Back to Search Start Over

Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring

Authors :
Juliano de Paula Souza
Bruna Lais Santos de Jesus
André Luíz Giusti
Rosa Maria Mendes Viana
Ricardo de Souza Cardoso
Gláucia Maria Almeida
Marjorie Cornejo Pontelli
Beate Mareike Kümmerer
Danillo Lucas Alves Espósito
Danilo Machado de Melo
Thaís Melquíades de Lima
Suellen Gomes Salustiano
Ronaldo Bragança Martins
Ivan Savioli Ferraz
Eurico Arruda
Source :
Translational Research. 255:109-118
Publication Year :
2023
Publisher :
Elsevier BV, 2023.

Abstract

Vertical transmission of Chikungunya virus (CHIKV) has been reported in humans, but the transmission routes have not been completely understood, and experimental animal models are needed to enable detailed investigation of the transmission and pathogenesis of congenital infections. The intertwining of immune response and virus components at the gestation/breastfeeding interfaces between mother and fetus/newborn may have effects during the offspring development. An experimental model of CHIKV was established by infecting pregnant BALB/c female mice that enabled confirmation that dams inoculated up to the 10

Details

ISSN :
19315244
Volume :
255
Database :
OpenAIRE
Journal :
Translational Research
Accession number :
edsair.doi.dedup.....698f706066c55b8527b0fc6f2a56ceb0
Full Text :
https://doi.org/10.1016/j.trsl.2022.12.001