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Project Baikal journal publishes the reports of RAACS academicians at the Jubilee General Meeting of members of the Russian Academy of Architecture and Construction Sciences, which was held from 11 to 13 October 2022 in the Central House of the Architect, Moscow.L. Lyakhovich, academician and head of the Siberian Regional Branch of the RAACS, outlined the history of the Academy in Russia since 1764 up to the present time and highlighted important aspects of the RAACS activities. He emphasized that the activities of its members have greatly determined the strategy for the development of living environment.

For some elastic systems with a finite number of degrees of freedom of masses, in which the direc-tions of mass movement are parallel and lie in the same plane (for example, rods), special methods have been developed for creating additional constraints, the introduction of each of which purposefully increases the value of only one natural frequency and does not change any from the natural modes. The method of forming a matrix of additional stiffness coefficients that characterize such targeted constraint in this problem can also be applied when solving a similar problem for elastic systems with a finite number of degrees of mass freedom, in which the directions of mass movement are parallel, but do not lie in the same plane (for example, plates). At the same time, for such systems, only the requirements for the design schemes of additional targeted constraints are formulated, and not the methods for their creation. The distinctive paper is devoted to solution of corresponding sample of plate analysis with the use of approach that allows researcher to create computational schemes for additional targeted constraints for such systems.

Supplementary Data from Constitutive Activation of Caspase-3 and Poly ADP Ribose Polymerase Cleavage in Fanconi Anemia Cells

We consider a class of theories with unfree gauge symmetry, whose gauge parameters are restricted by differential equations. We demonstrate that such theories admit global conserved quantities, whose on-shell values are defined by asymptotics of the fields rather than Cauchy data. The global conserved quantities can be deduced proceeding from the equations restricting gauge parameters, and they are treated differently by two BRST complexes corresponding to a system with unfree gauge symmetry., Comment: 6 pages, to appear in PEPAN Letters

For some elastic systems with a finite number of degrees of freedom of masses, in which the directions of mass movement are parallel and lie in the same plane (for example, rods), special methods have been developed for creating additional constraints, the introduction of each of which purposefully increases the value of only one natural frequency and does not change any from the natural modes. The method of forming a matrix of additional stiffness coefficients that characterize such targeted constraint in this problem can also be applied when solving a similar problem for elastic systems with a finite number of degrees of mass freedom, in which the directions of mass movement are parallel, but do not lie in the same plane (for example, plates). At the same time, for such systems, only the requirements for the design schemes of additional targeted constraints are formulated, and not the methods for their creation. The distinctive paper proposes an approach that allows researcher to create computational schemes for additional targeted constraints for such systems. A variant of the computational scheme, represented by a rod system with one degree of activity, is considered. Some special properties of such targeted constraints are revealed. When forming the computational scheme, the material consumption for creating a constraint is minimized, and design restrictions are taken into account. Particular attention is paid to the modification of the computational scheme of the constraint, when, during its formation, rods appear that “pass” through the original system.

Friedreichs Ataxia is an autosomal recessive genetic disease causing the defective gene product, frataxin. A body of literature has been focused on the attempts to counteract frataxin deficiency and the consequent iron imbalance, in order to mitigate the disease-associated prooxidant state and clinical course. The present mini review is aimed at evaluating the basic and clinical reports on the roles and the use of a set of iron chelators, antioxidants and some cofactors involved in the key mitochondrial functions. Extensive literature has focused on the protective roles of iron chelators, coenzyme Q10 and analogs, and vitamin E, altogether with varying outcomes in clinical studies. Other studies have suggested mitoprotective roles for other mitochondrial cofactors, involved in Krebs cycle, such as alpha-lipoic acid and carnitine, involved in acyl transport across the mitochondrial membrane. A body of evidence points to the strong antioxidant properties of these cofactors, and to their potential contribution in mitoprotective strategies in Friedreich's Ataxia clinical evolution. Thus, we suggest the rationale for planning combination strategies based on the three mitochondrial cofactors and of some antioxidants and iron binders as mitoprotective cocktails in FRDA patients, calling attention to clinical practitioners of the importance to implement clinical trials. Copyright © 2020. Published by Elsevier Inc.

Ca2+-regulated photoproteins of ctenophores lose bioluminescence activity when exposed to visible light. Little is known about the chemical nature of chromophore photoinactivation. Using a total synthesis strategy, we have established the structures of two unusual coelenterazine products, isolated from recombinant berovin of the ctenophore Beroe abyssicola, which are Z/E isomers. We propose that during light irradiation, these derivatives are formed from 2-hydroperoxycoelenterazine via the intermediate 8a-peroxide by a mechanism reminiscent of that previously described for the auto-oxidation of green-fluorescent-protein-like chromophores.

The field equations are proposed for the third rank tensor field with the hook Young diagram. The equations describe the irreducible spin two massless representation in any $$d\ge 3$$ d ≥ 3 . The starting point of the construction is the linearised system of Einstein equations which includes the Nordström equation. This equation, being considered irrespectively to the rest of the Einstein system, corresponds to the topological field theory. The general solution is a pure gauge, modulo topological modes which we neglect in this article. We find the sequence of the reducible gauge transformations for the linearised Nordström equation, with the hook tensor being the initial gauge symmetry parameter. By substituting the general solution of the Nordström equation into the rest of the Einstein’s system, we arrive at the field equations for the hook tensor. The degree of freedom number count confirms, it is the spin two theory.

A comparative study of the catalytic efficiency of Pd(0) and Cu(I) complexes in the reactions of adamantanamines with fluoro- and trifluoromethyl-substituted 2-bromopyridines was carried out using previously optimized catalytic systems. It was shown that in the absence of steric hindrances in the starting compounds, the copper and palladium catalysts were comparable in efficiency. In some cases, the yields of the target N-heteroarylated compounds in the copper-catalyzed reactions were even higher, which can be explained by the formation of N,N-diheteroarylated by-products under palladium-catalyzed conditions. At the same time, ortho-fluorine- and ortho-trifluoromethyl-substituted 2-bromopyridines successfully react exclusively under palladium catalysis.

Differences in the production of cytokines by tumor biopsy specimens were revealed depending on the pathological prognostic stages of The American Joint Committee on Cancer (AJCC) of invasive nonspecific breast carcinoma (INBC). The patients with a predominant absence of metastases in combination with a triple negative molecular subtype differ from the patients with other pathological prognostic stages in the cytokine-producing tumor resource of IL-18, IL-1β, IL-1Ra, TNF-α, GM-CSF, and MCP-1.

This work has investigated analysis results of management problems and solutions to the processes organization for creating competitive products and production services of an industrial enterprise which were presented in the scientific reports of the section "Economics and organization of mechanical engineering production" of the All-Russian conference of young scientists and specialists (with international participation) titled "The future of mechanical engineering in Russia", held from September 22 to 25, 2020 at the BMSTU, substantiated the development relevance of scientific research specialty "Organization of production". This specialty includes the development of scientific, methodological,and system-technical foundations for the design of organizational structures of enterprises and organization of production processes. It also includes development of methods and means of informatization and computerization of production processes, their documentary support at all stages; development of scientific, methodological and system-technical principles for increasing the efficiency of the functioning and quality of the organization of production systems; improving the quality and competitiveness of products, quality control systems and product certification; development and implementation of the production management principles, including the training of personnel and the effectiveness of labor organization forms; analysis and synthesis of organizational and technical solutions; development of methods and tools for planning and managing production processes and their results. This work has been addressed to specialists in the field of theory and practice of organization of production

The article aims to justify the measures for organizing the formation and provision of information from the accounting system for the risk management process in order to ensure the stability and sustainability of the development of higher education institutions. The goal has been realized on the basis of the application of the methods of observation, comparison, analysis, synthesis, generalization and economic-statistical method. The made analysis allowed to determine the risks of non-fulfilment of information needs regarding the functioning of higher education institutions for each study group (applicants, students, participants, parents of students/applicants, administration, employers, customers of research projects, teachers, government, society, governing bodies), which made it possible to offer an organizational approach to the information support of risk management of educational activities. This approach covers corrective management actions (in terms of accounting functions) on each of the defined processes of the risk management system (admission process for higher education, planning the educational process, organizing the educational process, staffing educational activities), executives, responsible entities and output data. Taking into account the provisions of regulatory documents, scientists' developments and practical experience in risk management has allowed to determine the stages of risk management in educational activities of a higher education institution (risk analysis, risk assessment, direct risk management, risk monitoring, risk management reporting) indicating the role of accounting personnel in each of them. It has been substantiated that the main advantages of the proposed approach to information management of risk management of educational activities of higher educational institutions are the simplicity of use (provided with properly devised documentation), the complexity of the approach (coverage of all quality management system processes), responsiveness to identified risks; accounting structure of higher education institutions. It is proved that the proposals will contribute to the improvement of the accounting display of actions to minimize the risks of educational activities of higher educational institutions, thereby ensuring the strengthening of their competitiveness on the market of educational services.

A growing body of evidence supports the notion that cancer resistance is driven by a small subset of cancer stem cells (CSC), responsible for tumor initiation, growth, and metastasis. Both CSC and chemoresistant cancer cells may share common qualities to activate a series of self-defense mechanisms against chemotherapeutic drugs. Here, we aimed to identify proteins in chemoresistant triple-negative breast cancer (TNBC) cells and corresponding CSC-like spheroid cells that may contribute to their resistance. We have identified several candidate proteins representing the subfamilies of DNA damage response (DDR) system, the ATP-binding cassette, and the 26S proteasome degradation machinery. We have also demonstrated that both cell types exhibit enhanced DDR when compared to corresponding parental counterparts, and identified RAD50 as one of the major contributors in the resistance phenotype. Finally, we have provided evidence that depleting or blocking RAD50 within the Mre11-Rad50-NBS1 (MRN) complex resensitizes CSC and chemoresistant TNBC cells to chemotherapeutic drugs.

The previous research described estimated closeness of optimum piecewise constant section width in I-rods with stability or first eigen-frequency limits to the predicted minimum material consumption with regard to strength requirements in continuous change in variable rod parameters. It is however known that in construction, rods are generally designed with piecewise constant change in the section parameters. Besides, in another work, the criterion was formulated for assessment of optimum solutions of piecewise constant sections of I-rods with stability or the first eigen-frequency limits, without considering the strength requirements. This paper focuses on a more general problem of estimated closeness of optimum piecewise constant section width in I-rods with stability or first eigen-frequency limits to the predicted minimum material consumption with regard to strength requirements.

The relationship between the content of supernatant cytokines and the immune histochemical (IHC) expression of epithelial-mesenchymal transition (EMT) markers was studied in biopsy samples of invasive breast carcinoma of no special type (IBC-NST) from patients with and without lymphatic spread of metastases (group II and group I, respectively). The concentrations of TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF, MCP-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, and IL-1Ra, as well as the immunohistochemical (IHC) expression of EMT markers cadherin-E (CDH1), β-1 integrin (CD29) and type II collagen (CII) were assayed. Results have shown that the patients of these groups statistically significantly differed by spontaneous production of IL-18 and G-CSF, and by the index of the polyclonal activator influence (IPAI) on G-CSF production. The study of relationships between supernatant cytokine production and the IHC expression by biopsy samples revealed correlations between the parameter of CII expression in the tumor tissue and the cytokine production by tumor biopsy specimens; these correlation links were typical for all IBC-NST patients, while correlation links (both direct and reverse ones) between CDH1, CD29, and cytokine production varied in groups of patients with and without lymphatic spread of metastases. The study revealed the features of the correlation links between the cytokine production by the tumor, its microenvironment and the IHC expression of EMT markers in IBC-NST patients with and without lymphatic spread of metastasis.

The criterion for the minimum material consumption of strips strengthening the I-rod with stability or first eigen-frequency limits is formulated in previous studies for the case of continuous change of the variable parameter. It is known that this solution allows evaluating a real design project not only by the criterion of its proximity to the minimum material consumption, but also by the reference point in the real design. In many cases, it is used to replace the continuous change in the variable size of the rod-strengthening piecewise constant sections. The boundaries of these sections are based on the minimum material consumption. The width of the strengthening strips is determined by the optimization methods. The paper proposes the criterion allowing to correctly assess the termination of the optimization processes.

There are known methods for optimizing the flange width of I-shaped cross-section rods with stability constraints or the constraints for the value of the first natural frequency. Corresponding objective function has the form of the volume of the flange material for the case when only the flange width varies and the cross-section height, wall thickness and flange thickness are specified. Special criterion for assessment of proximity of corresponding an optimal solution to the design of minimal material capacity was formulated for the considering problem. In this case, the resulting solution may not meet some other unaccounted constraints, for example, strength requirements. Modification of solution in order to meet previously unaccounted constraints does not allow researcher to consider such design as optimal. In the distinctive paper allowance for strength requirements, stability constraints or constraints for the value of the first natural frequency are proposed within considering problem of optimization. Special approach is formulated, which proposes to assess proximity to the design of minimum of material capacity obtained as a result of optimization. Increment of the objective function and criteria corresponding to constrains and restrictions are under consideration within computational process.

The purpose of this research is to represent the results of the development of the design algorithm for the logistics system for the distribution of products of a mechanical engineering enterprise, which would determine the characteristics of the production distribution channel, the optimal arrangement of the elements of the logistics system of product distribution in the environment, and also to optimize the resources flow with regard to the limitations. The main content of this research is the analysis of publications of Russian and foreign scientists and specialists in the field of production management, modeling and optimization of organizational structures and production processes, design of logistics systems. The practical significance of the research is the possibility of the appliance of the presented algorithm by the management team of a mechanical engineering enterprise in a market environment. It would permit to improve the efficiency of using the existing resources of the enterprise. This article is addressed to specialists in the field of theory and practice of production organization

Specific properties of optimum systems have been already considered in previous research. Moreover, the criteria were proposed for a correct assessment of proximity of optimum to minimum material consumption. In particular, the criteria are proposed for rods of rectangular crosssection with stability or first eigen-frequency limits. These criteria can be used for problem optimization, when the rod cross-sections continuously change longitudinally. The obtained optimum solutions can be considered as a perfect limited object. This optimum project function allows researcher to assess the real design solution using the proximity limit criterion (for example, material consumption limit). This kind of optimum design can also be used as a guideline for real design in terms of a stage-by-stage process of transition from a perfect to real object. In this case, it is possible to assess changes in the object optimality at each stage as compared to the initial and idealized solutions. In particular, one of the variants of the process includes replacing the rod with continuous longitudinally varying cross-sections by a rod with piecewise constant sections. The section boundaries can be based on a perfect object, and cross-sections can be determined by one of the optimization methods. This paper presents criteria, which ensure the reliable definition of the time of completion of the optimization process.

The results of a pathomorphological study of intestinal wall of pheasants with tuberculosis were discussed. The object of the study were intestines of pheasants (n=5) which died from generalized tuberculosis. The aim of the study was to describe and classify pathological changes in the intestinal wall of pheasants with tuberculosis. Materials and research methods. The work was carried out at the department of normal and pathological morphology of KhSZVA. Methods of postmortem autopsy of birds with partial evisceration, macroscopic analysis of the condition of the intestinal wall, pathological examination of its samples, microscopy according to Zichl-Neelsen for the detection of acid-resistant mycobacteria, PCR were used. Result of the research. We revealed tuberculous lesions with varying degrees of intensity and complexity in the intestinal wall of pheasants. Mycobacterium tuberculosis (stick-shaped red colored microorganisms) detected in smears-prints intestine walls altered fragments using Zichl-Neelsen bacterioscopy. Final diagnosis “Tuberculosis of birds” was established based on macroscopic data, histopathological studies of the intestinal wall, Zichl-Neelsen bacterioscopy, PCR results. Tuberculous granulomas of alternative type predominated in the intestinal wall of pheasants. Proliferative granulomas were rarely detected. The complex of post-tuberculous reparative processes and indicators due to them was classified. In the intestinal wall created alterative type of ulceri with perifocal fibrosis as a result of degradation of tuberculosis granulomas. Scarring of ulcerative areas, local edema, abscess-like wall formations, strictures, partial obstruction of intestines were detected. Mixed forms of tuberculous intestinal lesions: nodular-ulcerative, including, with scarring and stenosis; nodular, including drain, with extra- and intramural abscess-like formations were diagnosed in four pheasants. Nodular monoform of intestinal lesions was classified in one pheasant.

Hausa literature is one of the well-studied African literatures. This paper explores Hausa creative writing, focusing both on the figure of author, marubuci, and the changes the concept of ‘author’ has undergone, motivated by social perceptions and demands. Modern mass media call attention in different ways to writers and their creative writing. Therefore, interviews with authors may provide valuable information, that has before now remained unexplored by the researchers, as well as some unique insights into the world of Hausa creating writing. Interviews constitute a particular genre in media industry contributing social communication and discussion. They also serve as a reliable source for understanding writer’s self-perception, and the perception of creative writing and authorship in the context of social and literary change. This paper explores interviews with several prominent Hausa language authors; among them are Shu’aibu Makarfi, Bilkisu Funtuwa, Binta Salma Mohammed, Hafsatu Ahmad Abdulwaheed, Ismail Bala Garba, Rahma A. Majid, and Bashir Abubakar Umar. The study seeks to prove that the nature of interaction between a writer’s self-perception and social expectations/ social perceptions for both creative writing and marubuci is a significant factor, that defines the development of Hausa literary movement. Moreover, that the development of Hausa literature in Northern Nigeria has been determined mostly by the self-perception of the authors, who aimed to improve literary tradition, and thus introduced new experimental trends, attitudes and forms into the literature. The study concludes that the contribution of modern Northern Nigerian writers to shaping the future development of Nigerian literature will definitely grow.

The material of patients with invasive carcinoma of no special type (ICNT) and nonmalignant diseases (ND) of the mammary gland was studied. When comparing the concentrations of histidine-rich glycoprotein (HRG) and E-cadherin (CDH1), statistically significant differences between ICNT and ND by HRG in the supernatant of blood cells and its spontaneous production by biopsies and by CDH1 at its induced production, as well as by influence indices of polyclonal activators on the production of CDH1 were found. When comparing the expression of immunohistochemical markers, no statistically significant differences between ICNT and ND were obtained.

We studied the effect of the HLDF differentiation factor on production of cytokines by biopsy samples of nonmalignant breast diseases (ND) and invasive breast carcinoma of no special type (IBC-NST), in the absence and presence of lymphogenic metastasis: IBC-NST patients werw subdivided into groups on the prognostic protocol of the 8th edition of the AJCC committee. Group IA consisted of patients with T1-T2 tumor sizes, and predominantly with positive expression of estrogen and progesterone receptors (ER+/PR+/HER2-); it also included one patient with the HER2+ (ER-/PR-/HER2+) molecular subtype. The IB group was mainly composed of patients with T2 tumor size, with the presence of lymphogenic metastasis (in 8 out of 10) patients and with positive expression of estrogen and progesterone receptors (ER+/PR+/HER2-) and it also included three patients with the HER2+ (ER-/PR-/HER2+) molecular subtype. Group IIA consisted of patients with T1-T2 tumor sizes, mainly with no metastases in the lymph nodes (in 11 out of 12 patients) and with a triple negative molecular subtype. Group IIB included patients with T2 tumor size, the presence of nodal metastasis and the expression of markers of ER-/PR-/HER2 - and ER-/PR-/HER2+. Group IIIA consisted of patients with tumor size T1-T3, with the presence of nodal metastasis and the expression of markers of ER-/PR+/HER2+ and ER-/PR-/HER2+. Group IIIC consisted of patients with T3 tumor size, lymphogenic metastasis, and expression of ER-/PR-/HER2-markers (triple negative molecular subtype). Due to a limited number of patients in the groups IIB, IIIA and IIIC, as well as due to more severe clinical and pathological stages, according to the prognostic Protocol of the 8th edition of the AJCC Committee, they were pooled into group III. Concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, IL-1Ra, TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF and MCP-1 were assayed in supernatants of biopsy specimens of breast tissue. Results have shown that with IBC-NST, a statistically significantly higher level of spontaneous production (SP) by biopsy specimens of IL-17, IL-18, IFN-γ and VEGF, and a lower level of SP IL-6 as compared with ND. Patients of all clinical and pathological groups showed a high VEGF spontaneous production as compared with ND, while statistically significant differences from patients with ND were not found in IL-17 spontaneous production in group IB patients, and IL-18 spontaneous production were absent in group IA. Only in patients with IA and IB, the IL-6 spontaneous production was lower as compared to ND, and the IL-8 spontaneous production was lower in the IA group. IFN-γ spontaneous production was higher in patients with IBC-NST group IIA as compared with ND. Under the influence of the HLDF differentiation factor, it was found that the parameters of IBC-NST patients were statistically significantly higher in the production of IL-1Ra, IL-17, IL-18 and VEGF, and statistically significantly lower in the production of IL-6 as compared to ND. HLDF had a higher impact on the content of IL-18 in IBC-NST patients than in ND. After HDLF sublimation IL-6 values were lower in patients of groups IA and IB, and HLDF-induced IL-17 production was higher only in patients of group IA. Statistically significant differences in the index of influence of HLDF (IVHLDF), representing ratio of the cytokine concentration in the supernatants of a biopsy specimen stimulated by HLDF to spontaneous cytokine production, were found between ND and IBC-NST in the case of on IFN-γ production, and also in the case of IL-4 production (between patients in the absence and presence of lymphogenic metastasis). IVHLDF for production of IL-6, IL-8 and TNF-α was lower in group IIA patients compared to group IA, and IVHLDF for production of GM-CSF and MCP-1 was lower in group IIA as compared to group III, in addition IVHLDF for MCP-1 products was lower in group IIA as compared to ND. The HLDF effect on the cytokine production by the tumor and its microenvironment was different in ND patients and IBC-NST patients. HDLF suppressed IFN-γ production in the pooled group of IBC-NST patients; HLDF mainly had a suppressive effect on the production of IL-6, IL-8, TNF-α, GM-CSF and MCP-1 in IBC-NST patients of group IIA.Issledovali vliianie faktora differentsirovki HLDF na produktsiiu tsitokinov bioptatami pri nezlokachestvennykh zabolevaniiakh molochnoĭ zhelezy (NZ) i pri invazivnoĭ kartsinome molochnoĭ zhelezy nespetsificheskogo tipa (IKNT), pri otsutstvii i nalichii limfogennogo metastazirovaniia, a takzhe u patsientov s IKNT, raspredelennykh po podtipam na osnove prognosticheskogo protokola 8 izdaniia komiteta AJCC. Gruppu IA sostavili patsienty s razmerami opukholi T1-T2 i preimushchestvenno s polozhitel'noĭ ékspressieĭ retseptorov éstrogena i progesterona (ER+/PR+/HER2-) i odin patsient s HER2+ (ER-/PR-/HER2+) molekuliarnym podtipom. V gruppu IB byli vkliucheny patsienty s razmerami opukholi T2, preimushchestvenno s nalichiem limfogennogo metastazirovaniia (8 iz 10) i s polozhitel'noĭ ékspressieĭ retseptorov éstrogena i progesterona (ER+/PR+/HER2-), a takzhe tri patsienta s molekuliarnym podtipom HER2+ (ER-/PR-/HER2+). Gruppu IIA sostavili patsienty s razmerami opukholi T1-T2, preimushchestvenno s otsutstviem metastazov v limfouzlakh (11 iz 12 bol'nykh) i s troĭnym negativnym molekuliarnym podtipom. Gruppu IIB sostavili patsienty s razmerami opukholi T2, nalichiem limfogennogo metastazirovaniia i ékspressieĭ markerov: ER-/PR-/HER2- i ER-/PR-/HER2+. Gruppu IIIA sostavili patsienty s razmerami opukholi T1-T3, nalichiem limfogennogo metastazirovaniia i ékspressieĭ markerov: ER-/PR+/HER2+ i ER-/PR-/HER2+. Gruppu IIIC sostavili patsienty s razmerami opukholi T3, s nalichiem limfogennogo metastazirovaniia i s ékspressieĭ markerov ER-/PR-/HER2- (troĭnoĭ negativnyĭ molekuliarnyĭ podtip). Vvidu malogo kolichestva patsientov v gruppakh IIB, IIIA i IIIC, a takzhe v sviazi s bolee tiazhelymi kliniko-patologicheskimi stadiiami soglasno prognosticheskomu protokolu 8 izdaniia komiteta AJCC oni byli ob"edineny v odnu gruppu III. Kontsentratsii IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IL- 1β, IL-1Ra TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF i MCP-1 opredeliali v supernatantakh bioptatov tkani molochnoĭ zhelezy. Issledovaniia pokazali, chto pri IKNT otmechalsia statisticheski znachimo bolee vysokiĭ uroven' spontannoĭ produktsii (SP) IL-17, IL-18, IFN-γ i VEGF i bolee nizkiĭ uroven' SP IL-6 po sravneniiu s NZ molochnoĭ zhelezy. U patsientov vsekh kliniko-patologicheskikh grupp IKNT otmechena vysokaia SP VEGF po sravneniiu s NZ, togda kak statisticheski znachimye razlichiia ot patsientov s NZ po SP IL-17 otsutstvovali u patsientov gruppy IB, a po SP IL-18 otsutstvovali u patsientov IA. Tol'ko u patsientov grupp IA i IB SP IL-6 byla nizhe po sravneniiu s NZ, a SP IL-8 byla nizhe u patsientov gruppy IA. SP IFN-γ byla vyshe u patsientov s IKNT gruppy IIA po sravneniiu s NZ. Pri vozdeĭstvii faktora differentsirovki HLDF ustanovleno, chto pokazateli patsientov s IKNT byli statisticheski znachimo bolee vysokimi po produktsii IL-1Ra, IL-17, IL-18 i VEGF i statisticheski znachimo bolee nizkimi po produktsii IL-6 po sravneniiu s NZ molochnoĭ zhelezy. Pri vozdeĭstvii HLDF na produktsiiu IL-18 ego soderzhanie okazalos' vyshe u patsientov vsekh kliniko-patologicheskikh grupp po sravneniiu s patsientami s NZ. Po sravneniiu s NZ tol'ko u patsientov grupp IA i IB pokazateli IL-6 pri vozdeĭstvii HLDF byli nizhe, a indutsirovannaia HLDF produktsiia IL-17 byla vyshe tol'ko u patsientov gruppy IA. Statisticheski znachimye razlichiia po indeksu vliianiia HLDF (IVHLDF), predstavliaiushchim soboĭ otnoshenie kontsentratsii tsitokinov v supernatante bioptata, pri vozdeĭstvii HLDF k spontannoĭ produktsii tsitokinov byli ustanovleny mezhdu NZ i IKNT po IVHLDF na produktsiiu IFN-γ, a takzhe po IVHLDF na produktsiiu IL-4 mezhdu patsientami pri otsutstvii i nalichii limfogennogo metastazirovaniia. IVHLDF na produktsiiu IL-6, IL-8 i TNF-α byl nizhe u patsientov gruppy IIA po sravneniiu s gruppoĭ IA, a IVHLDF na produktsiiu GM-CSF i MCP-1 byl nizhe u gruppy IIA po sravneniiu s pokazateliami gruppy III, krome togo, IVHLDF na produktsiiu MCP-1 byl nizhe u gruppy IIA po sravneniiu s NZ. Vliianie faktora differentsirovki HLDF na produktsiiu tsitokinov opukhol'iu i ee mikrookruzheniem razlichno dlia patsientov s NZ i IKNT. Faktor differentsirovki okazyval supressiruiushchee vliianie na produktsiiu IFN-γ u patsientov s IKNT i na produktsiiu IL-4 tol'ko u patsientov s limfogennym metastazirovaniem i na produktsiiu IL-6, IL-8, TNF-α, GM-CSF i MCP-1 u patsientov s IKNT gruppy IIA.

Breast cancer, in most cases, is a malignant neoplasm associated with infiltration of a tumor with the cells that form its microenvironment and produce various cytokines. The aim of the study was to evaluate the cytokine-producing function of tumor cells and their microenvironment in biopsy specimen of patients with invasive carcinoma of no special type and in patients with benign breast diseases. To assess the cytokine-producing activity of the tumor and its microenvironment, the index of polyclonal activators influence on cytokine production by biopsy specimens of patients with invasive carcinoma of no special type (group I) and in patients with benign breast tumors (group II) was calculated. Group II was further subdivided into group IIa, which included only patients with fibroadenoma, and group IIb, which included the patients with leaf-shaped fibroadenoma, fibroadenomatosis, fibrocystic mastopathy, intraductal papillomatosis, sclerosing adenosis and fibrocystic mastopathy with microcalcifications. The concentrations of IL-2, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, IL-1Ra, TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF, and MCP-1 were measured in tumor biopsy supernatants. When comparing groups I and II, higher indices of the polyclonal activators influence on the production of IL-17, IL-18 and TNF-α were observed in patients with benign diseases. Higher indices of the polyclonal activators influence on the production of IL-18, TNF-α, and IL-1β and the ratio of IL1β/IL1Ra were observed in patients with fibroadenoma as compared to those with invasive carcinoma of no special type. There were no significant differences in the indices of the polyclonal activators influence between groups I and IIb. This suggests the existence of changes in the mammary gland in patients of group IIb similar to those present in patients with invasive carcinoma of no special type. Higher indices of polyclonal activators influence on the production of IL-1β, as well as the ratio of IL1β/IL1Ra were observed in the patients of group IIa compared to the patients of group IIb. The results of the study identify the features of the cytokine-producing resource of tumor biopsy specimens in patients with invasive carcinoma of no special type and with benign breast tumors.Rak molochnoĭ zhelezy v bol'shinstve sluchaev iavliaetsia primerom zlokachestvennogo novoobrazovaniia, sviazannogo s infil'tratsieĭ opukholi kletkami, obrazuiushchimi mikrookruzhenie opukholi i produtsiruiushchimi razlichnye tsitokiny. Tsel'iu issledovaniia byla otsenka tsitokinprodutsiruiushcheĭ funktsii opukholevykh kletok i ikh mikrookruzheniia v bioptatakh opukholi patsientov s invazivnoĭ kartsinomoĭ nespetsificheskogo tipa (gruppa I) i u patsientov s nezlokachestvennymi zabolevaniiami molochnoĭ zhelezy (gruppa II). Bol'nye II gruppy byli razdeleny na gruppu IIa, v kotoruiu voshli patsienty tol'ko s fibroadenomoĭ, i gruppu IIb, v kotoruiu voshli ostal'nye patsienty s listovidnoĭ fibroadenomoĭ, fibroadenomatozom, fibrozno-kistoznoĭ mastopatieĭ, vnutriprotokovym papillomatozom, skleroziruiushchim adenozom i fibrozno-kistoznoĭ mastopatieĭ s mikrokal'tsinatami. Kontsentratsiiu IL-2, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, IL-1Ra, TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF i MCP-1 opredeliali v supernatante bioptatov opukholeĭ. Dlia otsenki tsitokinprodutsiruiushcheĭ aktivnosti bioptatov opukholi i ee mikrookruzheniia opredeliali indeks vliianiia poliklonal'nykh aktivatorov na produktsiiu tsitokinov. Pri sravnenii I i II grupp byli polucheny vysokie indeksy vliianiia poliklonal'nykh aktivatorov na produktsiiu IL-17, IL-18 i TNF-α u patsientov s nezlokachestvennymi zabolevaniiami. Bolee vysokie znacheniia indeksov vliianiia poliklonal'nykh aktivatorov na produktsiiu IL-18, TNF-α, i IL-1β i sootnosheniia IL1β/IL1Ra byli u patsientov s fibroadenomoĭ po sravneniiu s invazivnoĭ kartsinomoĭ nespetsificheskogo tipa. Statisticheski znachimykh razlichiĭ v gruppakh I i IIb po indeksam vliianiia poliklonal'nykh aktivatorov obnaruzheno ne bylo. Éto pozvoliaet predpolozhit' sushchestvovanie analogichnykh invazivnoĭ kartsinome nespetsificheskogo tipa izmeneniĭ v molochnoĭ zheleze u patsientov IIb gruppy. Pri sravnenii grupp IIa i IIb byli polucheny bolee vysokie znacheniia indeksa vliianiia poliklonal'nykh aktivatorov na produktsiiu IL-1β, a takzhe sootnosheniia IL1β/IL1Ra u patsientov s fibroadenomoĭ molochnoĭ zhelezy. Provedennoe issledovanie pozvolilo vyiavit' osobennosti tsitokinprodutsiruiushchego resursa bioptatov opukholeĭ u patsientov s invazivnoĭ kartsinomoĭ nespetsificheskogo tipa i s dobrokachestvennymi opukholiami molochnoĭ zhelezy.

The relationship between the content of supernatant cytokines and the expression of non-specific type of markers of epithelial-mesenchymal transition markers in the presence (group II) and the absence of lymphogenous metastasis (group I) were studied in biopsy specimens of mammary invasive breast carcinoma. The concentrations of TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF, MCP-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β and IL-1Ra, as well as the expression of immunohistochemical (IHC) markers of the epithelial-mesenchymal transition - cadherin-E (CDH1), β-1 integrin (CD29) and type II collagen (CII) were assayed. Results have shown that patients of these groups statistically significantly differed in spontaneous production of IL-18 and G-CSF, in terms of the index of the effect of the polyclonal activator on G-CSF production. There was a correlation between the parameter of CII expression in tumor tissue and the production of cytokines by tumor biopsy specimens; it was characteristic of all patients with invasive carcinoma of a non-specific type, and correlations, both direct and reverse between the expression indices of CDH1, CD29 and cytokine production varied depending on the presence or the absence of lymphogenous metastasis. The study revealed the features of the correlation between the production of cytokines by the tumor, its microenvironment and the expression of IHC markers of the epithelial-mesenchymal transition in patients with invasive non-specific breast carcinoma in the presence and absence of lymphogenous metastasis.Izuchena vzaimosviaz' mezhdu soderzhaniem tsitokinov supernatantov i ékspressieĭ v bioptatakh invazivnoĭ kartsinomy molochnoĭ zhelezy nespetsificheskogo tipa markerov épitelial'no-mezenkhimal'nogo perekhoda pri nalichii (II gruppa) i otsutstvii (I gruppa) limfogennogo metastazirovaniia. Opredeliali kontsentratsiiu TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF, MCP-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β i IL-1Ra, a takzhe ékspressiiu immuno-gistokhimicheskikh (IGKh) markerov épitelial'no-mezenkhimal'nogo perekhoda – kadgerina-E (CDH1), β-1-integrina (CD29) i kollagena II tipa (CII). Po rezul'tatam issledovaniia patsienty étikh grupp statisticheski znachimo otlichalis' po spontannoĭ produktsii IL-18 i G-CSF, po indeksu vliianiia poliklonal'nogo aktivatora na produktsiiu G-CSF. Pri izuchenii vzaimosviazi mezhdu produktsieĭ tsitokinov supernatantami i ékspressieĭ v nikh IGKh markerov ustanovleno, chto korreliatsionnye sviazi mezhdu pokazatelem ékspressii CII v tkani opukholi i produktsieĭ tsitokinov bioptatami opukholi kharakterny dlia vsekh patsientov s invazivnoĭ kartsinomoĭ nespetsificheskogo tipa, a korreliatsionnye sviazi, kak priamye, tak i obratnye mezhdu pokazateliami ékspressii CDH1, CD29 i produktsieĭ tsitokinov, razlichalis' v zavisimosti ot nalichiia ili otsutstviia limfogennogo metastazirovaniia. Provedennoe issledovanie pozvolilo vyiavit' osobennosti korreliatsionnykh sviazeĭ mezhdu produktsieĭ tsitokinov opukhol'iu, ee mikrookruzheniem i ékspressieĭ IGKh – markerov épitelial'no-mezenkhimal'nogo perekhoda u patsientov s invazivnoĭ kartsinomoĭ molochnoĭ zhelezy nespetsificheskogo tipa pri nalichii i otsutstvii limfogennogo metastazirovaniia.

We consider the class of spinning particle theories, whose quantization corresponds to the continuous helicity representation of the Poincare group. The classical trajectories of the particle are shown to lie on the parabolic cylinder with a lightlike axis irrespectively to any specifics of the model. The space-time position of the cylinder is determined by the values of momentum and total angular momentum. The value of helicity determines the focal distance of parabolic cylinder. Assuming that all the world lines lying on one and the same cylinder are connected by gauge transformations, we derive the geometrical equations of motion for the particle. The timelike world paths are shown to be solutions to a single relation involving the invariants of trajectory up to fourth order in derivatives. Geometrical equation of motion is non-Lagrangian, but it admits equivalent variational principle in the extended set of dynamical variables. The lightlike paths are also admissible on the cylinder, but they do not represent the classical trajectories of this spinning particle. The classical trajectories of massless particle (with zero helicity) are shown to lie on hyperplanes, whose space-time position depends on momentum and total angular momentum.

We work out the description of the gauge symmetry of unimodular gravity in the constrained Hamiltonian formalism. In particular, we demonstrate how the transversality conditions restricting the diffeomorphism parameters emerge from the algebra of the Hamiltonian constraints. The alternative form is long known as parametrizing the volume preserving diffeomorphisms by unrestricted two-forms instead of the transverse vector fields. This gauge symmetry is reducible. We work out the Hamiltonian description of this form of unimodular gravity (UG) gauge symmetry. Becchi-Rouet-Stora-Tyutin--Batalin-Fradkin-Vilkovisky (BFV-BRST) Hamiltonian formalism is constructed for both forms of the UG gauge symmetry. These two BRST complexes have a subtle inequivalence: Their BRST cohomology groups are not isomorphic. In particular, for the first complex, which is related to the restricted gauge parameters, the cosmological constant does not correspond to any nontrivial BRST cocycle, while for the alternative complex it does. In the wording of physics, this means $\Lambda$ is a fixed parameter defined by the field asymptotics rather than the physical observable from the standpoint of the first complex. The second formalism views $\Lambda$ as the observable with unrestricted initial data., Comment: 13 pages, minor corrections, referrence added, to appear in Phys. Rev. D

The field equations are proposed for the third rank tensor field with the hook Young diagram. The equations describe the irreducible spin two massless representation in any $d\geq 3$. The starting point of the construction is the linearised system of Einstein equations which includes the Nordström equation. This equation, being considered irrespectively to the rest of the Einstein system, corresponds to the topological field theory. The general solution is a pure gauge, modulo topological modes which we neglect in this article. We find the sequence of the reducible gauge transformations for the linearised Nordström equation, with the hook tensor being the initial gauge symmetry parameter. By substituting the general solution of the Nordström equation into the rest of the Einstein's system, we arrive at the field equations for the hook tensor. The degree of freedom number count confirms, it is the spin two theory., 19 pages; minor corrections, reference added, to appear in European Physical Journal C

Retinitis pigmentosa (RP) is a group of mitochondrial diseases characterized by progressive degeneration of rods and cones leading to retinal loss of light sensitivity and, consequently, to blindness. To date, no cure is available according to the clinical literature. As a disease associated with pigmentation-related, pro-oxidant state, and mitochondrial dysfunction, RP may be viewed at the crossroads of different pathogenetic pathways involved in adverse health outcomes, where mitochondria play a preeminent role. RP has been investigated in a number of experimental and clinical studies aimed at delaying retinal hyperpigmentation by means of a number of natural and synthetic antioxidants, as well as mitochondrial cofactors, also termed mitochondrial nutrients (MNs), such as alpha-lipoic acid, coenzyme Q10 and carnitine. One should consider that each MN plays distinct-and indispensable-roles in mitochondrial function. Thus, a logical choice would imply the administration of MN combinations, instead of individual MNs, as performed in previous studies, and with limited, if any, positive outcomes. A rational study design aimed at comparing the protective effects of MNs, separately or in combinations, and in association with other antioxidants, might foresee the utilization of animal RP models. The results should verify a comparative optimization in preventing or effectively contrasting retinal oxidative stress in mouse RP models and, in prospect, in human RP cases.

Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with the worst prognosis after chemo- or radiation therapy. This is mainly due to the development of cancer chemoresistance accompanied by tumor recurrence. In this work, we investigated a new mechanism of acquired chemoresistance of TNBC cells. We showed that extracellular vehicles (EVs) of chemoresistant TNBC cells can transfer mitochondria to sensitive cancer cells, thus increasing their chemoresistance. Such transfer, but with less efficiency, can be carried out over short distances using tunneling nanotubes. In addition, we showed that exosome fractions carrying mitochondria from resistant TNBC cells contribute to acquired chemoresistance by increasing mtDNA levels with mutations in the mtND4 gene responsible for tumorigenesis. Blocking mitochondrial transport by exosome inhibitors, including GW4869, reduced acquired TNBC chemoresistance. These results could lead to the identification of new molecular targets necessary for more effective treatment of this type of cancer.

The paper considers the influence of the substrate polarity on the preparation of samples from sols for examination by X-ray photoelectron spectroscopy and atomic force microscopy.

Fanconi anemia (FA) is a chromosomal instability disorder of bone marrow associated with aplastic anemia, congenital abnormalities and a high risk of malignancies. The identification of more than two dozen FA genes has revealed a plethora of interacting proteins that are mainly involved in repair of DNA interstrand crosslinks (ICLs). Other important findings associated with FA are inflammation, oxidative stress response, mitochondrial dysfunction and mitophagy. In this work, we performed quantitative proteomic and metabolomic analyses on defective FA cells and identified a number of metabolic abnormalities associated with cancer. In particular, an increased de novo purine biosynthesis, a high concentration of fumarate, and an accumulation of purinosomal clusters were found. This was in parallel with decreased OXPHOS and altered glycolysis. On the whole, our results indicate an association between the need for nitrogenous bases upon impaired DDR in FA cells with a subsequent increase in purine metabolism and a potential role in oncogenesis.

Background The mitochondrial cofactors α-lipoic acid (ALA), coenzyme Q10 (CoQ10) and carnitine (CARN) play distinct and complementary roles in mitochondrial functioning, along with strong antioxidant actions. Also termed mitochondrial nutrients (MNs), these cofactors have demonstrated specific protective actions in a number of chronic disorders, as assessed in a well-established body of literature. Methods Using PubMed, the authors searched for articles containing information on the utilization of MNs in inflammatory disorders as assessed from in vitro and animal studies, and in clinical trials, in terms of exerting anti-inflammatory actions. Results The retrieved literature provided evidence relating acute pathologic conditions, such as sepsis and pneumonia, with a number of redox endpoints of biological and clinical relevance. Among these findings, both ALA and CARN were effective in counteracting inflammation-associated redox biomarkers, while CoQ10 showed decreased levels in proinflammatory conditions. MN-associated antioxidant actions were applied in a number of acute disorders, mostly using one MN. The body of literature assessing the safety and the complementary roles of MNs taken together suggests an adjuvant role of MN combinations in counteracting oxidative stress in sepsis and other acute disorders, including COVID-19-associated pneumonia. Conclusions The present state of art in the use of individual MNs in acute disorders suggests planning adjuvant therapy trials utilizing MN combinations aimed at counteracting proinflammatory conditions, as in the case of pneumonia and the COVID-19 pandemic.

A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., alpha-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential-and distinct-roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

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Introduction Breast cancer is a heterogeneous disease that has multiple molecular and morphological subtypes. Nonetheless, the relation between various molecular subtypes and functional characteristics of a tumor in terms of cytokine secretion remains unknown. Methods We studied spontaneous and mitogen-induced cytokine secretion by invasive breast carcinoma of no special type (IBC NST; cultured tumors and cultured peripheral blood cells), depending on a molecular tumor subtype (where “mitogens” means “polyclonal activators” (PA): phytohemagglutinin p, phytohemagglutinin M, concanavalin A, and Escherichia coli lipopolysaccharide). Enzyme-linked immunosorbent assays were used to determine concentrations of IL-6, IL-8, IL-10, IL-17, IL-18, IL-1β, IL-1Ra, TNF-α, IFN-γ, G-CSF, GM-CSF, VEGF, and MCP-1 in culture supernatants of the tumors and peripheral blood cells. Results The luminal B HER2-positive molecular subtype of IBC NST was found to feature the highest spontaneous secretion of IL-6 and IL-8 and the highest mitogen-induced secretion of IL-6, IL-8, IL-1Ra, and TNF-α by tumors; the highest mitogen-induced secretion of IL-2, IL-6, IL-8, IL-1β, TNF-α, IFN-γ, and G-CSF by peripheral blood cells; and the highest cytokine-producing potential (the ratio of mitogen-induced to spontaneous secretion) of peripheral blood cells for the secretion of IL-6, IL-8, and IL-1Ra as compared to other molecular subtypes. The triple-negative subtype of IBC NST was characterized by the lowest cytokine-producing potential of tumors for the secretion of IL-6 and IL-8 as compared to other molecular subtypes as well as a lower “stimulation index of polyclonal activators” (calculated as (cytokine secretion after incubation with PA)/(spontaneous cytokine secretion)) for IL-18 secretion as compared to luminal subtypes. The XYZ correlated with a suppressive effect of PA on cytokine secretion by tumors of the triple-negative molecular subtype. Conclusion Therefore, our findings indicate that in IBC NST of luminal B HER2-positive and triple-negative molecular subtypes, the cytokine network has distinctive functional features.

The study was carried out on samples of invasive breast carcinoma of no special type from 36 patients aged 48.0 to 62.8 years. The effect of HLDF on nonspecific invasive breast carcinoma was a decrease in the relative content of low-differentiated cells and an increase in the relative content of highly differentiated cells. HLDF did not have a cytotoxic effect leading to the death of low-differentiated cells but promoted promotes the acquisition of a higher degree of differentiation by them. A more pronounced effect of HLDF was observed in more aggressive metastasizing forms of neoplasia, which allows us to consider this differentiation factor as a candidate for use in the differentiation therapy of malignant neoplasms.

The article focuses on the influence of human leukemia differentiation factor (HLDF), carcinoembryonic antigen (CEA), and polyclonal activators (PA) on cytokine production by peripheral blood cells in breast cancer and benign breast diseases. It was found that the influence of internal factors on the production of cytokines by the peripheral blood cells is associated with lymphatic metastasis (CEA: IL-10; HLDF: IL-6, IL-1β, TNF-α, and G-CSF). One special circumstance was that there were no differences between the production of cytokines by peripheral blood cells in the patients with breast cancer compared to the patients with benign breast diseases with a high risk of malignant transformation. This is evidence of the functional similarity of peripheral blood cells in patients with these conditions. Cytokine production under the influence of PA was different only in case of TNF-α in all study groups.

The special properties of optimal systems have been already identified. Besides, criteria has been for­mulated to assess the proximity of optimal solutions to the minimal material consumption. In particular, the cri­teria were created for rods with rectangular and I-beam cross-section with stability constraints or constraints for the value of the first natural frequency. These criteria can be used for optimization when the cross sections of a bar change continuously along its length. The resulting optimal solutions can be considered as an idealized ob­ject in the sense of the limit. This function of optimal design allows researcher to assess the actual design solu­tion by the criterion of its proximity to the corresponding limit (for example, regarding material consumption). Such optimal project can also be used as a reference point in real design, for example, implementing a step-by­step process of moving away from the ideal object to the real one. At each stage, it is possible to assess the changes in the optimality index of the object in comparison with both the initial and the idealized solution. One of the variants of such a process is replacing the continuous change in the size of the cross sections of the rod along its length with piecewise constant sections. Boundaries of corresponding intervals can be selected based on an ideal feature, and cross-section dimensions can be determined by one of the optimization methods. The dis­tinctive paper is devoted to criteria that allow researcher providing reliable assessment of the endpoint of the op­timization process.

The catalytic efficiencies of palladium(0) and copper(I) complexes in the amination of 2-bromopyridine and its fluorine-containing derivatives with (1-adamantyl)methanamine and 2-(1-adamantyloxy)ethanamine were compared. Both types of catalytic systems were shown to be applicable for the preparation of the corresponding N-pyridyl derivatives from 3- and 5-fluoro- and 4-, 5-, and 6-trifluoromethyl-2-bromopyridines. DavePhos was found to be the most efficient ligand in the Pd(0)-catalyzed reactions; however, the reactions with 2-bromo-4-(trifluoromethyl)pyridine and 2-bromo-5-(trifluoromethyl)pyridine were accompanied by formation of a considerable amount of the diarylation product. The diarylation process was significantly suppressed in the presence of copper(I) complexes.

We consider constrained multi-Hamiltonian formulation for the extended Chern-Simons theory with higher derivatives of arbitrary finite order. The order $n$ extension of the theory admits $(n-1)$-parametric series of conserved tensors. The $00$-component of any representative of the series can be chosen as Hamiltonian. The theory admits a series of Hamiltonian formulations, including the canonical Ostrogradski formulation. The Hamiltonian formulations with different Hamiltonians are not connected by canonical transformations. Also, we demonstrate the inclusion of stable interactions with charged scalar field that preserves one specified Hamiltonian from the series., 10 pages, to appear in Russian Physics Journal