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A través del paso del tiempo han surgido alternativas para la generación de energía, una de ellas es la celda de combustible microbianas, mediante este método se aprovecha la energía residual de los microorganismos, sin embargo, ha presentado deficiencias en su aplicación debido al rápido uso del sustrato por parte de los microbios para generar energía eléctrica. En este artículo se propone la implementación de celdas de combustible microbianas de plantas, las cuales agregan microorganismos al sistema de generación de energía y a través del proceso de fotosíntesis propician una interacción benéfica para el sustrato, permitiendo conservar sus propiedades, necesarias para la generación de energía eléctrica. Para almacenar la energía generada por la P-MFC es necesario conocer el comportamiento del voltaje, para así desarrollar el método más eficiente de recolección de energía diseñando un dispositivo de menor tamaño, dando la posibilidad crear un prototipo menos invasivo para la planta.

El renacer de la historia constitucional en la España el siglo XXI ha venido promovido en buena parte por la conmemoración del bicentenario de las Cortes de Cádiz y la Constitución de 1812, pero también por la eclosión del problema de la articulación territorial, lo que ha reanimado el estudio de las instituciones representativas en las antiguas comunidades forales. Además de examinar la producción historiográfica en lo que llevamos de siglo, se exponen también los perjuicios que causan las malas prácticas de los investigadores menos respetuosos con la propiedad intelectual.

Aim To describe the role of multicolour reflectance images (MCI) in the phenotypic diagnosis of inherited retinal disorders (IRDs). Methods A retrospective review of consecutive patients affected by IRDs examined with MCI techniques from January to December 2019 at a tertiary care referral centre. All patients had MCI, fundus autofluorescence and optical coherence tomography taken at the same time point. The ability of each modality to highlight clinical features was assessed. Lesions’ size was also measured and compared among imaging modalities. Results Thirty eyes of 15 patients were included in the study, 6 males and 9 females, with a mean age of 44 years (range: 19–57.5). The most frequent clinical diagnosis were: pattern dystrophies, and late-onset retinal degeneration. Next-generation or Sanger sequencing analysis was carried out in all patients. Blue and green reflectance were relevant in highlighting peripheral mottling in fundus albipunctatus, pseudoreticular drusen in late-onset retinal degeneration, parafoveal hyperreflective area in bull's eye maculopathy and crystals in Bietti's crystalline dystrophy. Likewise, it is to mention the ability of infrared reflectance to detect hyperreflective patches in posterior pole in neurofibromatosis type 1 and retinal changes in pattern dystrophies and cone dystrophies. Conclusion Multicolour imaging technique enables the detection of clinical features that could be overlooked by other imaging modalities, allowing accurate phenotypic characterisation of IRDs and guiding genetic diagnose, and may become a meaningful monitoring tool for future treatments.

When exploring relationships among clinical measures and patient-reported outcome measures in adults with convergence insufficiency, worse symptoms (Convergence Insufficiency Symptom Survey [CISS] score) seemed to be correlated with worse reading function domain score (Adult Strabismus-20 quality-of-life questionnaire). After treatment, improved symptoms were associated with improved reading function quality of life.This study aimed to explore relationships between clinical measures and patient-reported outcome measures in adults undergoing treatment for symptomatic convergence insufficiency.In a prospective multicenter observational study, we evaluated adults with symptomatic convergence insufficiency (i.e., clinical measures of near exodeviation, receded near point of convergence, reduced near positive fusional vergence; CISS score ≥21). Fifty-seven participants treated with vision therapy/exercises (n = 35) or base-in prism (n = 22) were analyzed. Spearman correlation coefficients ( R ) were used to assess associations among the three clinical measures and patient-reported outcome measures (CISS, Diplopia Questionnaire, four Adult Strabismus-20 quality-of-life domains) before treatment (baseline) and after 10 weeks and 1 year. Associations were interpreted to be present when the lower limit of the 95% confidence interval (CI) was moderate to strong ( R ≥ 0.4).Among multiple exploratory analyses, the only moderate to strong baseline correlation was between worse CISS and worse Adult Strabismus-20 reading function scores ( R = 0.62; 95% CI, 0.43 to 0.76). Regarding change in measures with treatment, the only moderate to strong correlations were between improved CISS and improved Adult Strabismus-20 reading function scores for prism at 10 weeks ( R = 0.78; 95% CI, 0.52 to 0.91) and 1 year ( R = 0.85; 95% CI, 0.65 to 0.94) and for vision therapy/exercises at 1 year ( R = 0.78; 95% CI, 0.57 to 0.89).In exploratory analyses, we found positive correlations between CISS symptom scores and reading function quality-of-life scores. The absence of correlations between symptoms and individual clinical measures is consistent with clinical experience that, in convergence insufficiency, symptoms and clinical findings can be discordant.

In México, basal cell carcinoma is the most frequent skin cancer, with great implications in the health sector. The management of choice is resection in this type of lesions, which at the same time require reconstruction of the affected area. Currently there are several techniques for this type of reconstruction. In this case, a 78-year-old male patient underwent resection of a lesion on the dorsum of the nose with reconstruction with a paramedian forehead flap, without complications.

In the present work it is studied the predictive ability of NIRS for the estimation of chemical composition (n=171) and organic matter digestibility (n=71) of whole plants forage sorghum and morphological components, being developed empirical equations based on chemical parameters to estimate the organic matter digestibility (OMD) values and compared the predictive ability of empirical models vs. NIRS equations. The predictive ability of NIRS models for estimating the OMD and chemical composition showed high reliability, according to the coefficient of determination in external validation (r²≥0.90), whilst the ratio of the standard deviation of the original data to standard error of external validation (RPD) values were higher than 3.0 for all parameters studied. Applying NIRS models to the prediction of OMD of whole plants and morphological components of forage sorghum led to the reduction in the standard error of external validation, in comparison of the best empirical model based on the chemical composition of samples (from ±3.9 to ±1.9%). It is concluded that the NIRS equations developed in the present work are valuable tools for the fast and accurate assessment of the nutritive value of the whole plant and components of forage sorghum.

Acute febrile illness is a common presentation for patients at hospitals globally. Assays that can diagnose a variety of common pathogens in blood could help to establish a diagnosis for targeted disease management. We aimed to evaluate the performance of the BioFire Global Fever Panel (GF Panel), a multiplex nucleic acid amplification test performed on whole blood specimens run on the BioFire FilmArray System, in the diagnosis of several pathogens that cause acute febrile illness.We did a prospective, multicentre, cross-sectional diagnostic accuracy study to evaluate the GF Panel. Consenting adults and children older than 6 months presenting with fever in the previous 2 days were enrolled consecutively in sub-Saharan Africa (Ghana, Kenya, Tanzania, Uganda), southeast Asia (Cambodia, Thailand), central and South America (Honduras, Peru), and the USA (Washington, DC; St Louis, MO). We assessed the performance of six analytes (chikungunya virus, dengue virus [serotypes 1-4], Leptospira spp, Plasmodium spp, Plasmodium falciparum, and Plasmodium vivax or Plasmodium ovale) on the GF Panel. The performance of the GF Panel was assessed using comparator PCR assays with different primers followed by bidirectional sequencing on nucleic acid extracts from the same specimen. We calculated the positive percent agreement and negative percent agreement of the GF Panel with respect to the comparator assays. This study is registered with ClinicalTrials.gov, NCT02968355.From March 26, 2018, to Sept 30, 2019, 1965 participants were enrolled at ten sites worldwide. Of the 1875 participants with analysable results, 980 (52·3%) were female and the median age was 22 years (range 0-100). At least one analyte was detected in 657 (35·0%) of 1875 specimens. The GF Panel had a positive percent agreement for the six analytes evaluated as follows: chikungunya virus 100% (95% CI 86·3-100), dengue virus 94·0% (90·6-96·5), Leptospira spp 93·8% (69·8-99·8), Plasmodium spp 98·3% (96·3-99·4), P falciparum 92·7% (88·8-95·6), and P vivax or P ovale 92·7% (86·7-96·6). The GF Panel had a negative percent agreement equal to or greater than 99·2% (98·6-99·6) for all analytes.This 1 h sample-to-answer, molecular device can detect common causative agents of acute febrile illness with excellent positive percent agreement and negative percent agreement directly in whole blood. The targets of the assay are prevalent in tropical and subtropical regions globally, and the assay could help to provide both public health surveillance and individual diagnoses.BioFire Defense, Joint Project Manager for Medical Countermeasure Systems and US Army Medical Materiel Development Activity, and National Institute of Allergy and Infectious Diseases.

Basal cell carcinoma is the most common neoplasm entity affecting the skin. The gold standard treatment is based on complete resection of the tumor, with disease-free edges. In lesions larger than 1.5 cm and in special areas, such as the back or tip of the nose, it is challenging to perform primary closure of the lesion, so advanced closure techniques are required, such as flaps or grafts. Below is the case of a 73-year-old patient who presents with a tumor of more than 1 year of evolution, for which an advancement and rotation nasolabial flap was used, obtaining disease-free margins, with adequate closure, obtaining quite acceptable functional and aesthetic results.

Culinary globalization in Indian cities has resulted in new patterns of food consumption and production. Aside from the increasing presence of global franchises such as Costa Coffee, McDonald’s and Kentucky Fried Chicken, local and foreign entrepreneurs have established restaurants that offer various national cuisines. In Delhi, for example, Japanese-themed restaurants cater to the city’s growing appetite for new culinary experiences. So far our knowledge of culinary globalization in Indian cities has focused on consumption: How emerging gastronomic patterns relate to identity formations. The production of cuisines as part of the city’s culinary globalization is rarely explored. In this paper, I focus on the role of Filipino ‘sushi chefs’ as cultural intermediaries who localize Japanese cuisine. This paper discusses their emergent practices of cultural mediation, namely adapting to local taste, peer mentoring and communicative labor. I argue that such practices of cultural mediation point to the social dynamics of cultural production.

The Baird’s tapir is the largest land mammal living in the Mexican Selva Maya, which is the largest tropical forest in America after the Amazon. Tapirs are herbivores that play a key role in maintaining the health of tropical forests by dispersing seeds in their feces (poop). Tapirs are mysterious, silent, and nocturnal characteristics that make them difficult to study. In our research, we analyzed the microbes in tapirs’ feces to understand the health of tapir populations in the Mexican Selva Maya. We found that a large amount of variety in tapirs’ fecal microbes is associated with a healthy tropical forest ecosystem. Maybe the analysis of the fecal microbes of wildlife can be used as a gentle technique to help us understand the health status of animals and the environments in which they live.

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Objetivos: Conocer el estado actual de la práctica de la neuropsicología en Ecuador a través de la administración de una encuesta online. Metodos: Un total de 48 profesionales que trabajan en el campo de la neuropsicología completaron una encuesta online entre agosto del 2018 hasta diciembre del 2019. Resultados: La mayoría de los participantes fueron mujeres (62.5%) y con una media de edad de 37.23. El 87.5% reporta haber recibido entrenamiento en neuropsicología en postgrado. La mayoría está empleada en práctica privada, universidades y/o clínicas, y reportan estar satisfechos con su trabajo. Los diagnósticos tratados con mayor frecuencia son el Trastorno por Déficit de Atención e Hiperactividad (TDAH), problemas de aprendizaje y trastornos de lenguaje. Las tres principales barreras identificadas para el desarrollo de la neuropsicología son la falta de programas de formación académica, la falta de programas de formación clínica y la falta de disposición para colaborar entre los profesionales. Conclusiones: La práctica de la neuropsicología en Ecuador está a la par con la de Latinoamérica. Sin embargo, ciertos cambios son necesarios como, incrementar los programas académicos y clínicos de entrenamiento en el área, formalizar regulaciones que garanticen calidad y estándares en la práctica, y continuar baremando y validando pruebas neuropsicológicas en el país.

This study reports a SiN x channel optical waveguide on a SiO2-covered bulk Si platform. The waveguide shows a low propagation loss of ∼0.6 dB/cm at 1550 and 1310 nm wavelengths. The SiN x film is deposited by reactive sputtering and is free from N–H species, which cause optical absorption loss at ∼1520 nm. No post-deposition high-temperature annealing is required as an increase in sputtering temperature, from room temperature to a moderate temperature of 200 °C, is effective for low-loss propagation. Based on chemical and optical analyses, the quality of the sputtered film at 200 °C is comparable to that prepared by low-pressure chemical vapor deposition at a high temperature of 820 °C. Fabricated fundamental passive optical devices (a multi-mode interferometer splitter and a directional coupler) reveal reasonable device function. A ring resonator shows a thermally stable operation because of the small thermo-optic coefficient for the SiN x , on the order of 10−5 K−1. The results indicate that the SiN x film by reactive sputtering at 200 °C can be favorably applied for photonic integration concerning CMOS back-end processing and hybrid-integration processing with non-CMOS materials. A Si-on-insulator wafer is not necessarily used as the platform, but a low-cost bulk Si wafer is replaced depending on the application. The reduction in the SiO2 under-cladding thickness, as thin as 1.0 µm, is examined regarding the potential in multilayered interconnects.

Shoulder computed tomography (CT) is commonly utilized in preoperative planning for total shoulder arthroplasty. Conventional-dose shoulder CT may expose patients to more ionizing radiation than is necessary to provide high-quality images for this procedure. The purpose of this study was to evaluate the utility of simulated low-dose CT images for preoperative planning using manual measurements and common preoperative planning software.Eighteen shoulder CT scans obtained for preoperative arthroplasty planning were used to generate CT images as if they had been acquired at reduced radiation dose (RD) levels of 75%, 50%, and 25% using a simulation technique that mimics decreased x-ray tube current. This technique was validated by quantitative comparison of simulated low-dose scans of a cadaver with actual low-dose scans. Glenoid version, glenoid inclination, and humeral head subluxation were measured using 2 commercially available software platforms and were also measured manually by 3 physicians. These measurements were then analyzed for agreement across RD levels for each patient. Tolerances of 5° of glenoid version, 5° of glenoid inclination, and 10% humeral head subluxation were used as equivalent for preoperative planning purposes.At all RD levels evaluated, the preoperative planning software successfully segmented the CT images. Semiautomated software measurement of 25% RD images was within tolerances in 99.1% of measurements; for 50% RD images, within tolerances in 96.3% of measurements; and for 75% RD images, within tolerances in 100% of measurements. Manual measurements of 25% RD images were within these tolerances in 95.1% of measurements; for 50% RD images, in 98.8% of measurements; and for 75% RD images, in 99.4% of measurements.Simulated low-dose CT images were sufficient for reliable measurement of glenoid version, glenoid inclination, and humeral head subluxation by preoperative planning software as well as by physician-observers. These findings suggest the potential for substantial reduction in RD in preoperative shoulder CT scans without compromising surgical planning.The adoption of low-dose techniques in preoperative shoulder CT may lower radiation exposure for patients undergoing shoulder arthroplasty, without compromising image quality.

Ante la problemática de la perdida de gran cantidad de micro, pequeñas y medianas empresas (Mipymes), por la emergencia sanitaria COVID-19 y la falta de conocimiento y recursos digitales, se presenta un documento que describe ocho herramientas tecnológicas, mostrando las ventajas que cada una de ellas proporciona a este grupo de empresas, se lleva a cabo un estudio exploratorio, a través de una revisión documental sobre el tema, la información obtenida acerca de las herramientas se encuentran estructuradas, en tres aspectos; para apoyar en el resguardo e intercambio de información; como aportación en la mejora de los procesos y en función de la atención a clientes; lo que permite a los responsables de la toma de decisiones, identificar con claridad las ventajas que le pueden ofrecer el conjunto de herramientas tecnológicas presentadas en el presente documento.

This study aimed to evaluate the predictive ability of NIRS for the estimation of the chemical composition and organic matter digestibility (OMD) of total mixed rations (TMR) for dairy cows. Moreover, herein, empirical equations based on chemical parameters were developed for calculating the OMD. Samples were collected from Galician dairy farms and were scanned in duplicate a Foss NIRSystem 6500 monochromator (1100-2500 nm). The predictive ability of NIRS models was evaluated according to the coefficient of determination in external validation ($r$2). High $r$2 (equal to or higher than 0.90) was shown in predicting chemical composition, however, the estimation of OMD was acceptable ($r$2 = 0.83). The ability of the NIRS models for estimating the chemical composition was considered excellent, with the ratio performance deviation of external validation ($RPD$) higher than 3.0, allowing for quantitative predictions. The estimation of the OMD value by NIRS was considered acceptable ($RPD$ = 2.5), and led to reduction in the standard error of external validation, in comparison of the best empirical model based on the chemical composition of samples (from ± 2.06% to ± 1.89%). Therefore, this study demonstrated that the NIRS is an effective technology for the rapid and precise nutritional evaluation of TMR in Galicia.

El jaguar, bestia majestuosa reverenciada por nuestros antepasados e icono de las selvas tropicales, es un animal con una historia fascinante. Los estudios científicos nos ayudan a develar los detalles de su épica travesía a través del tiempo y la geografía del continente americano.

PDF file - 507K, Koilocyte-like cells observed in an HPV negative verrucous papilloma (S1); H&E and pERK staining of gastric epithelium from mice treated for 60 days with 60 mg/kg Vemurafenib (S2); pERK staining of Vemurafenib and vehicle treated cSCC (S3); Reduced hyperkeratosis and improved grooming of K14-HPV16 mice treated with PD0325901 (S4); cSCC tumor response after treatment with 3 mg/kg PD0325901 (S5).

PDF file - 50K, RAS mutation and HPV status of cutaneous lesions by histological type.

Treatment with RAF inhibitors such as vemurafenib causes the development of cutaneous squamous cell carcinomas (cSCC) or keratoacanthomas as a side effect in 18% to 30% of patients. It is known that RAF inhibitors activate the mitogen—activated protein kinase (MAPK) pathway and stimulate growth of RAS-mutated cells, possibly accounting for up to 60% of cSCC or keratoacanthoma lesions with RAS mutations, but other contributing events are obscure. To identify such events, we evaluated tumors from patients treated with vemurafenib for the presence of human papilloma virus (HPV) DNA and identified 13% to be positive. Using a transgenic murine model of HPV-driven cSCC (K14-HPV16 mice), we conducted a functional test to determine whether administration of RAF inhibitors could promote cSCC in HPV-infected tissues. Vemurafenib treatment elevated MAPK markers and increased cSCC incidence from 22% to 70% in this model. Furthermore, 55% of the cSCCs arising in vemurafenib-treated mice exhibited a wild-type Ras genotype, consistent with the frequency observed in human patients. Our results argue that HPV cooperates with vemurafenib to promote tumorigenesis, in either the presence or absence of RAS mutations. Cancer Res; 74(8); 2238–45. ©2014 AACR.

In a global scenario of increasing the use of wood as a structure, the idea of making quality timber production compatible with other forestry activities, including resin extraction, has arisen. Implementing resin extraction practices can bring various socioeconomic benefits to forest communities during tree growing. However, the effects of resin extraction on wood quality are still unknown. Within this context, this research aimed to evaluate the quality of Pinus pinaster timber from resing trees. A total of 238 boards from resin-treated and control trees from two plots located in Galicia were evaluated. Non-destructive and bending tests were carried out according to European standards. The influence of the resin activity on the quality of wood was statistically analyzed. Statistically significant differences between samples of resin and control samples were analyzed for non-destructive, strength, modulus of elasticity, and density parameters. In general, it was observed that the resin activity did not affect the parameters analyzed.

IntroductionIn response to viral infection, neutrophils release inflammatory mediators as part of the innate immune response, contributing to pathogen clearance through virus internalization and killing. Pre- existing co-morbidities correlating to incidence to severe COVID-19 are associated with chronic airway neutrophilia. Furthermore, examination of COVID-19 explanted lung tissue revealed a series of epithelial pathologies associated with the infiltration and activation of neutrophils, indicating neutrophil activity in response to SARS-CoV-2 infection.MethodsTo determine the impact of neutrophil-epithelial interactions on the infectivity and inflammatory responses to SARS-CoV-2 infection, we developed a co-culture model of airway neutrophilia. This model was infected with live SARS-CoV-2 virus the epithelial response to infection was evaluated.ResultsSARS-CoV-2 infection of airway epithelium alone does not result in a notable pro-inflammatory response from the epithelium. The addition of neutrophils induces the release of proinflammatory cytokines and stimulates a significantly augmented proinflammatory response subsequent SARS-CoV-2 infection. The resulting inflammatory responses are polarized with differential release from the apical and basolateral side of the epithelium. Additionally, the integrity of the \epithelial barrier is impaired with notable epithelial damage and infection of basal stem cells.ConclusionsThis study reveals a key role for neutrophil-epithelial interactions in determining inflammation and infectivity.

Background Studies examining the association between in utero Zika virus (ZIKV) exposure and child neurodevelopmental outcomes have produced varied results limited by the absence of a comparison group. The present study aimed to assess the neurodevelopmental outcomes among a cohort of children born with normal head circumference from pregnant people enrolled in the Zika in Pregnancy in Honduras (ZIPH) cohort study between July and December 2016. Methods Enrollment of pregnant people was voluntary and occurred during their first prenatal visit at a health center in Tegucigalpa, with collection of venous blood. Children with the following characteristics were selected for the longitudinal follow-up study: normal birth head circumference, > 6 months of age, born at one of two hospitals in Tegucigalpa, and known in utero ZIKV exposure status. In utero exposure to ZIKV was defined as a positive prenatal ZIKV IgM and/or positive ZIKV RNA result at enrollment. The developmental evaluation included Spanish language versions of the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) and the Ages & Stages Questionnaires: Social-Emotional, Second Edition (ASQ:SE-2). Results One hundred fifty-two children were assessed between May 2018 and March 2020. The mean age was 2.0 years, and > 93% had adequate anthropometric growth. Sixty children were exposed to ZIKV during pregnancy. BSID-III and ASQ:SE-2 were performed in 151 and 152 children, respectively. Forty-one children had a delay (

Ocular chemical burns are produced by irritants, acids or alkalis. Their severity depends on the type of the causative chemical substance, its concentration, its physical form, the duration of contact, the ocular surface area affected and the delay in medical attention. Severe cases can be difficult to manage posing a challenge for general practitioners and ophthalmology specialists. This review aims to describe a protocol of action for their immediate management since they are ophthalmic emergencies which can lead to fatal ocular consequences without adequate medical treatment, impacting on the health, quality of life and labor productivity of the patient.

Sparse reconstruction is an important aspect of modern medical imaging, reducing the acquisition time of relatively slow modalities such as magnetic resonance imaging (MRI). Popular methods are based mostly on compressed sensing (CS), which relies on the random sampling of Fourier coefficients ($k$-space) to produce incoherent (noise-like) artefacts that can be removed via convex optimisation. Hardware constraints currently limit Cartesian CS to one dimensional (1D) phase-encode undersampling schemes, leading to coherent and structured artefacts. Reconstruction algorithms typically deploy an idealised and limited 2D regularisation for artefact removal, which increases the difficulty of image recovery. Recognising that phase-encode artefacts can be separated into contiguous 1D signals, we develop two decoupling techniques that enable explicit 1D regularisation. We thereby leverage the excellent incoherence characteristics in the phase-encode direction. We also derive a combined 1D + 2D reconstruction technique that further takes advantage of spatial relationships within the image, leading to an improvement of existing 2D deep-learned (DL) recovery techniques. Performance is evaluated on a brain and knee dataset. We find the proposed 1D CNN modules significantly improve PSNR and SSIM scores compared to the base 2D models, demonstrating a superior scaling of performance compared to increasing the size of 2D network layers.

We argue that there is a special doping point in the phase diagram of cuprates, such that the condensation of holes into a charge-ordered and into a superconducting phase are degenerate in energy but with an energy barrier in between. We present a Monte Carlo simulation of this problem without and with quenched disorder. While in the clean case charge order and superconductivity are separated by a first-order line which is nearly independent of temperature, in the presence of quenched disorder, charge order is fragmented into domains separated by superconducting filaments reminiscent of the supersolid behavior in $^4$He. The resulting phase diagram is in good agreement with the experiments., Comment: 32 pages, 18 figures, Submitted to SciPost Physics

In this work, we study the previously unexplored resonant region of neutrino self-interactions. Current disagreement on late and early time observations of the Universe expansion could be solved with new physics acting before the recombination era. Nonstandard neutrino self-interactions are among the most appealing candidates to solve this issue since they could be testable in the near (or middle) future. We use linear cosmological datasets to test neutrino self-interactions for a sample of fixed scalar mediator masses in the range $10^{-2}$ eV $\leq m_{\varphi}\leq 10^{2}$ eV. The resonant behavior produces observable effects at lower couplings than those reported in the literature for heavy and light mediators. We observe that in the best case scenario, using the Planck + BAO dataset, the tension with local measurements of $H_0$ eases from 4.9$\sigma$ (for $\Lambda$CDM) down to 2.8$\sigma$. The joint data set which includes Planck, BAO, and $H_0$ prefers a non-zero interaction with at least 2.3$\sigma$ significance in the range $0.5$ eV $\leq m_{\varphi}\leq 10$ eV. These results add the last piece in the parameter space of neutrino self-interactions at the linear perturbation regime.

We study numerically Anderson localization on lattices that are tree-like except for the presence of one loop of varying length $L$. The resulting expressions allow us to compute corrections to the Bethe lattice solution on i) Random-Regular-Graph (RRG) of finite size $N$ and ii) euclidean lattices in finite dimension. In the first case we show that the $1/N$ corrections to to the average values of observables such as the typical density of states and the inverse participation ratio have prefactors that diverge exponentially approaching the critical point, which explains the puzzling observation that the numerical simulations on finite RRGs deviate spectacularly from the expected asymptotic behavior. In the second case our results, combined with the $M$-layer expansion, predict that corrections destroy the exotic critical behavior of the Bethe lattice solution in any finite dimension, strengthening the suggestion that the upper critical dimension of Anderson localization is infinity. This approach opens the way to the computation of non-mean-field critical exponents by resumming the series of diverging diagrams through the same recipes of the field-theoretical perturbative expansion.

La tuberculosis en niños puede presentarse desde la forma más común, pulmonar, hasta formas extrapulmonares, que por ser paucibacilares, su confirmación bacteriológica puede ser un desafío. La pericarditis tuberculosa es rara, sin embargo, representa la primera causa de pericarditis en áreas de alta prevalencia de tuberculosis. Presentamos el caso de paciente de 5 meses de edad con pericarditis tuberculosa.

Introduction Osteonecrosis of the femoral head (ONFH) can occur after traumatic injuries of the hip. Surgical treatment with total hip arthroplasty (THA) may not produce lifelong viability in younger patients. Free vascularized fibular graft (FVFG) has become a reliable method to delay or even avoid THA in this patient population by aiming to correct loss of viable bone through vascularized autologous bone transfer. The purpose of this study was to evaluate the longevity and outcomes of FVFG for traumatic hip injuries resulting in ONFH. Methods We performed a retrospective review of our institutional database of patients who had undergone FVFG from 1980-2006 for post-traumatic ONFH and had a minimum follow-up of 5 years. Data collected included demographics, pre-operative Urbaniak ONFH staging, Harris Hip scores (HHS), SF-12 scores, and conversion to THA. Results Seventy-two hips in 68 patients met inclusion criteria. Mean follow-up was 11.6 years (range 5.1–33.2 years). Etiology included femoral neck fracture in 36 patients (61%), hip dislocation in 7 (12%), trauma without fracture or dislocation in 11 (19%), and femoral neck nonunion in 5 (8%). The most common stage at presentation was stage IV (48 patients). Graft survival at final follow-up (mean 10.9 years) was 64%, with mean time to conversion to THA of 8.4 years in those that did not survive (36%). There was no difference between THA conversion rates in hips with pre-collapse (Stage I and II) versus impending or post-collapse (Stage III or IV) lesions (p = 0.227). In hips with surviving grafts at final follow-up, mean HHS improved from 56.7 to 77.3 (SD 24.57, range 69–93), a mean improvement of 20.6 (p Conclusions Our study reveals improvement in HHS in surviving FVFG and an acceptable overall THA conversion rate at mid to long term follow-up in Urbaniak stage I through IV hips. FVFG remains a viable option for treatment in younger patients with pre- and post-collapse (stage IV) ONFH lesions secondary to hip trauma.