1. Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets
- Author
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Jacob Tveiten Bjerrum, Yulan Wang, Jingtao Zhang, Lene Buhl Riis, Ole Haagen Nielsen, Jakob Benedict Seidelin, Lee Kong Chian School of Medicine (LKCMedicine), and Singapore Phenome Centre
- Subjects
Wound Healing ,Inflammatory Bowel Disease ,Cell Biology ,Lipids ,Applied Microbiology and Biotechnology ,Cross-Sectional Studies ,Lipidomics ,Prostaglandins ,Humans ,Eicosanoids ,Colitis, Ulcerative ,Medicine [Science] ,Intestinal Mucosa ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Developmental Biology - Abstract
Improving the long-term prognosis of ulcerative colitis (UC) requires sustained deep mucosal colonic healing with histologic remission, making the study of colonic tissue regeneration essential. In experimental colitis models, lipid metabolites are recognized as pivotal components of this process. This study aimed to describe the kinetics of wound healing and lipid metabolites engaged in regeneration in the normal colonic mucosa and how they are affected in UC to reveal new therapeutic targets. Experimental colonic wounds were created endoscopically in quiescent UC (n=21) and controls (n=9), and the healing process was surveilled by serial endoscopies and cross-sectional wound biopsies post-wounding. Biopsies were analyzed by liquid chromatography coupled with mass spectrometry. Endoscopic wound scores were significantly higher in UC at day two (p=0.001) and seven (p
- Published
- 2022