958 results on '"O31"'
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2. O31 Dysregulated gut microbiota-host metabolism underpins immune activation in a microbiota-dependent model of ulcerative colitis
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Zhigang Liu, Jonathan Lo, James Alexander, Demenico Cozzetto, and Nick Powell
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- 2022
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Catalog
3. O31: Risk allele evidence curation, classification, and reporting: Recommendations from the ClinGen Low Penetrance/Risk Allele Working Group*
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Matthew Lebo, Marcie Steeves, Katherine Benson, Laura Conlin, Mythily Ganapathi, Vaidehi Jobanputra, Minjie Luo, Deqiong Ma, Kelly McGoldrick, Blake Palculict, Heidi Rehm, Panagiotis Sergouniotis, Samantha Schilit, Pinar Bayrak-Toydemir, Tatiana Tvrdik, Nicholas Watkins, Lauren Zec, Wenying Zhang Zhang, and Ryan Schmidt more...
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- 2023
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4. O31 Undernutrition in lactating goats at mid lactation; effect of glucogenic and ketogenic diet on negative energy balance
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C. Fernández, A. Hernández, and J. Gomis-Tena
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- 2022
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5. O31 SUTURE OR MESH REPAIR FOR THE SMALLEST UMBILICAL HERNIAS: A NATIONWIDE DATABASE STUDY
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Nadia Henriksen, Frederik Helgstrand, Thue Bisgaard, and Kristian K. Jensen
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medicine.medical_specialty ,Mesh repair ,Suture (anatomy) ,business.industry ,Nationwide database ,medicine ,Surgery ,business - Abstract
Aim High level evidence recommends the use of mesh for umbilical hernias with defects >1 cm to reduce recurrence rates without increasing the risk of postoperative complications. For umbilical hernias with defect width ≤1 cm, the literature is sparse. The aim of the study was to assess outcomes after suture and mesh repair of umbilical hernias with defect width Material and Methods By merging data from the Danish Hernia Database and the National Patients Registry from January 2007 until December 2018, patients receiving elective repair of an umbilical hernia with defect width ≤1 cm were identified. Available data included details about comorbidity, surgical technique, 90-days readmission, 90-days reoperation and reoperation for recurrence. Results A total of 7,849 patients were included, of whom 25.7% (2,013/7,849) underwent mesh repair. The cumulative 5-year incidence of reoperation for recurrence was significantly decreased after mesh repair 3.1% (95% C.I. 2.1-4.1) compared with suture repair 6.7% (95% C.I. 6.0-7.4), P Conclusions Even for the smallest umbilical hernias, mesh repair significantly decreased the recurrence rate. Onlay mesh repair was associated with the lowest risk of recurrence without increasing early complications. more...
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- 2021
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6. O31 Giant cell arteritis - a rare ocular presentation
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Periyasamy Kumar, Priti Kulkarni, Shireen Shaffu, Arumugam Moorthy, and Bharat Kapoor
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Pathology ,medicine.medical_specialty ,genetic structures ,business.industry ,The Eye in Rheumatic Disease ,Amaurosis fugax ,medicine.disease ,eye diseases ,Oral Abstract Presentations ,Jaw claudication ,Giant cell arteritis ,Rheumatology ,medicine ,Central retinal artery occlusion ,Posterior ischemic optic neuropathy ,Anterior ischemic optic neuropathy ,sense organs ,medicine.symptom ,Presentation (obstetrics) ,AcademicSubjects/MED00010 ,business ,Systemic vasculitis - Abstract
Case report - Introduction Giant cell arteritis (GCA) is a systemic vasculitis primarily affecting large- and medium-sized arteries. Classic symptoms include headache, scalp tenderness, jaw claudication and visual disturbances. Ophthalmic artery involvement commonly causes anterior ischaemic optic neuropathy. Uncommon ocular features include anterior segment ischaemia, hypotony, tonic pupil or rarely choroidal ischaemia. Heterogenicity of presentation can make diagnosis difficult leading irreversible visual loss. We report a case of bilateral macular choroidal ischaemia with atypical symptoms of GCA. It emphasises the need of complete evaluation in elderly patients with GCA and visual symptoms and the need to start aggressive treatment to prevent visual loss. Case report - Case description 73-year-old caucasian lady presented to the eye emergency department with diplopia. Medical history includes systemic hypertension, hypothyroidism and hyperlipidaemia, no past ocular history. Eye examination was normal except decompensated fourth nerve paresis. Thyroid function was normal. Diplopia resolved spontaneously. Patient re-presented with a floater in the right eye and left-sided atypical headache without jaw claudication. Investigations: normal FBC, CRP 126, ESR 100, PV 1.67. Following rheumatologist review she was commenced on oral prednisolone 60 mg with clinical suspicion of GCA. Temporal artery biopsy confirmed GCA. She had TIA subsequently. MRI revealed small area of acute infarct in left ganglio-capsular region. Clopidogrel was started for secondary prevention. In the ophthalmology clinic she saw a lacy pattern. Her Log MAR VA in right and left eye was 0.64 and 0.76, respectively. Fundoscopy revealed retinal pigment epithelial (RPE) mottling at the maculae, right more than left eye. Optical Coherence Tomography (OCT) macula revealed bilateral RPE elevations and serous pigment epithelial detachment bilaterally, patchy central RPE atrophy with external limiting membrane disruption, more pronounced in the right eye. Fundus fluorescein angiogram and indocyanine green angiography confirmed bilateral choroidal ischaemia (triangular shaped with the base at the equator) at the macula worse in right than left eye. Oral prednisolone was continued with gradual tapering. VA improved to Log MAR 0.5 and Log MAR 0.2 in right and left eye at six weeks. OCT showed signs of RPE re-modelling with resolution of sub retinal fluid (resolution of inflammation). At recent follow up Log MAR VA is 0.26 and 0.06 in right and left eye respectively. She is on oral prednisolone 20 mg once a day tapering 2.5 mg every 2 weeks. OCT shows further re-modelling of the ellipsoid zone in the left eye, but her right eye shows more RPE atrophy and thinning with RPE degeneration. Case report - Discussion We report an unusual case of GCA with atypical symptoms and bilateral choroidal ischaemia. Patients with GCA usually present with systemic symptoms and signs like headache, scalp tenderness, fever, and jaw claudication. Variable presentation can often lead to misdiagnosis and consequent irreversible loss of vision. Visual symptoms as the first and only sign of GCA was first reported in 1952. Posterior ciliary arteries in the eye can be affected leading to optic nerve infarction and subsequent anterior ischaemic optic neuropathy (AION). AION and visual field loss accounts for 80—90% of cases with ocular signs of GCA. Posterior ciliary artery occlusion can rarely cause patches of choroidal infarcts which appear as chorio-retinal degeneration in a couple of weeks. These patches are usually in the mid-peripheral fundus, usually triangular shaped with the base towards equator and apex toward posterior pole. In our case the presentation was very atypical in the sequence of symptoms. Her raised inflammatory markers raised the suspicion of GCA and prompt referral to rheumatology was done. Aggressive treatment with oral steroids was started with stomach and bone protection. Temporal artery biopsy confirmed the diagnosis. The bilateral triangular ischaemic areas found on FFA and ICG confirmed the macular choroidal ischemia. Her OCT also showed bilateral RPE mottling showing degenerative changes due to choroidal infarct from posterior ciliary artery occlusion. We managed to preserve the vision in our case by starting the timely aggressive steroid treatment. In summary, we report an unusual case of GCA with atypical symptoms and bilateral choroidal ischaemia where further visual loss was avoided due to timely intervention. GCA has variety of presentations; a combined team approach of ophthalmologists and rheumatologists can prevent irreversible visual loss in such cases. Case report - Key learning points GCA is a chronic idiopathic inflammation more commonly seen in the large- and medium-sized vessels. Posterior ciliary arteries in the eye can be affected in GCA leading to optic nerve infarction and subsequent anterior ischaemic optic neuropathy (AION). AION and visual field loss accounts for 80—90% of cases with ocular signs of GCA. Posterior ciliary artery occlusion can rarely cause patches of choroidal infarcts which appear as chorio-retinal degeneration in a couple of weeks. These patches are usually in the mid-peripheral fundus, usually triangular shaped with the base towards equator and apex toward posterior pole. Prompt diagnosis and aggressive treatment with corticosteroids can prevent visual loss in one or both eyes. Any patient over 50 years of age presenting with visual symptoms of amaurosis fugax, diplopia, or visual loss with ocular signs of anterior or posterior ischaemic optic neuropathy, central retinal artery occlusion or cilioretinal artery occlusion should create a high suspicion for GCA. This group of patients should have urgent ESR, CRP and PV evaluation. If suspected, high-dose corticosteroids must be started followed by temporal artery biopsy for confirmation. It is imperative to diagnose GCA early and start treatment urgently to prevent visual loss. A multidisciplinary team approach in patients with GCA can prevent sight loss and life too. more...
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- 2021
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7. O31 Central venous access in ventilated COVID-19 patients: a vascular surgery perspective
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D. Lui, P. Liu, S. T. Hussain, S. M. Cheema, M Malina, and T. Husain
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medicine.medical_specialty ,AcademicSubjects/MED00910 ,Referral ,business.industry ,education ,Staffing ,Workload ,Vascular surgery ,Intensive care unit ,law.invention ,Abstracts of The Surgical Research Society (SRS) Annual Meeting 2021, 24th and 25th March 2021 ,medicine.anatomical_structure ,Femoral triangle ,law ,Median follow-up ,Intensive care ,Emergency medicine ,medicine ,Surgery ,AcademicSubjects/MED00010 ,business - Abstract
Introduction The number of patients on intensive care units (ICU) increased manifold during the initial COVID-19 surge and medical staff were relocated to help compensate. The need for central venous catheters (CVCs) increased accordingly and comprised a significant workload under challenging circumstances. Several models were proposed to manage the lines. We assigned a vascular team of vascular surgeons and interventional radiologists for CVCs in ICU. We report on the workload, outcomes and lessons learned. Method 50 consecutive ventilated COVID-19 patients in ICU (median age 63 years, 80% male) who had a CVC inserted by the vascular team from March to May 2020 were assessed. Median follow up was 18 days (range 14– 29 days) after ICU admission. Result 166 CVCs (80 VasCaths) were inserted. Femoral access was preferred. Each patient required a median of 3 lines (IQR 2–4). CVCs were exchanged after median 7 days (IQR 4–9) for thrombosis (35%), infection (24%) or prophylactically (41%). Our learning curve included the establishment of an online referral pathway, CVC teams of two operators, extended disposable CVC kits and ICU based ultrasound scanners. Additional staffing and retraining were avoided. There were no technical complications. Conclusion Ventilated COVID-19 patients require multiple CVCs which is a challenging workload during a pandemic. Vascular surgeons and interventional radiologists with endovascular skills are well positioned to perform central venous cannulation to alleviate the burden on critical care teams. Our lessons learned can help to provide a safe and efficient model amidst the ongoing national outbreaks. Take-home Message With the postponement of many elective vascular procedures during the pandemic crisis, the involvement of vascular surgeons in a dedicated Lines team is an important way that they can contribute given their proficiency with wires and cannulation equipment, as well as familiarity in femoral triangle and jugular anatomy. The retraining of staff and additional on-call rotas can then be avoided. more...
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- 2021
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8. O31. Dietary excess of L-Lys resulted in a linear reduction in feed intake and growth and increased CCK in weaning pigs
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Maximiliano Muller, A. Tilbrook, R. van Barneveld, Marta Navarro, and Eugeni Roura
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- 2022
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9. O31 Feasibility of a Synchronous Virtual Hypertension Management Program for Community-Dwelling Older Adults Through Extension
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Rebecca Rosenstein, Cheryl Bush, Jennifer Dixon Cravens, Mona Habibi, Shauna Henley, Beverly Jackey, Jeanette Jeffrey, Jinhee Kim, Lisa McCoy, Dhruti Patel, Theresa Serio, and Heejung Song
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Nutrition and Dietetics ,Medicine (miscellaneous) - Published
- 2022
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10. O31 Trajectories of anxiety in children young people and adults with rheumatic diseases in the wake of COVID-19: results from the COVID-19 European patient registry
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Richard P Beesley, Suzanne M M Verstappen, Wendy Costello, Yosef Uziel, Stephanie J W Shoop-Worrall, Carine Wouters, Saskya P Angevare, and Nico M Wulffraat
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medicine.medical_specialty ,Patient registry ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Registers ,Oligoarticular JIA ,Disease ,medicine.disease ,Comorbidity ,Oral Abstract Presentations ,Rheumatology ,Internal medicine ,Cohort ,Medicine ,Anxiety ,Pharmacology (medical) ,medicine.symptom ,business ,Prospective cohort study ,AcademicSubjects/MED00360 - Abstract
Background/Aims Younger and older people with rheumatic diseases may experience increased anxiety during the COVID-19 pandemic, due to the uncertainty regarding their likelihood of contracting the virus, its complications alongside their existing condition and whether their immunosuppressive treatments pose additional risks. This study explored trajectories of anxiety in parents of children and young people (CYP) with rheumatic diseases and adults with rheumatic diseases in the six months following March 2020 during the COVID-19 pandemic. Methods CYP and adults recruited to the international COVID-19 European Patient Registry, a parent-led, online, self-referred prospective cohort recruiting participants globally, were selected if enrolled within 20th March to 17th April 2020. Anxiety scores (0-10, 10=Highest anxiety) were collected weekly for up to 28 weeks and denoted parent anxiety in the CYP cohort and self-reported anxiety in the adult cohort. Group-based trajectory models explored anxiety clusters using censored-normal models in the CYP and adult populations, separately. Linear, quadratic and cubic polynomials were tested within 1 to 10 clusters and optimal models selected based on a combination of model fit (BIC), parsimony and clinical plausibility. Demographic (country, age, gender) and clinical (diagnosis, disease control, respiratory comorbidity, immunosuppressive therapy) information and COVID-19 mitigation behaviours (isolation, distancing, none) were collected at initial enrolment and compared between clusters using Chi-squared, Fisher’s exact and Kruskal-Wallis tests. Results Among 498 CYP and 2640 adults, most were female (65%, 89%) and from the UK (50%, 84%), respectively. The most common diagnoses were polyarticular JIA (37%) and oligoarticular JIA (29%) among CYP and RA among the adults (63%). Respiratory comorbidities were uncommon in the CYP (10%) and adult (17%) cohorts, and most were taking any immunosuppressive therapies (85%, 87%), respectively. As of March 2020, 88% and 79% were self-isolating, respectively. In both the parents of CYP and adult cohorts, four trajectory clusters were identified with similar patterns: Persistent extremely high anxiety (32%, 17%), persistent high anxiety (43%, 41%), high anxiety that marginally improved (25%, 32%) and moderate anxiety that improved (11%, 10%). Among CYP, few characteristics distinguished the clusters. However, in the adult cohort, clusters with greater and more persistent anxiety were associated with higher levels of respiratory comorbidities, higher use of immunosuppressive therapies, higher initial levels of self-isolation and slightly older age than those with lower or improving anxiety over time. Conclusion This study reports four trajectories of anxiety during the COVID-19 pandemic that are consistent across parents of CYP with rheumatic diseases and among adults with these conditions. Despite relatively lower risks for CYP, parental anxiety regarding COVID-19 was high and not associated with characteristics of their child or of their child's disease. Among adults with rheumatic diseases, greater anxiety was associated with risk factors potentially associated with COVID-19 morbidity and mortality. Disclosure S.J.W. Shoop-Worrall: None. S.M.M. Verstappen: None. W. Costello: None. S.P. Angevare: None. Y. Uziel: None. C. Wouters: None. N. Wulffraat: Honoraria; Sobi. Grants/research support; Abbvie. R. Beesley: None. more...
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- 2021
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11. O31: CORRELATION BETWEEN THYROID FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) SCORES AND CANCER INCIDENCE ON FINAL HISTOPATHOLOGY – A MULTI-CENTRE RETROSPECTIVE ANALYSIS
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F Crowley, J McCarthy, P Sheehan, A Diaz, Henry Paul Redmond, Mudassar Majeed, O Iwegbulem, David Cagney, and Zeeshan Razzaq
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Bethesda system ,Thyroid ,Cancer ,medicine.disease ,medicine.anatomical_structure ,Cancer incidence ,Cytology ,medicine ,Surgery ,Histopathology ,Radiology ,Multi centre ,business ,Thyroid cancer - Abstract
Introduction Fine Needle Aspiration Cytology (FNAC) is the best diagnostic tool for evaluating thyroid nodules pre-operatively. The Bethesda System for Reporting Thyroid Cyto-pathology (TBSRTC) in America and THY classification in Europe are standardized reporting systems for thyroid FNAC specimens using six categories. As compared to the first edition in 2009, a second edition of TBSRTC published in 2017 has revised risk of malignancy (ROM) for these categories, with focus on atypia of unknown significance (Thy3A) upgraded to 10-30% from previously 5-15%, and suspicion for follicular neoplasm (Thy3F) 25-40% from previous 15-30%. Method A three-year audit of thyroid surgeries performed in two high volume thyroid institutions from January 2016 to September 2019, was performed retrospectively. The FNAs were performed by thyroid specialist radiologists with a cytopathology technician in attendance for rapid on-site evaluation and reported as per TBSRTC and Thy classification, by a Consultant Cyto-pathologist from a single institution. Result A total of 702 patients were examined. There were 552 patients who had corresponding FNAC prior to surgery (mean age 53.6 years, females 79%). The rates of malignancy were, Thy1: 9.3%, Thy2: 4.6%, Thy3A: 10.8%, Thy3F: 28.7%, Thy4: 82.3% and Thy5: 100%. The main types of thyroid malignancy were Papillary (73.6%), Follicular (14.1%), Medullary (4%), Anaplastic (4.7%) and others (3.6%). Conclusion Pre-operative diagnosis of thyroid nodules using TBSRTC was comparable and the criteria helped avoid misinterpretation of results. Our results were comparable with the risk of malignancy in 2009 edition of TBSRTC, as compared to the 2017 revision. Take-home message Pre-operative diagnosis of thyroid nodules using The Bethesda System for Reporting Thyroid Cyto-pathology (TBSRTC) was comparable and the criteria helped avoid misinterpretation of results. Our results were comparable with the risk of malignancy in 2009 edition of TBSRTC, as compared to the 2017 revision. more...
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- 2021
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12. O31 Pixel-based deep learning models, a step closer to real-time computer-assisted detection of Barrett’s Neoplasia
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Pradeep Bhandari, Mohamed Abdelrahim, Masahiro Saiko, Ejaz Hossain, Sophie Arndtz, and Yukiko Masaike
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Computer science ,business.industry ,Deep learning ,Pixel based ,Computer vision ,Artificial intelligence ,business - Published
- 2021
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13. O31 Determining Low-Income Fathers’ Preferred mHealth Nutrition-Related Topics, Features, and Delivery Methods
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Kari Adamsons, Amy R. Mobley, Elder Varela, Kim M. Gans, and Jamie Zeldman
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Nutrition and Dietetics ,Descriptive statistics ,Nutrition Education ,Theory of planned behavior ,Medicine (miscellaneous) ,Social media ,Meal preparation ,Psychology ,Mental health ,mHealth ,Developmental psychology ,Qualitative research - Abstract
Background There is limited evidence about fathers’ preferences related to using mHealth tools to receive nutrition and obesity prevention information for their preschool aged children. Objective The purpose of this qualitative study was to determine fathers’ preferred mHealth nutrition-related topics, features, and delivery methods. Study Design, Setting, Participants Low-income fathers (n = 29) of preschool aged children from 2 US states were individually interviewed by a trained research assistant using a semi-structured interview script. Measurable Outcome/Analysis Interview questions were based on the Theory of Planned Behavior to determine fathers’ subjective norms, preferences, and attitudes towards mHealth tools, content and video preferences, and behavioral intentions related to using mHealth tools. The classic analysis approach was used to determine major themes from transcribed interviews. Descriptive statistics of participants were derived from a demographics questionnaire. Results Fathers were, on average, 36 years old, and the majority were non-White (69%) and non-Hispanic (79%), with almost half having a high school education or less (48%). Overall themes indicated that fathers preferred mHealth tools such as an app, social media, videos, text messages, and email. There were mixed opinions on the use of memes and GIFs. Requested topics included healthy eating, child feeding, meal preparation, food safety, physical activity, and mental health related information. Features should include practical tips, meal plans, recipes, a calendar with healthy lifestyle reminders, options to connect with other fathers, and personalization for their child. Content should be short, funny, appealing, engaging, informational, beneficial, and include visuals, yet be credible, relatable, and straightforward. Frequency of information should be posted or shared every day or at least once or twice a week. Conclusion The use of an app or social media to communicate healthy eating and child feeding information to low-income fathers of preschool age children may be a viable nutrition education strategy. Funding NIFA. more...
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- 2021
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14. O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome
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Gareth Jones, Felice Rivellese, Simon Jones, Michele Bombardieri, Elena Pontarini, Ian R. Humphreys, Edoardo Prediletto, David Hill, Alicia Derrac Soria, Anwar R. Tappuni, Rachel Coleby, Davide Lucchesi, Costantino Pitzalis, and Nurhan Sutcliffe more...
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Interferon type II ,business.industry ,medicine.medical_treatment ,Germinal center ,medicine.disease ,medicine.disease_cause ,Sialadenitis ,Autoimmunity ,Cytokine ,Immune system ,Rheumatology ,Immunology ,medicine ,Pharmacology (medical) ,Interleukin 17 ,Interleukin 27 ,business ,medicine.drug - Abstract
Background A third of Sjögren’s syndrome (SS) patients develop ectopic lymphoid structures (ELS) in their salivary glands (SG). ELS play an active role in autoimmunity and contribute to the development of MALT lymphoma. Interleukin 27 (IL-27) exerts key immunomodulatory actions on numerous immune cells but its role in the formation and regulation of ELS in the SG of SS is unknown. Here we used a murine model of SG ELS to elucidate the role of IL-27 and its interaction with IL-17 in the development, regulation and function of ELS. We extended our observations on a cohort of SS patients to identify IL-27 cellular source, target cells and functional properties in modulating CD4 T cells function. Methods A single dose of reporter-encoding adenovirus was delivered directly to the SG of wild-type (WT) and IL-27RA-deficient (KO) mice to trigger ELS formation. For IL-17 blockade, anti-mouse IL-17A antibody was used. ELS development and peripheral immune responses were tracked by immuno-histopathology, FACS, and qPCR. Minor SG biopsies were collected from SS and non-specific sialadenitis (sicca) patients. Peripheral blood mononuclear cells (PBMC) isolated from SS and rheumatoid arthritis (RA) patients and age/sex-matched healthy donors (HD). For in vitro experiments PBMCs were incubated with IL-27 and analysed by FACS and cytokines levels were measured in culture supernatants. Tissue IL-27 was assessed by multicolour immunofluorescence. Results In WT mice, SG ELS formation was preceded by upregulation of IL-27p28 and infiltration of IL-27 producing cells. KO mice displayed larger, more abundant ELS in the SG. Higher expression levels of ELS-related genes (Cxcl13, Ccl19, Ltb, Aid) compared to WT mice were measured. KO mice showed an uncontrolled SG Th17 response and systemic IL-17A blockade caused a reduction in ELS size and in the expression of ELS-related genes. In SS patients SG and serum, we observed higher expression levels of IL-27 transcripts and protein, compared to sicca. SG IL-27 was selectively increased in ELS+ patients. IL-27 staining was detected in the T cell-rich areas of SG ELS often co-localizing with DC-LAMP+ dendritic cells. While IL-27 was able to significantly downregulate IL-17 production in HD and RA, CD4 T cells from patients with SS failed to downregulate IL-17 but showed an aberrant IFNγ release upon IL-27 incubation. Conclusion The IL-27-mediated restriction of Th17 expansion plays a critical role in the regulation of germinal centre response. Both in murine inducible ELS and in patients with SS, dendritic cells appear as the main cellular source of IL-27. IL-27 consistently failed to downregulate IL-17 release in CD4 T cells from SS patients, albeit its expression was increased in the ELS+ subset of SS, suggesting that a profound dysregulation of the IL-27/IL-17 axis play an important role in ELS formation in this condition. Disclosures D. Lucchesi None. R. Coleby None. E. Pontarini None. E. Prediletto None. F. Rivellese None. D. Hill None. A. Derrac Soria None. S. Jones None. I. Humphreys None. N. Sutcliffe None. A. Tappuni None. C. Pitzalis None. G. Jones None. M. Bombardieri None. more...
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- 2020
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15. O31 Integrative analysis reveals a molecular stratification of systemic autoimmune diseases
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Carlo Chizzolini, Yolanda Jiménez Gómez, Pier Luigi Meroni, M.C. Castro-Villegas, Ralf Lesche, Fernanda Genre, Javier Martín, Raquel Faria, Márta Bocskai, Tommaso Schioppo, Emanuele de Rinaldis, Divi Cornec, Torsten Witte, Pierre-Emmanuel Jouve, Sikander Hayat, Johan Frostegård, Guillermo Barturen, Christophe Jamin, Laleh Khodadadi, Alfonso Corrales Martínez, Quentin Simon, Mariana Brandão, Chris Chamberlain, Alain Saraux, Javier Rodríguez-Ubreva, Francesc Català-Moll, Michaela Lehner, Ricard Cervera, Tania F. Rowley, Tianlu Li, Attila Balog, Enrique de Ramón, Maria Angeles Aguirre-Zamorano, Elena Carnero-Montoro, Rafaela Ortega-Castro, László Kovács, Velia Gerl, Carolina Artusi, Nancy Azevedo, Martin Kerick, Antonio López-Berrio, Esmeralda Neves, Anne-Lise Maudoux, Bénédicte Rouvière, Bernard Lauwerys, Maria Gerosa, Yiannis Ioannou, Fátima Farinha, Ian White, Tania Anjos, Sepideh Babaei, N.T. Baerlecken, Katja Kniesch, Jonathan Cremer, Joerg Mueller, Julie Ducreux, Lucas Le Lann, Norberto Ortego, Jerome Wojcik, Marialbert Acosta-Herrera, Maria Hernandez-Fuentes, Héctor Navarro-Linares, Maria Orietta Borghi, Inmaculada Jiménez Moleón, António Marinho, Rocío Aguilar-Quesada, Enrique Raya, Falk Hiepe, Raquel López Mejías, Mcdonald Fiona Mcdougall, Robert J. Benschop, Georg Stummvoll, Isabel Díaz Quintero, Esteban Ballestar, Aleksandra Maria Dufour, Jordi Martorell-Marugán, Elena Trombetta, Manuel Rodriguez Maresca, Miguel A. González-Gay, Valérie Devauchelle-Pensec, Maria Juarez, Carlos Vasconcelos, Doreen Belz, Yves Renaudineau, Donatienne Wynar, Jacqueline Marovac, Aurélie De Groof, Sandrine Jousse-Joulin, Alejandro Escudero-Contreras, Laurence Laigle, Ignasi Rodríguez-Pintó, Zuzanna Makowska, Isabel Almeida, Lorenzo Beretta, Damiana Álvarez-Errico, Nieves Varela, Montserrat Alvarez, Concepción Marañón, Ricardo Blanco Alonso, Daniel Toro-Domínguez, Ana Campar, Manuel Martínez-Bueno, Barbara Vigone, Francisco Javier Garrancho, Rik Lories, Gabriella Kádár, Michael Zauner, Silvia Thiel, Pedro Carmona-Sáez, María Concepción Fernández Roldán, Magdolna Deák, Marta E. Alarcón-Riquelme, Rosario Lopez-Pedrera, Qingyu Cheng, Sonja Dulic, Sara Remuzgo, Ana Lisa Taylor Tavares, Gerard Espinosa, Gaia Montanelli, Nuria Barbarroja, Sambasiva P. Rao, Eduardo Collantes-Estevez, Anne Buttgereit, Begoña Ubilla Garcia, Ernst R. Dow, Jorge Kageyama, Antonio Garcia-Gomez, Jacques-Olivier Pers, Nicolas Hunzelmann, and Ellen De Langhe more...
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Oncology ,medicine.medical_specialty ,Disease clusters ,business.industry ,Disease progression ,INCEPTION COHORT ,Internal medicine ,T cell immunity ,medicine ,Effective treatment ,Christian ministry ,Medical diagnosis ,business ,Unsupervised clustering - Abstract
Background Clinical heterogeneity, a hallmark of systemic autoimmune diseases (SADs) impedes early diagnosis and effective treatment, issues that may be addressed if patients could be grouped into a molecular defined stratification. Methods With the aim of reclassifying SADs independently of the clinical diagnoses, unsupervised clustering of integrated whole blood transcriptome and methylome cross-sectional data of 918 patients with 7 SADs and 263 healthy controls was undertaken. An inception cohort prospectively followed for 6 and 14 months was studied to validate the results in early cases and analyze if cluster assignment was modified with time. Results Four clusters were identified Three aberrant clusters were ‘acute phase inflammatory’, ‘T cell immunity’, and ‘interferon’, each including all diagnoses, were defined by genetic, clinical, serological and cellular features. A fourth cluster showed no specific molecular pattern, to which 74% of healthy controls clustered with patients. The inception cohort showed that most patients were either assigned always to the same cluster or moved from the healthy-like cluster to a single aberrant cluster resembling the relapsing-remitting dynamic of these diseases, showing that single aberrant molecular signatures characterize each individual patient. Conclusions Patients with SADs share molecular signatures and can be therefore stratified into three disease clusters differentiating each patient into a specific molecular disease pathway. Such assignment is stable with time. These results have important implications for understanding disease progression and therapy design marking a paradigm shift in our view of SADs. Acknowledgment This work has been supported through a grant from the Innovative Medicines Initiative Joint Undertaking No. 115565 and in-kind and in-cash contributions from the EFPIA partners. G.B. is supported by the Instituto de Salud Carlos III (ISCIII, Spanish Health Ministry), through the Sara Borrell subprogram (CD18/00153). The authors would like to particularly express their gratitude to the patients, nurses and many others who helped directly or indirectly in the consecution of this study. more...
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- 2020
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16. O31 Criticalcare simulation in undergraduate obstetrics & gynaecology at trinity college dublin: how this early application can make a difference
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Gareth Morrison, Claire Thompson, Deidre J. Murphy, Ronan Daly, and Richard P. Deane
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Medical education ,Academic year ,Obstetrics and gynaecology ,business.industry ,Critically ill ,Statistical significance ,education ,Medical training ,Final examination ,business ,Psychology ,Session (web analytics) ,Obstetrics gynaecology - Abstract
Introduction Undergraduate critical care training is often sub-optimal. Poor recognition combined with lack of knowledge, failure to appreciate clinical urgency or seek advice and poor communication have been identified as contributory factors. In a recent Year 4 student evaluation conducted by Trinity College Dublin (TCD), only 23% stated that current undergraduate training would prepare them adequately to care for acutely ill patients. To address this, a 2-hour simulation training session on critical care in Obstetrics and Gynaecology was designed. Methods Observational study comparing student performance managing a critical care scenario before and following a new critical care simulation training session. This applied a systematic ABCDE approach with an Assess, Intervene and Review (AIR) strategy. Students then applied this in simulated cases. Ethics approval obtained through TCD Ethics Committee. Participation was voluntary and assurance that this study would not impact final examination results. Students within the last rotation of the academic year were invited. They completed an anonymised Pre- and Post-simulation session questionnaire on their confidence in assessing/starting basic management of Airway/Breathing/Circulation/Disability/Exposure. Rated as 1 (no confidence) till 5 (very confident). Two 8-minute OSCE structured assessments were designed (First held at the beginning of the rotation/pre-simulation and then at the end of rotation/post-simulation). Clinical scenarios were marked against a standardised proforma by trained TCD staff. Statistical analysis was performed via 2 tailed T-test. Results 27 students took part. On pre-simulation questionnaires, 37% felt unconfident that current training prepared them for caring for critically ill patients. However, following the simulation training, student confidence levels rose in all areas and achieved statistical significance. ABCDE assessment: t–value 5.23273 p–value Airway: t–value is 3.64701, p–value 0.000316. Breathing: t–value is 5.20154, p–value Circulation: t–value 6.65139, p–value Disability: t–value 9.17396, p–value is Exposure: t–value is 8.28241, p–value is 100% wanted more simulation in the undergraduate curriculum. Objectively students showed statically significant improvement in their OSCE scores and their global assessments. On comparison of the two assessments: t-value 6.37027, p-value Discussion/Conclusions Despite the small study number, a clear statistical improvement in performance was seen following the new simulation session. Feedback from the entire year group has been positive. Early application of simulation is now essential in medical training. This includes undergraduate level, in order to prepare students adequately to provide effective and safe patient care. We therefore fully recommend this approach to expand in undergraduate training. more...
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- 2019
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17. O31 Cardiac Rehabilitation: A challenge for Health literacy
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S Medeiros, C André, C Alexandre, S Santo, and J Santos
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Rehabilitation ,Nursing ,business.industry ,medicine.medical_treatment ,Public Health, Environmental and Occupational Health ,Medicine ,Health literacy ,business - Published
- 2019
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18. O31 The usability of electronic patient-reported outcomes prior to rheumatology clinic attendance: could this be the future in managing demand on rheumatology services?
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Toby Garrood, Melanie J Martin, and Mark Bartlett
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medicine.medical_specialty ,Rheumatology ,Rheumatology clinic ,Patient Self-Report ,business.industry ,Family medicine ,Internal medicine ,medicine ,Attendance ,Pharmacology (medical) ,Usability ,business - Published
- 2019
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19. O31 Therapeutic itineraries and childhood cancer in argentina: peripheral perspectives
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Eugenia Brage
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Medical treatment ,business.industry ,media_common.quotation_subject ,Childhood cancer ,Disease ,Health services ,Presentation ,Nursing ,Ethnography ,Public hospital ,Medicine ,business ,Medical anthropology ,media_common - Abstract
Content In Argentina the attention of some childhood diseases, such as cancer, is centralized in Buenos Aires. About half of the children who fall ill with cancer must migrate to another city in search of diagnosis or medical treatment for this disease. This gives rise to different forms of territorial mobility for access to health services, a topic that has not received much attention in medical anthropology. The aim of this presentation is to share the results of a doctoral research work about the therapeutic itineraries and care practices carried out by parents of children affected by cancer. The ethnographic fieldwork was carried out during May 2013 to December 2015 at a public Hospital located in Buenos Aires, as well as a non-governmental organization created to support low-income families who are suffering from this disease and, finally, a hotel where some families stay when they arrive to Buenos Aires during the period of the medical treatment and controls. The methodology consisted on observations and semi-structured interviews to child’s parents and primary carers. I will try to bring to discussion some theoretical and methodological implications about the notion of therapeutic itinerary, a category that has gained strength due to its enormous explanatory and analytical potential. Based on analyzing the reality of our health services, the work aims to expose the potential of ‘peripheral perspectives’1 to cope with a highly changing and uneven world. Reference Oliveira LRCd. O oficio do antropologo, ou como desvendar evidencias simbolicas.Anuario Antropologico Brasilia: Departamento de Antropologia, UnB, 2008 2007. more...
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- 2019
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20. O31 Evaluating Success of Paraprofessional Educators in a Pilot Adolescent Classroom Intervention: Rev It Up!
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Debra Palmer-Keenan, Het Desai-Shah, and Graham E. Bastian
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Expanded Food and Nutrition Education Program ,Medical education ,Class (computer programming) ,Nutrition and Dietetics ,Intervention (counseling) ,Nutrition Education ,Food choice ,Theory of planned behavior ,Medicine (miscellaneous) ,Target audience ,Psychology ,Curriculum - Abstract
Objective To evaluate Rev It Up!, a pilot nutrition education curriculum for teens, when it is taught by either paraprofessional or professional educators. Use of Theory or Research Research shows teens consume low levels of fruits, vegetables, and whole grain foods; and excessive levels of sugar-sweetened beverages and fast foods. Further, they do not meet physical activity (PA) recommendations. Rev It Up!, which was informed by the Theory of Planned Behavior, addresses these issues with teens, an audience at the inception of controlling their own food choices. Target Audience Urban teens (N=118) in high school health classes participating in the NJ Expanded Food and Nutrition Education Program (EFNEP). Eighty-five were taught by professional staff (2018-2019 school year); the other 33 were taught by paraprofessionals (2019-2020 school year). Program Description Rev It Up! is a 10-lesson curriculum that employs gamification to provide nutrition and PA education. Evaluation Methods The curriculum was assessed using the EFNEP 9-12th Grade Nutrition Education Survey, pre- and post-education. Results Wilcoxon Signed Rank tests revealed that, pre- to post-intervention, students taught by professionals reported improvements in fruit consumption (P Conclusion Rev It Up! shows promise in being a curriculum that paraprofessionals can utilize to improve teen's nutrition behaviors. One limitation is that class periods were often too short to teach PA, which may account for the lack of reported improvements in PA behaviors. Future curriculum revisions should ensure that both nutrition and PA activities can be adequately addressed during allotted class periods. Funding Expanded Food and Nutrition Education Program. more...
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- 2020
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21. O31 Value for money: a biologic pharmacist clinic
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Philip Kirkpatrick, Amit Sahni, and Mark Lloyd
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medicine.medical_specialty ,Rheumatology ,business.industry ,Value for money ,Family medicine ,medicine ,Pharmacist ,Pharmacology (medical) ,business - Published
- 2018
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22. O31 Preparing for specialty practice in paediatrics: supporting our trainees
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A Ruffle, N Schindler, and FE Brooke
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Pediatrics ,medicine.medical_specialty ,education ,Specialty ,medicine.disease ,Likert scale ,Educational support ,Preparedness ,Workforce ,medicine ,Attrition ,Technical skills ,Psychology ,Umbilical catheter - Abstract
Background Paediatrics is in recruitment and retention crisis with a fall in ST1 applications of 12.2% in 2016. The foundation doctors applying may have limited Paediatric exposure as only 2.6% of FY1% and 6% of FY2 jobs are based in Paediatrics. 1 10% of Paediatric trainees leave specialty by ST3% and 40% have considered leaving the specialty. 2 A key factor in attracting and retaining doctors is to offer a balance between clinical and educational exposure. Paediatrics lends itself well to simulated education as the scenarios encountered are often low yield but high risk and opportunities for skills practice are limited. Aim To support trainees’ ‘readiness’ to begin Paediatric clinical practice via a curriculum-mapped simulation based course to address technical skills. By increasing preparedness for Paediatric training it is hoped that this may improve retention of trainees within the deanery by offering a supportive environment alongside other School of Paediatrics initiatives. Methods The ‘ST1 Study Day: Paediatrics’ course included: airway, umbilical catheter and lumbar puncture skill stations with simulation scenarios of common emergencies. Advertisement was through the local HEEoE team to ST1 trainees and the course was funded by HEEoE School of Paediatrics. Feedback was completed at the end of the course. Results A Likert scale was used to score candidates’ (n=12) self-perceived ‘readiness’ at the start of ST1 Paediatrics, with 1 the lowest and 10 the highest level of ‘readiness’; mean readiness prior to starting ST1 was 4.8. All candidates evaluated the course as helpful with an average score of 9. 100% of candidates would recommend the course to other trainees. Course feedback was positive and praised the ‘supportive’ and ‘informal’ environment with a ‘good selection’ of simulated scenarios that were ‘applicable to real life’. Requests for further courses included more skills and scenarios with refresher courses during the year. Conclusions This pilot course demonstrates that new ST1 Paediatricians do not self-evaluate as ‘ready’ to start their training program and they perceive a need for a course providing simulated skills and scenarios practice. Further areas for analysis include assessment of ST1 trainees at the start of their training program and impact on retention. The format of this course could be recreated by other sub-specialties within HEEoE where trainees have limited foundation years’ exposure to the sub-specialty. We hope simulation courses such as this within our deanery will improve educational support and encourage retention of these skilled doctors. References . Simon Broughton, Consultant Paediatrician. A workforce crisis in paediatrics – Failure to thrive? BMJ Letter 4th May, 2016. . Helen Jaques. News reporter BMJ careers: Royal college reports attrition and dissatisfaction among paediatrics trainees. BMJ Careers 12th January, 2013. more...
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- 2017
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23. O31 Effectiveness of balance training and strength training protocols to improve functional clinical and patient-reported outcomes
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Jackie J. Kingma, Carrie L. Docherty, Emily A. Hall, and AK Chomistek
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Univariate analysis ,medicine.medical_specialty ,Strength training ,business.industry ,education ,Repeated measures design ,law.invention ,medicine.anatomical_structure ,Physical medicine and rehabilitation ,Randomized controlled trial ,Multivariate analysis of variance ,law ,medicine ,Physical therapy ,Analysis of variance ,Ankle ,business ,Balance (ability) - Abstract
Study Design Randomised Controlled Trial. Objectives Determine the effect of balance and strength training protocols on improving deficits in patients with chronic ankle instability (CAI). Background Functional deficits arise following a lateral ankle sprain and individuals with CAI can experience long-term disability. Healthcare practitioners should use functional rehabilitation to improve these deficits. Methods and Measures Thirty-nine participants with CAI volunteered for this study. Identification of Functional Ankle Instability Questionnaire(IdFAI) determined CAI status. Participants were randomly assigned to: Balance Training Protocol(BTP), Strength Training Protocol(STP), and Control Group(CON). The BTP group completed hop-to-stabilisation balance training, the STP group completed resistance band and PNF strength protocol, and the CON group completed a bike workout. Participants completed training 3x/week for six weeks. Clinical outcome (Balance Error Scoring System(BESS), Star Excursion Balance Test(SEBT), and Side Hop Test(SHT)) and patient-reported outcome measures (Foot and Ankle Ability Measure Sport(FAAM-Sport) and Disablement of Physical Activity(DPA)) were evaluated prior to and following the 6 week training. Two multivariate repeated measures ANOVAs were conducted with follow-up univariate analyses. Results The MANOVA yielded a significant time by group interaction for the clinical measures(p 0.05) in any clinical outcome measure. No significant time-by-group interactions were identified when evaluating the MANOVA of the patient-reported outcomes(p=0.52). However, there was a significant main effect for time (p=0.001). Follow-up analyses revealed significant differences between the pre-test to posttest for the DPAS(p=0.02) and FAAM-Sport(p=0.001). Conclusion Both training protocols significantly improved balance and functional performance, but all groups improved patient-reported outcomes. more...
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- 2017
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24. O31 Levetiracetam monitoring in breast-milk: high inter-individual variability
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N Agajani, L Ben-Nun, Natalie Dinavitser, Rimona Keidar, R Sheinberg, Ayelet Livne, Elkana Kohn, Maya Berlin, D Stepenski, Nurit Brandriss, Matitiahu Berkovitch, H Flor-Hirsch, A Bar-Chaim, and S Gamsu more...
- Subjects
Pregnancy ,medicine.medical_specialty ,business.industry ,Obstetrics ,High variability ,Breastfeeding ,Breast milk ,medicine.disease ,Excretion ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,medicine.anatomical_structure ,030225 pediatrics ,Lactation ,Pediatrics, Perinatology and Child Health ,medicine ,Levetiracetam ,business ,medicine.drug - Abstract
BackgroundAnti-epileptic drug therapy is a great challenge for the practitioners during pregnancy and lactation. Levetiracetam (LEV) is commonly prescribed to pregnant women, however, there are only few publications on its use during lactation with small number of participants.ObjectiveTo monitor LEV levels in breast-milk of epileptic mothers treated with LEV.MethodsBreastfeeding women treated with LEV during pregnancy and after delivery were recruited. Milk sample was collected before administration of the drug and other samples were collected at time points of 1,3,6,9, and 12 hours after drug administration. Breastmilk and blood LEV levels were measured using HPLC.ResultsFourteen breastfeeding women participated in the study: 9 infants were fully breastfed whereas 5 were partially breastfed. Maternal average daily dose of LEV was 2517 mg. Average infant´s age was 8 weeks (3–22w). Average infant´s weight 4368 gr (3300–7000 gr). Milk/Plasma LEV concentration ratio was 0.88 (0.23–1.1). Relative Infant Dose (RID) was 40% in partial breast feeding, and 61% in full breastfeeding. Estimated average daily dose that all infants received through milk was 158 mg/d (83–250 mg). The normalized dose for the average infant weight per day was 36 mg, which is 15% less than the maximal daily dose of LEV in infants (max. daily dose in infants 1–6 months in 42 mg/d). No adverse reactions were observed in the breastfeed infants.ConclusionsAlthough the RID of LEV were found to be high, no adverse reactions were observed in the infants; Nevertheless, further studies are needed to elucidate the high variability of LEV excretion into breastmilk.Disclosure(s)Nothing to disclose more...
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- 2019
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25. O31. The Impact of Network Topology on Individual Differences in Cognition and Symptomatology
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Dost Öngür, Synthia Guimond, George Ling, Kathryn E. Lewandowski, Neeraj Tandon, Ivy Lee, Olivia Lutz, Mark A. Halko, Matcheri S. Keshavan, Shaun M. Eack, Roscoe O. Brady, and Uzma Nawaz
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Cognition ,Psychology ,Network topology ,Biological Psychiatry ,Cognitive psychology - Published
- 2019
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26. Structure of the O-polysaccharide from the lipopolysaccharide of Providencia alcalifaciens O31 containing an ether of d-mannose with (2R,4R)-2,4-dihydroxypentanoic acid
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Magdalena Bialczak-Kokot, Alexander S. Shashkov, Yuriy A. Knirel, Antoni Rozalski, Olga G. Ovchinnikova, and Nina A. Kocharova
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Lipopolysaccharides ,Glycan ,Magnetic Resonance Spectroscopy ,Stereochemistry ,Molecular Sequence Data ,Mannose ,Ether ,Providencia ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Tetrasaccharide ,Pentanoic Acids ,Ether cleavage ,Molecular Structure ,biology ,Chemistry ,Polysaccharides, Bacterial ,Organic Chemistry ,Absolute configuration ,General Medicine ,Nuclear magnetic resonance spectroscopy ,Carbon-13 NMR ,Carbohydrate Sequence ,biology.protein - Abstract
Recently, ether-linked diastereomeric 2,4-dihydroxypentanoic acids have been reported as new components of bacterial glycans [Shashkov, A. S. et al.Nat. Prod. Commun.2008, 3, 1625-1630]. In this work, an ether of (2R,4R)-2,4-dihydroxypentanoic acid (Dhpa) with d-mannose was identified in the O-polysaccharide of Providencia alcalifaciens O31, and the polysaccharide structure was elucidated. Studies by NMR spectroscopy confirmed the ether linkage between O-2 of Dhpa and O-4 of Man, and the absolute configuration of Man was determined after ether cleavage with boron trichloride. In the polysaccharide, Dhpa was found to exist partially in the form of 1,4-lactone. Using sugar and methylation analyses along with (1)H and (13)C NMR spectroscopy, including 2D (1)H,(1)H COSY, TOCSY, ROESY, H-detected (1)H,(13)C HSQC, and gHMBC experiments, the following structure of the tetrasaccharide repeating unit of the polysaccharide was established: [carbohydrate structure: see text] more...
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- 2009
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27. O31 Influence of Joint Pain on the Incidence and Progression of Disability in the Very Old: The Newcastle 85+ Study
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Blossom C. M. Stephan, Rachel Duncan, Andrew Kingston, Carol Jagger, Fraser Birrell, and Thomas B. L. Kirkwood
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Gerontology ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Joint pain ,medicine ,Physical therapy ,medicine.symptom ,business - Published
- 2016
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28. O31 Can colonic metabolites be responsible for the hypotensive effect of orally given quercetin?
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Iveta Najmanová, Thomas Migkos, Jana Pourová, Premysl Mladenka, and Marie Vopršalová
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Pharmacology ,chemistry.chemical_classification ,Aorta ,Chemistry ,Metabolite ,Flavonoid ,Vasodilation ,Biochemistry ,chemistry.chemical_compound ,Blood pressure ,medicine.anatomical_structure ,In vivo ,medicine.artery ,medicine ,heterocyclic compounds ,Quercetin ,Artery - Abstract
Epidemiologic data suggest protective effects of higher flavonoid intake on cardiovascular diseases. Some human and animal studies reported a decrease in arterial blood pressure after quercetin administration. The mechanism of this effect is not yet well-understood since the closes metabolites of quercetin are either inactive or present in very low plasma concentrations. In this study, a series of colonic quercetin metabolites was analysed. First, the effects on isolated rat aorta were evaluated. Subsequently, the efficient metabolites were also tested in vivo on normotensive and hypertensive rats and in vitro on mesenteric artery. Screening in aorta clearly showed 3-(3-hydroxyphenyl) propionic acid to be the most efficient. These results were confirmed in vivo , where this metabolite decreased arterial blood pressure in hypertensive rats. Further mechanistic experiments confirmed that this effect was based on vasodilation of vessels, no negative effects on the heart were observed. Interestingly, additional experiments showed that two other metabolites with lower effects in the aorta, were also able to reduce blood pressure in rats. Interestingly, these metabolites seemed to have better effects on resistance vessels than on aorta in comparison to 3-(3-hydroxyphenyl) propionic acid. Some colonic metabolites of quercetin are able to decrease the arterial blood pressure in rats. Future experiments are necessary to verify whether these effects can be long-lasting and clinically relevant. more...
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- 2017
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29. Synthesis, crystal structure and property of a novel Nickel-containing tungstophosphate [Na3(H2O)8{Ni3(H2O)(B-α-PW9O34)(B-β-PW8 O31)}2]21−
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Zhifeng Zhao, Baibin Zhou, Lili Chu, Zhanhua Su, Chunxiao Wang, and Kai Yu
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Aqueous solution ,Chemistry ,chemistry.chemical_element ,General Chemistry ,Buffer solution ,Crystal structure ,Condensed Matter Physics ,Electrochemistry ,Redox ,Ion ,chemistry.chemical_compound ,Nickel ,Crystallography ,General Materials Science ,Cyclic voltammetry - Abstract
A novel 6-Nickel-substituted tungstophosphate Na 21 [Na 3 (H 2 O) 8 {Ni 3 (H 2 O)(B-α-PW 9 O 34 )(B-β-PW 8 O 31 )} 2 ]·36H 2 O(1) has been successfully synthesized in aqueous solution and structurally characterized by single-crystal X-ray diffraction, elemental analysis, TG and IR. Polyanion [Na 3 (H 2 O) 8 {Ni 3 (H 2 O)(B-α-PW 9 O 34 )(B-β-PW 8 O 31 )} 2 ] 21− is composed of two {Ni 3 (H 2 O)(B-α-PW 9 O 34 )(B-β-PW 8 O 31 )} 12− subunits linked by three Na + ions. And each {Ni 3 (H 2 O)(B-α-PW 9 O 34 )(B-β-PW 8 O 31 )} 12− subunit is composed of two nonequivalent Keggin fragments, [B-β-PW 8 O 31 ] 9− and [B-α-PW 9 O 34 ] 9− held together via three Ni 2+ ions. A new 1D network architecture is built up of the adjacent sandwich polyanions [Na 3 (H 2 O) 8 {Ni 3 (H 2 O)(B-α-PW 9 O 34 ) (B-β-PW 8 O 31 )} 2 ] 21− through two Na + ions. The electrochemical behavior is elucidated in the pH = 5 (0.2 M Na 2 HPO 4 + NaH 2 PO 4 ) buffer solution employing cyclic voltammetry. Two reversible redox peaks correspond to the redox of the W VI . An investigation of the magnetic property indicates that the six nickel centers exhibit dominantly ferromagnetic exchange interaction. more...
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- 2011
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30. O31. Age-Normative Pathways of Striatal Connectivity Relate to ADHD Symptoms in the General Population
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Todd Lencz, Katherine H. Karlsgodt, Christina L. Fales, Anita D. Barber, Deepak Sarpal, Majnu John, and Anil K. Malhotra
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education.field_of_study ,Population ,Normative ,Adhd symptoms ,education ,Psychology ,Biological Psychiatry ,Clinical psychology - Published
- 2018
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31. O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink
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Lorna Clarson, Edward Roddy, Christian D Mallen, Samantha L Hider, John Belcher, and Carl Heneghan
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Clinical Practice ,medicine.medical_specialty ,Discrete time and continuous time ,business.industry ,Event (relativity) ,Physical therapy ,medicine ,Medical emergency ,medicine.disease ,business ,Survival analysis ,Gout - Published
- 2015
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32. O31. Comparison of thyroid image quality for pinhole and parallel hole collimators: A phantom study
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D. Potgieter
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Physics ,Cold spot ,Image quality ,business.industry ,Detector ,Biophysics ,General Physics and Astronomy ,Collimator ,General Medicine ,Imaging phantom ,law.invention ,Optics ,law ,Radiology, Nuclear Medicine and imaging ,Pinhole (optics) ,Human thyroid ,business ,Gamma camera - Abstract
Introduction Developing countries often have limited funds and thus diagnostic and treatment modalities should be operated in a cost effective manner while maintaining proper patient care. Gamma camera collimators are acquired at additional cost and the pinhole collimator is often more expensive than the more commonly used Low-energy-high-resolution (LEHR) collimator. The aim of this study was to compare the image quality of a pinhole and parallel-hole collimator using a thyroid phantom. Materials and Methods The thyroid phantom is a perspex block of 10 × 10 cm with thickness of 3 cm. It contained a cavity of an average human thyroid with one hot spot and three cold spots of different sizes and locations. A defect was placed on the phantom at different locations and 53 MBq Tc-99m was injected into the phantom and imaged using the following imaging protocols; (i) clinical protocol as specified by the manufacturer, (ii) equivalent count densities for the pinhole and parallel hole, (iii) equivalent zoom factor for both collimators, (iv) variable detector to phantom distance for the parallel hole collimator. The images were assessed for defect detectability, contrast and sensitivity using human observers. Results All the observers could find the defect for all imaging protocols when the pinhole collimator was used, while in the case of the parallel hole collimator this was only possible when the detector to phantom distance was decreased. The pinhole collimator had superior contrast to that of the parallel hole collimator. As expected the sensitivity of the pinhole collimator was less than that of the parallel hole collimator. Conclusion From this study it is evident that the image quality of the pinhole collimator is superior to the parallel-hole collimator and therefore acquiring a pinhole collimator for thyroid imaging on the gamma camera is justified. more...
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- 2016
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33. O31 Engaging Aboriginal and Torres Strait Islander communities
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M. McDonald
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Infectious Diseases ,Geography ,Torres strait ,Epidemiology ,Virology ,Immunology ,Public Health, Environmental and Occupational Health ,Ethnology ,Public aspects of medicine ,RA1-1270 ,Microbiology ,QR1-502 - Published
- 2017
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34. Structure of the O-polysaccharide of Proteus penneri 28 and Proteus vulgaris O31 and classification of P. penneri 26 and 28 in Proteus serogroup O31
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Anna N. Kondakova, Sof'ya N. Senchenkova, Krystyna Zych, Yuriy A. Knirel, Alexander S. Shashkov, Beata Bartodziejska, Zygmunt Sidorczyk, and Antoni Rozalski
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Microbiology (medical) ,Lipopolysaccharides ,Immunology ,Proteus vulgaris ,Molecular Sequence Data ,Microbiology ,Proteus penneri ,Epitope ,Residue (chemistry) ,Acetic acid ,chemistry.chemical_compound ,Immunology and Allergy ,Humans ,Serotyping ,Nuclear Magnetic Resonance, Biomolecular ,biology ,O Antigens ,General Medicine ,biology.organism_classification ,Proteus ,Enterobacteriaceae ,Bacterial Typing Techniques ,Infectious Diseases ,chemistry ,Carbohydrate Sequence ,Bacteria - Abstract
The lipopolysaccharides (LPS) of Proteus penneri 28 and Proteus vulgaris O31 (PrK 55/57) were degraded with dilute acetic acid and structurally identical high-molecular-mass O-polysaccharides were isolated by gel-permeation chromatography. Sugar analysis and nuclear magnetic resonance (NMR) spectroscopic studies showed that both polysaccharides contain D -GlcNAc, 2-acetamido-2,6-dideoxy- L -glucose ( L -2-acetamido-2,6-dideoxyglucose (N-acetylquinovosamine)) and 2-acetamido-3-O-[(S)-1-carboxyethyl]-2-deoxy- D -glucose (N-acetylisomuramic acid) and have the following structure: Download : Download full-size image where (S)-1-carboxyethyl [a residue of (S)-lactic acid] (S-Lac) is an ether-linked residue of (S)-lactic acid. The O-polysaccharide studied is structurally similar to that of P. penneri 26, which differs only in the absence of S-Lac from the GlcNAc residue. Based on the O-polysaccharide structures and serological data of the LPS, it was suggested classifying these strains in one Proteus serogroup, O31, as two subgroups: O(31a), 31b for P. penneri 28 and P. vulgaris PrK 55/57 and O31a for P. penneri 26. A serological relatedness of the LPS of Proteus O(31a), 31b and P. penneri 62 was revealed and substantiated by sharing epitope O31b, which is associated with N-acetylisomuramic acid. It was suggested that a cross-reactivity of P. penneri 28 O-antiserum with the LPS of several other P. penneri strains is due to a common epitope(s) on the LPS core. more...
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- 2003
35. [O31] Estimating metastable phase formation during magnetron sputtering
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Dennis Lange, Denis Music, Hamid Bolvardi, Keke Chang, Jochen M. Schneider, and Moritz to Baben
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Materials science ,General Chemical Engineering ,Metastability ,General Chemistry ,Atomic physics ,Sputter deposition ,Phase formation ,Computer Science Applications - Published
- 2015
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36. Ionic Conductivity and Thermal Structure Stability of α-A Na3 [PMo9 O31 (H2 O)3 ]·13H2 O
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Makoto Watanabe, Makoto Sakurai, Kenichi Imaeda, Eri Ishikawa, Yuji Hayashi, and Yasushi Miyata
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Materials science ,Chemical substance ,Analytical chemistry ,Stability (probability) ,law.invention ,Keggin structure ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Magazine ,law ,Thermal ,Magic angle spinning ,Ionic conductivity ,Science, technology and society - Published
- 2012
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37. Genetic variation of capsule/LPS biogenesis in two serogroup O31 Vibrio cholerae isolates
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O. Colin Stine, Judith A. Johnson, Yuansha Chen, and J. Glenn Morris
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Molecular Sequence Data ,medicine.disease_cause ,Microbiology ,Gene cluster ,Genetic variation ,Genetics ,medicine ,Homologous chromosome ,Serotyping ,Molecular Biology ,Gene ,Vibrio cholerae ,Bacterial Capsules ,Phylogeny ,Base Composition ,biology ,Base Sequence ,Genetic Variation ,biology.organism_classification ,Virology ,Vibrio ,Diarrhea ,Genes, Bacterial ,medicine.symptom ,Sequence Alignment ,Biogenesis - Abstract
Both NRT36S and A5 are NAG-ST-producing, serogroup O31 Vibrio cholerae. NRT36S is encapsulated and causes diarrhea when administered to volunteers; A5 is unencapsulated and does not colonize or cause illness in humans. The capsule/LPS (CPS/LPS) biogenesis regions in these two isolates were similar except that a 6.5-kb fragment in A5 has replaced a 10-kb fragment in NRT36S in the middle of the CPS/LPS gene cluster. Although the genes of the replaced region were homologous to genes from other CPS/LPS, they had little similarity to NRT36S and were not homologous to genes from other Vibrios. Data of this study highlight the apparent mobility within the CPS/LPS region that would provide a basis for the large number of observed V. cholerae serogroups and the emergence of novel epidemic strains. more...
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- 2007
38. O31: Score de qualité nutritionnelle des aliments de la Food Standard Agency (FSA) dans le contexte alimentaire français : catégorisation des aliments par rapport aux recommandations du Programme National Nutrition Santé (PNNS)
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Léopold Fezeu, Mathilde Touvier, Caroline Méjean, Chantal Julia, Emmanuelle Kesse-Guyot, and Serge Hercberg
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Introduction et but de l’etude Les profils nutritionnels des aliments attribuent un score de qualite nutritionnelle aux aliments en fonction de leur composition en macro- et micro nutriments. Ils peuvent servir de support au developpement d’actions de sante publique, dont un systeme d’information nutritionnelle complementaire (propose dans le rapport Hercberg, 2014), afin d’orienter les choix des consommateurs. L’objectif de ce travail etait d’etudier la coherence entre le score de qualite nutritionnelle developpe par la FSA (score FSA) et la classification les aliments consommes en France selon les recommandations du PNNS. Materiel et methodes Les donnees de la table de composition de l’etude NutriNet-Sante (N = 3331 aliments solides et N = 177 boissons) ont ete utilisees afin de calculer le score FSA des aliments, a partir de leur teneur (pour 100g) en energie, sucres simples, acides gras satures, sodium, proteines, fibres et leur pourcentage en fruits, legumes et noix. Ces aliments ont ete categorises selon les groupes alimentaires du PNNS. L’ensemble des aliments presents dans la table de composition a ete divise en quintiles pour les aliments solides, et en quartiles pour les boissons selon la distribution du score FSA. La distribution des aliments dans les quintiles/quartiles de score a ete comparee selon les groupes alimentaires du PNNS. Les analyses ont ete realisees avec et sans une ponderation prenant en compte la frequence de consommation des produits dans un echantillon representatif de la population francaise issus de l’etude Nutri-net-Sante (N = 4225 sujets, ayant consomme N= 1878 aliments solides et N = 95 boissons). Resultats et Analyse statistique Les aliments solides avaient des scores FSA allant de - 15 (le plus favorable) a + 32 (le moins favorable). La distribution des aliments dans les quintiles de score FSA etait coherente avec les groupes alimentaires du PNNS : 98 % des fruits et legumes et 90 % des produits cerealiers etaient classes dans les deux premiers quintiles du score FSA. Inversement, 6 % des sauces et matieres grasses et 4 % des produits de grignotage sucres etaient classes dans les deux premiers quintiles. Au sein des groupes alimentaires, des differences de qualite nutritionnelle selon le score FSA apparaissaient : parmi les produits laitiers, 99 % des laits et yaourts etaient classes dans les deux premiers quintiles de score, contre 65 % des desserts lactes, 16 % des glaces et 5 % des fromages ; pour le groupe « Viande poisson œuf », 90 % des poissons, 73 % des viandes etaient classes dans les deux premiers quintiles, contre 9,09 % des charcuteries. Parmi les boissons, les jus de fruits etaient classes a 98 % dans le premier quartile de distribution du score FSA, les boissons non sucrees majoritairement dans le deuxieme quartile et les boissons sucrees a 72 % dans le quatrieme quartile. Conclusion Le score de qualite nutritionnelle de la FSA permet de categoriser les aliments consommes en France de facon coherente avec les recommandations du PNNS, et permettent une differenciation entre aliments d’un meme groupe. Ces resultats confirment que le score de qualite nutritionnelle de la FSA est adapte au contexte alimentaire francais. more...
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- 2014
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39. O31: Comprehensive non-MS drug screening by UPLC-PDA-CAD with durable quantitative calibration
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J. Viinamäki and I. Ojanperä
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Chromatography ,Calibration curve ,Health, Toxicology and Mutagenesis ,010401 analytical chemistry ,Detector ,Extraction (chemistry) ,Analytical chemistry ,Ethyl acetate ,Toxicology ,01 natural sciences ,High-performance liquid chromatography ,0104 chemical sciences ,Photodiode ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,law ,Calibration ,030216 legal & forensic medicine ,Butyl acetate - Abstract
Introduction Mass spectrometric (MS) methods are today widely used in analytical toxicology, but in comprehensive quantitative drug screening it is laborious to maintain quantitative calibration and use of historic calibration is not feasible. In non-MS gas chromatographic (GC) and liquid chromatographic (LC) methods, historic calibration is widely used. However, GC is not amenable to analysis of current polar drugs and traditional LC-UV methods do not have high enough identification power to meet the requirements of screening. Ultra-performance LC (UPLC) with two consecutive detectors appears to possess high potential for simultaneous multi-component screening and quantification. In this study, a comprehensive quantitative screening method for 170 basic drugs in blood samples was developed and validated using UPLC coupled with photodiode array (PDA) and corona charged aerosol detector (CAD). Methods Blood samples were extracted with organic solvent (ethyl acetate: butyl acetate, 25:75) in basic conditions. After extraction, the organic solvent was evaporated to dryness and samples were reconstituted with the UPLC mobile phase. Dibenzepine was used as an internal standard. Chromatographic separation was performed at 60 °C using a HSS C18 column (150 mm × 2,1 mm, particle size 1,8 μm), and the mobile phase consisted of 0.1% trifluoroacetic acid and methanol. After a three minute isocratic phase, a linear gradient from 5% to 95% methanol in 15 minutes followed. The flow rate was 0.4 mL/min. UV spectra were collected in the range of 210–400 nm, and wavelength of 230 nm was used for quantification. Substance identification was based on the UV spectrum, retention times on both detectors, and the response ratio of CAD and PDA at wavelength 230 nm. Calibration was carried out using a single calibration point at the vicinity of the upper limit of therapeutic range of each drug. Individual calibration curves were created for both detectors and the average result was used for quantification. Results The retention times were found be very stable, the relative standard deviation of retention times being Conclusion The developed method allows the detection and quantification of 170 basic drugs in therapeutic and toxic concentrations in a single run. Due to the stability of calibration and good linearity, historic one-point calibration can be utilized. Adding the CAD detector with universal response after the PDA detector increases the reliability of both identification and quantification. In addition, drugs with poor UV absorption can be detected and quantitated. This method provides a tool for comprehensive quantitative screening for ordinary basic drugs in blood and leaves LC-MS target analysis to be applied to low-dose compounds. more...
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- 2014
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40. O31 GENDER DISPARITY AND REAL-LIFE PRACTICE SETTING DIFFERENCES IN ACTUAL TREATMENT OF PATIENTS WITH CHRONIC HEPATITIS B MEETING CRITERIA FOR ANTIVIRAL THERAPY
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Jun Li, Lily H. Kim, V.G. Nguyen, Mindie H. Nguyen, Huy N. Trinh, and J.Q. Zhang
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medicine.medical_specialty ,Hepatology ,Chronic hepatitis ,Practice setting ,business.industry ,Antiviral therapy ,Physical therapy ,Medicine ,business ,Intensive care medicine ,Gender disparity - Published
- 2014
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41. O31 Menses – to test or not to test?: Abstract O30 Table 1
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Janet Wilson, Sarah A Schoeman, and Catherine Mw Stewart
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Gynecology ,medicine.medical_specialty ,Chlamydia ,business.industry ,Confounding ,Reproductive medicine ,Cervicitis ,Dermatology ,During menstruation ,medicine.disease ,Test (assessment) ,Infectious Diseases ,medicine ,Urine sample ,business - Abstract
Background/introduction Varied advice is given to women about testing for chlamydia (CT) and gonorrhoea (NG) whilst menstruating. Some are advised it makes no difference, others are advised not to test or are offered urine sampling instead of a vulvovaginal swab. There is no published evidence to inform such advice. Aim(s)/objectives To determine if menses affects the performance of CT/NG NAATs. Methods Using data collected in a large CT/NG NAATs diagnostic study we compared the prevalence of infections in menstruating women versus those not menstruating. Results Of the 3973 study participants 162 (4%) were menstruating and 3811 were not. 30 (18.5%) menstruating women had CT and 10 (6.2%) had NG; 380 (10%) non-menstruating women had CT and 90 (2.4%) had NG. Menstruating women were more likely to be diagnosed with CT (OR 2.05; p = 0.0008) and NG (OR 2.72; p = 0.0055); less likely to have had a previous STI (OR 0.66) and to have cervicitis (OR 0.21) but more likely to be a STI contact (OR 2.13) and have bacterial STI symptoms (OR 1.36). After adjusting for these confounding variables menstruating women remained more likely to be diagnosed with CT (Adjusted OR 1.98; 95% CI 1.27–3.09; p = 0.003). Discussion/conclusion Menses does not have a negative effect of the performance of CT/NG NAATs; in fact the prevalence of infections was higher in menstruating women. Only 4% of women were menstruating suggesting that women avoid attending for STI testing during their period unless really necessary. Hence testing should be performed during menstruation using vulvovaginal or endocervical swabs. more...
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- 2015
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42. O31 Évolution de la prévalence du diabète traité pharmacologiquement, France, 2006-2013
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N. Regnault, P. Denis, Anne Fagot-Campagna, S. Fosse-Edorh, and Laurence Mandereau-Bruno
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Abstract
Objectif Decrire l’evolution de la prevalence du diabete traite pharmacologique-ment, a partir des donnees de l’Assurance maladie, en France, entre 2006 et 2013. Patients et methodes Les personnes diabetiques traitees, tous regimes d’Assurance maladie confondus, ont ete identifiees dans le Systeme national d’information inter-regimes de l’Assurance maladie (Sniiram), par la delivrance d’antidiabetiques oraux ou d’insuline a au moins trois dates differentes au cours de chaque annee d’etude (deux si au moins un grand conditionnement est delivre). Le taux de croissance annuel moyen (TCAM) global a ete etudie sur la periode 2006-2013 et decline sur la periode 2010-2013 en fonction du sexe, de l’âge, de la region, de la cmU-C et du niveau de desavantage social de la commune de residence. Resultats La prevalence du diabete traite pharmacologiquement en France est estimee a 4,7 % en 2013, tous regimes d’Assurance maladie confondus, soit plus de 3 millions de personnes. En 2006, cette prevalence etait inferieure a 4 %. L’augmentation de la prevalence du diabete observee depuis 2006 enregistre un ralentissement: le TCAM etait de 5,1 % sur la periode 2006-2009, et de 2,4 % sur la periode 2009-2013. Les evolutions temporelles seront detaillees par sous-populations demographiques (sexe, classe d’âge, region, niveau socio-economique) afin d’identifier si les progressions au sein de certaines sous-populations sont differentes de la progression globale. Conclusion La prevalence du diabete ne cesse d’augmenter. Toutefois, cette progression enregistre un ralentissement depuis 2009. L’analyse des evolutions temporelles par sous-populations pourra permettre de mieux cibler les populations dans lesquelles des actions de prevention des risques modifiables (surpoids et obesite, sedentarite) devront etre mises en place. Declaration d’interet Les auteurs declarent ne pas avoir d’interet direct ou indirect (financier ou en nature) avec un organisme prive, industriel ou commercial en relation avec le sujet presente. more...
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- 2015
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43. O31 Étude randomisée contrôlée multicentrique d’une nutrition entérale immuno-modulatrice chez le patient de réanimation ventilé
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François Sztark, Jean Louis Vincent, Jean-Charles Preiser, Jean-François Timsit, J.-F. Zazzo, Laurent Petit, and A.R. van Zanten
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,Medicine (miscellaneous) - Published
- 2013
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44. O31 Impact de l’acide alpha-linolénique dans l’alimentation maternelle sur le développement de la barrière intestinale du porcelet nouveau-né
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F. De Quelen, Jacques Mourot, Stéphanie Ferret-Bernard, and Gaëlle Boudry
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,Medicine (miscellaneous) - Published
- 2011
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45. O31: EEG monitoring for early outcome prediction in patients with postanoxic coma treated with mild therapeutic hypothermia
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Ronald J. Trof, M.J.A.M. van Putten, Jeannette Hofmeijer, Michiel J. Blans, Albertus Beishuizen, and Marleen C. Tjepkema-Cloostermans
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business.industry ,Hypothermia ,Sensory Systems ,Postanoxic coma ,Neurology ,Physiology (medical) ,Anesthesia ,medicine ,In patient ,Neurology (clinical) ,medicine.symptom ,Outcome prediction ,business ,Eeg monitoring - Published
- 2014
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46. O31. An Open Label, Pilot, Multi-Centre, Step-Down, Randomized Controlled Trial to Examine Whether Etanercept 25 mg Once Weekly is Effective in Maintaining a Clinical Response in Patients with Ankylosing Spondylitis who have Responded to 50 mg Once Weekly
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Loretta Dean, Louise Hamilton, Max Yates, Helen Doll, Frances Elender, and Karl Gaffney
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medicine.medical_specialty ,Ankylosing spondylitis ,business.industry ,Once weekly ,medicine.disease ,law.invention ,Etanercept ,Rheumatology ,Randomized controlled trial ,law ,medicine ,Physical therapy ,Pharmacology (medical) ,In patient ,Multi centre ,Open label ,business ,medicine.drug - Published
- 2014
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47. O31 Deux scores de risque génétique sont fortement associés aux variations de glycémie à jeun et à l’incidence d’hyperglycémie et de diabète de type 2 dans l’étude prospective D.E.S.I.R
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B. Balkau, Ghislain Rocheleau, Michel Marre, E. Eury, Loic Yengo, Stéphane Lobbens, Amélie Bonnefond, Philippe Froguel, Olivier Lantieri, and Martine Vaxillaire
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Abstract
Introduction Les meta-analyses d'etudes d'association pan-genomique de cohortes de sujets diabetiques de type 2 et normoglycemiques ont confirme 65 marqueurs genetiques (SNPs) formellement associes au risque de diabete de type 2 (DT2) et 36 SNPs associes aux variations de glycemie a jeun (GaJ). Toutefois, les effets genetiques individuels des alleles-a-risque sont modestes, et n'expliquent qu'une faible part de l'heritabilite du DT2 (~10 %) et de la variance de GaJ (~5 %). Dans l'etude prospective D.E.S.I.R, nous avons teste l'effet de 2 scores de risque genetique (SRG) sur la variation de traits metaboliques, ainsi que sur l'incidence a 9 ans et la prevalence de DT2 et d'hyperglycemie a jeun (HG). Materiels et methodes 65 SNPs associes au DT2 (SRG-1) et 24 SNPs associes aux variations de GaJ (SRG-2 : 65 + 24 SNPs) ont ete genotypes par puce ADN Metabochip (iSelect-Illumina) chez les participants de D.E.S.I.R. Les SRG ont ete analyses chez 4 075 sujets non diabetiques (GaJ Resultats SRG-1 et SRG-2 sont associes a l'augmentation de GaJ (β=0,0011mmol/l/allele/an, p [SRG-1]=8,2×10 -5 et p [SRG-2]=6,0×10 -6 ) et a l'incidence de DT2 ou HG (HR [SRG-1]=1,03, p=4,3×10 -9 ; HR [SRG-2]=1,04, p=1,0×10 -16 ). Ces SRG sont aussi fortement associes a la prevalence finale de DT2 (OR [SRG-1]=1,13, p=1,9×10 -14 ) et DT2 ou HG (OR [SRG-2]=1,07, p=7,8×10 -25 ). Pour chaque SRG, les sujets appartenant au tertile superieur montrent un risque de DT2 significativement plus eleve (HR [SRG-1]=1,97, p=9,1×10 -4 ; HR [SRG-2]=1,71, p=9,5×10 -3 ) comparativement aux sujets du tertile inferieur. Conclusion Notre etude montre que deux SRG modelisant les effets genetiques des alleles-a-risque de DT2 seuls ou combines a ceux associes a l'augmentation de GaJ peuvent identifier les individus les plus a risque de DT2. more...
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- 2014
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48. O31 Effets de l’exenatide versus placebo sur la perte de poids, chez des patients diabétiques de type 2 suivant des mesures hygiéno-diététiques
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C. Salaun-Martin, L. Glass, Yongming Qu, C. Bonnard, Y. Guo, and L. Wolka
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Abstract
Introduction La perte de poids chez les patients diabetiques de type 2 (DT2) est associee a une amelioration du controle glycemique, a une diminution de l'insulino-resistance et des facteurs de risques cardiovasculaires. Pourtant cet objectif reste encore difficile a atteindre pour des patients suivant des mesures hygieno-dietetiques (MHD). Cette etude a pour but de comparer en double aveugle et sur 24 semaines, les effets de l'exenatide (EXE) versus placebo (PBO) sur la perte de poids de patients DT2 obeses ou en surpoids traites par metformine et/ou sulfamides et suivant des MHD. Patients et methodes Les MHD consistent en une diminution de l'apport calorique journalier de 600 kcal et en une augmentation de l'activite physique d'au moins 150 minutes par semaine. Les sujets ont ete randomises en 2 groupes, recevant soit 5 μg d'EXE (n=96), soit le PBO (n=98), 2 fois par jour. Apres 4 semaines d'etude, le traitement est augmente a 10 μg d'EXE, ou a un volume equivalent en PBO. Resultats Au debut de l'etude, les caracteristiques des patients etaient les suivantes (moyenne±SD) : âge : 54,8 ±9,5 ans ; poids : 95,5±16,0 kg ; HbA1c : 7,6±0,8 %. En fin d'etude, les 2 groupes presentaient une augmentation similaire de qualite et de duree d'activite physique ainsi qu'une diminution similaire de l'apport calorique. Le groupe EXE, par rapport au groupe PBO, a montre une plus forte perte de poids (− 6,16±0,54 versus − 3,97±0,52 kg, p=0,003), un taux d'HbA1c plus faible (− 1,21± 0,09 versus 0,73±0,09 %, p −4 ), et de meilleures pressions systolique (− 9,25±1,50 versus – 1,73±1,49 mmHg, p versus 0,50±0,97 mmHg, p=0,06). Des cas de nausees ont ete rapportes plus frequemment dans le groupe EXE (44,8 % versus 19,4 %, p −3 ), sans difference concernant le nombre d'abondons suite a des evenements indesirables (4,2 % versus 5,1 %, p=1,0). De plus, aucun cas d'hypoglycemie severe n'a ete rapporte. Conclusion Le traitement par EXE permet une amelioration significative du controle glycemique, de la perte de poids et de la pression arterielle, quand il est combine a des MHD de plus de 24 semaines. more...
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- 2009
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49. O31 Failure of puberty in Egyptian beta-thalassemic patients: experience in North East Region Dakahlia Province
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H. Ghanem and N. Abdelrazik
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Delayed puberty ,Traditional medicine ,business.industry ,Physiology ,Hematology ,Odds ratio ,medicine.disease ,Follicle-stimulating hormone ,Oncology ,Hypogonadotropic hypogonadism ,medicine ,Endocrine system ,medicine.symptom ,Luteinizing hormone ,business ,Body mass index ,Hormone - Abstract
Background: Endocrine complications in thalassemia major (TM) are classically considered to be the result of iron deposition in the endocrine glands. Hypogonadotropic hypogonadism, which still remains the commonest endocrinopathy in patients with TM, has been proven to be the result of hemosiderosis of the gonadotroph cells of the pituitary gland. The aim of the study: To evaluate the prevalence of delayed puberty and hypogonadotropic hypogonadism in transfusiondependent patients with beta-TM. Patient and methods: Growth and sexual development of 40 patients with TM (20 males, 20 females) aged 12–22 years were evaluated. Thirty healthy individuals aged 12–20 years served as a control group. The following parameters were measured in every patient: age, sex, height, weight, body mass index (BMI) and Tanner’s pubertal staging. For all patients, the following investigations were done: ophthalmological evaluation, audiograms, skeletal survey, echocardiography, serum ferritin, liver function tests, hepatitis profile, serum calcium, phosphorus and blood sugar. Thyroid, parathyroid hormones, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T) and estradiol (E2) hormone were also measured. Results: Failure of puberty was present in 80% of boys and 75% of girls aged 12–22 years. Gonadotropin insufficiency was found in most of the patients with lack of puberty. Arrested puberty was noted in five boys (25%) and six girls (30%). Ten girls (50%) did not menstruate, two (10%) had oligomenorrhea, one (5%) had irregular menstrual cycles and two (10%) developed secondary amenorrhea. Using univariate analyses and stepwise logistic regression analysis after adjustment for confounding factors, serum ferritin at the time of the study was identified as an independent risk factor for hypogonadotropic hypogonadism, with an odds ratio of 28.40 (95% confidence interval 3.25–245.15), P 1⁄4 0.003 with a B value of 3.24 (standard error, 1.12). Conclusions: We conclude that failure of puberty is common in our thalassemic patients which necessitates newer protocols of treatment, correct blood transfusion and chelation therapy. more...
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- 2007
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50. O31
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Linda Neuhauser, Rebeccah Rothschild, and Fatima M. Rodriguez
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Nutrition and Dietetics ,Medicine (miscellaneous) - Published
- 2007
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