138 results on '"Kinga Polańska"'
Search Results
2. Urinary concentration of selected nonpersistent endocrine disrupting chemicals—reproductive outcomes among women from a fertility clinic
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Paweł Radwan, Bartosz Wielgomas, Michał Radwan, Rafał Krasiński, Stella Bujak-Pietrek, Kinga Polańska, Anna Kilanowicz, and Joanna Jurewicz
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Health, Toxicology and Mutagenesis ,Environmental Chemistry ,General Medicine ,Pollution - Abstract
Parabens and benzophenones are compounds widely used in cosmetics and personal care products. Although human exposure is widespread there is a limited number of epidemiological studies assessing the relationship between exposure to these chemicals and female reproductive health. The aim of the study is to explore the relationship between paraben and benzophenone concentrations and reproductive outcomes among women attending a fertility center. This prospective cohort included 450 women undergoing in vitro treatment (IVF) at fertility clinic in Poland. The validated gas chromatography ion-tap mass spectrometry to assess concentrations of parabens in urine (methyl (MP), ethyl (EP), propyl (PP), butyl paraben (BP)) and benzophenone-3 (BP-3) was used. To explore the relationship between concentrations of examined chemicals and reproductive outcomes (methaphase II (MII) oocyte yield, total oocyte yield, implantation rate, fertilization rate, clinical pregnancy, live births), multivariable generalized linear mixed model was used for the analysis. Increased exposure to butyl paraben was associated with a significant decrease in MII oocyte count (p = 0.007) when exposure to BP was treated as the continuous variable. Additionally, the exposure to BP in the highest quartile of exposure also decreases MII oocyte count (p = 0.02) compared to the lowest quartile. Urinary concentrations of BP were not related to total oocyte count, fertilization and implantation rate, clinical pregnancy, and live birth when the exposure variable was continuous variable or in the quartiles of exposure. Exposure to MP, EP, PP, the sum of examined parabens, and benzophenone-3 were not related to any of the examined reproductive outcomes. Exposure to butyl paraben was associated with a decrease in MII oocyte count among women attending fertility clinic rinsing concerns that exposure may have a potential adverse impact on embryological outcomes. The results emphasize the importance to reduce chemicals in the environment in order to minimize exposure. As this is the first study showing such an association, further research is needed to confirm these novel results in other populations. Graphical Abstract
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- 2023
3. Analiza wielokierunkowa czynników towarzyszących nadwadze i otyłości u dzieci i młodzieży – badanie przekrojowe
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Aneta Gwozdowska, Kinga Polańska, Ewa Starostecka, Krzysztof Zeman, Kamil Gwozdowski, Dorota Kaleta, and Leokadia Bąk-Romaniszyn
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General Earth and Planetary Sciences ,General Environmental Science - Published
- 2023
4. Correction: Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study
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Mercè Garí, Rebecca Moos, Daniel Bury, Monika Kasper-Sonnenberg, Agnieszka Jankowska, Aleksandra Andysz, Wojciech Hanke, Dennis Nowak, Stephan Bose-O’Reilly, Holger M. Koch, and Kinga Polańska
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Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health - Published
- 2023
5. REPRO_PL-Polish Mother and Child Cohort-Exposure, Health Status, and Neurobehavioral Assessments in Adolescents-Design and Cohort Update
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Magdalena Janc, Agnieszka Jankowska, Monika Weteska, Agnieszka Brzozowska, Wojciech Hanke, Joanna Jurewicz, Mercè Garí, Kinga Polańska, Joanna Jerzyńska, and Ministerio de Ciencia e Innovación (España)
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birth cohort ,pregnancy ,childhood ,adolescence ,environmental exposures ,health and neurodevelopment ,Adolescent ,Health and neurodevelopment ,Health, Toxicology and Mutagenesis ,Health Status ,Environmental exposures ,Public Health, Environmental and Occupational Health ,Mothers ,Environmental Exposure ,Childhood ,Adolescence ,Cohort Studies ,Child Development ,Pregnancy ,Maternal Exposure ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Humans ,Female ,Prospective Studies ,Poland ,Child ,Birth cohort - Abstract
Early life is a crucial window of opportunity to improve health across the life course. The prospective cohort study design is the most adequate to evaluate the longitudinal effects of exposure, the notification of changes in the exposure level and evaluation of the simultaneous impact of various exposures, as well as the assessment of several health effects and trajectories throughout childhood and adolescence. This paper provides an overview of the Polish Mother and Child cohort (REPRO_PL), with particular emphasis on Phase IV of this study. REPRO_PL is conducted in central Europe, where such longitudinal studies are less frequently implemented. In this population-based prospective cohort, which was established in 2007, three phases covering pregnancy (I), early childhood (II), and early school age (III) periods have already been completed. Phase IV gives a uniform opportunity to follow-up children during adolescence in order to evaluate if the consequences of prenatal and early postnatal exposures still persist at the age of 14. Moreover, we will be able to investigate the associations between simultaneous exposures to a broad spectrum of environmental factors, adolescents' health and neurobehavioral outcomes, and their trajectories within life, which is a novel framework of high scientific, public health and clinical priority., This study was supported by the grants from the National Science Centre (Nos. 2014/15/B/NZ7/00998, 2017/25/B/NZ5/02338, and 2021/41/B/NZ7/04341). MG acknowledges the support from the IDAEA-CSIC Severo Ochoa Excellence Programme through the Grant CEX 2018-000894-S funded by MCIN/AEI/10.039/501100011033.
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- 2022
6. Children's exposure to bisphenols, phthalates and non-phthalate plasticizers in Poland
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Mercè Garí, Holger Koch, Daniel Bury, Rebeca Moos, Claudia Pälmke, Wojciech Hanke, Agnieszka Jankowska, and Kinga Polańska
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General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
7. Cluster analysis of exhaled volatile organic compounds (VOCs)-link between environmental exposure and asthma in preschool children
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Monika Bobrowska‐Korzeniowska, Paweł Majak, Agnieszka Brzozowska, Kinga Polańska, Dorota Kaleta, Katarzyna Smejda, Ewa Mospinek, Włodzimierz Stelmach, and Joanna Jerzyńska
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Volatile Organic Compounds ,Breath Tests ,Exhalation ,Child, Preschool ,Immunology ,Immunology and Allergy ,Cluster Analysis ,Humans ,Environmental Exposure ,Asthma - Published
- 2022
8. Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children
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Matthew Suderman, Catherine M. Phillips, Fionnuala M. McAuliffe, James R. Hébert, Johan C. de Jongste, Caroline L Relton, Barbara Heude, Nicholas C. Harvey, Wojciech Hanke, Sara M. Mensink-Bout, John Mehegan, Kinga Polańska, Isabella Annesi-Maesano, Ling-Wei Chen, Adrien M. Aubert, Evelien R. van Meel, Liesbeth Duijts, Cecily Kelleher, Sarah Crozier, Cyrus Cooper, Jonathan Y. Bernard, Nitin Shivappa, Vincent W. V. Jaddoe, Joanna Jerzyńska, Pediatrics, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Singapore Institute for Clinical Sciences [Singapour] (SICS), Agency for science, technology and research [Singapore] (A*STAR), University College Dublin [Dublin] (UCD), University Hospital Southampton NHS Foundation Trust, University of Southampton, Nofer Institute of Occupational Medicine (NIOM), University of South Carolina [Columbia], Medical University of Łódź (MUL), University of Bristol [Bristol], and Salvy-Córdoba, Nathalie
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Pediatrics ,MESH: Asthma ,MESH: Respiratory Sounds ,Vital Capacity ,010501 environmental sciences ,01 natural sciences ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,0302 clinical medicine ,MESH: Pregnancy ,Pregnancy ,Forced Expiratory Volume ,030212 general & internal medicine ,2. Zero hunger ,medicine.diagnostic_test ,3. Good health ,Meta-analysis ,Child, Preschool ,Female ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,MESH: Forced Expiratory Volume ,03 medical and health sciences ,FEV1/FVC ratio ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Diet ,Dash ,medicine ,Humans ,SDG 2 - Zero Hunger ,0105 earth and related environmental sciences ,Asthma ,Respiratory Sounds ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Humans ,business.industry ,MESH: Child, Preschool ,MESH: Vital Capacity ,medicine.disease ,Confidence interval ,Diet ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Attributable risk ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,MESH: Female ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
RationaleSevere fetal malnutrition has been related to an increased risk of respiratory diseases later in life, but evidence for the association of a suboptimal diet during pregnancy with respiratory outcomes in childhood is conflicting. We aimed to examine whether a pro-inflammatory or low-quality maternal diet during pregnancy was associated with child's respiratory health.MethodsWe performed an individual participant meta-analysis among 18 326 mother–child pairs from seven European birth cohorts. Maternal pro-inflammatory and low-quality diets were estimated by energy-adjusted Dietary Inflammatory Index (E-DII) and Dietary Approaches to Stop Hypertension (DASH) scores. Preschool wheezing and school-age asthma were measured using questionnaires and lung function by spirometry.ResultsAfter adjustment for lifestyle and sociodemographic factors, we observed that a higher maternal E-DII score (a more pro-inflammatory diet) during pregnancy was associated only with a lower forced vital capacity (FVC) in children (z-score difference −0.05, 95% CI −0.08– −0.02, per interquartile range increase). No linear associations of the maternal E-DII or DASH score with child's wheezing or asthma were observed. In an exploratory examination of the extremes, a very low DASH score (ConclusionThe main results from this individual participant data meta-analysis do not support the hypothesis that maternal pro-inflammatory or low-quality diet in pregnancy are related to respiratory diseases in childhood.
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- 2022
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9. Inflammatory potential of diet and health outcomes in pregnancy, infancy, and childhood
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Catherine M. Phillips, Chloe Andrews, Emily Brigham, Ling-Wei Chen, Yueh-Ying Han, Corrine Hanson, Augusto Litonjua, Carmen Monthé-Drèze, Kinga Polańska, and Sarbattama Sen
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- 2022
10. Environmental exposure to persistent organic pollutants measured in breast milk of lactating women from an urban area in central Poland
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Kinga Polańska, Peter Gresner, Jolanta Gromadzinska, Marek Zieliński, Danuta Ligocka, and Wojciech Wąsowicz
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PCDFs ,PCDDs ,Breast milk ,Health, Toxicology and Mutagenesis ,010501 environmental sciences ,dl-PCBs ,01 natural sciences ,World health ,Persistent Organic Pollutants ,03 medical and health sciences ,0302 clinical medicine ,Animal science ,Animals ,Humans ,Lactation ,Environmental Chemistry ,Ecotoxicology ,POPs ,Benzofurans ,0105 earth and related environmental sciences ,Pollutant ,Milk, Human ,Chemistry ,food and beverages ,Environmental Exposure ,General Medicine ,Environmental exposure ,Dibenzofurans, Polychlorinated ,Polychlorinated Biphenyls ,030210 environmental & occupational health ,Pollution ,Toxicity ,%22">Fish ,Environmental Pollutants ,Female ,Poland ,Polychlorinated dibenzofurans ,Research Article - Abstract
Mothers’ milk is considered a channel by means of which new-borns are exposed to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (dl-PCBs), environmental pollutants entering food chain and accumulating in fat-rich tissues. In this study, the concentrations of selected PCDDs, PCDFs, and dl-PCBs (a total of 29 substances) in milk samples of 110 breast-feeding women from an urban area were analyzed using the high-resolution gas chromatography/high-resolution mass spectrometry method. Environmental exposure to these substances was expressed by means of the World Health Organization Toxicity Equivalent (WHO-TEQ2005) using the Toxicity Equivalent Factor values from van der Berg et al. (Toxicol. Sci. 93: 223-241, 2006). Concentrations and WHO-TEQ2005 values were then searched for plausible relationships with selected demographic and diet-related factors. The total WHO-TEQ2005 toxicity equivalent for all 29 substances was (mean ± SD) 10.57 ± 4.57 pg/g fat, while the WHO-TEQ2005 levels of PCDDs/PCDFs and dl-PCBs were 7.90 ± 4.17 pg/g fat and 2.67 ± 1.36 pg/g fat, respectively. The concentration and WHO-TEQ2005 toxicity equivalent of dl-PCBs correlated significantly with the mothers’ age (rP = 0.3814, p < 0.00005; rP = 0.2817, p < 0.005, respectively). The total WHO-TEQ2005 toxicity equivalent for all analyzed substances was found to be positively associated with the frequency of consumption of fish and dairy products (p < 0.05 for both associations). These outcomes must, however, be interpreted cautiously due to limited size of the study. The results of this paper may provide a basis for further studies on the exposure to PCDDs, PCDFs, and dl-PCBs, and mechanisms underlying their action.
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- 2020
11. Dog keeping at home before and during pregnancy decreased the risk of food allergy in 1-year-old children
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Kinga Polańska, Iwona Stelmach, Katarzyna Smejda, Włodzimierz Stelmach, and Paweł Majak
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allergic diseases ,Pediatrics ,medicine.medical_specialty ,Dermatology ,ANIMAL EXPOSURE ,Guinea pig ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,children ,pet ,Food allergy ,Immunology and Allergy ,Medicine ,Childbirth ,Internal medicine ,Original Paper ,Pregnancy ,business.industry ,Atopic dermatitis ,medicine.disease ,RC31-1245 ,RL1-803 ,Cohort ,ALLERGEN EXPOSURE ,business - Abstract
Introduction The relationship between allergen exposure to animals in pregnancy and the development of allergic symptoms is not clear. Aim To evaluate the association between prenatal and postnatal exposure to pet ownership and development of atopic dermatitis, food allergy and wheezing in children at the age of 1 and 2. Material and methods The mother-child pairs included in this study were part of the Polish Mother and Child Cohort. Mothers in each trimester of pregnancy and 1 year after childbirth have completed a questionnaire on animal exposure. Children's health status was assessed at around one year and two years of age. Results Keeping a dog at home before and during pregnancy (every trimester) decreased the risk of food allergy in the first year of life. On the other hand, keeping any animal other than a dog (cat, hamster, guinea pig, rabbit) before pregnancy and during each trimester separately increased the risk of food allergy in the first year of life of children. Keeping a guinea pig in the first trimester of pregnancy increased the risk of wheezing in the first year of life. The analysis did not show any significant associations between keeping animals at home before and during pregnancy and the occurrence of atopic dermatitis in the second year of life. Conclusions Keeping a dog at home before and during pregnancy decreased the risk of food allergy in 1-year-old children. This effect was eliminated in case of having a cat, hamster, guinea pig, or rabbit.
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- 2020
12. S-215 Working life, health and well-being of parents: a joint effort to uncover hidden treasures in birth cohorts
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Kinga Polańska, Kyriaki Papantoniou, Claudia Lissaker, Maribel Casas, Susan Peters, Jelena Sarac, Maria Albin, Cecilia Høst Ramlau-Hansen, Tina Garani-Papadatos, Raquel Lucas, Jenny Sela, Milena Maule, Ghislaine Scelo, Monica Ubalde-Lopez, and Ellen A. Nohr
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Gerontology ,Working life ,Well-being ,Joint (building) ,Psychology ,Birth cohort - Published
- 2021
13. The youth’s awareness of regulations banning e-cigarette advertising, promotion, sponsorship and their use in educational buildings
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Kinga Polańska and Dorota Kaleta
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Health (social science) ,Promotion (rank) ,Cigarette advertising ,media_common.quotation_subject ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Advertising ,Business ,media_common - Published
- 2021
14. Trends of e-cigarettes and tobacco use among secondary and high school students from Poland over three years observation
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Dorota Kaleta and Kinga Polańska
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Health (social science) ,Tobacco use ,Geography ,Environmental health ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) - Published
- 2021
15. Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study
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Kinga Polańska, Stephan Bose-O'Reilly, Rebecca K. Moos, Aleksandra Andysz, Monika Kasper-Sonnenberg, Agnieszka Jankowska, Daniel Bury, Mercè Garí, Wojciech Hanke, Holger M. Koch, and Dennis Nowak
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Male ,Health, Toxicology and Mutagenesis ,Emotions ,Neurodevelopment ,Urine ,Endocrine Disruptors ,Cohort Studies ,chemistry.chemical_compound ,Bisphenol A ,Pregnancy ,Surveys and Questionnaires ,Medicine ,Child ,Maternal-Fetal Exchange ,Children ,Psychomotor learning ,education.field_of_study ,Confounding ,Strengths and Difficulties Questionnaire ,Environmental Pollutants ,Female ,Public aspects of medicine ,RA1-1270 ,Birth cohort ,Biological Monitoring ,Cohort study ,Adult ,Population ,Mothers ,Phenols ,Environmental health ,Humans ,Benzhydryl Compounds ,education ,Life Style ,business.industry ,Research ,Body Weight ,Public Health, Environmental and Occupational Health ,Infant ,Daily Intake ,Industrial medicine. Industrial hygiene ,RC963-969 ,Social Class ,chemistry ,Neurodevelopmental Disorders ,Tobacco Smoke Pollution ,Poland ,Cotinine ,business ,Body mass index - Abstract
Background Bisphenol A (BPA) is an industrial chemical mostly used in the manufacture of plastics, resins and thermal paper. Several studies have reported adverse health effects with BPA exposures, namely metabolic disorders and altered neurodevelopment in children, among others. The aim of this study was to explore BPA exposure, its socio-demographic and life-style related determinants, and its association with neurodevelopmental outcomes in early school age children from Poland. Methods A total of 250 urine samples of 7 year-old children from the Polish Mother and Child Cohort Study (REPRO_PL) were analyzed for BPA concentrations using high performance liquid chromatography with online sample clean-up coupled to tandem mass spectrometry (online-SPE-LC-MS/MS). Socio-demographic and lifestyle-related data was collected by questionnaires or additional biomarker measurements. Emotional and behavioral symptoms in children were assessed using mother-reported Strengths and Difficulties Questionnaire (SDQ). Cognitive and psychomotor development was evaluated by Polish adaptation of the Intelligence and Development Scales (IDS) performed by trained psychologists. Results Urinary BPA concentrations and back-calculated daily intakes (medians of 1.8 μg/l and 46.3 ng/kg bw/day, respectively) were similar to other European studies. Urinary cotinine levels and body mass index, together with maternal educational level and socio-economic status, were the main determinants of BPA levels in Polish children. After adjusting for confounding factors, BPA has been found to be positively associated with emotional symptoms (β: 0.14, 95% CI: 0.022; 0.27). Cognitive and psychomotor development were not found to be related to BPA levels. Conclusions This study represents the first report of BPA levels and their determinants in school age children in Poland. The exposure level was found to be related to child emotional condition, which can have long-term consequences including social functioning and scholastic achievements. Further monitoring of this population in terms of overall chemical exposure is required.
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- 2021
16. Prenatal exposure to neurotoxic metals and micronutrients and neurodevelopmental outcomes in early school age children from Poland
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Anna Król, Kinga Polańska, Wojciech Hanke, Gemma Calamandrei, Anna Maria Tartaglione, Dorota Kaleta, Piotr Kaczmarek, Michał Krekora, Joanna Jerzyńska, Mercè Garí, Beata Janasik, Mariusz Grzesiak, Agnieszka Jankowska, and Renata Kuraś
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Psychomotor learning ,Pregnancy ,Schools ,Offspring ,business.industry ,Strengths and Difficulties Questionnaire ,Mercury ,medicine.disease ,Micronutrient ,Biochemistry ,Environmental health ,Cord blood ,Prenatal Exposure Delayed Effects ,Cohort ,medicine ,Humans ,Female ,Micronutrients ,Poland ,business ,Prenatal exposure ,General Environmental Science - Abstract
Exposure to environmental factors, such as neurotoxic metals and micronutrients, during critical periods of development can contribute to long-term consequences in offspring's health, including neurodevelopmental outcomes. The aim of this study was to evaluate the association between simultaneous prenatal exposure to metals [lead (Pb), cadmium (Cd), mercury (Hg)] and micronutrients [selenium (Se), zinc (Zn), copper (Cu)] and neurodevelopmental outcomes in school-age children from the Polish Mother and Child Cohort (REPRO_PL). Metals and micronutrients concentrations were measured in cord blood (Pb, Cd, Se, Zn, Cu) and in maternal hair (Hg) collected during the 3rd trimester of pregnancy. Behavioral and emotional problems, as well as children's cognitive and psychomotor development, were assessed in 436 school-age children using the Strengths and Difficulties Questionnaire (SDQ, filled in by the mothers) and the Polish adaptation of the Intelligence and Development Scales (IDS, administered by trained psychologists). Multivariate regression models were applied after imputation of missing values, using two approaches: (i) a joint analysis taking into account all metals and micronutrients simultaneously, and (ii) an ExWAS study (single-exposure model). In the SDQ, Hyperactivity/Inattention problems and Total difficulties were associated with higher Hg concentrations in maternal hair (0.18, 95% CI: 0.05; 0.3; and 0.14, 95% CI: 0.01; 0.3, respectively), whereas Emotional symptoms were inversely associated with Se and Zn levels in cord blood (−0.13, 95% CI: −0.3; 0.004; and −0.10, 95% CI: −0.2; 0.02, respectively). In the IDS, cord blood Pb levels were found to be negatively associated with Fluid and Crystallized IQ (−0.12, 95% CI: −0.3; 0.02; and −0.14, 95% CI: −0.3; 0.007, respectively) as well as Mathematical skills (−0.15, 95% CI: −0.3; 0.01). The current research has been able to simultaneously assess the exposure to various interacting chemicals during the prenatal period. We demonstrate that prenatal co-exposures to Pb, Hg, Zn and Se have long-term influences on the neuropsychological outcome of school-age children.
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- 2021
17. Maternal diet during pregnancy and risk of allergic diseases in children up to 7–9 years old from Polish Mother and Child Cohort study
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Agnieszka Brzozowska, Daniela Podlecka, Agnieszka Jankowska, Anna Król, Dorota Kaleta, Elżbieta Trafalska, Ewa Nowakowska-Świrta, Paweł Kałużny, Wojciech Hanke, Katarzyna Bal-Gierańczyk, Małgorzata Kowalska, Kinga Polańska, and Joanna Jerzyńska
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Cohort Studies ,Pregnancy ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Humans ,Mothers ,Female ,Poland ,Child ,Rhinitis, Allergic ,Biochemistry ,Diet ,General Environmental Science - Abstract
The impact of maternal diet during pregnancy on the risk of allergic diseases in childhood is an increasing scientific and public health concern. We evaluated the associations of maternal type of diet and essential elements and vitamins intake during pregnancy with offspring allergic and respiratory outcomes.The study population included 557 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL). Based on the Food Frequency Questionnaire filled in between the 20th-24th week of pregnancy, overall maternal diet was evaluated as the difference between the Prudent Dietary Pattern (PDP) score and Western Dietary Pattern (WDP) score ((PDP-WDP) score) and maternal achievement of dietary recommendations (estimated average requirement, EAR) for essential elements and vitamins was assessed. Children's health examination at age of 1, 2, and 7-9 years covered the following symptoms: infections, wheezing/asthma, food allergy, allergic rhinitis, and atopic dermatitis. At age of 7-9 years, children underwent spirometry and skin-prick tests.Children of the mothers who were not achieving adequate intake of vitamin C during pregnancy had a higher risk of wheezing and having more than two infections within the first two years of life comparing to those who met EAR (OR = 2.6, p = 0.05, and OR = 2.3, p = 0.04, respectively). Inadequate intake of vitamin E during pregnancy was related to a higher risk of atopic dermatitis (OR = 2.7, p = 0.04), whereas inadequate intake of magnesium during pregnancy was associated with the risk of wheezing in the offspring at age of two years (OR = 3.7, p = 0.03). A lower (PDP-WDP) score during pregnancy (indicating unhealthier diet) was associated with a higher risk of infections (OR = 1.5, p = 0.007) but a lower risk of atopic dermatitis (OR = 0.7, p = 0.02) at age of 7-9 years.These results may contribute to the body of evidence for the impact of maternal diet during pregnancy for children's optimal health, however further studies are needed before drawing conclusions and recommendations for clinical practice.
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- 2022
18. The effect of air pollution on the respiratory system in preschool children with contribution of urban heat islands and geographic data - the aim of the study and methodological assumptions
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Joanna Jerzyńska, Włodzimierz Stelmach, Kinga Polańska, Monika Bobrowska-Korzeniowska, Dorota Kaleta, Agata Kunert, and Iwona Stelmach
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Hot Temperature ,pm ,voc ,State of health ,Population ,Respiratory System ,Air pollution ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,children ,Environmental health ,Air Pollution ,medicine ,Humans ,Urban heat island ,Cities ,education ,Asthma ,Indoor air pollutants ,education.field_of_study ,Air Pollutants ,Public Health, Environmental and Occupational Health ,General Medicine ,allergy ,medicine.disease ,030210 environmental & occupational health ,Geography ,Air Pollution, Indoor ,Child, Preschool ,Medicine ,Particulate Matter ,Rural area ,Urban environment ,Environmental Monitoring - Abstract
It has been proven that outdoor and indoor air pollutants can cause adverse health effects and are able to promote the onset of atopic diseases. The current manuscript is focused on methodological issues. The aim of the study is to determine the effect of air pollution, urban environment, and urban heat islands (UHIs) on the occurrence of respiratory diseases including allergic rhinitis, asthma and wheezing in preschool children. The study group consists of 276 five-year-old children attending randomly selected kindergartens in the urban and rural areas of the Łódź Voivodeship. The questionnaire including data on the child’s state of health and socio-economic data will be filled by the caregivers. The children will undergo skin prick testing and the measurement of volatile organic compounds in exhaled breath. The key components of air pollution – particulate matter (PM) will be measured by personal meters. The PM sampling planned in the study will take 12 h for PM 2.5 and for PM 10 alike. Data on the level of outdoor air pollution will be collected based on the results obtained from air monitoring stations. The impact of air pollution, UHIs and the environment on the respiratory system and the presence of allergies in children, including chronic respiratory diseases, will be assessed. The project results will provide a scientific basis for the development of preventive programs in the population of children in the Łódź Voivodeship, adapted to the real health needs of society. Int J Occup Med Environ Health. 2021;34(4):453–60
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- 2021
19. Susceptibility to smoking and associated factors among the youth in central and eastern European countries
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Dorota Kaleta, Kinga Polańska, and Małgorzata Znyk
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Eastern european ,Geography ,Socioeconomics - Abstract
Background Tobacco use among young people still remains a major public health problem. The aim of this study was to examine the association between a variety of factors and susceptibility to smoking initiation and experimentation among the youth from central and eastern European countries. Methods The data used in the current analysis, focusing on current non-smokers, is available from the Global Youth Tobacco Survey, which was performed in five countries (the Czech Republic (2016), n = 3191; Slovakia (2016), n = 3178; Slovenia (2017), n = 2255; Romania (2017), n = 4681; Lithuania (2018), n = 2260). Results Among the never smokers, nearly a quarter of the students were susceptible to smoking in 4 of 5 countries (16% of those susceptible to smoking were identified in Romania). Moreover, 60% of the students in the Czech Republic, Slovakia and Slovenia, and about 50% of the students in Lithuania and Romania were found to be vulnerable to smoking experimentation (an analysis among ever smokers). The multiple regression models provided results that are consistent among all the examined countries, with the following factors identified as significant correlates of smoking initiation and experimentation: being girls, having more money available for own expenses, experiencing exposure to passive smoking in public places, as well as indicating peer smoking. Moreover, adolescents who have declared lack of antismoking education and knowledge on harmful effects of passive smoking, those who saw people using tobacco on TV, in videos or in movies as well as advertising of tobacco products at point of sales were susceptible to smoking. Finally, the students who shared an opinion that smoking helped people feel more comfortable at celebrations, parties or in other social gatherings were at higher risk of smoking susceptibility. Conclusions A high proportion of the youth from central and eastern European countries is susceptible to smoking. Personal and social factors and those related to educational and policy issues were strongly and consistently correlated with smoking susceptibility. These factors should be considered when designing and implementing anti-smoking activities among young people.
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- 2021
20. Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium
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Fionnuala M. McAuliffe, Barbara Heude, James R. Hébert, Caroline L Relton, Cecily Kelleher, John Mehegan, Sarah Crozier, Nicholas C. Harvey, Matthew Suderman, Ling-Wei Chen, Adrien M. Aubert, Wojciech Hanke, Jonathan Y. Bernard, Liesbeth Duijts, Kinga Polańska, Catherine M. Phillips, Aisling A. Geraghty, Elżbieta Trafalska, Nitin Shivappa, Sara M. Mensink-Bout, Charles Cooper, and Pediatrics
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Male ,Physiology ,Epidemiology ,Maternal Health ,Fetal Development ,Labor and Delivery ,0302 clinical medicine ,Pregnancy ,Medicine and Health Sciences ,Medicine ,Birth Weight ,030212 general & internal medicine ,Immune Response ,2. Zero hunger ,Fetal Growth Retardation ,Obstetrics ,Pregnancy Outcome ,Gestational age ,Obstetrics and Gynecology ,General Medicine ,3. Good health ,Europe ,Physiological Parameters ,Cohort ,Infant, Small for Gestational Age ,Generation R ,Female ,medicine.symptom ,Cohort study ,Research Article ,medicine.medical_specialty ,Birth weight ,Immunology ,030209 endocrinology & metabolism ,03 medical and health sciences ,Signs and Symptoms ,Sex Factors ,Humans ,Nutrition ,Inflammation ,business.industry ,Body Weight ,Infant, Newborn ,Biology and Life Sciences ,Maternal Nutritional Physiological Phenomena ,medicine.disease ,Diet ,Low birth weight ,Food ,Medical Risk Factors ,Birth ,Women's Health ,Clinical Medicine ,business ,Body mass index - Abstract
Background Adverse birth outcomes are major causes of morbidity and mortality during childhood and associate with a higher risk of noncommunicable diseases in adult life. Maternal periconception and antenatal nutrition, mostly focusing on single nutrients or foods, has been shown to influence infant birth outcomes. However, evidence on whole diet that considers complex nutrient and food interaction is rare and conflicting. We aim to elucidate the influence of whole-diet maternal dietary inflammatory potential and quality during periconceptional and antenatal periods on birth outcomes. Methods and findings We harmonized and pooled individual participant data (IPD) from up to 24,861 mother–child pairs in 7 European mother–offspring cohorts [cohort name, country (recruitment dates): ALSPAC, UK (1 April 1991 to 31 December 1992); EDEN, France (27 January 2003 to 6 March 2006); Generation R, the Netherlands (1 April 2002 to 31 January 2006); Lifeways, Ireland (2 October 2001 to 4 April 2003); REPRO_PL, Poland (18 September 2007 to 16 December 2011); ROLO, Ireland (1 January 2007 to 1 January 2011); SWS, United Kingdom (6 April 1998 to 17 December 2002)]. Maternal diets were assessed preconceptionally (n = 2 cohorts) and antenatally (n = 7 cohorts). Maternal dietary inflammatory potential and quality were ranked using the energy-adjusted Dietary Inflammatory Index (E-DII) and Dietary Approaches to Stop Hypertension (DASH) index, respectively. Primary outcomes were birth weight and gestational age at birth. Adverse birth outcomes, i.e., low birth weight (LBW), macrosomia, small-for-gestational-age (SGA), large-for-gestational-age (LGA), preterm and postterm births were defined according to standard clinical cutoffs. Associations of maternal E-DII and DASH scores with infant birth outcomes were assessed using cohort-specific multivariable regression analyses (adjusted for confounders including maternal education, ethnicity, prepregnancy body mass index (BMI), maternal height, parity, cigarettes smoking, and alcohol consumption), with subsequent random-effects meta-analyses. Overall, the study mothers had a mean ± SD age of 29.5 ± 4.9 y at delivery and a mean BMI of 23.3 ± 4.2 kg/m2. Higher pregnancy DASH score (higher dietary quality) was associated with higher birth weight [β(95% CI) = 18.5(5.7, 31.3) g per 1-SD higher DASH score; P value = 0.005] and head circumference [0.03(0.01, 0.06) cm; P value = 0.004], longer birth length [0.05(0.01, 0.10) cm; P value = 0.010], and lower risk of delivering LBW [odds ratio (OR) (95% CI) = 0.89(0.82, 0.95); P value = 0.001] and SGA [0.87(0.82, 0.94); P value < 0.001] infants. Higher maternal prepregnancy E-DII score (more pro-inflammatory diet) was associated with lower birth weight [β(95% CI) = −18.7(−34.8, −2.6) g per 1-SD higher E-DII score; P value = 0.023] and shorter birth length [−0.07(−0.14, −0.01) cm; P value = 0.031], whereas higher pregnancy E-DII score was associated with a shorter birth length [−0.06(−0.10, −0.01) cm; P value = 0.026] and higher risk of SGA [OR(95% CI) = 1.18(1.11, 1.26); P value < 0.001]. In male, but not female, infants higher maternal prepregnancy E-DII was associated with lower birth weight and head circumference, shorter birth length, and higher risk of SGA (P-for-sex-interaction = 0.029, 0.059, 0.104, and 0.075, respectively). No consistent associations were observed for maternal E-DII and DASH scores with gestational age, preterm and postterm birth, or macrosomia and LGA. Limitations of this study were that self-reported dietary data might have increased nondifferential measurement error and that causality cannot be claimed definitely with observational design. Conclusions In this cohort study, we observed that maternal diet that is of low quality and high inflammatory potential is associated with lower offspring birth size and higher risk of offspring being born SGA in this multicenter meta-analysis using harmonized IPD. Improving overall maternal dietary pattern based on predefined criteria may optimize fetal growth and avert substantial healthcare burden associated with adverse birth outcomes., In this cohort analysis, Ling-Wei Chen and colleagues explore associations of maternal dietary patterns with offspring birth outcomes., Author summary Why was this study done? Adverse birth outcomes are associated with higher morbidity and mortality during childhood and a higher risk of noncommunicable diseases in adult life. The Developmental Origins of Health and Diseases (DOHaD) theory posits that maternal periconceptional and intrauterine nutrition can alter the health trajectory of the offspring. Although individual maternal dietary factors have been studied widely, evidence on the impact of whole-diet maternal dietary inflammatory potential and quality on birth outcomes is scarce and conflicting. What did the researchers do and find? We investigated whether maternal prepregnancy and antenatal dietary quality and inflammatory potential are associated with birth outcomes in a consortium of 7 European cohorts in 5 countries using harmonized individual participant data from up to 24,861 mother–child pairs. After adjusting for confounders, we found that a low-quality and pro-inflammatory maternal diet during pregnancy is significantly associated with lower offspring birth weight and higher risk of offspring being born small-for-gestational-age (SGA). In male, but not female, infants higher maternal prepregnancy energy-adjusted Dietary Inflammatory Index (E-DII) score was associated with lower birth weight and head circumference, shorter birth length, and higher risk of SGA. What do these findings mean? Improving overall maternal dietary quality and reducing dietary inflammatory potential may optimize fetal growth and avert substantial healthcare burden associated with adverse birth outcomes. Policies to ensure availability of affordable healthy foods and programmatic efforts to inform and support women of reproductive age, such as raising awareness of the importance of maternal diet and prenatal and antenatal counseling would help women achieve a healthier diet.
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- 2021
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21. Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohorts
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Kinga Polańska, Barbara Heude, Hanan El Marroun, Wojciech Hanke, Giulia Mancano, Elżbieta Trafalska, Nitin Shivappa, Sara M. Mensink-Bout, Caroline L Relton, Raquel Garcia-Esteban, Adrien M. Aubert, Mònica Guxens, Maribel Casas, Liesbeth Duijts, Jonathan Y. Bernard, Agnieszka Jankowska, Ewelina Wesołowska, Paweł Kałużny, James R. Hébert, Matthew Suderman, Catherine M. Phillips, Pediatrics, Child and Adolescent Psychiatry / Psychology, and Clinical Psychology
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0301 basic medicine ,Dietary approaches to stop hypertension ,medicine.medical_specialty ,Offspring ,Emotions ,Mothers ,Behavioral Symptoms ,Anxiety ,Lower risk ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Pregnancy ,Internal medicine ,Inflammatory Index ,Dash ,medicine ,energy-adjusted Dietary ,Humans ,Aggressive behavior symptoms ,aggressive behavior symptoms ,Attention-Deficit/Hyperactivity Disorder symptoms ,Child ,Biological Psychiatry ,Depression (differential diagnoses) ,2. Zero hunger ,business.industry ,depressive and anxiety symptoms ,Odds ratio ,medicine.disease ,Attention-deficit/hyperactivity disorder symptoms ,Diet ,3. Good health ,030104 developmental biology ,Energy-adjusted Dietary Inflammatory Index ,Attention Deficit Disorder with Hyperactivity ,Meta-analysis ,Female ,pregnancy ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Depressive and anxiety symptoms ,Dietary Approaches to Stop Hypertension - Abstract
Background: The impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated the associations of dietary quality based on the Dietary Approaches to Stop Hypertension (DASH) score and dietary inflammatory potential based on the energy-adjusted Dietary Inflammatory Index (E-DII) score during pregnancy with emotional and behavioral symptoms of offspring at 7 to 10 years of age. Methods: Individual participant data for 11,870 mother-child pairs from four European cohorts participating in the ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression and anxiety, aggressive behavior, and attention-deficit/hyperactivity disorder in children were assessed using mother-reported tests and classified within the normal or borderline/clinical ranges using validated cutoffs. Adjusted odds ratios were determined by multivariable logistic regression models and aggregated by the two-level individual participant data meta-analysis method. Results: Higher maternal DASH scores (indicating better dietary quality) were associated with lower risk of depressive and anxiety symptoms, aggressive behavior symptoms, and attention-deficit/hyperactivity disorder symptoms within the borderline/clinical ranges: odds ratio [OR] 0.97, 95% confidence interval [CI], 0.95-0.99; OR 0.97, 95% CI, 0.94-0.99; OR 0.97, 95% CI, 0.95-0.98, per one-unit DASH score increase, respectively. For depression and anxiety, aggressive behavior, and attention-deficit/hyperactivity disorder symptoms, a one-unit increase in E-DII scores (a more proinflammatory diet) was associated with a 7% increased risk of all three analyzed emotional and behavioral symptoms: OR 1.07, 95% CI, 1.03-1.11; OR 1.07, 95% CI, 1.02-1.13; OR 1.07, 95% CI, 1.01-1.13, respectively. Conclusions: Our findings suggest that a maternal low-quality and proinflammatory diet may increase the risk of emotional and behavioral symptoms in children. This work was supported by an award from the European Union’s Horizon 2020 research and innovation programme under the ERA-Net Cofund of the Joint Programming Initiative Healthy Diet for Healthy Life (JPI-HDHL) (http://www.healthydietforhealthylife.eu) action number 696295 (Biomarkers for Nutrition and Health). Cofunding was provided by Science Foundation Ireland, Ireland (Grant No. SFI/16/ERA-HDHL/3360 [to CMP]), the UK Biotechnology and Biological Sciences Research Council (ERA-HDHL Biomarkers: BBSRC BB/P028187/1 [to CR]), the Polish National Centre for Research and Development (ERA-HDHL/01/ALPHABET/1/2017 [to KP]), the ZonMw The Netherlands (Grant No. 529051014; 2017) ALPHABET project (Grant No. 696295; 2017 [to LD]) and the French National Agency of Research (reference AnrR16227KK [to BH]). ALSPAC: This work was supported by the UK Medical Research Council and Wellcome (Grant No. 102215/2/13/2) and the University of Bristol. This publication is the work of the authors and Matthew Suderman will serve as guarantors for the contents of this paper. EDEN: This work was supported by the Foundation for Medical Research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR Cohorte Santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (FP7/2007-2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale, a complementary health insurance (MGEN), French National Agency for Food Security, French-speaking Association for the Study of Diabetes and Metabolism (ALFEDIAM). Generation R: This work was supported by the Erasmus Medical Centre, Rotterdam, the Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. Dr Liesbeth Duijts received funding from the European Union's Horizon 2020 cofunded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) (ALPHABET project (Grant No. 696295; 2017), ZonMW The Netherlands (Grant No. 529051014; 2017). Dr. Hanan El Marroun was supported by Stichting Volksbond Rotterdam, the Dutch Brain Foundation (De Hersenstichting, project number GH2016.2.01), and NARSAD Young Investigator Grant No. 27853 from the Brain & Behavior Research Foundation. The project received funding from the European Union’s Horizon 2020 Research and Innovation Programme (LIFECYCLE project, Grant No. 733206; 2016). REPRO_PL: This work was supported by the Ministry of Science and Higher Education, Poland (PBZ-MEiN-/8/2//2006; Contract No. K140/P01/2007/1.3.1.1); by the grant PNRF-218-AI-1/07 from Norway through the Norwegian Financial Mechanism within the Polish-Norwegian Research Fund, National Science Centre under the call of JPI HDHL Nutrition and Cognitive Function (2015/17/Z/NZ7/04273), and the National Science Centre, Poland (DEC-2014/15/B/NZ7/00998). Mònica Guxens (CPII18/00018) and Maribel Casas (CP16/00128) are funded by a Miguel Servet fellowship (from the Spanish Institute of Health Carlos III). We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme.
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- 2021
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22. Neurodevelopmental exposome: The effect of in utero co-exposure to heavy metals and phthalates on child neurodevelopment
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W. Hanke, Spyros Karakitsios, Denis Sarigiannis, Nafsika Papaioannou, C. Gabriel, Athanasios Salifoglou, Kinga Polańska, Evangelos Handakas, and Ourania Anesti
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Exposome ,GPX1 ,GPX3 ,Pathway analysis ,Mothers ,Physiology ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,Bayley Scales of Infant Development ,Cohort Studies ,03 medical and health sciences ,Child Development ,0302 clinical medicine ,Metabolomics ,Pregnancy ,Metals, Heavy ,Humans ,Medicine ,030212 general & internal medicine ,0105 earth and related environmental sciences ,General Environmental Science ,EWAS ,Environmental disease ,business.industry ,Child neurodevelopment ,Infant ,Environmental Exposure ,medicine.disease ,Neurodevelopmental Disorders ,In utero ,Prenatal Exposure Delayed Effects ,Female ,business - Abstract
In this study, the exposome paradigm has been applied on a mother-child cohort adopting an optimised untargeted metabolomics approach for human urine followed by advanced bioinformatics analysis. Exposome-wide association algorithms were used to draw links between in utero co-exposure to metals and phthalates, metabolic pathways deregulation, and clinically observed phenotypes of neurodevelopmental disorders such as problems in linguistic, motor development and cognitive capacity. Children (n = 148) were tested at the first and second year of their life using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Their mothers had been exposed to metals and phthalates during the pregnancy, according to human biomonitoring results from previously performed studies. Untargeted metabolomics analysis of biobanked urine samples from the mothers was performed using a combination of the high throughput analytical methods liquid chromatography-high resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonance (NMR). Most perturbed metabolic pathways from co-exposure heavy metals and phthalates were pathways related to the tricarboxylic acid cycle (TCA cycle) and oxidative phosphorylation, indicating the possibility of disruption of mitochondrial respiration. Overproduction of reactive oxygen species (ROS); the presence of glutathione peroxidase 3 (GPx3) during pregnancy and presence of glutathione peroxidase 1 (GPx1) in the umbilical cord were linked to verbal development problems. Another finding of the study is that in real life, adverse outcomes occur as a combination of environmental and social factors, all of them acting synergistically towards the deployment of an observed phenotype. Finally, the two-steps association process (exposure to pathways and pathways to adverse outcomes) was able to (a) provide associations that are not evident by directly associating exposure to outcomes and (b) provides additional insides on the mechanisms of environmental disease.
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- 2021
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23. Tobacco and E-Cigarettes Point of Sale Advertising-Assessing Compliance with Tobacco Advertising, Promotion and Sponsorship Bans in Poland
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Kinga Polańska and Dorota Kaleta
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medicine.medical_specialty ,Point of sale ,Health, Toxicology and Mutagenesis ,media_common.quotation_subject ,lcsh:Medicine ,Tobacco Industry ,Electronic Nicotine Delivery Systems ,computer.software_genre ,Tobacco industry ,point of sale advertising ,compliance ,Article ,Compliance (psychology) ,03 medical and health sciences ,0302 clinical medicine ,Promotion (rank) ,Advertising ,Tobacco ,medicine ,030212 general & internal medicine ,Enforcement ,media_common ,Marketing ,030505 public health ,Public health ,lcsh:R ,Tobacco control ,public health ,Public Health, Environmental and Occupational Health ,Commerce ,e-cigarettes ,Tobacco Products ,Checklist ,tobacco control ,Business ,Poland ,0305 other medical science ,computer - Abstract
The objective of this study was to evaluate compliance with the ban on tobacco and e-cigarette products advertising at point of sale (POS) before and after amendment of the Polish Tobacco Control Act. Data were collected, using an observation checklist, between March and October 2014 (n = 1450 POS) and between March and October 2019 (n = 1320 POS). Ban on tobacco and e-cigarette advertising at POS is commonly violated in Poland. In all POS, at least one form (including tobacco products display) of tobacco advertising was found in 2014 and in 2019. The most common types of tobacco advertising in 2014 were change and counter mats (61%, 42%), posters (38%) and illuminated banners (37%). In 2019, a decrease in promoting tobacco products in the form of mats (p ≤ 0.001), posters and boards (p <, 0.001) but an increase in video screens were observed (from 8% in 2014 to 30% in 2019, p <, 0.001). A significant increase in the presence of any e-cigarette ads, including e-cigarette displays, illuminated banners and video screens, was observed in 2019 as compared to 2014 (90% vs. 30%, 89% vs. 20%, 31% vs. 2%, 31% vs. 0.5%, 0.001). The minimum age or a no-sale-to-minors signs for tobacco and e-cigarettes were not sufficiently placed in POS to comply with the Act. Poor enforcement of the ban on tobacco and e-cigarette ads at POS provides the tobacco industry with an opportunity to promote their products using unlawful ways. There is a need to educate the public, retailers and civil society with respect to their legal responsibilities and roles.
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- 2020
24. Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral problems in childhood: an individual participant data meta-analysis of four European cohorts
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Giulia Mancano, James R. Hébert, Ewelina Wesołowska, Liesbeth Duijts, Caroline L Relton, Wojciech Hanke, M. Guxens, Elżbieta Trafalska, Jonathan Y. Bernard, M. Casas, Adrien M. Aubert, Agnieszka Jankowska, S.M. Mensink-Bout, R. Garcia-Esteban, Kinga Polańska, Barbara Heude, Nitin Shivappa, Hanan El Marroun, Matthew Suderman, Catherine M. Phillips, and Paweł Kałużny
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Pregnancy ,Diet quality ,Offspring ,business.industry ,Individual participant data ,Meta-analysis ,medicine ,General Earth and Planetary Sciences ,medicine.disease ,business ,General Environmental Science ,Clinical psychology - Published
- 2020
25. Pro-inflammatory and low quality maternal diet in pregnancy and the risk of childhood lower lung function and asthma: a meta-analysis of 18,000 children
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Kinga Polańska, Rosalie Mensink-Bout, Barbara Heude, Wojciech Hanke, Catherine M. Phillips, Nicholas C. Harvey, John Mehegan, James R. Hébert, Joanna Jerzyńska, Fionnuala M. McAuliffe, Matthew Suderman, Evelien R. van Meel, Nitin Shivappa, Johan C. de Jongste, Cecily Kelleher, Ling-Wei Chen, Sarah Crozier, Vincent W. V. Jaddoe, Isabella Annesi-Maesano, Cyrus Cooper, Jonathan Y. Bernard, Adrien M. Aubert, Liesbeth Duijts, and Caroline L Relton
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Spirometry ,Pregnancy ,Percentile ,Pediatrics ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Meta-analysis ,Cohort ,Dash ,Medicine ,business ,Adverse effect ,Asthma - Abstract
Background: Fetal exposure to a suboptimal maternal diet might affect respiratory health later in life. We tested the hypothesis that a pro-inflammatory or low-quality maternal diet in pregnancy was associated with child’s respiratory health. Methods: We performed an individual participant meta-analysis among 18,326 children and their mothers, participating in seven European birth cohorts. Maternal pro-inflammatory diet during pregnancy was estimated by the energy-adjusted Dietary Inflammatory Index score (E-DIITM), and low quality diet by the Dietary Approaches to Stop Hypertension (DASH) score. Child’s preschool wheezing and school-age asthma and lung function were measured by questionnaires and spirometry. We used multilevel regression models with a random intercept at cohort level to study the associations. Results: After adjustment for lifestyle and sociodemographic factors, we observed no consistent associations of a high E-DII score (>90th percentile) with respiratory outcomes, but a low DASH score ( Conclusion: A low quality maternal diet in pregnancy might have a modest adverse effect on respiratory health in childhood.
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- 2020
26. The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study
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Wojciech Hanke, Joanna Jerzyńska, Wojciech Wasowicz, Iwona Stelmach, Kinga Polańska, Jolanta Gromadzinska, and Monika Bobrowska-Korzeniowska
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Pulmonary and Respiratory Medicine ,Male ,Pediatrics ,medicine.medical_specialty ,Allergy ,Population ,Mothers ,01 natural sciences ,Antioxidants ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,Selenium ,0302 clinical medicine ,Food allergy ,Pregnancy ,medicine ,Hypersensitivity ,Immunology and Allergy ,Humans ,0101 mathematics ,Vitamin D ,Child ,Asthma ,business.industry ,010102 general mathematics ,General Medicine ,Atopic dermatitis ,medicine.disease ,Zinc ,030228 respiratory system ,chemistry ,Maternal Exposure ,Cord blood ,Prenatal Exposure Delayed Effects ,Female ,Poland ,business ,Cotinine ,Copper ,Cohort study - Abstract
Purpose: Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess the associations among cord blood concentrations of zinc (Zn); copper (Cu); selenium (Se); β-carotene; and vitamin A, E, and D, and the occurrence of atopic dermatitis, food allergy, allergic rhinitis, and asthma in early school-age children. Methods: We evaluated 211 children, 7‐9 years old, from the Polish Mother and Child Cohort Study. the women were interviewed during pregnancy to collect demographic and socioeconomic data, and the medical and reproductive history. At delivery, umbilical cord blood plasma was sampled. Seven to nine years after the birth, the child's exposure and health status (including skin-prick test and spirometry for allergy assessment and urine sample for cotinine level) were examined. In the analyses, a multivariable model was applied. Results: Statistically significant relationships were found among Zn; Cu; Se; and vitamin A, E, and D concentrations in cord blood; and the prevalence of food allergy, allergic rhinitis, atopic dermatitis, and asthma in children ages 7‐9 years after adjustment for several confounders. Conclusion: We showed an imbalance in the antioxidant defense system in cord blood, which may lead to the occurrence of allergic diseases later in life. The maternal diet may have substantial potential to modify immune tolerance and, consequently, the development of allergic disease in the offspring.Clinical trial NCT01861548, www.clinicaltrials.gov
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- 2020
27. Pet ownership and allergic sensitisation and asthma in childhood: findings from the EU Child Cohort Network
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Marisa Estarlich, Rosalie Mensink-Bout, Kinga Polańska, Johanna Thorbjørnsrud Nader, Angela Pinot de Moira, Anne-Marie Nybo Andersen, Rae-Chi Huang, Jennifer R. Harris, Vincent W. V. Jaddoe, Aitana Lertxundi, Tim Cadman, Tiffany Yang, Agnieszka Jankowska, Ana Esplugues, Maja Popovic, Hazel Inskip, Jordi Sunyer, Demetris Avraam, Ahmed Elhakeem, Debbie A Lawlor, Costanza Pizzi, Liesbeth Duijts, Katrine Strandberg-Larsen, Maribel Casas, Barbara Heude, Rachel E. Foong, Theodosia Salika, and Evelien R. van Meel
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Pediatrics ,medicine.medical_specialty ,business.industry ,Allergic sensitisation ,medicine.disease ,01 natural sciences ,Pet ownership ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Cohort ,medicine ,030212 general & internal medicine ,0101 mathematics ,business ,Asthma - Published
- 2020
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28. Maternal dietary quality, inflammatory potential and offspring adiposity throughout childhood: a pooled analysis of 7 European cohorts (ALPHABET consortium)
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Ling-Wei Chen, Fionnuala M. McAuliffe, James R. Hébert, Liesbeth Duijts, Barbara Heude, Matthew Suderman, Jonathan Y. Bernard, Kinga Polańska, Aisling A. Geraghty, Cyrus Cooper, Catherine M. Phillips, Cecily Kelleher, Rosalie Mensink-Bout, Nicholas C. Harvey, Adrien M. Aubert, Nitin Shivappa, John Mehegan, and Caroline L Relton
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Percentile ,Nutrition and Dietetics ,business.industry ,Offspring ,Medicine (miscellaneous) ,medicine.disease ,Obesity ,Childhood obesity ,Quartile ,Diet quality ,Dash ,Medicine ,business ,Parity (mathematics) ,Demography - Abstract
IntroductionThe foetal programming hypothesis posits that optimising early life factors e.g. maternal diets can help avert the burden of adverse childhood outcomes e.g. childhood obesity. To improve applicability to public health messaging, we investigated whether maternal whole diet quality and inflammatory potential influence childhood adiposity in a large consortium.MethodsWe harmonized and pooled individual participant data from up to 8,769 mother-child pairs in 7 European mother-offspring cohorts. Maternal early-, late-, and whole-pregnancy dietary quality and inflammatory potential were assessed with Dietary Approaches to Stop Hypertension (DASH) and energy-adjusted Dietary Inflammatory Index (E-DII), respectively. Primary outcome was childhood overweight and obesity (OWOB), defined as age- and sex-specific body-mass-index-z score (BMIz) > 85th percentile based on WHO growth standard. Secondary outcomes were sum-of-skinfold-thickness (SST), fat-mass-index (FMI) and fat-free-mass-index (FFMI) in available cohorts. Outcomes were assessed in early- [mean (SD) age: 2.8 (0.3) y], mid- [6.2 (0.6) y], and late-childhood [10.6 (1.2) y]. We used multivariable regression analyses to assess the associations of maternal E-DII and DASH with offspring adiposity outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Analyses were adjusted for maternal age, pre-pregnancy BMI, parity, lifestyle factors, energy intake, educational attainment, offspring age and sex.ResultsA more pro-inflammatory maternal diet, indicated by higher E-DII, was associated with a higher risk of offspring late-childhood OWOB [pooled-OR (95% CI) comparing highest vs. lowest E-DII quartiles: 1.22 (1.01,1.47) for whole-pregnancy and 1.38 (1.05,1.83) for early-pregnancy; both P < 0.05]. Moreover, higher late-pregnancy E-DII was associated with higher mid-childhood FMI [pooled-β (95% CI): 0.11 (0.003,0.22) kg/m2; P < 0.05]; trending association was observed for whole-pregnancy E-DII [0.12 (-0.01,0.25) kg/m2; P = 0.07]. A higher maternal dietary quality, indicated by higher DASH score, showed a trending inverse association with late-childhood OWOB (pooled-OR (95% CI) comparing highest vs. lowest DASH quartiles: 0.58 (0.32,1.02; P = 0.06). Higher early-pregnancy DASH was associated with lower late-childhood SST [pooled-β (95% CI): -1.9 (-3.6,-0.1) cm; P < 0.05] and tended to be associated with lower late-childhood FMI [-0.34 (-0.71,0.04) kg/m2; P = 0.08]. Higher whole-pregnancy DASH tended to associate with lower early-childhood SST [-0.33 (-0.72,0.06) cm; P = 0.10]. Results were similar when modelling DASH and E-DII continuously.DiscussionAnalysis of pooled data suggests that pro-inflammatory, low-quality maternal antenatal diets may influence offspring body composition and obesity risk, especially during mid- or late-childhood. Due to variation of data availability at each timepoint, our results should be interpreted with caution. Because most associations were observed at mid-childhood or later, future studies will benefit from a longer follow-up.
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- 2020
29. Socio-demographic and lifestyle determinants of the micronutrients status during pregnancy
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Kinga Polańska, Wojciech Hanke, Jolanta Gromadzinska, Beata Janasik, Agnieszka Jankowska, Elżbieta Trafalska, Wojciech Wasowicz, Ewelina Wesołowska, Calamandrei G, and Paweł Kałużny
- Subjects
Pregnancy ,business.industry ,Environmental health ,Socio demographics ,Public Health, Environmental and Occupational Health ,Medicine ,business ,Micronutrient ,medicine.disease - Abstract
Micronutrients status during pregnancy is recognized as one of the environmental factors that can have an impact on maternal and children’s health. The study aims at evaluating sociodemographic, lifestyle, environmental, and pregnancy-related determinants of maternal micronutrients status during pregnancy. The analysis was based on data from the Polish Mother and Child Cohort (REPRO_PL). During the second trimester of pregnancy, 1306 women filled in a modified version of the validated food frequency questionnaire (FFQ) based on which the intake of the following micronutrients was estimated: calcium, magnesium, zinc, copper, selenium, folate, vitamin D, vitamin A and vitamin E. In addition, copper, zinc and selenium levels were measured in the blood collected during the second trimester of pregnancy. About 95% of the women took dietary supplements during pregnancy. Despite such supplementation in the case of a high proportion of the women the intake of majority of the analyzed micronutrients was below recommendations for the pregnancy period (based on the Estimated Average Requirement). The mean plasma zinc, copper and selenium concentrations were 0.9±0.3 mg/l, 2.0±0.6 mg/l and 48.4±10.5 ug/l, respectively. The chance to reach the recommended intake for vitamin A, vitamin D and selenium was higher among the multiparous women (OR = 1.53 p = 0.007; OR = 1.44 p = 0.02; OR = 1.48 p = 0.009) and for zinc among the women with a higher socio-economic status (SES) (OR = 1.43 p = 0.04). For other variables the results were not statistically significant. A higher selenium level in the plasma was observed among the older women (p = 0.01) and those with a higher SES (p = 0.03). The current study presents evidence on specific factors influencing the micronutrients intake. They need to be accounted for in educational programs and interventions that focus on healthy diet recommendations during pregnancy. Key messages In the case of a high proportion of the women the intake of majority of the analyzed micronutrients was below recommendations for the pregnancy period. More effort should be taken to educational programs and interventions that focus on healthy diet recommendations during pregnancy.
- Published
- 2019
30. Predictors of Counselling Related to a Healthy Lifestyle Carried Out by a General Practitioner
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Piotr Wojtysiak, Dorota Kaleta, Justyna Zajdel-Całkowska, Michał Szulc, Leokadia Bąk-Romaniszyn, Kinga Polańska, Małgorzata Znyk, Teresa Makowiec-Dąbrowska, and Nofer Institute of Occupational Medicine
- Subjects
Adult ,Counseling ,Male ,medicine.medical_specialty ,Attitude of Health Personnel ,Health, Toxicology and Mutagenesis ,Population ,Physical activity ,Health Promotion ,Article ,chronic diseases ,primary care ,Patient Education as Topic ,General Practitioners ,healthy lifestyle ,Surveys and Questionnaires ,health education ,Medicine ,Humans ,education ,education.field_of_study ,business.industry ,Public sector ,Public Health, Environmental and Occupational Health ,Weight control ,Middle Aged ,health behaviors ,Cross-Sectional Studies ,Family medicine ,Assisted GPS ,general practitioner ,Chronic Disease ,Health education ,Female ,Poland ,Health behavior ,business ,Lifestyle counselling - Abstract
The aim of the study was to assess whether general practitioners (GPs) monitor and evaluate the health behavior of their patients in the field of a diet, physical activity, and weight control, and whether they provide appropriate counselling as part of this evaluation. Predictors of those activities among physicians were also determined. The cross-sectional study was conducted in the Piotrkowski district among 200 GPs. The questionnaire covered socio-demographic data and lifestyle characteristics of the physicians, their role as healthy lifestyle providers, and whether they assess lifestyle characteristics of their patients and perform healthy lifestyle counselling. More than 60% of the GPs did not evaluate lifestyle features during their patients&rsquo, examination. In total, 56% of the GPs provided healthy lifestyle recommendations among patients who have not been diagnosed with chronic lifestyle-related diseases but who do not follow healthy recommendations, and 73% of GPs provided recommendations to patients with chronic diseases related to lifestyle. The study showed that the chance to assess lifestyle characteristics of the patients was significantly higher for the GPs who believed that they were obliged to do so (OR = 6.5, p = 0.002). The chance to recommend a healthy lifestyle among patients who have not been diagnosed with chronic lifestyle-related diseases but who do not follow healthy recommendations was 5.9 times higher among the GPs working in the public sector (p <, 0.001) and 16.3 times higher for these who believed that they had sufficient knowledge to provide the advice (p = 0.02). The following predictors of providing a healthy lifestyle counselling among patients with diagnosed chronic lifestyle-related diseases were identified: conviction that a GPs is obligated to provide it (OR = 4.4, p = 0.02), sufficient knowledge (OR = 8.7, p = 0.01), and following health recommendations by themselves (OR = 3.9, p = 0.04). Conclusions: The identified predictors are crucial for the development of appropriate strategies aiming at increasing GPs&rsquo, involvement in preventive measures and consequently at improving the population&rsquo, s health.
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- 2019
31. Sociodemographic determinants for initiation and duration of breastfeeding – Polish Mother and Child Cohort Study
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Anna Król, Michał Seweryn Karbownik, Wojciech Hanke, Włodzimierz Stelmach, Paulina Kwarta, Kinga Polańska, Iwona Stelmach, Jan Krakowiak, Joanna Jerzyńska, and Nofer Institute of Occupational Medicine
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Sociodemographic determinants ,breastfeeding ,business.industry ,socio-demographic factors ,Pediatrics, Perinatology and Child Health ,Breastfeeding ,Medicine ,Duration (project management) ,business ,Demography ,Cohort study - Published
- 2018
32. Maternal stress during pregnancy and neurodevelopmental outcomes of children during the first 2 years of life
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Kinga Polańska, Wojciech Hanke, Anna Król, Joanna Jurewicz, Dorota Merecz-Kot, Gemma Calamandrei, Teresa Makowiec-Dabrowska, and Flavia Chiarotti
- Subjects
Psychomotor learning ,Pregnancy ,business.industry ,Perceived Stress Scale ,medicine.disease ,Child development ,Bayley Scales of Infant Development ,03 medical and health sciences ,0302 clinical medicine ,Prenatal stress ,Pediatrics, Perinatology and Child Health ,Medicine ,030212 general & internal medicine ,Occupational stress ,Toddler ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Aim A growing body of literature documents associations between maternal stress in pregnancy and child development, but findings across studies are often inconsistent. The aim of this study was to estimate the association between exposure to different kinds of prenatal stress and child psychomotor development. Methods The study population consisted of 372 mother-child pairs from Polish Mother and Child Cohort. The analysis was restricted to the women who worked at least 1 month during pregnancy period. Maternal psychological stress during pregnancy was assessed based on: the Subjective Work Characteristics Questionnaire, Perceived Stress Scale and Social Readjustment Rating Scale. The level of satisfaction with family functioning and support was evaluated by APGAR Family Scale. Child psychomotor development was assessed at the 12th and 24th months of age by Bayley Scales of Infant and Toddler Development. Results Negative impact on child cognitive development at the age of two was observed for the Perceived Stress Scale (β = −0.8; P = 0.01) and the Social Readjustment Rating Scale (β = −0.4; P = 0.03) after adjusting for the variety of confounders. Occupational stress, as well as satisfaction with family functioning, was not significantly associated with child psychomotor development (P > 0.05). Conclusions The study supports the findings that prenatal exposure to maternal stress is significantly associated with decreased child cognitive functions. In order to further understand and quantify the effects of prenatal stress on child neurodevelopment further studies are needed. This will be important for developing interventions that provide more assistance to pregnant women, including emotional support or help to manage psychological stress.
- Published
- 2017
33. Early life environmental exposure in relation to new onset and remission of allergic diseases in school children: Polish Mother and Child Cohort Study
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Kinga Polańska, Karolina Mikołajewska, Włodzimierz Stelmach, Wojciech Hanke, Jolanta Gromadzinska, Iwona Stelmach, Monika Bobrowska-Korzeniowska, K Kapszewicz, and Joanna Jerzyńska
- Subjects
Pulmonary and Respiratory Medicine ,Male ,Pediatrics ,medicine.medical_specialty ,Allergy ,Mothers ,medicine.disease_cause ,Dermatitis, Atopic ,Cohort Studies ,Allergen ,Food allergy ,Recurrence ,Surveys and Questionnaires ,medicine ,Hypersensitivity ,Immunology and Allergy ,Animals ,Humans ,Child ,Cotinine ,Asthma ,Skin Tests ,business.industry ,Incidence (epidemiology) ,Pyroglyphidae ,Age Factors ,Infant ,General Medicine ,Atopic dermatitis ,Environmental exposure ,Environmental Exposure ,medicine.disease ,Female ,Poland ,business ,Food Hypersensitivity ,Cohort study - Abstract
Background: This study was based on data from the Polish Mother and Child Cohort Study. Objective: The aim was to study associations between home environment factors and allergic diseases at 1 year of life and new onset and remission of children's allergy diagnosis at ages 7-9 years. Methods: Children's health status was assessed at ∼12 months of age and then at ages between 7-9 years by using a questionnaire administered to the mothers. Children were assessed by pediatrician/allergists. The patients, who were 7-9 years old, underwent skin-prick tests. Exposure to tobacco smoke was evaluated with a questionnaire addressed to parents and/or caregivers and cotinine measurements were taken of mother's saliva during pregnancy and in children's urine at ages 7-9 years. Incidence and remission were calculated by comparing symptoms in the first year of life with symptoms at 7-9 years. We studied the associations among demographic data, home environment, and new onset and remission of food allergy, atopic dermatitis, and asthma and allergic rhinitis in logistic regression analysis. All associations were adjusted for independent risk factors of dependent variables. Results: Data from 211 participants were included in the analysis. During the first year of life, food allergy was the most common symptom (39%), followed by atopic dermatitis (35%) and asthma (12%). When comparing diagnoses at ages 7-9 years with the first year of life, food allergy had decreased by as much as 18.6%, atopic dermatitis decreased by as much as 23.8%, and asthma decreased by as much as 8%, whereas asthma and allergic rhinitis had increased from 6% to 14.8%. More frequent house cleaning negatively correlated with the new onset of atopic dermatitis and of asthma and allergic rhinitis. Hypersensitivity to seasonal allergens and mites and to any other allergen positively correlated with new onset of food allergy, atopic dermatitis, and asthma and allergic rhinitis. Parental atopy positively correlated with the new onset of asthma and negatively correlated with asthma remission. Conclusion: Analysis of our findings indicated that new onset and/or remission of allergic diseases was linked with hypersensitivity to house-dust mites in children who were polysensitized and with parental atopy. In addition, children who had food allergy, allergic rhinitis, or atopic dermatitis at the age of 1 year had more of a chance developing other atopic disease (except asthma) at ages 7-9 years and less of a chance of having a remission of the disease.
- Published
- 2019
34. Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years - Polish Mother and Child Cohort
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Kinga Polańska, Wojciech Hanke, Danuta Ligocka, Małgorzata Waszkowska, Aleksander Stańczak, Anna Maria Tartaglione, Gemma Calamandrei, Mercè Garí, Agnieszka Jankowska, Flavia Chiarotti, Fiorino Mirabella, and Ewelina Wesołowska
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Phthalic Acids ,Mothers ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Child Development ,Pregnancy ,Medicine ,Humans ,030212 general & internal medicine ,Early childhood ,Child ,0105 earth and related environmental sciences ,General Environmental Science ,Psychomotor learning ,business.industry ,Phthalate ,Neuropsychology ,Strengths and Difficulties Questionnaire ,Environmental Exposure ,medicine.disease ,chemistry ,Child, Preschool ,Cohort ,Environmental Pollutants ,Female ,Poland ,business ,Clinical psychology ,Cohort study - Abstract
Phthalates are among the most frequently investigated environmental chemicals influencing children's health and particularly their neuropsychological development. However, the reported effects of these compounds on child behavior, cognitive and psychomotor outcomes are not fully consistent. The aim of this study is to evaluate the associations between prenatal and early postnatal phthalate exposures and child neurodevelopment at age of 7 years. A total of 134 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL) constitute the basis for current analysis. Eleven phthalate metabolites were measured in urine samples collected from mothers in the 3rd trimester of pregnancy and from children at the age of 2 years. Child neuropsychological development at early school age (7 years) was assessed by both the Strengths and Difficulties Questionnaire (SDQ) filled by mothers and the Polish adaptation of the Intelligence and Development Scales (IDS) performed by psychologists. Mono-ethyl phthalate (MEP) concentration during pregnancy was significantly associated with increased risk of peer relationship problems in SDQ (OR = 2.7, p = 0.03). The results of the IDS analyses focused on child's cognitive and psychomotor development are not fully conclusive. Negative associations were evident between some phthalates in early childhood period and fluid intelligence and cognition (MEP: β = −5.2; p = 0.006; β = −4.2; p = 0.006; mono-n-butyl phthalate (MnBP): β = −4.9; p = 0.03; β = −4.0; p = 0.03; respectively), while positive associations have been found in the prenatal period (mono-2-ethyl-5-oxo-hexyl phthalate (oxo-MEHP): β = 3.6; p = 0.03 for fluid intelligence; β = 2.9; p = 0.03 for cognition). Further studies are required in order to elucidate which are the most critical periods of phthalate exposure on children's neurodevelopmental outcomes.
- Published
- 2019
35. Pregnancy exposome and child psychomotor development in three European birth cohorts
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Inge Vlašić-Cicvarić, Darja Mazej, Staša Stropnik, Anna Maria Tartaglione, Zdravko Špirić, Milena Horvat, Jana Kodrič, Ettore Meccia, Gemma Calamandrei, Beata Janasik, Fiorino Mirabella, Renata Kuraś, Kinga Polańska, Janja Snoj Tratnik, David Neubauer, Laura Ricceri, Igor Prpić, and Flavia Chiarotti
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Male ,Exposome ,Multivariate statistics ,BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences ,Croatia ,Slovenia ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,Bayley Scales of Infant Development ,03 medical and health sciences ,0302 clinical medicine ,Child Development ,Pregnancy ,Environmental health ,Prenatal exposure ,medicine ,Humans ,030212 general & internal medicine ,Micronutrients ,Prospective Studies ,Toddler ,Prospective cohort study ,0105 earth and related environmental sciences ,General Environmental Science ,Psychomotor learning ,business.industry ,BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti ,BIOTEHNIČKE ZNANOSTI. Biotehnologija ,Infant ,Environmental Exposure ,medicine.disease ,Developmental neurotoxicity ,Metals ,BIOTECHNICAL SCIENCES. Biotechnology ,Europe ,Prenatal Exposure Delayed Effects ,Cohort ,Female ,Poland ,business - Abstract
Characterization of the exposome, the totality of all environmental factors that one is exposed to from conception onwards, has been recommended to better evaluate the role of environmental influences on developmental programming and life- course vulnerability to major chronic diseases. In the framework of the Health and Environment- wide Associations based on Large population Surveys (HEALS) project we considered the pregnancy exposome exploiting two databases (PRIME and REPRO PL) that include birth cohorts from three EU countries (Croatia, Slovenia and Poland). The databases contained information on several chemical exposures, socio-demographic, lifestyle and health related factors from conception to child birth, and neuropsychological scores assessed by the Bayley Scales of Infant and Toddler Development in the first two years of life. Our main goal was to assess consistency of environmental influences on neurodevelopment, if any, across European countries differing for geographical, socio-demographic characteristics and levels of chemical exposures to metals such as lead (Pb), mercury (Hg), cadmium (Cd) and trace elements, including micronutrients such as zinc (Zn) and selenium (Se). To this aim, we first selected variables common to the different databases, then applied univariate and multivariate regression analyses to identify factors linked to neurodevelopment, and finally performed meta-analysis to detect potential heterogeneity among cohorts and pooled estimates. Significant differences in exposure levels among the three sub-cohorts were observed as for Hg and Se ; exposure levels under study were relatively low and within the range described in existing EU biomonitoring studies. The univariate analyses did not show any common pattern of association as only in the Polish cohort chemical exposure had an impact on neuropsychological outcome. In the meta-analysis, some consistent trends were evident, relative to the adverse influence of Pb on children's language and cognition and the positive influence of Se on language abilities. The effects of the neurotoxic metal Hg positively influenced the motor scores in the Polish cohorts, while it decreased the motor scores in the Slovenia and Croatian sub-cohorts. The only socio-demographic factor consistently associated to the outcome among cohorts was child's sex, with females performing better than males on cognitive and language scores. These findings point to the need of harmonizing existing cohorts or creating prospective study designs that facilitate comparisons in the exposome over time, places and kind of environmental exposures.
- Published
- 2019
36. Dietary Inflammatory Index and Non-Communicable Disease Risk: A Narrative Review
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Kinga Polańska, Catherine M. Phillips, James R. Hébert, Matthew Suderman, Nitin Shivappa, Jonathan Y. Bernard, Nicholas C. Harvey, Liesbeth Duijts, Ling-Wei Chen, Barbara Heude, Giulia Mancano, Sara M. Mensink-Bout, Erasmus MC other, Pediatrics, and Nofer Institute of Occupational Medicine
- Subjects
0301 basic medicine ,Gerontology ,obesity ,respiratory health ,Developmental Disabilities ,Respiratory Tract Diseases ,MEDLINE ,lcsh:TX341-641 ,030209 endocrinology & metabolism ,Review ,Disease ,Systemic inflammation ,metabolic syndrome ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Neoplasms ,Diabetes mellitus ,medicine ,Humans ,cancer ,Musculoskeletal Diseases ,bone health ,Noncommunicable Diseases ,Inflammation ,Metabolic Syndrome ,030109 nutrition & dietetics ,Nutrition and Dietetics ,neurodevelopment ,business.industry ,Mental Disorders ,Feeding Behavior ,Non-communicable disease ,medicine.disease ,Mental health ,Obesity ,Diet ,3. Good health ,Cardiovascular Diseases ,inflammation ,dietary inflammatory index ,Metabolic syndrome ,medicine.symptom ,business ,lcsh:Nutrition. Foods and food supply ,mental health ,cardiometabolic health ,Food Science - Abstract
There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII®), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children’s DII (C-DII) scores and new avenues of investigation in this field of nutritional research.
- Published
- 2019
37. Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
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Wojciech Hanke, George P. Chrousos, Myriam Doyon, Daniela Porta, Nel Roeleveld, Pilar Amiano, Johanna Mäkelä, Davide Gori, Lorenzo Richiardi, Marie-Aline Charles, Romy Gaillard, Camilla Schmidt Morgen, Leda Chatzi, Vagelis Georgiu, Juha Pekkanen, Andrea von Berg, Carel Thijs, Sheryl L. Rifas-Shiman, George Moschonis, Yannis Manios, Per Magnus, Anne-Marie Nybo Andersen, M. Standl, Oleksandr Zvinchuk, Camilla Stoltenberg, Eleni Papadopoulou, Renata Majewska, Carmen Iñiguez, Monique Mommers, Susana Santos, Anne M. Karvonen, Hazel Inskip, Sara Farchi, L. Ronfani, Vincent W. V. Jaddoe, E. Thiering, Maties Torrent, Marleen M.H.J. van Gelder, Sarah Crozier, Keith M. Godfrey, Martine Vrijheid, Hein Stigum, Debbie A Lawlor, Barbara Heude, Tomas Trnovec, Ellis Voerman, Leanne K. Küpers, Maria Pia Fantini, Ellen A. Nohr, Eva Corpeleijn, Henrique Barros, D. Hryhorczuk, Irva Hertz-Picciotto, LifeCycle Project-Maternal Obesity, Ana Cristina Santos, Merete Eggesbø, Alet H. Wijga, Marie-France Hivert, Agnieszka Pac, Irina Lehmann, Emily Oken, Costanza Pizzi, Francesco Forastiere, Lenie van Rossem, Kinga Polańska, Hanna Lagström, Thorkild I. A. Sørensen, Erasmus MC other, Pediatrics, Epidemiology, Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, Epidemiologie, and RS: CAPHRI - R5 - Optimising Patient Care
- Subjects
Gestational hypertension ,Nutrition and Disease ,01 natural sciences ,Body Mass Index ,0302 clinical medicine ,Pregnancy ,Voeding en Ziekte ,Medicine ,Birth Weight ,030212 general & internal medicine ,Obstetrics ,Diabetes ,Pregnancy Outcome ,Gestational age ,General Medicine ,Cesarean Section/statistics & numerical data ,Adult ,Cesarean Section ,Diabetes, Gestational ,Female ,Humans ,Hypertension, Pregnancy-Induced ,Infant, Newborn ,Obesity ,Premature Birth ,Gestational Weight Gain ,Pregnancy Complications ,Gestational diabetes ,Premature birth ,Gestational ,Hypertension ,medicine.symptom ,Underweight ,PREGNANT-WOMEN ,medicine.medical_specialty ,Birth weight ,Pregnancy-Induced ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Life Science ,0101 mathematics ,business.industry ,010102 general mathematics ,Infant ,medicine.disease ,Newborn ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,BODY-MASS INDEX ,business ,Body mass index ,Weight gain - Abstract
Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, setting, and participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated for each prepregnancy body mass index (BMI) category by selecting the range of gestational weight gain that was associated with lower risk for any adverse outcome. Individual participant-level data from 3505 participants within 4 separate hospital-based cohorts were used as a validation sample. Data were collected between 1989 and 2015. The final date of follow-up was December 2015. Exposures: Gestational weight gain. Main outcomes and measures: The main outcome termed any adverse outcome was defined as the presence of 1 or more of the following outcomes: preeclampsia, gestational hypertension, gestational diabetes, cesarean delivery, preterm birth, and small or large size for gestational age at birth. Results: Of the 196 670 women (median age, 30.0 years [quartile 1 and 3, 27.0 and 33.0 years] and 40 937 were white) included in the main sample, 7809 (4.0%) were categorized at baseline as underweight (BMI
- Published
- 2019
38. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis
- Author
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Vincent W. V. Jaddoe, Deirdre M. Murray, Juha Pekkanen, Anne M. Karvonen, Martine Vrijheid, Kinga Polańska, Oleksandr Zvinchuk, Johanna Mäkelä, Louise C. Kenny, Costanza Pizzi, Adriette J. J. M. Oostvogels, Debbie A Lawlor, Elisabeth Thiering, Sara Farchi, Bernadeta Patro Golab, Ellis Voerman, Sheryl L. Rifas-Shiman, George Moschonis, Rae-Chi Huang, Suzanne Tough, Camilla Stoltenberg, John Wright, Jane West, Irina Lehmann, Wojciech Hanke, Leda Chatzi, Hanna Lagström, Henrique Barros, Keith M. Godfrey, Graham Devereux, Barbara Heude, Emily Oken, Lorenzo Richiardi, Francesco Forastiere, Tomas Trnovec, Andrea von Berg, Cécile Chevrier, Ellen A. Nohr, Maria Pia Fantini, Sheila McDonald, Carol Ní Chaoimh, Tanja G. M. Vrijkotte, Maties Torrent, Davide Gori, Anna Bergström, Anne-Marie Nybo Andersen, Nathalie Costet, Marie-Aline Charles, Veit Grote, Lenie van Rossem, Alet H. Wijga, Daniel O. Hryhorczuk, Yannis Manios, Trevor A. Mori, Monique Mommers, Renata Majewska, John Mehegan, Hazel Inskip, Romy Gaillard, Camilla Schmidt Morgen, George P. Chrousos, Thorkild I. A. Sørensen, Pilar Amiano, Eleni Papadopoulou, Nina Iszatt, Sarah Crozier, Carel Thijs, Irva Hertz-Picciotto, Sandra Ekström, Leanne K. Küpers, Ana Cristina Santos, Ferran Ballester, Fionnuala M. McAuliffe, Marie Standl, Luca Ronfani, Merete Eggesbø, Eva Corpeleijn, Agnieszka Pac, Berthold Koletzko, Vagelis Georgiu, Susana Santos, Daniela Porta, Per Magnus, Steve Turner, Ma, Ronald CW, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Keck School of Medicine [Los Angeles], University of Southern California (USC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Azienda Sanitaria Locale [ROMA] (ASL), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Voerman, Elli, Santos, Susana, Patro Golab, Bernadeta, Amiano, Pilar, Ballester, Ferran, Barros, Henrique, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P., Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbø, Merete, Ekström, Sandra, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vageli, Godfrey, Keith M., Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Iszatt, Nina, Karvonen, Anne M., Kenny, Louise C., Koletzko, Berthold, Küpers, Leanne K., Lagström, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yanni, McAuliffe, Fionnuala M., McDonald, Sheila W., Mehegan, John, Mommers, Monique, Morgen, Camilla S., Mori, Trevor A., Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nohr, Ellen A., Nybo Andersen, Anne-Marie, Oken, Emily, Oostvogels, Adriëtte J J M, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L., Ronfani, Luca, Santos, Ana C., Standl, Marie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Matie, Tough, Suzanne C., Trnovec, Toma, Turner, Steve, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja G M, West, Jane, Wijga, Alet, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild I A, Lawlor, Debbie A., Gaillard, Romy, Jaddoe, Vincent W V, Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Nofer Institute of Occupational Medicine, ARD - Amsterdam Reproduction and Development, Public and occupational health, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, APH - Methodology, Veterinary Biosciences, Department of Public Health, University of Helsinki, and Clinicum
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Data Analysis ,embarazo ,Maternal Health ,Blood Pressure ,CHILDREN ,Weight Gain ,Cardiovascular ,Vascular Medicine ,Body Mass Index ,0302 clinical medicine ,Endocrinology ,Pregnancy ,Medicine ,Mass index ,estudios de cohortes ,Cancer ,030219 obstetrics & reproductive medicine ,Statistics ,WOMEN ,ta3141 ,General Medicine ,030220 oncology & carcinogenesis ,Meta-analysis ,Physical Sciences ,Gestation ,HEALTH ,INTERVENTION ,Childhood Obesity ,Endocrine Disorders ,03 medical and health sciences ,Hypertensive Disorders in Pregnancy ,Clinical Research ,Diabetes Mellitus ,Humans ,Gestational Diabetes ,Statistical Methods ,Individual participant data ,Prevention ,Australia ,Biology and Life Sciences ,Odds ratio ,medicine.disease ,Obesity ,Generic health relevance ,Body mass index ,Mathematics ,Demography ,Pediatric Obesity ,Nutrition and Disease ,Physiology ,humanos ,Reproductive health and childbirth ,030204 cardiovascular system & hematology ,Overweight ,Medical and Health Sciences ,Oral and gastrointestinal ,Cohort Studies ,Mathematical and Statistical Techniques ,Risk Factors ,Voeding en Ziekte ,OFFSPRING OBESITY ,Medicine and Health Sciences ,030212 general & internal medicine ,Childhood obesity ,2. Zero hunger ,Pediatric ,sobrepeso ,Medicine (all) ,Obstetrics and Gynecology ,Metaanalysis ,3142 Public health care science, environmental and occupational health ,Gestational Weight Gain ,obesidad pediátrica ,Europe ,Stroke ,PREGNANCY ,Physiological Parameters ,gestational weight gain, pregnancy, obesity ,Hypertension ,Female ,medicine.symptom ,Research Article ,BIRTH ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Research and Analysis Methods ,General & Internal Medicine ,factores de riesgo ,Life Science ,Metabolic and endocrine ,Nutrition ,business.industry ,índice de masa corporal ,Body Weight ,3121 General medicine, internal medicine and other clinical medicine ,Metabolic Disorders ,North America ,Women's Health ,business ,Maternal body ,Gestiational diabetes ,Weight gain - Abstract
Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Methods and findings We conducted an individual participant data meta-analysis of data from 162,129 mothers and their children from 37 pregnancy and birth cohort studies from Europe, North America, and Australia. We assessed the individual and combined associations of maternal pre-pregnancy BMI and gestational weight gain, both in clinical categories and across their full ranges, with the risks of overweight/obesity in early (2.0–5.0 years), mid (5.0–10.0 years) and late childhood (10.0–18.0 years), using multilevel binary logistic regression models with a random intercept at cohort level adjusted for maternal sociodemographic and lifestyle-related characteristics. We observed that higher maternal pre-pregnancy BMI and gestational weight gain both in clinical categories and across their full ranges were associated with higher risks of childhood overweight/obesity, with the strongest effects in late childhood (odds ratios [ORs] for overweight/obesity in early, mid, and late childhood, respectively: OR 1.66 [95% CI: 1.56, 1.78], OR 1.91 [95% CI: 1.85, 1.98], and OR 2.28 [95% CI: 2.08, 2.50] for maternal overweight; OR 2.43 [95% CI: 2.24, 2.64], OR 3.12 [95% CI: 2.98, 3.27], and OR 4.47 [95% CI: 3.99, 5.23] for maternal obesity; and OR 1.39 [95% CI: 1.30, 1.49], OR 1.55 [95% CI: 1.49, 1.60], and OR 1.72 [95% CI: 1.56, 1.91] for excessive gestational weight gain). The proportions of childhood overweight/obesity prevalence attributable to maternal overweight, maternal obesity, and excessive gestational weight gain ranged from 10.2% to 21.6%. Relative to the effect of maternal BMI, excessive gestational weight gain only slightly increased the risk of childhood overweight/obesity within each clinical BMI category (p-values for interactions of maternal BMI with gestational weight gain: p = 0.038, p < 0.001, and p = 0.637 in early, mid, and late childhood, respectively). Limitations of this study include the self-report of maternal BMI and gestational weight gain for some of the cohorts, and the potential of residual confounding. Also, as this study only included participants from Europe, North America, and Australia, results need to be interpreted with caution with respect to other populations. Conclusions In this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy., Vincent Jaddoe and colleagues report that a high BMI before pregnancy, rather than excessive gestational weight gain, is more likely to contribute to childhood obesity., Author summary Why was this study done? Maternal pre-pregnancy obesity and excessive gestational weight gain are important risk factors of various pregnancy and birth complications. An accumulating body of evidence suggests that maternal obesity and excessive gestational weight gain also have persistent effects on offspring fat development. It is not clear whether these effects exist across the full ranges of maternal pre-pregnancy body mass index and gestational weight gain, what their combined effects are, and what the population impact of these effects is. What did the researchers do and find? We conducted an individual participant data meta-analysis using data from 162,129 mothers and their children from 37 pregnancy and birth cohorts from Europe, North America, and Australia to assess the separate and combined associations of maternal pre-pregnancy body mass index and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. We observed not only that maternal pre-pregnancy overweight and obesity were associated with an increased risk of childhood overweight/obesity, but that this risk increased gradually over the full range of maternal BMI. Similarly, the risk of childhood overweight/obesity increased across the full range of gestational weight gain. We estimated that 21.7% to 41.7% of childhood overweight/obesity prevalence could be attributed to maternal overweight and obesity together, whereas 11.4% to 19.2% could be attributed to excessive gestational weight gain. The additional effect of excessive gestational weight gain on the risk of childhood overweight/obesity was small among women who are already overweight or obese before pregnancy. What do these findings mean? Maternal pre-pregnancy BMI and, to a smaller extent, gestational weight gain are important modifiable risk factors of childhood overweight/obesity with considerable population impact. Future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight status during pregnancy.
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- 2019
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39. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts
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Eleni Papadopoulou, Andrea von Berg, Camilla Stoltenberg, Luca Ronfani, Romy Gaillard, Marie Standl, Martine Vrijheid, Sheila McDonald, Yannis Manios, Anne M. Karvonen, Marie-Aline Charles, George P. Chrousos, Daniela Porta, Anne-Marie Nybo Andersen, Keith M. Godfrey, Carol Ní Chaoimh, Costanza Pizzi, Marleen M.H.J. van Gelder, Lawrence J. Beilin, Ana Cristina Santos, Camilla Schmidt Morgen, Monique Mommers, Hazel Inskip, Alet H. Wijga, Per Magnus, Marie-France Hivert, Nel Roeleveld, Lenie van Rossem, Tanja G. M. Vrijkotte, Barbara Heude, Jane West, Steve Turner, Myriam Doyon, Thorkild I. A. Sørensen, Adriëtte J J M Oostvogels, Carel Thijs, Erik Melén, Merete Eggesbø, Maties Torrent, Irina Lehmann, Davide Gori, Susana Santos, Emily Oken, Berthold Koletzko, Ellis Voerman, John Wright, Agnieszka Pac, Pilar Amiano, Sarah Crozier, John Mehegan, Hein Stigum, Louise C. Kenny, Vincent W. V. Jaddoe, Deirdre M. Murray, Debbie A Lawlor, Francesco Forastiere, Johanna Mäkelä, Lorenzo Richiardi, Anna Bergström, Fionnuala M. McAuliffe, Elisabeth Thiering, Nathalie Costet, Hanna Lagström, Juha Pekkanen, Sheryl L. Rifas-Shiman, George Moschonis, Renata Majewska, Kinga Polańska, Rae-Chi Huang, Graham Devereux, Veit Grote, Leanne K. Küpers, Irva Hertz-Picciotto, Eva Corpeleijn, Ellen A. Nohr, Leda Chatzi, Olga Costa, Oleksandr Zvinchuk, Sara Farchi, Cécile Chevrier, Vagelis Georgiu, Tomas Trnovec, Henrique Barros, Maria Pia Fantini, Suzanne Tough, Wojciech Hanke, Daniel O. Hryhorczuk, Pediatrics, Erasmus MC other, Epidemiology, Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, ARD - Amsterdam Reproduction and Development, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, Public and occupational health, APH - Methodology, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Keck School of Medicine [Los Angeles], University of Southern California (USC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Azienda Sanitaria Locale [ROMA] (ASL), Norwegian Institute of Public Health [Oslo] (NIPH), Santos, Susana, Voerman, Elli, Amiano, Pilar, Barros, Henrique, Beilin, Lawrence J, Bergström, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costa, Olga, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Doyon, Myriam, Eggesbø, Merete, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vageli, Godfrey, Keith M, Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hivert, Marie-France, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Karvonen, Anne M, Kenny, Louise C, Koletzko, Berthold, Küpers, Leanne K, Lagström, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yanni, McAuliffe, Fionnuala M, McDonald, Sheila W, Mehegan, John, Melén, Erik, Mommers, Monique, Morgen, Camilla S, Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ní, Nohr, Ellen A, Nybo Andersen, Anne-Marie, Oken, Emily, Oostvogels, Adriëtte J J M, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Roeleveld, Nel, Ronfani, Luca, Santos, Ana C, Standl, Marie, Stigum, Hein, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Matie, Tough, Suzanne C, Trnovec, Toma, Turner, Steve, van Gelder, Marleen M H J, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja G M, West, Jane, Wijga, Alet H, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild I A, Lawlor, Debbie A, Gaillard, Romy, Jaddoe, Vincent W V, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Public Health, and University of Helsinki
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Gestational hypertension ,and promotion of well-being ,Nutrition and Disease ,Birthweight ,Reproductive health and childbirth ,Low Birth Weight and Health of the Newborn ,Cardiovascular ,Medical and Health Sciences ,DISEASE ,Cohort Studies ,0302 clinical medicine ,3123 Gynaecology and paediatrics ,Risk Factors ,Pregnancy ,Voeding en Ziekte ,Infant Mortality ,Odds Ratio ,Medicine ,Birth Weight ,2.1 Biological and endogenous factors ,EPIDEMIOLOGY ,wq_200 ,Aetiology ,2. Zero hunger ,Pediatric ,RISK ,education.field_of_study ,OUTCOMES ,030219 obstetrics & reproductive medicine ,Obstetrics ,pregnancy complications ,Diabetes ,Obstetrics and Gynecology ,Gestational age ,weight gain ,ASSOCIATION ,Gestational Weight Gain ,Gestational diabetes ,Europe ,Body Mass Index ,Pregnancy Complications ,Preterm Birth ,Weight Gain ,OBESITY ,Female ,medicine.symptom ,Adult ,medicine.medical_specialty ,PRETERM BIRTH ,Birth weight ,Population ,Gestational Age ,body mass index ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,wa_310 ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Preterm ,Clinical Research ,Humans ,wq_100 ,Obesity ,education ,Obstetrics & Reproductive Medicine ,Metabolic and endocrine ,Nutrition ,business.industry ,Contraception/Reproduction ,Prevention ,preterm birth ,Australia ,Infant ,birth weight ,DIABETES-MELLITUS ,Preterm birth weight gain ,Overweight ,Perinatal Period - Conditions Originating in Perinatal Period ,medicine.disease ,Newborn ,Prevention of disease and conditions ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Good Health and Well Being ,North America ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,pregnancy complication ,business ,Weight gain ,Body mass index ,wb_200 - Abstract
ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain.ConclusionsMaternal pre‐pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre‐pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.Tweetable abstractPromoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.
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- 2019
40. Selenium status during pregnancy and child psychomotor development—Polish Mother and Child Cohort study
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Anna Król, Wojciech Hanke, Gemma Calamandrei, Kinga Polańska, Wojciech Sobala, Renata Brodzka, Flavia Chiarotti, Wojciech Wasowicz, and Jolanta Gromadzinska
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Adult ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Mothers ,Poison control ,010501 environmental sciences ,Language Development ,01 natural sciences ,Bayley Scales of Infant Development ,Cohort Studies ,Selenium ,03 medical and health sciences ,Child Development ,Pregnancy ,Birth Weight ,Humans ,Medicine ,Toddler ,0105 earth and related environmental sciences ,Psychomotor learning ,Population Study ,business.industry ,Spectrophotometry, Atomic ,Infant ,Environmental Exposure ,Maternal Nutritional Physiological Phenomena ,Environmental exposure ,Fetal Blood ,medicine.disease ,030104 developmental biology ,Prenatal Exposure Delayed Effects ,Pediatrics, Perinatology and Child Health ,Cohort ,Female ,Poland ,business ,Psychomotor Performance ,Maternal Age ,Cohort study - Abstract
BACKGROUND: The studies on the impact of selenium (Se) levels in different pregnancy periods on child psychomotor functions are limited. The aim of this study was to evaluate the impact of prenatal Se on child neurodevelopment. METHODS: The study population consisted of 410 mother-child pairs from Polish Mother and Child Cohort. Se levels were measured in each trimester of pregnancy, at delivery, and in cord blood by graphite furnace atomic absorption spectrometry. Psychomotor development was assessed in children at the age of 1 and 2 y using the Bayley Scales of Infant and Toddler Development. RESULTS: Plasma Se levels decreased through pregnancy (from 48.3 ± 10.6 µg/l in the first trimester to 38.4 ± 11.8 µg/l at delivery; P < 0.05). A statistically significant positive association between Se levels in the first trimester of pregnancy and motor development (β = 0.2, P = 0.002) at 1 y of age, and language development (β = 0.2, P = 0.03) at 2 y of age was observed. The positive effect of Se levels on cognitive score at 2 y of age was of borderline significance (β = 0.2, P = 0.05). CONCLUSION: Prenatal selenium status was associated with child psychomotor abilities within the first years of life. Further epidemiological and preclinical studies are needed to confirm the association and elucidate the underlying mechanisms of these effects.
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- 2016
41. Good practice in occupational health services – The influence of hazardous conditions and nuisance coexisting in the work environment and at home on the course and outcome of pregnancy
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Teresa Makowiec-Dąbrowska, Paweł Muszyński, Marta Wiszniewska, Andrzej Marcinkiewicz, Jolanta Walusiak-Skorupa, Wojciech Hanke, Agata Wężyk, Kinga Polańska, and Nofer Institute of Occupational Medicine, Lodz, Poland
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occupational hazards ,medicine.medical_specialty ,Occupational Health Services ,Household chores ,Occupational health service ,psychological factors ,Risk Assessment ,occupational health service ,Psychological factors ,Occupational safety and health ,Occupational medicine ,Nursing ,Risk Factors ,Pregnancy ,medicine ,Humans ,Preventive healthcare ,Occupational health ,household chores ,business.industry ,lcsh:Public aspects of medicine ,Occupational hazards ,Public Health, Environmental and Occupational Health ,Human factors and ergonomics ,lcsh:RA1-1270 ,General Medicine ,Working time ,Pregnancy Complications ,Work (electrical) ,Accidents, Home ,occupational health ,Accidental Falls ,Female ,Pregnant Women ,pregnancy ,Occupational stress ,business ,Risk assessment ,Women, Working - Abstract
The key activity in good practice of occupational medicine is to control, on a regular basis, the workers' health and how it is affected by the work environment and - consequently - to provide the employers and employees with advice regarding the organization, ergonomics, physiology and psychology of work. Occupational medicine practitioners should remember that certain duties are performed both at work and at home. This issue is particularly important in preventive healthcare of pregnant working women. Taking the above into consideration, we reviewed the literature with respect to nuisance and occupational risk factors, which might be associated with professional and household duties. The research indicates the need to reduce activities that require frequent bending or lifting, put a women at risk of falling or cause excess occupational stress for pregnant women. We would like to draw the doctors' attention to the possibility of exceeding a 4-hour limit of work at video display terminals and negative effects of low physical exercise and sitting for a long time both at work and at home. Since long working hours (over 40 h/week) affect the course of pregnancy negatively, total working time at work (including any additional jobs) and at home must be taken into account in the occupational risk assessment. To sum up, we emphasize that preventive healthcare of pregnant working women should mainly include education programmes. Women need to know how to perform their work safely and pay attention to the scope and frequency of household tasks (duties).Kluczowym działaniem w ramach dobrych praktyk w opiece profilaktycznej jest systematyczna kontrola stanu zdrowia pracujących, ocena jego związku przyczynowego z warunkami pracy oraz w efekcie – udzielanie pracownikom i pracodawcom porad w zakresie organizacji pracy, ergonomii, fizjologii i psychologii pracy. Lekarz medycyny pracy powinien przy tym pamiętać, że niektóre czynności wykonywane przez pracowników nie tylko wchodzą w zakres obowiązków zawodowych, ale są wykonywane przez nich również w domu. Taka świadomość jest szczególnie ważna w opiece profilaktycznej nad pracującą ciężarną. Biorąc powyższe pod uwagę, autorzy niniejszej publikacji dokonali przeglądu piśmiennictwa pod kątem uciążliwości i czynników szkodliwych, na które kobiety w ciąży mogą być narażone w trakcie wykonywania pracy zawodowej i w warunkach domowych. Przedstawione wyniki badań wskazują konieczność minimalizowania u ciężarnych czynności wymuszających częste pochylanie się, grożących upadkiem, wymagających dźwigania oraz związanych z nadmiernym stresem. Zwrócono uwagę na możliwość przekraczania łącznie w pracy i w domu obecnie obowiązującego w polskim prawie limitu 4 godzin pracy przy komputerze – głównie ze względu na wiążący się z tym niekorzystny wpływ niskiej aktywności fizycznej i długotrwale utrzymywanej pozycji siedzącej. Ze względu na niekorzystny wpływ pracy powyżej 40 godz. tygodniowo na przebieg ciąży w ocenie ryzyka zawodowego wskazana jest analiza łącznego czasu pracy ciężarnej z uwzględnieniem dodatkowych prac zarobkowych i zajęć domowych. W podsumowaniu autorzy podkreślają, że opieka profilaktyczna nad pracującą ciężarną wymaga edukowania ciężarnych w zakresie sposobu wykonywania obowiązków służbowych, ze zwróceniem uwagi na zakres i częstość czynności domowych analogicznych do zawodowych. Med. Pr. 2015;66(5):713–724.
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- 2015
42. Early childhood allergy symptoms in relation to plasma selenium in pregnant mothers
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Paweł Majak, Daniela Podlecka, Włodzimierz Stelmach, Kinga Polańska, Beata Janasik, Wojciech Hanke, Joanna Jerzyńska, Jolanta Gromadzinska, Iwona Stelmach, and Wojciech Wasowicz
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Adult ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,Allergy ,Immunology ,Mothers ,Selenium ,03 medical and health sciences ,Plasma selenium ,0302 clinical medicine ,Pregnancy ,Hypersensitivity ,Humans ,Immunology and Allergy ,Medicine ,Early childhood ,business.industry ,Infant ,medicine.disease ,030104 developmental biology ,030228 respiratory system ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Female ,business - Published
- 2017
43. Air Pollution Exposure during Pregnancy, Depression/Anxiety Symptoms, and Conduct/Aggressive Problems in Children in Eight European Cohort Studies
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Giulia Cesaroni, Marie Standl, Henning Tiemeier, Małgorzata J. Lubczyńska, Daniela Porta, Michael Jerrett, Ainhoa Jorcano, Remy Slama, Nelly D. Saenen, Carmen Iñiguez, Jordi Sunyer, Carmen Freire, T. Nawrot, Manon H.J. Hillegers, Kinga Polańska, Adonina Tardón, Wojciech Hanke, Jesús Ibarluzea, Gerard Hoek, Dorothee Sugiri, Johanna Lepeule, Mònica Guxens, Bert Brunekreef, Livia Pierotti, and Tania Vrijkotte
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Pregnancy ,business.industry ,Air pollution exposure ,Air pollution ,medicine.disease ,medicine.disease_cause ,Environmental health ,medicine ,General Earth and Planetary Sciences ,Anxiety ,medicine.symptom ,business ,Depression (differential diagnoses) ,General Environmental Science ,Cohort study - Abstract
Background: Exposure to air pollution during pregnancy may increase several behavior problems, including depression/anxiety or conduct/aggressive problems in children, but findings have been incons...
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- 2018
44. Concentrations of Phthalate Metabolites in Children from Poland
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Holger M. Koch, Stephan Bose-O’Reilly, Claudia Pälmke, Kinga Polańska, Wojciech Hanke, and Mercè Garí
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chemistry.chemical_compound ,Chemistry ,Environmental chemistry ,Phthalate ,General Earth and Planetary Sciences ,General Environmental Science - Published
- 2018
45. The Environment-Wide Approach for the Assessment of the Effect of Environmental Stressors on Overweight, Obesity and Diabetes: A Study on Singletons for the Heals Project
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Dimosthenis Sarigiannis, Isabella Annesi-Maesano, Sara Maio, Shreosi Sanyal, Giovanni Viegi, Joan O. Grimalt, Edward Johnstone, Kinga Polańska, Milena Horvat, Elisabete Ramos, Zdravko Špirić, Johnson, Markey, Zidek, Angelika, and Smargiassi, Audrey
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business.industry ,Diabetes mellitus ,Environmental health ,Stressor ,Overweight obesity ,General Earth and Planetary Sciences ,Medicine ,business ,medicine.disease ,Environmental Stressors, Overweight, Obesity and Diabetes ,General Environmental Science - Abstract
One of the main aims of the HEALS project is to unravel, through an exposomic approach, the development of metabolic diseases. The objective of the present study was to investigate the relationship between body burden from endocrine disrupting chemicals (EDCs) exposure (Holtcamp, 2012 ; La Merrill and Birnbaum, 2011) and the onset of overweight, obesity and diabetes, in view to promote preventive actions. Data was obtained from several pre-existing European cohorts (REPRO-PL, PI1, PI2, IMCA, SEASD, CCM, PHIME-CRO, PHIME-SI, G21, EPITeen, EDEN, CHISQ200 and MAAS). They were harmonised and cleaned to obtain a final dataset of 28, 608 individuals. To replace missing values, a multiple imputation methodology was used. The EWAS analysis employed a survey-weighted logistic regression method with a Bonferroni correction to adjust the probability values and counteract the problem of multiple comparisons. As dependent variables, the health outcomes considered were overweight (BMI>=25), obesity (BMI>=30) and type-2 diabetes mellitus. As independent variables, 70 environmental assays and other demographic factors, at different periods of life were included. Obesity was found to be positively and significantly associated with PM10 (OR=1.174, p-value=0.005), NO2 (1.276, 0.030), PCB118 (2.687, 0.026)), zinc (1.098, 0.021) and several class of phthalates like MEHP (1.095, 0.026). A negative association was observed for some stressors like brominated diphenyl ether BDE153 (0.980, 0.001) and cadmium (0.868, 0.001). Comparable results were obtained for overweight and diabetes. Our EWAS analyses confirm potential association between multiple environmental factors and overweight, obesity and diabetes. Whether mechanisms underlying metabolic changes depend on adipocyte proliferation and differentiation, glucose homeostasis, insulin release or behaviour (traffic pollution may also lead to less physical activities and sedentary lifestyle) needs to be further investigated.
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- 2018
46. Phthalate exposure and neurodevelopmental outcomes in early school age children from Poland
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Ewelina Wesołowska, Claudia Pälmke, Aleksander Stańczak, Stephan Bose-O'Reilly, Wojciech Hanke, Małgorzata Waszkowska, Gemma Calamandrei, Holger M. Koch, Mercè Garí, Kinga Polańska, and Agnieszka Jankowska
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Phthalic Acids ,Mothers ,Urine ,Endocrine Disruptors ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Environmental health ,Cognitive development ,Humans ,Medicine ,030212 general & internal medicine ,Child ,Adverse effect ,0105 earth and related environmental sciences ,General Environmental Science ,Psychomotor learning ,business.industry ,Phthalate ,Cognition ,Environmental Exposure ,Strengths and Difficulties Questionnaire ,chemistry ,Neurodevelopmental Disorders ,Cohort ,Environmental Pollutants ,Female ,Poland ,business - Abstract
Some phthalates are known endocrine disrupting chemicals (EDC). They are widely present in the environment thus their impact on children’s health is of particular scientific interest. The aim of the study was to evaluate the association between phthalate exposure and neurodevelopmental outcomes, in particular behavioral, cognitive and psychomotor development, in 250 early school age children from the Polish Mother and Child Cohort (REPRO_PL). Urine samples were collected at the time of children’s neurodevelopmental assessment and were analysed for 21 metabolites of 11 parent phthalates. Behavioral and emotional problems were assessed by the Strengths and Difficulties Questionnaire (SDQ) filled in by the mothers. To assess children’s cognitive and psychomotor development, Polish adaptation of the Intelligence and Development Scales (IDS) was administered. The examination was performed by trained psychologists. Dimethyl phthalate (DMP) and di-n-butyl phthalate (DnBP) were the two phthalates showing the highest statistically significant associations, with higher total difficulties scores (β = 1.5, 95% CI 0.17; 2.7; β = 1.5, 95% CI 0.25; 2.8, respectively) as well as emotional symptoms and hyperactivity/inattention problems for DnBP (β = 0.46, 95% CI -0.024; 0.94; β = 0.72, 95% CI 0.065; 1.4, respectively), and peer relationships problems for DMP (β = 0.37, 95% CI -0.013; 0.76). In addition, DnBP and DMP have been found to be negatively associated with fluid IQ (β = −0.14, 95% CI -0.29; 0.0041) and crystallized IQ (β = −0.16, 95% CI -0.29; −0.025), respectively. In the case of mathematical skills, three phthalates, namely DMP (β = −0.17, 95% CI -0.31; −0.033), DEP (β = −0.16, 95% CI -0.29; −0.018) and DnBP (β = −0.14, 95% CI -0.28; 0.0012), have also shown statistically significant associations. This study indicates that exposure to some phthalates seems to be associated with adverse effects on behavioral and cognitive development of early school age children. Further action including legislation, educational and interventional activities to protect this vulnerable population is still needed.
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- 2019
47. Predictors of E-Cigarette Use Susceptibility—A Study of Young People from a Socio-Economically Disadvantaged Rural Area in Poland
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Kinga Polańska, Mirosław Niedzin, Dorota Kaleta, Agnieszka Jankowska, and Nofer Institute of Occupational Medicine
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Male ,Adolescent ,Health, Toxicology and Mutagenesis ,lcsh:Medicine ,Binge drinking ,Cigarette use ,Electronic Nicotine Delivery Systems ,Vulnerable Populations ,Article ,susceptibility ,Cigarette Smoking ,Odds ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Cigarette smoking ,Humans ,Medicine ,030212 general & internal medicine ,Students ,youth ,Schools ,030505 public health ,business.industry ,Vaping ,lcsh:R ,Public Health, Environmental and Occupational Health ,socially disadvantaged rural area ,e-cigarettes ,Disadvantaged ,predictors ,Cross-Sectional Studies ,Socioeconomic Factors ,Female ,Moderate drinking ,Poland ,Rural area ,0305 other medical science ,business ,Alcohol consumption ,Demography - Abstract
Identification of the youth at risk of e-cigarette use is crucial for development of effective prevention strategies. The current study aims at evaluation of predictors of susceptibility to e-cigarette initiation and experimentation among adolescents. This cross-sectional study included 1693 students (non-current users of e-cigarettes) attending 21 schools in Piotrkowski district (a socially disadvantaged rural area in central Poland). The regression models were applied so as to study factors linked to susceptibility to e-cigarette use among never users (n = 1054) and ever users (n = 639) of e-cigarettes, with susceptibility defined as the absence of a firm decision not to use these products. A high proportion of the youth was susceptible to e-cigarette use (68% of never and 78% of ever e-cigarette users). The adjusted model confirmed the following risk factors: smoking parents and friends (never users: OR = 3.0, p <, 0.001, OR = 2.0, 0.05, ever users: OR = 2.2, OR = 2.2, 0.01), alcohol consumption (never users: moderate drinking OR = 2.9, binge drinking OR = 2.2, 0.01, ever users: moderate drinking OR = 4.2, 0.001), cigarette smoking (never users: OR = 14.1, ever users: OR = 11.3, 0.001), and perception that e-cigarettes are less harmful than traditional cigarettes (never users: OR = 1.8, 0.001). The youth whose mothers had a medium and high educational level (never users: OR = 2.7, OR = 2.7, ever users: OR = 5.4, OR = 4.4, 0.001), those who perceived girls who use e-cigarettes as more attractive (never users: OR = 4.1, ever users: OR = 2.9, 0.01), and secondary school students (ever users: OR = 5.6, 0.001) had higher odds of susceptibility to e-cigarette use. The youth who had more money per month were less susceptible to e-cigarette experimentation (OR = 0.4, 0.001). A multi-level intervention approach, considering vulnerable populations, is required to prevent the youth from e-cigarette initiation and experimentation.
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- 2019
48. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania
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Loreto Santa-Marina, Irina Lehmann, Barbara Heude, Emily Oken, Ellis Voerman, Leanne K. Küpers, Eva Corpeleijn, Marie-France Hivert, Tanja G. M. Vrijkotte, Anne M. Karvonen, Stef van Buuren, Maria Pia Fantini, Camilla Stoltenberg, Daniel O. Hryhorczuk, Johanna Mäkelä, Lorenzo Richiardi, Maria-Jose Lopez-Espinosa, Marleen M.H.J. van Gelder, Costanza Pizzi, Maties Torrent, Davide Gori, Per Magnus, Andrea von Berg, Romy Gaillard, Martine Vrijheid, Vincent W. V. Jaddoe, Lenie van Rossem, Kinga Polańska, Luigi Gagliardi, Henriette A. Smit, Francesco Forastiere, Agnieszka Pac, George P. Chrousos, Renata Majewska, Vagelis Georgiu, Eleni Papadopoulou, Susana Santos, Rae-Chi Huang, Carel Thijs, Suzanne Tough, Henrique Barros, Adriette J. J. M. Oostvogels, Wojciech Hanke, Nathalie Costet, Thorkild I. A. Sørensen, Ellen A. Nohr, Juha Pekkanen, Keith M. Godfrey, Ana Cristina Santos, Anne-Marie Nybo Andersen, Monique Mommers, Sheryl L. Rifas-Shiman, Hazel Inskip, George Moschonis, Marie Standl, Iris Eekhout, Daniela Porta, Leda Chatzi, Cécile Chevrier, Yannis Manios, Debbie A Lawlor, Tomas Trnovec, Camilla Schmidt Morgen, Elisabeth Thiering, Irva Hertz-Picciotto, Merete Eggesbø, Hanna Lagström, Veit Grote, Berthold Koletzko, Nel Roeleveld, Myriam Doyon, John P. Newnham, Sheila McDonald, Marie-Aline Charles, Sarah Crozier, Maggie A. Stanislawski, Oleksandr Zvinchuk, Sara Farchi, Ľubica Palkovičová Murínová, Todd A. Jusko, Pediatrics, Erasmus MC other, Epidemiology, Nofer Institute of Occupational Medicine, Department of Public Health, Clinicum, University of Helsinki, Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Epidemiology and Data Science, APH - Aging & Later Life, Public and occupational health, Graduate School, ARD - Amsterdam Reproduction and Development, APH - Health Behaviors & Chronic Diseases, APH - Methodology, RS: NUTRIM - R3 - Respiratory & Age-related Health, Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Santos, Susana, Eekhout, Iri, Voerman, Elli, Gaillard, Romy, Barros, Henrique, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cécile, Chrousos, George P, Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Doyon, Myriam, Eggesbø, Merete, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Gagliardi, Luigi, Georgiu, Vageli, Godfrey, Keith M, Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hivert, Marie-France, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Jusko, Todd A, Karvonen, Anne M, Koletzko, Berthold, Küpers, Leanne K, Lagström, Hanna, Lawlor, Debbie A, Lehmann, Irina, Lopez-Espinosa, Maria-Jose, Magnus, Per, Majewska, Renata, Mäkelä, Johanna, Manios, Yanni, McDonald, Sheila W, Mommers, Monique, Morgen, Camilla S, Moschonis, George, Murínová, Ľubica, Newnham, John, Nohr, Ellen A, Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriëtte J J M, Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L, Roeleveld, Nel, Santa-Marina, Loreto, Santos, Ana C, Smit, Henriette A, Sørensen, Thorkild I A, Standl, Marie, Stanislawski, Maggie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Matie, Tough, Suzanne C, Trnovec, Toma, van Gelder, Marleen M H J, van Rossem, Lenie, von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja G M, Zvinchuk, Oleksandr, van Buuren, Stef, Jaddoe, Vincent W V, LS IRAS EEPI ME (Milieu epidemiologie), Leerstoel van Buuren, and Methodology and statistics for the behavioural and social sciences
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embarazo ,humanos ,lcsh:Medicine ,Reproductive health and childbirth ,Overweight ,Medical and Health Sciences ,INCREASE ,Body Mass Index ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Pregnancy ,030212 general & internal medicine ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,POPULATION ,Weight Gain ,Charts ,References ,2. Zero hunger ,Pediatric ,Medicine(all) ,education.field_of_study ,OUTCOMES ,030219 obstetrics & reproductive medicine ,CONSTRUCTION ,Obstetrics ,Medicine (all) ,Pregnancy Outcome ,General Medicine ,ASSOCIATION ,adulto ,Pregnancy Complication ,Gestational Weight Gain ,Europe ,Health ,Gestation ,GROWTH ,Female ,medicine.symptom ,Underweight ,Human ,Research Article ,resultado del embarazo ,STANDARDS ,Adult ,medicine.medical_specialty ,Reference ,Oceanía ,Population ,Oceania ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,AGE ,Clinical Research ,General & Internal Medicine ,medicine ,Humans ,factores de riesgo ,complicaciones del embarazo ,Chart ,Obesity ,Conditions Affecting the Embryonic and Fetal Periods ,education ,Metabolic and endocrine ,Weight gain ,Nutrition ,Gestational Weight Gain/physiology ,business.industry ,Risk Factor ,Prevention ,índice de masa corporal ,lcsh:R ,Perinatal Period - Conditions Originating in Perinatal Period ,medicine.disease ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Pregnancy Complications ,PATTERN ,Good Health and Well Being ,3121 General medicine, internal medicine and other clinical medicine ,North America ,business ,Body mass index - Abstract
BackgroundGestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies.MethodsWe used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape.ResultsWe observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40weeks was 14.2kg (11.4-17.4) for underweight women, 14.5kg (11.5-17.7) for normal weight women, 13.9kg (10.1-17.9) for overweight women, and 11.2kg (7.0-15.7), 8.7kg (4.3-13.4) and 6.3kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications.ConclusionsGestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice., ABCDr This work was supported by the Netherlands Organization for Health Research and Development (ZonMw) (TOP grant, 40-00812-98-11010).r ALSPACr The UK Medical Research Council and Wellcome (Grant ref.: 102215/2/13/2) and the University of Bristol provide core support fog ALSPAC. This study has received support from the US National Institute of Health (R01 DK10324) and European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no 669545. DA Lawlor works in a unit that receives UK MRC funding (MQ_UU_12013/5) and is an NIHR senior investigator (NF-Sl-0611-10196).r AOB/Fr All Our Families is funded through Alberta Innovates Interdisciplinary Team Grant 4200700595, the Alberta Children's Hospital Foundation, and the Max Bell Foundation.r DNBCr The Danish National Research Foundation has established the Danish Epidemiology Science Centre that initiated and created the Danish National Birth Cohort. The cohort is furthermore a result of a major grant from this foundation. Additional support for the Danish National Birth Cohort is obtained from the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Augustinus Foundation, and the Health Foundation. The DNBC 7-year follow-up is supported by the Lundbeck Foundation (195/04) and the Danish Medical Research Council (SWF 0646).r EDENr The EDEN Study was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte sante 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs, Paris-Sud LJniversity, Nestle, French National Institute for Population Health Surveil lance (InVS), French National Institute for h-lealth Education (APES), the European Union FP7 programmes (FP7/2007-2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Re.search Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Generale de l'Education Nationale a complementary health inswance (MGEN), French national agency for food security, French-speaking association for the study of diabetes and metabolism (ALFEDIAM).r FCOUr FCOU study is supported by the US National Institutes of Health Fogarty International Center, US NIEHS, US CDC, US PA, and National Academy of Medical Sciences of Ukraine.r GASPIIr Ministry of Health.r GECKO Drenther The GECKO Drenthe birth cohort was funded by an unrestricted grant of Hutchison Whampoa Ld, Hong Kong and supported by the University of Groningen, Well Baby Clinic Foundation Icare, Noodlease, Paediatric Association Of The Netherlands and Youth Health Care Drenthe.r Generation Rr The general design of the Generation R Study is made possible by financial support from the Erasmus MC, University Medical Center, Rotterdam, Erasmus University Rotterdam, Netherlands Organization for Health Research and Development (ZonMw), Netherlands Organisation for Scientific Research (NWO), Ministry of Health, Welfare and Sport and Ministry of Youth and Families. Research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013), project ErlyNutrition under grant agreement no. 289346, the European Union's Horizon 2020 research and innovation programme under grant agreement no.; 633595 (DynalHEALTH)and the European Union's Horzon 2020 research and Innovation programme under grant agreement 733206 (LifeCycle Project). Romy Gaillard received funding from the Dutch Heart Foundation (grant number 2017T013) and the Dutch Diabetes Foundation (grant number 2017.81.002). Vincent Jaddoe received grants from the Netherlands Organization for Health Research and Development (VIDI 016.136.361) and the European Research Council (Consolidator Grant, ERC-2014-CoG-648916).r Generation XXIr Generation XX: was funded by Pmgrama Operational de Saude-Saude XXI, Quadro Comunitario de Apoio III and Administracao Regional de Saude Norte (Regional Department of Ministry of Health). This study was funded by FEDER through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology FCT (Portuguese Minstry of Science, Technology and Higher Education) (POCI-01-0145-FEDER-016837), under the project PathMOB.: Risco cardiomwtabolico na infancia: desde o inicio da vida ao fim da infancia (Ref. FCT PIDc/DTP-EP1/3306/2014) and the Unidade de Investigacao em Epiclemiologia-Instituto de Saude Publica da Universidade do Porte (EPIUnit) (POCI-01-0145-FEDER-006862; Ref. UlD/DTP/04750/2013). AC Santos holds a FG Investigator contract IF/01060/2015.r GENESISr The study was supported by a research grant from Friesland Foods Hellas. Gen3G Gen3G was supported by a Fonds de recherche du Quebec en sante (FRQ-S) operating grant (grant 4206971; a Canadian Institute of Health Reseach (CIHR) Operating grant (grant WOE) 115071); a Diabete Quebec grant and a Canadian Diabetes Association operating grant (grant #OG-3-08-2622-JA).r GINIplusr The GINIplus study was mainly supported for the first 3 years of the Federal Ministry for Education, Science, Research and Technology I:interventional arm) and Helmholtz Zentrum Munich (former GSF) (observational arm). The 4-year, 6-year, 10-year, and 15-year follow-up examinations of the GINIplus Study were covered from the respective budgets of the 5 study centers Helmoltz Zentrum Munich (former GSF), Research Institute at Marien-Hospital Wesel, LMU Munich, TU Munich and from 6 years onwards also from IUF-Leibniz Research-Institute for Environmental Medicine at the University of Dusseldorp and a grant from the Federal Ministry for Environment (IUF Dus seldoit FKZ 20462296). Further, the 15 year follow-up examination of the GINIplus study was supported by the Commission of the European Communities, the 7th Framework Program: MeDALL project, and as well by the companies Mead Johnson and Nestle.r HUMISr European Community's Seventh Framework Programme (P7/2007-2013) under grant agreements Early Nutrition no. 289346 and by funds from the Norwegian Research Council's MILPAAHEL programme, project no. 213148. INMA-Sabadellr This study was funded by grants from the Institute de Salad Carlos III (Red INMA G03/176) and the Genera tat de Catalunya-CIRIT (1999SGR 00241).r INMA-Valenciar This study was funded by Grants from UE (P7-ENV-2011 cod 282957 and HEALTH2010.2.4.5-1), Spain: ISCIII (G03/176; FIS-FEDER: P109/02647, PI11/01007, PI11/02591, PI11/02038, PI1.3/1944-, PI13/2032, P114/00891, PI14/01687, and PI16/1288; Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051), and Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249).r INMA-Gipuzkoar This study was funded by grants from the Institute. de Salad Carlos III (Red INMA G03/176).; r KOALAr Data collection for the KOALA study from pregnancy up to age 1 year was financially supported by grants from Royal Friesland Foods (Leeuwarden); Trio dos Foundation (Zeist); Phoenix Foundation; Raphael Foundation; Iona Foundation, Foundation for the Advancement of Heilpedagogie (all in the Netherlands).r Krakow Cohortr The study received funding from a NIEHS R01 grants entitled: Vulnerability of the Fetus/Infant to PAH, PM2.5 and FTS and Developmental effects of early-life exposure to airborne PAC (R01ES010165 and R01ES015282) and from The Lundin Foundation, The John and Wendy Neu Family Foundation, The Gladys and Roland Harriman Foundation and an Anonymous Foundation.r LISAplusr The LISAplus study was mainly supported by grants from the Federal Ministry for Education Science, Research and Technology and in addition from Helmholtz Zentrum Munich (former GSF), Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel, Pediatric Practice, Bad Honnef for the first 2 years. The 4-year, 6-year, 10-year, and 15-year follow-up examinations of the LISA-plus Study were covered from the respective budgets of the involved partners (Helmholtz Zentrum Munich (former GSF), Helmholtz Centre for Enironmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel Pediatric Practice, Bad Honnef, IUr-Leibniz-Research Institute for Environmental Medicine at the University of Dusseldorf) and in addition by a grant from the Federal Ministry for Environment (IUF-Dussedorf, FKZ 204622961. Further, the 15-year follow-up examination of the LISAplus study was supported by the Commission of the FaMpean Communities and the 7th Framework Program: McDALL project.r LUKAS The grants from the Academy of Finland (grants 139021;287675); the Juho Vainio Foundation; the Foundation for Pediatric Research; EVE/VTR-funding; Paivikki and Saran Sohlberg Foundation; The Finnish Cultural Foundation; European Union QLK4-CT-2001-00250; and by the National Institute for Health and Welfare, Finland.r MoBar The Norwegian Mother and Child Cohort Study is supported by the Norwegian [Ministry of Health and Care. Services and the Ministry of Education and Research, NIH/NIEHS (contract no. N01-ES-75558), NIH/NINDS (grant. no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1).r NINFEAr The NINFEA cohort was partially funded by the Compagnia San Paolo Fundation and by the Piedmont Region.r PELAGIEr The Pelagic cohort was supported by the French National Research Agency (ANR-2010-PRSP-007) and the French Research Institute for Public Health (AMC11004NSA-DGS).r PIAMAr The PIAMA study was supported by the Netherlands Organization for Health Research and Development; The Netherlands Organization for Scientific Research; The Netherlands Asthma Fund; The Netherlands Ministry of Spatial Planning, Housing, and the Environment; and The Netherlands Ministry of Health, Welfare, and Sport.r Piccolipiur The Piccolipiu project was financially supported by the Italian National Center for Disease Prevention and Control (CCM grants years 2010 and 2014) and by the Italian Ministry of Health (art 12 and 12 bis D.Igs 502/92).r PRIDE Studyr The PRIDE Study is supported by grants from the Netherlands Organization for Health Research and Development, the Radboud Institute for Health Sciences, and the Lung Foundation Netherlands.r Project Vivar National Institutes of Health (R01 HD034568, UGOD023286).; r RAINE Studyr The Western Australian Pregnancy Cohort (Raine Study) has been funded by program and project grants from the Australian National Health and Medical Research Council, the Commonwealth Scientific and Industrial Research Organization, Healthway, and the Lions Eye Institute in Western Australia. The University of Western Australia (UWA), Curtin University, the Raine Medical Research Foundation, the Telethon Kids Institute, the Women's and Infant's Research Foundation (KEMH), Murdoch University, The University of Notre Dame Australia, and Edith Cowan University provide funding for the Core Management of the Raine Study.r REPRO_PLr National Science Centre, Poland, under the grant DEC-2014/15/3/NZ7/00998, FP7 HEALS Grant No. 603946 and the Ministry of Science and Higher Education, under grant agreement no. 3068/7.PR./2014/2.r RHEAr The Rhea project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP&.STREP Hiwate, EU FP7 ENV.2007.1222 Project No. 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No. 226285 ENIIIECO, EU-FP/-HEALTH-2012 Proposal No 308333 HELIX) and the Greer: Ministry of Health (Program of Prevention of obesity and ileuMdevelopmental disorders in preschool children, in Heraklion District, Crete, Greece: 2011-2014; Rhea Plus: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health 2012-15).r Slovak PCB studyr Support was provided by US National Institutes of Health grants R01 CA096525, R03 TW007152, P30 E5001247, and K12 ES019852.r STEPSr This study was supported by the University of Turku, Abo Akademi University, the Turku University Hospital, and the City of Turku, as well as by the Academy of Finland (grants 121569 and 123571), the Juno Vainio Foundation, the Yrjo Jahnsson Foundation, the TorKu.r SWSr The SWS is supported by grants from the Medical Research Council, National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, and the European Union's Seventh Framework Programme. (P7/2007-2013), project EarlyNutrifion (grant 289346). Study participants were drawn from a cohort study funded by the Medical Research council and the Dunhill Medical Trust.
- Published
- 2018
49. Maternal Stress During Pregnancy and Allergic Diseases in Children During the First Year of Life
- Author
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Iwona Stelmach, Dorota Merecz-Kot, Anna Król, Włodzimierz Stelmach, Paweł Majak, Joanna Jerzyńska, Katarzyna Smejda, Wojciech Hanke, Kinga Polańska, and Nofer Institute of Occupational Medicine
- Subjects
Hypersensitivity, Immediate ,Male ,Pediatrics ,Perceived Stress Scale ,Critical Care and Intensive Care Medicine ,Cohort Studies ,0302 clinical medicine ,Pregnancy ,Surveys and Questionnaires ,030212 general & internal medicine ,Respiratory Tract Infections ,atopic dermatitis ,Respiratory tract infections ,medicine.diagnostic_test ,General Medicine ,Holmes and Rahe stress scale ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Cohort ,Female ,Food Hypersensitivity ,Cohort study ,Pulmonary and Respiratory Medicine ,Adult ,medicine.medical_specialty ,recurrent respiratory tract infections ,Dermatitis, Atopic ,03 medical and health sciences ,children ,medicine ,Humans ,Respiratory sounds ,Respiratory Sounds ,food allergy ,wheezing ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Pregnancy Complications ,Logistic Models ,030228 respiratory system ,Prenatal stress ,maternal stress ,Multivariate Analysis ,Poland ,business ,Stress, Psychological - Abstract
BACKGROUND: Many recent studies indicate that prenatal maternal distress increases the risk of allergic diseases in children. The mechanisms that favor it are still unclear. OBJECTIVES: We aimed to assess the association between exposure to different kinds of prenatal stress and the occurrence of atopic dermatitis, food allergy, wheezing, and recurrent respiratory tract infections in children. METHODS: The study population consisted of 370 mother–child pairs from a Polish Mother and Child Cohort (REPRO_PL). The analysis was restricted to the women who worked at least one month during the pregnancy period. Maternal psychological stress during pregnancy was assessed based on the Subjective Work Characteristics Questionnaire, the Perceived Stress Scale, and the Social Readjustment Rating Scale. The presence of atopic dermatitis, food allergy, wheezing, and recurrent respiratory tract infections in children was evaluated by doctors at 12 months of age. RESULTS: In a univariate model, we showed significant association between maternal life stress (according to the Perceived Stress Scale) and stressful life events (according to the Social Readjustment Rating Scale) and infant wheezing (at least 1 episode of wheezing during the first year of life). A multivariate model of logistic regression analysis revealed that maternal stress during pregnancy, described by the Social Readjustment Rating Scale, increased the risk of wheezing in children (OR 1.09, 95% CI 1.01–1.02) independently from other predictors of wheezing previously determined in this cohort, such as the number of infections and maternal smoking. We observed also significant positive association between maternal life stress during pregnancy measured by the Perceived Stress Scale and the risk of recurrent respiratory tract infections in the first year of life, however it was not significant after adjustment for confounding variables. CONCLUSIONS: Maternal stress during pregnancy increases the risk of childhood wheezing. The effects of stress during pregnancy on the onset of allergic diseases in children should be developed and translated into early prevention strategies.
- Published
- 2017
50. Micronutrients during pregnancy and child psychomotor development: Opposite effects of Zinc and Selenium
- Author
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Anna Król, Fiorino Mirabella, Gemma Calamandrei, Renata Kuras, Jolanta Gromadzinska, Wojciech Wasowicz, Beata Janasik, Flavia Chiarotti, Wojciech Hanke, and Kinga Polańska
- Subjects
0301 basic medicine ,Male ,Pediatrics ,medicine.medical_specialty ,Physiology ,Child neuropsychological development ,010501 environmental sciences ,01 natural sciences ,Biochemistry ,Bayley Scales of Infant Development ,03 medical and health sciences ,Selenium ,Child Development ,Pregnancy ,Medicine ,Humans ,Micronutrients ,Prospective Studies ,Toddler ,0105 earth and related environmental sciences ,General Environmental Science ,Psychomotor learning ,business.industry ,Infant ,Micronutrient ,medicine.disease ,Fetal Blood ,Child development ,Zinc ,030104 developmental biology ,Maternal Exposure ,Child, Preschool ,Cohort ,Population study ,Female ,Poland ,business ,Prenatal period ,Psychomotor Performance ,Copper - Abstract
Studies on the impact of micronutrient levels during different pregnancy periods on child psychomotor functions are limited. The aim of this study was to evaluate the association between maternal plasma concentrations of selected micronutrients, such as: copper (Cu), zinc (Zn), selenium (Se), and child neuropsychological development. The study population consisted of 539 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL). The micronutrient levels were measured in each trimester of pregnancy, at delivery and in the cord blood. Psychomotor development was assessed in children at the age of 1 and 2 years using the Bayley Scales of Infant and Toddler Development. The mean plasma Zn, Cu and Se concentrations in the 1st trimester of pregnancy were 0.91±0.27mg/l, 1.98±0.57mg/l and 48.35±10.54μg/l, respectively. There were no statistically significant associations between Cu levels and any of the analyzed domains of child development. A positive association was observed between Se level in the 1st trimester of pregnancy and child language and motor skills (β=0.18, p=0.03 and β=0.25, p=0.005, respectively) at one year of age. Motor score among one-year-old children decreased along with increasing Zn levels in the 1st trimester of pregnancy and in the cord blood (β=-12.07, p=0.003 and β=-6.51, p=0.03, respectively). A similar pattern was observed for the association between Zn level in the 1st trimester of pregnancy and language abilities at one year of age (β=-7.37, p=0.05). Prenatal Zn and Se status was associated with lower and higher child psychomotor abilities, respectively, within the first year of life. Further epidemiological and preclinical studies are necessary to confirm the associations between micronutrient levels and child development as well as to elucidate the underlying mechanisms of their effects.
- Published
- 2017
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