Author: "Parker, G. A." / Language: undetermined - Searchworks@Jio Institute Digital Library Search Results

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137 results on '"Parker, G. A."'

1. Configuration of digital and physical infrastructure platforms: Private and public perspectives

Author: Joglekar, N, Anderson, EG, Lee, K, Parker, G, Settanni, E, Srai, JS, Settanni, Ettore [0000-0001-5174-9423], Srai, Jag [0000-0003-2277-2127], and Apollo - University of Cambridge Repository
Subjects: physical infrastructure, platforms, Management of Technology and Innovation, digital infrastructure, Management Science and Operations Research, supply chains, Industrial and Manufacturing Engineering, public policies
Abstract: Investments in infrastructure platforms aim to enhance supply chain performance. We build on network-based models of platform growth to characterize configurations of digital and physical supply chain infrastructure. We define cross-platform effect as the value accrued by a platform on one side of a multiplatform configuration as capability for the opposite side platform evolves. We posit that aligning cross-platform effect across digital and physical infrastructure enhances system outcomes. Our arguments are informed by evidence on private–public partnerships for developing production and distribution infrastructure in the pharmaceutical industry. We identify enablers and inhibitors for cross-platform effects within these data in terms of product and process technology readiness, path-dependent standards creation, organizational alignment, regulatory fragmentation, and the desire towards such infrastructure yielding resilient outcomes. Implications of findings, in shaping analytical and empirical research on managing supply chain infrastructure, at the levels of firms, industries, and public policies are discussed.
Published: 2023
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2. Observation of Seasonal Variations of the Flux of High-Energy Atmospheric Neutrinos with IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Hauser, S., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Atmospheric muon neutrinos are produced by meson decays in cosmic-ray-induced air showers. The flux depends on meteorological quantities such as the air temperature, which affects the density of air. Competition between decay and re-interaction of those mesons in the first particle production generations gives rise to a higher neutrino flux when the air density in the stratosphere is lower, corresponding to a higher temperature. A measurement of a temperature dependence of the atmospheric $\nu_{\mu}$ flux provides a novel method for constraining hadro\-nic interaction models of air showers. It is particularly sensitive to the production of kaons. Studying this temperature dependence for the first time requires a large sample of high-energy neutrinos as well as a detailed understanding of atmospheric properties. We report the significant ($> 10 \sigma$) observation of a correlation between the rate of more than 260,000 neutrinos, detected by IceCube between 2012 and 2018, and atmospheric temperatures of the stratosphere, measured by the Atmospheric Infrared Sounder (AIRS) instrument aboard NASA's AQUA satellite. For the observed 10$\%$ seasonal change of effective atmospheric temperature we measure a 3.5(3)$\%$ change in the muon neutrino flux. This observed correlation deviates by about 2-3 standard deviations from the expected correlation of 4.3$\%$ as obtained from theoretical predictions under the assumption of various hadronic interaction models, Comment: Preprint submitted to EPJC
Published: 2023
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3. A Search for IceCube sub-TeV Neutrinos Correlated with Gravitational-Wave Events Detected By LIGO/Virgo

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Jansson, M., Japaridze, G. S., Jayakumar, K., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlüter, B., Schlüter, F., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, F., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The LIGO/Virgo collaboration published the catalogs GWTC-1, GWTC-2.1 and GWTC-3 containing candidate gravitational-wave (GW) events detected during its runs O1, O2 and O3. These GW events can be possible sites of neutrino emission. In this paper, we present a search for neutrino counterparts of 90 GW candidates using IceCube DeepCore, the low-energy infill array of the IceCube Neutrino Observatory. The search is conducted using an unbinned maximum likelihood method, within a time window of 1000 s and uses the spatial and timing information from the GW events. The neutrinos used for the search have energies ranging from a few GeV to several tens of TeV. We do not find any significant emission of neutrinos, and place upper limits on the flux and the isotropic-equivalent energy emitted in low-energy neutrinos. We also conduct a binomial test to search for source populations potentially contributing to neutrino emission. We report a non-detection of a significant neutrino-source population with this test., Comment: Submitted to ApJ
Published: 2023
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4. Search for Extended Sources of Neutrino Emission in the Galactic Plane with IceCube

Author: Abbasi, R., Ackermann, M., Adams, J., Agarwalla, S. K., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Amin, N. M., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Beise, J., Bellenghi, C., Benning, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Butterfield, D., Campana, M. A., Carloni, K., Carnie-Bronca, E. G., Chattopadhyay, S., Chau, N., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado, D., Deng, S., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Domi, A., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Ellinger, E., Mentawi, S. El, Elsässer, D., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fang, K., Farrag, K., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Fritz, A., Fürst, P., Gallagher, J., Ganster, E., Garcia, A., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Gries, O., Griffin, S., Griswold, S., Groth, K. M., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Heyer, N., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hori, S., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Ishihara, A., Jacquart, M., Janik, O., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Zathul, A. Khatee, Kheirandish, A., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krishnamoorthi, J., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Latseva, S., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Luszczak, W., Lyu, Y., Madsen, J., Mahn, K. B. M., Makino, Y., Manao, E., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Merckx, Y., Merten, L., Micallef, J., Mitchell, J., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Nakos, M., Naumann, U., Necker, J., Negi, A., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Novikov, A., Nowicki, S. C., Pollmann, A. Obertacke, O'Dell, V., Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pizzuto, A., Plum, M., Pontén, A., Popovych, Y., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Riedel, B., Rifaie, A., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlickmann, L., Schlüter, B., Schlüter, F., Schmeisser, N., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seikh, M., Seunarine, S., Shah, R., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Soldin, P., Sommani, G., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thiesmeyer, M., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upadhyay, A. K., Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Venugopal, M., Vereecken, M., Verpoest, S., Veske, D., Vijai, A., Walck, C., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wen, A. Y., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Witthaus, L., Wolf, A., Wolf, M., Wrede, G., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Young, R., Yu, F., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Zilberman, P., and Zimmerman, M.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), High Energy Physics - Experiment (hep-ex), Astrophysics of Galaxies (astro-ph.GA), FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment
Abstract: The Galactic plane, harboring a diffuse neutrino flux, is a particularly interesting target to study potential cosmic-ray acceleration sites. Recent gamma-ray observations by HAWC and LHAASO have presented evidence for multiple Galactic sources that exhibit a spatially extended morphology and have energy spectra continuing beyond 100 TeV. A fraction of such emission could be produced by interactions of accelerated hadronic cosmic rays, resulting in an excess of high-energy neutrinos clustered near these regions. Using 10 years of IceCube data comprising track-like events that originate from charged-current muon neutrino interactions, we perform a dedicated search for extended neutrino sources in the Galaxy. We find no evidence for time-integrated neutrino emission from the potential extended sources studied in the Galactic plane. The most significant location, at 2.6$\sigma$ post-trials, is a 1.7$^\circ$ sized region coincident with the unidentified TeV gamma-ray source 3HWC J1951+266. We provide strong constraints on hadronic emission from several regions in the Galaxy., Comment: 13 pages, 4 figures, 5 tables including an appendix. Submitted to Astrophysical Journal
Published: 2023
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5. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage

Author: Parker G. Jobin, Simran K. Rai, Peter A. Bell, Nam Hoon Kwon, Nestor Solis, Georgina S. Butler, Yoan Machado, Sunghoon Kim, and Christopher M. Overall
Subjects: 0301 basic medicine, Chemokine, THP-1 Cells, Matrix metalloproteinase, Medical and Health Sciences, Biochemistry, Monocytes, Substrate Specificity, Tyrosine-tRNA Ligase, Models, Enzyme Stability, multifunctional protein, Tyrosine, innate immunity, biology, Chemistry, Chemotaxis, NF-kappa B, Biological Sciences, medicine.anatomical_structure, Inflammation Mediators, Chemokines, Signal Transduction, proteolysis, Biochemistry & Molecular Biology, matrix metalloproteinase, toll-like receptor (TLR), macrophage, Models, Biological, Macrophage chemotaxis, Proinflammatory cytokine, 03 medical and health sciences, medicine, Extracellular, Humans, moonlighting proteins, Interleukin 8, Molecular Biology, 030102 biochemistry & molecular biology, Tumor Necrosis Factor-alpha, Macrophages, aminoacyl tRNA synthetase, Monocyte, matrix metalloproteinase (MMP), Cell Biology, Biological, Molecular biology, Matrix Metalloproteinases, Toll-Like Receptor 2, 030104 developmental biology, inflammation, Chemical Sciences, biology.protein, toll-like receptor, Extracellular Space
Abstract: Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that extracellular tyrosyl-tRNA synthetase (YRS) exhibited proinflammatory activities. In addition to acting as a monocyte/macrophage chemoattractant, YRS initiated signaling through Toll-like receptor 2 (TLR2) resulting in NF-κB activation and release of tumor necrosis factor α (TNFα) and multiple chemokines, including MIP-1α/β, CXCL8 (IL8), and CXCL1 (KC) from THP1 monocyte and peripheral blood mononuclear cell–derived macrophages. Furthermore, YRS up-regulated matrix metalloproteinase (MMP) activity in a TNFα-dependent manner in M0 macrophages. Because MMPs process a variety of intracellular proteins that also exhibit extracellular moonlighting functions, we profiled 10 MMPs for YRS cleavage and identified 55 cleavage sites by amino-terminal oriented mass spectrometry of substrates (ATOMS) positional proteomics and Edman degradation. Stable proteoforms resulted from cleavages near the start of the YRS C-terminal EMAPII domain. All of the MMPs tested cleaved at ADS386↓387LYV and VSG405↓406LVQ, generating 43- and 45-kDa fragments. The highest catalytic efficiency for YRS was demonstrated by MMP7, which is highly expressed by monocytes and macrophages, and by neutrophil-specific MMP8. MMP-cleaved YRS enhanced TLR2 signaling, increased TNFα secretion from macrophages, and amplified monocyte/macrophage chemotaxis compared with unprocessed YRS. The cleavage of YRS by MMP8, but not MMP7, was inhibited by tyrosine, a substrate of the YRS aminoacylation reaction. Overall, the proinflammatory activity of YRS is enhanced by MMP cleavage, which we suggest forms a feed-forward mechanism to promote inflammation.
Published: 2020

6. Searches for Neutrinos from LHAASO ultra-high-energy γ-ray sources using the IceCube Neutrino Observatory

Author: Abbasi, R., Ackermann, M., Adams, J., Aggarwal, N., Aguilar, J. A., Ahlers, M., Alameddine, J. M., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Athanasiadou, S., Axani, S. N., Bai, X., V., A. Balagopal, Baricevic, M., Barwick, S. W., Basu, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Beise, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bontempo, F., Book, J. Y., Borowka, J., Meneguolo, C. Boscolo, Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Braun, J., Brinson, B., Brostean-Kaiser, J., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chang, Y. L., Chen, C., Chen, Z., Chirkin, D., Choi, S., Clark, B. A., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Countryman, S., Cowen, D. F., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., DuVernois, M. A., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goehlke, N., Gonzalez, J. G., Goswami, S., Grant, D., Gray, S. J., Grégoire, T., Griffin, S., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hamdaoui, H., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Hatch, P., Haungs, A., Helbing, K., Hellrung, J., Henningsen, F., Heuermann, L., Hickford, S., Hidvegi, A., Hill, C., Hill, G. C., Hoffman, K. D., Hoshina, K., Hou, W., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kelley, J. L., Kheirandish, A., Kin, K., Kiryluk, J., Klein, S. R., Kochocki, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kruiswijk, K., Krupczak, E., Kumar, A., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lamoureux, M., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., DeHolton, K. Leonard, Leszczyńska, A., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Love, C., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Sainte, W. Marie, Mariş, I. C., Marka, S., Marka, Z., Marsee, M., Martinez-Soler, I., Maruyama, R., Mayhew, F., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Merckx, Y., Merten, L., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morii, Y., Morse, R., Moulai, M., Mukherjee, T., Naab, R., Nagai, R., Naumann, U., Nayerhoda, A., Necker, J., Neumann, M., Niederhausen, H., Nisa, M. U., Noell, A., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., Orsoe, R., Osborn, J., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peterson, J., Philippen, S., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Pries, B., Procter-Murphy, R., Przybylski, G. T., Raab, C., Rack-Helleis, J., Rameez, M., Rawlins, K., Rechav, Z., Rehman, A., Reichherzer, P., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Rodan, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ruohan, L., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Salazar-Gallegos, D., Sampathkumar, P., Herrera, S. E. Sanchez, Sandrock, A., Santander, M., Sarkar, S., Savelberg, J., Savina, P., Schaufel, M., Schieler, H., Schindler, S., Schlueter, B., Schmidt, T., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Shimizu, N., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Søgaard, A., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stamatikos, M., Stanev, T., Stein, R., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Thompson, W. G., Thwaites, J., Tilav, S., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tung, C. F., Turcotte, R., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Upshaw, K., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Vara, J., Veitch-Michaelis, J., Verpoest, S., Veske, D., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Willey, N., Williams, D. R., Wolf, M., Wrede, G., Wulff, J., Xu, D. L., Xu, X. W., Yanez, J. P., Yildizci, E., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and Zhelnin, P.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), accelerator, air, FOS: Physical sciences, acceleration, showers, suppression, tracks, UHE, IceCube, observatory, flux, cosmic radiation, stacking, gas, supernova, high [energy], TeV, galaxy, pulsar
Abstract: Galactic PeVatrons are Galactic sources theorized to accelerate cosmic rays up to PeV in energy. The accelerated cosmic rays are expected to interact hadronically with nearby ambient gas or the interstellar medium, resulting in γ-rays and neutrinos. Recently, the Large High Altitude Air Shower Observatory (LHAASO) identified 12 γ-ray sources with emissions above 100 TeV, making them candidates for PeV cosmic-ray accelerators (PeVatrons). While at these high energies the Klein-Nishina effect suppresses exponentially leptonic emission from Galactic sources, evidence for neutrino emission would unequivocally confirm hadronic acceleration. Here, we present the results of a search for neutrinos from these γ-ray sources and stacking searches testing for excess neutrino emission from all 12 sources as well as their subcatalogs of supernova remnants and pulsar wind nebulae with 11 years of track events from the IceCube Neutrino Observatory. No significant emissions were found. Based on the resulting limits, we place constraints on the fraction of γ-ray flux originating from the hadronic processes in the Crab Nebula and LHAASOJ2226+6057.
Published: 2022
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7. Search for neutrino emission from cores of Active Galactic Nuclei

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alameddine, J. M., Alispach, C., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., Balagopal V., A., Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Brinson, B., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Delgado López, D., Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Martinez-Soler, I., Maruyama, R., Mase, K., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyễn, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Obertacke Pollmann, A., Oehler, M., Oeyen, B., Olivas, A., O’Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez de los Heros, C., Peters, L., Peterson, J., Philippen, S., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Saffer, J., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schindler, S., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Elementary Particle Physics, Physics, and Vriendenkring VUB
Subjects: background [atmosphere], HIGH-ENERGY NEUTRINOS, FLUX, Astrophysics::High Energy Astrophysical Phenomena, pole, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, power spectrum, neutrino: flux, ICECUBE, blazar, IceCube, particle: acceleration, accretion, Astronomi, astrofysik och kosmologi, atmosphere: background, TeV, Astronomy, Astrophysics and Cosmology, ddc:530, AGN, detector [neutrino], X-ray: flux, Astrophysics::Galaxy Astrophysics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), radio wave, flux [X-ray], Physics, flux [neutrino], EVOLUTION, color, MODEL, neutrino: detector, GAMMA-RAY, QUASARS, Physics and Astronomy, gamma ray, cosmic radiation, infrared, LUMINOSITY, High Energy Physics::Experiment, Astrophysics - High Energy Astrophysical Phenomena, acceleration [particle]
Abstract: Physical review / D 106(2), 022005 (2022). doi:10.1103/PhysRevD.106.022005, The sources of the majority of the high-energy astrophysical neutrinos observed with the IceCube neutrino telescope at the South Pole are unknown. So far, only a flaring gamma-ray blazar was compellingly associated with the emission of high-energy neutrinos. However, several studies suggest that the neutrino emission from the gamma-ray blazar population only accounts for a small fraction of the total astrophysical neutrino flux. In this work we probe the production of high-energy neutrinos in the cores of active galactic nuclei (AGN), induced by accelerated cosmic rays in the accretion disk region. We present a likelihood analysis based on eight years of IceCube data, searching for a cumulative neutrino signal from three AGN samples created for this work. The neutrino emission is assumed to be proportional to the accretion disk luminosity estimated from the soft x-ray flux. Next to the observed soft x-ray flux, the objects for the three samples have been selected based on their radio emission and infrared color properties. For the largest sample in this search, an excess of high-energy neutrino events with respect to an isotropic background of atmospheric and astrophysical neutrinos is found, corresponding to a post-trial significance of 2.60σ. If interpreted as a genuine signal with the assumptions of a proportionality of x-ray and neutrino fluxes and a model for the subthreshold flux distribution, then this observation implies that at 100 TeV, 27%–100% of the observed neutrinos arise from particle acceleration in the core of AGN at 1σ confidence interval., Published by Inst., Melville, NY
Published: 2022

8. Evidence for neutrino emission from the nearby active galaxy NGC 1068

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alameddine, J. M., Alispach, C., Alves Jr., A. A., Amin, N. M., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Brinson, B., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Martinez-Soler, I., Maruyama, R., Mase, K., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Nahnhauer, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peters, L., Peterson, J., Philippen, S., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Rack-Helleis, J., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schieler, H., Schindler, S., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Valtonen-Mattila, N., Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., Vriendenkring VUB, Elementary Particle Physics, and Physics
Subjects: astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Multidisciplinary, hep-ex, astro-ph.GA, FOS: Physical sciences, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Astrophysics of Galaxies (astro-ph.GA), Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), astro-ph.IM
Abstract: We report three searches for high energy neutrino emission from astrophysical objects using data recorded with IceCube between 2011 and 2020. Improvements over previous work include new neutrino reconstruction and data calibration methods. In one search, the positions of 110 a priori selected gamma-ray sources were analyzed individually for a possible surplus of neutrinos over atmospheric and cosmic background expectations. We found an excess of $79_{-20}^{+22}$ neutrinos associated with the nearby active galaxy NGC 1068 at a significance of 4.2$\,\sigma$. The excess, which is spatially consistent with the direction of the strongest clustering of neutrinos in the Northern Sky, is interpreted as direct evidence of TeV neutrino emission from a nearby active galaxy. The inferred flux exceeds the potential TeV gamma-ray flux by at least one order of magnitude., Comment: for the published version of this article visit the Science web portal: https://www.science.org/doi/10.1126/science.abg3395 , or the IceCube database (no subscription needed): https://icecube.wisc.edu/science/publications/
Published: 2022
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9. Improved Characterization of the Astrophysical Muon-neutrino Flux with 9.5 Years of IceCube Data

Author: Abbasi, R., Ackermann, Markus, Andeen, K., Filimonov, K., Finley, C., Fischer, Leander, Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Anderson, T., Ganster, E., Garcia, Alfonso, Garrappa, Simone, Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Gonzalez, J. G., Goswami, S., Anton, G., Grant, D., Grégoire, T., Griswold, S., Günther, C., Gutjahr, P., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Argüelles, C., Minh, M. Ha, Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Ashida, Y., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Axani, S., Hultqvist, K., Hünnefeld, M., Hussain, R., Hymon, K., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Bai, X., Jin, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Kardum, L., Karg, T., Karl, M., V., A. Balagopal, Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Barbano, A., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Barwick, S. W., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Adams, J., Bastian-Querner, Benjamin, Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Basu, V., Ludwig, A., Luszczak, W., Lyu, Y., Ma, Wing Yan, Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Martinez-Soler, I., Baur, S., Maruyama, R., Mase, K., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Mechbal, S., Medina, A., Meier, M., Meighen-Berger, S., Bay, R., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, Richard, Nagai, R., Naumann, U., Necker, Jannis David, Beatty, J. J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Pollmann, A. Obertacke, Oehler, M., Oeyen, B., Olivas, A., O'Sullivan, E., Pandya, H., Becker, K.-H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Heros, C. Pérez de los, Peters, L., Peterson, J., Philippen, S., Pieper, S., Tjus, J. Becker, Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Bellenghi, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, Simeon, BenZvi, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Berley, D., Cantu, D. Rysewyk, Safa, I., Saffer, J., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Aguilar, J. A., Bernardini, E., Schieler, H., Schindler, S., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Besson, D. Z., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Binder, G., Spiczak, G. M., Spiering, Christian, Stachurska, Juliana, Stamatikos, M., Stanev, T., Stein, Robert, Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Bindig, D., Stuttard, T., Sullivan, G. W., Taboada, I., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tönnis, C., Toscano, S., Tosi, D., Blaufuss, E., Trettin, Alexander, Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Elorrieta, M. A. Unland, Valtonen-Mattila, N., Blot, Summer, Vandenbroucke, J., van Eijndhoven, N., Vannerom, D., Santen, Jakob van, Verpoest, S., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Boddenberg, M., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Bontempo, F., Wrede, G., Wulff, J., Xu, X. W., Yanez, J. P., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., Zhelnin, P., IceCube Collaboration, Borowka, J., Böser, S., Ahlers, M., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, Federica, Braun, J., Brinson, B., Bron, S., Brostean-Kaiser, Jannes, Browne, S., Burgman, A., Ahrens, M., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chen, Z., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Alameddine, J. M., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., Alispach, C., De Clercq, C., DeLaunay, J. J., López, D. Delgado, Dembinski, H., Deoskar, K., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., Alves Jr., A. A., DeYoung, T., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Amin, N. M., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fedynitch, A., Feigl, N., Fiedlschuster, S., Fienberg, A. T., Vriendenkring VUB, Elementary Particle Physics, and Physics
Subjects: background [atmosphere], Astrophysics::High Energy Astrophysical Phenomena, energy spectrum, FOS: Physical sciences, 330, High-Energy Phenomena and Fundamental Physics, power spectrum, GeV, IceCube, muon: tracks, Astronomi, astrofysik och kosmologi, atmosphere: background, TeV, Astronomy, Astrophysics and Cosmology, ddc:530, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), SPECTRUM, energy: high, Physics, parametrization, Astronomy and Astrophysics, ddc, flux, observatory, Physics and Astronomy, Space and Planetary Science, ddc:520, high [energy], spectral, High Energy Physics::Experiment, tracks [muon], Astrophysics - High Energy Astrophysical Phenomena
Abstract: The astrophysical journal 928(1), 50 (2022). doi:10.3847/1538-4357/ac4d29, We present a measurement of the high-energy astrophysical muon–neutrino flux with the IceCube Neutrino Observatory. The measurement uses a high-purity selection of 650k neutrino-induced muon tracks from the northern celestial hemisphere, corresponding to 9.5 yr of experimental data. With respect to previous publications, the measurement is improved by the increased size of the event sample and the extended model testing beyond simple power-law hypotheses. An updated treatment of systematic uncertainties and atmospheric background fluxes has been implemented based on recent models. The best-fit single power-law parameterization for the astrophysical energy spectrum results in a normalization of and a spectral index , constrained in the energy range from 15 TeV to 5 PeV. The model tests include a single power law with a spectral cutoff at high energies, a log-parabola model, several source-class-specific flux predictions from the literature, and a model-independent spectral unfolding. The data are consistent with a single power-law hypothesis, however, spectra with softening above one PeV are statistically more favorable at a two-sigma level., Published by Univ., Chicago, Ill. [u.a.]
Published: 2021

10. Simulation study for the future IceCube-Gen2 surface array

Author: Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Allison, P., Alves, A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Arlen, T. C., Ashida, Y., Axani, S., Bai, X., Balagopal, A. V., Barbano, A., Bartos, I., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H, Becker Tjus, J., Bellenghi, C., Benzvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Bishop, A., Blaufuss, E., Blot, S., Boddenberg, M., Bohmer, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Cataldo, M., Chen, C., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Clark, R., Classen, L., Coleman, A., Collin, G. H., Connolly, A., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., Deaconu, C., Clercq, C., Kockere, S., Delaunay, J. J., Dembinski, H., Deoskar, K., Ridder, S., Desai, A., Desiati, P., Vries, K. D., Wasseige, G., With, M., Deyoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., Duvernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evans, J. J., Evenson, P. A., Fan, K. L., Farrag, K., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gartner, A., Gerhardt, L., Gernhaeuser, R., Ghadimi, A., Giri, P., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Gündüz, M., Günther, C., Haack, C., Hallgren, A., Halliday, R., Hallmann, S., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Haugen, J., Haungs, A., Hauser, S., Hebecker, D., Heinen, D., Helbing, K., Hendricks, B., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, B., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Holzapfel, K., Hoshina, K., Huang, F., Huber, M., Huber, T., Huege, T., Hughes, K., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Kalekin, O., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katori, T., Katz, U., Kauer, M., Keivani, A., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Krauss, C. B., Kravchenko, I., Krebs, R., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Losecco, J., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mandalia, S., Mariş, I. C., Marka, S., Marka, Z., Maruyama, R., Mase, K., Mcelroy, T., Mcnally, F., Mead, J. V., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Meyers, Z., Micallef, J., Mockler, D., Teresa Montaruli, Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nelles, A., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Oberla, E., Obertacke Pollmann, A., Oehler, M., Olivas, A., Omeliukh, A., O Sullivan, E., Pandya, H., Pankova, D. V., Papp, L., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez Los Heros, C., Peters, L., Petersen, T. C., Peterson, J., Philippen, S., Pieloth, D., Pieper, S., Pinfold, J. L., Pittermann, M., Pizzuto, A., Plaisier, I., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Pries, B., Przybylski, G. T., Pyras, L., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Riegel, M., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Saffer, J., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Sandstrom, P., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schindler, S., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Shaevitz, M. H., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smith, D., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Söldner-Rembold, S., Southall, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Taketa, A., Tanaka, H. K. M., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Torres, J., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Valtonen-Mattila, N., Vandenbroucke, J., Eijndhoven, N., Vannerom, D., Santen, J., Veberic, D., Verpoest, S., Vieregg, A., Vraeghe, M., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weinstock, L., Weiss, M. J., Weldert, J., Welling, C., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wissel, S., Wolf, M., Woschnagg, K., Wrede, G., Wren, S., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and Zierke, S.
Subjects: Surface (mathematics), accelerator, air, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Cosmic ray, IceCube Neutrino Observatory, Optics, surface [IceCube], surface [detector], optical, ddc:530, numerical calculations, Instrumentation and Methods for Astrophysics (astro-ph.IM), enhancement, scintillation counter, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Scintillation, showers: atmosphere, detector: surface, business.industry, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, IceCube: surface, observatory, cosmic radiation, High Energy Physics::Experiment, galaxy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, business, Energy (signal processing), atmosphere [showers]
Abstract: The next generation of the IceCube Neutrino Observatory, IceCube-Gen2, will constitute a much larger detector, increasing the rate of high-energy neutrinos. IceCube-Gen2 will address the long-standing questions about astrophysical accelerators. The experiment will also include a surface air-shower detector which will allow for measurements of cosmic rays in the energy region where a transition between Galactic and extragalactic accelerators is expected. As a baseline design for the surface detector, we consider a surface array above the optical in-ice array consisting of the same type of stations used for the IceTop enhancement, i.e., scintillation detectors and radio antennas. In order to better understand the capabilities of such an array, we performed simulations of its response to air showers, including both detector types. We will show the results of this simulation study and discuss the prospects for the surface array of IceCube-Gen2., Comment: Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06968 for all IceCube-Gen2 contributions
Published: 2021

11. Performance of the D-Egg optical sensor for the IceCube-Upgrade

Author: Hill, C., Meier, M., Nagai, R., Kin, K., Shimizu, N., Ishihara, A., Yoshida, S., Anderson, T., Braun, J., Fienberg, A., Weber, J., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves, Jr, A.A., Amin, N. M., An, R., Andeen, K., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., Balagopal, A. V., Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., Vries, K. D. de, Wasseige, G. de, With, M. de, DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Gündüz, M., Günther, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Medina, A., Meighen-Berger, S., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O’Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez de los Heros, C., Peters, L., Peterson, J., Philippen, S., Pieloth, D., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Saffer, J., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schindler, S., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Valtonen-Mattila, N., Vandenbroucke, J., Eijndhoven, N. van, Vannerom, D., Santen, J. van, Verpoest, S., Vraeghe, M., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yu, S., Yuan, T., Zhang, Z., and IceCube Collaboration
Subjects: Production line, Photomultiplier, photomultiplier, Photon, data acquisition, business.industry, Computer science, Physics, fabrication, Photocathode, Upgrade, Data acquisition, analog-to-digital converter, IceCube: upgrade, electronics: readout, upgrade [IceCube], ddc:530, Electronics, Instrumentation (computer programming), readout [electronics], business, performance, Computer hardware
Abstract: 37. International Cosmic Ray Conference, ICRC 2021, Berlin, Germany, 15 Jul 2021 - 22 Jul 2021; Proceedings of Science 395, 1042 (2022). doi:10.22323/1.395.1042 special issue: "37th International Cosmic Ray Conference : ICRC2021 : 12-23 July 2021 : Berlin, Germany - Online / Editorial Board: Alexander Kappes, Institut für Kernphysik, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany ; Bianca Keilhauer, Karlsruhe Institute of Technology, Institute for Astroparticle Physics (IAP)", Published by SISSA, Trieste
Published: 2021

12. Measurement of the high-energy all-flavor neutrino-nucleon cross section with IceCube

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves, A. A., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Axani, S., Bai, X., Balagopal V., A., Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Campana, M. A., Chen, C., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., Vries, K. D. de, Wasseige, G. de, With, M. de, DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evans, J., Evenson, P. A., Fahey, S., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyễn, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O’Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Pérez de los Heros, C., Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Unland Elorrieta, M. A., Usner, M., Vandenbroucke, J., Eijk, D. van, Eijndhoven, N. van, Vannerom, D., Santen, J. van, Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: Physics::Instrumentation and Detectors, ice, interaction [neutrino nucleon], 01 natural sciences, Particle identification, IceCube, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Astronomi, astrofysik och kosmologi, Subatomic Physics, Astronomy, Astrophysics and Cosmology, detector [neutrino], astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, hep-ph, Observable, ddc, observatory, High Energy Physics - Phenomenology, Neutrino detector, statistics, decay [tau], Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Nucleon, data analysis method, Particle physics, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, ACCELERATION, Bayesian [statistical analysis], IceCube Neutrino Observatory, Standard Model, cross section [neutrino nucleon], 0103 physical sciences, ddc:530, GLASHOW RESONANCE, 010306 general physics, hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, flavor [neutrino], flux [neutrino], frequentist [statistical analysis], Physics and Astronomy, energy [neutrino], High Energy Physics::Experiment, Event (particle physics), experimental results
Abstract: The flux of high-energy neutrinos passing through the Earth is attenuated due to their interactions with matter. The interaction rate is modulated by the neutrino interaction cross section and affects the flux arriving at the IceCube Neutrino Observatory, a cubic-kilometer neutrino detector embedded in the Antarctic ice sheet. We present a measurement of the neutrino cross section between 60 TeV and 10 PeV using the high-energy starting events (HESE) sample from IceCube with 7.5 years of data. The result is binned in neutrino energy and obtained using both Bayesian and frequentist statistics. We find it compatible with predictions from the Standard Model. Flavor information is explicitly included through updated morphology classifiers, proxies for the the three neutrino flavors. This is the first such measurement to use the three morphologies as observables and the first to account for neutrinos from tau decay., Comment: 10 pages, 7 figures, 2 tables. This article is supported by a long-form paper that discusses in high-energy starting event selection titled: "The IceCube high-energy starting event sample: Description and flux characterization with 7.5 years of data"
Published: 2021

13. Design, performance, and analysis of a measurement of optical properties of antarctic ice below 400 nm

Author: Brostean-Kaiser, J., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves, A.A., Amin, N. M., An, R., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., Balagopal, A. V., Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K.-H., Becker Tjus, J., Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Bron, S., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., Vries, K. D. De, Wasseige, G. De, With, M. De, DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Gündüz, M., Günther, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., McElroy, T., McNally, F., Mead, J. V., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Micallef, J., Mockler, D., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O’Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez De Los Heros, C., Peters, L., Peterson, J., Philippen, S., Pieloth, D., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Saffer, J., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schindler, S., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Valtonen-Mattila, N., Vandenbroucke, J., Eijndhoven, N. Van, Vannerom, D., Santen, J. Van, Verpoest, S., Vraeghe, M., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yu, S., Yuan, T., Zhang, Z., and IceCube Collaboration
Subjects: Physics, Physics - Instrumentation and Detectors, Photon, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Photodetector, Instrumentation and Detectors (physics.ins-det), IceCube Neutrino Observatory, Wavelength, Optics, Calibration, ddc:530, Astrophysics - Instrumentation and Methods for Astrophysics, business, Absorption (electromagnetic radiation), Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation
Abstract: The IceCube Neutrino Observatory, located at the geographic South Pole, is the world's largest neutrino telescope, instrumenting 1 km$^3$ of Antarctic ice with 5160 photosensors to detect Cherenkov light. For the IceCube Upgrade, to be deployed during the 2022-23 polar field season, and the enlarged detector IceCube-Gen2 several new optical sensor designs are under development. One of these optical sensors, the Wavelength-shifting Optical Module (WOM), uses wavelength-shifting and light-guiding techniques to measure Cherenkov photons in the UV range from 250 nm to 380 nm. In order to understand the potential gains from this new technology, a measurement of the scattering and absorption lengths of UV light was performed in the SPICEcore borehole at the South Pole during the winter seasons of 2018/2019 and 2019/2020. For this purpose, a calibration device with a UV light source and a detector using the wavelength shifting technology was developed. We present the design of the developed calibration device, its performance during the measurement campaigns, and the comparison of data to a Monte Carlo simulation., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions
Published: 2021

14. Hemangioblastoma of Cerebral Aqueduct Removed via Sitting, Supracerebellar Intracollicular Approach

Author: Kar Ming Fung, Michael E. Sughrue, Parker G. Allan, Hannah B. Homburg, Robert G. Briggs, B. David Maxwell, Ryan G. Jones, and Andrew K. Conner
Subjects: Male, medicine.medical_specialty, Sitting, Neurosurgical Procedures, Patient Positioning, Lesion, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Cerebellum, Hemangioblastoma, otorhinolaryngologic diseases, medicine, Humans, Cerebellar Neoplasms, Aged, Sitting Position, business.industry, Cerebral Aqueduct, medicine.disease, Inferior Colliculi, Hydrocephalus, 030220 oncology & carcinogenesis, Cerebral aqueduct, Surgery, Histopathology, Neurology (clinical), Radiology, medicine.symptom, business, Complication, 030217 neurology & neurosurgery
Abstract: Background Tumors protruding into the cerebral aqueduct are rare, and tumors arising from within the cerebral aqueduct are rarer still. Case Description In this report, we discuss the presentation and clinical outcome of a 65-year-old man who presented to us with symptoms of hydrocephalus. Prior imaging had revealed a small enhancing nodule within the cerebral aqueduct. In the 6 months between initial imaging and our seeing the patient, the tumor demonstrated substantial interval growth, so the patient was offered resection. The tumor was accessed using a sitting, supracerebellar, intracollicular approach, which allowed for gross total resection of the mass without complication. Histopathology later revealed the lesion to be a hemangioblastoma. Two years after surgery, the patient was doing well with no neurologic deficits. Conclusions We report the first case of an aqueductal hemangioblastoma and describe our use of a sitting, supracerebellar, intracollicular approach to access tumors occupying this cerebrospinal fluid space.
Published: 2019

15. Reconstructing Neutrino Energy using CNNs for GeV Scale IceCube Events

Author: Micallef, J., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Alves, A. A., Amin, N. M., An, R., Andeen, K., Anderson, T., Anton, G., Argüelles, C., Ashida, Y., Axani, S., Bai, X., Balagopal, A. V., Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H, Becker Tjus, J., Bellenghi, C., Benzvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Boddenberg, M., Bontempo, F., Borowka, J., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Browne, S., Burgman, A., Burley, R. T., Busse, R. S., Campana, M. A., Carnie-Bronca, E. G., Chen, C., Chirkin, D., Choi, K., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dappen, C., Dave, P., Clercq, C., Delaunay, J. J., Dembinski, H., Deoskar, K., Ridder, S., Desai, A., Desiati, P., Vries, K. D., Wasseige, G., With, M., Deyoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dittmer, M., Dujmovic, H., Dunkman, M., Duvernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Erpenbeck, H., Evans, J., Evenson, P. A., Fan, K. L., Fazely, A. R., Fiedlschuster, S., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Fürst, P., Gaisser, T. K., Gallagher, J., Ganster, E., Garcia, A., Garrappa, S., Gerhardt, L., Ghadimi, A., Glaser, C., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griswold, S., Gündüz, M., Günther, C., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Ha Minh, M., Hanson, K., Hardin, J., Harnisch, A. A., Haungs, A., Hauser, S., Hebecker, D., Helbing, K., Henningsen, F., Hettinger, E. C., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kin, K., Kintscher, T., Kiryluk, J., Klein, S. R., Koirala, R., Kolanoski, H., Kontrimas, T., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Kozynets, T., Kun, E., Kurahashi, N., Lad, N., Lagunas Gualda, C., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Lee, J. W., Leonard, K., Leszczyńska, A., Li, Y., Lincetto, M., Liu, Q. R., Liubarska, M., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Mcelroy, T., Mcnally, F., Mead, J. V., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Mockler, D., Teresa Montaruli, Moore, R. W., Morse, R., Moulai, M., Naab, R., Nagai, R., Naumann, U., Necker, J., Nguyên, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O’sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Paul, L., Pérez Los Heros, C., Peters, L., Peterson, J., Philippen, S., Pieloth, D., Pieper, S., Pittermann, M., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Pries, B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reichherzer, P., Reimann, R., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Roberts, E. J., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Saffer, J., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schindler, S., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Schwefer, G., Sclafani, S., Seckel, D., Seunarine, S., Sharma, A., Shefali, S., Silva, M., Skrzypek, B., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Spannfellner, C., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tischbein, F., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unland Elorrieta, M. A., Valtonen-Mattila, N., Vandenbroucke, J., Eijndhoven, N., Vannerom, D., Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Watson, T. B., Weaver, C., Weigel, P., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Weyrauch, M., Whitehorn, N., Wiebusch, C. H., Williams, D. R., Wolf, M., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yu, S., Yuan, T., and Zhang, Z.
Subjects: Particle physics, Physics - Instrumentation and Detectors, neural network, Astrophysics::High Energy Astrophysical Phenomena, energy resolution, FOS: Physical sciences, Scale (descriptive set theory), GeV, 01 natural sciences, Convolutional neural network, 030218 nuclear medicine & medical imaging, IceCube Neutrino Observatory, IceCube, 03 medical and health sciences, 0302 clinical medicine, neutrino: energy, 0103 physical sciences, ddc:530, Neutrino oscillation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, oscillation [neutrino], resolution, Instrumentation and Detectors (physics.ins-det), Data set, observatory, energy [neutrino], High Energy Physics::Experiment, neutrino: oscillation, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Event (particle physics), Energy (signal processing)
Abstract: Measurements of neutrinos at and below 10 GeV provide unique constraints of neutrino oscillation parameters as well as probes of potential Non-Standard Interactions (NSI). The IceCube Neutrino Observatory's DeepCore array is designed to detect neutrinos down to GeV energies. IceCube has built the world's largest data set of neutrinos >10 GeV, making searches for NSI a computational challenge. This work describes the use of convolutional neural networks (CNNs) to improve the energy reconstruction resolution and speed of reconstructing O(10 GeV) neutrino events in IceCube. Compared to current likelihood-based methods which take seconds to minutes, the CNN is expected to provide approximately a factor of 2 improvement in energy resolution while reducing the reconstruction time per event to milliseconds, which is essential for processing large datasets., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions. 8 pages. 16 figures
Published: 2021
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16. Detection of a particle shower at the Glashow resonance with IceCube

Author: IceCube Collaboration, Aartsen, M. G., Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Bagherpour, H., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Böser, S., Botner, O., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Campana, M. A., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fedynitch, A., Fazely, A. R., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Grégoire, T., Griffith, Z., Griswold, S., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguyen, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. Pérez de los, Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Relich, M., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stürwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Wandkowsky, N., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., Zöcklein, M., and Collaboration, IceCube
Subjects: Particle physics, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, 7. Clean energy, 01 natural sciences, IceCube Neutrino Observatory, Standard Model, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Particle shower, 0103 physical sciences, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Multidisciplinary, Muon, 010308 nuclear & particles physics, Glashow resonance, High Energy Physics::Phenomenology, Astrophysics::Instrumentation and Methods for Astrophysics, Généralités, High Energy Physics::Experiment, Neutrino astronomy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, Electron neutrino
Abstract: The Glashow resonance describes the resonant formation of a W− boson during the interaction of a high-energy electron antineutrino with an electron1, peaking at an antineutrino energy of 6.3 petaelectronvolts (PeV) in the rest frame of the electron. Whereas this energy scale is out of reach for currently operating and future planned particle accelerators, natural astrophysical phenomena are expected to produce antineutrinos with energies beyond the PeV scale. Here we report the detection by the IceCube neutrino observatory of a cascade of high-energy particles (a particle shower) consistent with being created at the Glashow resonance. A shower with an energy of 6.05 ± 0.72 PeV (determined from Cherenkov radiation in the Antarctic Ice Sheet) was measured. Features consistent with the production of secondary muons in the particle shower indicate the hadronic decay of a resonant W− boson, confirm that the source is astrophysical and provide improved directional localization. The evidence of the Glashow resonance suggests the presence of electron antineutrinos in the astrophysical flux, while also providing further validation of the standard model of particle physics. Its unique signature indicates a method of distinguishing neutrinos from antineutrinos, thus providing a way to identify astronomical accelerators that produce neutrinos via hadronuclear or photohadronic interactions, with or without strong magnetic fields. As such, knowledge of both the flavour (that is, electron, muon or tau neutrinos) and charge (neutrino or antineutrino) will facilitate the advancement of neutrino astronomy., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2021
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17. IceCube Data for Neutrino Point-Source Searches Years 2008-2018

Author: IceCube Collaboration, Abbasi, R., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Amin, N. M., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Arg��elles, C., Axani, S., Bai, X., V., A. Balagopal, Barbano, A., Barwick, S. W., Bastian, B., Basu, V., Baum, V., Baur, S., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, Bellenghi, C., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., B��ser, S., Botner, O., B��ttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Campana, M. A., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., D��az-V��lez, J. C., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fischer, L., Fox, D., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghadimi, A., Glauch, T., Gl��senkamp, T., Goldschmidt, A., Gonzalez, J. G., Goswami, S., Grant, D., Gr��goire, T., Griffith, Z., Griswold, S., G��nd��z, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Minh, M. Ha, Hanson, K., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, C., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, T., Hultqvist, K., H��nnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Jonske, F., Joppe, R., Kang, D., Kang, W., Kang, X., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kin, K., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., K��pke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kovacevich, M., Kowalski, M., Krings, K., Kr��ckl, G., Kulacz, N., Kurahashi, N., Kyriacou, A., Gualda, C. Lagunas, Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczy��ska, A., Li, Y., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Ludwig, A., L��nemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mari��, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Meagher, K., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Micallef, J., Mockler, D., Moment��, G., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Naab, R., Nagai, R., Naumann, U., Necker, J., Neer, G., Nguy��n, L. V., Niederhausen, H., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Oehler, M., Olivas, A., O'Sullivan, E., Pandya, H., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Heros, C. P��rez de los, Philippen, S., Pieloth, D., Pieper, S., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Rodriguez, M. Prado, Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Renschler, M., Renzi, G., Resconi, E., Reusch, S., Rhode, W., Richman, M., Riedel, B., Robertson, S., Roellinghoff, G., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Cantu, D. Rysewyk, Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schr��der, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., St��rwald, T., Stuttard, T., Sullivan, G. W., Taboada, I., Tenholt, F., Ter-Antonyan, S., Tilav, S., Tollefson, K., Tomankova, L., T��nnis, C., Toscano, S., Tosi, D., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Twagirayezu, J. P., Ty, B., Unger, E., Elorrieta, M. A. Unland, Vandenbroucke, J., van Eijk, D., van Eijndhoven, N., Vannerom, D., van Santen, J., Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Xu, Y., Yanez, J. P., Yoshida, S., Yuan, T., Zhang, Z., and Z��cklein, M.
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), 010308 nuclear & particles physics, 0103 physical sciences, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 01 natural sciences
Abstract: IceCube has performed several all-sky searches for point-like neutrino sources using track-like events, including a recent time-integrated analysis using 10 years of IceCube data. This paper accompanies the public data release of these neutrino candidates detected by IceCube between April 6, 2008 and July 8, 2018. The selection includes through-going tracks, primarily due to muon neutrino candidates, that reach the detector from all directions, as well as neutrino track events that start within the instrumented volume. An updated selection and reconstruction for data taken after April 2012 slightly improves the sensitivity of the sample. While more than 80% of the sample overlaps between the old and new versions, differing events can lead to changes relative to the previous 7 year event selection. An a posteriori estimate of the significance of the 2014-2015 TXS flare is reported with an explanation of observed discrepancies with previous results. This public data release, which includes 10 years of data and binned detector response functions for muon neutrino signal events, shows improved sensitivity in generic time-integrated point source analyses and should be preferred over previous releases., See https://icecube.wisc.edu/science/data/PS-IC40-IC86_VII for the associated data release files. For the associated time-integrated analysis results, see Phys. Rev. Lett. 124, 051103 (2020) (also available at arXiv:1910.08488)
Published: 2021
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18. Searching for eV-scale sterile neutrinos with eight years of atmospheric neutrinos at the IceCube Neutrino Telescope

Author: Aartsen, M. G., Abbasi, R., Anderson, T., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Grégoire, T., Ansseau, I., Griffith, Z., Griswold, S., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halliday, R., Halve, L., Halzen, F., Hanson, K., Anton, G., Hardin, J., Haungs, A., Hauser, S., Hebecker, D., Heereman, D., Heix, P., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Argüelles, C., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Huber, Thomas, Auffenberg, J., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jansson, M., Japaridze, G. S., Jeong, M., Jones, B. J. P., Axani, S., Jonske, F., Joppe, R., Kang, D., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Bagherpour, H., Kauer, M., Kellermann, M., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, Thomas, Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Bai, X., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Koundal, P., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Balagopal, A., V., Kurahashi, N., Kyriacou, A., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leszczyńska, A., Li, Y., Liu, Q. R., Barbano, A., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Lucarelli, F., Ludwig, A., Lünemann, J., Luszczak, W., Lyu, Y., Ma, W. Y., Madsen, J., Ackermann, M., Barwick, S. W., Maggi, G., Mahn, K. B. M., Makino, Y., Mallik, P., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., McNally, F., Bastian, B., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Merz, J., Meures, T., Micallef, J., Mockler, D., Momenté, G., Basu, V., Montaruli, T., Moore, R. W., Morse, R., Moulai, M., Muth, P., Nagai, R., Naumann, U., Neer, G., Nguyen, L. V., Niederhausen, H., Baum, V., Nisa, M. U., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Oehler, M., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Baur, S., Pankova, D. V., Park, N., Parker, G. K., Paudel, E. N., Peiffer, P., Pérez de los Heros, C., Philippen, S., Pieloth, D., Pieper, S., Pinat, E., Bay, R., Pizzuto, A., Plum, M., Popovych, Y., Porcelli, A., Prado Rodriguez, M., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Beatty, J. J., Rauch, L., Rawlins, K., Rea, I. C., Rehman, A., Reimann, R., Relethford, B., Renschler, M., Renzi, G., Resconi, E., Rhode, W., Becker, K.-H., Richman, M., Riedel, B., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk Cantu, D., Safa, I., Sanchez Herrera, S. E., Becker Tjus, J., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Scharf, M., Schaufel, M., Schieler, H., Schlunder, P., BenZvi, S., Schmidt, T., Schneider, A., Schneider, J., Schröder, F. G., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Shefali, S., Silva, M., Adams, J., Berley, D., Smithers, B., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Bernardini, E., Stein, Robert, Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stössl, A., Strotjohann, Nora Linn, Stürwald, T., Stuttard, T., Sullivan, G. W., Besson, D. Z., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, Andrii, Tilav, S., Tollefson, K., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Binder, G., Trettin, A., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Unland Elorrieta, M. A., Usner, Marcel, Bindig, D., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., Vannerom, D., Santen, Jakob van, Verpoest, S., Vraeghe, M., Walck, C., Wallace, A., Blaufuss, E., Wallraff, M., Watson, T. B., Weaver, C., Weindl, A., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Whelan, B. J., Whitehorn, N., Blot, S., Wiebe, K., Wiebusch, C. H., Williams, D. R., Wills, L., Wolf, M., Wood, T. R., Woschnagg, K., Wrede, G., Wulff, J., Xu, X. W., Bohm, C., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Zhang, Z., Zöcklein, M., IceCube Collaboration, Böser, S., Botner, O., Aguilar, J. A., Böttcher, J., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bron, S., Brostean-Kaiser, J., Burgman, A., Buscher, J., Busse, R. S., Ahlers, M., Carver, T., Chen, C., Cheung, E., Chirkin, D., Choi, S., Clark, B. A., Clark, K., Classen, L., Coleman, A., Collin, G. H., Ahrens, M., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., Alispach, C., De Ridder, S., Desai, A., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Dharani, S., Diaz, A., Díaz-Vélez, J. C., Amin, N. M., Dujmovic, H., Dunkman, M., DuVernois, M. A., Dvorak, E., Ehrhardt, T., Eller, P., Engel, R., Evenson, P. A., Fahey, S., Fazely, A. R., Andeen, K., Fedynitch, A., Felde, J., Fienberg, A. T., Filimonov, K., Finley, C., Fox, D., Franckowiak, Anna, Friedman, E., Fritz, A., Gaisser, T. K., Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: Sterile neutrino, Physics::Instrumentation and Detectors, PROTON, sterile [neutrino], 01 natural sciences, High Energy Physics - Experiment, CROSS-SECTIONS, IceCube, Subatomär fysik, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), Astronomi, astrofysik och kosmologi, neutrino: atmosphere, Subatomic Physics, Astronomy, Astrophysics and Cosmology, detector [neutrino], Physics, oscillation [neutrino], Astrophysics::Instrumentation and Methods for Astrophysics, hep-ph, OPTICAL-PROPERTIES, neutrino: sterile, atmosphere [neutrino], mass difference [neutrino], ddc, High Energy Physics - Phenomenology, neutrino: detector, Physique des particules élémentaires, SOUTH-POLE ICE, Neutrino, data analysis method, Astrophysics::High Energy Astrophysical Phenomena, Neutrino telescope, neutrino: mass difference, FOS: Physical sciences, Context (language use), statistical analysis, 0103 physical sciences, OSCILLATIONS, conservation law, ddc:530, 010306 general physics, hep-ex, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Astronomy, neutrino: mixing angle, CONVERSION, Physics and Astronomy, LSND, RESOLUTION, High Energy Physics::Experiment, neutrino: oscillation, GLACIAL ICE, mixing angle [neutrino], experimental results
Abstract: Physical review / D D102(5), 052009 (1-32) (2020). doi:10.1103/PhysRevD.102.052009, We report in detail on searches for eV-scale sterile neutrinos, in the context of a 3+1 model, using eight years of data from the IceCube neutrino telescope. By analyzing the reconstructed energies and zenith angles of 305,735 atmospheric $\nu_\mu$ and $\bar{\nu}_\mu$ events we construct confidence intervals in two analysis spaces: $\sin^2 (2\theta_{24})$ vs. $\Delta m^2_{41}$ under the conservative assumption $\theta_{34}=0$; and $\sin^2(2\theta_{24})$ vs. $\sin^2 (2\theta_{34})$ given sufficiently large $\Delta m^2_{41}$ that fast oscillation features are unresolvable. Detailed discussions of the event selection, systematic uncertainties, and fitting procedures are presented. No strong evidence for sterile neutrinos is found, and the best-fit likelihood is consistent with the no sterile neutrino hypothesis with a p-value of 8% in the first analysis space and 19% in the second., Published by Inst.302363, Melville, NY
Published: 2020

19. Predicting vertical ground reaction force during running using novel piezoresponsive sensors and accelerometry

Author: James B. Tracy, Noelle J. Tuttle, A. Jake Merrell, Gavin Collins, Matthew K. Seeley, William F. Christensen, Parker G. Rosquist, Anton E. Bowden, David T. Fullwood, and Alyssa Evans-Pickett
Subjects: Male, medicine.medical_specialty, Adolescent, Computer science, 030209 endocrinology & metabolism, Physical Therapy, Sports Therapy and Rehabilitation, Health benefits, Accelerometer, Nanocomposites, Running, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Physical medicine and rehabilitation, Gait (human), Accelerometry, medicine, Injury risk, Humans, Orthopedics and Sports Medicine, Principal Component Analysis, Models, Statistical, Vertical ground reaction force, Biomechanics, 030229 sport sciences, Equipment Design, Biomechanical Phenomena, Female, Gait Analysis
Abstract: Running is a common exercise with numerous health benefits. Vertical ground reaction force (vGRF) influences running injury risk and running performance. Measurement of vGRF during running is now primarily constrained to a laboratory setting. The purpose of this study was to evaluate a new approach to measuring vGRF during running. This approach can be used outside of the laboratory and involves running shoes instrumented with novel piezoresponsive sensors and a standard accelerometer. Thirty-one individuals ran at three different speeds on a force-instrumented treadmill while wearing the instrumented running shoes. vGRF was predicted using data collected from the instrumented shoes, and predicted vGRF were compared to vGRF measured via the treadmill. Per cent error of the resulting predictions varied depending upon the predicted vGRF characteristic. Per cent error was relatively low for predicted vGRF impulse (2-7%), active peak vGRF (3-7%), and ground contact time (3-6%), but relatively high for predicted vGRF load rates (22-29%). These errors should decrease with future iterations of the instrumented shoes and collection of additional data from a more diverse sample. The novel technology described herein might become a feasible way to collect large amounts of vGRF data outside of the traditional biomechanics laboratory.
Published: 2020

20. A Novel Method to Characterize Walking and Running Energy Expenditure

Author: William F. Christensen, Parker G. Rosquist, Alyssa Evans, Anton E. Bowden, Steven J. Morrin, David T. Fullwood, James B. Tracy, Matthew K. Seeley, Noelle J. Tuttle, Gavin Collins, and A. Jake Merrell
Subjects: Energy expenditure, Computer science, Physical activity, Wearable computer, Instrumentation (computer programming), Treadmill, Accelerometer, Demographic data, Force sensor, Simulation
Abstract: Background: Physical activity and corresponding energy expenditure can improve health in various ways. Existing methods to directly measure energy expenditure are currently limited to laboratory settings and/or expensive instrumentation. The purpose of this study was to evaluate accuracy of energy expenditure characterization, during walking and running, using demographic data, as well as data collected via an accelerometer and novel piezoresponsive foam sensors. Methods: 30 individuals (14 females; mass = 67 ± 10 kg; height = 1.74 ± 0.08 m; age = 23 ± 3 yrs) walked and ran at five speeds (1.34, 2.23, 2.68, 3.13, and 3.58 m/s) on a force-instrumented treadmill while wearing a metabolic analyzer and standardized athletic shoes instrumented with an accelerometer, and four novel nanocomposite piezoresponsive force sensors. Various predictive models, including demographic data and data derived from the accelerometer and force sensors, were evaluated for each gait speed. Results: The predictive models varied in ability to accurately characterize energy expenditure. For walking, the most accurate model included acceleration and body weight, and resulted in an average absolute error of 0.07 ± 0.03 kcal/min. For running, the most accurate model included sensor and acceleration data, and resulted in an average absolute error of 0.45 ± 0.14 kcal/min. Conclusions: When combined with acceleration data and body weight, the novel foam sensors can be used to inexpensively and accurately measure walking and running energy expenditure. This can be done at various speeds, outside of a traditional research laboratory. These results have application within a wide range of diverse contexts.
Published: 2018

21. New intracellular activities of matrix metalloproteinases shine in the moonlight

Author: Parker G. Jobin, Christopher M. Overall, and Georgina S. Butler
Subjects: 0301 basic medicine, Protein moonlighting, Proteases, Cell Biology, Biology, Matrix metalloproteinase, Subcellular localization, Matrix Metalloproteinases, Extracellular Matrix, Cell biology, Extracellular matrix, 03 medical and health sciences, 030104 developmental biology, Proteolysis, Extracellular, Animals, Cytokines, Humans, Signal transduction, Protein Processing, Post-Translational, Molecular Biology, Intracellular, Signal Transduction
Abstract: Adaption of a single protein to perform multiple independent functions facilitates functional plasticity of the proteome allowing a limited number of protein-coding genes to perform a multitude of cellular processes. Multifunctionality is achievable by post-translational modifications and by modulating subcellular localization. Matrix metalloproteinases (MMPs), classically viewed as degraders of the extracellular matrix (ECM) responsible for matrix protein turnover, are more recently recognized as regulators of a range of extracellular bioactive molecules including chemokines, cytokines, and their binders. However, growing evidence has convincingly identified select MMPs in intracellular compartments with unexpected physiological and pathological roles. Intracellular MMPs have both proteolytic and non-proteolytic functions, including signal transduction and transcription factor activity thereby challenging their traditional designation as extracellular proteases. This review highlights current knowledge of subcellular location and activity of these “moonlighting” MMPs. Intracellular roles herald a new era of MMP research, rejuvenating interest in targeting these proteases in therapeutic strategies. This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman.
Published: 2017

22. Estimation of 3D Ground Reaction Force Using Nanocomposite Piezo-Responsive Foam Sensors During Walking

Author: William F. Christensen, Parker G. Rosquist, Matthew K. Seeley, James B. Tracy, Noelle J. Tuttle, Gavin Collins, A. Jake Merrell, David T. Fullwood, Evan T. Bird, and Anton E. Bowden
Subjects: Adult, Male, 0206 medical engineering, Biomedical Engineering, Walking, 02 engineering and technology, Models, Biological, Cross-validation, Nanocomposites, 03 medical and health sciences, 0302 clinical medicine, Calibration, Humans, Treadmill, Ground reaction force, Gait, Simulation, Mathematics, Biomechanics, 020601 biomedical engineering, Data set, Gait analysis, Female, 030217 neurology & neurosurgery, Arithmetic mean, Biomedical engineering
Abstract: This paper describes a method for the estimation of the 3D ground reaction force (GRF) during human walking using novel nanocomposite piezo-responsive foam (NCPF) sensors. Nine subjects (5 male, 4 female) walked on a force-instrumented treadmill at 1.34 m/s for 120 s each while wearing a shoe that was instrumented with four NCPF sensors. GRF data, measured via the treadmill, and sensor data, measured via the NCPF inserts, were used in a tenfold cross validation process to calibrate a separate model for each individual. The calibration model estimated average anterior-posterior, mediolateral and vertical GRF with mean average errors (MAE) of 6.52 N (2.14%), 4.79 N (6.34%), and 15.4 N (2.15%), respectively. Two additional models were created using the sensor data from all subjects and subject demographics. A tenfold cross validation process for this combined data set resulted in models that estimated average anterior-posterior, mediolateral and vertical GRF with less than 8.16 N (2.41%), 6.63 N (7.37%), and 19.4 N (2.31%) errors, respectively. Intra-subject estimates based on the model had a higher accuracy than inter-subject estimates, likely due to the relatively small subject cohort used in creating the model. The novel NCPF sensors demonstrate the ability to accurately estimate 3D GRF during human movement outside of the traditional biomechanics laboratory setting.
Published: 2017

23. An Eyebrow, Supracarotid Triangle Approach for Lesions at the Ventral Thalamopeduncular Junction: A Technical Report

Author: Parker G. Allan, Andrew K. Conner, Robert G. Briggs, Charles Teo, Isabella M. Young, Michael E. Sughrue, and Arpan R. Chakraborty
Subjects: Adult, Male, medicine.medical_specialty, Cerebral Peduncle, medicine.medical_treatment, Eyebrow, Astrocytoma, Complete resection, Resection, Lesion, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Thalamus, medicine, Brain Stem Neoplasms, Humans, Craniotomy, Retrospective Studies, Pilocytic astrocytoma, business.industry, Cerebral peduncle, Critical question, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Surgery, Female, Neurology (clinical), Radiology, medicine.symptom, Eyebrows, business, 030217 neurology & neurosurgery
Abstract: Background Lesions arising at the ventral thalamopeduncular junction are difficult to resect. In addition to being relatively inaccessible, these lesions are located in one of the most sensitive areas of the brain. A critical question is whether new approaches could be developed to allow surgeons to adequately resect these lesions with reasonable outcomes. In the present report, we describe our approach to resect lesions in this region of the brain using an eyebrow craniotomy approach with a trajectory through the supracarotid triangle. Methods Through retrospective data collection, we present a small series of patients who had undergone an eyebrow, supracarotid triangle approach to resect lesions located at the thalamopeduncular junction. We describe our surgical technique and report patient outcomes using this approach. Results Three patients had undergone an eyebrow, supracarotid approach for resection of a lesion arising at the ventral thalamopeduncular junction. Two patients had presented with a cavernoma and one with a pilocytic astrocytoma. Complete resection of all 3 lesions was achieved during surgery without any intraoperative complications. No patient developed permanent contralateral weakness despite entering the peduncle during surgery. One patient developed permanent paresthesia in his left hand. Conclusions Lesions arising at the ventral thalamopeduncular junction can be adequately resected with reasonable outcomes using an eyebrow, supracarotid triangle approach. This operative technique establishes another potential operative corridor by which neurosurgeons can resect lesions arising within this relatively inaccessible part of the brain.
Published: 2019

24. Parcellation-based tractographic modeling of the ventral attention network

Author: Chad A. Glenn, Andrew K. Conner, Joshua D. Burks, Goksel Sali, Robert G. Briggs, Phillip A. Bonney, Michael E. Sughrue, Christen M. O'Neal, Parker G. Allan, Cordell M Baker, and B. David Maxwell
Subjects: Anterior insula, Brain Mapping, Future studies, Computer science, Fiber tractography, Activation likelihood estimation, Inferior parietal lobule, Network connectivity, Magnetic Resonance Imaging, 03 medical and health sciences, 0302 clinical medicine, Diffusion Tensor Imaging, Neurology, Attention network, Humans, Attention, 030212 general & internal medicine, Neurology (clinical), Nerve Net, Neuroscience, Cerebrum, 030217 neurology & neurosurgery, Tractography
Abstract: Introduction The ventral attention network (VAN) is an important mediator of stimulus-driven attention. Multiple cortical areas, such as the middle and inferior frontal gyri, anterior insula, inferior parietal lobule, and temporo-parietal junction have been linked in this processing. However, knowledge of network connectivity has been devoid of structural specificity. Methods Using relevant task-based fMRI studies, an activation likelihood estimation (ALE) of the VAN was generated Regions of interest corresponding to the HCP cortical parcellation scheme were co-registered onto this ALE in MNI coordinate space and visually assessed for inclusion in the network. DSI-based fiber tractography was performed to determine the structural connections between cortical areas comprising the VAN. Results Fourteen regions within the right cerebral hemisphere were found to overlap the ALE of the VAN: 6a, 6r, 7AM, 7PM, 8C, AVI, FOP4, MIP, p9-46v, PCV, PFm, PGi, TPOJ1, and TPOJ2. Regions demonstrated consistent U-shaped interconnections between adjacent parcellations, and the SLF was found to connect frontal and parietal areas of the network. Conclusions We present a tractographic model of the VAN. This model comprises parcellations within the frontal and parietal cortices that are linked via the SLF. Future studies may refine this model with the ultimate goal of clinical application.
Published: 2019

25. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase

Author: Georgina S. Butler, Yoan Machado, Nam Hoon Kwon, Christopher M. Overall, Parker G. Jobin, Sunghoon Kim, Nestor Solis, and Peter A. Bell
Subjects: 0301 basic medicine, proteolysis, Biochemistry & Molecular Biology, matrix metalloproteinase, Cells, Tryptophan-tRNA Ligase, macrophage, Biochemistry, Medical and Health Sciences, Proinflammatory cytokine, 03 medical and health sciences, Interferon-gamma, Interferon, multifunctional protein, medicine, Humans, Editors' Picks, Secretion, Interleukin 8, Molecular Biology, innate immunity, Cells, Cultured, Inflammation, Cultured, 030102 biochemistry & molecular biology, Chemistry, Monocyte, Macrophages, aminoacyl tRNA synthetase, Endothelial Cells, Cell Biology, interferon, Fibroblasts, Biological Sciences, Matrix Metalloproteinases, Cell biology, TLR2, 030104 developmental biology, medicine.anatomical_structure, monocyte, Chemical Sciences, Phosphorylation, toll-like receptor, Tumor necrosis factor alpha, medicine.drug
Abstract: Tryptophanyl-tRNA synthetase (WRS) is a cytosolic aminoacyl-tRNA synthetase essential for protein synthesis. WRS is also one of a growing number of intracellular proteins that are attributed distinct noncanonical “moonlighting” functions in the extracellular milieu. Moonlighting aminoacyl-tRNA synthetases regulate processes such as inflammation, but how these multifunctional enzymes are themselves regulated remains unclear. Here, we demonstrate that WRS is secreted from human macrophages, fibroblasts, and endothelial cells in response to the proinflammatory cytokine interferon γ (IFNγ). WRS signaled primarily through Toll-like receptor 2 (TLR2) in macrophages, leading to phosphorylation of the p65 subunit of NF-κB with associated loss of NF-κB inhibitor α (IκB-α) protein. This signaling initiated secretion of tumor necrosis factor α (TNFα) and CXCL8 (IL8) from macrophages. We also demonstrated that WRS is a potent monocyte chemoattractant. Of note, WRS increased matrix metalloproteinase (MMP) activity in the conditioned medium of macrophages in a TNFα-dependent manner. Using purified recombinant proteins and LC-MS/MS to identify proteolytic cleavage sites, we demonstrated that multiple MMPs, but primarily macrophage MMP7 and neutrophil MMP8, cleave secreted WRS at several sites. Loss of the WHEP domain following cleavage at Met(48) generated a WRS proteoform that also results from alternative splicing, designated Δ1–47 WRS. The MMP-cleaved WRS lacked TLR signaling and proinflammatory activities. Thus, our results suggest that moonlighting WRS promotes IFNγ proinflammatory activities, and these responses can be dampened by MMPs.
Published: 2019

26. Cost Effective Videography for Modern Anatomy Education

Author: Jennifer Dennis, Parker G Adams, Colin Farritor, and Gregory G Motzkus
Subjects: Medical education, education, Human anatomy, Genetics, Subject (philosophy), Medical school, Student learning, Videography, Anatomy education, Psychology, Molecular Biology, Biochemistry, Biotechnology
Abstract: Human Anatomy is a hallmark subject of medical school and often presents a significant challenge for student learning. Classic anatomical instruction relies on significant time completing cadaveric...
Published: 2019

27. Exergy Analysis of Ship Power Systems

Author: Parker, G G, Trinklein, E H, Robinett III, R D, and McCoy, T J
Subjects: Control, Pulsed Load, Exergy, Energy Storage
Abstract: Ship subsystems and mission modules perform energy conversion during their operation resulting in a combination of electricity consumption, heat generation and mechanical work. These multi-physics subsystems often have opportunities for performing an energy storage role during their operation cycle. The kinetic energy stored in the rotating mass of a generator set or the electrical energy stored in a railgun pulse forming network are but two examples of energy storage aboard warships. Treating each subsystem as a disconnected entity reduces the potential for exploiting their inherent interactions and results in over-designed shipboard systems with excessive weight and volume. Exergy - the amount of energy available for performing useful work - provides a path for exploiting multi-physics energy flows. Utilizing the Second Law of Thermodynamics, by modeling and minimizing exergy destruction, a recent study, showed that exergy control increased the overall efficiency by 18% over traditional optimization techniques when applied to a terrestrial HVAC application. In this paper a notional, multi-physics ship power system is developed that explicitly captures the exergy flows. Particular attention is given to exergy destruction phenomena. Simulation of the system illustrates operational characteristics with greatest impact on exergy destruction highlighting areas for applying optimal, exergy-based control schemes. This approach will allow ship designers to minimize the size and weight of installed power generation, energy storage and thermal management systems, enabling the affordable implementation of advanced weapons and sensors.&nbsp
Published: 2018

28. Epstein-Barr Virus (EBV) nuclear antigen 3C inhibits expression of COBLL1 and the ADAM28-ADAMDEC1 locus via interaction with the histone lysine demethylase KDM2B

Author: Gillman, ACT, Parker, G, Allday, MJ, Bazot, Q, Sandri-Goldin, R, and Wellcome Trust
Subjects: Chromatin Immunoprecipitation, Jumonji Domain-Containing Histone Demethylases, PRC1 COMPLEX, Gene Expression, BINDING PROTEIN, Histones, KDM2B, Virology, 07 Agricultural and Veterinary Sciences, Epstein-Barr virus, Humans, transcriptional regulation, CRYSTAL-STRUCTURE, TUMOR-SUPPRESSOR, H2A UBIQUITYLATION, Cells, Cultured, 11 Medical and Health Sciences, BURKITTS-LYMPHOMA, Polycomb Repressive Complex 1, B-Lymphocytes, Science & Technology, EBNA3, REPRESSIVE COMPLEX 1, histone modifications, F-Box Proteins, RBP-J-KAPPA, Polycomb Repressive Complex 2, 06 Biological Sciences, NOTCH-RAM-REGION, ADAM Proteins, Epstein-Barr Virus Nuclear Antigens, Immunoglobulin J Recombination Signal Sequence-Binding Protein, LYMPHOBLASTOID CELL-GROWTH, Life Sciences & Biomedicine, Transcription Factors
Abstract: Epstein-Barr virus nuclear antigen 3C (EBNA3C) is a well-defined repressor of host gene expression in B cells transformed by Epstein-Barr virus (EBV) that cooperates with various cellular factors. It is established that EBNA3C interacts with the cellular factor RBPJ (RBP-Jκ or CBF1) through two distinct motifs: the TFGC motif, also called the homology domain (HD) motif, and the VWTP motif. In this study, we investigated the role of each motif in EBNA3C transcriptional repression activity by using two novel recombinant viruses with single RBPJ interaction motifs mutated (EBNA3C HDmut and EBNA3C W227S). Infection of primary B cells with either of these recombinant EBVs led to the successful establishment of lymphoblastoid cell lines (LCLs). Gene expression analysis showed that full repression of EBNA3C target genes is not achieved by EBNA3C HDmut compared to that with EBNA3C W227S or the EBNA3C wild type (WT). Focusing on the well-characterized EBNA3C-repressed genes COBLL1, ADAM28, and ADAMDEC1, we investigated the mechanism of EBNA3C-mediated transcriptional repression. Chromatin immunoprecipitation (ChIP) analysis indicated that EBNA3C HDmut is still able to recruit Polycomb proteins BMI1 and SUZ12 to COBLL1 as efficiently as EBNA3C WT does, leading to the full deposition of the repressive histone mark H3K27me3. However, we found that the activation-associated chromatin mark H3K4me3 is highly enriched at EBNA3C target genes in LCLs expressing EBNA3C HDmut. We show here that EBNA3C interacts with the histone lysine demethylase KDM2B and that this interaction is important for H3K4me3 removal and for the EBNA3C-mediated repression of COBLL1 and the ADAM28-ADAMDEC1 locus. IMPORTANCE EBV is a virus associated with human cancers and is well known for its ability to transform B lymphocytes into continuously proliferating lymphoblastoid cell lines. EBNA3C is considered an oncoprotein and has been shown to be essential for B cell transformation by EBV. EBNA3C is well characterized as a viral transcription factor, but very little is known about its mechanisms of action. In the present study, we demonstrate that removal of the activating histone mark H3K4me3 and deposition of the repressive mark H3K27me3 by EBNA3C on COBLL1 are achieved by at least two distinct mechanisms. Furthermore, we discovered that EBNA3C interacts with the lysine demethylase KDM2B and that this interaction is important for its transcriptional repressive function. The findings in this study provide new insights into the mechanism used by the oncoprotein EBNA3C to repress cellular target genes.
Published: 2018

29. The RA-MAP Consortium: a working model for academia-industry collaboration

Author: Cope, AP, Barnes, MR, Belson, A, Binks, M, Brockbank, S, Bonachela-Capdevila, F, Carini, C, Fisher, BA, Goodyear, CS, Emery, P, Ehrenstein, MR, Gozzard, N, Harris, R, Hollis, S, Keidel, S, Levesque, M, Lindholm, C, McDermott, MF, McInnes, IB, Mela, CM, Parker, G, Read, S, Pedersen, AW, Ponchel, F, Porter, D, Rao, R, Rowe, A, Schulz-Knappe, P, Sleeman, MA, Symmons, D, Taylor, PC, Tom, B, Tsuji, W, Verbeeck, D, Isaacs, JD, Consortium, Ra-Map, Tom, Brian [0000-0002-3335-9322], and Apollo - University of Cambridge Repository
Subjects: 0301 basic medicine, Biomedical Research, Big data, MEDLINE, Globe, History, 21st Century, Article, Arthritis, Rheumatoid, 03 medical and health sciences, Rheumatology, medicine, Genomic medicine, Humans, Industry, Cooperative Behavior, business.industry, Research, Genomics, Public relations, United Kingdom, 030104 developmental biology, medicine.anatomical_structure, Phenotype, Cooperative behavior, business, Biomarkers
Abstract: Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing and fostering new research consortia. This model has percolated down to national funding agencies across the globe, leading to funding for projects that aim to realise the true potential of genomic medicine in the 21st century and to reap the rewards of ‘big data’. In this Perspectives article, the experiences of the RA-MAP consortium, a group of more than 140 individuals affiliated with 21 academic and industry organizations that are focused on making genomic medicine in rheumatoid arthritis a reality are described. The challenges of multi-partner collaboration in the UK are highlighted and wide-ranging solutions are offered that might benefit large research consortia around the world.
Published: 2018
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30. Religion et transition énergétique : une étude en Amérique du Sud

Author: Cristián Parker G
Subjects: Consumption (economics), Definition of religion, Latin Americans, Sociology and Political Science, Forms of energy, Religious studies, Energy transition, Religiosity, Economy, Anthropology, Global citizenship, Sociology, Social science, Efficient energy use
Abstract: Global society’s goal is to transition to more sustainable forms of energy production and consumption. How is the religious factor supporting this transition to sustainable energy models and renewable energy? This is a question that social scientists are only just beginning to respond to. In Latin America, it has hardly been raised. This article is an effort to answer this question, taking into account the complex nature of the definition of religion and religiosity. Building on a mixed methodology, the author analyses a national survey of Chilean university students. He observes the relationship between religiosity or declared religious choice and certain aspects of the energy transition – energy efficiency, renewable energy and social patterns of sustainable energy consumption – and finds that religion does play a role, but that this is heterogeneous: many trends indicate that Catholics, evangelicals and members of missionary churches do not support the energy transition, while non-believers do, but the trends are weak. The author analyses these and other trends, ponders their meanings and provides an interpretation and typology. His interpretation points to the need for further study of the relationship between religion and changing lifestyles towards more sustainable forms of energy.
Published: 2015

31. Changement climatique, transition énergétique et religions/Climate change, energy transition and religions

Author: Cristián Parker G
Subjects: Sociology and Political Science, Anthropology, Political science, Religious studies
Published: 2015

32. Age-based morphodynamic formulation for streamwise and vertical advection and dispersion of tracer particles in rivers

Author: Pelosi, A., Schumer, R., Ma, H., and Parker, G.
Published: 2017

33. Optimization of a Graded Multi-Material Composite Flywheel

Author: Newton, Cory, Crampton, Erica B., and Rosquist, Parker G.
Abstract: Storing energy is a challenge given the fleeting nature of elemental energy. Flywheels were developed to solve this problem of energy storage by transferring unused energy into controlled rotational motion with the ability to transfer it back into usable energy. Flywheel design has evolved significantly and the most sophisticated and expensive flywheels incorporate composite materials. This paper introduces a novel multi-objective approach to flywheel design where composite materials are optimally mixed together to produce the maximum amount of rotational energy while minimizing the cost for production. To determine the best mixture of materials, coefficients for a polynomial model describing this mixture are treated as design variables. This model is then optimized for every combination of fiber materials over a range of cost constraints, resulting in a Pareto front of optimal material combinations. This Pareto front provides insight into cost versus performance trends for a graded multi-material flywheel and can be used as a decision making tool for industries in flywheel design.
Published: 2016
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34. Effect of environmental and material factors on the response of nanocomposite foam impact sensors

Author: David T. Fullwood, Adin Martineau, Anton E. Bowden, Jake Merrell, Evan T. Bird, Matthew K. Seeley, and Parker G. Rosquist
Subjects: 010302 applied physics, Nanocomposite, Materials science, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, Mechanics of Materials, 0103 physical sciences, Signal Processing, General Materials Science, Electrical and Electronic Engineering, Composite material, 0210 nano-technology, Civil and Structural Engineering
Published: 2018

35. Inclusión laboral de personas en situación de discapacidad intelectual egresadas del programa diploma en habilidades laborales de la Universidad Andrés Bello: perspectiva de empleadores

Author: Daniela Navarro O., María Fernanda Ordenes S., Josefina Blanch M., and María Victoria Parker G.
Subjects: General Medicine
Abstract: Este artículo pretende rescatar —a través de una metodología mixta de investigación— la experiencia de empleadores que brindan oportunidades de trabajo en sus empresas a personas en situación de discapacidad intelectual egresadas, desde el año 2007, del Programa Diploma en Habilidades Laborales de la Universidad Andrés Bello. El objetivo es identificar las habilidades y competencias que les han permitido insertarse en el medio laboral y la incidencia que ha tenido, desde su perspectiva, la formación socio laboral recibida. Junto con esto, el artículo recoge sus valoraciones respecto a la inclusión laboral de jóvenes con discapacidad en sus empresas, identificando los aportes y dificultades que este proceso ha representado para ellos. En general, se pudo observar una valoración positiva de los empleadores hacia la inclusión laboral de personas en situación de discapacidad intelectual en sus empresas. Así, concordaron en que éstas cuentan con las habilidades para desempeñarse adecuadamente en el cargo, a la vez que establecen relaciones interpersonales favorables con el resto de empleados.
Published: 2017

36. Mobile, Low Profile, and Inexpensive Knee Joint Angle Sensor

Author: Anton E. Bowden, Adin Martineau, Parker G. Rosquist, Dustin A. Bruening, Matthew K. Seeley, Gavin Collins, David T. Fullwood, and James B. Tracy
Subjects: Computer science, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Knee Joint, Simulation
Published: 2017

37. The CONNECT project: Combining macro- and micro-structure

Author: Assaf, Y., Alexander, D., Jones, D., Bizzi, A., Behrens, T., Clark, C., Cohen, Y., Dyrby, T., Huppi, P., Knösche, T., LeBihan, D., Parker, G., Poupon, C., Anaby, D., Anwander, A., Bar, L., Barazany, D., Blumenfeld-Katzir, T., De-Santis, S., Duclap, D., Figini, M., Fischi, E., Guevara, P., Hubbard, P., Hofstetter, S., Jbabdi, S., Kunz, N., Lazeyras, F., Lebois, A., Liptrot, M., Lundell, H., Mangin, J., Moreno-Dominguez, D., Morozov, D., Schreiber, J., Seunarine, K., Nava, S., Riffert, T., Sasson, E., Schmitt, B., Shemesh, N., Sotiropoulos, S., Tavora, I., Zhang, H., Zhou, F., and Lazeyras, François
Subjects: Models, Anatomic, ddc:618, Brain/cytology/physiology, Connectome/methods, Models, Neurological, Brain, Image Enhancement, Diffusion Tensor Imaging, Diffusion Tensor Imaging/methods, Connectome, Humans, Image Enhancement/methods, Nerve Net, Nerve Net/cytology/physiology
Abstract: In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.
Published: 2013

38. No measurable changes in (238)U/(235)U due to desorption-adsorption of U(VI) from groundwater at the Rifle, Colorado, integrated field research challenge site

Author: Philip E. Long, Parker G. Laubach, Alyssa E. Shiel, Craig C. Lundstrom, Kenneth H. Williams, and Thomas M. Johnson
Subjects: Geologic Sediments, Water Pollutants, Radioactive, Colorado, Chemistry, chemistry.chemical_element, General Chemistry, Fractionation, Contamination, Uranium, Isotopic composition, Pore water pressure, Bicarbonates, Adsorption, Environmental chemistry, Desorption, Environmental Chemistry, Groundwater
Abstract: Groundwater samples were collected from the Integrated Field Research Challenge field site in Rifle, Colorado, over the course of a bicarbonate-induced U desorption-adsorption experiment. Uranium concentrations and high precision U isotopic compositions ((238)U/(235)U) of these groundwater samples were determined and used to assess the impact of bicarbonate-induced U(VI) desorption from contaminated sediments on the (238)U/(235)U of groundwater. The (238)U/(235)U of groundwater was not significantly impacted by bicarbonate-induced desorption of U(VI) from mineral surfaces or by adsorption of advecting U(VI) from upgradient locations onto those surfaces after the treatment. Assuming this absence of a significant shift in U isotopic composition associated with desorption-adsorption applies to other systems, reduction of U(VI) to U(IV) is expected to be the dominant source of U isotopic fractionation associated with removal of U(VI) from pore water as a result of natural and stimulated reductive pathways. Thus, changes in the (238)U/(235)U composition of uranium-bearing fluids should be useful in quantifying the extent of reduction.
Published: 2013

39. Vibration monitoring via nano-composite piezoelectric foam bushings

Author: Brady Anderson, Parker G. Rosquist, Matthew K. Seeley, Cory Nelson Newton, David T. Fullwood, Evan T. Bird, A. Jake Merrell, and Anton E. Bowden
Subjects: Engineering, Acoustics, 02 engineering and technology, 01 natural sciences, Signal, 0103 physical sciences, Nano, General Materials Science, Electrical and Electronic Engineering, 010301 acoustics, Electrical conductor, Civil and Structural Engineering, business.industry, Structural engineering, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Piezoelectricity, Atomic and Molecular Physics, and Optics, Mechanical system, Vibration, Mechanics of Materials, Bushing, Signal Processing, Electric power, 0210 nano-technology, business
Abstract: Most mechanical systems produce vibrations as an inherent side effect of operation. Though some vibrations are acceptable in operation, others can cause damage or signal a machine's imminent failure. These vibrations would optimally be monitored in real-time, without human supervision to prevent failure and excessive wear in machinery. This paper explores a new alternative to currently-used machine-monitoring equipment, namely a piezoelectric foam sensor system. These sensors are made of a silicone-based foam embedded with nano- and micro-scale conductive particles. Upon impact, they emit an electric response that is directly correlated with impact energy, with no electrical power input. In the present work, we investigated their utility as self-sensing bushings on machinery. These sensors were found to accurately detect both the amplitude and frequency of typical machine vibrations. The bushings could potentially save time and money over other vibration sensing mechanisms, while simultaneously providing a potential control input that could be utilized for correcting vibrational imbalance.
Published: 2016

40. Modeling 3D Ground Reaction Forces During Walking Using Nanocomposite Piezo-Responsive Foam Sensors

Author: Matthew K. Seeley, David T. Fullwood, Gavin Collins, Anton E. Bowden, Jake Merrell A, Parker G. Rosquist, and Christensen Wf
Subjects: Nanocomposite, Materials science, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Composite material, Ground reaction force
Published: 2016

41. Las dos culturas: Ciencias Naturales y Ciencias Humanas en el siglo XXI1

Author: Cristián Parker G
Subjects: lcsh:Sociology (General), lcsh:GN1-890, tecnologia, Mentalidad universitarios, lcsh:Anthropology, lcsh:HM401-1281, Pharmacology (medical), ciencias experimentales, humanidades, concepciones de la ciencia
Abstract: El articulo examina la concepción que los estudiantes universitarios chilenos tienen acerca de sus representaciones y valoraciones de las ciencias, la tecnologia y la ética. Se sistematizan los principales resultados de las encuestas realizadas entre 2005 v 2008. en el marco de proyectos FONDECYT la primera a una muestra representativa de 6.219 estudiantes de todas las universidades del Consejo de Rectores y la segunda, a una muestra de 421 estudiantes representativa de tres universidades estatales: Universidad de chile. Universidad de Concepción y Universidad de Santiago de Chile. se interroga precisamente acerca del grado en que está presente, en la mentalidad estudiantil, la distinción entre ciencias lógico-experimentales y arte-humanidades. Se entregan algunos resultados preliminares acerca de la forma de semantización de ciencia y tecnologia en estudiantes de carreras en los polos extremos: carreras tecnológicas, por una parte, y carraros de humanidades, por otra.
Published: 2012

42. On the evaluation of sediment transport in gravel-bed rivers with alternate bars

Author: Francalanci, S., Solari, L., Toffolon, M., and Parker, G.
Published: 2012

43. A Model to Predict the Evolution of a Gravel Bed River Under an Imposed Cyclic Hydrograph and its Application to the Trinity River

Author: Viparelli, E., Gaeuman, D., Wilcock, Peter, and Parker, G.
Subjects: Evolution, cyclic hydrograph, gravel bed river, Trinity River
Abstract: Major changes in the morphology of the Trinity River in California, such as narrowing of the cross section and sedimentation of fine sediment in pools, occurred after the closure of a system of dams. These changes caused a dramatic reduction in the salmonid population and a resulting decline of the fishery. Gravel augmentation, regulated flood releases, and mechanical channel rehabilitation are currently being implemented to help restore the aquatic habitat of the river. The present paper describes a tool, named the Spawning Gravel Refresher, for designing and predicting the effects of gravel augmentation in gravel bed rivers. The tool assumes an imposed, cycled hydrograph. The model is calibrated and applied to the regulated reach of the Trinity River in four steps: (1) zeroing runs to reproduce conditions of mobile bed equilibrium as best can be estimated for the predam Trinity River, (2) runs to compare the predictions with the results of previous studies, (3) runs at an engineering time scale to reproduce the effects of the dams, and (4) runs to design gravel augmentation schemes. In the fourth group of runs, the combined effects of engineered flood flow releases and gravel augmentation are predicted. At an engineering time scale, the model indicates that the fraction of fine sediment in the surface layer and in the topmost part of the substrate should decrease when subjected to these two restoration measures, with a consequent improvement of the quality of the spawning gravel.
Published: 2011

44. Hedging Variable Annuities

Author: Orlando A. and Parker G.
Published: 2011

45. Indagine sperimentale sul trasporto e deposito di materiale con granulometria uniforme e diversa densità

Author: Eviparelli, E.Viparelli, Lsolari, L.Solari, and Parker, G.
Subjects: trasporto solido
Published: 2010

46. Self-accelerating turbidity currents at laboratory scale

Author: Hajime Naruse, Sequeiros, O., Garcia, M. H., Parker, G., Endo, N., Kataoka, K. S., Yokokawa, M., and Muto, T.
Published: 2007

47. Physically-based model of downstream fining in bedrock streams with side input and verification with field data

Author: Chatanantavet, P., Parker, G., Eric Lajeunesse, Planton, P., and Valla, P.
Published: 2007

48. Human-Elephant Conflict Mitigation: A Training Course for Community-Based Approaches in Africa. Elephant Pepper Development Trust, Livingstone, Zambia and IUCN/SSC AfESG, Nairobi, Kenya. TRAINERS MANUAL

Author: E, Parker G., Osborn F., V., Hoare R., E., and Niskanen L., S.
Published: 2007
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49. Numerical analysis of alternating bars in straight channels

Author: Schielen, Ralph Mathias Johannes, van Leeuwen, Thomas, Zegeling, P.A., Parker, G., and Garcia, M.H.
Subjects: METIS-230484
Published: 2006

50. Dynamics of sand sedimentation resulting from turbidity currents caused by explosive submarine volcanic eruptions

Author: Cantelli, A., Parker, G., Johnson, S., James Daniel Lee White, and Yu, B.
Published: 2006

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