industrial policy. Bibliography and statistical tables.

Published
1983

14. Effect of prostaglandin F2 alpha on human parathyroid adenomas: evidence for uncoupling of parathyroid hormone secretion and cAMP accumulation

Author

Gerald D. Aurbach, Sharp M, Martin C, Jeffrey A. Norton, and Lorraine A. Fitzpatrick

Subjects
Adenoma, medicine.medical_specialty, Epinephrine, Endocrinology, Diabetes and Metabolism, Parathyroid hormone, Biology, medicine.disease_cause, Pertussis toxin, Dinoprost, Internal medicine, Extracellular, medicine, Cyclic AMP, Tumor Cells, Cultured, Humans, Orthopedics and Sports Medicine, Virulence Factors, Bordetella, Receptor, Adenosine Diphosphate Ribose, Toxin, Isoproterenol, medicine.disease, Prostaglandin F2alpha, Endocrinology, Parathyroid Neoplasms, Pertussis Toxin, Parathyroid Hormone, Parathyroid hormone secretion, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Human parathyroid adenomas are aberrantly regulated by extracellular calcium. We tested pertussis toxin, which ADP-ribosylates and inactivates several guanine nucleotide regulatory proteins, to test the role of these proteins in the secretory control of adenomatous parathyroid tissue. Pertussis toxin did not affect basal cAMP accumulation in 12 adenomas and enhanced parathyroid hormone (PTH) release in 6 of 10 adenomas. Prostaglandin F2 alpha (PGF2 alpha) inhibited cAMP in three of six adenomas, and pertussis toxin pretreatment did not affect this result. PTH release in 7 of 10 adenomas was inhibited by PGF2 alpha, and pertussis toxin did not significantly alter PTH release. Pertussis toxin catalyzed ADP-ribosylation of a 40-kDa protein in all adenomas tested (n = 8). We conclude that cAMP accumulation was not affected by pertussis toxin but that in 6 of 10 adenomas, the toxin enhanced PTH release. We suggest that cAMP accumulation and PTH release may be uncoupled from negative control by inhibitory ligands in adenomatous tissue or that the G-proteins involved do not couple to regulatory receptors or to effector.

Published
1988

18. State of the Climate in 2012 INTRODUCTION

Author

Achberger, Christine, Ackerman, Stephen A., Albanil, Adelina, Alexander, P., Alfaro, Eric J., Allan, Rob, Alves, Lincoln M., Amador, Jorge A., Ambenje, Peter, Andrianjafinirina, Solonomenjanahary, Antonov, John, Aravequia, Jose A., Arendt, A., Arevalo, Juan, Arndt, Derek S., Ashik, I., Atheru, Zachary, Banzon, Viva, Baringer, Molly O., Barreira, Sandra, Barriopedro, David E., Beard, Grant, Becker, Andreas, Behrenfeld, Michael J., Bell, Gerald D., Benedetti, Angela, Bernhard, Germar, Berrisford, Paul, Berry, David I., Bhatt, U., Bidegain, Mario, Bindoff, Nathan, Bissolli, Peter, Blake, Eric S., Blunden, Jessica, Booneeady, Raj, Bosilovich, Michael, Box, J. E., Boyer, Tim, Braathen, Geir O., Bromwich, David H., Brown, R., Brown, L., Bruhwiler, Lori, Bulygina, Olga N., Burgess, D., Burrows, John, Calderon, Blanca, Camargo, Suzana J., Campbell, Jayaka, Cao, Y., Cappelen, J., Carrasco, Gualberto, Chambers, Don P., Chang A, L., Chappell, Petra, Chehade, Wissam, Cheliah, Muthuvel, Christiansen, Hanne H., Christy, John R., Ciais, Phillipe, Coelho, Caio A. S., Cogley, J. G., Colwell, Steve, Cross, J. N., Crouch, Jake, Cunningham, Stuart A., Dacic, Milan, Jeu, Richard A. M., Dekaa, Francis S., Demircan, Mesut, Derksen, C., Diamond, Howard J., Dlugokencky, Ed J., Dohan, Kathleen, Dolman, A. Johannes, Domingues, Catia M., Dong Shenfu, Dorigo, Wouter A., Drozdov, D. S., Duguay, Claude R., Dunn, Robert J. H., Duran-Quesada, Ana M., Dutton, Geoff S., Ehmann, Christian, Elkins, James W., Euscategui, Christian, Famiglietti, James S., Fang Fan, Fauchereau, Nicolas, Feely, Richard A., Fekete, Balazs M., Fenimore, Chris, Fioletov, Vitali E., Fogarty, Chris T., Fogt, Ryan L., Folland, Chris K., Foster, Michael J., Frajka-Williams, Eleanor, Franz, Bryan A., Frith, Stacey H., Frolov, I., Ganter, Catherine, Garzoli, Silvia, Geai, M. -L, Gerland, S., Gitau, Wilson, Gleason, Karin L., Gobron, Nadine, Goldenberg, Stanley B., Goni, Gustavo, Good, Simon A., Gottschalck, Jonathan, Gregg, Margarita C., Griffiths, Georgina, Grooss, Jens-Uwe, Guard, Charles Chip, Gupta, Shashi K., Hall, Bradley D., Halpert, Michael S., Harada, Yayoi, Hauri, C., Heidinger, Andrew K., Heikkila, Anu, Heim, Richard R., Heimbach, Patrick, Hidalgo, Hugo G., Hilburn, Kyle, Ho, Shu-Peng, Hobbs, Will R., Holgate, Simon, Hovsepyan, Anahit, Hu Zeng-Zhen, Hughes, P., Hurst, Dale F., Ingvaldsen, R., Inness, Antje, Jaimes, Ena, Jakobsson, Martin, James, Adamu I., Jeffries, Martin O., Johns, William E., Johnsen, Bjorn, Johnson, Gregory C., Johnson, Bryan, Jones, Luke T., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, Johannes W., Kamga, Andre, Kang, Kyun-Kuk, Kanzow, Torsten O., Kao, Hsun-Ying, Keller, Linda M., Kennedy, John J., Key, J., Khatiwala, Samar, Pour, H. Kheyrollah, Kholodov, A. L., Khoshkam, Mahbobeh, Kijazi, Agnes, Kikuchi, T., Kim, B. -M, Kim, S. -J, Kimberlain, Todd B., Knaff, John A., Korshunova, Natalia N., Koskela, T., Kousky, Vernon E., Kramarova, Natalya, Kratz, David P., Krishfield, R., Kruger, Andries, Kruk, Michael C., Kumar, Arun, Lagerloef, Gary S. E., Lakkala, K., Lander, Mark A., Landsea, Chris W., Lankhorst, Matthias, Laurila, T., Lazzara, Matthew A., Lee, Craig, Leuliette, Eric, Levitus, Sydney, L Heureux, Michelle, Lieser, Jan, Lin, I-I, Liu, Y. Y., Liu, Y., Liu Hongxing, Liu Yanju, Lobato-Sanchez, Rene, Locarnini, Ricardo, Loeb, Norman G., Loeng, H., Long, Craig S., Lorrey, Andrew M., Luhunga, P., Lumpkin, Rick, Luo Jing-Jia, Lyman, John M., Macdonald, Alison M., Maddux, Brent C., Malekela, C., Manney, Gloria, Marchenko, S. S., Marengo, Jose A., Marotzke, Jochem, Marra, John J., Martinez-Gueingla, Rodney, Massom, Robert A., Mathis, Jeremy T., Mcbride, Charlotte, Mccarthy, Gerard, Mcvicar, Tim R., Mears, Carl, Meier, W., Meinen, Christopher S., Menendez, Melisa, Merrifield, Mark A., Mitchard, Edward, Mitchum, Gary T., Montzka, Stephen A., Morcrette, Jean-Jacques, Mote, Thomas, Muehle, Jens, Muehr, Bernhard, Mullan, A. Brett, Mueller, Rolf, Nash, Eric R., Nerem, R. Steven, Newlin, Michele L., Newman, Paul A., Ng Ongolo, H., Nieto, Juan Jose, Nishino, S., Nitsche, Helga, Noetzli, Jeannette, Oberman, N. G., Obregon, Andre, Ogallo, Laban A., Oludhe, Christopher S., Omar, Mohamed I., Overland, James, Oyunjargal, Lamjav, Parinussa, Robert M., Park, Geun-Ha, Park, E-Hyung, Parker, David, Pasch, Richard J., Pascual-Ramirez, Reynaldo, Pelto, Mauri S., Penalba, Olga, Peng, L., Perovich, Don K., Pezza, Alexandre B., Phillips, David, Pickart, R., Pinty, Bernard, Pitts, Michael C., Purkey, Sarah G., Quegan, Shaun, Quintana, Juan, Rabe, B., Rahimzadeh, Fatemeh, Raholijao, Nirivololona, Raiva, I., Rajeevan, Madhavan, Ramiandrisoa, Voahanginirina, Ramos, Alexandre, Ranivoarissoa, Sahondra, Rayner, Nick A., Rayner, Darren, Razuveav, Vyacheslav N., Reagan, James, Reid, Phillip, Renwick, James, Revedekar, Jayashree, Richter-Menge, Jacqueline, Rivera, Ingrid L., Robinson, David A., Rodell, Matthew, Romanovsky, Vladimir E., Ronchail, Josyane, Karen Rosenlof, Sabine, Christopher L., Salvador, Mozar A., Sanchez-Lugo, Ahira, Santee, Michelle L., Sasgen, I., Sawaengphokhai, P., Sayouri, Amal, Scambos, Ted A., Schauer, U., Schemm, Jae, Schlosser, P., Schmid, Claudia, Schreck, Carl, Semiletov, Igor, Send, Uwe, Sensoy, Serhat, Setzer, Alberto, Severinghaus, Jeffrey, Shakhova, Natalia, Sharp, M., Shiklomanov, Nicolai I., Siegel, David A., Silva, Viviane B. S., Silva, Frabricio D. S., Sima, Fatou, Simeonov, Petio, Simmonds, I., Simmons, Adrian, Skansi, Maria, Smeed, David A., Smethie, W. M., Smith, Adam B., Smith, Cathy, Smith, Sharon L., Smith, Thomas M., Sokolov, V., Srivastava, A. K., Stackhouse, Paul W., Stammerjohn, Sharon, Steele, M., Steffen, Konrad, Steinbrecht, Wolfgang, Stephenson, Tannecia, Su, J., Svendby, T., Sweet, William, Takahashi, Taro, Tanabe, Raymond M., Taylor, Michael A., Tedesco, Marco, Teng, William L., Thepaut, Jean-Noel, Thiaw, Wassila M., Thoman, R., Thompson, Philip, Thorne, Peter W., Timmermans, M. -L, Tobin, Skie, Toole, J., Trewin, Blair C., Trigo, Ricardo M., Trotman, Adrian, Tschudi, M., Wal, Roderik S. W., Werf, Guido R., Vautard, Robert, Vazquez, J. L., Vieira, Goncalo, Vincent, Lucie, Vose, Russ S., Wagner, Wolfgang W., Wahr, John, Walsh, J., Wang Junhong, Wang Chunzai, Wang, M., Wang Sheng-Hung, Wang Lei, Wanninkhof, Rik, Weaver, Scott, Weber, Mark, Werdell, P. Jeremy, Whitewood, Robert, Wijffels, Susan, Wilber, Anne C., Wild, J. D., Willett, Kate M., Williams, W., Willis, Joshua K., Wolken, G., Wong, Takmeng, Woodgate, R., Worthy, D., Wouters, B., Wovrosh, Alex J., Xue Yan, Yamada, Ryuji, Yin Zungang, Yu Lisan, Zhang Liangying, Zhang Peiqun, Zhao Lin, Zhao, J., Zhong, W., Ziemke, Jerry, and Zimmermann, S.

19. VizieR Online Data Catalog: OzDES DR1 (Childress+, 2017)

Author

Childress, M. J., Lidman, C., Davis, T. M., Tucker, B. E., Asorey, J., Yuan, F., Abbott, T. M. C., Abdalla, F. B., Allam, S., Annis, J., Banerji, M., Benoit-Levy, A., Stephanie Bernard, Bertin, E., Brooks, D., Buckley-Geer, E., Burke, D. L., Rosell, A. Carnero, Carollo, D., Carrasco Kind, M., Carretero, J., Castander, F. J., Cunha, C. E., Costa, L. N. Da, D Andrea, C. B., Doel, P., Eifler, T. F., Evrard, A. E., Flaugher, B., Foley, R. J., Fosalba, P., Frieman, J., Garcia-Bellido, J., Glazebrook, K., Goldstein, D. A., Gruen, D., Gruendl, R. A., Gschwend, J., Gupta, R. R., Gutierrez, G., Hinton, S. R., Hoormann, J. K., James, D. J., Kessler, R., Kim, A. G., King, A. L., Kovacs, E., Kuehn, K., Kuhlmann, S., Kuropatkin, N., Lagattuta, D. J., Lewis, G. F., Li, T. S., Lima, M., Lin, H., Macaulay, E., Maia, M. A. G., Marriner, J., March, M., Marshall, J. L., Martini, P., Mcmahon, R. G., Menanteau, F., Miquel, R., Moller, A., Morganson, E., Mould, J., Mudd, D., Muthukrishna, D., Nichol, R. C., Nord, B., Ogando, R. L. C., Ostrovski, F., Parkinson, D., Plazas, A. A., Reed, S. L., Reil, K., Rome, R. A. K., Rykoff, E. S., Sako, M., Sanchez, E., Scarpine, V., Schindler, R., Schubnell, M., Scolnic, I. D., Sevilla-Noarbe, N., Seymour, R., Sharp, M., Smith, M., Soares-Santos, F., Sobreira, Sommer, N. E., Spinka, H., Suchyta, E., Sullivan, M., Swanson, M. E. C., Tarle, G., Uddin, S. A., Walker, A. R., Wester, W., and Zhang, B. R.

20. LEAP projects: Concept and challenges

Author

Manzari, M. T., Kutter, B. L., Zeghal, M., Iai, S., Tobita, T., Santana Phani Gopal Madabhushi, Haigh, S. K., Mejia, L., Gutierrez, D. A., Armstrong, R. J., Sharp, M. K., Chen, Y. M., and Zhou, Y. G.

21. State of the climate in 2017

Author

Abernethy, R., Ackerman, S. A., Adler, R., Albanil Encarnación, A., Aldeco, L. S., Alfaro, E. J., Aliaga-Nestares, V., Allan, R. P., Allan, R., Alves, L. M., Amador, J. A., Anderson, J., Andreassen, L. M., Argüez, A., Armitage, C., Arndt, D. S., Avalos, G., Azorin-Molina, C., Báez, J., Bardin, M. Yu, Barichivich, J., Baringer, M. O., Barreira, S., Baxter, S., Beck, H. E., Becker, A., Bedka, K. M., Behe, C., Bell, G. D., Bellouin, N., Belmont, M., Benedetti, A., Bernhard, G. H., Berrisford, P., Berry, D. I., Bhatt, U. S., Bissolli, P., Bjerke, J., Blake, E. S., Blenkinsop, S., Blunden, J., Bolmgren, K., Bosilovich, M. G., Boucher, O., Bouchon, M., Box, J. E., Boyer, T., Braathen, G. O., Bromwich, D. H., Brown, R., Buehler, S., Bulygina, O. N., Burgess, D., Calderón, B., Camargo, S. J., Campbell, E. C., Campbell, J. D., Cappelen, J., Carrea, L., Carter, B. R., Castro, A., Chambers, D. P., lijing cheng, Christiansen, H. H., Christy, J. R., Chung, E. -S, Clem, K. R., Coelho, C. A. S., Coldewey-Egbers, M., Colwell, S., Cooper, O. R., Copland, L., Costanza, C., Covey, C., Coy, L., Cronin, T., Crouch, J., Cruzado, L., Daniel, R., Davis, S. M., Davletshin, S. G., Eyto, E., Jeu, R. A. M., La Cour, J. L., Laat, J., Gasperi, C. L., Degenstein, D., Deline, P., Demircan, M., Derksen, C., Dewitte, B., Dhurmea, R., Di Girolamo, L., Diamond, H. J., Dickerson, C., Dlugokencky, E. J., Dohan, K., Dokulil, M. T., Dolman, A. J., Domingues, C. M., Domingues, R., Donat, M. G., Dong, S., Dorigo, W. A., Drozdov, D. S., Dunn, R. J. H., Durre, I., Dutton, G. S., Eakin, C. M., El Kharrim, M., Elkins, J. W., Epstein, H. E., Espinoza, J. C., Famiglietti, J. S., Farmer, J., Farrell, S., Fauchald, P., Fausto, R. S., Feely, R. A., Feng, Z., Fenimore, C., Fettweis, X., Fioletov, V. E., Flemming, J., Fogt, R. L., Folland, C., Forbes, B. C., Foster, M. J., Francis, S. D., Franz, B. A., Frey, R. A., Frith, S. M., Froidevaux, L., Ganter, C., Geiger, E. F., Gerland, S., Gilson, J., Gobron, N., Goldenberg, S. B., Gomez, A. M., Goni, G., Grooß, J. U., Gruber, A., Guard, C. P., Gugliemin, M., Gupta, S. K., Gutiérrez, D., Haas, C., Hagos, S., Hahn, S., Haimberger, L., Hall, B. D., Halpert, M. S., Hamlington, B. D., Hanna, E., Hansen, K., Hanssen-Bauer, L., Harris, I., Hartfield, G., Heidinger, A. K., Heim, R. R., Helfrich, S., Hemming, D. L., Hendricks, S., Hernández, R., Hernández, S. M., Heron, S. F., Heuzé, C., Hidalgo, H. G., Ho, S. -P, Hobbs, W. R., Horstkotte, T., Huang, B., Hubert, D., Hueuzé, C., Hurst, D. F., Ialongo, I., Ibrahim, M. M., Ijampy, J. A., Inness, A., Isaac, V., Isaksen, K., Ishii, M., Jacobs, S. J., Jeffries, M. O., Jevrejeva, S., Jiménez, C., Jin, X., John, V., Johns, W. E., Johnsen, B., Johnson, B., Johnson, G. C., Johnson, K. S., Jones, P. D., Jumaux, G., Kabidi, K., Kaiser, J. W., Karaköylü, E. M., Kato, S., Kazemi, A., Keller, L. M., Kennedy, J., Kerr, K., Khan, M. S., Kholodov, A. L., Khoshkam, M., Killick, R., Kim, H., Kim, S. -J, Klotzbach, P. J., Knaff, J. A., Kohler, J., Korhonen, J., Korshunova, N. N., Kramarova, N., Kratz, D. P., Kruger, A., Kruk, M. C., Krumpen, T., Ladd, C., Lakatos, M., Lakkala, K., Lander, M. A., Landschützer, P., Landsea, C. W., Lankhorst, M., Lavado-Casimiro, W., Lazzara, M. A., Lee, S. -E, Lee, T. C., Leuliette, E., L Heureux, M., Li, T., Lieser, J. L., Lin, I. -I, Mears, C. A., Liu, G., Li, B., Liu, H., Locarnini, R., Loeb, N. G., Long, C. S., López, L. A., Lorrey, A. M., Loyola, D., Lumpkin, R., Luo, J. -J, Luojus, K., Luthcke, S., Macias-Fauria, M., Malkova, G. V., Manney, G. L., Marcellin, V., Marchenko, S. S., Marengo, J. A., Marín, D., Marra, J. J., Marszelewski, W., Martens, B., Martin, A., Martínez, A. G., Martínez-Güingla, R., Martínez-Sánchez, O., Marsh, B. L., Lyman, J. M., Massom, R. A., May, L., Mayer, M., Mazloff, M., Mcbride, C., Mccabe, M. F., Mccarthy, M., Meier, W., Meijers, A. J. S., Mekonnen, A., Mengistu Tsidu, G., Menzel, W. P., Merchant, C. J., Meredith, M. P., Merrifield, M. A., Miller, B., Miralles, D. G., Mitchum, G. T., Mitro, S., Moat, B., Mochizuki, Y., Monselesan, D., Montzka, S. A., Mora, N., Morice, C., Mosquera-Vásquez, K., Mostafa, A. E., Mote, T., Mudryk, L., Mühle, J., Mullan, A. B., Müller, R., Myneni, R., Nash, E. R., Nerem, R. S., Newman, L., Newman, P. A., Nielsen-Gammon, J. W., Nieto, J. J., Noetzli, J., Noll, B. E., O Neel, S., Osborn, T. J., Osborne, E., Overland, J., Oyunjargal, L., Park, T., Pasch, R. J., Pascual-Ramírez, R., Pastor Saavedra, M. A., Paterson, A. M., Paulik, C., Pearce, P. R., Peltier, A., Pelto, M. S., Peng, L., Perkins-Kirkpatrick, S. E., Perovich, D., Petropavlovskikh, I., Pezza, A. B., Phillips, C., Phillips, D., Phoenix, G., Pinty, B., Pinzon, J., Po-Chedley, S., Polashenski, C., Purkey, S. G., Quispe, N., Rajeevan, M., Rakotoarimalala, C., Rayner, D., Raynolds, M. K., Reagan, J., Reid, P., Reimer, C., Rémy, S., Revadekar, J. V., Richardson, A. D., Richter-Menge, J., Ricker, R., Rimmer, A., Robinson, D. A., Rodell, M., Rodriguez Camino, E., Romanovsky, V. E., Ronchail, J., Rosenlof, K. H., Rösner, B., Roth, C., Roth, D. M., Rusak, J. A., Rutishäuser, T., Sallée, J. -B, Sánchez-Lugo, A., Santee, M. L., Sasgen, L., Sawaengphokhai, P., Sayad, T. A., Sayouri, A., Scambos, T. A., Scanlon, T., Schenzinger, V., Schladow, S. G., Schmid, C., Schmid, M., Schreck, C. J., Selkirk, H. B., Send, U., Sensoy, S., Sharp, M., Shi, L., Shiklomanov, N. I., Shimaraeva, S. V., Siegel, D. A., Silow, E., Sima, F., Simmons, A. J., Skirving, W. J., Smeed, D. A., Smeets, C. J. P. P., Smith, A., Smith, S. L., Soden, B., Sofieva, V., Sparks, T. H., Spence, J. M., Spillane, S., Srivastava, A. K., Stackhouse, P. W., Stammerjohn, S., Stanitski, D. M., Steinbrecht, W., Stella, J. L., Stengel, M., Stephenson, K., Stephenson, T. S., Strahan, S., Streletskiy, D. A., Strong, A. E., Sun-Mack, S., Sutton, A. J., Swart, S., Sweet, W., Takahashi, K. S., Tamar, G., Taylor, M. A., Tedesco, M., Thackeray, S. J., Thoman, R. L., Thompson, P., Thomson, L., Thorsteinsson, T., Timbal, B., Timmermans, M. -L, Timofeyev, M. A., Tirak, K. V., Tobin, S., Togawa, H., Tømmervik, H., Tourpali, K., Trachte, K., Trewin, B. C., Triñanes, J. A., Trotman, A. R., Tschudi, M., Tucker, C. J., Tye, M. R., As, D., Wal, R. S. W., Ronald, J. A., Schalie, R., Schrier, G., Werf, G. R., Meerbeeck, C. J., Velden, C. S., Velicogna, I., Verburg, P., Vickers, H., Vincent, L. A., Vömel, H., Vose, R. S., Wagner, W., Walker, D. A., Walsh, J., Wang, B., Wang, J., Wang, L., Wang, M., Wang, R., Wang, S. -H, Wanninkhof, R., Watanabe, S., Weber, M., Webster, M., Weller, R. A., Westberry, T. K., Weyhenmeyer, G. A., Whitewood, R., Widlansky, M. J., Wiese, D. N., Wijffels, S. E., Wilber, A. C., Wild, J. D., Willett, K. M., Willis, J. K., Wolken, G., Wong, T., Wood, E. F., Wood, K., Woolway, R. I., Wouters, B., Xue, Y., Yin, X., Yoon, H., York, A., Yu, L., Zambrano, E., Zhang, H. -M, Zhang, P., Zhao, G., Zhao, L., Zhu, Z., Ziel, R., Ziemke, J. R., Ziese, M. G., Griffin, J., Hammer, G., Love-Brotak, S. E., Misch, D. J., Riddle, D. B., Slagle, M., Sprain, M., Veasey, S. W., and Mcvicar, T. R.

Subjects
Meteor (satellite), Atmospheric Science, Climate Research, 010504 meteorology & atmospheric sciences, Climate change, 010501 environmental sciences, 01 natural sciences, SDG 11 - Sustainable Cities and Communities, Klimatforskning, El Niño Southern Oscillation, 13. Climate action, Climatology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Environmental science, SDG 14 - Life Below Water, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 0105 earth and related environmental sciences
Abstract

In 2017, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-reached new record highs. The annual global average carbon dioxide concentration at Earth's surface for 2017 was 405.0 ± 0.1 ppm, 2.2 ppm greater than for 2016 and the highest in the modern atmospheric measurement record and in ice core records dating back as far as 800 000 years. The global growth rate of CO2 has nearly quadrupled since the early 1960s. With ENSO-neutral conditions present in the central and eastern equatorial Pacific Ocean during most of the year and weak La Niña conditions notable at the start and end, the global temperature across land and ocean surfaces ranked as the second or third highest, depending on the dataset, since records began in the mid-to-late 1800s. Notably, it was the warmest non-El Niño year in the instrumental record. Above Earth's surface, the annual lower tropospheric temperature was also either second or third highest according to all datasets analyzed. The lower stratospheric temperature was about 0.2°C higher than the record cold temperature of 2016 according to most of the in situ and satellite datasets. Several countries, including Argentina, Uruguay, Spain, and Bulgaria, reported record high annual temperatures. Mexico broke its annual record for the fourth consecutive year. On 27 January, the temperature reached 43.4°C at Puerto Madryn, Argentina-the highest temperature recorded so far south (43°S) anywhere in the world. On 28 May in Turbat, western Pakistan, the high of 53.5°C tied Pakistan's all-time highest temperature and became the world-record highest temperature for May. In the Arctic, the 2017 land surface temperature was 1.6°C above the 1981-2010 average, the second highest since the record began in 1900, behind only 2016. The five highest annual Arctic temperatures have all occurred since 2007. Exceptionally high temperatures were observed in the permafrost across the Arctic, with record values reported in much of Alaska and northwestern Canada. In August, high sea surface temperature (SST) records were broken for the Chukchi Sea, with some regions as warm as +11°C, or 3° to 4°C warmer than the longterm mean (1982-present). According to paleoclimate studies, today's abnormally warm Arctic air and SSTs have not been observed in the last 2000 years. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 7 March, sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, covering 8% less area than the 1981-2010 average. The Arctic sea ice minimum on 13 September was the eighth lowest on record and covered 25% less area than the long-term mean. Preliminary data indicate that glaciers across the world lost mass for the 38th consecutive year on record; the declines are remarkably consistent from region to region. Cumulatively since 1980, this loss is equivalent to slicing 22 meters off the top of the average glacier. Antarctic sea ice extent remained below average for all of 2017, with record lows during the first four months. Over the continent, the austral summer seasonal melt extent and melt index were the second highest since 2005, mostly due to strong positive anomalies of air temperature over most of the West Antarctic coast. In contrast, the East Antarctic Plateau saw record low mean temperatures in March. The year was also distinguished by the second smallest Antarctic ozone hole observed since 1988. Across the global oceans, the overall long-term SST warming trend remained strong. Although SST cooled slightly from 2016 to 2017, the last three years produced the three highest annual values observed; these high anomalies have been associated with widespread coral bleaching. The most recent global coral bleaching lasted three full years, June 2014 to May 2017, and was the longest, most widespread, and almost certainly most destructive such event on record. Global integrals of 0-700-m and 0-2000-m ocean heat content reached record highs in 2017, and global mean sea level during the year became the highest annual average in the 25-year satellite altimetry record, rising to 77 mm above the 1993 average. In the tropics, 2017 saw 85 named tropical storms, slightly above the 1981-2010 average of 82. The North Atlantic basin was the only basin that featured an above-normal season, its seventh most active in the 164-year record. Three hurricanes in the basin were especially notable. Harvey produced record rainfall totals in areas of Texas and Louisiana, including a storm total of 1538.7 mm near Beaumont, Texas, which far exceeds the previous known U.S. tropical cyclone record of 1320.8 mm. Irma was the strongest tropical cyclone globally in 2017 and the strongest Atlantic hurricane outside of the Gulf of Mexico and Caribbean on record with maximum winds of 295 km h-1. Maria caused catastrophic destruction across the Caribbean Islands, including devastating wind damage and flooding across Puerto Rico. Elsewhere, the western North Pacific, South Indian, and Australian basins were all particularly quiet. Precipitation over global land areas in 2017 was clearly above the long-term average. Among noteworthy regional precipitation records in 2017, Russia reported its second wettest year on record (after 2013) and Norway experienced its sixth wettest year since records began in 1900. Across India, heavy rain and flood-related incidents during the monsoon season claimed around 800 lives. In August and September, above-normal precipitation triggered the most devastating floods in more than a decade in the Venezuelan states of Bolívar and Delta Amacuro. In Nigeria, heavy rain during August and September caused the Niger and Benue Rivers to overflow, bringing floods that displaced more than 100 000 people. Global fire activity was the lowest since at least 2003; however, high activity occurred in parts of North America, South America, and Europe, with an unusually long season in Spain and Portugal, which had their second and third driest years on record, respectively. Devastating fires impacted British Columbia, destroying 1.2 million hectares of timber, bush, and grassland, due in part to the region's driest summer on record. In the United States, an extreme western wildfire season burned over 4 million hectares; the total costs of $18 billion tripled the previous U.S. annual wildfire cost record set in 1991.

24. Is knife seizure imagery an effective crime deterrent? A multi-method study

Author

Nicola Cogan, Chin-Van Chau, Y., Kirsten Russell, Linden, W., Swinson, N., Petya Eckler, Keith Lee Knifton, Jordan, V., Damien John Williams, Carney, S., Sharp, M., and Hunter, S. C.

Subjects
HV7231
Abstract

The urgency to reduce knife carrying has been recognised by the police services in Scotland and has been addressed by the introduction of various initiatives to deter knife carrying and crime. One tactic includes the sharing of knife seizure images, where pictures of knives recovered by police are shared on media outlets, however, little research has explored whether this is an effective deterrent. The study sought to explore adults' views of the use of knife images as a deterrent to carrying knives utilising a multi-method approach: (1) a cross-sectional online survey (n= 553), and (2) individual, online semi-structured interviews with adults (n = 20). Fearful, worried and angry reactions towards the use of knife seizure images were expressed among adults and concern was raised that the use of such images may reinforce rather than deter knife carrying. Adults expressed concerns that the use of such images served to reinforce negative stereotypes and stigma within communities affected by high knife crime. The implications of these findings emphasise the limitations to the use of knife seizure images as a deterrent against knife carrying and the importance of community involvement in developing preventative and non-discriminatory approaches to tackling knife carrying throughout Scotland.

28. Student Breakdown

Author

Buckley-Sharp, M D

Subjects
Adult, Motivation, Students, Medical, Adolescent, Depression, Humans, General Medicine, Stress, Psychological, United Kingdom, Research Article
Published
1978

29. Laser Surface Texturing To Create Biomimetic Surface Topographies For Marine Antifouling Efficacy Testing

Author

Horner, R, Sharp, M, and Durr, S

Subjects
TA, VM
Abstract

Biofouling is the unwanted colonisation of organisms on a living or artificial surface. Convergent evolution has led to the development of antifouling textures on many marine species. This thesis provides novel investigation into creating biomimetic antifouling surface directly onto marine grade stainless steel using laser micro machining. The investigation was split into three main research questions: (1) can laser surface texturing be used to create antifouling surfaces, and their effects on surface parameters (roughness / contact angle); (2) can biomimetic antifouling surfaces be created using laser surface texturing?; (3) can features of those successful surfaces be combined to create enhanced biomimetic antifouling surface?. All three experiments had similar methods, as laser processing was used to transfer the selected biomimetic micro-topography patterns onto marine grade stainless steel (316L). Samples were deployed in the field (Liverpool South Docks, UK) for 7 days. Abundance of biofilm was assessed using random systematic sampling. For the biomimetic surfaces, a fringe projection microscope (GFM) was used to investigate 3D scans of the surface topography of shells of bivalve and crab species, to provide bio-inspiration for the design of the surfaces created in this research. It was found that the micro-topography pattern limits the attachment of the biofilm to the surface. This thesis shows that (1) laser surface texturing can be used to create antifouling surfaces; (2) biomimetic antifouling surfaces can be created and enhance antifouling efficacy, and (3) that combining biomimetic features into multi-scale and multi-feature patterns have enhanced antifouling effects. This reinforces that biomimetic surfaces have the potential to be a non-toxic, eco-friendly antifouling technology that work directly on marine metal structures without the need for further coatings or chemicals.

Published
2020
Full Text
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31. The instrument suite of the European Spallation Source

Author

S. Stepanyan, F. Masi, Gergely Nagy, Henrich Frielinghaus, R. Kiehn, Richard Hall-Wilton, Stewart F. Parker, Judith E. Houston, C. Bovo, Uwe Filges, Joshaniel F. K. Cooper, Jochen Stahn, I. Herranz, R. Vivanco, Zahir Salhi, S. Klimko, A. Gussen, M. Huerta, Isabel Llamas-Jansa, S. Rodrigues, X. Fabrèges, Thomas Arnold, Esko Oksanen, Melissa Sharp, F. Porcher, F.Y. Moreira, Wiebke Lohstroh, N. Webb, F. Piscitelli, Paul Gregory Freeman, Roberto Senesi, S. Petersson Årsköld, Winfried Petry, Niels Bech Christensen, L. Di Fresco, Martin Müller, Henrik Carlsen, M. Magán, Jürg Schefer, K. Lieutenant, G. Laszlo, Kim Lefmann, Paul F. Henry, C. Scatigno, A. De Bonis, Artur Glavic, Jürgen Neuhaus, Robin Woracek, A. Goukassov, M. Rouijaa, Burkhard Schillinger, Přemysl Beran, H. Kämmerling, Richard K. Heenan, P. Lukáš, H. Wacklin-Knecht, A. Schwaab, Mads F. Bertelsen, Rasmus Toft-Petersen, Linda Udby, Marco Zanatta, Giuseppe Gorini, Ibon Bustinduy, Bjørn C. Hauback, O.G. del Moral, R.E. Lechner, M. Lerche, Th. Kittelmann, Ken Haste Andersen, M. A. Olsen, Henrik M. Rønnow, J.W. Taylor, J. Guyon Le Bouffy, Pascale P. Deen, Aureliano Tartaglione, J. Jestin, Sean Langridge, Ph. Schmakat, D.J. Siemers, D. Martín-Rodríguez, M. Morgano, B. Annighöfer, C.I. Lopez, Oliver Kirstein, Mikhail Feygenson, M. Zanetti, S. Pullen, F. Sordo, S. Bellissima, Andrew Jackson, Francesco Sacchetti, J. Elmer, D. Mannix, P. Tozzi, Th. Robillard, A. Poqué, J. Fenske, Jemel P. Aguilar, M. Seifert, G. Fabrèges, E. Abad, J. Šaroun, A. Wischnewski, Félix J. Villacorta, Monika Hartl, Giuseppe Aprigliano, S. Schütz, Michael Schulz, Ch. Niedermayer, Elbio Calzada, Heloisa N. Bordallo, A. Heynen, Anna Fedrigo, M. Olsson, Sebastian Jaksch, Markus Strobl, Tadeusz Kozielewski, José Luis Martínez, Grzegorz Nowak, Mogens Christensen, Felix Fernandez-Alonso, S. Kennedy, A. Hiess, M.E. Hagen, A. Schreyer, Alessandro Paciaroni, Caterina Petrillo, M. Arai, P. Galsworthy, Jörg Voigt, Andrea Orecchini, G. Scionti, M. Mosconi, Ch. Alba-Simionesco, I. Stefanescu, Ralf Engels, S. Longeville, J. Nightingale, S. Desert, Márton Markó, H. Schneider, Kalliopi Kanaki, Stuart Ansell, Th. Brückel, M. A. H. Chowdhury, Daniele Colognesi, G. Bakedano, Ch. Klauser, D. Turner, M. Koenen, D. Raspino, K. Iversen, Sonja Holm-Dahlin, Dorothea Pfeiffer, P. Luna, Ferenc Mezei, L. del Rosso, Anette Vickery, Carla Andreani, Earl Babcock, Werner Schweika, J. O. Birk, Anton Khaplanov, U. Bengaard Hansen, Th. Dupont, William Halcrow, P. Harbott, Nikolaos Tsapatsaris, P. Lavie, Eberhard Lehmann, L. Whitelegg, Romuald Hanslik, A. Orszulik, S. Butterweck, R. Kolevatov, Ph. Bourges, Dimitri N. Argyriou, L. Loaiza, Nicolo Violini, LLB - Nouvelles frontières dans les matériaux quantiques (NFMQ), Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Laue-Langevin (ILL), ESS, Lund, Swedish Research Council, Centre National de la Recherche Scientifique (France), Science and Technology Facilities Council (UK), European Commission, ILL, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Andersen, K, Argyriou, D, Jackson, A, Houston, J, Henry, P, Deen, P, Toft-Petersen, R, Beran, P, Strobl, M, Arnold, T, Wacklin-Knecht, H, Tsapatsaris, N, Oksanen, E, Woracek, R, Schweika, W, Mannix, D, Hiess, A, Kennedy, S, Kirstein, O, Petersson Arskold, S, Taylor, J, Hagen, M, Laszlo, G, Kanaki, K, Piscitelli, F, Khaplanov, A, Stefanescu, I, Kittelmann, T, Pfeiffer, D, Hall-Wilton, R, Lopez, C, Aprigliano, G, Whitelegg, L, Moreira, F, Olsson, M, Bordallo, H, Martin-Rodriguez, D, Schneider, H, Sharp, M, Hartl, M, Nagy, G, Ansell, S, Pullen, S, Vickery, A, Fedrigo, A, Mezei, F, Arai, M, Heenan, R, Halcrow, W, Turner, D, Raspino, D, Orszulik, A, Cooper, J, Webb, N, Galsworthy, P, Nightingale, J, Langridge, S, Elmer, J, Frielinghaus, H, Hanslik, R, Gussen, A, Jaksch, S, Engels, R, Kozielewski, T, Butterweck, S, Feygenson, M, Harbott, P, Poque, A, Schwaab, A, Lieutenant, K, Violini, N, Voigt, J, Bruckel, T, Koenen, M, Kammerling, H, Babcock, E, Salhi, Z, Wischnewski, A, Heynen, A, Desert, S, Jestin, J, Porcher, F, Fabreges, X, Fabreges, G, Annighofer, B, Klimko, S, Dupont, T, Robillard, T, Goukassov, A, Longeville, S, Alba-Simionesco, C, Bourges, P, Guyon Le Bouffy, J, Lavie, P, Rodrigues, S, Calzada, E, Lerche, M, Schillinger, B, Schmakat, P, Schulz, M, Seifert, M, Lohstroh, W, Petry, W, Neuhaus, J, Loaiza, L, Tartaglione, A, Glavic, A, Schutz, S, Stahn, J, Lehmann, E, Morgano, M, Schefer, J, Filges, U, Klauser, C, Niedermayer, C, Fenske, J, Nowak, G, Rouijaa, M, Siemers, D, Kiehn, R, Muller, M, Carlsen, H, Udby, L, Lefmann, K, Birk, J, Holm-Dahlin, S, Bertelsen, M, Hansen, U, Olsen, M, Christensen, M, Iversen, K, Christensen, N, Ronnow, H, Freeman, P, Hauback, B, Kolevatov, R, Llamas-Jansa, I, Orecchini, A, Sacchetti, F, Petrillo, C, Paciaroni, A, Tozzi, P, Zanatta, M, Luna, P, Herranz, I, del Moral, O, Huerta, M, Magan, M, Mosconi, M, Abad, E, Aguilar, J, Stepanyan, S, Bakedano, G, Vivanco, R, Bustinduy, I, Sordo, F, Martinez, J, Lechner, R, Villacorta, F, Saroun, J, Lukas, P, Marko, M, Zanetti, M, Bellissima, S, del Rosso, L, Masi, F, Bovo, C, Chowdhury, M, De Bonis, A, Di Fresco, L, Scatigno, C, Parker, S, Fernandez-Alonso, F, Colognesi, D, Senesi, R, Andreani, C, Gorini, G, Scionti, G, and Schreyer, A

Subjects
powder diffractometer, materials science, guide, Accelerator-based neutron facilitie, Slow neutron scattering, 02 engineering and technology, spin dynamics, 7. Clean energy, 01 natural sciences, neutron-scattering, test beamline, [SPI]Engineering Sciences [physics], Conceptual design, Spallation, Pulsed neutron instrumentation, Instrumentation, ComputingMilieux_MISCELLANEOUS, lattice, Physics, Accelerator-based neutron facilities, ESS instrument suite, [PHYS]Physics [physics], Settore FIS/03, Suite, 021001 nanoscience & nanotechnology, ddc, accelerator-based neutron facilities, slow neutron scattering, 0210 nano-technology, Nuclear and High Energy Physics, ess instrument suite, F300, time-of-flight, antiferromagnetic order, 0103 physical sciences, Neutron, ddc:530, Aerospace engineering, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], 010306 general physics, Spectrometer, business.industry, pulsed neutron instrumentation, Neutron radiation, Beamline, Neutron source, spectrometer, business
Abstract

The MIRACLES team., An overview is provided of the 15 neutron beam instruments making up the initial instrument suite of the European Spallation Source (ESS), and being made available to the neutron user community. The ESS neutron source consists of a high-power accelerator and target station, providing a unique long-pulse time structure of slow neutrons. The design considerations behind the time structure, moderator geometry and instrument layout are presented. The 15-instrument suite consists of two small-angle instruments, two reflectometers, an imaging beamline, two single-crystal diffractometers; one for macromolecular crystallography and one for magnetism, two powder diffractometers, and an engineering diffractometer, as well as an array of five inelastic instruments comprising two chopper spectrometers, an inverse-geometry single-crystal excitations spectrometer, an instrument for vibrational spectroscopy and a high-resolution backscattering spectrometer. The conceptual design, performance and scientific drivers of each of these instruments are described. All of the instruments are designed to provide breakthrough new scientific capability, not currently available at existing facilities, building on the inherent strengths of the ESS long-pulse neutron source of high flux, flexible resolution and large bandwidth. Each of them is predicted to provide world-leading performance at an accelerator power of 2 MW. This technical capability translates into a very broad range of scientific capabilities. The composition of the instrument suite has been chosen to maximise the breadth and depth of the scientific impact of the early years of the ESS, and provide a solid base for completion and further expansion of the facility., Some of the work described here is part of projects that have received funding from the European Union’s Horizon 2020 research programme: SINE 2020 under grant agreement number 654000, BrightnESS under grant agreement number 676548, and SoNDe under grant agreement number 654124. Financial support for the fast-shutter upgrade for FREIA from Swedish Research Council VR, grant no 2018-05013, is acknowledged. The VESPA team gratefully acknowledges the Science & Technology Facilities Council (STFC) and the CNR , within the CNR-STFC Agreement (2014–2020) No. 3420.

32. Continue or stop reading? Modeling decisions in information search

Author

López-Orozco, F., Guérin-Dugué, A., Benoît Lemaire, Laboratoire de Psychologie et NeuroCognition (LPNC), Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), GIPSA - Vision and Brain Signal Processing (GIPSA-VIBS), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), and B. Sharp, M. Zock

Subjects
computational model, reading, [SCCO.PSYC]Cognitive science/Psychology, [SCCO.COMP]Cognitive science/Computer science, information search, decision making, text
Abstract

International audience; This paper presents a cognitive computational model of the way people read a paragraph with the task of quickly deciding whether it is better related to a given goal than another paragraph processed previously. In particular, the model attempts to predict the time at which participants would decide to stop reading the current paragraph because they have enough information to make their decision. We proposed a two-variable linear threshold to account for that decision, based on the rank of the fixation and the difference of semantic similarities between each paragraph and the goal. Our model performance is compared to the eye tracking data of 22 participants.

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