1. Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring
- Author
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Juliano de Paula Souza, Bruna Lais Santos de Jesus, André Luíz Giusti, Rosa Maria Mendes Viana, Ricardo de Souza Cardoso, Gláucia Maria Almeida, Marjorie Cornejo Pontelli, Beate Mareike Kümmerer, Danillo Lucas Alves Espósito, Danilo Machado de Melo, Thaís Melquíades de Lima, Suellen Gomes Salustiano, Ronaldo Bragança Martins, Ivan Savioli Ferraz, and Eurico Arruda more...
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Physiology (medical) ,Biochemistry (medical) ,Public Health, Environmental and Occupational Health ,General Medicine - Abstract
Vertical transmission of Chikungunya virus (CHIKV) has been reported in humans, but the transmission routes have not been completely understood, and experimental animal models are needed to enable detailed investigation of the transmission and pathogenesis of congenital infections. The intertwining of immune response and virus components at the gestation/breastfeeding interfaces between mother and fetus/newborn may have effects during the offspring development. An experimental model of CHIKV was established by infecting pregnant BALB/c female mice that enabled confirmation that dams inoculated up to the 10 more...
- Published
- 2023
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