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Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

Authors :
Eleni Papadopoulou
Andrea von Berg
Camilla Stoltenberg
Luca Ronfani
Romy Gaillard
Marie Standl
Martine Vrijheid
Sheila McDonald
Yannis Manios
Anne M. Karvonen
Marie-Aline Charles
George P. Chrousos
Daniela Porta
Anne-Marie Nybo Andersen
Keith M. Godfrey
Carol Ní Chaoimh
Costanza Pizzi
Marleen M.H.J. van Gelder
Lawrence J. Beilin
Ana Cristina Santos
Camilla Schmidt Morgen
Monique Mommers
Hazel Inskip
Alet H. Wijga
Per Magnus
Marie-France Hivert
Nel Roeleveld
Lenie van Rossem
Tanja G. M. Vrijkotte
Barbara Heude
Jane West
Steve Turner
Myriam Doyon
Thorkild I. A. Sørensen
Adriëtte J J M Oostvogels
Carel Thijs
Erik Melén
Merete Eggesbø
Maties Torrent
Irina Lehmann
Davide Gori
Susana Santos
Emily Oken
Berthold Koletzko
Ellis Voerman
John Wright
Agnieszka Pac
Pilar Amiano
Sarah Crozier
John Mehegan
Hein Stigum
Louise C. Kenny
Vincent W. V. Jaddoe
Deirdre M. Murray
Debbie A Lawlor
Francesco Forastiere
Johanna Mäkelä
Lorenzo Richiardi
Anna Bergström
Fionnuala M. McAuliffe
Elisabeth Thiering
Nathalie Costet
Hanna Lagström
Juha Pekkanen
Sheryl L. Rifas-Shiman
George Moschonis
Renata Majewska
Kinga Polańska
Rae-Chi Huang
Graham Devereux
Veit Grote
Leanne K. Küpers
Irva Hertz-Picciotto
Eva Corpeleijn
Ellen A. Nohr
Leda Chatzi
Olga Costa
Oleksandr Zvinchuk
Sara Farchi
Cécile Chevrier
Vagelis Georgiu
Tomas Trnovec
Henrique Barros
Maria Pia Fantini
Suzanne Tough
Wojciech Hanke
Daniel O. Hryhorczuk
Pediatrics
Erasmus MC other
Epidemiology
Reproductive Origins of Adult Health and Disease (ROAHD)
Lifestyle Medicine (LM)
Complexe Genetica
RS: NUTRIM - R3 - Respiratory & Age-related Health
Epidemiologie
RS: CAPHRI - R5 - Optimising Patient Care
ARD - Amsterdam Reproduction and Development
APH - Health Behaviors & Chronic Diseases
APH - Aging & Later Life
Public and occupational health
APH - Methodology
Erasmus University Medical Center [Rotterdam] (Erasmus MC)
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153))
Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)
Keck School of Medicine [Los Angeles]
University of Southern California (USC)
Institut de recherche en santé, environnement et travail (Irset)
Université d'Angers (UA)-Université de Rennes 1 (UR1)
Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Azienda Sanitaria Locale [ROMA] (ASL)
Norwegian Institute of Public Health [Oslo] (NIPH)
Santos, Susana
Voerman, Elli
Amiano, Pilar
Barros, Henrique
Beilin, Lawrence J
Bergström, Anna
Charles, Marie-Aline
Chatzi, Leda
Chevrier, Cécile
Chrousos, George P
Corpeleijn, Eva
Costa, Olga
Costet, Nathalie
Crozier, Sarah
Devereux, Graham
Doyon, Myriam
Eggesbø, Merete
Fantini, Maria Pia
Farchi, Sara
Forastiere, Francesco
Georgiu, Vageli
Godfrey, Keith M
Gori, Davide
Grote, Veit
Hanke, Wojciech
Hertz-Picciotto, Irva
Heude, Barbara
Hivert, Marie-France
Hryhorczuk, Daniel
Huang, Rae-Chi
Inskip, Hazel
Karvonen, Anne M
Kenny, Louise C
Koletzko, Berthold
Küpers, Leanne K
Lagström, Hanna
Lehmann, Irina
Magnus, Per
Majewska, Renata
Mäkelä, Johanna
Manios, Yanni
McAuliffe, Fionnuala M
McDonald, Sheila W
Mehegan, John
Melén, Erik
Mommers, Monique
Morgen, Camilla S
Moschonis, George
Murray, Deirdre
Chaoimh, Carol Ní
Nohr, Ellen A
Nybo Andersen, Anne-Marie
Oken, Emily
Oostvogels, Adriëtte J J M
Pac, Agnieszka
Papadopoulou, Eleni
Pekkanen, Juha
Pizzi, Costanza
Polanska, Kinga
Porta, Daniela
Richiardi, Lorenzo
Rifas-Shiman, Sheryl L
Roeleveld, Nel
Ronfani, Luca
Santos, Ana C
Standl, Marie
Stigum, Hein
Stoltenberg, Camilla
Thiering, Elisabeth
Thijs, Carel
Torrent, Matie
Tough, Suzanne C
Trnovec, Toma
Turner, Steve
van Gelder, Marleen M H J
van Rossem, Lenie
von Berg, Andrea
Vrijheid, Martine
Vrijkotte, Tanja G M
West, Jane
Wijga, Alet H
Wright, John
Zvinchuk, Oleksandr
Sørensen, Thorkild I A
Lawlor, Debbie A
Gaillard, Romy
Jaddoe, Vincent W V
Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Department of Public Health
University of Helsinki
Source :
Bjog-An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley-Blackwell Publishing Ltd, BJOG : An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley, BJOG 126, 984-995 (2019), Bjog-an International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley, BJOG: An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley-Blackwell, BJOG: An International Journal of Obstetrics and Gynaecology 126 (2019) 8, BJOG: An International Journal of Obstetrics and Gynaecology, BJOG: An International Journal of Obstetrics and Gynaecology, Wiley, 2019, 126 (8), pp.984-995. ⟨10.1111/1471-0528.15661⟩, Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, L J, Bergstrom, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, G P, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbo, M, Fantini, M P, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, K M, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, M-F, Hryhorczuk, D, Huang, R-C, Inskip, H, Karvonen, A M, Kenny, L C, Koletzko, B, Kupers, L K, Lagstrom, H, Lehmann, I, Magnus, P, Majewska, R, Makela, J, Manios, Y, McAuliffe, F M, McDonald, S W, Mehegan, J, Melen, E, Mommers, M, Morgen, C S, Moschonis, G, Murray, D, Ni Chaoimh, C, Nohr, E A, Andersen, A-M N, Oken, E, Oostvogels, A J J M, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, S L, Roeleveld, N, Ronfani, L, Santos, A C, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, S C, Trnovec, T, Turner, S, van Gelder, M M H J, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, T G M, West, J, Wijga, A H, Wright, J, Zvinchuk, O, Sørensen, T I A, Lawlor, D A, Gaillard, R & Jaddoe, V W V 2019, ' Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts ', B J O G, vol. 126, no. 8, pp. 984-995 . https://doi.org/10.1111/1471-0528.15661, BJOG : an International Journal of Obstetrics and Gynaecology, 126, 984-995, Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, L J, Bergström, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, G P, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbø, M, Fantini, M P, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, K M, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, M-F, Hryhorczuk, D, Huang, R-C, Inskip, H, Karvonen, A M, Kenny, L C, Koletzko, B, Küpers, L K, Lagström, H, Lehmann, I, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McAuliffe, F M, McDonald, S W, Mehegan, J, Melén, E, Mommers, M, Morgen, C S, Moschonis, G, Murray, D, Chaoimh, C N, Nohr, E A, Nybo Andersen, A-M, Oken, E, Oostvogels, A J J M, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, S L, Roeleveld, N, Ronfani, L, Santos, A C, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, S C, Trnovec, T, Turner, S, van Gelder, M M H J, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, T G M, West, J, Wijga, A H, Wright, J, Zvinchuk, O, Sørensen, T I A, Lawlor, D A, Gaillard, R & Jaddoe, V W V 2019, ' Impact of maternal body mass index and gestational weight gain on pregnancy complications : An individual participant data meta-analysis of European, North American and Australian cohorts ', B J O G, vol. 126, no. 8, pp. 984-995 . https://doi.org/10.1111/1471-0528.15661, BJOG: An International Journal of Obstetrics & Gynaecology, BJOG: An International Journal of Obstetrics and Gynaecology, 126(8), 984-995, BJOG : an International Journal of Obstetrics and Gynaecology, 126, 8, pp. 984-995, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, r-FISABIO. Repositorio Institucional de Producción Científica, instname, BJOG : an international journal of obstetrics and gynaecology, vol 126, iss 8, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), BJOG: An International Journal of Obstetrics and Gynaecology, 2019, 126 (8), pp.984-995. ⟨10.1111/1471-0528.15661⟩, BJOG: an International Journal of Obstetrics and Gynaecology
Publication Year :
2019

Abstract

ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain.ConclusionsMaternal pre‐pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre‐pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.Tweetable abstractPromoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.

Subjects

Subjects :
Gestational hypertension
and promotion of well-being
Nutrition and Disease
Birthweight
Reproductive health and childbirth
Low Birth Weight and Health of the Newborn
Cardiovascular
Medical and Health Sciences
DISEASE
Cohort Studies
0302 clinical medicine
3123 Gynaecology and paediatrics
Risk Factors
Pregnancy
Voeding en Ziekte
Infant Mortality
Odds Ratio
Medicine
Birth Weight
2.1 Biological and endogenous factors
EPIDEMIOLOGY
wq_200
Aetiology
2. Zero hunger
Pediatric
RISK
education.field_of_study
OUTCOMES
030219 obstetrics & reproductive medicine
Obstetrics
pregnancy complications
Diabetes
Obstetrics and Gynecology
Gestational age
weight gain
ASSOCIATION
Gestational Weight Gain
Gestational diabetes
Europe
Body Mass Index
Pregnancy Complications
Preterm Birth
Weight Gain
OBESITY
Female
medicine.symptom
Adult
medicine.medical_specialty
PRETERM BIRTH
Birth weight
Population
Gestational Age
body mass index
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
wa_310
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Preterm
Clinical Research
Humans
wq_100
Obesity
education
Obstetrics & Reproductive Medicine
Metabolic and endocrine
Nutrition
business.industry
Contraception/Reproduction
Prevention
preterm birth
Australia
Infant
birth weight
DIABETES-MELLITUS
Preterm birth weight gain
Overweight
Perinatal Period - Conditions Originating in Perinatal Period
medicine.disease
Newborn
Prevention of disease and conditions
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
Good Health and Well Being
North America
3.1 Primary prevention interventions to modify behaviours or promote wellbeing
pregnancy complication
business
Weight gain
Body mass index
wb_200

Details

ISSN :
14700328 and 14710528
Database :
OpenAIRE
Journal :
Bjog-An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley-Blackwell Publishing Ltd, BJOG : An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley, BJOG 126, 984-995 (2019), Bjog-an International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley, BJOG: An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. Wiley-Blackwell, BJOG: An International Journal of Obstetrics and Gynaecology 126 (2019) 8, BJOG: An International Journal of Obstetrics and Gynaecology, BJOG: An International Journal of Obstetrics and Gynaecology, Wiley, 2019, 126 (8), pp.984-995. ⟨10.1111/1471-0528.15661⟩, Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, L J, Bergstrom, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, G P, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbo, M, Fantini, M P, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, K M, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, M-F, Hryhorczuk, D, Huang, R-C, Inskip, H, Karvonen, A M, Kenny, L C, Koletzko, B, Kupers, L K, Lagstrom, H, Lehmann, I, Magnus, P, Majewska, R, Makela, J, Manios, Y, McAuliffe, F M, McDonald, S W, Mehegan, J, Melen, E, Mommers, M, Morgen, C S, Moschonis, G, Murray, D, Ni Chaoimh, C, Nohr, E A, Andersen, A-M N, Oken, E, Oostvogels, A J J M, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, S L, Roeleveld, N, Ronfani, L, Santos, A C, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, S C, Trnovec, T, Turner, S, van Gelder, M M H J, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, T G M, West, J, Wijga, A H, Wright, J, Zvinchuk, O, Sørensen, T I A, Lawlor, D A, Gaillard, R & Jaddoe, V W V 2019, ' Impact of maternal body mass index and gestational weight gain on pregnancy complications : an individual participant data meta-analysis of European, North American and Australian cohorts ', B J O G, vol. 126, no. 8, pp. 984-995 . https://doi.org/10.1111/1471-0528.15661, BJOG : an International Journal of Obstetrics and Gynaecology, 126, 984-995, Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, L J, Bergström, A, Charles, M-A, Chatzi, L, Chevrier, C, Chrousos, G P, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbø, M, Fantini, M P, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, K M, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, M-F, Hryhorczuk, D, Huang, R-C, Inskip, H, Karvonen, A M, Kenny, L C, Koletzko, B, Küpers, L K, Lagström, H, Lehmann, I, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McAuliffe, F M, McDonald, S W, Mehegan, J, Melén, E, Mommers, M, Morgen, C S, Moschonis, G, Murray, D, Chaoimh, C N, Nohr, E A, Nybo Andersen, A-M, Oken, E, Oostvogels, A J J M, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, S L, Roeleveld, N, Ronfani, L, Santos, A C, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, S C, Trnovec, T, Turner, S, van Gelder, M M H J, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, T G M, West, J, Wijga, A H, Wright, J, Zvinchuk, O, Sørensen, T I A, Lawlor, D A, Gaillard, R & Jaddoe, V W V 2019, ' Impact of maternal body mass index and gestational weight gain on pregnancy complications : An individual participant data meta-analysis of European, North American and Australian cohorts ', B J O G, vol. 126, no. 8, pp. 984-995 . https://doi.org/10.1111/1471-0528.15661, BJOG: An International Journal of Obstetrics & Gynaecology, BJOG: An International Journal of Obstetrics and Gynaecology, 126(8), 984-995, BJOG : an International Journal of Obstetrics and Gynaecology, 126, 8, pp. 984-995, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, r-FISABIO. Repositorio Institucional de Producción Científica, instname, BJOG : an international journal of obstetrics and gynaecology, vol 126, iss 8, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), BJOG: An International Journal of Obstetrics and Gynaecology, 2019, 126 (8), pp.984-995. ⟨10.1111/1471-0528.15661⟩, BJOG: an International Journal of Obstetrics and Gynaecology
Accession number :
edsair.doi.dedup.....204876733847c1c1939dc9a1dcb16acd