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2. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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D. KLIONSKY, A. ABDEL-AZIZ, S. ABDELFATAH, M. ABDELLATIF, A. ABDOLI, S. ABEL, H. ABELIOVICH, M. ABILDGAARD, Y. ABUDU, A. ACEVEDO-AROZENA, I. ADAMOPOULOS, K. ADELI, T. ADOLPH, A. ADORNETTO, E. AFLAKI, G. AGAM, A. AGARWAL, B. AGGARWAL, M. AGNELLO, P. AGOSTINIS, J. AGREWALA, A. AGROTIS, P. AGUILAR, S. AHMAD, Z. AHMED, U. AHUMADA-CASTRO, S. AITS, S. AIZAWA, Y. AKKOC, T. AKOUMIANAKI, H. AKPINAR, A. AL-ABD, L. AL-AKRA, A. AL-GHARAIBEH, M. ALAOUI-JAMALI, S. ALBERTI, E. ALCOCER-GOMEZ, C. ALESSANDRI, M. ALI, M. AL-BARI, S. ALIWAINI, J. ALIZADEH, E. ALMACELLAS, A. ALMASAN, A. ALONSO, G. ALONSO, N. ALTAN-BONNET, D. ALTIERI, S. ALVES, C. DA COSTA, M. ALZAHARNA, M. AMADIO, C. AMANTINI, C. AMARAL, S. AMBROSIO, A. AMER, V. AMMANATHAN, Z. AN, S. ANDERSEN, S. ANDRABI, M. ANDRADE-SILVA, A. ANDRES, S. ANGELINI, D. ANN, U. ANOZIE, M. ANSARI, P. ANTAS, A. ANTEBI, Z. ANTON, T. ANWAR, L. APETOH, N. APOSTOLOVA, T. ARAKI, Y. ARAKI, K. ARASAKI, W. ARAUJO, J. ARAYA, C. ARDEN, M. AREVALO, S. ARGUELLES, E. ARIAS, J. ARIKKATH, H. ARIMOTO, A. ARIOSA, D. ARMSTRONG-JAMES, L. ARNAUNE-PELLOQUIN, A. AROCA, D. ARROYO, I. ARSOV, R. ARTERO, D. ASARO, M. ASCHNER, M. ASHRAFIZADEH, O. ASHUR-FABIAN, A. ATANASOV, A. AU, P. AUBERGER, H. AUNER, L. AURELIAN, R. AUTELLI, L. AVAGLIANO, Y. AVALOS, S. AVEIC, C. AVELEIRA, T. AVINWITTENBERG, Y. AYDIN, S. AYTON, S. AYYADEVARA, M. AZZOPARDI, M. BABA, J. BACKER, S. BACKUES, D. BAE, O. BAE, S. BAE, E. BAEHRECKE, A. BAEK, S. BAEK, G. BAGETTA, A. BAGNIEWSKA-ZADWORNA, H. BAI, J. BAI, X. BAI, Y. BAI, N. BAIRAGI, S. BAKSI, T. BALBI, C. BALDARI, W. BALDUINI, A. BALLABIO, M. BALLESTER, S. BALAZADEH, R. BALZAN, R. BANDOPADHYAY, S. BANERJEE, Y. BAO, M. BAPTISTA, A. BARACCA, C. BARBATI, A. BARGIELA, D. BARILA, P. BARLOW, S. BARMADA, E. BARREIRO, G. BARRETO, J. BARTEK, B. BARTEL, A. BARTOLOME, G. BARVE, S. BASAGOUDANAVAR, D. BASSHAM, R. JR, A. BASU, H. BATOKO, I. BATTEN, E. BAULIEU, B. BAUMGARNER, J. BAYRY, R. BEALE, I. BEAU, F. BEAUMATIN, L. BECHARA, G. BECK, M. BEERS, J. BEGUN, C. BEHRENDS, G. BEHRENS, R. BEI, E. BEJARANO, S. BEL, C. BEHL, A. BELAID, N. BELGAREH-TOUZE, C. BELLAROSA, F. BELLEUDI, M. PEREZ, R. BELLO-MORALES, J. BELTRAN, S. BELTRAN, D. BENBROOK, M. BENDORIUS, B. BENITEZ, I. BENITO-CUESTA, J. BENSALEM, M. BERCHTOLD, S. BEREZOWSKA, D. BERGAMASCHI, M. BERGAMI, A. BERGMANN, L. BERLIOCCHI, C. BERLIOZ-TORRENT, A. BERNARD, L. BERTHOUX, C. BESIRLI, S. BESTEIRO, V. BETIN, R. BEYAERT, J. BEZBRADICA, K. BHASKAR, I. BHATIA-KISSOVA, R. BHATTACHARYA, S. BHATTACHARYA, S. BHATTACHARYYA, M. BHUIYAN, S. BHUTIA, L. BI, X. BI, T. BIDEN, K. BIJIAN, V. BILLES, N. BINART, C. BINCOLETTO, A. BIRGISDOTTIR, G. BJORKOY, G. BLANCO, A. BLAS-GARCIA, J. BLASIAK, R. BLOMGRAN, K. BLOMGREN, J. BLUM, E. BOADA-ROMERO, M. BOBAN, K. BOESZEBATTAGLIA, P. BOEUF, B. BOLAND, P. BOMONT, P. BONALDO, S. BONAM, L. BONFILI, J. BONIFACINO, B. BOONE, M. BOOTMAN, M. BORDI, C. BORNER, B. BORNHAUSER, G. BORTHAKUR, J. BOSCH, S. BOSE, L. BOTANA, J. BOTAS, C. BOULANGER, M. BOULTON, M. BOURDENX, B. BOURGEOIS, N. BOURKE, G. BOUSQUET, P. BOYA, P. BOZHKOV, L. BOZI, T. BOZKURT, D. BRACKNEY, C. BRANDTS, R. BRAUN, G. BRAUS, R. BRAVO-SAGUA, J. BRAVO-SAN PEDRO, P. BREST, M. BRINGER, A. BRIONES-HERRERA, V. BROADDUS, P. BRODERSEN, E. ALVAREZ, J. BRODSKY, S. BRODY, P. BRONSON, J. BRONSTEIN, C. BROWN, R. BROWN, P. BRUM, J. BRUMELL, N. BRUNETTI-PIERRI, D. BRUNO, R. BRYSON-RICHARDSON, C. BUCCI, C. BUCHRIESER, M. BUENO, L. BUITRAGO-MOLINA, S. BURASCHI, S. BUCH, J. BUCHAN, E. BUCKINGHAM, H. BUDAK, M. BUDINI, G. BULTYNCK, F. BURADA, J. BURGOYNE, M. BURON, V. BUSTOS, S. BUTTNER, E. BUTTURINI, A. BYRD, I. CABAS, S. CABRERA-BENITEZ, K. CADWELL, J. CAI, L. CAI, Q. CAI, M. CAIRO, J. CALBET, G. CALDWELL, K. CALDWELL, J. CALL, R. CALVANI, A. CALVO, M. BARRERA, N. CAMARA, J. CAMONIS, N. CAMOUGRAND, M. CAMPANELLA, E. CAMPBELL, F. CAMPBELL-VALOIS, S. CAMPELLO, I. CAMPESI, J. CAMPOS, O. CAMUZARD, J. CANCINO, D. DE ALMEIDA, L. CANESI, I. CANIGGIA, B. CANONICO, C. CANTI, B. CAO, M. CARAGLIA, B. CARAMES, E. CARCHMAN, E. CARDENAL-MUNOZ, C. CARDENAS, L. CARDENAS, S. CARDOSO, J. CAREW, G. CARLE, G. CARLETON, S. CARLONI, D. CARMONA-GUTIERREZ, L. CARNEIRO, O. CARNEVALI, J. CAROSI, S. CARRA, A. CARRIER, L. CARRIER, B. CARROLL, A. CARTER, A. CARVALHO, M. CASANOVA, C. CASAS, J. CASAS, C. CASSIOLI, E. CASTILLO, K. CASTILLO, S. CASTILLO-LLUVA, F. CASTOLDI, M. CASTORI, A. CASTRO, M. CASTRO-CALDAS, J. CASTRO-HERNANDEZ, S. CASTRO-OBREGON, S. CATZ, C. CAVADAS, F. CAVALIERE, G. CAVALLINI, M. CAVINATO, M. CAYUELA, P. RICA, V. CECARINI, F. CECCONI, M. CECHOWSKA-PASKO, S. CENCI, V. CEPERUELO-MALLAFRE, J. CERQUEIRA, J. CERUTTI, D. CERVIA, V. CETINTAS, S. CETRULLO, H. CHAE, A. CHAGIN, C. CHAI, G. CHAKRABARTI, O. CHAKRABARTI, T. CHAKRABORTY, M. CHAMI, G. CHAMILOS, D. CHAN, E. CHAN, H. CHAN, M. CHAN, Y. CHAN, P. CHANDRA, C. CHANG, H. CHANG, K. CHANG, J. CHAO, T. CHAPMAN, N. CHARLET-BERGUERAND, S. CHATTERJEE, S. CHAUBE, A. CHAUDHARY, S. CHAUHAN, E. CHAUM, F. CHECLER, M. CHEETHAM, C. CHEN, G. CHEN, J. CHEN, L. CHEN, M. CHEN, N. CHEN, Q. CHEN, R. CHEN, S. CHEN, W. CHEN, X. CHEN, Y. CHEN, Z. CHEN, H. CHENG, J. CHENG, S. CHENG, W. CHENG, X. CHENG, Y. CHENG, Z. CHENG, H. CHEONG, J. CHEONG, B. CHERNYAK, S. CHERRY, C. CHEUNG, K. CHEUNG, E. CHEVET, R. CHI, A. CHIANG, F. CHIARADONNA, R. CHIARELLI, M. CHIARIELLO, N. CHICA, S. CHIOCCA, M. CHIONG, S. CHIOU, A. CHIRAMEL, V. CHIURCHIU, D. CHO, S. CHOE, A. CHOI, M. CHOI, K. CHOUDHURY, N. CHOW, C. CHU, J. CHUA, H. CHUNG, K. CHUNG, S. CHUNG, Y. CHUNG, V. CIANFANELLI, I. CIECHOMSKA, M. CIFUENTES, L. CINQUE, S. CIRAK, M. CIRONE, M. CLAGUE, R. CLARKE, E. CLEMENTI, E. COCCIA, P. CODOGNO, E. COHEN, M. COHEN, T. COLASANTI, F. COLASUONNO, R. COLBERT, A. COLELL, N. COLL, M. COLLINS, M. COLOMBO, D. COLON-RAMOS, L. COMBARET, S. COMINCINI, M. COMINETTI, A. CONSIGLIO, A. CONTE, F. CONTI, V. CONTU, M. COOKSON, K. COOMBS, I. COPPENS, M. CORASANITI, D. CORKERY, N. CORDES, K. CORTESE, M. COSTA, S. COSTANTINO, P. COSTELLI, A. COTO-MONTES, P. CRACK, J. 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DESCOTEAUX, L. DEVIS, S. DEVKOTA, O. DEVUYST, G. DEWSON, M. DHARMASIVAM, R. DHIMAN, D. DI BERNARDO, M. DI CRISTINA, F. DI DOMENICO, P. DI FAZIO, A. DI FONZO, G. DI GUARDO, G. DI GUGLIELMO, L. DI LEO, C. DI MALTA, A. DI NARDO, M. DI RIENZO, F. DI SANO, G. DIALLINAS, J. DIAO, G. DIAZ-ARAYA, I. DIAZ-LAVIADA, J. DICKINSON, M. DIEDERICH, M. DIEUDE, I. DIKIC, S. DING, W. DING, L. DINI, M. DINIC, A. DINKOVA-KOSTOVA, M. DIONNE, J. DISTLER, A. DIWAN, I. DIXON, M. DJAVAHERI-MERGNY, I. DOBRINSKI, O. DOBROVINSKAYA, R. DOBROWOLSKI, R. DOBSON, S. EMRE, M. DONADELLI, B. DONG, X. DONG, Z. DONG, G. II, V. DOTSCH, H. DOU, J. DOU, M. DOWAIDAR, S. DRIDI, L. DRUCKER, A. DU, C. DU, G. DU, H. DU, L. DU, A. DU TOIT, S. DUAN, X. DUAN, S. DUARTE, A. DUBROVSKA, E. DUNLOP, N. DUPONT, R. DURAN, B. DWARAKANATH, S. DYSHLOVOY, D. EBRAHIMI-FAKHARI, L. ECKHART, C. EDELSTEIN, T. EFFERTH, E. EFTEKHARPOUR, L. EICHINGER, N. EID, T. EISENBERG, N. EISSA, S. EISSA, M. EJARQUE, A. EL ANDALOUSSI, N. EL-HAGE, S. EL-NAGGAR, A. 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FRANCO, R. FRANCO, F. FRANCONI, L. FRANKEL, S. FRIEDMAN, L. FROHLICH, G. FRUHBECK, J. FUENTES, Y. FUJIKI, N. FUJITA, Y. FUJIWARA, M. FUKUDA, S. FULDA, L. FURIC, N. FURUYA, C. FUSCO, M. GACK, L. GAFFKE, S. GALADARI, A. GALASSO, M. GALINDO, S. KANKANAMALAGE, L. GALLUZZI, V. GALY, N. GAMMOH, B. GAN, I. GANLEY, F. GAO, H. GAO, M. GAO, P. GAO, S. GAO, W. GAO, X. GAO, A. GARCERA, M. GARCIA, V. GARCIA, F. GARCIA-DEL PORTILLO, V. GARCIA-ESCUDERO, A. GARCIAGARCIA, M. GARCIA-MACIA, D. GARCIA-MORENO, C. GARCIA-RUIZ, P. GARCIA-SANZ, A. GARG, R. GARGINI, T. GAROFALO, R. GARRY, N. GASSEN, D. GATICA, L. GE, W. GE, R. GEISS-FRIEDLANDER, C. GELFI, P. GENSCHIK, I. GENTLE, V. GERBINO, C. GERHARDT, K. GERMAIN, M. GERMAIN, D. GEWIRTZ, E. AFSHAR, S. GHAVAMI, A. GHIGO, M. GHOSH, G. GIAMAS, C. GIAMPIETRI, A. GIATROMANOLAKI, G. GIBSON, S. GIBSON, V. GINET, E. GINIGER, C. GIORGI, H. GIRAO, S. GIRARDIN, M. GIRIDHARAN, S. GIULIANO, C. GIULIVI, S. GIURIATO, J. GIUSTINIANI, A. GLUSCHKO, V. GODER, A. GOGINASHVILI, J. GOLAB, D. GOLDSTONE, A. GOLEBIEWSKA, L. GOMES, R. GOMEZ, R. GOMEZ-SANCHEZ, M. GOMEZ-PUERTO, R. GOMEZ-SINTES, Q. GONG, F. GONI, J. GONZALEZ-GALLEGO, T. GONZALEZ-HERNANDEZ, R. GONZALEZ-POLO, J. GONZALEZ-REYES, P. GONZALEZ-RODRIGUEZ, I. GOPING, M. GORBATYUK, N. GORBUNOV, R. GOROJOD, S. GORSKI, S. GORUPPI, C. GOTOR, R. GOTTLIEB, I. GOZES, D. GOZUACIK, M. GRAEF, M. GRALER, V. GRANATIERO, D. GRASSO, J. GRAY, D. GREEN, A. GREENHOUGH, S. GREGORY, E. GRIFFIN, M. GRINSTAFF, F. GROS, C. GROSE, A. GROSS, F. GRUBER, P. GRUMATI, T. GRUNE, X. GU, J. GUAN, C. GUARDIA, K. GUDA, F. GUERRA, C. GUERRI, P. GUHA, C. GUILLEN, S. GUJAR, A. GUKOVSKAYA, I. GUKOVSKY, J. GUNST, A. GUNTHER, A. GUNTUR, C. GUO, H. GUO, L. GUO, M. GUO, P. GUPTA, A. FERNANDEZ, S. GUPTA, V. GUPTA, A. GUSTAFSSON, D. GUTTERMAN, H. RANJITHA, A. HAAPASALO, J. HABER, S. HADANO, A. HAFREN, M. HAIDAR, B. HALL, G. HALLDEN, A. HAMACHER-BRADY, A. HAMANN, M. HAMASAKI, W. HAN, M. HANSEN, P. HANSON, Z. HAO, M. HARADA, L. 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SAFTIG, A. SAGONA, G. SAHAY, A. SAHEBKAR, M. SAHIN, O. SAHIN, S. SAHNI, N. SAITO, S. SAITO, T. SAITO, R. SAKAI, Y. SAKAI, J. SAKAMAKI, K. SAKSELA, G. SALAZAR, A. SALAZAR-DEGRACIA, G. SALEKDEH, A. SALUJA, B. SAMPAIO-MARQUES, M. SANCHEZ, J. SANCHEZ-ALCAZAR, V. SANCHEZ-VERA, V. SANCHO-SHIMIZU, J. SANDERSON, M. SANDRI, S. SANTAGUIDA, L. SANTAMBROGIO, M. SANTANA, G. SANTONI, A. SANZ, P. SANZ, S. SARAN, M. SARDIELLO, T. SARGEANT, A. SARIN, C. SARKAR, S. SARKAR, M. SARRIAS, D. SARMAH, J. SARPARANTA, A. SATHYANARAYAN, R. SATHYANARAYANAN, K. SCAGLIONE, F. SCATOZZA, L. SCHAEFER, Z. SCHAFER, U. SCHAIBLE, A. SCHAPIRA, M. SCHARL, H. SCHATZL, C. SCHEIN, W. SCHEPER, D. SCHEURING, M. SCHIAFFINO, M. SCHIAPPACASSI, R. SCHINDL, U. SCHLATTNER, O. SCHMIDT, R. SCHMITT, S. SCHMIDT, I. SCHMITZ, E. SCHMUKLER, A. SCHNEIDER, B. SCHNEIDER, R. SCHOBER, A. SCHOIJET, M. SCHOTT, M. SCHRAMM, B. SCHRODER, K. SCHUH, C. SCHULLER, R. SCHULZE, L. SCHURMANNS, J. SCHWAMBORN, M. SCHWARTEN, F. SCIALO, S. SCIARRETTA, M. SCOTT, K. SCOTTO, A. SCOVASSI, A. SCRIMA, A. SCRIVO, D. SEBASTIAN, S. SEBTI, S. SEDEJ, L. SEGATORI, N. SEGEV, P. SEGLEN, I. SEILIEZ, E. SEKI, S. SELLECK, F. SELLKE, A. PEREZ-LARA, J. SELSBY, M. SENDTNER, S. SENTURK, E. SERANOVA, C. SERGI, R. SERRA-MORENO, H. SESAKI, C. SETTEMBRE, S. SETTY, G. SGARBI, O. SHA, J. SHACKA, J. SHAH, D. SHANG, C. SHAO, F. SHAO, S. SHARBATI, L. SHARKEY, D. SHARMA, G. SHARMA, K. SHARMA, P. SHARMA, S. SHARMA, H. SHEN, J. SHEN, M. SHEN, W. SHEN, Z. SHEN, R. SHENG, Z. SHENG, J. SHI, X. SHI, Y. SHI, K. SHIBA-FUKUSHIMA, J. SHIEH, Y. SHIMADA, S. SHIMIZU, M. SHIMOZAWA, T. SHINTANI, C. SHOEMAKER, S. SHOJAEI, I. SHOJI, B. SHRAVAGE, V. SHRIDHAR, C. SHU, H. SHU, K. SHUI, A. SHUKLA, T. SHUTT, V. SICA, A. SIDDIQUI, A. SIERRA, V. SIERRA-TORRE, S. SIGNORELLI, P. SIL, B. SILVA, J. SILVA, E. SILVA-PAVEZ, S. SILVENTE-POIROT, R. SIMMONDS, A. SIMON, H. SIMON, M. SIMONS, A. SINGH, L. SINGH, R. SINGH, S. SINGH, D. SINHA, R. SINHA, S. SINHA, A. SIRKO, K. SIROHI, E. SIVRIDIS, P. SKENDROS, A. SKIRYCZ, I. SLANINOVA, S. SMAILI, A. SMERTENKO, M. SMITH, S. SOENEN, E. SOHN, S. SOK, G. SOLAINI, T. SOLDATI, S. SOLEIMANPOUR, R. SOLER, A. SOLOVCHENKO, J. SOMARELLI, A. SONAWANE, F. SONG, H. SONG, J. SONG, K. SONG, Z. SONG, L. SORIA, M. SORICE, A. SOUKAS, S. SOUKUP, D. SOUSA, N. SOUSA, P. SPAGNUOLO, S. SPECTOR, M. BHARATH, D. ST CLAIR, V. STAGNI, L. STAIANO, C. STALNECKER, M. STANKOV, P. STATHOPULOS, K. STEFAN, S. STEFAN, L. STEFANIS, J. STEFFAN, A. STEINKASSERER, H. STENMARK, J. STERNECKERT, C. STEVENS, V. STOKA, S. STORCH, B. STORK, F. STRAPPAZZON, A. STROHECKER, D. STUPACK, H. SU, L. SU, A. SUAREZFONTES, C. SUBAUSTE, S. SUBBIAN, P. SUBIRADA, G. SUDHANDIRAN, C. SUE, X. SUI, C. SUMMERS, G. SUN, J. SUN, K. SUN, M. SUN, Q. SUN, Y. SUN, Z. SUN, K. SUNAHARA, E. SUNDBERG, K. SUSZTAK, P. SUTOVSKY, H. SUZUKI, G. SWEENEY, J. SYMONS, S. SZE, N. SZEWCZYK, C. TABOLACCI, F. TACKE, H. TAEGTMEYER, M. TAFANI, M. TAGAYA, H. TAI, S. TAIT, Y. TAKAHASHI, S. TAKATS, P. TALWAR, C. TAM, S. TAM, D. TAMPELLINI, A. TAMURA, C. TAN, E. TAN, Y. TAN, M. TANAKA, D. TANG, J. TANG, T. TANG, I. TANIDA, Z. TAO, M. TAOUIS, L. TATENHORST, N. TAVERNARAKIS, A. TAYLOR, G. TAYLOR, J. TAYLOR, E. TCHETINA, A. TEE, I. TEGEDER, D. TEIS, N. TEIXEIRA, F. TEIXEIRA-CLERC, K. TEKIRDAG, T. TENCOMNAO, S. TENREIRO, A. TEPIKIN, P. TESTILLANO, G. TETTAMANTI, P. THARAUX, K. THEDIECK, A. THEKKINGHAT, S. THELLUNG, J. THINWA, V. THIRUMALAIKUMAR, S. THOMAS, P. THOMES, A. THORBURN, L. THUKRAL, T. THUM, M. THUMM, L. TIAN, A. TICHY, A. TILL, V. TIMMERMAN, V. TITORENKO, S. TODI, K. TODOROVA, J. TOIVONEN, L. TOMAIPITINCA, D. TOMAR, C. TOMAS-ZAPICO, B. TONG, C. TONG, X. TONG, S. TOOZE, M. TORGERSEN, S. TORII, L. TORRES-LOPEZ, A. TORRIGLIA, C. TOWERS, R. TOWNS, S. TOYOKUNI, V. TRAJKOVIC, D. TRAMONTANO, Q. TRAN, L. TRAVASSOS, C. TRELFORD, S. TREMEL, I. TROUGAKOS, B. TSAO, M. TSCHAN, H. TSE, T. TSE, H. TSUGAWA, A. TSVETKOV, D. TUMBARELLO, Y. TUMTAS, M. TUNON, S. TURCOTTE, B. TURK, V. TURK, B. TURNER, R. TUXWORTH, J. TYLER, E. TYUTEREVA, Y. UCHIYAMA, A. UGUNKLUSEK, H. UHLIG, I. ULASOV, M. UMEKAWA, C. UNGERMANN, R. UNNO, S. URBE, E. URIBE-CARRETERO, S. USTUN, V. UVERSKY, T. VACCARI, M. VACCARO, B. VAHSEN, H. VAKIFAHMETOGLU-NORBERG, R. VALDOR, M. VALENTE, A. VALKO, R. VALLEE, A. VALVERDE, G. VAN DEN BERGHE, S. VAN DER VEEN, L. VAN KAER, J. VAN LOOSDREGT, S. VAN WIJK, W. VANDENBERGHE, I. VANHOREBEEK, M. VANNIER-SANTOS, N. VANNINI, M. VANRELL, C. VANTAGGIATO, G. VARANO, I. VARELA-NIETO, M. VARGA, M. VASCONCELOS, S. VATS, D. VAVVAS, I. VEGANAREDO, S. VEGA-RUBIN-DE-CELIS, G. VELASCO, A. VELAZQUEZ, T. VELLAI, E. VELLENGA, F. VELOTTI, M. VERDIER, P. VERGINIS, I. VERGNE, P. VERKADE, M. VERMA, P. VERSTREKEN, T. VERVLIET, J. VERVOORTS, A. VESSONI, V. VICTOR, M. VIDAL, C. VIDONI, O. VIEIRA, R. VIERSTRA, S. VIGANO, H. VIHINEN, V. VIJAYAN, M. VILA, M. VILAR, J. VILLALBA, A. VILLALOBO, B. VILLAREJO-ZORI, F. VILLARROYA, J. VILLARROYA, O. VINCENT, C. VINDIS, C. VIRET, M. VISCOMI, D. VISNJIC, I. VITALE, D. VOCADLO, O. VOITSEKHOVSKAJA, C. VOLONTE, M. VOLTA, M. VOMERO, C. VON HAEFEN, M. VOOIJS, W. VOOS, L. VUCICEVIC, R. WADE-MARTINS, S. WAGURI, K. WAITE, S. WAKATSUKI, D. WALKER, M. WALKER, S. WALKER, J. WALTER, F. WANDOSELL, B. WANG, C. WANG, D. WANG, F. WANG, G. WANG, H. WANG, J. WANG, K. WANG, L. WANG, M. WANG, N. WANG, P. WANG, Q. WANG, W. WANG, X. WANG, Y. WANG, Z. WANG, G. WARNES, V. WARNSMANN, H. WATADA, E. WATANABE, M. WATCHON, T. WEAVER, G. WEGRZYN, A. WEHMAN, H. WEI, L. WEI, T. WEI, Y. WEI, O. WEIERGRABER, C. WEIHL, G. WEINDL, R. WEISKIRCHEN, A. WELLS, R. WEN, X. WEN, A. WERNER, B. WEYKOPF, S. WHEATLEY, J. WHITTON, A. WHITWORTH, K. WIKTORSKA, M. WILDENBERG, T. WILEMAN, S. WILKINSON, D. WILLBOLD, B. WILLIAMS, R. WILLIAMS, P. WILLIAMSON, R. WILSON, B. WINNER, N. WINSOR, S. WITKIN, H. WODRICH, U. WOEHLBIER, T. WOLLERT, E. WONG, J. WONG, R. WONG, V. WONG, W. WONG, A. WU, C. WU, J. WU, K. WU, M. WU, S. WU, W. WU, X. WU, Y. WU, R. XAVIER, H. XIA, L. XIA, Z. XIA, G. XIANG, J. XIANG, M. XIANG, W. XIANG, B. XIAO, G. XIAO, H. XIAO, J. XIAO, L. XIAO, S. XIAO, Y. XIAO, B. XIE, C. XIE, M. XIE, Y. XIE, Z. XIE, M. XILOURI, C. XU, E. XU, H. XU, J. XU, L. XU, W. XU, X. XU, Y. XUE, S. YAKHINE-DIOP, M. YAMAGUCHI, O. YAMAGUCHI, A. YAMAMOTO, S. YAMASHINA, S. YAN, Z. YAN, Y. YANAGI, C. YANG, D. YANG, H. YANG, J. YANG, L. YANG, M. YANG, P. YANG, Q. YANG, S. YANG, W. YANG, X. YANG, Y. YANG, H. YAO, S. YAO, X. YAO, Y. YAO, T. YASUI, M. YAZDANKHAH, P. YEN, C. YI, X. YIN, Y. YIN, Z. YIN, M. YING, Z. YING, C. YIP, S. YIU, Y. YOO, K. YOSHIDA, S. YOSHII, T. YOSHIMORI, B. YOUSEFI, B. YU, H. YU, J. YU, L. YU, M. YU, S. YU, V. YU, W. YU, Z. YU, J. YUAN, L. YUAN, S. YUAN, Y. YUAN, Z. YUAN, J. YUE, Z. YUE, J. YUN, R. YUNG, D. ZACKS, G. ZAFFAGNINI, V. ZAMBELLI, I. ZANELLA, Q. ZANG, S. ZANIVAN, S. ZAPPAVIGNA, P. ZARAGOZA, K. ZARBALIS, A. ZAREBKOHAN, A. ZARROUK, S. ZEITLIN, J. ZENG, E. ZEROVNIK, L. ZHAN, B. ZHANG, D. ZHANG, H. ZHANG, J. ZHANG, K. ZHANG, L. ZHANG, M. ZHANG, P. ZHANG, S. ZHANG, W. ZHANG, X. ZHANG, Y. ZHANG, Z. ZHANG, H. ZHAO, L. ZHAO, S. ZHAO, T. ZHAO, X. ZHAO, Y. ZHAO, G. ZHENG, K. ZHENG, L. ZHENG, S. ZHENG, X. ZHENG, Y. ZHENG, Z. ZHENG, B. ZHIVOTOVSKY, Q. ZHONG, A. ZHOU, B. ZHOU, C. ZHOU, G. ZHOU, H. ZHOU, J. ZHOU, K. ZHOU, R. ZHOU, X. ZHOU, Y. ZHOU, Z. ZHOU, B. ZHU, C. ZHU, G. ZHU, H. ZHU, W. ZHU, Y. ZHU, H. ZHUANG, X. ZHUANG, K. ZIENTARA-RYTTER, C. ZIMMERMANN, E. ZIVIANI, T. ZOLADEK, W. ZONG, D. ZOROV, A. ZORZANO, W. ZOU, Z. ZOU, S. ZURYN, W. ZWERSCHKE, B. BRAND-SABERI, C. KENCHAPPA, S. OSHIMA, Y. RONG, J. SLUIMER, and C. STALLINGS
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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
3. Nerve problems of the foot and ankle: evaluation, diagnosis, and treatment
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Richard M. Marks and Gregory S. Finkbeiner
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medicine.medical_specialty ,medicine.anatomical_structure ,Physical medicine and rehabilitation ,business.industry ,medicine ,Surgery ,Ankle ,Neuroma ,medicine.disease ,business ,Foot (unit) - Abstract
This review will focus on nerve problems of the foot and ankle. Entrapment syndromes along with interdigital (Morton's) neuroma comprise most of these problems. The first step in the management of these disorders is making the correct diagnosis. Knowledge of the anatomy, a thorough history and physi
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- 2002
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4. Structure and optical properties of the planar silicon compounds polysilane and Wöhler siloxene
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Wolfgang Hönle, A. Molassioti-Dohms, S. Finkbeiner, Ursula Dettlaff-Weglikowska, and J. Weber
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Excitation spectroscopy ,Crystallography ,chemistry.chemical_compound ,Photoluminescence ,Materials science ,Planar ,chemistry ,Silicon ,Infrared transmission ,Structure (category theory) ,Polysilane ,chemistry.chemical_element ,Crystal structure - Abstract
The two-dimensional silicon backbone structure of planar polysilane and W\"ohler siloxene is responsible for their exciting luminescing properties. We have prepared single crystals of siloxene by a topotactic reaction from crystalline CaSi${}_{2}$. The chemical composition was determined as [Si${}_{6}$H${}_{3}$(OH)${}_{3}$]${}_{n}.$ The x-ray crystal structure analysis identifies the so-called W\"ohler siloxene as 2D-poly[1,3,5-trihydroxocyclohexasilane]. Polysilane exhibits the same structural properties but with a chemical composition [Si${}_{6}$H${}_{6}$]${}_{n}.$ The optical properties (infrared transmission, photoluminescence, excitation spectroscopy) of these well-defined materials are presented. A heat treatment above $350\ifmmode^\circ\else\textdegree\fi{}$C in vacuum of W\"ohler siloxene results in a destruction of the planar ${}_{\ensuremath{\infty}}^{2}$ [Si${}^{\ensuremath{-}}$] structure by internal rearrangements, which is evidenced by the x-ray-diffraction pattern and characteristic changes in the optical spectra. The involvement of W\"ohler siloxene in the optical properties of porous Si is critically reviewed.
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- 1997
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5. Photo‐ and Chemiluminescence from Wöhler Siloxenes
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J. Weber, Wolfgang Hönle, Ursula Dettlaff-Weglikowska, S. Finkbeiner, and A. Molassioti-Dohms
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Photoluminescence ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Cyclohexane conformation ,Condensed Matter Physics ,Ring (chemistry) ,Porous silicon ,Photochemistry ,Block (periodic table) ,Spectral line ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,law ,Materials Chemistry ,Electrochemistry ,Chemiluminescence - Abstract
The photo‐ and chemiluminescence of Wohler siloxenes, , in the two oxidation stages with x = 0: yellow siloxene and x = 1: red siloxene were studied. During slow oxidation both compounds exhibit a shift of the photoluminescence spectra at room temperature, but the position of the chemiluminescence is not affected. Our results support the buckled‐layer structure of Wohler siloxenes with the ‐ring in chair conformation as the building block. The Si‒H bonds on the ring can be successively oxidized (0 ≤ x ≤ 3), leading to a shift in the photoluminescence spectrum. Total oxidation of all three Si‒H bonds results in an unstable modification, which transforms rapidly to a new substance with distinctively different optical properties. The results on siloxene have common features with measurements on porous silicon. However, the quantitative differences in the spectra indicate that in porous silicon, the emission properties are not directly associated with Wohler siloxenes.
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- 1996
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6. Carrier mobilities in graded InxGa1−xAs/Al0.2Ga0.8As quantum wells for high electron mobility transistors
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Henning Riechert, D. Bernklau, U. Strauß, and S. Finkbeiner
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Condensed Matter::Materials Science ,Electron density ,Electron mobility ,Condensed matter physics ,Chemistry ,Doping ,Induced high electron mobility transistor ,General Physics and Astronomy ,Electron ,Electronic band structure ,Quantum well ,Molecular beam epitaxy - Abstract
We investigate modulation‐doped InxGa1−xAs/AlyGa1−yAs quantum wells grown by molecular beam epitaxy with respect to carrier mobility and its dependence on In content, In distribution, populations of electron subbands, and local positions of electron wave functions. We find that the room‐temperature electron mobilities are dominated by the In contents at the maxima of the electron wave functions rather than by the average In contents. At 77 K the mobilities are most strongly influenced by the distance between doping layers and the maxima of the electron wave functions. As a practical result of this study, we present a quantum well structure for high electron mobility transistors with a carrier mobility as high as 8100 cm2/V s at 295 K for an electron density of 2.5×1012 cm−2.
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- 1996
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7. Temperature dependence of the indirect energy gap in crystalline silicon
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J. Weber, V. Alex, and S. Finkbeiner
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Photoluminescence ,Materials science ,Condensed matter physics ,Silicon ,Band gap ,Exciton ,General Physics and Astronomy ,chemistry.chemical_element ,Spectral line ,chemistry ,Direct and indirect band gaps ,Crystalline silicon ,Atomic physics ,Line (formation) - Abstract
The photoluminescence spectra of crystalline silicon samples are measured for temperatures below 1000 K. The optical transitions are analyzed in terms of excitonic and band‐to‐band transitions. From the modeling of the line shape we are able to determine the fundamental indirect band gap for temperatures up to 750 K. The temperature dependence follows the Varshni equation with Eg(0)=1.1692 eV, α=(4.9±0.2)×10−4 eV/K and β=(655±40) K.
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- 1996
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8. Resonantly excited photoluminescence spectra of porous silicon
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M. Rosenbauer, J. Weber, Martin Stutzmann, S. Finkbeiner, and E. Bustarret
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Photoluminescence ,Materials science ,Excited state ,Porous silicon ,Molecular physics ,Spectral line - Published
- 1995
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9. Interpretation of the temperature dependence of the strong visible photoluminescence of porous silicon
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S. Finkbeiner and J. Weber
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Photoluminescence ,Silicon ,Condensed Matter::Other ,Chemistry ,Exciton ,Metals and Alloys ,Analytical chemistry ,chemistry.chemical_element ,Surfaces and Interfaces ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,Porous silicon ,Molecular physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Condensed Matter::Materials Science ,Materials Chemistry ,Photoluminescence excitation ,Singlet state ,Spectroscopy ,Luminescence - Abstract
The temperature dependence of the strong visible photoluminescence (550–850 nm) is studied in differently prepared porous silicon samples. The variation in the photoluminescence intensity with temperature is a result of a decrease in the radiative decay time and an increase in the non-radiative recombination process with increasing temperatures. The strong visible photoluminescence is interpreted by a recombination of singlet and triplet excitons. The singlet-triplet splitting is comparable for all samples but depends on the detection wavelength and on sample preparation. We present similar data for the recombination process in siloxene which supports the model of a common origin of the strong visible photoluminescence in these very differently prepared samples.
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- 1995
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10. Resonantly excited photoluminescence in porous silicon
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D.H. Leach, M. Rosenbauer, Martin Stutzmann, M. Sendova-Vassileva, and S. Finkbeiner
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Materials science ,Photoluminescence ,Silicon ,Phonon ,business.industry ,Metals and Alloys ,chemistry.chemical_element ,Surfaces and Interfaces ,Laser ,Porous silicon ,Molecular physics ,Spectral line ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,Optics ,chemistry ,law ,Excited state ,Materials Chemistry ,Luminescence ,business - Abstract
We report on the photoluminescence (PL) spectra of porous silicon excited resonantly by laser lines within the luminescence band. Measurements have been performed for different excitation energies, temperatures and delay times. At low temperatures, the known step-like phonon structure in the PL spectra of porous silicon and a gap of the few millielectronvolts between the laser line and the onset of the luminescence are observed. As the temperature is increased, the onsets of both the PL spectra and the step features shift towards higher energies whereas the peak of the spectrum moves towards lower energies by an amount which depends on the delay time after excitation. Furthermore, the gap disappears and simultaneously an exponential tail of the spectrum occurs on the high energy side of the laser line, which broadens proportionally to kT . These results are discussed in light of the existing theories for the luminescence mechanism in porous silicon and for the origin of the step features in the PL spectra.
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- 1995
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11. Generalized Planck's radiation law for luminescence via indirect transitions
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P. Würfel, E. Daub, and S. Finkbeiner
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Photon ,Planck's law ,Thermal radiation ,Chemistry ,Law ,General Materials Science ,Direct and indirect band gaps ,General Chemistry ,Emission spectrum ,Photon energy ,Atomic physics ,Absorption (electromagnetic radiation) ,Ground state - Abstract
Based on microscopic transition probabilities and on the principle of detailed balance, absorption and emission rates are calculated for indirect transitions. It is found that the emission rate at a photon energy ħω can be expressed by the absorption coefficient for the same photon energy in the same way as for direct transitions. This relation is quite generally valid including cases where the electrons in the exited state (conduction band) and the electrons in the ground state (valence band) are distributed according to two different quasi-Fermi distributions. A generalized Planck's law is formulated for luminescence which contains a nonzero chemical potential of the emitted photons as the only difference to the description of thermal radiation.
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- 1995
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12. Luminescence and optical properties of siloxene
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M. Rosenbauer, J. Weber, Martin Stutzmann, Martin S. Brandt, H. D. Fuchs, Peter Deák, and S. Finkbeiner
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business.industry ,Chemistry ,Biophysics ,General Chemistry ,Condensed Matter Physics ,Porous silicon ,Biochemistry ,Atomic and Molecular Physics, and Optics ,Visible energy ,Optics ,Quantum dot ,Radiative transfer ,Optoelectronics ,Direct and indirect band gaps ,Spontaneous emission ,business ,Luminescence ,Porosity - Abstract
We review the optical and luminescence properties of siloxene (Si 6 O 3 H 6 ). The preparation and basic structural properties of siloxene are described, and theoretical results concerning optical transitions in different modifications of siloxene are discussed. The dominant structural building blocks in as-prepared siloxene are two-dimensional Si planes which gave rise to a direct band gap in the visible energy range. The optical properties of annealed siloxene originate from isolated Si 6 rings which act as radiative recombination centers. The luminescence of annealed siloxene and porous silicon are compared in detail. In particular, new experimental results based on optically detected magnetic resonance provide microscopic information about radiative states in porous Si which is incompatible with the conventional quantum confinement model.
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- 1993
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13. Temperature dependence of luminescence in porous silicon and related materials
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M. Rosenbauer, J. Weber, H. D. Fuchs, Martin Stutzmann, and S. Finkbeiner
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Photoluminescence ,Silicon ,Annealing (metallurgy) ,Chemistry ,Biophysics ,Analytical chemistry ,chemistry.chemical_element ,General Chemistry ,Condensed Matter Physics ,Porous silicon ,Biochemistry ,Atomic and Molecular Physics, and Optics ,Amorphous solid ,Luminescence ,Porous medium ,Excitation - Abstract
We have investigated the temperature dependence of the visible luminescence of porous silicon and other Si-based luminescent materials (as-prepared and annealed siloxene, amorphous Si:O:H alloys) at temperatures between 10 and 359 K. In all samples, the decrease of the luminescence intensity, I(T), at temperatures > 100 K can be described by the relation I0/I(T) = 1 + exp(T/T0). At temperatures < 100 K, some of the strongly luminescent samples show a decrease of the luminescence intensity with decreasing temperature. We have found this decrease to be related to a “fine structure” in the luminescence spectra of yet unknown origin.
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- 1993
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14. Transient photoluminescence decay in porous silicon and siloxene
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Martin Stutzmann, M. Rosenbauer, J. Weber, and S. Finkbeiner
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Photoluminescence ,Chemistry ,Biophysics ,Analytical chemistry ,Physics::Optics ,Pulse duration ,General Chemistry ,Condensed Matter Physics ,Porous silicon ,Laser ,Biochemistry ,Molecular physics ,Atomic and Molecular Physics, and Optics ,law.invention ,Wavelength ,law ,High Energy Physics::Experiment ,Exponential decay ,Luminescence ,Excitation - Abstract
The photoluminescence decay after laser pulse excitation is studied in porous silicon and siloxene as a function of sample temperature, detection wavelength, laser intensity, and pulse length. The time dependence in all samples is characterized by a nonexponential decay directly after the laser excitation and a single exponential decay for long times after the laser pulse. The exponential decay is identical for the porous silicon samples and annealed siloxene and depends only on detection wavelength and sample temperature. As prepared siloxene exhibits the same decay characteristics. However, the nonexponential decay is more pronounced and the single exponential decay is a factor of 2–5 faster compared with annealed siloxene. The decay of the photoluminescence is another indication of the identical origin of the strong visible luminescence in porous Si and in annealed siloxene.
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- 1993
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15. THEORETICAL AND EXPERIMENTAL STUDIES ON SILOXENE
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Martin Stutzmann, M. Rosenbauer, J. Weber, Martin S. Brandt, S. Finkbeiner, P. Deák, and H. D. Fuchs
- Subjects
Quantum chemical ,Diffraction ,Materials science ,Nuclear magnetic resonance ,Annealing (metallurgy) ,Infrared spectroscopy ,Statistical and Nonlinear Physics ,Condensed Matter Physics ,Luminescence ,Molecular physics ,Excitation ,Stoichiometry ,Electronic properties - Abstract
Structural and optical properties of siloxene ( Si 6 O 3 H 6) and its derivatives obtained by chemical substitution or annealing are reviewed. The preparation of siloxene is briefly described and results of x-ray diffraction and infrared absorption are shown. The equilibrium structures of stoichiometric siloxene and the electronic properties of the corresponding 2, 1, and 0-dimensional Si-clusters are obtained from quantum chemical calculations and compared to other calculations. Experimental results concerning luminescence, luminescence excitation, absorption coefficients, magnetic resonance, and stability are presented. The origin of the optical properties of siloxene is discussed based on the accumulated experimental data and on the results of theoretical modeling.
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- 1993
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16. Verification of a generalized Planck law for luminescence radiation from silicon solar cells
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K. Schick, E. Daub, S. Finkbeiner, and P. Würfel
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Physics ,Physics and Astronomy (miscellaneous) ,business.industry ,General Engineering ,Detailed balance ,General Chemistry ,Radiation ,Computational physics ,law.invention ,symbols.namesake ,Optics ,Planck's law ,law ,Solar cell ,symbols ,General Materials Science ,Planck ,Absorption (electromagnetic radiation) ,Luminescence ,business ,Kirchhoff's law of thermal radiation - Abstract
A generalization of Planck's radiation law based on the principle of detailed balance predicts the emission of luminescence radiation from absorption data for direct transitions in semiconductors. Its validity for indirect transitions is questionable due to the participation of phonons. We have tested the validity for the indirect transitions in Si by measuring absolute values of the emission intensity from Si solar cells under forward bias at room temperature and find good agreement with theoretical predictions based on existing absorption data. The generalized Planck law, thus verified for the indirect transitions in Si, allows to determine the performance of solar cell materials from measuring the absolute intensity of their emission of luminescence radiation when irradiated by the sun.
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- 1992
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17. Sending signals from the synapse to the nucleus: possible roles for CaMK, Ras/ERK, and SAPK pathways in the regulation of synaptic plasticity and neuronal growth
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J, Curtis and S, Finkbeiner
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Cell Nucleus ,Neurons ,Neuronal Plasticity ,Models, Chemical ,Synapses ,ras Proteins ,Animals ,Humans ,Mitogen-Activated Protein Kinases ,Protein Kinases ,Signal Transduction - Abstract
The ability to learn and form memories depends on specific patterns of synaptic activity and is in part transcription dependent. However, the signal transduction pathways that connect signals generated at synapses with transcriptional responses in the nucleus are not well understood. In the present report, we discuss three signal transduction pathways: the Ca(2+)/calmodulin-dependent kinase (CaMK) pathway, the Ras/ERK pathway, and the SAPK pathways that might function to couple synaptic activity to long-term adaptive responses, in part through the regulation of new gene expression. Evidence suggests that these pathways become activated in response to stimuli that regulate synaptic function such as the influx of extracellular Ca(2+) and certain neurotrophin growth factors such as brain-derived neurotrophic factor. Once activated, the CaMK, Ras/ERK, and SAPK pathways lead to the phosphorylation and activation of transcription factors in the nucleus such as the cyclic AMP response element binding protein (CREB). Genes regulated by CREB or other transcription factor targets of the CaMK, Ras/ERK, and SAPK pathways could mediate important adaptive responses to changes in synaptic activity such as changes in synaptic strength and the regulation of neuronal survival and death.
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- 1999
18. Ca2+ channel-regulated neuronal gene expression
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S, Finkbeiner and M E, Greenberg
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DNA-Binding Proteins ,Neurons ,Serum Response Factor ,Base Sequence ,Gene Expression Regulation ,Protein Biosynthesis ,Cyclic AMP ,Animals ,Nuclear Proteins ,Calcium Channels ,Calcium Signaling ,Cyclic AMP Response Element-Binding Protein ,Response Elements - Abstract
Neuronal activity is required for the survival of specific populations of neurons, for the proper synaptic organization of the visual and somatosensory cortex, and for learning and memory. The biochemical mechanisms that couple brief neuronal activity to rapid and lasting adaptive changes within the nervous system are poorly understood. Over a decade ago, it was first shown that mimicking neuronal activity by membrane depolarization rapidly induced the expression of a class of genes known as immediate early genes. Subsequently, it has been shown that neuronal activity triggers a temporal sequence of gene expression that has been suggested to play a role in mediating long-term adaptive responses. A major mechanism coupling neuronal electrical activity and the intracellular biochemical processes that culminate in gene expression is Ca2+ influx through plasma membrane Ca2+ channels. In this review, we delineate some of the reported mechanisms by which Ca2+ regulates gene expression: from its ability to activate specific intracellular signal transduction pathways to its ability to regulate the initiation, elongation, and translation of RNA transcripts. We will discuss some known mechanisms by which different patterns of Ca2+ influx, or Ca2+ influx through different types of channel, could generate distinct patterns of gene expression and how our understanding of Ca2+-regulated gene expression relates to larger questions of activity-dependent nervous system function.
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- 1998
19. The cost of antidepressant overdose
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David S. Finkbeiner, Dale A. D'Mello, and Keith N. Kocher
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Male ,medicine.medical_specialty ,Michigan ,Critical Care ,Poison control ,Venlafaxine ,Suicide, Attempted ,Drug overdose ,medicine ,Humans ,Retrospective Studies ,Bupropion ,Fluoxetine ,Sertraline ,business.industry ,Length of Stay ,medicine.disease ,Paroxetine ,Antidepressive Agents ,Psychiatry and Mental health ,Treatment Outcome ,Anesthesia ,Emergency medicine ,Costs and Cost Analysis ,Antidepressant ,Antidepressive Agents, Second-Generation ,Female ,Drug Overdose ,business ,medicine.drug - Abstract
Ninety percent of suicide attempts referred to a general hospital are by self-poisoning. Among women, drug overdose is the commonest means of suicide. In a retrospective naturalistic review of 200 patients who were treated in the Critical Care Unit of a general hospital following medication overdose, 12% were antidepressant overdoses. The mean duration of hospital stay for overdose with tricyclic antidepressants (TCA) was more than double that for overdose with selective serotonin reuptake inhibitors (SSRI) (7 vs 3 days; z = 2.20, p < 0.05). The dollar cost of hospital treatment for patients who overdosed on TCAs was four times greater than that for patients who overdosed on SSRIs ($22,923 vs $5,379; z = 2.30, p < 0.05). The tricyclic compounds clearly have a price advantage over more recently introduced antidepressant agents fluoxetine, sertraline, paroxetine, venlafaxine, and bupropion. The apparent cost advantage of prescribing a less expensive drug may be nullified by the cost associated with adverse consequences.
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- 1995
20. Optical Properties of Siloxene and Siloxene Derivates
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Martin S. Brandt, Martin Stutzmann, M. Rosenbauer, J. Weber, S. Finkbeiner, Peter Deák, H. D. Fuchs, and M.K. Kelly
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Diffraction ,Materials science ,Annealing (metallurgy) ,law ,Infrared spectroscopy ,Physical chemistry ,Electron paramagnetic resonance ,Porous silicon ,Luminescence ,Excitation ,Stoichiometry ,law.invention - Abstract
Structural and optical properties of siloxene (Si6O3H6) and its derivates obtained by chemical substitution or annealing are reviewed. The preparation of siloxene is briefly described and results of x-ray diffraction and infrared absorption are shown. The equilibrium structures of stoichiometric siloxene and the electronic properties of the corresponding two-, one-, and zero-dimensional Si-clusters are obtained from quantum chemical calculations. Experimental results concerning luminescence, luminescence excitation, absorption coefficients, magnetic resonance, and stability are discussed.
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- 1993
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21. Visible Luminescence from Porous Silicon and Siloxene: Recent Results
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H. D. Fuchs, Martin Stutzmann, S. Finkbeiner, K. Syassen, Martin S. Brandt, Manuel Cardona, S. Ernst, M. Rosenbauer, J. Weber, and Hans J. Queisser
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Materials science ,Photoluminescence ,Metastability ,Photoluminescence excitation ,Luminescence ,Porous silicon ,Photochemistry ,Porosity - Abstract
The optical properties of porous Si (p-Si) are compared to those of siloxene and its derivatives in order to gain more insight into the mechanism of the luminescence observed in p-Si. We report new results of photoluminescence (PL), photoluminescence excitation (PLE), time-dependent and pressure-dependent photoluminescence, and optically detected magnetic resonance (ODMR). Important information about the structural, electronic, and microscopic nature of the two classes of materials are deduced from these experiments. Annealed siloxene and p-Si show very similar properties, suggesting that siloxene-related structures, e.g. electrically isolated Si6-rings, might be responsible for the luminescence in p-Si. The Si-planes in as-prepared siloxene, with their green luminescence, are metastable and are readily oxidized into red-luminescent siloxene configurations.
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- 1992
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22. Reply to 'Comment on 'Resonantly excited photoluminescence spectra of porous silicon' '
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Martin Stutzmann, S. Finkbeiner, E. Bustarret, M. Rosenbauer, and J. Weber
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Materials science ,Photoluminescence ,Excited state ,Atomic physics ,Porous silicon ,Spectral line - Published
- 1997
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23. New Roles for Introns: Sites of Combinatorial Regulation of Ca2+- and Cyclic AMP-Dependent Gene Transcription
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S. Finkbeiner
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Cell Biology ,Molecular Biology ,Biochemistry - Published
- 2001
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24. The evaluation and management of patients with urinary tract calculous disease. Part I. Patient evaluation
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N K, Bissada, A S, Finkbeiner, and J F, Redman
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Adult ,Male ,Radiography ,Evaluation Studies as Topic ,Humans ,Urinary Calculi - Published
- 1977
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