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Objective Although the etiopathogenesis of preeclampsia (PE) is unknown, evidence suggests that it may be associated with increased oxidative stress. Studies have shown that oxidative stress can affect DNA fragments called telomeres. However, the interactions of PE, oxidative stress, and telomere length are not clearly known. This study aims to evaluate the oxidative/anti-oxidative stress balance in the placenta and umbilical cord and examine the effect of oxidative stress on telomeres. Materials-Method Cord blood and placental samples were collected from 27 pregnant women with severe PE (280/7–336/7 gestational weeks) and 53 healthy pregnant women. Telomere length (TL) was measured by real-time PCR in the cord blood and placenta tissue. Total antioxidant status (TAS) and total oxidant status (TOS) levels were measured in the cord blood and placenta tissue using a colorimetric method. Results No significant differences were found between groups regarding age, BMI, gravida, parity, and newborn gender (p>0.05). Cord blood and placental TL of PE patients were significantly shorter than the control group, while cord blood and placental TAS and TOS levels were higher (p Conclusion This study found that oxidative stress is an independent risk factor in the development of PE and shortens TL in both placental and umbilical cord blood. Future research on telomere homeostasis may offer a new perspective for the treatment of PE.

Aims: We investigated the relationship between novel inflammatory parameters and Psoas:lumbar vertebra index (PLVI) in elderly patients and assessed which parameter would have a stronger relationship with sarcopenia. Method: We retrospectively evaluated the prospective recorded data of patients aged over 65 who were admitted to our hospital between June 2019 and September 2020. We used the PLVI calculated using the cross-sectional area of the L4 vertebral body and the left and right psoas muscles by using computer tomography, to assess central sarcopenia. Laboratory tests were evaluated, which consisted of white blood cell (WBC), albumin, neutrophils, lymphocytes, hemoglobin, C-reactive protein, platelets, Neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR). Results: Six hundred and eleven patients (351 females and 260 males) with a mean age (and standard deviation) of 73.7 ± 6.8years were included in this study. Statistically significant relationships were found between age and PLVI. Patient age was also significant correlated with albumin, platelets, lymphocytes, hemoglobin, and NLR. Statistically significant relationships were found between gender and PLVI. Gender was also significant correlated with albumin, platelets, lymphocytes, hemoglobin, and NLR. Psoas:lumbar vertebral index was significantly correlated with platelets and hemoglobin. Conclusion: According to our results, the inflammatory panel, which included NLR, PLR, CRP, and WBC, were not significantly associated with low PLVI in elderly Turkish people. Central sarcopenia was detected especially in elderly and female participants. Although the inflammatory markers were not associated with sarcopenia, platelet and hemoglobin levels were observed to be significantly correlated with sarcopenia.

Bilindiği gibi Hz. Peygamber ile ilgili olarak kaleme alınan siyer ve mevlidler başta olmak üzere bütün eserlerin ortak konularından biri de Mi'râc'tır. Yüzyıllardan beri dünyanın farklı coğrafyalarında ve değişik dillerde Efendimiz ve O’na duyulan aşk ve mahabbet ile ilgili manzum, mensur binlerce eser yazılmıştır. Dinî tasavvufî Türk edebiyatının en derin ve bereketli konularından biri de budur. “Mekke’de Muhammed (s) Türkistan’da Ahmed” ifadesiyle tanınan Ahmed Yesevî’den beri edib ve şairlerimiz Mi’râc ile ilgili olarak kendilerine ulaşan bilgileri hayal güçleriyle süsleyerek bu muhteşem olayı müminlerin imanlı gönüllerine aktarmanın yollarını aramış bulmuşlardır. Bir müddet sonra bu şiirlerin bestelenmesiyle daha başka bir güzellik ortaya çıkmış, mûsikînin gönül tellerini okşayan meltemi esmeye başlamış, bir başka ifade ile insan sesi ve nefesi ile Peygamber aşkı ve şevki bir araya gelmiştir.

Objective: The aim was to evaluate the possible effects of anti-angiogenic factors including soluble endoglin (sEng), placental growth factor (Pgf), and soluble fms-like tyrosine kinase 1 (sFlt-1) in both normotensive pregnant patients and preeclampsia (PE) patients. Material and Methods: The study was carried out at the Departments of Gynecology and Obstetrics and Biochemistry of Yozgat Bozok University Training and Research Hospital. Eighteen women with PE who were pregnant for at least 20 weeks comprised the study group. The control group consisted of 33 pregnant women with no complications and with similar demographic features. In the study, laboratory parameters, demographic characteristics, sEng, sFlt-1, and Pgf levels, delivery type, APGAR scores of the infants, and birthweight were determined and a comparison was made between the groups. Results: It was found that the sEng level was significantly lower in the PE group compared to the control group (p

Bu araştırmada, laiklik ilkesine bağlı iki farklı ülkede, başörtüsüyle ulusal meclislere ilk kez seçilen iki kadın siyasetçinin, bu ülkelerin ulusal yazılı medyalarında nasıl görüldüklerinin belirlenmesi amaçlanmıştır. Araştırma, örnek olay araştırması şeklinde tasarlanmış, Türkiye’den Merve Kavakcı’nın 1999’da Türkiye Büyük Millet Meclisi’ne seçilmesi ve Amerika Birleşik Devletleri’nden Ilhan Omar’ın 2018’de Senatör seçilmesi ardından bu olayların her iki ülkenin ulusal yazılı medyalarına yansımaları örnek olay öğeleri olarak ele alınmıştır. Dolayısıyla, Merve Kavakcı ve Ilhan Omar olayları araştırmanın sınırlarını oluşturmaktadır. Araştırma kapsamındaki, her iki ülkenin ulusal yazılı medyalarında yer alan haberler belge incelemesi yöntemiyle incelenmiştir. Aynı zamanda, günümüz Türkiye Büyük Millet Meclisi’nde grubu bulunan siyasi partilerin önde gelen bazı üyeleriyle görüşmeler yapılarak, Merve Kavakcı ve başörtüsüyle siyaset konularındaki görüşlerine başvurulmuştur. Belge incelemesi ve görüşme yöntemleriyle ulaşılan veriler, belirlenen tema ve kodlara göre organize edilerek içerik analizi tekniğiyle çözümlenmiştir. Kodlamalarda ve bulguların görselleştirilmesinde nitel analizler için geliştirilen, Maxqda Programı’ndan yararlanılmıştır. Sonuçta, Merve Kavakcı olayının Türk ulusal yazılı medyasında ağırlıklı olarak laiklik ilkesine aykırılık, karşı devrimcilik, kışkırtma, Amerikan ajanlığı şeklinde; Ilhan Omar olayının ise, Amerikan ulusal yazılı medyasında ağırlıklı olarak ırk/siyahi, Müslüman kadın ve mülteci kavramları üzerinden görüldüğü anlaşılmıştır. Yine, Türkiye Büyük Millet Meclisi’nde, halihazırda siyaset yapan partilerin önde gelen üyelerinin, kadınların başörtüleriyle Mecliste siyaset yapabilmeleri konusuna 1999 Merve Kavakcı olayına göre daha ılımlı yaklaştıkları tespit edilmiştir.

Senay Cetinkaya,1 Burcu Turkoglu,2 Emra Dogan,2 Mustafa Kara3 1Child Health and Diseases Nursing, Department of Nursing, Çukurova University, Adana, Turkey; 2Health Sciences Institute, Çukurova University, Adana, Turkey; 3Af&scedil;in Health College, Kahramanmara&scedil; Sütçü Imam University, Kahramanmara&scedil;, TurkeyCorrespondence: Senay Cetinkaya, Faculty of Health Sciences, Department of Nursing, Child Health and Diseases Nursing, Çukurova University, Adana, 01130, Turkey, Tel +90322 388 64 84, Fax +90322 338 69 70, Email senayg_202@hotmail.comBackground and Purpose: The aim of this study was to investigate the knowledge level of nurses and midwives about the level of knowledge about neonatal resuscitation and the effect of education on knowledge levels.Methods: The research was applied in January 2016 to the nurses and midwives who worked in neonatal intensive care units, gynecology and maternity wards at Cukurova University Balcal&inodot; Hospital, Adana Numune Training and Research Hospital, Adana Maternity and Children Diseases Hospital, and had received Neonatal Resuscitation Program practitioner training course. All of the target populations were included in the research before the sample was determined. Data were collected using a questionnaire form consisting of 40 questions including sociodemographic information and knowledge level related to NRP.Results: It was determined that the nurses and midwives answered the questions correctly related to oxygen usage (98.1%) and all the things that should be conducted in order to prevent heat loss in baby (98.1%). It was determined that NRP knowledge points of nurse/midwives were intermediate level as 23.06 ± 3.47 (min: 12; max: 30) and most of the participants (37%) had got NRP course in the last 4– 5 years. There was a statistically significant difference between participating time to NRP practitioner training course and working years (p < 0.05).Implications for Practice: Systematic repetition of knowledge and skills through in-service training programs is important, as it will lead to a reduction of mortalities of newborns.Implications for Research: It was observed that the knowledge points were quite good considering that the participants of the NRP practitioner-training course had taken the course in the last 4– 5 years.Keywords: education, midwife, neonatal, nurse, resuscitation knowledge level

Din Psikolojisi dünyada olduğu gibi Türkiye’de de hızla gelişen ve araştırmacılar tarafından yoğun ilgi gören bir bilim dalıdır. Bu makalede, Türkiye’de Din Psikolojisi’nin ilk dönem temsilcilerinden olan, son yarım yüzyıla yakın bir zaman diliminde alana pek çok kitap, makale, bildiri, yönettiği tez ve yetiştirdiği öğrencilerle önemli katkılar sunan ve sunmaya da devam eden duayen hocalardan Prof. Dr. Hüseyin Peker’in, Din Psikolojisi’ne katkıları incelenmektedir. Biyografi niteliğindeki bu araştırma, onun eserlerine, onunla ilgili röportajlara, yetiştirdiği bazı öğrencilerin kanaatlerine, alanın bazı hocaları ile yapılan görüşmelere ve literatür taramasına dayanmaktadır. Araştırma, giriş kısmını takip eden iki bölümden oluşmaktadır. Giriş bölümünde; araştırmanın yöntemi, amacı ve önemi yer almaktadır. Birinci bölümde, Hüseyin Peker Hoca’nın hayatı, kitapları, makaleleri ve bildirileri, ikinci bölümde ise, Türkiye’de Din Psikologlarının değerlendirmeleri bağlamında Peker Hoca’nın alana katkıları ele alınmaktadır. Değerlendirme ve sonuç kısmı ile çalışma tamamlanmaktadır. Yapılan araştırma sonucunda, Peker Hoca’nın eserleri, yetiştirdiği öğrencileri ve yönettiği tezlerle, Din Psikolojisi Bilim Dalı’nın gelişmesine, geniş kitlelerce tanınmasına ve sevilmesine önemli katkılar sunduğu görülmüştür.

Introduction: Congenital afibrinogenemia is a rare coagulation disorder characterized by a deficiency in the fibrinogen molecule. Fibrinogen is a hexameric glycoprotein consisting of a polypeptide chain encoded by FGB, FGA, and FGG and is required for normal hemostasis. Changes in FGA, FGB, and FGG may affect fibrinogen at different levels. As a result of these changes, fibrinogen cannot be detected in the blood. Clinical manifestations of such changes range from asymptomatic to life-threatening bleeding or thromboembolic events. Since it is an autosomal recessive disease, the risk is higher in children whose parents are related. Therefore, the disease is more common in regions where consanguineous marriage rates are high. Diagnosis is made by laboratory tests that show the absence of fibrinogen. These patients need to be treated with fibrinogen replacement therapy. Case presentation: This study reports the case of a newborn with congenital afibrinogenemia. The baby born from a first-degree consanguineous marriage was referred to our hospital due to bleeding and ecchymosis, and afibrinogenemia was diagnosed after coagulation tests were performed. Blood samples of the patient and his parents were sent to the Genetic Diseases Diagnosis Center for a genetic diagnosis of afibrinogenemia. A new homozygous mutation of FGB exon 7: c.1220c > t (p.t407 m) (p.thr407 met) was identified in the patient. The patients' parents were heterozygous for the same mutation. Prophylaxis was not recommended for our patient who was asymptomatic in the follow-up. Conclusions: We present the case of a hemorrhagic neonatal patient diagnosed with congenital afibrinogenemia and emphasize that fibrinogen testing should be included in the evaluation of such patients. Furthermore, congenital fibrinogen disorders may be more severe when caused due to unknown specific mutation genes. Therefore, a more center-involved genetic analysis is required to identify undiagnosed fibrinogen and fibrinogen mutations.

The aim of this study is to assess the FNDC5 and myonectin expressions and serum levels of myonectin and irisin in women with PCOS. 90 participants were included in this case-control study. 45 of these participants were with PCOS, and 45 of them were healthy volunteers matched for age and body mass index (BMI). Serum irisin and myonectin levels were measured with commercially available enzyme-linked immune sorbent assay (ELISA) kits. Expression of the myonectin and FNDC5 genes were determined by RT-PCR analysis. It was found out that FSI, HOMA-IR, LH, LH/FSH, TT, serum irisin and serum myonectin levels, myonectin mRNA expression, and FNDC5 mRNA expression were higher in the PCOS group, whereas HDL-C level was lower in the PCOS group (

Objective: This study aimed to define the rare Brucella infection in pregnancy and its effects on immunoglobulins (Ig). Materials and Methods: This prospective study has conducted Brucella screening using the Rose Bengal test on pregnant and non-pregnant outpatients who did not show any specific Brucella symptoms. The immunoglobulin levels were measured using the enzyme-linked immunosorbent assay. The study group consisted of pregnant women who were at 20 weeks or below gestation and applied to our hospital outpatient clinic for routine check-ups. The control group consisted of healthy patients who applied for routine controls. Results: This study included a total of 584 participants, 293 of whom were controls and 291 were the study (pregnant) participants. The study revealed a 1.5% incidence of Brucella during pregnancy. In acute and chronic Brucella infection, lower levels of IgA response were observed in pregnant cases compared to the control group. Conclusion: Brucella infection is a disease that can cause fetal problems, especially in endemic areas. The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology. Objective: This study aimed to define the rare Brucella infection in pregnancy and its effects on immunoglobulins (Ig). Materials and Methods: This prospective study has conducted Brucella screening using the Rose Bengal test on pregnant and non-pregnant outpatients who did not show any specific Brucella symptoms. The immunoglobulin levels were measured using the enzyme-linked immunosorbent assay. The study group consisted of pregnant women who were at 20 weeks or below gestation and applied to our hospital outpatient clinic for routine check-ups. The control group consisted of healthy patients who applied for routine controls. Results: This study included a total of 584 participants, 293 of whom were controls and 291 were the study (pregnant) participants. The study revealed a 1.5% incidence of Brucella during pregnancy. In acute and chronic Brucella infection, lower levels of IgA response were observed in pregnant cases compared to the control group. Conclusion: Brucella infection is a disease that can cause fetal problems, especially in endemic areas. The role of the altered IgA response in pathologies that are associated with Brucella infection stands out as a new target for disease pathophysiology.

BACKGROUND/AIM Necrotizing enterocolitis (NEC) is one of the most important causes of morbidity and mortality in premature infants. Although there are no specific diagnostic tools, the main factors affecting prognosis are clinical and laboratory findings, and early diagnosis and treatment. In this study, we demonstrate the importance of dual-energy computed tomography (DECT) in confirming intestinal ischemia in neonates with NEC. MATERIALS AND METHODS Patients diagnosed with NEC in a neonatal intensive care unit were staged according to modified Bell?s classification, and DECT was performed on patients with NEC stages 2-A, 2-B and 3-A. According to their DECT reports, these patients were then separated into two groups: those with intestinal ischemia and those without intestinal ischemia. The patients with intestinal ischemia were evaluated using surgical reports, and the other patients were evaluated using clinical findings. RESULTS DECT was performed in 21 patients with NEC stages 2-A, 2-B and 3-A. Twelve patients (57.1%) without ischemia were followed up without surgery. Nine patients (42.9%) with ischemia on DECT were operated on, and resection and anastomosis or ileostomy and colostomy were performed. CONCLUSIONS In patients with NEC, DECT significantly increases overall diagnostic confidence in assessing intestinal necrosis when compared with traditional diagnostic methods.

Prenatal subdural hematoma is a rare condition and causes death or neurological impairment in newborns. The etiology of subdural hematoma is still controversial, but trauma is seen most important reason. In this disease, a multidisciplinary study is required, which includes gynecology, neurosurgery, neonatology, and radiology. We presented a newborn with prenatal subdural hematoma who we operated a treated in a multidisciplinary way.

The examination of the mining engineering profession from the perspective of female engineers and the investigation of the profession in terms of gender equality constitute the main scope of this study. This study also aims to identify and offer solutions to the problems based on sexist roles faced by female mining engineers in Turkey who have studied mining engineering and are currently practising their profession. In this context, a field study was conducted based on the views of 103 participants. In the study, a digital questionnaire consisting of two parts was distributed to the participants. In the first part of the questionnaire, demographic information was asked, and in the second part, questions about the gender-based evaluation of female engineers' professions were asked. Solution suggestions were presented by evaluating and interpreting the data obtained from the study., Bu çalışmada, Dünya’da ve Türkiye’de halen erkek egemen bir alan olarak kabul edilen maden mühendisliği mesleğine kadın mühendislerin perspektifinden bakarak mesleğin toplumsal cinsiyet eşitliği yönünden irdelenmesi hedeflenmiştir. Bu çalışma, Türkiye’de maden mühendisliği eğitimi almış ve hali hazırda mesleğini icra eden kadın maden mühendislerinin, mesleklerini icra ederken cinsiyetçi rollere dayalı olarak karşılaştıkları sorunları tespit etmeyi ve çözüm önerileri sunmayı amaçlamaktadır. Bu bağlamda, 103 katılımcının görüşlerine dayalı olarak bir saha çalışması gerçekleştirilmiştir. Çalışmada katılımcılara iki kısımdan oluşan bir dijital anket dağıtılmıştır. Anketin ilk kısmında demografik bilgiler, ikinci kısmında ise kadın mühendislerin mesleklerini toplumsal cinsiyete dayalı olarak değerlendirmelerine ilişkin sorular sorulmuştur. Çalışmadan elde edilen veriler değerlendirilerek ve yorumlanarak çözüm önerileri sunulmuştur.

BACKGROUND In this study, we evaluated to the relationship between the type of accessory navicular bone (ANB) and radiological parameters of foot in patients with bilateral ANB of different types. METHODS Patients with bilateral ANB of different types participated in this study, from May 2019 to April 2020. Patient data, including age, sex, body mass index (BMI), and presence of symptoms were obtained. We aimed to compare the radiological parameters of both the feet for evaluate the differences from one another in patients with bilateral ANB of different types (one side type 1 and contralateral side type 2) because the foot angles may differ in each person. Seven radiographic parameters were measured, including calcaneal pitch angle, talocalcaneal angle, tibiocalcaneal angle, naviculocuboid overlap, talonavicular coverage angle, anteroposterior talo-first metatarsal angle, and the lateral talo-first metatarsal angle, which evaluated hindfoot, midfoot, and forefoot alignment. RESULTS Twenty patients (13 women and 7 men) with a mean age (and standard deviation) of 38.5 {plus minus} 12.3 years were included in the study. The patients had a mean height of 168.1 {plus minus} 7.1 cm, a mean weight of 77.2 {plus minus} 10.5 kg, and a mean BMI of 27.4 {plus minus} 4.3 kg/m2. There was no significant difference between type 1 and type 2 in all radiological parameters. There was no significant correlation between radiological parameters and age, BMI, or the presence of symptoms. CONCLUSIONS We found that the type of ANB had no effect on the radiological measurements of the foot in which we evaluate the parameters patients with bilateral ANB of different types. Additionally, age, BMI, and the presence of symptoms, also demonstrated no correlation with the radiological parameters of the foot.

Purpose: Preeclampsia (PE) is a pregnancy-specific syndrome characterized by placentation disorder that increases maternal and fetal morbidity and mortality. Overproduction of anti-angiogenic factors such as soluble fms-like tyrosine kinase receptor 1 (sFlt-1) and soluble endoglin (sEng) and low production of placental growth factor (Pgf) from angiogenic factors contribute to preeclampsia pathogenesis. In this study, factors involved in angiogenesis including sEng, Pgf and sFlt1 were investigated for pre-recognition of preeclampsia. Methods: A total of 54 pregnant women were included in the study and the patients were divided into normotensive (n = 25) and preeclampsia groups (n = 29). Both groups demographic characteristics, laboratory parameters, sEng, sFlt1 and placental growth factor levels were compared. Results: While AST, uric acid, LDH mean values were significantly higher in the study group compared to the control group (p

İktidar ilişkileri kavramı sadece siyaset biliminde değil sosyal bilimlerin tamamında merkezi bir konuma sahiptir. Kavram, farklı kuramlarda benzer terimlerle açıklansa da bu terimlere yüklenen anlamlar temelden tartışmalı bir zeminde yükselmektedir. İktidarın ne olduğu, nerede olduğu, nasıl işlediği ve hangi sonuçları ürettiğine dair görüşler keskin farklılıklar göstermektedir. Bu çalışmada, mikro ve makro seviyelerde, sınırlayıcı ve üretken iktidar kavramsallaştırmalarında kullanılan güç, kuvvet, şiddet, meşruiyet, otorite, baskı, dominasyon, nüfuz, zorlama, ve manipülasyon gibi terimlerin kurumsalcı ya da davranışsalcı yaklaşımlardaki tanımlarına yer verilmiştir. Çalışmada açıklanan teorisyenler sırasıyla Max Weber, Hannah Arendt, Talcott Parsons, Robert Dahl, Peter Bachrach ve Morton Baratz, Steven Lukes ve Michel Foucault’dur. Çalışma, iktidarın sosyal veya bireysel partiklerden türediğini savunan kuramların farklılıklarına odaklanmıştır. Kuramlardaki farklılıkları gösteren bir başka boyut, iktidarın bireyin ya da sosyal bedenin bir özelliği olduğuna ilişkin kabuldür. İktidarın, aktörlerin çatışmalarında ortaya çıktığını savunan yaklaşımların yanı sıra bir çatışma olmadan manipülasyon yoluyla işleyebileceğini öne sürenler de vardır.

In this paper, we define new higher order Kantorovich-type Szász–Mirakjan operators, we give some approximation properties of these operators in terms of various moduli of continuity. We prove a local approximation theorem, a Korovkin-type theorem, and a Voronovskaja-type theorem. We also prove weighted approximation theorems for these new operators.

شرّف الله تعالى البشرية بالقرآن الكريم، الكتاب المعجز، الذي سخّر له الله تعالى الكثير من العلماء على مدى العصور لخدمته والحفاظ عليه، والذي كان سببَا في نشوء الكثير من علوم اللغة؛ لتفسيره وبيان علومه، ومن تلك العلوم علم النحو والإعراب، الذي اعتُبِر من أهم علوم اللغة العربية التي ساهمت في كشف وبيان أسرار اللغة العربية، ومفتاحًا لفهم معاني القرآن الكريم، ومعرفة إعجازه، وتذوّق حلاوة معانيه، وهذا كان من أسباب سعي الكثير من العلماء القدماء والمتأخّرين لتحصيل هذا العلم الذي يُعتَبَر هو الأصل في علوم اللغة العربية، والذي يرتكز عليه العلماء في فهم علوم الشريعة الإسلامية، والقرآن الكريم. وموضوع البحث هو الحديث عن الصلة بين علم النحو والإعراب وبين تفسير القرآن الكريم، والذي تمثَّل بإيضاح المعاني، وإظهار الفوارق بينها، وكذلك إزالة المبهم منها لفهم آيات القرآن الكريم بشكلٍ صحيح، كما ساهم في تفسير الآيات القرآنية بأكثر من وجه، والذي دلّ على الإيجاز الذي اتّسم به أسلوب القرآن الكريم؛ حيث أعطى معانٍ عديدة من خلال آية واحدة، وكان هذا من أدلّة إعجاز القرآن الكريم. وقد ألّف الكثير من العلماء القدامى والمحدثين كتبًا حول العلاقة بين علم النحو ومعاني القرآن الكريم، والذي كان هدفها فهم كتاب الله، وإزالة ما ورد في بعض آياته من غموضٍ وإشكال، وكان لهذه الكتب دورٌ في ظهور التفسير بالرأي؛ الذي اعتمد أصحابه على إعمال العقل في تفسير القرآن الكريم، بما لا يعارض النقل الشرعي واتباعه، فنشأ التفسير بالرأي نتيجة اجتماع التفسير اللغوي مع التفسير بالمأثور. كما تأثر بذلك المحدثون من العلماء الذين اعتمدوا على معاني النحو في إيجاد وجوه جديدة لمعاني الآيات القرآنية، ومن أبرزهم في هذا العصر فاضل السامرائي الذي عرض في كتبه آراء العلماء القدامى، وناقشها للتوصل إلى وجه جديد لمعنى الآية بما لا يتعارض مع النقل الشرعي. وهنا تبرز أهمية الموضوع في أنّ للنحو دورًا في إثراء المعاني التفسيريّة وتنوّعها في الآية الواحدة، مما يدلّ على مدى تأثير الإعراب في المعنى، ومدى احتياج المفسّر لمعرفة علم النحو والإعراب. فما مدى علاقة علم النحو بتفسير القرآن؟ وهل للنحويين دورٌ في تعدّد معاني القرآن الكريم؟ وهل اهتمّ المفسرون القدماء بعلم النحو؟ وأيّ نوعٍ من أنواع التفسير كان لعلم النحو دورٌ فيه أكثر من غيره؟ وما مدى تأثير علم النحو في ظهور التفسير بالرأي؟ وما أهمية علم النحو للمفسرين والدارسين لعلم التفسير؟ يتمّ مناقشة هذه الأسئلة من خلال هذه الدراسة ويتم اتباع المنهج الوصفي والتاريخي لدراسة نشأة علم النحو وعلاقة ذلك بعلم التفسير، ويتم ذلك بدءًا من القرن الأول الهجري إلى القرن الخامس، ثم المحدثون، وبعد ذلك يتمّ تحليل المعلومات ومناقشتها للوصول إلى نتائج مقبولة؛ ومن أهمها اعتبار العلماء علم النحو من العلوم التي يجب أن يُلمَّ بها المفسِّر؛ لأنَّه يُعتبر من أهم الوسائل لتفسير وفهم آيات القرآن الكريم، واستخلاص أحكامه، بالإضافة إلى أنّ فهم آيات القرآن الكريم تتوقّف على مدى معرفة المفسِّر بعلوم اللغة العربية التي نزل بها، وأهمها علم النحو، وبدون تلك العلوم قد يبتعد عن الطريق الصحيح لتفسير القرآن الكريم.

Objective: The aim of this study was to assess the diagnostic values of new biochemical markers that may be an alternative to the oral glucose tolerance test (OGTT) and determine the differences in these markers among three groups of women with varying degrees of glucose homeostasis dysregulation. Material and Methods: This was a prospective study. All women were screened with 50 gram (g) oral glucose and a 100 g OGTT for gestational diabetes mellitus (GDM). The patients were divided into three groups depending on the result of the tests: no evidence of glucose metabolism abnormality (controls); impaired glucose tolerance (IGT); and GDM. All three groups were evaluated for serum human advanced glycation end-products (AGEs) concentrations, carboxymethyl lysine (CML) concentration and receptor for advanced glycation end-product concentrations (RAGE/AGER), body mass index (BMI), age, fasting glucose levels, obstetrical parameters and gestational age. Results: The study included 180 women divided into 59 (32.8%) GDM, 50 (27.8%) IGT and 71 (39.4%) controls. Age was similar among the three groups. Whereas fasting glucose levels and BMI in the three groups was significantly different, AGEs, CML, RAGE/AGER levels were found as significantly different between the groups (p

AIM Ovarian torsion is a gynecopathology that requires emergency surgery in women. However, ischemia reperfusion injury (IRI) occurs after treatment with detorsion. This study aimed to evaluate the effects of monoacylglycerol lipase inhibitor JZL184 on ovarian IRI and ovarian reserve. METHODS Forty-eight female Wistar albino rats were divided into six groups. Group 1: Sham, Group 2: Ischemia, Group 3: ischemia/reperfusion (IR), Group 4: IR + JZL184 4 mg/kg, Group 5: IR + JZL184 16 mg/kg, Group 6: IR + vehicle (dimethyl sulfoxide). Three hours of ischemia followed by 3 h of reperfusion. Two different doses of JZL184 (4 and 16 mg/kg) were administered intraperitoneally in Group 4 and 5, 30 min before reperfusion. Ovarian IRI and ovarian reserve were evaluated in serum and tissue by using histopathological and biochemical parameters. RESULTS Treatment with JZL184 was associated with a significant increase in ovarian 2-arachidonoylglycerol and improved serum anti-Mullerian hormone, Inhibin B, primordial follicle count, and ovarian histopathological damage score (p

Amaç: Patoloji sonucu uterin leiomyom olarak sonuçlanan vakaların, yapılan cerrahi işlem, myom özellikleri ve eşlik eden patolojiler açısından değerlendirilmesi hedeflenmiştir. Ayrıca; myom sayısı, büyüklüğü ve lokalizasyonuna göre inflamatuar belirteçlerin de değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Cerrahi sonrası patoloji sonucu uterin leiomyom olarak değerlendirilen 102 hastanın verileri retrospektif olarak değerlendirildi. Olguların yaş, gravida, parite, preoperatif ve postoperatif hemogram sonuçlarına hasta dosyalarından ulaşıldı. Myoma eşlik eden diğer jineko-patolojiler, myom boyutu, sayısı ve yerleşimi bilgilerine patoloji raporlarından ulaşıldı.Bulgular: Myom yerleşimi incelendiğinde olguların %44.1’inin intramural yerleşim gösterdiği, myom sayısına bakıldığında ise hastaların %61’ inde en az iki adet myom olduğu saptandı. Hastalara yapılan cerrahi işlemler retrospektif değerlendirildiğinde olguların %46’sına total abdominal histerektomi yapıldığı görüldü. İnflamatuar parametrelerle myom büyüklüğü arasındaki ilişki incelendiğinde; ≤5 cm ile ˃5 cm myomu olan olgular karşılaştırıldığında nötrofil/lenfosit oranı ve lenfosit/monosit oranı değerleri istatistiksel olarak anlamlı farklı bulundu (sırasıyla, p=0.023; 0.038), ancak platelet/lenfosit oranı değerleri istatistiksel olarak anlamsız bulundu (p˃0.05). Hem myom boyutu hem de sayısı açısından incelenen olguların preoperatif ve postoperatif hemoglobin değerleri arasında istatistiksel olarak bir farklılık saptanmadı (p˃0.05).Sonuç: Artmış myom sayısı ile lenfosit/monosit oranında azalma gözlenirken, myom boyutu artışıyla nötrofil/lenfosit oranında artış ve lenfosit/monosit oranında da azalma olmaktadır.

Aim:To evaluate subclinical inflammatory markers in hyperemesis gravidarum (HEG) cases and to determine the relationship of these markers with the gestational age at delivery and birth weight in pregnant women with HEG.Methods:Fifty-two patients who presented to our hospital between 1 May 2017 and 1 September 2019 with HEG and 60 pregnant women as the control group were included in this retrospectively designed study. The relationship of subclinical inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the lymphocyte-to-monocyte ratio (LMR) with HEG, and their relationship with birth week and birth weight in HEG cases were examined.Results:In HEG cases, NLR and PLR values were higher (p=0.006 and p=0.004, respectively), whereas LMR values were lower (p

The objective of this study is to assess the levels of heavy metals (cadmium, lead, antimony, mercury, and arsenic), which are also called endocrine-disrupting chemicals, and trace elements (chromium-III, chromium-VI, zinc, copper, and selenium) vs. monocyte to HDL ratio among pregnant women with gestational diabetes mellitus (GDM). A total of 112 pregnant women (60 with GDM and 52 healthy women) were included in this case-control study. Analysis of heavy metals and trace elements were performed in inductively coupled plasma mass spectrometer. Heavy metals (cadmium, lead, antimony, mercury, and arsenic), trace elements (chromium-III, chromium-VI, zinc, copper, and selenium), and metabolic parameters were assessed in both groups. It was determined that the levels of cadmium, lead, antimony, and copper were higher (p 0.05) and levels of chromium-III, zinc, and selenium were lower (p 0.05) among the GDM group compared to the control group, whereas there was a statistically insignificant difference between the two groups, regarding the levels of copper, mercury, and arsenic (p 0.05). Moreover, the monocyte to HDL ratio was higher in the GDM group (p 0.05), and the insulin resistance was significantly higher as well (p 0.05). The results of our study demonstrated that environmental factors could be effective in the etiology of GDM. Toxic heavy metals, through inducing Cu, OS, and chronic inflammation, and other trace elements, either directly by impacting insulin secretion or through weakening the body's antioxidant defense system, could play a role in the occurrence of GDM.

Bu araştırmada, ilk olarak Türkiye’de, Çanakkale ili örneğinde, termik santral projelerinin ÇED süreçlerine projelerden etkilenmesi muhtemel tarafların katılımlarında ne gibi sorunlarla karşılaşıldığının belirlenmesi, ikinci olarak ta ÇED süreçlerine tarafların katılımları konusunda karşılaşılan sorunların giderilmesi noktasında merkezi ve yerel düzeydeki karar vericilere yol gösterici veriler sunulması amaçlanmıştır. Kapsama Çanakkale ilinde yapımı planlanan 18 termik santral projesine ilişkin ÇED süreçleri girmekle birlikte, araştırma Biga İlçesi’ndeki CENAL ve Çan İlçesi’ndeki Çan 2 ve 18 Mart termik santralleri ÇED süreçleriyle sınırlandırılmıştır. Veriler görüşme yöntemiyle toplanmış ve içerik analizi ile çözümlenmiştir. Görüşmelerde 9 sorudan oluşan yarı yapılandırılmış görüşme formları kullanılmış ve toplamda 18 kişi ile görüşülmüştür. Veri analizinde MAXQDA Analytics Pro 18 Programının deneme sürümü kullanılmıştır. Sonuçta, incelenen ÇED süreçlerine katılım konusunda yaşanan sorunlar projeler hakkında akıllardaki soru işaretlerinin ortadan kaldırılamaması, gizlilik gibi gerekçelerle doğru bilgilendirme yapılmaması, yöre sakinlerinin çekincelerinin proje sahiplerince giderilememesi, yöre sakinlerinin görüşlerinin yetkililerce kısmen önemsenmesi ve yöre sakinlerince projelerin yer seçiminin doğru olmadığı şeklinde sıralanmaktadır. Diğer yandan, devlet ve firma yetkilileri dışındaki tarafların projeler hakkında alınan kararlar üzerinde herhangi bir etkilerinin bulunmadığı anlaşılmıştır

الإسرائيليات هي مرويات وردت في المصادر الإسلامية معظمها مأخوذ من اليهودية وقسم منها من المسيحية. ومن هنا نرى أن هناك بعض المعلومات الواردة في التوراة أو الإنجيل؛ لم تذكر أو لم يتم تناولها بالتفصيل في القرآن الكريم. تعتبر بعض هذه المعلومات صحيحة بسبب توافقها مع القرآن الكريم، وبعضها مرفوض لأنه يناقض القرآن الكريم، والبعض الآخر من غير الممكن تحديد صحته أو خطأه. نفهم من ذلك أن المبدأ الأساسي في علم التفسير فيما يتعلق بقبول هذه المرويات هو كونها لا تتعارض مع جوهر الدين أي القرآن الكريم وأمَّا ما يتعارض منها مع جوهر الدّين فلا يؤخذ به. وردت المرويات الإسرائيلية في بعض مصادر الحديث والتفسير القديمة والمراجع المعاصرة. وتختلف مواقف المفسرين القدماء والمعاصرين في قبول ورفض هذه المرويات فبينما يحترم بعض المفسرين المرويات المذكورة لأسباب مختلفة، ينتقدها آخرون بشدة. وبينما مال المفسرون القدماء إلى قبول المرويات المذكورة؛ فإنّنا نُلاحظ أن المفسرين المعاصرين لديهم نظرة ناقدة. كما كانت الانتقادات الموجهة إلى المرويات الإسرائيلية في مصادر التفسير موضوعاً لمجموعة من البحوث العلمية. في هذا السياق تمت محاولة تحديد ما تم إدخاله في التفسير إلى جانب الروايات الصحيحة. ونلاحظ أن العديد من المرويات الإسرائيلية وردت في التفسير، خاصة في تفسير الآيات التي تتحدث عن القصص القرآنية. ومن الملاحظ أن بعض هذه المرويات لا يخالف القرآن الكريم وعصمة الأنبياء.

This is an empirical study aiming to examine the attachment patterns of the fathers who embraced their babies and who did not; and to investigate their participation to the caretaking of their new-...

Intensive research has been conducted on the effects of toxic and trace elements on pregnancy. Previous studies indicated a possible relationship between placental levels of these elements and first-trimester abortion; however, their effects on the further gestational weeks are not clear. This study aimed to investigate the effect of changes in the levels of placental trace and toxic elements on second-trimester abortion.The patient group consisted of 30 women with missed abortion. The control group comprised 60 healthy term and singleton pregnant women who gave birth. Placental samples were obtained from the patients and the healthy controls, and the concentrations of placental elements were measured using inductively coupled plasma mass spectrometry.In the abortion group, placental arsenic, cadmium, mercury, lead, antimony, tin, cobalt, manganese, and selenium levels were significantly higher than those of the control group (p0.05). Antimony was determined as an independent predictor with an odds ratio of 6.1 in toxic elements (p=0.025), and selenium was determined as an independent predictor with an odds ratio of 2.3 in trace elements (p=0.015).The changes in trace element and toxic element levels, especially an increase in antimony and selenium, in placental tissue due to environmental exposure may play an important role in second-trimester abortion.Intensive research has been conducted on the effects of toxic and trace elements on pregnancy. Previous studies indicated a possible relationship between placental levels of these elements and first-trimester abortion; however, their effects on the further gestational weeks are not clear. This study aimed to investigate the effect of changes in the levels of placental trace and toxic elements on second-trimester abortion.The patient group consisted of 30 women with missed abortion. The control group comprised 60 healthy term and singleton pregnant women who gave birth. Placental samples were obtained from the patients and the healthy controls, and the concentrations of placental elements were measured using inductively coupled plasma mass spectrometry.In the abortion group, placental arsenic, cadmium, mercury, lead, antimony, tin, cobalt, manganese, and selenium levels were significantly higher than those of the control group (p0.05). Antimony was determined as an independent predictor with an odds ratio of 6.1 in toxic elements (p=0.025), and selenium was determined as an independent predictor with an odds ratio of 2.3 in trace elements (p=0.015).The changes in trace element and toxic element levels, especially an increase in antimony and selenium, in placental tissue due to environmental exposure may play an important role in second-trimester abortion.

Purpose To compare the rates obtained from hematological parameters in cases of late-onset idiopathic fetal growth restriction (FGR) with healthy pregnancies and to evaluate the effect on neonatal outcomes. Methods The study group consisted of 63 pregnant women with late-onset idiopathic FGR and the control group consisted of 91 healthy pregnant women. The determined rates were calculated from the control hemograms of patients at 28 weeks. Both groups were compared for neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other parameters. Results NLR, leukocyte and neutrophil levels were significantly higher in the FGR group (p0.05). To predict FGR, the best cut-off value of NLR was determined to be 4.11 with 56% sensitivity and 88% specificity values. Conclusion Neutrophil, lymphocyte and platelet interactions have an important role in FGR development. Inflammation can be involved in the etiopathogenesis in late-onset FGR.

Bu makalede, Kur’ân’dan ‘aşır intihâbı/seçimi ve tilâvet esnasında dikkat edilmesi gereken hususlar in-celenmektedir. Araştırmanın amacı, ‘aşrın seçim ve hazırlık aşamasından icra safhasına kadar Kur’ân âyetlerinin, tecvîd kurallarına ve lafızların mana inceliklerine riayet edilerek mûsikî eşliğinde nasıl tilâvet olunması gerektiğini ortaya koymaktır. Araştırma literatür taramasına dayanmaktadır. Çalışmanın alt başlıkları şu şekildedir. i. Kavramsal Çerçeve. Bu başlık altında ‘aşır, tecvîd, temsîl, mûsikî ve tilâvet kavramları ele alınmaktadır. ii. ‘Aşır Tilâveti Öncesi Yapılması Gereken Hazırlıklar. Bu başlıkta, ‘aşrın tespit edilmesi, ‘aşrın ezberlenmesi, ‘aşrın meâlinin okunması, telaffuzu zor kelimelerin önceden çalışıl-ması, vakf ve ibtidâ edilecek yerlerin belirlenmesi, ses vurgusu, raf‘-i savt ve hafd-ı savt yapılacak yerle-rin tespit edilmesi konuları işlenmektedir. iii. ‘Aşrın Tilâveti Esnasında Dikkat Edilecek Hususlar. Bu başlık, tilâvete uygun sesle başlama, tecvîd kurallarına riayet etme ve ‘aşrı tahkîk usulüyle okuma ko-nularına ayrılmaktadır. iv. Temsîlî Tilâvet. Burada temsîlî tilâvette ses vurgusu, raf‘i savt ve hafd-ı savt konuları örnekleriyle birlikte incelenmektedir. v. Kur’ân Tilâveti ve Mûsikî. Bu başlık altında da Kur’ân âyetlerini mûsikî eşliğinde tilâvet etmenin imkânı, Kur’ân ve Sünnet’teki delilleri ışığında tartışılmakta-dır. Netice itibarıyla Kur’ân tilâvetinin insanlık ailesi açısından son derece önemli olduğu, ‘aşır icra et-menin ciddi bir hazırlık gerektirdiği, Kur’ân tilâvetinde tecvîdin vazgeçilmez öneme sahip olduğu, Kur’ân’ı güzel ses ve mûsikî ile okumanın Hz. Peygamber (s) tarafından teşvik edildiği, tilâvet esnasında tecvîd kurallarının mûsikîye kurban edilmemesi gerektiği, ‘aşır okuma esnasında Kur’ân’ın mana ince-liklerinin ancak temsîlî tilâvetle gerçekleştirilebileceği ve başarılı bir tilâvet için fem-i muhsinin rahle-i ted-risinden geçmek gerektiği anlaşılmıştır.

Screening critical congenital heart disease in neonates with 24-48 h of age could be made by oxygen saturation determination. Perfusion index may be used as an adjunct to pulse oximetry screening to detect non-cyanotic critical congenital heart disease cases such as a left heart outflow obstruction. We evaluate the results of combined screening for oxygen saturation and peripheral perfusion index at high altitudes. The study included 501 neonates older than gestational week 35. The mean oxygen saturation was lower than at sea level, and the screening test was positive in a total of 21 (4.2%) babies. Critical congenital heart diseases were not detected in any patient. A total of 10 (2%) babies were detected with PDA, nine (1.8%) of whom recorded a positive screening test. The prevalence of PDA was significantly higher in the positive screening test group when compared with those who underwent echocardiography due to clinical findings.Conclusion: The median peripheral perfusion index at high altitude was not lower than at sea level, while the mean oxygen saturation, in contrast, was lower than at sea level. The low partial oxygen pressure found at high altitudes leads to a variation in postnatal adaptation and an increased prevalence of PDA. Accordingly, oxygen saturation screening may serve to identify babies with PDA at high altitudes. What is Known: • Oxygen saturation is known to be low at high altitudes, and thus the rates of false positivity are high when screening for critical congenital heart disease. • High altitudes are also associated with an increased prevalence of simple congenital heart disease. What is New: • The peripheral perfusion index at high altitude is not lower than at sea level. • The prevalence of PDA is significantly higher in those with false positive screening results.

Bumakalede “Kur’ân-ı Kerîm’in Tesettüre Bakışı” konusu işlenmektedir. Makaleninamacı, Yüce Allah’ın (cc) bir emri olan tesettür hakkında Kur’ân merkezli biranaliz yapabilmek ve bu konuda güncel bir duyarlılık oluşturmaktır.Araştırmanın temel hipotezi, tesettürün Kur’ân’ın en önemli emirlerinden birisiolduğu, ancak bu konuda uygulamaya yönelik bazı aksaklıların yaşandığıdır. Buhipotez, tesettür konusuna Kur’ân merkezli yaklaşmanın önemini de ortayakoymaktadır. Makalenin kapsamı, Kur’ân’da yer alan tesettürle doğrudan ilgiliâyetlerle sınırlı tutulmaktadır. Araştırmanın yöntemi, literatür taramasınadayanmaktadır. Bu doğrultuda, sözü edilen âyetler ışığında Hz. Peygamber’in (s)hadisleri, tefsir külliyatında yer alan bilgiler ve yapılan diğer çalışmalarsentezlenerek değerlendirilmektedir.Makale,Giriş kısmını takip eden dört alt başlıktan meydana gelmektedir. Bu altbaşlıklar şunlardır: i. Kavramsal Çerçeve. Bu başlık iki alt başlıktanoluşmaktadır. a. Tesettür Kelimesinin Etimolojik Yapısı. b. Kur’ân’daTesettürle İlişkili Kavramlar. Bu başlık altında libâs, hımâr/humur, sevb/siyâbve cilbâb/celâbîb kavramları ele alınmaktadır. ii. Kur’ân’da Tesettürle İlgiliÂyetlerin Tahlili. Bu kapsamda, A‘râf Sûresi 26-27, Nûr Sûresi 30-31, 60, AhzâbSûresi 33 ve 59. âyetler araştırmaya konu olmaktadır. iii. Tesettüre BürünmeninAmaçları. Bu doğrultuda tesettürün, takvâ elbisesine bürünmek, edep yerlerinigizlemek, süslenmek, şeytan ve taraftarlarının saldırılarına karşı tedbirliolmak, gözleri harama bakmaktan sakındırmak, namus ve iffeti korumak, ziynetiteşhir etmemek, Yüce Allah’ın emrine itaat etmek, tanınmak, sözlü ya da fiilitacize uğratılmamak, güzel görünmek, soğuktan ve sıcaktan korunmak gibiamaçları olduğu anlaşılmaktadır. iv. Tesettüre Uygun Elbisenin Taşıması GerekenNitelikler. Tesettüre uygun elbisenin takvâya uygun olmak, temiz olmak, insanınvücudunu/tenini göstermeyecek şekilde kalın olmak, vücut hatlarını teşhiretmeyecek düzeyde geniş olmak, kadın elbisesi erkek kıyafetine, erkek kıyafetide kadın elbisesine benzememekgibi nitelikler taşıması gerektiğianlaşılmaktadır., Whatthe Qur’an says about veiling is discussed in this article. The aim of thisarticle is to analyze the veiling, which is a command of Almighty Allah, basedon the Qur’an, and to create a current sensitivity. The basic hypothesis of theresearch is that the veiling is one of the most important orders of the Qur'an,but there are some disruptions to the practice. This hypothesis reveals theimportance of approaching the Qur'an to the Qur'an-centric approach. The scopeof the article is confined to verses in the Qur’an concerning veiling. Themethod of research consists of the literature review on the veiling.Accordingly, and in the light of afore-mentioned verses, Prophet Muhammad’ssayings, relevant data existed in the tafsir works and other works done on thesubject are evaluated. Thearticle includes the four sections following its introduction. Thesesub-headings are as follows. i. Conceptual Framework. ii. The Analysis of theVerses Regarding the Veiling in the Qur’an. The surahs al-Araf (26-27), an-Nur(30-31, 60) and al-Ahzab (33, 59) regarding the veiling in the Qur’an arehandled. iii. The Purpose of the Veiling. It is inferred that the veiling haspurposes such as wearing the piety clothing (taqwa), covering the private partsof the body, protection from the attacks of the satan and its followers,refraining from the illicit glance, protecting the honor and chastity, notrevealing women’s adornment, obeying Almighty Allah’s command, protecting womenfrom being harassed verbally and physically, looking beautiful and protectingwomen from hot and cold weather as part of the purpose of the veiling. iv. TheFeatures of the Cloth in accord with the Veiling. It comes to light thatclothing should be in accord with the taqwa, clean, thick enough not to showthe body, loose not to display the shape of the body and female clothing mustnot resemble the male’s clothing within the context of subhead ‘features of thecloth in accord with the veiling.

Introduction:There is no regional study presenting the pediatric intoxication cases followed in pediatric intensive care units (PICUs). As they show regional features, we aimed to present the pediatric intoxication cases followed in our PICU, and indicate our self-constituted protocol about the PICU admission rules in these patients.Methods:Demographic, clinical and laboratory data of patients who admitted with intoxication and followed in PICU between October 2015 and October 2017 were noted. PICU admission indications were evaluated.Results:Twenty-four (14%) of the 171 intoxication cases formed the study group. Fourteen (58.3%) were female. Ten cases (41.7%) were under 5 years old, 6 (20.8%) were 5-12 years and 8 (37.5%) were over 12 years. In first group, all intoxications were by accident. In second, intoxications were due to accident (n=3), during drug use in treatment dose (n=2) and as a result of child abuse (n=1). In last group, it was by accident in 2, but as a result of suicide in 6 cases. Active ingredients were; central nervous system drugs (n=9), plant (atropa belladona) (n=3), decongestant drugs (n=3), multiple drugs (n=4), intoxication by inhalation (n=1) and other drugs (n=4). Fifteen patients (62.5%) had clinical indications for PICU admission. In five (20.8%) the poison control center advised PICU admission. In four patients (16.7%) we decided PICU admission because of the fatal nature of the ingested drugs.Conclusion:Our results suggest that every clinic, by taking their availabilities into account, should form its own protocols for PICU admission for pediatric intoxication cases.

In this study, a novel decentralized authentication model is proposed for establishing a secure communications structure in VoIP applications. The proposed scheme considers a distributed architecture called the blockchain. With this scheme, we highlight the multimedia data is more resistant to some of the potential attacks according to the centralized architecture. Our scheme presents the overall system authentication architecture, and it is suitable for mutual authentication in terms of privacy and anonymity. We construct an ECC-based model in the encryption infrastructure because our structure is time-constrained during communications. This study differs from prior work in that blockchain platforms with ECC-Based Biometric Signature. We generate a biometric key for creating a unique ID value with ECC to verify the caller and device authentication together in blockchain. We validated the proposed model by comparing with the existing method in VoIP application used centralized architecture.

Polylactic acid (PLA) is a biodegradable non-toxic, biocompatible polymer used as a popular filament material in biomedical applications with the advance of 3D printing technologies. PLA is considered a suitable implant material due to its contribution to bone regeneration. In this study, the use of PLA in Total Hip Arthroplasty (THA) as a liner material was assessed. In this regard, the PLA liner with different material combinations in THA was examined to provide evidence for its potential. The hip implant prototypewas drawn using a computer-aided design tool then transferred into a commercial finite element analysis (FEA) software. The prototypesconsisted of assemblies of PLA with titanium, chrome cobalt, stainless steels, dense NiTi shape-alloys, and Alumina-Zirconia. Simulations were run under static loading conditions. To evaluate and compare the results for the optimum design; factor of safety, total deformation and von Mises stress analysis were used. The results show that Co-Cr implemented implants produce the highest factor of safety. When Al-Zi combined with PLA, it produced least deformation and reasonable von- Mises stress values. PLA might perform best when used with Al-Zi. As a next step, experimental pre-clinical tests are planned to assess the clinical potential.

Numerous studies have been carried out on depression and sexual dysfunction concomitant with polycystic ovary syndrome (PCOS). Increasing evidence has revealed the importance of inflammation in the etiology of PCOS. In addition, it has been known that some neuromodulators affect depression and sexual function. However, their effects on PCOS are not known. This study aimed to evaluate the relationship of depression and sexual function with cytokines and neuromodulators in PCOS patients. The present study included 20 fertile and 30 infertile patients diagnosed with PCOS and 30 healthy volunteers. Metabolic and endocrine parameters, interleukin (IL)-1β, IL-6, TNFα, γ-aminobutyric acid (GABA), Glutamate, Brain-derived neurotrophic factor (BDNF) serum levels, Beck Depression Index (BDI) and Female Sexual Function Index (FSFI) scores of the patients were compared between the groups. TNFα, IL-1β, IL-6, glutamate, GABA, and BDI scores were found to be significantly higher (p < 0.05) in the PCOS group (p < 0.05). Glutamate, TNFα, IL-1β, and IL-6 values were higher whereas GABA and BDNF values were lower in pateints with moderate and severe depression (p < 0.05). There were no statistically significant relationships between these parameters and the FSFI scores (p > 0.05). Multivariate logistic regression analysis was conducted with potential factors that may affect sexual dysfunction. The results indicated that high waist-to-hip ratio (WHR) (> 0.80) with an odds ratio of 1.81 in PCOS patients, and body mass index (BMI) with an odds ratio of 2.3 and high WHR (> 0.80) with an odds ratio of 1.97 in all patients were found to be independent risk factors affecting sexual dysfunction. The results of the present study suggested that chronic low-dose inflammation seen in PCOS may interact with some neuromodulators, leading to the development of depression. However, no relationship was found between these parameters and sexual function. © 2020 Elsevier Ltd

Objective: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. Materials and Methods: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. Results: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p

Deepwater wells possess a high risk of sand escaping the reservoir into the production systems. Sand production is a common operational issue which results in potential equipment damage and hence product contamination. Excessive sand erosion causes blockage in tubulars and cavities in downhole equipment (subsea valves, chokes, bends etc.), resulting in maintenance costs for subsea equipment that adds up to millions of dollars yearly to operators. In this work, a scalable Machine Learning (ML) model readily accessing historical and real-time feed of sensor and simulation data is built to develop a predictive solution. Deployed workflow can inform Control Room Operators before significant damage occurs. An anomaly detection architecture, a common unsupervised learning framework for maintenance analytics, is deployed. Anomaly detection models include methods within the scope of dimensionality reduction. Principle Component Analysis (PCA) and Long Short-Term Memory (LSTM) Autoencoders are deployed to tackle the problem through reconstruction of the original input. During the workflow, a threshold is calculated after batch training and passed along with anomaly error scores in real-time. An alarm is triggered once the real-time anomaly score passes the threshold calculated during batch training. ML outputs are streamlined in near real-time to the database. In this study, deployed ML model performance is benchmarked against a GOM Deepwater well where sanding is known to occur often. The ML Model architecture can process data that is captured by OSI PI historian, predict anomalous sanding events in advance, and is shown to be scalable to other wells in GOM. It is noted from this study that streamlined ML architecture and outputs simplify exploratory data analysis and model deployment across Onshore and Offshore Business Units. In addition, sanding stakeholders are notified in advance and can take early mitigative action before significant damage to wellhead or downhole equipment occurs instead of reacting to a possible sanding event offshore. The novelty of the utilized ML algorithm and process is in the ability to predict sanding anomalies in advance through ML batch training, infer prediction values near real-time, and scale to other assets.

Diffracted fields of a plane electromagnetic wave by an aperture that is composed of two half planes placed apart from each other on the same plane, and both located between two lossless isorefractive media are investigated. The half planes have surface resistances that are different from each other. Firstly, initial field is determined by assuming the scatterers do not exist. Total geometrical optics (GO) field is written by taking the geometry of the problem into consideration. Scattered geometrical optics field is obtained by subtracting the initial field from the total geometrical optics field. Secondly, diffracted fields caused by the edges of the two half planes are evaluated by means of the method of transition boundary (MTB). Diffracted fields are evaluated by using the Wiener–Hopf factorization which includes the Malyughinetz function. The split function is employed for the transition from the geometrical optics waves to the diffracted fields. The obtained diffracted fields are plotted for some parameters of the problem.

Objectives Gonadotropin-releasing hormone agonist (GnRHa) could influence the levels of sex hormones and thyroid hormones. The aim of this study was to investigate the effect of GnRHa on thyroid function. Materials and methods The data of the patients were collected from the registrations of July 2014–October 2014. A total of 41 women who underwent one-time IVF cyclus were evaluated in this cross-sectional study. The patients were categorized into two groups according to the serum T3, T4, and TSH levels before and 2 weeks’ after the administration of GnRHa. Results Mean basal TSH and mean TSH levels on hCG day were 1.98 ± 0.77 and 1.75 ± 0.70, respectively. The difference between the two groups was statistically significant (p 3 and T4 levels. Conclusions In conclusion, our results demonstrate that GnRHa led to a decrease on serum TSH level. Serum-free T3 and T4 levels were remained unchanged and this might be due to early measurement of the hormone levels (just 2 weeks later from GnRHa administration).

In the present study, reflected and diffracted fields of an inhomogeneous plane wave obliquely incident on the surface of a perfectly electric conducting (PEC) half plane are evaluated for a two-dimensional case asymptotically and reexamined by considering the different aspects. Obtained results are plotted by Matlab numerically. Relationships between the complex angle of incidence and field intensities, and phase shifts in the fields are noted. Matlab plots are interpreted and compared to the theory for consistence.