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Additional file 1: Supplemental Figure 1. fMRI task paradigm. Supplemental Figure 2. Group difference in the Semantic Fluency-Fixation contrasts and its behavioral significance. One-way ANOVA, cluster-level P < 0.05, FWE corrected. Supplemental Table 1. The Post-hoc comparisons of the clinical characteristics in the China RSF multi-center cohort (Bonferroni corrected). Supplemental Table 2. Clinical characteristics of NC and AD patients in the Pitt center cohort. Supplemental Table 3. Correlation between PSD and cognition. Supplemental Table 4. The linear regression analysis of the variables correlated with PSD after adjusting for age. Supplemental Table 5. Demographic and neuropsychological/language characteristics of fMRI participants. Supplemental Table 6. Significant clusters in three linguistic tasks showing different activation by ANOVA analysis. Supplemental Table 7. Results of correlation analysis. # The spearman correlation coefficients were calculated between the average BOLD signal and the relevant fluency score of ACE-III. * The partial correlation coefficients were calculated between the average BOLD signal and PSD in the patient group. Supplemental Table 8. Post hoc analysis of cluster activation. Bold indicated significance (Bonferroni corrected).

Additional file 1.

Additional file 3: Table S1. Affiliations of the External reviewers for the Chinese version of FMD questionnaire.

Additional file 2: Fig. S1. Demographic information of the respondents. Fig. S2. Findings necessary for clinically definite diagnosis of FMD. Fig. S3. Suggestion or placebo used in documenting and diagnosing FMD. Fig. S4. Refer patients for treatment.

Additional file 4: Table S2. Other issues important in the diagnosis and treatment of FMD that have not been addressed (Answers of Item-21).