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Resumen tomado de la publicación Evaluación del autocuidado en psicólogos: adaptación española de la SCAP. Antecedentes: el aumento de la carga de trabajo al que se han visto sometidos los/as psicólogos/as en los últimos años ha puesto de relieve la importancia del uso de estrategias de autocuidado que permitan a estos profesionales tomar conciencia y controlar su salud. A pesar de la relevancia de estas estrategias, en España no existe un instrumento adecuado para medirlas. Este estudio presenta la adaptación española de la escala de Autocuidado de Psicólogos/as (SCAP). Método: 368 psicólogos/as españoles (Medad = 40.34, DT = 10.50) participaron en el estudio. Primero, obtuvimos evidencias de validez basadas en el contenido utilizando un panel de seis expertos/as. Finalmente, analizamos la dimensionalidad y consistencia interna del instrumento y obtuvimos evidencias de validez en relación con otros constructos. Resultados: la estructura bifactor se ajustó adecuadamente a los datos y la fiabilidad fue adecuada. El autocuidado se asoció con menores niveles de estrés percibido y burnout y mayor satisfacción con la vida. Conclusiones: la versión en español del SCAP es un instrumento fiable y válido que apoya la interpretación de las puntuaciones propuesta para la SCAP sobre las estrategias de autocuidado utilizadas por los/as psicólogos/as españoles. ESP

[SPA] En un gran número de estudios agrarios se utilizan sensores instalados en el suelo para poder conocer el estado en el que se encuentran los cultivos. Sin embargo, la instalación de estos sensores puede ser bastante complicada. Para determinar si la instalación ha sido exitosa, es interesante monitorizar a pie de campo la evolución de las medidas del sensor. La solución propuesta en este trabajo permite integrar el registrador de datos y todos los elementos accesorios en el mismo dispositivo, además de ofrecer un soporte de almacenamiento compatible con todos los sistemas informáticos, como es una tarjeta MicroSD. [ENG] Soil sensors are used in a wide variety of agricultural experiments in order to get information about the environment of the plants under investigation. Nevertheless, the installation of these sensors might be complicated. To determine if the installation was successful, it is useful to monitor the evolution of the sensor measurements. The solution proposed in this work allows to integrate the data logger device and all the required accessories in the same device, in addition to offering an external storage medium such as an MicroSD card. Este trabajo ha sido financiado por el Ministerio de Investigación e Innovación del Gobierno de España (PCIN-2017-091, WaterWorks2015 ERA-NET) y Manuel Forcen agradece la financiación del contrato predoctoral recibido de la Fundación Séneca (20767/FPI/18).

Wearable Cognitive Assistance (WCA) applications present a challenge to benchmark and characterize due to their human-in-the-loop nature. Employing user testing to optimize system parameters is generally not feasible, given the scope of the problem and the number of observations needed to detect small but important effects in controlled experiments. Considering the intended mass-scale deployment of WCA applications in the future, there exists a need for tools enabling human-independent benchmarking. We present in this paper the first model for the complete end-to-end emulation of humans in WCA. We build this model through statistical analysis of data collected from previous work in this field, and demonstrate its utility by studying application task durations. Compared to first-order approximations, our model shows a ~36% larger gap between step execution times at high system impairment versus low. We further introduce a novel framework for stochastic optimization of resource consumption-responsiveness tradeoffs in WCA, and show that by combining this framework with our realistic model of human behavior, significant reductions of up to 50% in number processed frame samples and 20% in energy consumption can be achieved with respect to the state-of-the-art., Comment: 16 total pages. 12 figures, 2 tables, 1 appendix. Main document body by Manuel Olgu\'in Mu\~noz and Vishnu N. Moothedath; appendix by Vishu N. Moothedath and Jaya Prakash Champati; editing and feedback by all authors; funding by James Gross and Mahadev Satyanarayanan. Submitted to IEEE Transactions on Mobile Computing

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Experimental research on wireless networking in combination with edge and cloud computing has been the subject of explosive interest in the last decade. This development has been driven by the increasing complexity of modern wireless technologies and the extensive softwarization of these through projects such as a Open Radio Access Network (O-RAN). In this context, a number of small- to mid-scale testbeds have emerged, employing a variety of technologies to target a wide array of use-cases and scenarios in the context of novel mobile communication technologies such as 5G and beyond-5G. Little work, however, has yet been devoted to developing a standard framework for wireless testbed automation which is hardware-agnostic and compatible with edge- and cloud-native technologies. Such a solution would simplify the development of new testbeds by completely or partially removing the requirement for custom management and orchestration software. In this paper, we present the first such mostly hardware-agnostic wireless testbed automation framework, Ainur. It is designed to configure, manage, orchestrate, and deploy workloads from an end-to-end perspective. Ainur is built on top of cloud-native technologies such as Docker, and is provided as FOSS to the community through the KTH-EXPECA/Ainur repository on GitHub. We demonstrate the utility of the platform with a series of scenarios, showcasing in particular its flexibility with respect to physical link definition, computation placement, and automation of arbitrarily complex experimental scenarios., Comment: 6 pages, 6 figures, demo session paper

Additional file 1. Materials and methods. Additional references. Fig. S1. (A) Viability of sentinel slices from lung tissue explants on Day 7. (B) Effect of PLN-74809 on Smad2 phosphorylation. (C) Dose titration of PLN-74809 on COL1A1 expression. Fig. S2. Dose titration of PLN-74809 on Col1a1 expression in PCLSs prepared from bleomycin-challenged mouse lung. Fig. S3. Antifibrotic effects of dual αvβ6/αvβ1 inhibition in the bleomycin mouse model. (A) Total lung hydroxyproline content and (B) 2H incorporation into lung hydroxyproline in sham-challenged mice and bleomycin-challenged mice treated with vehicle or PLN-74809. Fig. S4. Concentration required to decrease Col1a1 expression by 50% in PCLSs from acute bleomycin-challenged mouse lung. Table S1. Donor history for human lung samples. Table S2. Custom fibrosis gene panel. Table S3. TaqMan primers/probes.

EUROfusion Consortium 633053

Article number 112706 The SMall Aspect Ratio Tokamak (SMART) device is a new compact (plasma major radius Rgeo≥0.40 m, minor radius a≥0.20 m, aspect ratio A≥1.7) spherical tokamak, currently in development at the University of Seville. The SMART device has been designed to achieve a magnetic field at the plasma center of up to Bϕ=1.0 T with plasma currents up to Ip=500 kA and a pulse length up to τft=500 ms. A wide range of plasma shaping configurations are envisaged, including triangularities between −0.50≤δ≤0.50 and elongations of κ≤2.25. Control of plasma shaping is achieved through four axially variable poloidal field coils (PF), and four fixed divertor (Div) coils, nominally allowing operation in lower-single null, upper-single null and double-null configurations. This work examines phase 2 of the SMART device, presenting a baseline reference equilibrium and two highly-shaped triangular equilibria. The relevant PF and Div coil current waveforms are also presented. Equilibria are obtained via an axisymmetric Grad-Shafranov force balance solver (Fiesta), in combination with a circuit equation rigid current displacement model (RZIp) to obtain time-resolved vessel and plasma currents. Feder (UE) US-15570 Feder (UE) IE17-5670 Horizonte 2020 (Unión Europea) 805162

EUROfusion Consortium 633053

Supplemental material, sj-docx-1-anp-10.1177_00048674211025711 for Incidence and risk factors of mental disorders in the elderly: The European MentDis_ICF65+ study by Sylke Andreas, Holger Schulz, Jana Volkert, Jonas Lüdemann, Maria Dehoust, Susanne Sehner, Anna Suling, Karl Wegscheider, Berta Ausín, Alessandra Canuto, Michael J Crawford, Chiara Da Ronch, Luigi Grassi, Yael Hershkovitz, Manuel Muñoz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Shalev, Kerstin Weber, Hans-Ulrich Wittchen and Martin Härter in Australian & New Zealand Journal of Psychiatry

El confinamiento como medida preventiva ante la COVID19 ha supuesto un alto coste emocional y psicológico a la población en general y especialmente a las personas mayores. Resulta relevante la promoción de factores asociados a la resiliencia, con objeto de impulsar una gestión emocional y un afrontamiento positivo ante la situación presentada, que permitan generar condiciones afectivas y conductuales favorables para escenarios de futuro entre los miembros de la comunidad que constituyen los centros de mayores. Los recursos expresivos y las técnicas artísticas ofrecen procesos y resultados que fortalecen los factores resilientes. Ofrecemos la experiencia de trabajo con títeres empleados como objeto intermediario orientados a la promoción de la resiliencia y del clima relacional existente en los centros de mayores por motivo del confinamiento. Se toma en consideración la importancia del proceso de elaboración, los resultados obtenidos y la difusión de ambos aspectos en ámbitos externos a los centros de mayores. Se trataba de poner en valor el desarrollo de la actividad y el uso del títere como una herramienta de comunicación tanto a nivel interno (mayor-mayor y mayor-cuidador) como a nivel externo, en la relación establecida con colectivos y agentes externos a los centros de mayores. Confinement as a preventive measure against COVID19 has entailed a high emotional and psychological cost to the general population and especially to the elderly. The promotion of factors associated with resilience is relevant, in order to promote emotional management and positive coping in the face of the situation presented, which allow generating favorable affective and behavioral conditions for future scenarios among the members of the community that constitute the elderly centers. Expressive resources and artistic techniques offer processes and results that strengthen resilient factors. We offer the experience of working with puppets used as an intermediary object aimed at promoting resilience and the relational climate that exists in centers for the elderly due to confinement. The importance of the elaboration process, the results obtained, as well as the dissemination of both aspects in areas outside the centers for the elderly are taken into consideration, both in what speaks of the enhancement of the elderly in the development of the activity undertaken, such as with regard to the use of the puppet as a communication tool already internally between the elderly and their caregivers, as in the relationship established with groups and agents external to the elderly centers.

Este trabajo tiene por objeto proponer una clasificación del texto científico-técnico basándose en un enfoque multidireccional. Para llegar a esta clasificación resulta necesario definir previamente este tipo de texto, así como delimitar sus características. Una vez establecido que el discurso científico-técnico, considerado un registro del lenguaje, debe versar sobre los conocimientos procedentes de la observación y el estudio de la realidad (las ciencias) o sobre la aplicación de esos conocimientos (las tecnologías), analizamos y cotejamos los diferentes criterios clasificadores (el código, la temática, el destinatario, la intencionalidad, el género, el canal), con la intención no sólo de realizar una ordenación en función de cada criterio, sino también de determinar cuáles de ellos son los más adecuados para llegar a una tipología de los textos científico-técnicos que resulte de gran utilidad para abordar con más facilidad y con cierto rigor científico el estudio de este tipo de discurso.

En este trabajo estudiaremos el cálculo exterior, una herramienta muy importante de la Geometría Diferencial que es muy útil en Relatividad General. El objetivo será llegar a las ecuaciones de estructura de Cartan, que sirven para calcular la curvatura del espacio-tiempo mediante el cálculo exterior sin coordenadas. Para llegar a las ecuaciones de Cartan, iremos haciendo un repaso de todos los conceptos necesarios para llegar hasta ellas, desde los elementos más básicos, como las variedades topológicas, hasta las herramientas más desarrolladas, como el producto exterior y la diferencial exterior, ambas pertenecientes al cálculo exterior. Como la Geometría Diferencial es una materia muy extensa, iremos mostrando los resultados más importantes que nos lleven directamente al siguiente escalón hacia las ecuaciones de estructura de Cartan. Lo que queremos conseguir con este trabajo es hacer una primera toma de contacto con la Geometría Diferencial y el cálculo exterior más que un estudio detallado de dichas disciplinas, así que no se hará demostraciones rigurosas de los resultados. Sí mostraremos algunos de los cálculos más básicos en los anexos, que servirán de ejemplo de cómo trabajar con los tensores y las herramientas más importantes del cálculo exterior. Como aplicaciones a Relatividad General, mostraremos cómo es el procedimiento a seguir para calcular la curvatura de una variedad pseudo-Riemanniana a partir de las ecuaciones de Cartan, dado que el espacio-tiempo de la Relatividad General es una variedad pseudo-Riemanniana. Haremos los cálculos para diferentes métricas, algunas de ellas utilizadas para modelizar la curvatura del espacio tiempo.

[SPA] Este documento muestra una explicación detallada acerca de una nueva técnica, basada en machine learning, que permite a un ordenador detectar de forma automática la fase fenológica de un árbol de un cultivo de cítricos usando una cámara estándar. Esta técnica ayudará en la aplicación automática de técnicas de riego deficitario. [ENG] This document shows a detailed explanation about a new machine learning-based technique which allows a computer to detect automatically the phenological stage of a citrus crop tree from a picture taken using a standard camera. This will help autonomous systems to determine when deficit irrigation could be applied. Este trabajo ha sido financiado por el Ministerio de Investigación e Innovación del Gobierno de España (PCIN-2017-091, WaterWorks2015 ERA-NET) y Manuel Forcen agradece la financiación del contrato predoctoral recibido de la Fundación Séneca (20767/FPI/18).

Universidad de Sevilla PP2016-7145 EUROfusion Consortium 633053

Article number 112683 A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system. Feder (UE) IE17-5670 Feder (UE) US-15570 Horizonte 2020 (Unión Europea) 633053

In Cartagena de Indias, the «boli» is a popular soft drink, packed in a plastic bag and consumed frozen. One of the most desirable includes as an ingredient the popular soft drink Kola Román, mixed with milk; it's a drink created in 1885 by the family of Soledad Román, wife of Rafael Núñez. In February 2019, an advertising poster announcing the sale of kola pens with milk, hung on a window, on the facade of the Rafael Núñez House Museum in Cartagena de Indias, was forcibly taken from its place by a neighbor of the El Cabrero neighborhood. For the creation of the poster, there was a creative and intellectual exercise that sought to put history and culture in dialogue under the premise of the «sociological turn», which as of June 2018 determines the character of the educational and cultural activities in the House Museum, and that collects postulates of the sociology of culture developed by Pierre Bourdieu. The research seeks to illustrate the operation of the sociological turn by studying how the temporary exhibition «Here bolis are sold» to identify tensions in users regarding the status that the Rafael Núñez House Museum deserves. En Cartagena de Indias, el boli es un refresco popular, envasado en una bolsa plástica y que se consume congelado. Uno de los más apetecidos incluye como ingrediente la popular bebida gaseosa Kola Román, mezclada con leche; esta es una bebida creada en 1885 por la familia de Soledad Román, esposa de Rafael Núñez. En febrero de 2019, un cartel publicitario que anunciaba la venta de bolis de kola con leche, colgado en una ventana, en la fachada de la Casa Museo Rafael Núñez en Cartagena de Indias, fue arrebatado a la fuerza de su lugar por una vecina del barrio El Cabrero. Para la creación del cartel, existió un ejercicio creativo e intelectual que buscó poner en diálogo historia y cultura bajo la premisa del «giro sociológico», que a partir de junio de 2018 determina el carácter de las actividades educativas y culturales en la Casa Museo, y que recoge postulados de la sociología de la cultura desarrollados por Pierre Bourdieu. La investigación busca ilustrar el funcionamiento del giro sociológico estudiando como caso la exposición temporal «Aquí se venden bolis» para identificar las tensiones en los usuarios respecto al estatus que la Casa Museo Rafael Núñez les merece.

Additional file 4 : Supplementary Figure 4: Immunophenotyping of leukocyte populations in the baseline sample of responders and non-responder patients. (A-D) Analysis of the indicated leukocyte subtypes in the baseline blood sample of the patients stratified according to their clinical response. The percentages of the main leukocyte subtypes (A), CD4+ and CD8+ T cells (B), monocyte subtypes (C) and DC subtypes (D) are shown.

[SPA] El aumento de la tensión por el uso de agua, la creciente escasez hídrica y la ocurrencia de eventos climáticos que destruyen infraestructura de riego en períodos críticos de los cultivos, hacen pertinente evaluar la sensibilidad de pomelo frente a diversos escenarios de disponibilidad hídrica, por ello se realizó un ensayo en una finca comercial de pomelos ‘Star Ruby’ en plena producción para evaluar el efecto de la supresión del riego durante el crecimiento del fruto sobre la producción, calidad y comportamiento post recolección. Los tratamientos aplicados fueron: (i) un control (CTL), regado para mantener los valores de potencial hídrico de tallo (Ψtallo) a mediodía en torno a -1 MPa; dos tratamientos de estrés hídrico, en los que se regaron como CTL, excepto (ii) IS II, durante los días 82 y 127 días desde máxima floración (DDMF), correspondientes a la fase II de crecimiento del fruto, y (iii) IS III, durante los días 180 y 262 DDMF, correspondientes a la fase III de crecimiento del fruto , en los que se suprimió el riego hasta alcanzar un umbral de Ψtallo en torno a -2,5 MPa. La integral de estrés hídrico obtenida para cada tratamiento fue de 26.8 y 13.6 MPa día-1 para IS II y III, respectivamente, no pudiéndose generar un similar nivel de estrés para ambos tratamientos. La supresión de riego permitió obtener un ahorro de agua de riego en torno al 20 % sin afectar negativamente a la producción ni a la calidad, exceptuando que los frutos del IS III presentaron una concentración de sólidos disueltos mayor, en torno a un 7%, y una tendencia de sus frutos a adquirir un color amarillo. El comportamiento post recolección fue similar entre tratamientos, aunque los frutos sometidos a supresión de riego durante fase II presentaron una ligera mayor firmeza a los 60 días después de la recolección. [ENG] The increase of tension for the use water, water scarcity and the occurrence of climatic events that destroy irrigation infrastructure in critical periods of crops phenology, make it relevant to evaluate the sensitivity of grapefruit against various scenarios of water availability, so a trial was conducted in a commercial farm of grapefruit 'Star Ruby' in full production to assess the effect of irrigation suppression during the growth of the fruit on production, quality and post harvest behavior. The treatments applied were: (i) a control (CTL), irrigated to maintain midday stem water potential values (Ψstem) around -1 MPa; two water stress treatments, in which they were irrigated as CTL, except (ii) IS II, during the days 82 and 127 days from maximum flowering (DFMF), corresponding to phase II of fruit growth, and (iii) IS III, during the days 180 and 262 DFMF, corresponding to phase III of fruit growth, in which irrigation was suppressed until reaching a threshold of Ψstem around -2.5 MPa. The integral of hydric stress obtained for each treatment was 26.8 and 13.6 MPa day-1 for IS II and III, respectively, not being able to generate a similar level of stress for both treatments. Irrigation supression allowed to obtain a saving of irrigation water around 20% without affecting negatively the production and quality, except that the fruits of IS III presented a higher concentration of dissolved solids, around 7%, and a tendency of its fruits to acquire a yellow color. Post-harvest behavior was similar between treatments, although fruits subjected to irrigation suppression during phase II showed a slightly higher firmness 60 days after harvest. Esta investigación fue realizada en el marco del proyecto REUSAGUA del Plan Estratégico de la Región de Murcia 2014-2020 (IRIS 2020) y el Fondo Europeo de Desarrollo Regional (FEDER).

Additional file 2: Online supplemental Table 2. Regression analysis of the socio-demographic, mental and physical disorders on WHODAS II and WHO-QoL Bref (adjusted for age group, sex (and interaction if significant) as well as study centre)

Additional file 2 : Supplementary Figure S2: Flow cytometry gating strategy for Treg cells. Representative gating strategy used in Treg cell immunophenotyping based on the exclusion of dead cells, the selection of the lymphoid cells by size and complexity, and then the surface expression of CD3, CD4, CD25, CD127, CCR4, HLA-DR and CD45RO markers. After the initial selection of CD4+ T cells (CD3+CD4+), Treg cells were identified as CD25+CD127low double positive cells. The combination of CCR4 and CD45RO markers allowed the identification of naïve Treg (CCR4+,CD45RO−) and memory Treg (CCR4+CD45RO+), whereas HLA-DR positivity identified activated cells in these Treg subpopulations.

Additional file 6 : Supplementary Table 1: Antibodies used for immunophenotyping in peripheral blood.

[SPA] La superficie cultivada de mandarino (Citrus reticulata) representa un 37% de la superficie total de los cítricos en España, que actualmente se cifra en 110.000 ha. La sostenibilidad de la producción de cítricos, en particular, y de la agricultura, en general, se enfrenta a dos desafíos importantes: (i) la fuerte variabilidad en los precios en origen y (ii) el incremento de la escasez de agua. El objetivo principal del trabajo fue evaluar la respuesta agronómica de mandarina ‘Clemenvilla’ a la supresión del riego durante cada una de las fases de crecimiento del fruto, y determinar su sensibilidad al estrés hídrico, de cara a la aplicación de estrategias de riego deficitario controlado. Se establecieron 4 tratamientos de riego: un control (CTL) regado al 120% de la ETc durante todo el ciclo del cultivo y 3 tratamientos de supresión del riego, aplicados durante el final de la fase I e inicio de la II (IS-I), la primera mitad de la fase II (IS-II) y la fase III del crecimiento del fruto (IS-III), comprendidas entre 51 a 100, 76 a 105 y 169 a 240 días después de máxima floración (DDMF), respectivamente. Los ciclos de supresión del riego durante las fase inicial y tardía del fruto permitieron reducir el aporte de agua de riego al 50%, alcanzando una integral de estrés hídrico en torno a 45 MPa día-1, sin afectar a la producción ni a la calidad física del fruto; y en el caso de la supresión durante la fase III de crecimiento del fruto permitió incrementar significativamente la productividad del agua de riego. [ENG] The area cultivated with mandarin (Citrus reticulata) represents 37% of the total of Citrus in Spain, which is currently 110,000 ha. The sustainability of citrus production in particular and of agriculture in general is confronted with two major challenges: (i) the strong variability in prices at origin and (ii) the increase of water scarcity. The main objective of the study was to evaluate the agronomic response of 'Clemenvilla' mandarin to irrigation suppression during each of the fruit growth phases, and to determine its sensitivity to wáter stress, in view of the application of controlled deficit irrigation strategies. Four irrigation treatments were established: a control (CTL) irrigated at 120% of ETc during the whole crop cycle and 3 treatments of irrigation suppression, applied during the end of phase I and beginning of phase II (IS-I), the first half of phase II (IS-II) and phase III of fruit growth (IS-III), ranging from 51 to 100, 76 to 105 and 169 to 240 days after maximum flowering (DAMF), respectively. The irrigation suppression cycles during the initial and late fruit phase allowed reducing the irrigation water use to 50%, reaching an integral of water stress around 45 MPa day-1, without affecting the production or the fruit physical quality; and in the case of suppression during the phase III of fruit growth allowed increasing significantly the irrigation water productivity. Esta investigación ha sido financiada por dos proyectos, uno en el marco del proyecto europeo DIVERFARMING (H2020-RUR-06-2016) a través del Programa Marco Horizonte 2020 de la Unión Europea para investigación e innovación y por el Swiss State Secretariat for Education, Research and Innovation, y otro por la convocatoria de ayudas a Acciones Programación Conjunta Internacional 2017 contempladas en el Programa Estatal de I+D+I orientada a los retos de la sociedad por el Ministerio de Economía, Industria y Competitividad - Agencia Estatal de Investigación (AEI). Referencia: PCIN-2017-091.

Additional file 3 : Supplementary Figure S3: Flow cytometry gating strategy for innate cell populations. Representative example of the gating strategy used for immunophenotyping of the indicated innate subpopulations. After the exclusion of dead cells, monocytes were selected by size and complexity; subtypes were identified by CD14 and CD16 staining, allowing the identification of classical monocytes (CD14+ CD16−), alternative monocytes (CD14−CD16+) and intermediate monocytes. For DC and NK, leukocytes were selected by size and complexity in the live cells, and T- and B-lymphocytes excluded by staining with lineage-specific antibodies. Dendritic cells (DC) and NK cells were selected within the CD20− and CD14− population; NK cells were identified as CD56+ cells (both CD16+ and CD16−) and DC as HLA-DR+CD16− cells. DC subtypes were further defined by CD11c+ (myeloid DC) or CD123+ (plasmacytoid DC).

Additional file 1 : Supplementary Figure S1: Flow cytometry gating strategy for T cells. Representative gating strategy used in T cell immunophenotyping based on the exclusion of dead cells, the selection of the lymphoid cells by size and complexity, and then the surface expression of CD3, CD4, CD8, CCR7 and CD45RA. The combination of these markers allowed the identification of naïve cells (CCR7+CD45RA+), Teff (CCR7−,CD45RA+), TCM (CCR7+CD45RA−), and TEM (CCR7−CD45RA−). Staining with the CD38 marker allowed the identification of activated cells, which were minimally detected only in Teff and TEM subpopulations.

Additional file 1: Online supplementary Table 1. Percentile distribution of the WHODS-II scores

Cells are continuously exposed to different sources of DNA damage agents that can compromise genome stability. Double-strand break (DSB) is one of the most cytotoxic lesions, so faithful repair of DSB is critical to ensure cell viability. Repair of DSBs occurs by direct re-ligation of DNA ends through the non-homologous end-joining (NHEJ) pathway or by the homologous recombination (HR) pathway. Then, cells choose to activate any of these pathways according to their cell cycle progression. The HR pathway repairs the DSBs by using homologous DNA sequence as template for the broken chromosomes. This activity generates joint molecule (JM) intermediates during the different steps of the pathway. JM intermediates are sequentially matured into novel intermediates or dismantled by different specialized proteins (helicases and nucleases) to prevent their progression towards mitosis. Therefore, failure in resolving the JM intermediates results in chromosome segregation defects. Regarding mitochondrial DNA (mtDNA), DNA molecules are constantly damaged as the nuclear DNA and the mtDNA repair process needs to be coordinated with the nucleus activity. For that reason, the majority of the proteins needed for mtDNA repair are imported from the nucleus. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Fondos del presupuesto del Departamento de Biología Molecular y Bioquímica para ayudas a conferencias

Alfvén waves are electromagnetic perturbations inherent to magnetized plasmas that can be driven unstable by a free energy associated with gradients in the energetic particles’ distribution function. The energetic particles with velocities comparable to the Alfvén velocity may excite Alfvén instabilities via resonant wave–particle energy and momentum exchange. Burning plasmas with large population of fusion born super-Alfvénic alpha particles in magnetically confined fusion devices are prone to excite weakly-damped Alfvén eigenmodes (AEs) that, if allowed to grow unabated, can cause a degradation of fusion performance and loss of energetic ions through a secular radial transport. In order to control the fast-ion distribution and associated Alfvénic activity, the fusion community is currently searching for external actuators that can control AEs and energetic ions in the harsh environment of a fusion reactor. Most promising control techniques are based on (i) variable fast-ion sources to modify gradients in the energetic particles’ distribution, (ii) localized electron cyclotron resonance heating to affect the fast-ion slowing-down distribution, (iii) localized electron cyclotron current drive to modify the equilibrium magnetic helicity and thus the AE existence criteria and damping mechanisms, and (iv) externally applied 3D perturbative fields to manipulate the fast-ion distribution and thus the wave drive. Advanced simulations help to identify the key physics mechanisms underlying the observed AE mitigation an EURATOM 633053 Marie-Curie Actions 321455 Ministerio de Economía y Competitividad RYC-2011-09152, FIS2015-69362-P

Patient blood management (PBM) is the timely application of evidence-informed medical and surgical concepts designed to maintain haemoglobin concentration, optimise haemostasis, and minimise blood loss in an effort to improve patient outcomes. The aim of this consensus statement is to provide recommendations on the prevention and treatment of postpartum haemorrhage as part of PBM in obstetrics. A multidisciplinary panel of physicians with expertise in obstetrics, anaesthesia, haematology, and transfusion medicine was convened by the Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis (NATA) in collaboration with the International Federation of Gynaecology and Obstetrics (FIGO), the European Board and College of Obstetrics and Gynaecology (EBCOG), and the European Society of Anaesthesiology (ESA). Members of the task force assessed the quantity, quality and consistency of the published evidence, and formulated recommendations using the system developed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group. The recommendations in this consensus statement are intended for use by clinical practitioners managing perinatal care of women in all settings, and by policy-makers in charge of decision making for the update of clinical practice in health care establishments.

Total hip arthroplasty entails considerable peri-operative blood loss, which may lead to acute post-operative anaemia and red blood cell transfusion. This study was aimed at assessing whether the addition of topical tranexamic acid to our ongoing blood-saving protocol for total hip arthroplasty was effective and safe.A pragmatic, prospective, open-label randomised study of patients scheduled for total hip arthroplasty at a single centre was conducted. Consecutive patients were randomly assigned to receive topical tranexamic acid (2 g) at the end of surgery (tranexamic group, n=125) or not (control group, n=129). A restrictive transfusion protocol was applied. Outcome measures were red blood cell loss at 24 hours after surgery, in-hospital transfusion rate, and incidence of thromboembolic complications.Topical tranexamic acid was effective in reducing both red cell loss (mean difference: 138 mL [95% CI 87-189 mL]; p0.001) in the 24h after surgery and in-hospital transfusion rates (12 vs 32.6%, for the tranexamic acid and control groups, respectively; p0.001; relative risk=0.37 [95% CI 0.22-0.63]). However, relative red cell loss and transfusion rates were higher in females than in males, irrespectively of tranexamic acid use. The beneficial effect of tranexamic acid on transfusion was restricted to patients with pre-operative haemoglobin ≥13 g/dL (5.1 vs 24.8%; p0.001). Topical tranexamic acid was well tolerated and no clinically apparent thromboembolic complications were witnessed.The use of topical tranexamic acid after hip arthroplasty reduced red cell loss and transfusion rates; the efficacy of this strategy may be improved by reinforcing both pre-operative haemoglobin optimisation and adherence to the practice of transfusing single units of red cells.

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-Graduação em Agronegócios, 2018. O presente trabalho analisou os impactos ambientais e socioeconômicos da produção integrada de base ecológica, entendida como aquela que considera tanto a produção vegetal quanto a criação animal na mesma unidade, e que propicia nessas duas atividades ações voltadas para sua sustentabilidade a longo prazo. Para esse fim, em um primeiro momento foram avaliadas três unidades agropecuárias familiares, denominadas “A”, “B” e “C”, localizadas na Região Integrada do Distrito Federal e Entorno (RIDE - DF), às quais foi aplicado o Sistema de Avaliação Ponderada de Impacto Ambiental de Atividades do Novo Rural (APOIA-NovoRural) o qual contempla 62 indicadores integrados em cinco dimensões de sustentabilidade: (a) Ecologia da paisagem; (b) Qualidade dos compartimentos ambientais (atmosfera, água e solo); (c) Valores socioculturais; (d) Valores econômicos e (e) Gestão e Administração. Confirmou-se que para as unidades estudadas a produção integrada de base ecológica ocasionou impactos positivos, uma vez que o Índice de sustentabilidade da atividade, apresentou-se acima da linha de adequação ambiental, estipulada em 0,70 (em uma escala de 0 a 1) para os três casos, assim: A = 0.78; B = 0.75 e C = 0.78. Destacaram-se os desempenhos positivos para as três unidades na dimensão Gestão e Administração (Índices: A = 0.87; B = 0.90; C = 0.87) respaldados pela forte dedicação dos responsáveis com as atividades próprias desse manejo integrado, pelos bons relacionamentos institucionais e, sobretudo, pela gestão e aproveitamento dos recursos das mesmas unidades. Por outro lado, registraram-se desempenhos insatisfatórios para a dimensão compartimentos ambientais, nas características do solo, o qual apontou índices abaixo da linha base em todos os casos (A = 0.63; B = 0.56; C = 0.59), embora apresentando pequena melhoria pela integração, como foi possível determiná-lo, com a aplicação da Percentagem de Impacto da Tecnologia (PIT) que foi positiva no conjunto de estabelecimentos (PIT Médio: A = 57,28; B = 34; C = 13,64). Logo, é fundamental aprimorar a disposição de nutrientes nos solos de todas as propriedades, seguindo nessa prática as normas da produção orgânica, estipuladas na legislação brasileira. Adicionalmente foram ainda desenvolvidas entrevistas semiestruturadas com outros produtores da RIDE-DF, que do mesmo modo contemplam esse manejo integrado em suas propriedades. As entrevistas permitiram conhecer a percepção que têm aqueles produtores a respeito da atividade em análise, apontando que a criação animal é vista como uma prática complementar à produção vegetal, e que sua manutenção nas propriedades favorece essencialmente a obtenção de alimentos, ocupando áreas significativamente menores das propriedades. Ainda assim, os produtores reconheceram outras vantagens da criação de maneira integrada com as áreas de culturas, principalmente aquela relacionada com a obtenção de esterco. Porém a quantidade de animais apresenta-se insuficiente para o requerimento de nutrientes do solo, em todas as unidades, o que restringe seu nível de integração, ao ser necessário adquirir adubos desde fora das propriedades. The present study analyzed the environmental and socioeconomic impacts of the integrated production of ecological base, understood as the one that considers both the vegetal production and the animal husbandry in the same unit, and that propitiates in these two activities actions aimed at its long-term sustainability. To that end, three family farm units, named "A", "B" and "C", located in the Integrated Region of the Federal District and Surroundings (RIDE - DF) were evaluated according to the indicators of the System for Weighted Environmental Impact Assessment of New Rural Activities (APOIA-NovoRural) which includes 62 indicators integrated into five sustainability dimensions: (a) Landscape ecology; (b) Quality of environmental compartments (atmosphere, water and soil); (c) Sociocultural values; (d) Economic values and (e) Management and Administration. It was confirmed that for the studied units the integrated ecological production resulted in positive impacts, since the sustainability index of the activity was above the baseline of environmental suitability, stipulated at 0.70 (on a scale of 0 to 1) for the three cases, as follows: A = 0.78; B = 0.75 and C = 0.78. The positive performance of the three units in the Management and Administration dimension (Indexes: A = 0.87, B = 0.90, C = 0.87) was supported by the strong dedication of those responsible for the activities of this integrated management, good institutional relationships and, especially, for the management and use of the resources of the production units. On the other hand, there were unsatisfactory performances for the environmental compartments dimension, especially soil characteristics, which indicated indices below the baseline in all cases (A = 0.63, B = 0.56, C = 0.59), although showing tendencies to improvement as defined by the percentage of technological impact (PIT) which was positive in the set of studied establishments (average PIT A = 57.28, B = 34, C = 13.64). Therefore, it is fundamental to improve the nutrient disposition in soils of all the establishments, following in this practice the norms of organic production, stipulated in the Brazilian legislation. In addition, semi-structured interviews were also carried out with other RIDE-DF farmers, who also contemplate this integrated management in their establishments. The interviews facilitated an understanding about the perceptions that these farmers have about the activity under analysis, pointing out that animal husbandry is seen as a complementary practice to vegetal production, and that its maintenance in the farms warrants mainly the obtaining of food that it provides to the family, while occupying minor areas. Nonetheless, farmers recognized other benefits of raising animals in an integrated manner with cropping areas especially that related to manuring. However, the quantity of animals is insufficient for the nutrient requirement of the soils in all the farm units, which restricts the level of integration, making it necessary to acquire fertilizers outside the properties.

EUROfusion Consortium 633053

A theoretical model for isotopologues of beryllium monohydride, BeH, BeD and BeT, A ${}^{2}{\rm{\Pi }}$ to X ${}^{2}{{\rm{\Sigma }}}^{+}$ visible and X ${}^{2}{{\rm{\Sigma }}}^{+}$ to X ${}^{2}{{\rm{\Sigma }}}^{+}$ infrared rovibronic spectra is presented. The MARVEL procedure is used to compute empirical rovibronic energy levels for BeH, BeD and BeT, using experimental transition data for the X ${}^{2}{{\rm{\Sigma }}}^{+}$, A ${}^{2}{\rm{\Pi }}$, and C ${}^{2}{{\rm{\Sigma }}}^{+}$ states. The energy levels from these calculations are then used in the program Duo to produce a potential energy curve for the ground state, X ${}^{2}{\rm{\Sigma }}$, and to fit an improved potential energy curve for the first excited state, A ${}^{2}{\rm{\Pi }}$, including a spin–orbit coupling term, a Λ-doubling state to state (A–X states) coupling term, and Born–Oppenheimer breakdown terms for both curves. These, along with a previously computed ab initio dipole curve for the X and A states are used to generate vibrational-rotational wavefunctions, transition energies and A-values. From the transition energies and Einstein coefficients, accurate assigned synthetic spectra for BeH and its isotopologues are obtained at given rotational and vibrational temperatures. The BeH spectrum is compared with a high resolution hollow-cathode lamp spectrum and the BeD spectrum with high resolution spectra from JET giving effective vibrational and rotational temperatures. Full A–X and X–X line lists are given for BeH, BeD and BeT and provided as supplementary data on the ExoMol website.

Figure S2. Outline of the combined green/red image analysis for balanced mutants. Briefly, post well segmentation in the green channel, the worms are segmented after enhancing the contrast in the Brightfield channel (image 1). Acceptance criteria (Additional File 8) are applied to remove artefacts (blue accepted, yellow rejected). The worm mask is transferred to the green image to identify, if needed, worms with green heads based on the green head ID (image 2 and image 3). With the final worm mask dilated (image 5), the dilated region around the worm is used to calculate the immediate background intensity. Finally, the targets are linked together to get all three measurement regions (Dilated worms, Worm minus Green head and Final worm mask) together in one target (Fig. 4). As mentioned earlier, the software links targets, two at a time, and there must be at least one pixel overlap to achieve a linkage. (PDF 7627 kb)

The International Tokamak Physics Activity topical group on integrated operational scenarios has compiled a database of stationary H-mode discharges at q95 ~ 3 from AUG, C-Mod, DIII-D, JET and JT-60U, for both carbon wall and high-Z metal wall experiments with ~3300 entries. The analyses focus on discharges that are stationary for ⩾5 thermal energy confinement times to evaluate the baseline scenario proposed for ITER at 15 MA for achieving its goals of Q = 10, fusion power of 500 MW at normalised pressure, βN = 1.8 and normalised confinement as predicted by the standard H-mode scaling, H98y2 = 1. With the data restricted to stationary H-modes at q95 ~ 3, the database shows significant variation of thermal energy confinement compared to the standard H-mode scaling (IPB98(y,2)) in dimensionless form. The data show similar scaling with normalised gyro-radius, but more favourable scaling towards lower collision frequency and more favourable scaling with plasma beta. Using all the engineering variables employed in IPB98(y,2), results in an overfit due to correlations among the data. Moreover, there are significant residual trends in the confinement for plasma current, device size, loss power, and in particular for the plasma density. Significant differences between results obtained for devices with a carbon wall and high-Z metal wall are observed in the data, with data from carbon wall devices providing a larger operating space, encompassing ITER parameters or even exceeding them. H-modes in high-Z metal wall devices have, so-far, not accessed conditions at low collision frequencies, have lower normalised confinement (H98y2 ~ 0.8–0.9) at low input power or beta, achieving H98y2 ~ 1.0 only at input powers two times the L- to H-mode transition scaling predictions and at βN ~ 2.0. Hence, only the best H-modes with high-Z metal walls reach ITER baseline performance requirements. The data show that operating at high plasma density, with line-averaged density at 85% of Greenwald density is achievable for H98y2 > 0.95 for a range of plasma configurations, and that operation at low plasma inductance with li(3) ~ 0.7–0.75 is feasible. Scenario simulations employed for projecting the plasma performance in ITER should incorporate a lower thermal confinement at low plasma beta for the entry to burn and provide projections using higher levels of plasma core radiation by plasma impurities. Moreover, ITER projections should not subtract the core radiation in the evaluation of the thermal confinement time and H98y2, to allow a fair comparison with experimental data currently available. From the data presented here, it is likely that in ITER the energy confinement time will not increase with plasma density and will have no degradation with plasma beta. The analyses indicate that the data at q95 ~ 3 are consistent with achievement of the ITER mission goals at 15 MA. EURATOM 633053 U.S. Department of Energy DE-FC02-99ER54512

Figure S1. Effect of haf-1 deletion in the UPRmt. a. haf-1(ok705) deletion further induces Phsp-6::GFP expression upon depletion of the PHB complex (phb-1(RNAi) or phb-2(RNAi)). Bar graphs show quantification of Phsp-6::GFP. Day 1 adults are shown. b. haf-1(ok705) deletion also enhances the expression of the UPRmt reporter Phsp-6::GFP in phb-2(tm2998) deletion mutants. Day 5 adults were imaged. c. haf-1(ok705) deletion further induces Phsp-6::GFP expression upon RNAi depletion of the mitochondrial AAA protease (spg-7(RNAi)). Day 1 adults are shown. All bar graphs show quantification of Phsp-6::GFP (mean ± SD); P value shown in each panel; two-tailed unpaired t test; n = 20; two biological repeats, one representative experiment is shown. (PDF 3830 kb)

The issue of the most appropriate red blood cell transfusion policy has been addressed by a number of randomised controlled trials, conducted over the last decades, comparing the effects on patients’ outcome of restrictive blood transfusion strategies (transfusing when the haemoglobin concentration is less than 7 g/dL to 8 g/dL) vs more liberal ones (transfusing when the haemoglobin concentration is less than 9 g/dL to 10 g/dL) in a variety of clinical settings. In parallel, various systematic reviews and meta-analyses have tried to perform pooled analyses of the data from these randomised controlled trials and their results have been utilised by scientific societies to provide recommendations and guidelines on red blood cell transfusion thresholds. All these aspects will be critically discussed in this narrative review.

A fast-track anaemia clinic (FTAC) for the management of moderate-to-severe iron-deficiency anaemia (IDA) was established in our Emergency Department in 2010. In this FTAC, the replacement of packed red cell transfusion by ferric carboxymaltose administration was proven to be safe and effective. The aim of this study was a cost-analysis of IDA management in the FTAC, comparing this management with the previous standard care pathway consisting of packed red cell transfusion, if needed, and referral to outpatient specialised care.

[ESP] En la actualidad surgen una gran cantidad de innovaciones en el ámbito de la domótica. Cada fabricante quiere participar en uno de los nichos que ha evolucionado favorablemente, pero las soluciones sugeridas por estos no permiten la interacción entre ellas. Esto produce que vuelvan a aparecer algunos de los problemas que ya surgieron. Los sistemas de especificación cerrada limitan el número de productos que un usuario puede instalar en su hogar, ya que los nuevos dispositivos tienen que ser de la misma empresa. Esto puede ser un inconveniente para aquellas personas que decidan incorporar la domótica en su vivienda. Esta es la razón por la cual se ha desarrollado este trabajo. Se presenta una alternativa versátil, que se basa en una especificación abierta y se apoyada en estándares internacionales ampliamente extendidos. La creación de un nuevo protocolo de estas características podría permitir que algunos clientes se decanten por incorporar en sus hogares un sistema domótico. [ENG] Nowadays, a vast number of innovations appears within home automation market. Each manufacturer wants to participate in a market niche which has evolved favorably, but solutions suggested by enterprises do not allow interaction between them. This leads to the appearance of some old problems. Closed specification systems may decrease the number of products a user can install in their homes, as the new devices must be of the same brand. This may be a disadvantage for them who decided to incorporate domotics into their homes. That is the reason why this work has been developed. A versatile alternative has been presented, which relies on an open specification and it is based in widely extended international standards. The creation of this new protocol with this features would allow that some clients opt for incorporate in their homes one of these systems. [ESP] Escuela Técnica Superior de Ingeniería Industrial Universidad Politécnica de Cartagena

Memoria presentada como Trabajo Fin de carrera obteniendo la puntuación de Matricula de Honor 10.-- Tutores del Trabajo Fin de Grado: Undabeytia López, Tomás y Florido Fernández, M.C.