155 results on '"Lu, Guang"'
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2. Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review
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Chun‐wei Li, Kang Yu, Ng Shyh‐Chang, Zongmin Jiang, Taoyan Liu, Shilin Ma, Lanfang Luo, Lu Guang, Kun Liang, Wenwu Ma, Hefan Miao, Wenhua Cao, Ruirui Liu, Ling‐juan Jiang, Song‐lin Yu, Chao Li, Hui‐jun Liu, Long‐yu Xu, Rong‐ji Liu, Xin‐yuan Zhang, and Gao‐shan Liu
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Aged, 80 and over ,Aging ,Sarcopenia ,Adipose Tissue ,Physiology (medical) ,Humans ,Orthopedics and Sports Medicine ,Obesity ,Muscle, Skeletal ,Aged - Abstract
Age-associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing, adipose inflammation leads to the redistribution of fat to the intra-abdominal area (visceral fat) and fatty infiltrations in skeletal muscles, resulting in decreased overall strength and functionality. Lipids and their derivatives accumulate both within and between muscle cells, inducing mitochondrial dysfunction, disturbing β-oxidation of fatty acids, and enhancing reactive oxygen species (ROS) production, leading to lipotoxicity and insulin resistance, as well as enhanced secretion of some pro-inflammatory cytokines. In turn, these muscle-secreted cytokines may exacerbate adipose tissue atrophy, support chronic low-grade inflammation, and establish a vicious cycle of local hyperlipidaemia, insulin resistance, and inflammation that spreads systemically, thus promoting the development of sarcopenic obesity (SO). We call this the metabaging cycle. Patients with SO show an increased risk of systemic insulin resistance, systemic inflammation, associated chronic diseases, and the subsequent progression to full-blown sarcopenia and even cachexia. Meanwhile in many cardiometabolic diseases, the ostensibly protective effect of obesity in extremely elderly subjects, also known as the 'obesity paradox', could possibly be explained by our theory that many elderly subjects with normal body mass index might actually harbour SO to various degrees, before it progresses to full-blown severe sarcopenia. Our review outlines current knowledge concerning the possible chain of causation between sarcopenia and obesity, proposes a solution to the obesity paradox, and the role of fat mass in ageing.
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- 2022
3. The promotion effect of uniaxial strain on hydrogen aggregation in tungsten
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Ma, Fang-Fei, Li, Yu-Hao, Ren, Qing-Yuan, Zhou, Hong-Bo, and Lu, Guang-Hong
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Materials Science (miscellaneous) - Abstract
The aggregation behavior of hydrogen (H) isotopes after low-energy plasma irradiation is particularly important for tungsten (W) in future fusion devices. Here, using the first-principles calculation, we demonstrated an interesting strain effect that may drive the planar aggregation of interstitial H atoms in W. Although there are attractive interactions between H atoms, the spontaneous nucleation of these platelet-like H clusters in strain-free W appears impossible even at high H concentrations (up to 0.1 at.%) because of the extremely low configurational entropy. However, applied uniaxial strain significantly increased the binding energy of H platelets and enabled planar H clusters to form. These results suggest that uniaxial strain enhances the nucleation and growth of H platelets in W, regardless of whether it is a compressive or tensile strain. Moreover, the binding energy of one-layer H clusters was lower than that of parallel H platelets, implying that the formation of multi-layer H clusters in W and their stability is also promoted by uniaxial strain. Meanwhile, the presence of planar H clusters dramatically reduced the vacancy formation energy in W, which in turn provided an extra trapping site to accommodate excessive H atoms. These results provide an important reference for understanding the H evolution in W-PFMs.
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- 2023
4. sj-docx-1-tpp-10.1177_20451253231175302 – Supplemental material for Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder
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Chen, Hui Juan, Ke, Jun, Qiu, Jie, Xu, Qiang, Zhong, Yuan, Lu, Guang Ming, Wu, Yanglei, Qi, Rongfeng, and Chen, Feng
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FOS: Clinical medicine ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - Abstract
Supplemental material, sj-docx-1-tpp-10.1177_20451253231175302 for Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder by Hui Juan Chen, Jun Ke, Jie Qiu, Qiang Xu, Yuan Zhong, Guang Ming Lu, Yanglei Wu, Rongfeng Qi and Feng Chen in Therapeutic Advances in Psychopharmacology
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- 2023
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5. sj-docx-1-tpp-10.1177_20451253231175302 – Supplemental material for Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder
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Chen, Hui Juan, Ke, Jun, Qiu, Jie, Xu, Qiang, Zhong, Yuan, Lu, Guang Ming, Wu, Yanglei, Qi, Rongfeng, and Chen, Feng
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FOS: Clinical medicine ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified - Abstract
Supplemental material, sj-docx-1-tpp-10.1177_20451253231175302 for Altered whole-brain resting-state functional connectivity and brain network topology in typhoon-related post-traumatic stress disorder by Hui Juan Chen, Jun Ke, Jie Qiu, Qiang Xu, Yuan Zhong, Guang Ming Lu, Yanglei Wu, Rongfeng Qi and Feng Chen in Therapeutic Advances in Psychopharmacology
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- 2023
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6. Hybrid Long Document Summarization using C2F-FAR and ChatGPT: A Practical Study
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Lu, Guang, Larcher, Sylvia B., and Tran, Tu
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FOS: Computer and information sciences ,Computer Science - Computation and Language ,Computation and Language (cs.CL) - Abstract
Text summarization is a downstream natural language processing (NLP) task that challenges the understanding and generation capabilities of language models. Considerable progress has been made in automatically summarizing short texts, such as news articles, often leading to satisfactory results. However, summarizing long documents remains a major challenge. This is due to the complex contextual information in the text and the lack of open-source benchmarking datasets and evaluation frameworks that can be used to develop and test model performance. In this work, we use ChatGPT, the latest breakthrough in the field of large language models (LLMs), together with the extractive summarization model C2F-FAR (Coarse-to-Fine Facet-Aware Ranking) to propose a hybrid extraction and summarization pipeline for long documents such as business articles and books. We work with the world-renowned company getAbstract AG and leverage their expertise and experience in professional book summarization. A practical study has shown that machine-generated summaries can perform at least as well as human-written summaries when evaluated using current automated evaluation metrics. However, a closer examination of the texts generated by ChatGPT through human evaluations has shown that there are still critical issues in terms of text coherence, faithfulness, and style. Overall, our results show that the use of ChatGPT is a very promising but not yet mature approach for summarizing long documents and can at best serve as an inspiration for human editors. We anticipate that our work will inform NLP researchers about the extent to which ChatGPT's capabilities for summarizing long documents overlap with practitioners' needs. Further work is needed to test the proposed hybrid summarization pipeline, in particular involving GPT-4, and to propose a new evaluation framework tailored to the task of summarizing long documents.
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- 2023
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7. [Clinical observation of chiropractic manipulation in the treatment of degenerative scoliosis]
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Lu-Guang, Li, Jing-Hua, Gao, Chun-Yu, Gao, Wu, Sun, Jie, Luo, Ke-Xin, Yang, Jie, Yu, Jian-Guo, Li, Bao-Jian, Wang, Wei, Yang, and Ming-Hui, Zhuang
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Lumbar Vertebrae ,Spinal Fusion ,Treatment Outcome ,Scoliosis ,Manipulation, Chiropractic ,Lordosis ,Humans ,Retrospective Studies - Abstract
To observe clinical efficacy of chiropractic manipulation in the treatment of degenerative scoliosis (DS).From June 2017 to September 2019, 120 patients with degenerative scoliosis were randomly divided into treatment group (60 cases) and control group(60 cases). The patients in treatment group were treated with chiropractic manipulation once every other day for 4 weeks. The patients in control group were treated with eperisone hydrochloride tablets combined with thoracolumbar orthopedic(TSLO)brace, oral eperisone hydrochloride tablets 50 mg three times a day, wearing TSLO brace for not less than 8 hours a day. The course of treatment was 4 weeks. After the patients were selected into the group, visual analogue scale (VAS) and Oswestry Disability Index (ODI) were recorded before treatment, 1, 2, 3, 4 weeks after treatment and 1 month after treatment. The full length X-ray of the spine was taken before and 4 weeks after treatment, and the scoliosis Cobb angle, sagittal vertical axis (SVA) and lumbar lordosis (LL) were measured and compared. The adverse reactions during the treatment were recorded.There were significant differences in VAS and ODI between two groups at each time point after treatment (Chiropractic manipulation can effectively relieve pain and improve lumbar function in patients with degenerative scoliosis. The onset of action is faster than that oral eperisone hydrochloride tablets combined with TSLO brace, and it has better safety and can improve Cobb angle of patients with degenerative scoliosis.
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- 2022
8. Cover Image, Volume 139, Issue 26
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Zongmin Jiang, Liping Zhang, Ziyue Yao, Wenhua Cao, Shilin Ma, Yu Chen, Lu Guang, Zipeng Zheng, Chunwei Li, Kang Yu, and Ng Shyh‐Chang
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Cell Biology ,General Medicine - Published
- 2022
9. Improved genetic algorithm-based research on optimization of least square support vector machines: an application of load forecasting
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Zhang Xin-Yang, Li Hui, Lu Guang-Qian, Zhang Mei, and Lin Bao-De
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0209 industrial biotechnology ,Mathematical optimization ,Computer science ,Generalization ,Load forecasting ,Value (computer science) ,Computational intelligence ,Sample (statistics) ,02 engineering and technology ,Theoretical Computer Science ,Support vector machine ,020901 industrial engineering & automation ,Genetic algorithm ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Geometry and Topology ,State (computer science) ,Software - Abstract
In this paper, the load forecasting model is established to increase the precision of meteorological impacts, temperature, short-term power load forecasting, working and holiday factors by considering the power load. Further, IGA-LS-SVM is proposed which is a short-term power load forecasting technique based on AI algorithm. And to increase the forecast accuracy and generalization capability of LS-SVM, we applied the adopted mutation probability and new coding technology to the parameter optimization of LS-SVM. The temperature, load, weather state, working and holiday days be taken as prediction model as input, and load value was predicted output. We selected the sample data from meteorological information and historical load of a city in Yunnan province. By results, the prediction verifies the good prediction effect when associated with existing BP algorithm and the proposed IGA- LS-SVM algorithm yields a value 0.8274 more significant than all others, which is appropriate for short-term power load prediction.
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- 2021
10. Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs
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Chao Chen, Hong Wu, Ming Li, Guo-Dong Wang, Yan-Hu Liu, Xiao Xiao, Xue Cao, Hui-Juan Li, Weipeng Liu, Ya-Ping Zhang, and Lu-Guang Cheng
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Whole genome sequencing ,Genetics ,Candidate gene ,education.field_of_study ,Multidisciplinary ,Population ,Genome-wide association study ,Biology ,010502 geochemistry & geophysics ,behavioral disciplines and activities ,01 natural sciences ,Genome ,PPP2R2B ,Phenotype ,mental disorders ,education ,Gene ,0105 earth and related environmental sciences - Abstract
Obsessive-compulsive disorder (OCD) represents a heterogeneous collection of diseases with diverse levels of phenotypic, genetic, and etiologic variability, making it difficult to identify the underlying genetic and biological mechanisms in humans. Domestic dogs exhibit several OCD-like behaviors. Using continuous circling as a representative phenotype for OCD, we screened two independent dog breeds, the Belgian Malinois and Kunming Dog and subsequently sequenced ten circling dogs and ten unaffected dogs for each breed. Using population differentiation analyses, we identified 11 candidate genes in the extreme tail of the differentiated regions between cases and controls. These genes overlap significantly with genes identified in a genome wide association study (GWAS) of human OCD, indicating strong convergence between humans and dogs. Through gene expressional analysis and functional exploration, we found that two candidate OCD risk genes, PPP2R2B and ADAMTSL3, affected the density and morphology of dendritic spines. Therefore, changes in dendritic spine may underlie some common biological and physiological pathways shared between humans and dogs. Our study revealed an unprecedented level of convergence in OCD shared between humans and dogs, and highlighted the importance of using domestic dogs as a model species for many human diseases including OCD.
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- 2021
11. Obstructed Nearest Neighbor Query Under Uncertainty in the Internet of Things Environment
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Li Chuan-Wen, Lu Guang, Zhang Yi, Zhang Tong, and Chen Kun-Lun
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General Computer Science ,Computer science ,Internet of Things ,0102 computer and information sciences ,02 engineering and technology ,computer.software_genre ,uncertain data ,01 natural sciences ,k-nearest neighbors algorithm ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,Pruning (decision trees) ,Spatial analysis ,Nearest neighbor ,business.industry ,General Engineering ,010201 computation theory & mathematics ,Scalability ,Location-based service ,Trajectory ,Probability distribution ,The Internet ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,Data mining ,business ,lcsh:TK1-9971 ,computer ,obstructed space - Abstract
The internet of things provides a convenient life for all of us. Physical devices with locational systems connected to the internet can provide navigation and recommendation services in cooperation with the Location Based Services (LBS). The nearest neighbor query is the most common query type in the LBS research area. On the other hand, due to privacy protection or inaccuracies in measurement instructions, data uncertainties are typical in the IoT environment. This uncertainty will affect the results of nearest neighbor queries. The existence of plane obstacles also brings the challenge to the spatial data query. In this paper, the obstacles and data uncertainties in continuous nearest query are studied. We also designed a pruning strategy that significantly reduced the number of objects to be calculated. In addition, we propose a concept of safe region and an algorithm to generate a safe region. We also designed an index method for saving safe regions. The experimental results show that our approach outperforms the state-of-the-art one in efficiency and scalability.
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- 2021
12. Machine learning-based phenotypic screening for postmitotic growth inducers uncover vitamin D3 metabolites as small molecule ribosome agonists
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Zongmin Jiang, Liping Zhang, Ziyue Yao, Wenhua Cao, Shilin Ma, Yu Chen, Lu Guang, Zipeng Zheng, Chunwei Li, Kang Yu, and Ng Shyh‐Chang
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Machine Learning ,Calcitriol ,Cell Biology ,General Medicine ,Ribosomes ,Cell Proliferation ,Cholecalciferol - Abstract
To restore tissue growth without increasing the risk for cancer during aging, there is a need to identify small molecule drugs that can increase cell growth without increasing cell proliferation. While there have been numerous high-throughput drug screens for cell proliferation, there have been few screens for post-mitotic anabolic growth.A machine learning (ML)-based phenotypic screening strategy was used to discover metabolites that boost muscle growth. Western blot, qRT-PCR and immunofluorescence staining were used to evaluate myotube hypertrophy/maturation or protein synthesis. Mass spectrometry (MS)-based thermal proteome profiling-temperature range (TPP-TR) technology was used to identify the protein targets that bind the metabolites. Ribo-MEGA size exclusion chromatography (SEC) analysis was used to verify whether the ribosome proteins bound to calcitriol.We discovered both the inactive cholecalciferol and the bioactive calcitriol are amongst the top hits that boost post-mitotic growth. A large number of ribosomal proteins' melting curves were affected by calcitriol treatment, suggesting that calcitriol binds to the ribosome complex directly. Purified ribosomes directly bound to pure calcitriol. Moreover, we found that calcitriol could increase myosin heavy chain (MHC) protein translation and overall nascent protein synthesis in a cycloheximide-sensitive manner, indicating that calcitriol can directly bind and enhance ribosomal activity to boost muscle growth.Through the combined strategy of ML-based phenotypic screening and MS-based omics, we have fortuitously discovered a new class of metabolite small molecules that can directly activate ribosomes to promote post-mitotic growth.
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- 2022
13. Lin28a rejuvenates muscle stem cells via mitochondrial optimization
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Chunwei Li, Kang Yu, Wenhua Cao, Yan-Jiang Benjamin Chua, Min-Wen Jason Chua, Peng Wang, Bin Tean Teh, Jiali Su, Lanfang Luo, Yu Chen, Shilin Ma, Ruirui Liu, Lan Jiang, Zongming Jiang, Shuqing Liu, Xupeng Liu, Ng Shyh-Chang, Yuefan Wang, Taoyan Liu, Liping Zhang, Lu Guang, Yun Li, Luyao Guo, Wenwu Ma, Ziyue Yao, Na Ai, Ruiqi Rachel Wang, Tan J, Hefan Miao, and Kun Liang
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Somatic cell ,PAX3 ,Myocyte ,Stem cell factor ,Biology ,Stem cell ,Reprogramming ,Embryonic stem cell ,Tissue homeostasis ,Cell biology - Abstract
The well-conserved correlation between juvenility and tissue regeneration was first discussed by Charles Darwin. Ectopic Lin28 is known to play an important role in somatic reprogramming and tissue regeneration, but endogenous Lin28’s role in tissue homeostasis and juvenility had remained unclear. Through lineage tracing, we found that a rare subset of muscle stem cells (MuSCs) expressing Lin28a can respond to acute injury by proliferating as Pax3+ or Pax7+ MuSCs, and contribute to all types of myofibers during muscle regeneration. Compared with conventional Pax7+ MuSCs, Lin28a+ MuSCs express more Pax3 and show enhanced myogenicity in vitro. In terms of the epigenetic clock, adult Lin28a+ MuSCs lie between adult Pax7+ MuSCs and embryonic Pax7+ myoblasts according to their DNA methylation profiles. We found that Lin28a+ MuSCs upregulate several embryonic limb bud mesoderm transcription factors and could maintain a juvenile state with enhanced stem cell self-renewal and stress-responsiveness in vitro and in vivo. When combined with telomerase and TP53 inhibition to biomimic mouse Lin28a+ MuSCs, we found that Lin28a can rejuvenate and dedifferentiate aged human primary myoblasts into engraftable, self-renewing MuSCs. Mechanistic studies revealed that Lin28a activated the HIF1A pathway by optimizing mitochondrial ROS (mtROS), thereby rejuvenating MuSC self-renewal and muscle regeneration. Our findings connect the stem cell factor Lin28, mtROS metabolism and stress response pathways to the process of stem cell rejuvenation and tissue regeneration.
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- 2021
14. Summary of Research on Digital Pulse Collection and Analysis Technology
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Zhang Qiu-yue, Guo Ting-hang, Lu Guang-da, Han Yu, and Qie Tong-tong
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Signal processing ,Pulse (signal processing) ,Computer science ,business.industry ,Information technology ,Objectification ,business ,Data science ,Pulse diagnosis ,Analysis method - Abstract
Pulse diagnosis is an important part of traditional Chinese medicine’s four examinations: looking, smelling, asking, and cutting. The pulse signal can reflect the health of the human body’s internal haslets. With the development of information technology, the emergence of various pulse collection equipment and analysis algorithms provides a broad platform for the development of digital Chinese medicine. This article summarizes the currently commonly used pulse collection and analysis techniques, and analyzes the advantages and disadvantages of various collection and analysis methods, and finally proposes the improvement direction for the current research status, which provides a reference for the objectification of TCM diagnosis.
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- 2021
15. Overview of finger rehabilitation robots research
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Guo Ting-hang, Han Yu, Lu Guang-da, Qie Tong-tong, and Zhang Qiu-yue
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body regions ,surgical procedures, operative ,Hand function ,Rehabilitation ,Human–computer interaction ,medicine.medical_treatment ,technology, industry, and agriculture ,medicine ,Rehabilitation robot ,Rehabilitation robotics ,human activities - Abstract
With the advent of the aging population, post-stroke will cause hand function obstacles that affect fine manipulation of fingers. This article classifies finger rehabilitation robots and analyzes the mechanical structure, driving methods, and rehabilitation principles of Unger rehabilitation robots. The advantages and disadvantages of the development of finger rehabilitation robots are summarized.
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- 2021
16. SPURIOUS & INTENTIONAL HERDING BEHAVIOR IN PAKISTAN STOCK EXCHANGE
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Zhang Lu-guang, Zhu Zhaohui, and Fayyaz Ali
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Stock exchange ,Economics ,Monetary economics ,Spurious relationship ,Herd behavior - Published
- 2019
17. Percutaneous Endoscopic C2-C3 Medial Branches Neurotomy for Cervicogenic Headache
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Zhu Hongwei, Ni Bing, Lu Guang, Shu Wei, and Du Tao
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medicine.medical_specialty ,Percutaneous ,Cervical Disorder ,Spinal cord stimulation ,Neurosurgical Procedures ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Cervicogenic headache ,medicine ,Humans ,Local anesthesia ,Head and neck ,Aged ,business.industry ,Endoscopy ,Neurotomy ,medicine.disease ,Surgery ,Treatment Outcome ,030220 oncology & carcinogenesis ,Cervical Vertebrae ,Post-Traumatic Headache ,Female ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background Cervicogenic headache (CEH) is characterized by unilateral posterior head and neck pain originating from cervical structures and may be improved or resolved by successful treatment of the causative cervical disorder or lesion. Cervical medial branch radiofrequency (RF) lesion therapy is effective in some CEH patients with no significant pathologic abnormalities that can be surgically corrected. However, patients with refractory CEH are often encountered clinically. Case Description Here we describe the case of a 68-year-old female with an 18-year history of CEH who did not respond to a series of treatments including nonsteroidal antiinflammatory drugs, anticonvulsants, medial branch diagnostic block, medial branch RF lesion, and spinal cord stimulation. After careful examination, we performed percutaneous endoscopic right C2-C3 medial branch neurotomy under local anesthesia and neuroleptanalgesia. The patient's constant pain was ultimately relieved. Conclusions For patients with refractory CEH who failed medial branch RF lesion, which could be relieved briefly by diagnostic medial branch injection, percutaneous endoscopic C2-C3 medial branches neurotomy may alleviate their pain under the premise of full informed consent, accurate localization, careful intraoperative exploration, and stimulation testing.
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- 2019
18. A microcapsule oil dispersion for the controlled release of 1-methylcyclopropene in an open environment
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Pang Sen, Yong Xu, Xuemin Wu, Guo Xinyu, Jia Zhang, Zhenhua Zhang, Rui Zhao, Luoyun Chen, Lu-Guang Yang, and Ying-Jie Du
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inorganic chemicals ,Plant growth ,Materials science ,General Chemical Engineering ,Drop (liquid) ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,1-Methylcyclopropene ,complex mixtures ,01 natural sciences ,Controlled release ,0104 chemical sciences ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,0210 nano-technology - Abstract
1-Methylcyclopropene (1-MCP) is an important gaseous plant growth regulator. For its application as a gaseous pesticide, the plants with 1-MCP α-cyclodextrin microcapsule granules need to be enclosed in a sealed chamber. To provide a new spray formulation of 1-MCP for open environment application, herein, a novel 1-MCP microcapsule oil dispersion (1-MCP/MCOD) was prepared and characterized. It was found that 1-MCP could stay at higher concentrations for more than 36 hours during the controlled release experiment, and the SEM experiment showed good deposition of the 1-MCP/MCOD spray solution. In addition, the apple harvest application experiments showed that 1-MCP/MCOD could effectively prevent fruit drop at 3 μL L−1 in an open environment. These results not only supply a new 1-MCP/MCOD kind of formulation for the flexible application of the 1-MCP gas in an open environment, but also show that this microcapsule oil dispersion formulation has significant potential in gaseous pesticide applications.
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- 2019
19. Genome-wide association study reveals the genetic architecture of root hair length in maize
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Yan He, Li-Qun Chen, Jin-Hong Luo, Lin Liu, Aiai Xia, and Lu-Guang Jiang
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Genetics ,Candidate gene ,integumentary system ,Abiotic stress ,Research ,Single-nucleotide polymorphism ,Genome-wide association study ,Root hair ,Biology ,QH426-470 ,Phenotype ,Polymorphism, Single Nucleotide ,Zea mays ,Genetic architecture ,Maize ,GWAS ,Gene ,TP248.13-248.65 ,Biotechnology ,Disease Resistance ,Genome-Wide Association Study ,SNPs - Abstract
Background Root hair, a special type of tubular-shaped cell, outgrows from root epidermal cell and plays important roles in the acquisition of nutrients and water, as well as interactions with biotic and abiotic stress. Although many genes involved in root hair development have been identified, genetic basis of natural variation in root hair growth has never been explored. Results Here, we utilized a maize association panel including 281 inbred lines with tropical, subtropical, and temperate origins to decipher the phenotypic diversity and genetic basis of root hair length. We demonstrated significant associations of root hair length with many metabolic pathways and other agronomic traits. Combining root hair phenotypes with 1.25 million single nucleotide polymorphisms (SNPs) via genome-wide association study (GWAS) revealed several candidate genes implicated in cellular signaling, polar growth, disease resistance and various metabolic pathways. Conclusions These results illustrate the genetic basis of root hair length in maize, offering a list of candidate genes predictably contributing to root hair growth, which are invaluable resource for the future functional investigation.
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- 2021
20. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
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Klionsky, Daniel J, Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H, Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E, Adeli, Khosrow, Adolph, Timon E, Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B, Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N, Agrotis, Alexander, Aguilar, Patricia V, Ahmad, S Tariq, Ahmed, Zubair M, Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus, Akoumianaki, Tonia, Akpinar, Hafize Aysin, Al-Abd, Ahmed M, Al-Akra, Lina, Al-Gharaibeh, Abeer, Alaoui-Jamali, Moulay A, Alberti, Simon, Alcocer-Gómez, Elísabet, Alessandri, Cristiano, Ali, Muhammad, Alim Al-Bari, M Abdul, Aliwaini, Saeb, Alizadeh, Javad, Almacellas, Eugènia, Almasan, Alexandru, Alonso, Alicia, Alonso, Guillermo D, Altan-Bonnet, Nihal, Altieri, Dario C, Álvarez, Élida MC, Alves, Sara, Alves Da Costa, Cristine, Alzaharna, Mazen M, Amadio, Marialaura, Amantini, Consuelo, Amaral, Cristina, Ambrosio, Susanna, Amer, Amal O, Ammanathan, Veena, An, Zhenyi, Andersen, Stig U, Andrabi, Shaida A, Andrade-Silva, Magaiver, Andres, Allen M, Angelini, Sabrina, Ann, David, Anozie, Uche C, Ansari, Mohammad Y, Antas, Pedro, Antebi, Adam, Antón, Zuriñe, Anwar, Tahira, Apetoh, Lionel, Apostolova, Nadezda, Araki, Toshiyuki, Araki, Yasuhiro, Arasaki, Kohei, Araújo, Wagner L, Araya, Jun, Arden, Catherine, Arévalo, Maria-Angeles, Arguelles, Sandro, Arias, Esperanza, Arikkath, Jyothi, Arimoto, Hirokazu, Ariosa, Aileen R, Armstrong-James, Darius, Arnauné-Pelloquin, Laetitia, Aroca, Angeles, Arroyo, Daniela S, Arsov, Ivica, Artero, Rubén, Asaro, Dalia Maria Lucia, Aschner, Michael, Ashrafizadeh, Milad, Ashur-Fabian, Osnat, Atanasov, Atanas G, Au, Alicia K, Auberger, Patrick, Auner, Holger W, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Ávalos, Yenniffer, Aveic, Sanja, Aveleira, Célia Alexandra, Avin-Wittenberg, Tamar, Aydin, Yucel, Ayton, Scott, Ayyadevara, Srinivas, Azzopardi, Maria, Baba, Misuzu, Backer, Jonathan M, Backues, Steven K, Bae, Dong-Hun, Bae, Ok-Nam, Bae, Soo Han, Baehrecke, Eric H, Baek, Ahruem, Baek, Seung-Hoon, Baek, Sung Hee, Bagetta, Giacinto, Bagniewska-Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xiyuan, Bai, Yidong, Bairagi, Nandadulal, Baksi, Shounak, Balbi, Teresa, Baldari, Cosima T, Balduini, Walter, Ballabio, Andrea, Ballester, Maria, Balazadeh, Salma, Balzan, Rena, Bandopadhyay, Rina, Banerjee, Sreeparna, Banerjee, Sulagna, Bánréti, Ágnes, Bao, Yan, Baptista, Mauricio S, Baracca, Alessandra, Barbati, Cristiana, Bargiela, Ariadna, Barilà, Daniela, Barlow, Peter G, Barmada, Sami J, Barreiro, Esther, Barreto, George E, Bartek, Jiri, Bartel, Bonnie, Bartolome, Alberto, Barve, Gaurav R, Basagoudanavar, Suresh H, Bassham, Diane C, Bast, Robert C, Basu, Alakananda, Batoko, Henri, Batten, Isabella, Baulieu, Etienne E, Baumgarner, Bradley L, Bayry, Jagadeesh, Beale, Rupert, Beau, Isabelle, Beaumatin, Florian, Bechara, Luiz RG, Beck, George R, Beers, Michael F, Begun, Jakob, Behrends, Christian, Behrens, Georg MN, Bei, Roberto, Bejarano, Eloy, Bel, Shai, Behl, Christian, Belaid, Amine, Belgareh-Touzé, Naïma, Bellarosa, Cristina, Belleudi, Francesca, Belló Pérez, Melissa, Bello-Morales, Raquel, Beltran, Jackeline Soares De Oliveira, Beltran, Sebastián, Benbrook, Doris Mangiaracina, Bendorius, Mykolas, Benitez, Bruno A, Benito-Cuesta, Irene, Bensalem, Julien, Berchtold, Martin W, Berezowska, Sabina, Bergamaschi, Daniele, Bergami, Matteo, Bergmann, Andreas, Berliocchi, Laura, Berlioz-Torrent, Clarisse, Bernard, Amélie, Berthoux, Lionel, Besirli, Cagri G, Besteiro, Sebastien, Betin, Virginie M, Beyaert, Rudi, Bezbradica, Jelena S, Bhaskar, Kiran, Bhatia-Kissova, Ingrid, Bhattacharya, Resham, Bhattacharya, Sujoy, Bhattacharyya, Shalmoli, Bhuiyan, Md Shenuarin, Bhutia, Sujit Kumar, Bi, Lanrong, Bi, Xiaolin, Biden, Trevor J, Bijian, Krikor, Billes, Viktor A, Binart, Nadine, 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Antonia P, Sahay, Gaurav, Sahebkar, Amirhossein, Sahin, Mustafa, Sahin, Ozgur, Sahni, Sumit, Saito, Nayuta, Saito, Shigeru, Saito, Tsunenori, Sakai, Ryohei, Sakai, Yasuyoshi, Sakamaki, Jun-Ichi, Saksela, Kalle, Salazar, Gloria, Salazar-Degracia, Anna, Salekdeh, Ghasem H, Saluja, Ashok K, Sampaio-Marques, Belém, Sanchez, Maria Cecilia, Sanchez-Alcazar, Jose A, Sanchez-Vera, Victoria, Sancho-Shimizu, Vanessa, Sanderson, J Thomas, Sandri, Marco, Santaguida, Stefano, Santambrogio, Laura, Santana, Magda M, Santoni, Giorgio, Sanz, Alberto, Sanz, Pascual, Saran, Shweta, Sardiello, Marco, Sargeant, Timothy J, Sarin, Apurva, Sarkar, Chinmoy, Sarkar, Sovan, Sarrias, Maria-Rosa, Sarkar, Surajit, Sarmah, Dipanka Tanu, Sarparanta, Jaakko, Sathyanarayan, Aishwarya, Sathyanarayanan, Ranganayaki, Scaglione, K Matthew, Scatozza, Francesca, Schaefer, Liliana, Schafer, Zachary T, Schaible, Ulrich E, Schapira, Anthony HV, Scharl, Michael, Schatzl, Hermann M, Schein, Catherine H, Scheper, Wiep, Scheuring, David, Schiaffino, Maria Vittoria, Schiappacassi, Monica, Schindl, Rainer, Schlattner, Uwe, Schmidt, Oliver, Schmitt, Roland, Schmidt, Stephen D, Schmitz, Ingo, Schmukler, Eran, Schneider, Anja, Schneider, Bianca E, Schober, Romana, Schoijet, Alejandra C, Schott, Micah B, Schramm, Michael, Schröder, Bernd, Schuh, Kai, Schüller, Christoph, Schulze, Ryan J, Schürmanns, Lea, Schwamborn, Jens C, Schwarten, Melanie, Scialo, Filippo, Sciarretta, Sebastiano, Scott, Melanie J, Scotto, Kathleen W, Scovassi, A Ivana, Scrima, Andrea, Scrivo, Aurora, Sebastian, David, Sebti, Salwa, Sedej, Simon, Segatori, Laura, Segev, Nava, Seglen, Per O, Seiliez, Iban, Seki, Ekihiro, Selleck, Scott B, Sellke, Frank W, Selsby, Joshua T, Sendtner, Michael, Senturk, Serif, Seranova, Elena, Sergi, Consolato, Serra-Moreno, Ruth, Sesaki, Hiromi, Settembre, Carmine, Setty, Subba Rao Gangi, Sgarbi, Gianluca, Sha, Ou, Shacka, John J, Shah, Javeed A, Shang, Dantong, Shao, Changshun, Shao, Feng, Sharbati, Soroush, Sharkey, Lisa M, Sharma, Dipali, Sharma, Gaurav, Sharma, Kulbhushan, Sharma, Pawan, Sharma, Surendra, Shen, Han-Ming, Shen, Hongtao, Shen, Jiangang, Shen, Ming, Shen, Weili, Shen, Zheni, Sheng, Rui, Sheng, Zhi, Sheng, Zu-Hang, Shi, Jianjian, Shi, Xiaobing, Shi, Ying-Hong, Shiba-Fukushima, Kahori, Shieh, Jeng-Jer, Shimada, Yohta, Shimizu, Shigeomi, Shimozawa, Makoto, Shintani, Takahiro, Shoemaker, Christopher J, Shojaei, Shahla, Shoji, Ikuo, Shravage, Bhupendra V, Shridhar, Viji, Shu, Chih-Wen, Shu, Hong-Bing, Shui, Ke, Shukla, Arvind K, Shutt, Timothy E, Sica, Valentina, Siddiqui, Aleem, Sierra, Amanda, Sierra-Torre, Virginia, Signorelli, Santiago, Sil, Payel, Silva, Bruno J De Andrade, Silva, Johnatas D, Silva-Pavez, Eduardo, Silvente-Poirot, Sandrine, Simmonds, Rachel E, Simon, Anna Katharina, Simon, Hans-Uwe, Simons, Matias, Singh, Anurag, Singh, Lalit P, Singh, Rajat, Singh, Shivendra V, Singh, Shrawan K, Singh, Sudha B, Singh, Sunaina, Singh, Surinder Pal, Sinha, Debasish, Sinha, Rohit Anthony, Sinha, Sangita, Sirko, Agnieszka, Sirohi, Kapil, Sivridis, Efthimios L, Skendros, Panagiotis, Skirycz, Aleksandra, Slaninová, Iva, Smaili, Soraya S, Smertenko, Andrei, Smith, Matthew D, Soenen, Stefaan J, Sohn, Eun Jung, Sok, Sophia PM, Solaini, Giancarlo, Soldati, Thierry, Soleimanpour, Scott A, Soler, Rosa M, Solovchenko, Alexei, Somarelli, Jason A, Sonawane, Avinash, Song, Fuyong, Song, Hyun Kyu, Song, Ju-Xian, Song, Kunhua, Song, Zhiyin, Soria, Leandro R, Sorice, Maurizio, Soukas, Alexander A, Soukup, Sandra-Fausia, Sousa, Diana, Sousa, Nadia, Spagnuolo, Paul A, Spector, Stephen A, Srinivas Bharath, MM, St Clair, Daret, Stagni, Venturina, Staiano, Leopoldo, Stalnecker, Clint A, Stankov, Metodi V, Stathopulos, Peter B, Stefan, Katja, Stefan, Sven Marcel, Stefanis, Leonidas, Steffan, Joan S, Steinkasserer, Alexander, Stenmark, Harald, Sterneckert, Jared, Stevens, Craig, Stoka, Veronika, Storch, Stephan, Stork, Björn, Strappazzon, Flavie, Strohecker, Anne Marie, Stupack, Dwayne G, Su, Huanxing, Su, Ling-Yan, Su, Longxiang, Suarez-Fontes, Ana M, Subauste, Carlos S, Subbian, Selvakumar, Subirada, Paula V, Sudhandiran, Ganapasam, Sue, Carolyn M, Sui, Xinbing, Summers, Corey, Sun, Guangchao, Sun, Jun, Sun, Kang, Sun, Meng-Xiang, Sun, Qiming, Sun, Yi, Sun, Zhongjie, Sunahara, Karen KS, Sundberg, Eva, Susztak, Katalin, Sutovsky, Peter, Suzuki, Hidekazu, Sweeney, Gary, Symons, J David, Sze, Stephen Cho Wing, Szewczyk, Nathaniel J, Tabęcka-Łonczynska, Anna, Tabolacci, Claudio, Tacke, Frank, Taegtmeyer, Heinrich, Tafani, Marco, Tagaya, Mitsuo, Tai, Haoran, Tait, Stephen WG, Takahashi, Yoshinori, Takats, Szabolcs, Talwar, Priti, Tam, Chit, Tam, Shing Yau, Tampellini, Davide, Tamura, Atsushi, Tan, Chong Teik, Tan, Eng-King, Tan, Ya-Qin, Tanaka, Masaki, Tanaka, Motomasa, Tang, Daolin, Tang, Jingfeng, Tang, Tie-Shan, Tanida, Isei, Tao, Zhipeng, Taouis, Mohammed, Tatenhorst, Lars, Tavernarakis, Nektarios, Taylor, Allen, Taylor, Gregory A, Taylor, Joan M, Tchetina, Elena, Tee, Andrew R, Tegeder, Irmgard, Teis, David, Teixeira, Natercia, Teixeira-Clerc, Fatima, Tekirdag, Kumsal A, Tencomnao, Tewin, Tenreiro, Sandra, Tepikin, Alexei V, Testillano, Pilar S, Tettamanti, Gianluca, Tharaux, Pierre-Louis, Thedieck, Kathrin, Thekkinghat, Arvind A, Thellung, Stefano, Thinwa, Josephine W, Thirumalaikumar, VP, Thomas, Sufi Mary, Thomes, Paul G, Thorburn, Andrew, Thukral, Lipi, Thum, Thomas, Thumm, Michael, Tian, Ling, Tichy, Ales, Till, Andreas, Timmerman, Vincent, Titorenko, Vladimir I, Todi, Sokol V, Todorova, Krassimira, Toivonen, Janne M, Tomaipitinca, Luana, Tomar, Dhanendra, Tomas-Zapico, Cristina, Tomić, Sergej, Tong, Benjamin Chun-Kit, Tong, Chao, Tong, Xin, Tooze, Sharon A, Torgersen, Maria L, Torii, Satoru, Torres-López, Liliana, Torriglia, Alicia, Towers, Christina G, Towns, Roberto, Toyokuni, Shinya, Trajkovic, Vladimir, Tramontano, Donatella, Tran, Quynh-Giao, Travassos, Leonardo H, Trelford, Charles B, Tremel, Shirley, Trougakos, Ioannis P, Tsao, Betty P, Tschan, Mario P, Tse, Hung-Fat, Tse, Tak Fu, Tsugawa, Hitoshi, Tsvetkov, Andrey S, Tumbarello, David A, Tumtas, Yasin, Tuñón, María J, Turcotte, Sandra, Turk, Boris, Turk, Vito, Turner, Bradley J, Tuxworth, Richard I, Tyler, Jessica K, Tyutereva, Elena V, Uchiyama, Yasuo, Ugun-Klusek, Aslihan, Uhlig, Holm H, Ułamek-Kozioł, Marzena, Ulasov, Ilya V, Umekawa, Midori, Ungermann, Christian, Unno, Rei, Urbe, Sylvie, Uribe-Carretero, Elisabet, Üstün, Suayib, Uversky, Vladimir N, Vaccari, Thomas, Vaccaro, Maria I, Vahsen, Björn F, Vakifahmetoglu-Norberg, Helin, Valdor, Rut, Valente, Maria J, Valko, Ayelén, Vallee, Richard B, Valverde, Angela M, Van Den Berghe, Greet, Van Der Veen, Stijn, Van Kaer, Luc, Van Loosdregt, Jorg, Van Wijk, Sjoerd JL, Vandenberghe, Wim, Vanhorebeek, Ilse, Vannier-Santos, Marcos A, Vannini, Nicola, Vanrell, M Cristina, Vantaggiato, Chiara, Varano, Gabriele, Varela-Nieto, Isabel, Varga, Máté, Vasconcelos, M Helena, Vats, Somya, Vavvas, Demetrios G, Vega-Naredo, Ignacio, Vega-Rubin-De-Celis, Silvia, Velasco, Guillermo, Velázquez, Ariadna P, Vellai, Tibor, Vellenga, Edo, Velotti, Francesca, Verdier, Mireille, Verginis, Panayotis, Vergne, Isabelle, Verkade, Paul, Verma, Manish, Verstreken, Patrik, Vervliet, Tim, Vervoorts, Jörg, Vessoni, Alexandre T, Victor, Victor M, Vidal, Michel, Vidoni, Chiara, Vieira, Otilia V, Vierstra, Richard D, Viganó, Sonia, Vihinen, Helena, Vijayan, Vinoy, Vila, Miquel, Vilar, Marçal, Villalba, José M, Villalobo, Antonio, Villarejo-Zori, Beatriz, Villarroya, Francesc, Villarroya, Joan, Vincent, Olivier, Vindis, Cecile, Viret, Christophe, Viscomi, Maria Teresa, Visnjic, Dora, Vitale, Ilio, Vocadlo, David J, Voitsekhovskaja, Olga V, Volonté, Cinzia, Volta, Mattia, Vomero, Marta, Von Haefen, Clarissa, Vooijs, Marc A, Voos, Wolfgang, Vucicevic, Ljubica, Wade-Martins, Richard, Waguri, Satoshi, Waite, Kenrick A, Wakatsuki, Shuji, Walker, David W, Walker, Mark J, Walker, Simon A, Walter, Jochen, Wandosell, Francisco G, Wang, Bo, Wang, Chao-Yung, Wang, Chen, Wang, Chenran, Wang, Chenwei, Wang, Cun-Yu, Wang, Dong, Wang, Fangyang, Wang, Feng, Wang, Fengming, Wang, Guansong, Wang, Han, Wang, Hao, Wang, Hexiang, Wang, Hong-Gang, Wang, Jianrong, Wang, Jigang, Wang, Jiou, Wang, Jundong, Wang, Kui, Wang, Lianrong, Wang, Liming, Wang, Maggie Haitian, Wang, Meiqing, Wang, Nanbu, Wang, Pengwei, Wang, Peipei, Wang, Ping, Wang, Qing Jun, Wang, Qing, Wang, Qing Kenneth, Wang, Qiong A, Wang, Wen-Tao, Wang, Wuyang, Wang, Xinnan, Wang, Xuejun, Wang, Yan, Wang, Yanchang, Wang, Yanzhuang, Wang, Yen-Yun, Wang, Yihua, Wang, Yipeng, Wang, Yu, Wang, Yuqi, Wang, Zhe, Wang, Zhenyu, Wang, Zhouguang, Warnes, Gary, Warnsmann, Verena, Watada, Hirotaka, Watanabe, Eizo, Watchon, Maxinne, Wawrzyńska, Anna, Weaver, Timothy E, Wegrzyn, Grzegorz, Wehman, Ann M, Wei, Huafeng, Wei, Lei, Wei, Taotao, Wei, Yongjie, Weiergräber, Oliver H, Weihl, Conrad C, Weindl, Günther, Weiskirchen, Ralf, Wells, Alan, Wen, Runxia H, Wen, Xin, Werner, Antonia, Weykopf, Beatrice, Wheatley, Sally P, Whitton, J Lindsay, Whitworth, Alexander J, Wiktorska, Katarzyna, Wildenberg, Manon E, Wileman, Tom, Wilkinson, Simon, Willbold, Dieter, Williams, Brett, Williams, Robin SB, Williams, Roger L, Williamson, Peter R, Wilson, Richard A, Winner, Beate, Winsor, Nathaniel J, Witkin, Steven S, Wodrich, Harald, Woehlbier, Ute, Wollert, Thomas, Wong, Esther, Wong, Jack Ho, Wong, Richard W, Wong, Vincent Kam Wai, Wong, W Wei-Lynn, Wu, An-Guo, Wu, Chengbiao, Wu, Jian, Wu, Junfang, Wu, Kenneth K, Wu, Min, Wu, Shan-Ying, Wu, Shengzhou, Wu, Shu-Yan, Wu, Shufang, Wu, William KK, Wu, Xiaohong, Wu, Xiaoqing, Wu, Yao-Wen, Wu, Yihua, Xavier, Ramnik J, Xia, Hongguang, Xia, Lixin, Xia, Zhengyuan, Xiang, Ge, Xiang, Jin, Xiang, Mingliang, Xiang, Wei, Xiao, Bin, Xiao, Guozhi, Xiao, Hengyi, Xiao, Hong-Tao, Xiao, Jian, Xiao, Lan, Xiao, Shi, Xiao, Yin, Xie, Baoming, Xie, Chuan-Ming, Xie, Min, Xie, Yuxiang, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xu, Congfeng, Xu, En, Xu, Haoxing, Xu, Jing, Xu, JinRong, Xu, Liang, Xu, Wen Wen, Xu, Xiulong, Xue, Yu, Yakhine-Diop, Sokhna MS, Yamaguchi, Masamitsu, Yamaguchi, Osamu, Yamamoto, Ai, Yamashina, Shunhei, Yan, Shengmin, Yan, Shian-Jang, Yan, Zhen, Yanagi, Yasuo, Yang, Chuanbin, Yang, Dun-Sheng, Yang, Huan, Yang, Huang-Tian, Yang, Hui, Yang, Jin-Ming, Yang, Jing, Yang, Jingyu, Yang, Ling, Yang, Liu, Yang, Ming, Yang, Pei-Ming, Yang, Qian, Yang, Seungwon, Yang, Shu, Yang, Shun-Fa, Yang, Wannian, Yang, Wei Yuan, Yang, Xiaoyong, Yang, Xuesong, Yang, Yi, Yang, Ying, Yao, Honghong, Yao, Shenggen, Yao, Xiaoqiang, Yao, Yong-Gang, Yao, Yong-Ming, Yasui, Takahiro, Yazdankhah, Meysam, Yen, Paul M, Yi, Cong, Yin, Xiao-Ming, Yin, Yanhai, Yin, Zhangyuan, Yin, Ziyi, Ying, Meidan, Ying, Zheng, Yip, Calvin K, Yiu, Stephanie Pei Tung, Yoo, Young H, Yoshida, Kiyotsugu, Yoshii, Saori R, Yoshimori, Tamotsu, Yousefi, Bahman, Yu, Boxuan, Yu, Haiyang, Yu, Jun, Yu, Li, Yu, Ming-Lung, Yu, Seong-Woon, Yu, Victor C, Yu, W Haung, Yu, Zhengping, Yu, Zhou, Yuan, Junying, Yuan, Ling-Qing, Yuan, Shilin, Yuan, Shyng-Shiou F, Yuan, Yanggang, Yuan, Zengqiang, Yue, Jianbo, Yue, Zhenyu, Yun, Jeanho, Yung, Raymond L, Zacks, David N, Zaffagnini, Gabriele, Zambelli, Vanessa O, Zanella, Isabella, Zang, Qun S, Zanivan, Sara, Zappavigna, Silvia, Zaragoza, Pilar, Zarbalis, Konstantinos S, Zarebkohan, Amir, Zarrouk, Amira, Zeitlin, Scott O, Zeng, Jialiu, Zeng, Ju-Deng, Žerovnik, Eva, Zhan, Lixuan, Zhang, Bin, Zhang, Donna D, Zhang, Hanlin, Zhang, Hong, Zhang, Honghe, Zhang, Huafeng, Zhang, Huaye, Zhang, Hui, Zhang, Hui-Ling, Zhang, Jianbin, Zhang, Jianhua, Zhang, Jing-Pu, Zhang, Kalin YB, Zhang, Leshuai W, Zhang, Lin, Zhang, Lisheng, Zhang, Lu, Zhang, Luoying, Zhang, Menghuan, Zhang, Peng, Zhang, Sheng, Zhang, Wei, Zhang, Xiangnan, Zhang, Xiao-Wei, Zhang, Xiaolei, Zhang, Xiaoyan, Zhang, Xin, Zhang, Xinxin, Zhang, Xu Dong, Zhang, Yang, Zhang, Yanjin, Zhang, Yi, Zhang, Ying-Dong, Zhang, Yingmei, Zhang, Yuan-Yuan, Zhang, Yuchen, Zhang, Zhe, Zhang, Zhengguang, Zhang, Zhibing, Zhang, Zhihai, Zhang, Zhiyong, Zhang, Zili, Zhao, Haobin, Zhao, Lei, Zhao, Shuang, Zhao, Tongbiao, Zhao, Xiao-Fan, Zhao, Ying, Zhao, Yongchao, Zhao, Yongliang, Zhao, Yuting, Zheng, Guoping, Zheng, Kai, Zheng, Ling, Zheng, Shizhong, Zheng, Xi-Long, Zheng, Yi, Zheng, Zu-Guo, Zhivotovsky, Boris, Zhong, Qing, Zhou, Ao, Zhou, Ben, Zhou, Cefan, Zhou, Gang, Zhou, Hao, Zhou, Hong, Zhou, Hongbo, Zhou, Jie, Zhou, Jing, Zhou, Jiyong, Zhou, Kailiang, Zhou, Rongjia, Zhou, Xu-Jie, Zhou, Yanshuang, Zhou, Yinghong, Zhou, Yubin, Zhou, Zheng-Yu, Zhou, Zhou, Zhu, Binglin, Zhu, Changlian, Zhu, Guo-Qing, Zhu, Haining, Zhu, Hongxin, Zhu, Hua, Zhu, Wei-Guo, Zhu, Yanping, Zhu, Yushan, Zhuang, Haixia, Zhuang, Xiaohong, Zientara-Rytter, Katarzyna, Zimmermann, Christine M, Ziviani, Elena, Zoladek, Teresa, Zong, Wei-Xing, Zorov, Dmitry B, Zorzano, Antonio, Zou, Weiping, Zou, Zhen, Zou, Zhengzhi, Zuryn, Steven, Zwerschke, Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
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phagophore ,vacuole ,Autophagosome ,neurodegeneration ,Autophagosomes ,Autophagy-Related Proteins ,flux ,macroautophagy ,stress ,LC3 ,lysosome ,Autophagy ,cancer ,Animals ,Humans ,Biological Assay ,Lysosomes ,Biomarkers - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
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21. Driving force of zero-macroscopic-strain deformation twinning in face-centred-cubic metals
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Xie, Hongxian, Wei, Gaobing, Lu, Yuanfang, Du, Junping, Yin, Fuxing, Lu, Guang-Hong, and Ogata, Shigenobu
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Condensed Matter::Materials Science - Abstract
Zero-macroscopic-strain deformation twinning (ZMS-DT) is widely observed in many face-centred-cubic (FCC) metals and alloys. However, the driving force of ZMS-DT is a controversial issue and has not been fully clarified for a long time. Based on molecular dynamics simulations to various FCC metals, we found that ZMS-DT, i.e. ��3{112} incoherent twin boundary migration can be driven by simultaneously applying both normal and shear strains/stresses to the twin boundary (TB), and changing the sign of the normal or the shear strain/stress can change the direction of the incoherent TB migration. With analysing the results of atomistic strain energy calculation and anisotropic elasticity theory, we revealed the strain energy imbalance, which originates from elastic anisotropic response of materials, between the two sides of the twin boundary under normal���shear strain (or stress) coupling condition essentially drives the TB migration and twin growth. Eventually, we deduce that the elastic anisotropy ratio can be one of the key material constants which affect the twinnability of FCC metals.
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- 2021
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22. Additional file 3 of Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways
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Xie, Ming-Zhang, Guo, Chun, Dong, Jia-Qi, Zhang, Jie, Sun, Ke-Tao, Lu, Guang-Jian, Wang, Lei, Bo, De-Ying, Jiao, Lu-Yang, and Zhao, Guo-An
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Additional file 3. Original, Unprocessed Versions of Effect of Glyoxal (GX) on the Redox State of Trx1.
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- 2021
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23. Additional file 4 of Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways
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Xie, Ming-Zhang, Guo, Chun, Dong, Jia-Qi, Zhang, Jie, Sun, Ke-Tao, Lu, Guang-Jian, Wang, Lei, Bo, De-Ying, Jiao, Lu-Yang, and Zhao, Guo-An
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Additional file 4. Original, Unprocessed Versions of Effect of Glyoxal (GX) on MAP Kinase Pathways.
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- 2021
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24. Additional file 2 of Genome-wide association study reveals the genetic architecture of root hair length in maize
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Liu, Lin, Jiang, Lu-Guang, Luo, Jin-Hong, Xia, Ai-Ai, Chen, Li-Qun, and He, Yan
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Additional files 2: 0 Figure S2. The allele effects of significant SNPs located around representative genes for root hair length. (a–d; i-l) Regional plots showing association mapping results for SNPs located around GRMZM2G100288 (a), GRMZM2G147446 (b), GRMZM2G078013 (c), GRMZM2G000471 (d), GRMZM2G064644 (i), AC193598.3_FG002 (j), GRMZM2G180244 (k), GRMZM2G091579 (l). (e–h; m-p) Allele effects of the most significant SNPs for root hair traits. (e) GRMZM2G100288, (f) GRMZM2G147446, (g) GRMZM2G078013, (h) GRMZM2G000471, (m) GRMZM2G064644, (n) AC193598.3_FG002, (o) GRMZM2G180244, (p) GRMZM2G091579. Each dot represents an SNP. The horizontal dashed black line represents the significant threshold –log10(P) = 5.2. *Significant at P ≤ 0.05; **significant at P ≤ 0.01.
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- 2021
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25. Additional file 2 of Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways
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Xie, Ming-Zhang, Guo, Chun, Dong, Jia-Qi, Zhang, Jie, Sun, Ke-Tao, Lu, Guang-Jian, Wang, Lei, Bo, De-Ying, Jiao, Lu-Yang, and Zhao, Guo-An
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Additional file 2. Original, Unprocessed Versions of Double Srand Break (DSB) Induction.
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- 2021
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26. Additional file 1 of Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways
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Xie, Ming-Zhang, Guo, Chun, Dong, Jia-Qi, Zhang, Jie, Sun, Ke-Tao, Lu, Guang-Jian, Wang, Lei, Bo, De-Ying, Jiao, Lu-Yang, and Zhao, Guo-An
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congenital, hereditary, and neonatal diseases and abnormalities ,hemic and lymphatic diseases ,nutritional and metabolic diseases - Abstract
Additional file 1. siRNA-mediated Knockdown of FANCA.
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- 2021
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27. A natural single-nucleotide polymorphism variant in sulfite reductase influences sulfur assimilation in maize
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Weiming Tan, Aiai Xia, Yan He, Qi Wang, Zhen Li, Xiaolei Zhang, Lu-Guang Jiang, Joseph M. Jez, and Wang Yan
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Genetics ,education.field_of_study ,Physiology ,Population ,chemistry.chemical_element ,Single-nucleotide polymorphism ,Plant Science ,Biology ,Sulfur ,Polymorphism, Single Nucleotide ,Zea mays ,Sulfite reductase ,Metabolic pathway ,Sulfur assimilation ,chemistry ,Oxidoreductases Acting on Sulfur Group Donors ,Prospective Studies ,Allele ,education ,Gene ,Genome-Wide Association Study - Abstract
Plants absorb sulfur from the environment and assimilate it into suitable forms for the biosynthesis of a broad range of molecules. Although the biochemical pathway of sulfur assimilation is known, how genetic differences contribute to natural variation in sulfur assimilation remains poorly understood. Here, using a genome-wide association study, we uncovered a single-nucleotide polymorphism (SNP) variant in the sulfite reductase (SiR) gene that was significantly associated with SiR protein abundance in a maize natural association population. We also demonstrated that the synonymous C to G base change at SNP69 may repress translational activity by altering messenger RNA secondary structure, which leads to reduction in ZmSiR protein abundance and sulfur assimilation activity. Population genetic analyses showed that the SNP69C allele was likely a variant occurring after the initial maize domestication and accumulated with the spread of maize cultivation from tropical to temperate regions. This study provides the first evidence that genetic polymorphisms in the exon of ZmSiR could influence the protein abundance through a posttranscriptional mechanism and in part contribute to natural variation in sulfur assimilation. These findings provide a prospective target to improve maize varieties with proper sulfur nutrient levels assisted by molecular breeding and engineering.
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- 2020
28. PointINet: Point Cloud Frame Interpolation Network
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Fan Lu, Guang Chen, Sanqing Qu, Zhijun Li, Yinlong Liu, Alois Knoll
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ddc - Published
- 2020
29. Additional file 4 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
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Additional file 4:Figure S4. Bacterial two-hybrid experiment and pull-down assay demonstrated interaction between FliN and PilG or PilH. (A) Bacterial two-hybrid experiment showed that PilG and PilH interacted with FliN protein. The reporter strain XL1-Blue MRF′ with different plasmid pairs was grown on no selective plates and double-selective indicator plates containing 5 mM 3-AT and 12.5 μg ml− 1 streptomycin. Protein-protein interactions activate the expression of addA and HIS3 genes within the reporter gene cassette of the reporter strain, resulting in resistance to streptomycin and 3-AT. (B) The pull-down assay demonstrated interaction between FliN and PilG or PilH in vitro. Lanes: 1, crude extract of BL21/pET30a after induction with IPTG; 2, crude extract of BL21/pET30a-PilG after induction with IPTG; 3, affinity-purified His6- PilG protein; 4, crude extract of BL21/pET30a- PilH; 5, affinity-purified His6- PilH protein; 6, crude extract of M15/pQE30 after induction with IPTG; 7, crude extract of M15/pQE30- FliN after induction with IPTG; 8, affinity-purified His6- FliN protein; 9, pull-down of protein His6- PilG by FliN; 10, pull-down of protein His6- PilH by FliN; 11, pull-down of protein His6- HpaR1 by FliN. M, molecular mass marker.
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- 2020
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30. Additional file 8 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 8:Table S3. The differential expressed genes of the pilH mutant strain ∆pilH in the rich medium NYGB.
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- 2020
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31. Additional file 7 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
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Additional file 7:Table S2. The differential expressed genes of the pilG mutant strain ∆pilG in the rich medium NYGB.
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- 2020
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32. Additional file 3 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 3:Figure S3. Confirmation of RNA-Seq gene expression data by semi-quantitative RT-PCR. Note: Part of the differential expressed genes were performed to confirm the results of RNA-Seq by semi quantitative reverse-transcription PCR (semi RT-PCR). The expression levels of gene transcripts were calculated though the absolute value of log2 fold change =1(equivalent to a fold change of 2). ↑: up-regulated; ↓: down-regulated.
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- 2020
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33. Additional file 9 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 9:Table S4. The overlap of differential expressed genes of the pilG mutant strain ∆pilG and the pilH mutant strain ∆pilH in the rich medium NYGB.
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- 2020
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34. Additional file 6 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
- Author
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 6:Table S1. Bacterial strains and plasmids used in this work
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- 2020
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35. Additional file 10 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 10:Table S5. Primers used in this study.
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- 2020
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36. Additional file 2 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
- Author
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 2:Figure S2. PilH positively regulates EPS production but PilG not, and they have no effect on the growth in NY medium. (A) Analysis of EPS production on plates. The strains were grown and diluted to OD600 of 1, and then 3 μl diluted culture was inoculated onto the NY plates containing 2% glucose and 2.0% agar. The results were observed after 5 days of incubation at 28 °C. (B) Production of EPS in Xcc strains. Mean weight of EPS extracted from the wild type strain, the pilG mutant, the pilH mutant and the corresponding complemented strains. (C) Growth curve of Xcc strains in NY medium. The strains were inoculated into NYG medium with the same final density of 0.01, growth of the strains was diluted and plated on NYG plates at intervals of 4 h. The living cells were counted after 3 days of incubation at 28 °C. Significance was tested by Student’s t test (* and ** represent significance at P
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- 2020
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37. Additional file 5 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
- Author
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
- Abstract
Additional file 5:Figure S5. Mutation in gene pilI influences swarming and swimming motility, but mutation in colS not. (A) Strains were stabbed into ‘swim’ plate (0.03% Bacto peptone, 0.03% yeast extract and 0.28% agar) then incubated at 28 °C for 3 days or inoculated onto ‘swarm’ plate (NY plate containing 2% glucose and 0.6% agar) then incubated at 28 °C for 3 days. (B) The diameter of the colony 8004, ΔpilI, CpilI, ΔcolS and CcolS on swimming and swarming plates. Significance was tested by Student’s t test (* and ** represent significance at P
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- 2020
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38. Additional file 1 of PilG and PilH antagonistically control flagellum-dependent and pili-dependent motility in the phytopathogen Xanthomonas campestris pv. campestris
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Qi, Yan-Hua, Huang, Li, Liu, Guo-Fang, Leng, Ming, and Lu, Guang-Tao
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Additional file 1:Figure S1. Identification of PilG and PilH in Xcc. (A) Sequence alignment of PilG in Xcc and other bacteria. The GenBank number of PilG homologue in Xanthomonas campestris pv. campestris is AAY48253; that in Pseudomonas aeruginosa is NP_249099; that in Lysobacter enzymogenes is BAV96685; that in Acinetobacter baumnnii is ABO13221. (B) Sequence alignment of PilH in Xcc and other bacteria. The GenBank number of PilG homologue in Xanthomonas campestris pv. campestris is AAY48254; that in Pseudomonas aeruginosa is NP_249100; that in Lysobacter enzymogenes is BAV96686; that in Acinetobacter baumnnii is ABO13220. (C) Sequence alignment of PilG, PilH and CheY (ID: AAY49356) in Xanthomonas campestris pv. campestris with CheYEc (ID: 190906748) in E. coli.
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- 2020
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39. Hydrothermal synthesis of m-BiVO4 and m-BiVO4/BiOBr with various facets and morphologies and their photocatalytic performance under visible light
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Zou Xuejun, Lu Guang, and Wang Fei
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Materials science ,business.industry ,Mechanical Engineering ,Metals and Alloys ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,Hydrothermal circulation ,0104 chemical sciences ,chemistry.chemical_compound ,Optics ,chemistry ,X-ray photoelectron spectroscopy ,Chemical engineering ,Mechanics of Materials ,Materials Chemistry ,Rhodamine B ,Photocatalysis ,Hydrothermal synthesis ,0210 nano-technology ,business ,High-resolution transmission electron microscopy ,Visible spectrum - Abstract
In this work, the 3D four petaled flower-like, cube-like and rod-like m-BiVO4 samples and four corners star-like m-BiVO4/BiOBr heterojunctions with various exposed (040) facets were successfully prepared by a hydrothermal method. The microstructure and the crystalline structure of as-prepared m-BiVO4 and m-BiVO4/BiOBr heterojunctions influenced by molar ratio of Br:V had been investigated by XRD, SEM, TEM, HRTEM, N2 absorption–desorption, XPS, PL and DRS. In addition, the photocatalytic performance of the prepared m-BiVO4 and m-BiVO4/BiOBr heterojunctions were evaluated by monitoring the degradation of Rhodamine B (RhB) contained wastewater under visible light irradiation. The highest photocatalytic degradation efficiency can be achieved for the m-BiVO4/BiOBr heterojunctions with Br:V molar ratio of 3:1, which was attributed to the predominately exposed (040) facets of m-BiVO4 and high exposing proportion of (001) facets of BiOBr, the highest BET, the lowest Eg and the worst recombination rate of photo-generated electron-hole pairs.
- Published
- 2017
40. Birth of puppies of predetermined sex after artificial insemination with a low number of sex-sorted, frozen-thawed spermatozoa in field conditions
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Li Liguang, Bin Wang, Yue-Jun Zhang, Wei Yunfang, Li Jing, Mao Aiguo, Chen Fangliang, Li Feixiang, Wan Jiusheng, Lu-Guang Cheng, Tang Shusheng, Xu Tao, and Chen Chao
- Subjects
Pregnancy ,030219 obstetrics & reproductive medicine ,Artificial insemination ,medicine.medical_treatment ,0402 animal and dairy science ,Sperm washing ,Semen ,04 agricultural and veterinary sciences ,General Medicine ,Biology ,Insemination ,medicine.disease ,040201 dairy & animal science ,Sperm ,Andrology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Weaning ,General Agricultural and Biological Sciences ,Sex ratio - Abstract
The aim of this study was to evaluate fertility and sex ratios after artificial insemination in dogs under field conditions. Semen was cryopreserved as unsorted (control) or was separated into X- and Y-chromosome-bearing sperm using a cell sorter. Sixty female dogs were inseminated with frozen-thawed spermatozoa of 100 × 106 unsorted (a dose in practice) and 4 × 106 sorted (X and Y group, respectively). A total of 20 dogs became pregnant and 126 puppies were born from the three groups. The percentage of parturition was similar for the X (5/20; 25.0%) and Y (4/20; 20.0%) group (P > 0.05), but lower than controls (11/20; 55.0%) (P < 0.05). Ultimately 28 out of the 32 puppies produced from X group were female (87.5%) and 19/22 (86.4%) puppies of Y group were male. In contrast, sex ratio (51.4% to 48.6%) in the control was significantly different from the X, Y group (P < 0.05). However, male and female puppies in the control had similar birth weights and weaning weights to those from the X and Y groups. This preliminary information indicated that normal puppies of predicted sex can be produced with low numbers of sorted cryopreserved dog spermatozoa at a farm level, making sperm-sexing technology potentially applicable for elite breeding units.
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- 2017
41. Putting Stem Cells on a Low-Fat Diet Switches Their Pluripotent State
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Ng Shyh-Chang, Zongmin Jiang, Lu Guang, and Lei Li
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Pluripotent Stem Cells ,Cellular differentiation ,Cell ,Biology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,medicine ,Humans ,Epigenetics ,Induced pluripotent stem cell ,Diet, Fat-Restricted ,Embryonic Stem Cells ,030304 developmental biology ,0303 health sciences ,Cell Differentiation ,Cell Biology ,Low fat diet ,Embryonic stem cell ,Lipids ,Cell biology ,medicine.anatomical_structure ,Molecular Medicine ,Stem cell ,030217 neurology & neurosurgery - Abstract
Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain incompletely defined. Here we demonstrate that the widely used Essential 8 minimal medium (E8) captures hPSCs at a naive-to-primed intermediate state of pluripotency expressing several naive-like developmental, bioenergetic, and epigenomic features despite providing primed-state-sustaining growth factor conditions. Transcriptionally, E8 hPSCs are marked by activated lipid biosynthesis and suppressed MAPK/TGF-β gene expression, resulting in endogenous ERK inhibition. These features are dependent on lipid-free culture conditions and are lost upon lipid exposure, whereas short-term pharmacological ERK inhibition restores naive-to-primed intermediate traits even in the presence of lipids. Finally, we identify de novo lipogenesis as a common transcriptional signature of E8 hPSCs and the pre-implantation human epiblast in vivo. These findings implicate exogenous lipid availability in regulating human pluripotency and define E8 hPSCs as a stable, naive-to-primed intermediate (NPI) pluripotent state.
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- 2019
42. ACR883391 Supplemetal Material - Supplemental material for Similarity and diversity of spontaneous brain activity in functional dyspepsia subtypes
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Rongfeng Qi, Shi, Zhao, Yifei Weng, Yulin Yang, Yifei Zhou, Surento, Wesley, Lu, Guang Ming, Fangyu Wang, Zhang, Long Jiang, and Liu, Chang
- Subjects
110320 Radiology and Organ Imaging ,FOS: Clinical medicine - Abstract
Supplemental material, ACR883391 Supplemetal Material for Similarity and diversity of spontaneous brain activity in functional dyspepsia subtypes by Rongfeng Qi, Zhao Shi, Yifei Weng, Yulin Yang, Yifei Zhou, Wesley Surento, Guang Ming Lu, Fangyu Wang, Long Jiang Zhang and Chang Liu in Acta Radiologica
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- 2019
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43. Research on flow field characteristics of compound jet pump
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Yang Zhao, Wang Bo, Xu Yong, Lu-guang Ran, and Yun-liang Chen
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Materials science ,law ,Injector ,Mechanics ,Flow field ,law.invention - Published
- 2018
44. Effect of drying temperatures on structural performance and photocatalytic activity of BiOCl synthesized by a soft chemical method
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Lu Guang, Zou Xuejun, and Wang Hui
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Materials science ,02 engineering and technology ,Chromophore ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Photochemistry ,01 natural sciences ,0104 chemical sciences ,Electronic, Optical and Magnetic Materials ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Phase (matter) ,Materials Chemistry ,Ceramics and Composites ,Rhodamine B ,Photocatalysis ,Degradation (geology) ,Physical and Theoretical Chemistry ,0210 nano-technology ,Photodegradation ,Visible spectrum ,Nanosheet - Abstract
A group of BiOCl photocatalysts with different drying temperatures were prepared by a soft chemical method. The effects of drying temperatures on the crystalline phase, morphology, surface area and optical property of as-prepared samples were investigated in detail by XRD, SEM, N2 absorption–desorption and DRS. Moreover, their photocatalytic activities on the degradation of rhodamine B were evaluated under visible light irradiation. It was found that the sample dried at 120 °C had the best photocatalytic activity, which was mainly attributed to the highest exposing proportion of {001} facets correspond to BiOCl, largest BET and minimum bandgap. The degradation mechanism was explored that superoxide radicals were mainly contributed to the degradation of chromophore, however, holes and hydroxyl were mainly contributed to the photo degradation. Moreover, holes and hydroxyl dominated the degradation of RhB.
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- 2016
45. Differential response of immortalized human amnion mesenchymal and epithelial cells against oxidative stress
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Toshio Nikaido, Qing-Li Zhao, Motonori Okabe, Lu Guang Han, Mati Ur Rehman, Takashi Kondo, Toshiko Yoshida, and Chika Soko
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0301 basic medicine ,Cell Survival ,NF-E2-Related Factor 2 ,SOD2 ,Apoptosis ,medicine.disease_cause ,Biochemistry ,Antioxidants ,Cell Line ,Mesoderm ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,medicine ,Humans ,Viability assay ,Amnion ,chemistry.chemical_classification ,Reactive oxygen species ,Caspase 8 ,Caspase 3 ,Superoxide Dismutase ,X-Rays ,Mesenchymal stem cell ,Epithelial Cells ,Hydrogen Peroxide ,Fibroblasts ,Cell biology ,Oxidative Stress ,030104 developmental biology ,medicine.anatomical_structure ,chemistry ,Amniotic epithelial cells ,Reactive Oxygen Species ,Oxidation-Reduction ,030217 neurology & neurosurgery ,Intracellular ,Oxidative stress ,Heme Oxygenase-1 ,Signal Transduction - Abstract
Cells are equipped with various antioxidant defense factors to antagonize insults from reactive oxygen species (ROS), thus the antioxidant capacity has been characterized by a variety of cellular responses during the pathophysiological processes. Amniotic cells have been extensively applied in clinical practice for burn treatment, corneal repair, and tissue regeneration. However, the antioxidative properties of amniotic cells have not yet been fully understood. Therefore, the current study was aimed to observe the response of amniotic cells against ROS stimuli, and to investigate the underlying molecular mechanisms. The immortalized human amniotic mesenchymal cells (iHAMs) and immortalized human amniotic epithelial cells (iHAEs) were used. The human skin fibroblast (HSF) was used as a control cell line. Changes in intracellular ROS generation, cell viability, and cellular morphology were investigated to reveal the response of amniotic cells against oxidative stresses induced by x-rays and hydrogen peroxide. In addition, expression of apoptosis-related proteins and response to antioxidative stress was also examined. The intracellular ROS level and cell apoptosis in iHAMs was remarkably increased. iHAEs showed relatively high resistance to ROS stimulation, which can be attributed to the high SOD2 expression and up-regulation of Nrf2, HO-1 after x-rays exposure. In contrast, iHAMs were found sensitive to oxidative damage. Expression of caspase-3, caspase-8 and BAX was increased, whereas down-regulation of Bcl-xL, Nrf2, HO-1, and TrxR-1. Taken together, findings have highlighted the characterization of response of amniotic derived epithelial and mesenchymal cells to oxidative stress. In physiological processes, iHAMs may play an important role to maintain the homeostasis of the pregnancy environment. However, under oxidative stimulations, iHAEs provides protection against oxidative damage in amnion tissue.
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- 2018
46. Supplemental table3 - Supplemental material for Computer-assisted detection of acute pulmonary embolism at CT pulmonary angiography in children and young adults: a diagnostic performance analysis
- Author
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Tang, Chun Xiang, Zhou, Chang Sheng, Schoepf, Uwe Joseph, Mastrodicasa, Domenico, Duguay, Taylor, Cline, Anna, Zhao, Yan E, Lu, Li, Li, Xie, Tao, Shu Min, Lu, Meng Jie, Lu, Guang Ming, and Zhang, Long Jiang
- Subjects
110320 Radiology and Organ Imaging ,FOS: Clinical medicine - Abstract
Supplemental material, Supplemental table3 for Computer-assisted detection of acute pulmonary embolism at CT pulmonary angiography in children and young adults: a diagnostic performance analysis by Chun Xiang Tang, Chang Sheng Zhou, Uwe Joseph Schoepf, Domenico Mastrodicasa, Taylor Duguay, Anna Cline, Yan E Zhao, Li Lu, Xie Li, Shu Min Tao, Meng Jie Lu, Guang Ming Lu and Long Jiang Zhang in Acta Radiologica
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- 2018
- Full Text
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47. Additional file 4: of Novel mutations of PKD genes in Chinese patients suffering from autosomal dominant polycystic kidney disease and seeking assisted reproduction
- Author
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He, Wen-Bin, Xiao, Wen-Juan, Yue-Qiu Tan, Zhao, Xiao-Meng, Li, Wen, Zhang, Qian-Jun, Chang-Gao Zhong, Li, Xiu-Rong, Hu, Liang, Lu, Guang-Xiu, Lin, Ge, and Du, Juan
- Abstract
Table S4. Primers used in PCR of PKD2 and GANAB. (DOC 53Â kb)
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- 2018
- Full Text
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48. Additional file 1: of Novel mutations of PKD genes in Chinese patients suffering from autosomal dominant polycystic kidney disease and seeking assisted reproduction
- Author
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He, Wen-Bin, Xiao, Wen-Juan, Yue-Qiu Tan, Zhao, Xiao-Meng, Li, Wen, Zhang, Qian-Jun, Chang-Gao Zhong, Li, Xiu-Rong, Hu, Liang, Lu, Guang-Xiu, Lin, Ge, and Du, Juan
- Subjects
urologic and male genital diseases ,female genital diseases and pregnancy complications - Abstract
Table S1. Primers used in long-range PCR of PKD1 homologous regions. (DOC 37Â kb)
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- 2018
- Full Text
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49. Supplemental Figures - Supplemental material for Computer-assisted detection of acute pulmonary embolism at CT pulmonary angiography in children and young adults: a diagnostic performance analysis
- Author
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Tang, Chun Xiang, Zhou, Chang Sheng, Schoepf, Uwe Joseph, Mastrodicasa, Domenico, Duguay, Taylor, Cline, Anna, Zhao, Yan E, Lu, Li, Li, Xie, Tao, Shu Min, Lu, Meng Jie, Lu, Guang Ming, and Zhang, Long Jiang
- Subjects
110320 Radiology and Organ Imaging ,FOS: Clinical medicine - Abstract
Supplemental material, Supplemental Figures for Computer-assisted detection of acute pulmonary embolism at CT pulmonary angiography in children and young adults: a diagnostic performance analysis by Chun Xiang Tang, Chang Sheng Zhou, Uwe Joseph Schoepf, Domenico Mastrodicasa, Taylor Duguay, Anna Cline, Yan E Zhao, Li Lu, Xie Li, Shu Min Tao, Meng Jie Lu, Guang Ming Lu and Long Jiang Zhang in Acta Radiologica
- Published
- 2018
- Full Text
- View/download PDF
50. Supplemental table2 - Supplemental material for Computer-assisted detection of acute pulmonary embolism at CT pulmonary angiography in children and young adults: a diagnostic performance analysis
- Author
-
Tang, Chun Xiang, Zhou, Chang Sheng, Schoepf, Uwe Joseph, Mastrodicasa, Domenico, Duguay, Taylor, Cline, Anna, Zhao, Yan E, Lu, Li, Li, Xie, Tao, Shu Min, Lu, Meng Jie, Lu, Guang Ming, and Zhang, Long Jiang
- Subjects
110320 Radiology and Organ Imaging ,FOS: Clinical medicine - Abstract
Supplemental material, Supplemental table2 for Computer-assisted detection of acute pulmonary embolism at CT pulmonary angiography in children and young adults: a diagnostic performance analysis by Chun Xiang Tang, Chang Sheng Zhou, Uwe Joseph Schoepf, Domenico Mastrodicasa, Taylor Duguay, Anna Cline, Yan E Zhao, Li Lu, Xie Li, Shu Min Tao, Meng Jie Lu, Guang Ming Lu and Long Jiang Zhang in Acta Radiologica
- Published
- 2018
- Full Text
- View/download PDF
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