1. Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene
- Author
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Likun Liu, Lawrence Owusu, Cuili Zhang, Liye Zhou, Jian Kang, Xiaoqing Wang, Jing Wang, Lin Zhang, Weiling Li, Xiao Xu, and Guoqiang Jiang
- Subjects
0301 basic medicine ,Transcription, Genetic ,endocrine system diseases ,Carcinoma, Ovarian Epithelial ,migration ,Salvia miltiorrhiza ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Cell Movement ,dihydrotanshinone I ,Neoplasm Metastasis ,Zebrafish ,Ovarian Neoplasms ,Cell Death ,Chemistry ,Quinones ,female genital diseases and pregnancy complications ,Gene Expression Regulation, Neoplastic ,ovarian cancer ,030220 oncology & carcinogenesis ,Molecular Medicine ,Female ,Original Article ,Signal Transduction ,medicine.drug ,Class I Phosphatidylinositol 3-Kinases ,DNA damage ,proliferation ,03 medical and health sciences ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Neoplasm Invasiveness ,Furans ,PI3K/AKT/mTOR pathway ,Cell Proliferation ,Platinum ,Cisplatin ,Cell growth ,Gene Expression Profiling ,Original Articles ,PIK3CA ,Cell Biology ,Phenanthrenes ,medicine.disease ,In vitro ,Disease Models, Animal ,030104 developmental biology ,Drug Resistance, Neoplasm ,Cancer cell ,Cancer research ,Ovarian cancer ,Proto-Oncogene Proteins c-akt - Abstract
Dihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, the therapeutic benefits and underlying mechanisms of DHTS on ovarian cancer remain uncertain. In this study, we demonstrated the cytocidal effects of DHTS on chemosensitive ovarian cancer cells with or without platinum‐based chemotherapy. DHTS was able to inhibit proliferation and migration of ovarian cancer cells in vitro and in vivo through modulation of the PI3K/AKT signalling pathways. Combinatorial treatment of DHTS and cisplatin exhibited enhanced DNA damage in ovarian cancer cells. Overall, these findings suggest that DHTS induces ovarian cancer cells death via induction of DNA damage and inhibits ovarian cancer cell proliferation and migration.
- Published
- 2020