30 results on '"Katrin Karpinski"'
Search Results
2. Patellarsehnenruptur
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Wolf Petersen, Julia Ohde, Katrin Karpinski, Sebastian Bierke, Martin Häner, and Karl Braun
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- 2022
3. Genu valgum bei vorzeitigem Verschluss der lateralen femoralen Epiphysenfuge bei Z. n. elastisch stabiler intramedullärer Nagelung (ESIN)
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Wolf Petersen, Sebastian Bierke, Julia Ohde, Katrin Karpinski, and Martin Häner
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- 2022
4. Different expectations of patients and surgeons with regard to rotator cuff repair
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Katrin Karpinski, Fabian Plachel, Christian Gerhardt, Tim Saier, Mark Tauber, Alexander Auffarth, Doruk Akgün, and Philipp Moroder
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Surgeons ,Arthroscopy ,Motivation ,Rotator Cuff ,Treatment Outcome ,Quality of Life ,Humans ,Pain ,Orthopedics and Sports Medicine ,Surgery ,General Medicine ,Range of Motion, Articular ,Rotator Cuff Injuries - Abstract
Rotator cuff lesions are a common shoulder pathology mainly affecting patients aged50 years. This condition is accompanied by not only pain and loss of function but also impaired quality of life and psychological stress. A frequently employed treatment option is arthroscopic repair. But expectations regarding the outcome after surgery might differ between patients and surgeons and therefore lead to dissatisfaction on both sides. The aim of this study was to document patient expectations of a planned arthroscopic rotator cuff repair and compare the results with the assessment of shoulder surgeons.A total of 303 patients and 25 surgeons were involved in this study. Patients with partial- or full-thickness tear of the rotator cuff scheduled for arthroscopic repair were included in this study. Preoperatively, they were asked to fill out questionnaires inquiring sociodemographic data, scores of the underlying pathology, as well as expectations regarding the operation with regard to pain relief, gain of range of motion and strength, as well as the effect on activities of daily life, work, and sports. Furthermore, 25 surgeons were surveyed on what they think their patients expected using the same standardized questions.Among the patients, 43.9% considered gain of range of motion to be the most important goal after rotator cuff repair, followed by pain relief (30.6%) and gain of force (13.7%). Among the surgeons, 72% believed pain relief to be the most important for their patient followed by movement (20%) and strength (8%). When asked which parameter was the most important to achieve after operation, for patients, movement was on first place, pain second, and strength third. For shoulder specialists, the ranking was pain, movement, and strength. Surgeons significantly overrated pain relief when ranking against movement compared with their patients.The expectations of patients regarding their operation differ from the surgeon's assessment. Whereas gaining range of motion was more important for patients, surgeons clearly voted for pain relief. Different expectations should therefore be discussed within the pretreatment interview and taken into account when planning the right therapy. This might lead to better satisfaction on both sides.
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- 2022
5. Etiology of posterior meniscus root tears: medial vs. lateral
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Katrin Karpinski, Philipp Forkel, Martin Häner, Sebastian Bierke, and Wolf Petersen
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Orthopedics and Sports Medicine ,Surgery ,General Medicine - Abstract
The aim of this study was to generate more information on the etiology and pathogenesis of medial (MM) and lateral (LM) meniscus root tears. Our hypothesis was that root tears of the MM predominantly result from degenerative damage, whereas root injuries of the LM are mainly of traumatic origin.Consecutively, 53 patients with a root tear of the medial meniscus (MMRT) and 51 patients with a root tear of the lateral meniscus (LMRT) were included in this study. The diagnosis was confirmed radiologically by MRI as well as arthroscopically. In addition to patient-specific data such as age, BMI and trauma history, the leg axis was determined and accompanying injuries (ligamentous and chondrogenic) were documented.The mean age of the MMRT group was 57.2 (± 11.2) years, and that of the LMRT group 33.9 (± 11.4) years. The BMI was significantly higher in the MMRT group compared to the LMRT (30.5 vs. 25.1). 82.4% of patients in the LMRT group demonstrated an accompanying anterior cruciate ligament (ACL) rupture, whereas only 5.7% of the MMRT were associated with an ACL injury. A trauma was described in only 13.2% of patients of the MMRT group in contrast to 88.2% of the LMRT group. An extrusion 3 mm of the MM in the coronal plane of MRI images could be detected in 86.8% of patients, whereas in the LMRT group, it was 15.7%. The mechanical varus angle was 5.6° in the MMRT group and 2.4° in the LMRT group. The rate and degree of concomitant cartilage damage in the affected compartment was significantly higher in the group with medial root injuries than in the group with lateral root tears.The root injuries of the MM and LM show significant differences in terms of patient age, etiology and accompanying injuries. Root injuries to the medial meniscus are mostly of non-traumatic origin and more likely to occur in the context of medial osteoarthritis and varus deformity of the knee. Lateral root tears tend to be predominantly traumatic and are frequently associated with ACL ruptures. However, in the MMRT group, a small subgroup with a traumatic etiology and in the LMRT group a small subgroup of patients with non-traumatic etiology could be identified.III.
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- 2022
6. Arthroskopisch gestützte Meniskustransplantation ohne Knochenblöcke
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Martin Häner, Katrin Karpinski, Wolf Petersen, and Sebastian Bierke
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Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,Orthopedics and Sports Medicine ,Surgery ,business ,Meniscal repair - Abstract
Ersatz des lateralen oder medialen Meniskus mit einem allogenen Transplantat. Kompletter Verlust des Innen- oder Ausenmeniskus. Dritt- bis viertgradige Knorpelschaden im entsprechenden Kompartiment, unkorrigierte Varus- oder Valgusdeformitaten > 5°, symptomatische Instabilitaten. Kniegelenkarthroskopie uber das hohe anterolaterale Standardportal und Uberprufen der Indikation. Auftauen des allogenen Meniskustransplantates in NaCl bei Raumtemperatur und Inkubation in Vancomycin-Losung. Anfrischung der Kapsel und Resektion von Meniskusresten. Aufsuchen der Insertionszonen am Tibiaplateau, Debridement, Einbringen eines transtibialen Zielgerates und Bohren von Zieldrahten in die Mitte der Insertionszonen. Uberbohren der Zieldrahte mit einem 4,5-mm-Bohrer. Kurze mediale oder laterale Arthrotomie (ca. 2 cm). Armierung von Vorder- und Hinterhorn des Meniskustransplantates mit nichtresorbierbarem Nahtmaterial (z. B. „Fiber wire“ Starke 5). Einbringen von K‑Drahten mit Fadenschlaufe in den tibialen Knochentunnel. Uber die Fadenschlaufen Einzug der Armierungsfaden des Meniskustransplantates in die Knochentunnel sowie Einzug des Meniskustransplantates in das Gelenk. Reposition der Meniskusbasis an die Kapsel und Refixation des Meniskus an der Kapsel mit Inside-out- oder All-inside-Nahten. Sechs Wochen Entlastung, danach schrittweise Belastungssteigerung. Beweglichkeit: 4 Wochen 0‑0-60°, 5. bis 6. Woche 0‑0-90°, danach frei. In der in dieser Arbeit beschriebenen Operationstechnik wurden in unserer Klinik 15 Patienten (6-mal medial, 9‑mal lateral) behandelt. Nach einem Mindestzeitraum von 1 Jahr (Mittelwert = 14,2 Monate) lag die Meniskusextrusion – gemessen in der MRT – bei durchschnittlich 2,7 mm. Der Lysholm-Score stieg von durchschnittlich 70,2 (±7,4) auf 90,1 Punkte (±10,6). In einem Fall musste aufgrund einer fruhen Reruptur 10 Tage nach der Operation eine Revision mit erneuter Meniskusrefixation durchgefuhrt werden. In einem weiteren Fall erfolgte 6 Monate nach der Meniskustransplantation aufgrund einer Reruptur eine Meniskusresektion. Thrombosen, Infektionen oder Arthrofibrosen traten nicht auf.
- Published
- 2021
7. Arthroscopic Posterior Capsulolabral Repair With Suture-First Versus Anchor-First Technique in Patients With Posterior Shoulder Instability (Type B2): Clinical Midterm Follow-up
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Katrin Karpinski, Doruk Akgün, Henry Gebauer, Christian Festbaum, Lucca Lacheta, Kathi Thiele, and Philipp Moroder
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Orthopedics and Sports Medicine - Abstract
Background: Isolated soft tissue injuries of the posterior capsulolabral complex can be addressed arthroscopically, with various anchor systems available for repair. Purpose: To evaluate clinical and patient-reported outcomes after arthroscopic capsulolabral repair in patients with posterior shoulder instability (PSI) and to compare differences in outcomes between patients treated with a suture-first technique (PushLock anchor) and an anchor-first technique (FiberTak all-suture anchor). Study Design: Cohort study; Level of evidence, 3. Methods: Included were 32 patients with dynamic structural PSI (type B2 according to the ABC classification) treated with an arthroscopic posterior capsulolabral repair. After a mean follow-up time of 4.8 ± 3.4 years (range, 2-11) patients were evaluated clinically, and standardized outcome scores were obtained for the Subjective Shoulder Value (SSV), the Western Ontario Shoulder Instability Index (WOSI), Rowe, Kerlan-Jobe Orthopaedic Clinic (KJOC), patient satisfaction (0-5 [best]), and pain on a visual analog scale (VAS; 0-10 [worst]). Results: The overall satisfaction level with the outcome of the surgery was 4.6 ± 0.5 (range, 4-5). No patient suffered from instability events. The mean VAS level for pain was 0.4 ± 0.9 (range, 0-4) at rest and 1.9 ± 2.0 (range, 0-6) during motion. The mean SSV was 80 ± 17 (range, 30-100), the mean postoperative WOSI score 75% ± 19% (range, 18-98), the mean Rowe score 78 ± 20 (range, 10-100), and the mean KJOC score was 81 ± 18 (range, 40-100) for the entire cohort. There was no significant difference between the techniques with regard to range of motion, strength, or clinical outcome scores. Conclusion: Arthroscopic posterior capsulolabral repair was a satisfactory method to treat structural PSI type B2 with regard to stability, pain relief, and functional restoration. The majority of patients had good outcomes. No differences in outcomes were observed between the anchor-first and suture-first techniques.
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- 2023
8. Soaking ACL grafts in vancomycin solution (1 mg/ml) reduces the infection rate without increasing the risk for re-rupture and arthrofibrosis
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Yassen Abdelatif, Wolf Petersen, Katrin Karpinski, Hi Un Park, Tilman Hees, Sebastian Bierke, and Martin Häner
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medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Postoperative Complications ,Vancomycin ,medicine ,Humans ,Orthopedics and Sports Medicine ,Antibiotic prophylaxis ,Arthrofibrosis ,Fixation (histology) ,Arthritis, Infectious ,Anterior Cruciate Ligament Reconstruction ,business.industry ,Anterior Cruciate Ligament Injuries ,General Medicine ,medicine.disease ,Infection rate ,Anti-Bacterial Agents ,Surgery ,surgical procedures, operative ,Orthopedic surgery ,Septic arthritis ,Joint Diseases ,business ,medicine.drug - Abstract
The aim of the present study was to evaluate if the vancomycin (1 mg/ml) is effective for the prevention of septic arthritis after ACL reconstruction. The hypothesis was that local antibiotic prophylaxis by soaking ACL grafts in vancomycin results in significantly less infections than ACL reconstruction without local antibiosis. In group 1, 636 patients who were operated between 1.9.2014 and 31.8.2016 received no local antibiotic treatment with vancomycin. In group 2, 536 patients who were operated between 1.9.2016 and 31.8.2018 received local antibiotic treatment with vancomycin (1 mg/ml). In this group the graft was soaked in the vancomycin solution for 10 min prior to graft passage and fixation. In group 1 (ACL reconstruction without vancomycin application), a postoperative infection was detected in ten patients (infection rate: 1.6%). In group 2 (ACL reconstruction with 1 mg/ml vancomycin), no postoperative infection was detected (infection rate: 0%). The statistical analysis showed a clear significant difference between the two groups (p = 0.002). The re-rupture rate and the rate of arthrofibrosis differed not significantly between the two treatment groups (p = 0.526). The results of the present study show that graft soaking in vancomycin (1 mg/ml) is effective for the prevention of septic arthritis after ACL reconstruction. III.
- Published
- 2021
9. A systematic review about long-term results after meniscus repair
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Katrin Karpinski, Ralf Müller Rath, Sebastian Bierke, Wolf Petersen, and Martin Häner
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Adult ,medicine.medical_specialty ,Adolescent ,Anterior cruciate ligament ,Osteoarthritis ,Meniscus (anatomy) ,Menisci, Tibial ,Arthroscopy ,medicine ,Humans ,Meniscus ,Orthopedics and Sports Medicine ,Child ,Meniscus repair ,Retrospective Studies ,business.industry ,Anterior Cruciate Ligament Injuries ,General Medicine ,Long term results ,medicine.disease ,Tibial Meniscus Injuries ,Surgery ,medicine.anatomical_structure ,Radiological weapon ,Refixation ,Orthopedic surgery ,business - Abstract
Purpose Aim of this systematic review was to analyze long-term results after meniscus refixation. Methods A systematic literature search was carried out in various databases on studies on long-term results after meniscus refixation with a minimum follow-up of 7 years. Primary outcome criterion was the failure rate. Secondary outcome criteria were radiological signs of osteoarthritis (OA) and clinical scores. Results A total of 12 retrospective case series (level 4 evidence) were identified that reported about failure rates of more than 7 years follow-up. There was no statistical difference in the failure rates between open repair, arthroscopic inside-out with posterior incisions and arthroscopic all-inside repair with flexible non-resorbable implants. In long-term studies that examined meniscal repair in children and adolescents, failure rates were significantly higher than in studies that examined adults. Six studies have shown minor radiological degenerative changes that differ little from the opposite side. The reported clinical scores at follow-up were good to very good. Conclusion This systematic review demonstrates that good long-term outcomes can be obtained in patients after isolated meniscal repair and in combination with ACL reconstruction. With regard to the chondroprotective effect of meniscus repair, the long-term failure rate is acceptable. Level of evidence IV.
- Published
- 2021
10. Matrix-induced chondrogenesis is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee: a systematic review
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Sebastian Bierke, Wolf Petersen, Katrin Karpinski, and Martin Häner
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Cartilage, Articular ,medicine.medical_specialty ,Knee Joint ,Transplantation, Autologous ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Defect filling ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Cartilage repair ,Autologous chondrocyte implantation ,030222 orthopedics ,business.industry ,Cartilage ,Treatment options ,030229 sport sciences ,Chondrogenesis ,Surgery ,medicine.anatomical_structure ,Orthopedic surgery ,business ,Cartilage Diseases - Abstract
The purpose of this study was to perform a systematic review of randomized controlled trials comparing the results of matrix-induced chondrogenesis with other therapies for local chondral lesions of the knee. A systematic search for randomized controlled trials (RCT) about matrix-induced chondrogenesis for focal chondral lesions in the knee was performed according to the PRISMA guidelines. Data source was PubMed central, EMBASE and Google scholar. Five articles could be included, whereas two originated from the same study group. Three studies compared matrix-induced chondrogenesis to microfracture (MFx) only. One trial compared AMIC® to collagen-covered autologous chondrocyte implantation (ACI-C). One study assessed the improvements given by the combination of AMIC® with bone marrow aspirate concentrate (BMAC). In three studies, clinical improvements compared to baseline were seen at 2-year postoperation, irrespective of the technique used. After 5 years, one trial showed better results for the AMIC® group compared to MFx, including MRI defect filling. One study showed also good results after AMIC® with faster recovery for patients with AMIC® + BMAC 12 months postoperatively. Results of RCTs comparing matrix-induced chondrogenesis with other treatment options showed that matrix-induced chondrogenesis is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee. This one-stage surgical technique presents a good alternative for patients. I.
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- 2021
11. Meniskusläsionen bei Kindern und Jugendlichen
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Wolf Petersen, Katrin Karpinski, Martin Häner, and Sebastian Bierke
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Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,business - Abstract
Meniskuslasionen sind zwar bei Kindern und Jugendlichen im Vergleich zum Erwachsenen selten, aufgrund der Bedeutung des Hochleistungssports und einer fruhen Sportspezialisierung werden sie aber immer haufiger beobachtet. Meist treten sie im Rahmen eines Knietraumas auf und sind mit einer begleitenden Ruptur des vorderen Kreuzbandes (VKB) assoziiert. Im Rahmen einer VKB-Lasion auftretende Meniskuslasionen betreffen meist die Hinterhorner. Sie konnen sich aber bis zum Korbhenkelriss ausdehnen. Auch die selten – auch isoliert – vorkommende radiare Rissbildung im Bereich der Pars intermedia des Ausenmeniskus ist meist traumatisch bedingt. Die MRT gilt auch beim Kind in der Meniskusdiagnostik als die Methode der Wahl und sollte daher zur Anwendung kommen, wenn der klinische Verdacht auf eine Meniskuslasion vorliegt. Da die Heilungseigenschaften bei kindlichem und jugendlichem Meniskusgewebe besser sein sollen als beim Erwachsenen und zusatzlich ein hohes Arthroserisiko im Langzeitverlauf bei einem Meniskusverlust in jungen Jahren vorliegt, wird die Indikation zur Meniskusrefixation bei Kindern und Jugendlichen sehr groszugig gesehen. Bei Kombinationsverletzungen von VKB und Meniskus wird eine Meniskusnaht in Kombination mit einer VKB-Plastik angestrebt. Bei Radiarlasionen des Ausenmeniskus wird eine partielle Meniskektomie im inneren Drittel mit Horizontalnahten der peripheren zwei Drittel kombiniert. Bei diskoiden Menisken richtet sich die Therapie nach der Risslokalisation. Bei zentralen Lasionen erfolgt meist eine Teilresektion mit Verkleinerung des diskoiden Meniskus, periphere Meniskuslasionen werden refixiert. Beim symptomatischen hypermobilen Meniskus erfolgt eine Augmentation der meniskopoplitealen Bander durch Meniskusnahte.
- Published
- 2020
12. Coronavirus-Pandemie und ihre Auswirkungen auf Orthopädie und Unfallchirurgie: Operationen, Risiken und Prävention?
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Katrin Karpinski, Martin Häner, Wolf Petersen, and Sebastian Bierke
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Gynecology ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Medicine ,Electrical and Electronic Engineering ,business ,Atomic and Molecular Physics, and Optics - Abstract
Um die Auswirkungen von COVID-19 zu beurteilen, mussen allen Mitarbeitern im Gesundheitssystem die Symptome und Verlaufe der Erkrankung bekannt sein. Erfahrungen und Studien aus den initial am starksten betroffenen Regionen China und Italien geben erste Ruckschlusse auf Fragen wie Verlauf der Infektion und Risiko fur das Krankenhauspersonal. Hier deutet sich an, dass operativ versorgte COVID-19-Patienten ein hoheres Risiko im Vergleich zu Nichtinfizierten haben. Weiterhin scheint das OP-Personal einem Infektionsrisiko ausgesetzt zu sein. Um das Gesundheitssystem vor einem Kollaps zu bewahren, mussen Ressourcen an anderer Stelle eingespart werden. Dazu mussen elektive Operationen reduziert werden. Um Kriterien zu entwickeln, wann welche Operationen durchgefuhrt werden konnen, wird die Pandemie in verschiedene Phasen eingeteilt. Diese orientieren sich an der Entwicklung der Pandemiekurve. Dabei sollten bei der Entscheidung, ob eine Operation durchfuhrbar ist, verschiedene Aspekte berucksichtigt werden (Stadium der Pandemie, Funktionsstorung bei Unterlassung, Konflikt mit Ressourcen zur COVID-19-Behandlung, Alternative: ambulante Operation). Die Empfehlungen zur Durchfuhrung von Operationen sollten immer an die aktuelle, regionale und epidemiologische Situation des Hauses und des jeweiligen Einzugsgebietes angepasst werden. Zu diesem Zwecke ist es sinnvoll, ein lokales Komitee im Krankenhaus zu bilden, das diese Lagebeurteilung taglich vornimmt. Generelle Operationsverbote erscheinen medizinisch nicht sinnvoll.
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- 2020
13. Technique of ACL Reconstruction With Autologous Quadriceps Tendon Bone Graft and Femoral Press Fit Fixation
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Wolf Petersen, Julia Ohde, Katrin Karpinski, Sebastian Bierke, and Martin Häner
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
Background: Recently, there has been an increase in interest in the quadriceps tendon (QT) as an alternative autologous graft option for primary anterior cruciate ligament (ACL) reconstruction. Indication: Anterior cruciate ligament reconstruction in skeletally mature patients (high-risk patients for re-rupture and patients with medial instability). Technique Description: The QT graft is harvested with a 4-cm skin incision over the superior pole of the patella. A double knife and an oscillating saw are used to obtain the QT graft with a bone block from the patella (65 mm x 10 mm graft and 15 mm bone block). Then an arthroscopy is carried out with assessment of the ACL tear and treatment of further intraarticular injuries. ACL reconstruction begins with debridement of the femoral insertion to expose the land marks. The medial portal is used for femoral tunnel drilling with the knee in more than 110° of flexion. A special portal aiming device is introduced via the anteromedial portal and a guide wire is placed in the area of the femoral anteromedial insertion. This guide wire is gradually overdrilled with various drills and dilators of increasing size. The final diameter should be 0.5 mm smaller than the diameter of the bone block of the graft to allow for press-fit fixation. Then, the tibial tunnel is drilled using a tibial drill guide leaving the tibial stump of the original ACL intact. The graft is pulled into the joint through the tibial tunnel until the bone block stops at the femoral tunnel entrance. The bone block is then pushed through the medial portal into the femoral tunnel (press-fit fixation). The tibial fixation is performed with an interference screw and optionally with an extracortical button. Results: Prior studies with 2 years follow-up have shown that the clinical outcomes in primary and revision ACL reconstruction were not significantly different between the use of QT grafts with femoral press-fit fixation and the use of hamstring grafts with femoral suspension fixation. Discussion/Conclusion: Quadriceps tendon bone autograft and femoral press-fit fixation provides an excellent alternative as a graft choice in ACL reconstruction. The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
- Published
- 2022
14. Arthroscopic Bone Block Cerclage Technique Using a Tricortical Scapular Spine Autograft for Glenoid Reconstruction in Patients With Anterior Shoulder Instability
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Philipp Moroder, Thiele Kathi, Lucca Lacheta, Katrin Karpinski, Alp Paksoy, and Doruk Akgün
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Orthopedics and Sports Medicine - Abstract
In the treatment of anterior shoulder instability with glenoid bone loss, free bone graft transfers have proven to be a viable anatomic alternative to the commonly performed, nonanatomic Latarjet procedure. Implant-free fixation of the free bone grafts, in particular, has rendered excellent short- and long-term results. However, a drawback remains the source of the graft. We describe an arthroscopic bone block cerclage technique using a tricortical scapular spine autograft, which provides an anatomic arthroscopic glenoid reconstruction with the combined benefit of sparing the subscapularis, metal-free fixation, and intraregional donor site for autograft harvesting.
- Published
- 2021
15. No increased rate of cyclops lesions and extension deficits after remnant-preserving ACL reconstruction using the sparing technique
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Sebastian Bierke, Martin Häner, Katrin Karpinski, Tilman Hees, and Wolf Petersen
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Treatment Outcome ,Humans ,Pain ,Orthopedics and Sports Medicine ,Surgery ,Minocycline ,Prospective Studies ,Anterior Cruciate Ligament - Abstract
Background Remnant-preserving anterior cruciate ligament reconstruction (ACLR) should have advantages for postoperative remodeling and proprioception. However, it has been suggested that the larger diameter of the graft tends to lead to impingement phenomena with a higher rate of cyclops lesions. The aim of this work was to find out whether the remnant-preserving ACLR actually leads to an increased rate of range of motion restraints compared to the remnant-sacrificing technique. Methods Patients, who fulfilled the inclusion criteria, were followed up for one year after surgery. The primary endpoint was arthrolysis due to extension deficit or cyclops syndrome. Secondary outcome measures were pain (NRS), knee function (KOOS), patient satisfaction and return to sports rate. Results One hundred and sixty-four patients were included in the study, 60 of whom received the “remnant augmentation” procedure (group 1). In the remnant augmentation group, one cyclops resection was performed, whereas in the non-remnant augmentation group three cyclops lesion resections had to be performed (odds ratio 0.6). There was no difference between the groups in pain (NRS) and knee function (KOOS) and patient satisfaction. The return to sports rate after one year was higher in the remnant augmentation group. Conclusions Patients who have undergone the sparing “remnant augmentation” ACLR have no increased risk of cyclops lesion formation or extension deficit in the first year after surgery. An improvement of the proprioceptive abilities by remnant augmentation ACLR should be investigated in further studies. Level of evidence III (prospective cohort study).
- Published
- 2021
16. 'Fast-Track-Konzepte' in der Knieendoprothetik: Einsatz von Tranexamsäure und Technik der lokalen intraartikulären Anästhesie
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Katrin Karpinski, Wolf Petersen, Sebastian Bierke, Martin Häner, and Tillmann Hees
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Gynecology ,030222 orthopedics ,medicine.medical_specialty ,business.industry ,Total knee arthroplasty ,03 medical and health sciences ,0302 clinical medicine ,Intra articular ,medicine ,Orthopedics and Sports Medicine ,Surgery ,030212 general & internal medicine ,business ,Tranexamic acid ,medicine.drug - Abstract
„Fast-Track-Konzepte“ dienen der Verminderung des Risikos fur peri- und postoperative Komplikationen nach Implantation einer Knievollprothese. Die beschriebenen Konzepte werden eingesetzt bei Patienten mit der Indikation zur Implantation einer Knievollprothese. Kontraindikationen fur „Fast-Track-Konzepte“ sind: hochbetagte Patienten, Demenz, ASA-Klasse IV (gemas American Society of Anesthesiologists), Implantation groser Revisions- oder Tumorprothesen. Kontraindikationen fur Tranexamsaure sind: Blutungen im Harntrakt, Vorsicht bei bekannter Epilepsie, individuelle Risikoabwagung bei bestehenden Thrombosen bzw. erhohtem Thromboserisiko, frischer Herzinfarkt, Z. n. frischer Lungenembolie, Z. n. perkutaner transluminaler Koronarangioplastie (PTCA) oder Z. n. Stentimplantation. Kontraindikationen fur Ropivacain sind: Uberempfindlichkeit (Allergie) gegen Ropivacain und andere Lokalanasthetika vom Amidtyp, Hypovolamie. Praoperativ wird die Gabe von 1 g Tranexamsaure und intraoperativ eine lokale Infiltrationsanasthesie durchgefuhrt. Dazu erfolgt nach der femoralen und tibialen Knochenresektion, vor der Zementierung der femoralen und tibialen Komponenten, die Injektion von etwa 40 ml Ropivacain (2 %) in die posteriore Kapsel. Weiter erfolgt die Injektion von jeweils etwa 20 ml Lokalanasthetikum in die medialen und lateralen Seitenbander und die Infiltration des Hoffa-Fettkorpers sowie des Streckapparats mit ebenfalls etwa 20 ml Lokalanasthetikum. Nach der Zementierung wird das Subkutangewebe mit etwa 50 ml Ropivacainlosung infiltriert. Noch am Operationstag wird der Patient unter krankengymnastischer Anleitung mobilisiert. Dabei soll der Patient, wenn moglich, bereits einige Schritte an 2 Unterarmgehstutzen gehen. Die systemische analgetische Therapie erfolgt nach WHO-Stufenschema II mit einem schwach wirksamen Opioid und Nichtopioidanalgetika der ersten Stufe (nichtsteroidale Antirheumatika, NSAR, und/oder Metamizol). Als adjuvante Komedikation kann Gabapentin eingesetzt werden. Die medikamentose Thromboseprophylaxe erfolgt fur 2 Wochen postoperativ mit einem niedermolekularen Heparin. Bei 100 Patienten, die praoperativ 1 g Tranexamsaure sowie eine intraartikulare Infiltrationsanasthesie erhalten hatten, lag der Schmerz am Abend des Op.-Tags auf der numerischen Ratingskala (NRS) durchschnittlich bei 2,1 (±1,8). Bei einem Patienten bestand ein sensibles Defizit am Unterschenkel und Fus. Ein motorischer Ausfall wurde nicht beobachtet. Es konnten 90 Patienten das gestreckte Bein anheben. Am Op.-Tag konnten 68 Patienten mehr als 10 Schritte gehen, 22 Patienten konnten in den Stand mobilisiert werden. Die mittlere stationare Verweildauer lag bei 6,6 Tagen (5–11 Tage). Infektionen, Thrombosen und Lungenembolien traten nicht auf.
- Published
- 2019
17. Die primäre Revision mit Replastik des vorderen Kreuzbandes
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Martin Häner, Sebastian Bierke, Tillmann Hees, Wolf Petersen, and Katrin Karpinski
- Subjects
Gynecology ,030222 orthopedics ,medicine.medical_specialty ,business.industry ,Anterior cruciate ligament ,Treatment outcome ,Joint instability ,Hand surgery ,030229 sport sciences ,Knee Joint ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Orthopedics and Sports Medicine ,Surgery ,Anterior Cruciate Ligament Injuries ,business ,Knee injuries - Abstract
Wiederherstellung der Kniestabilitat nach Reruptur einer vorderen Kreuzband-(VKB-)Plastik. Akute und chronische funktionelle Instabilitat mit Reruptur eines VKB-Transplantats bei anatomischen oder nichtanatomischen Knochentunneln ohne Tunnelweitung. Partiell anatomische Knochentunnel der vorherigen Operation, signifikante Tunnelweitung anatomischer Knochentunnel, lokale Infektion im Bereich des Kniegelenks, lokale Weichteilschadigung. Geeignete Revisionstransplantate sind die autologen Beugesehnen (M. semitendinosus, M. gracilis), die Quadrizepssehne, die Patellarsehne sowie ein Peroneussehnen-Split-Graft. Bei anatomischen Tunneln sorgfaltiges Debridement bis auf die Tunnelwand; bei nichtanatomischen Tunneln der Voroperation Bohren des femoralen Kanals uber ein tiefes anteromediales Portal bei mehr als 110° gebeugtem Knie im VKB-Insertionsgebiet. Eine schonende Tunnelpraparation gelingt mit Dilatatoren. An der Tibia dient das Ausenmeniskusvorderhorn bei fehlendem VKB-Stumpf als Landmarke. Sondieren der gelenkfernen Tunneloffnung mit einem Zieldraht und schrittweises Aufbohren der Tunnel bis zum Erreichen der Tunnelwand, die mit einem Loffel oder Synovialresektor debridiert wird. Dabei Entfernen von Transplantatresten und Implantaten aus dem Tunnel. Die femorale Fixation erfolgt mit einem Kippanker, einer Interferenzschraube oder bei einem Knochenblocktransplantat auch implantatfrei. Transplantatfixierung tibial mit resorbierbarer Interferenzschraube und Fixationsknopf. Nachbehandlungsschema besteht aus 4–5 Phasen. Entzundungsphase I (1.–2. Woche): Schmerz- und Ergussprophylaxe (Kuhlung, isometrische Anspannungsubungen, 20-kg-Teilbelastung). Phase II (2.–6. Woche): Langsame Steigerung von Belastung und Beweglichkeit mit Ubungen in geschlossener Kette (Ziel: Extension/Flexion 0–0–120°). Phase III (ab der 6. Woche): Kraftaufbau und Koordinationsubungen. Phase IV: Balance, Kraft und Sprungubungen. Wiederkehr zum Wettkampfsport nicht vor dem 6.–10. postoperativen Monat. Nachuntersucht wurden 51 Patienten mit Rezidivinstabilitat nach VKB-Plastik, bei denen ein primarer Reersatz des VKB mit ipsilateralem Knochen-Quadrizepssehnen-Transplantat oder kontralateralem Semitendinosus-Gracilis-Transplantat durchgefuhrt wurde. Alle Patienten hatten anatomische oder nichtanatomische Bohrkanalpositionen ohne signifikante Bohrkanalweitung (>11 mm). Nach 2 Jahren betrug der Seit-zu-Seit-Unterschied fur die anteriore Translation gemessen mit dem KT-1000-Arthrometer 2,0 ± 1,2 mm fur die Quadrizeps-Gruppe und 3,0 ± 2,9 mm fur die Semitendinosus-Gracilis-Gruppe (P = 0,461). Kein Unterschied in der Rate positiver Pivot-Shift-Tests (P = 0,661), kein signifikanter Unterschied in den einzelnen Subscores des KOOS (Knee Injury and Osteoarthritis Outcome Score) sowie beim vorderen Knieschmerz.
- Published
- 2019
18. No dynamic extrusion of the medial meniscus in ultrasound examination in patients with confirmed root tear lesion
- Author
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Andreas B. Imhoff, Katrin Karpinski, Lukas Willinger, Andrea Achtnich, Wolf Petersen, and Theresa Diermeier
- Subjects
Male ,medicine.medical_specialty ,Supine position ,Meniscus (anatomy) ,Menisci, Tibial ,Weight-Bearing ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Supine Position ,medicine ,Humans ,Orthopedics and Sports Medicine ,Aged ,Ultrasonography ,Rupture ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Magnetic resonance imaging ,030229 sport sciences ,Middle Aged ,musculoskeletal system ,Magnetic Resonance Imaging ,Tibial Meniscus Injuries ,medicine.anatomical_structure ,Case-Control Studies ,Orthopedic surgery ,Tears ,Female ,Surgery ,medicine.symptom ,Radiology ,business ,Nuclear medicine ,Medial meniscus - Abstract
Extrusion of the medial meniscus evaluated on magnetic resonance imaging (MRI) has been described as indirect radiological sign for meniscus root tears. However, ultrasound detectable dynamic extrusion is observed in normal physiological settings. The aim of the present study was to analyze the dynamic meniscal extrusion using ultrasound (US) examination in patients with MRI-confirmed meniscal root tears. The hypothesis was that dynamic meniscus extrusion is reduced in patients with medial root tear but not in the healthy meniscus. Twenty-five patients with a medial root lesion of the meniscus (group I) and 25 healthy controls (group II) were enrolled in this study. The medial meniscus extrusion (MME) of the index knee was determined using ultrasound (US) in supine position and under full weight bearing. Standard knee MRI was used for determining whether the patients were eligible for this study according to the inclusion and exclusion criteria, respectively. In group I, the mean MME was 3.6 mm (± 1.0 mm) in supine position and 3.7 mm (± 0.9 mm) under full weight bearing according to US measurements. The mean Δ-extrusion was 0.1 mm (± 0.2 mm) and the ratio was 1.0 (± 0.1). Mean medial meniscus extrusion on MRI was 3.9 mm (± 0.9 mm). In group II, mean MME was 1.3 mm (± 0.3 mm) in supine position (US) and 2.3 mm (± 0.4 mm) under full weight bearing (US). The mean Δ-extrusion was 1.0 mm (± 0.4 mm) and the extrusion ratio was 1.8 (± 0.4). In this group, mean extrusion in MRI was 1.4 mm (± 0.7 mm). The difference in mean ultrasound Δ-extrusion, ratio, and MRI extrusion between both groups was statistically significant (p
- Published
- 2019
19. A systematic review about telemedicine in orthopedics
- Author
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Katrin Karpinski, Martin Häner, Wolf Petersen, Luisa Backhaus, and Sebastian Bierke
- Subjects
Telemedicine ,medicine.medical_specialty ,Cost effectiveness ,medicine.medical_treatment ,Video consultation ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Telerehabilitation ,Health care ,medicine ,Humans ,Orthopedics and Sports Medicine ,Orthopedic Procedures ,Diagnostics ,Orthopedic surgery ,030222 orthopedics ,Pandemic ,business.industry ,SARS-CoV-2 ,COVID-19 ,Workload ,030229 sport sciences ,General Medicine ,Arthroplasty ,Knee arthroplasty ,Orthopedics ,Arthroscopy and Sports Medicine ,Physical therapy ,Surgery ,business - Abstract
Purpose Until now, the use of telemedical applications in orthopedics was limited to sparsely populated countries. However, due to the SARS-CoV-2 pandemic, interest in orthopedics in these procedures has increased significantly. The aim of this systematic review was to find out to what extent there is scientific evidence for the use of telemedicine in the orthopedic field. Methods A systematic literature search was carried out in various databases on randomized controlled trials (RCTs) on telemedical applications in orthopedics. Results Altogether, 14 articles were identified that reported about a total of eight RCTs of telemedical applications in orthopedics. Two RCTs were about a patient-to-doctor video consultation and six RCTs were about telerehabilitation after knee and hip arthroplasty (4 × knee arthroplasty, one hip and knee arthroplasty, one hip arthroplasty). For the majority of outcome parameters evaluated, there were no significant differences between the study groups. The cost effectiveness of videoconsultations depended on the workload (number of patient consultations) as well as the effectiveness of telerehabilitation on the distance of the patient's home to the health care center (30 km round-trip). Conclusion There is sufficient evidence to recommend the use of telemedical methods in orthopedics. However, more research is necessary to further expand the possibilities of telemedical methods with regard to physical examination.
- Published
- 2020
20. Einzeitige Revision nach vorderer Kreuzbandplastik mit autologer Quadrizepssehne
- Author
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Katrin Karpinski, M. Häner, and Wolf Petersen
- Subjects
Gynecology ,030222 orthopedics ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,media_common.quotation_subject ,medicine ,Orthopedics and Sports Medicine ,030229 sport sciences ,Art ,media_common - Abstract
Ziel der Revisionsoperation nach Versagen einer vorderen Kreuzbandplastik ist es, das Kniegelenk erneut mit einem autologen Sehnentransplantat zu stabilisieren. Eine einzeitige Revision ist nur moglich bei korrekter anatomischer oder nichtanatomischer Tunnellage ohne signifikante Tunnelweitung. Die autologe Quadrizepssehne ist hier ein ideales Transplantat fur die Revisionschirurgie. Nach praoperativer klinischer und radiologischer Diagnostik werden zunachst die Tunnelpositionen arthroskopisch begutachtet. Dann erfolgen bei anatomischer Tunnellage das Debridement sowie die Grosenbestimmung des femoralen Tunnels. Bei extraanatomischem femoralem Tunnel wird dieser uber das mediale Portal mit Hilfe eines speziellen Portalzielgerats bei mehr als 110° gebeugtem Knie neu angelegt. Als Landmarken dienen die Linea intercondylaris und die Knorpel-Knochen-Grenze am lateralen Femurkondylus. Die Position des Zieldrahts wird kontrolliert, indem das Arthroskop in das mediale Portal eingefuhrt wird. Die Entnahme der autologen Quadrizepssehne erfolgt mit speziellem Instrumentarium. Das Transplantat wird mit einem Knochenblock entnommen. An der Tibia wird die ehemalige Hautinzision am Tibiakopf eroffnet und der Tunneleingang aufgesucht. Dann wird in den ehemaligen Tunnel ein Fuhrungsdraht eingefuhrt und dieser soweit uberbohrt, bis samtliche Transplantatreste entfernt und die Sklerose der Tunnelwand eroffnet ist. Das Transplantat wird in das Gelenk gezogen und am Femur mit dem Knochenblock in Press-fit-Technik fixiert. An der Tibia wird eine Hybridfixation mit resorbierbarer Interferenzschraube sowie Fixationsbutton durchgefuhrt. Die autologe Quadrizepssehne ist eine wichtige Transplantatalternative in der Revisionschirurgie des vorderen Kreuzbands (VKB).
- Published
- 2018
21. Erfolgreiche kniegelenknahe Osteotomie bei viertgradiger bikompartimenteller Gonarthrose und erheblicher Varusdeformität
- Author
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Katrin Karpinski, Tillmann Hees, Wolf Petersen, and Sebastian Bierke
- Subjects
business.industry ,Medicine ,Orthopedics and Sports Medicine ,business - Published
- 2018
22. Differences in Patients’ and Surgeons’ Expectations before Shoulder Stabilization Surgery
- Author
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Fabian Plachel, Alexander Auffarth, Mark Tauber, Christian Gerhardt, Katrin Karpinski, Doruk Akgün, Tim Saier, and Philipp Moroder
- Subjects
surgeons’ expectations ,medicine.medical_specialty ,business.industry ,shoulder instability ,Significant difference ,General Medicine ,Article ,Surgery ,patients’ expectations ,medicine ,Shoulder instability ,Medicine ,Anxiety ,In patient ,shoulder stabilization ,medicine.symptom ,Range of motion ,business ,Surgical treatment - Abstract
Purpose: The primary goal of shoulder stabilization procedures is to re-establish stability and many surgeons measure the success after shoulder stabilization surgery only by the absence of re-dislocation. However, patients might also suffer from pain, loss of range of motion and strength as well as anxiety and stigmatization and therefore have other expectations from a stabilization surgery than just a stable shoulder. Purpose of this study was to analyze if surgeons know what their patients typically expect from a shoulder stabilization surgery. Furthermore, the aim was to analyze the influence of various factors on patients’ expectations. Materials and Methods: 204 patients with a diagnosis of shoulder instability scheduled for surgical treatment were included in this prospective multicentric study. Preoperatively, objective and subjective scores were obtained and patients were asked about their postoperative expectations. Additionally, 25 surgeons were interviewed with regard to what they think their patients expect from the surgery using standardized questions. Results: With regard to postoperative expectations surveyed by the Hospital for Special Surgery questionnaire (HSS), the most important goal to achieve for the patients was ‘stopping the shoulder from dislocation’, followed by ‘to improve the ability to exercise or participate in sports’ and ‘being the shoulder to be back the way it was before the issue started’. The ranking of factors for patients was ‘stability’ as the most important to achieve, followed by ‘movement’, ‘strength’, ‘pain’ and ‘cosmetics’. For surgeons, the order was ‘stability’ (p = 0.004 **), ‘movement’ (p = 0.225), ‘pain’ (p = 0.509), ‘strength’ (p = 0.007 **) and ‘cosmetics’ (p = 0.181). There was a significant difference between patients and surgeons with regard to gaining stability at the cost of movement (p = 0.001 **). Conclusion: Patients and surgeons expectations regarding outcome after surgical shoulder stabilization procedures are quite similar with limited topics of disagreement. Generally, surgeons tend to overrate the importance of stability at the costs of other factors.
- Published
- 2021
23. Comparing Knee Laxity After Anatomic Anterior Cruciate Ligament Reconstruction Using Quadriceps Tendon Versus Semitendinosus Tendon Graft
- Author
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Martin Häner, Theresa Diermeier, Katrin Karpinski, Wolf Petersen, and Sebastian Bierke
- Subjects
Orthodontics ,hamstrings ,030222 orthopedics ,Anterior cruciate ligament reconstruction ,business.industry ,Anterior cruciate ligament ,medicine.medical_treatment ,030229 sport sciences ,musculoskeletal system ,Article ,ACL reconstruction ,03 medical and health sciences ,surgical procedures, operative ,0302 clinical medicine ,medicine.anatomical_structure ,Knee laxity ,quadriceps tendon ,Medicine ,Orthopedics and Sports Medicine ,Semitendinosus tendon ,Quadriceps tendon ,business ,press-fit technique - Abstract
Background: The choice of graft in anterior cruciate ligament (ACL) reconstruction is still under discussion. The hamstrings are currently the most used grafts for primary ACL reconstruction in Europe. However, increased interest has arisen in the quadriceps tendon (QT) as an alternative autologous graft option for primary ACL reconstruction. Purpose: To evaluate knee stability and the subjective outcome after ACL reconstruction using either autologous QT graft in implant-free femoral press-fit fixation technique or semitendinosus tendon (ST) graft. Study Design: Cohort study; Level of evidence, 2. Methods: We evaluated 50 patients who underwent ACL reconstruction, including 25 patients who received autologous ipsilateral QT graft (QT group) and 25 patients who received the ipsilateral ST graft (ST group). The follow-up for this prospective comparative study was at least 2 years after surgery, comprising KT-1000 arthrometer testing, pivot-shift test, Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm score, and rerupture rate. Results: The mean patient age was 31.72 years (9 women, 16 men) in the QT group and 32.08 years (13 women, 12 men) in the ST group. The mean ± standard deviation postoperative side-to-side difference assessed using KT-1000 arthrometer was 1.56 ± 1.56 mm for the QT group and 1.64 ± 1.41 mm for the ST group, with no significant difference. No significant difference was found on any of the KOOS subscale scores ( P = .694) or the Lysholm score ( P = .682). No rerupture or positive pivot-shift test occurred during follow-up. No difference was found in donor-site morbidity between the study groups. Conclusion: Clinical outcomes were not significantly different between QT and ST grafts in the current study. Thus, the QT may serve as a good alternative graft for primary ACL reconstruction.
- Published
- 2021
24. Beidseitiger Horizontalriss des Innen- und Außenmeniskus nach Hyperextensionstrauma
- Author
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Wolf Petersen and Katrin Karpinski
- Subjects
0301 basic medicine ,Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,030104 developmental biology ,0302 clinical medicine ,Philosophy ,medicine ,Orthopedics and Sports Medicine ,030218 nuclear medicine & medical imaging - Abstract
Wir berichten uber einen 19-jahrigen Patienten, der beim Rugby ein Hyperextensionstrauma des rechten Kniegelenks mit traumatischen Horizontallasion des Innen- und Ausenmeniskus erlitten hatte. Diese Art von Meniskusriss tritt normalerweise im Rahmen eines degenerativen Geschehens auf. In unserem vorgestellten Fall sprachen neben einem adaquaten Unfallmechanismus arthroskopisch die im Meniskusriss erkennbaren Koagel fur die traumatische Genese der Horizontallasionen.
- Published
- 2017
25. Vergleich der Quadrizeps- und Semitendinosussehne als Transplantate für die primäre VKB-Rekonstruktion – eine klinische prospektive Studie
- Author
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Martin Häner, Sebastian Bierke, Wolf Petersen, Katrin Karpinski, Hi Un Park, and Tilman Hees
- Subjects
Orthopedics and Sports Medicine ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2020
26. Midterm Effect of Mental Factors on Pain, Function, and Patient Satisfaction 5 Years After Uncomplicated Total Knee Arthroplasty
- Author
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Katrin Karpinski, Tilman Hees, Sebastian Bierke, Wolf Petersen, and Martin Häner
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Knee replacement ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,medicine ,Humans ,Orthopedics and Sports Medicine ,Prospective Studies ,Prospective cohort study ,Arthroplasty, Replacement, Knee ,030222 orthopedics ,Pain, Postoperative ,business.industry ,Catastrophization ,Osteoarthritis, Knee ,medicine.disease ,Patient Health Questionnaire ,Treatment Outcome ,Patient Satisfaction ,Physical therapy ,Anxiety ,Pain catastrophizing ,medicine.symptom ,business ,Somatization ,Psychopathology - Abstract
Background The effects of psychological factors on the short-term outcome after uncomplicated total knee arthroplasty (TKA) have been described in several studies. However, the effects of mental factors on the midterm (5-year) outcome have not been described in the literature. This study was performed to examine the influence of pain catastrophizing, anxiety, depression symptoms, and somatization dysfunction on the outcome of TKA during a 5-year follow-up. Methods One hundred fifty patients were enrolled in this prospective study. The following mental parameters were assessed in all patients: pain catastrophizing (Pain Catastrophizing Scale), anxiety (State-Trait Anxiety Inventory), depressive symptoms and somatization dysfunction (Patient Health Questionnaire). The primary outcome measure was postoperative pain on a numerical rating scale. The secondary outcome measures were the Knee Injury and Osteoarthritis Outcome Score and patient satisfaction. Intergroup differences were tested using an independent t-test. Odds ratios were calculated to determine the probability of an unsatisfactory outcome. Results At the 5-year follow-up, only depressive symptoms and somatization dysfunction had a significant effect on postoperative pain (numerical rating scale score). This significant effect was also observed for the different Knee Injury and Osteoarthritis Outcome Score subscales and patient satisfaction (P = .010-.020). Pain catastrophizing and anxiety had only a small effect on the clinical outcome at 5 years postoperatively. Conclusion The effects of psychopathological factors (depressive symptoms and somatization dysfunction) on the clinical outcome after uncomplicated TKA persist for up to 5 years. Preoperative screening for and subsequent treatment of these psychological disorders may improve patient-reported outcomes after TKA. Level of Evidence Level II, diagnostic study.
- Published
- 2019
27. Arthrofibroserisiko bei anatomischer Rekonstruktion des vorderen Kreuzbandes: die Rolle des Operationszeitpunktes
- Author
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Martin Häner, Wolf Petersen, Sebastian Bierke, Tilman Hees, and Katrin Karpinski
- Subjects
Orthopedics and Sports Medicine ,Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2020
28. Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment
- Author
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Wolf Petersen, Ralf Müller-Rath, Katrin Karpinski, Phillipp Niemeyer, and Peter Angele
- Subjects
medicine.medical_specialty ,Crystal Arthropathies ,Knee Joint ,Osteoarthritis ,law.invention ,03 medical and health sciences ,Arthroscopy ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Orthopedics and Sports Medicine ,Therapeutic Irrigation ,Meniscectomy ,Randomized Controlled Trials as Topic ,Lateral meniscus ,030222 orthopedics ,Intention-to-treat analysis ,medicine.diagnostic_test ,business.industry ,Sham surgery ,030229 sport sciences ,Osteoarthritis, Knee ,medicine.disease ,Surgery ,Tibial Meniscus Injuries ,medicine.anatomical_structure ,Debridement ,Orthopedic surgery ,business ,Medial meniscus - Abstract
The purpose of this study was to perform a systematic review of prospective randomized controlled trials comparing arthroscopic treatment for knee osteoarthritis (OA) with either other therapeutic interventions or sham treatment. A systematic search for randomized controlled trials (RCT) about arthroscopic treatment (AT) for knee OA was performed according to the PRISMA guidelines. Arthroscopic treatment included procedures such as lavage, debridement and partial meniscectomy of the knee. Data source was PubMed central. Fourteen articles could be included. Five studies compared interventive AT with either sham surgery, lavage or diagnostic arthroscopy. Nine trials compared AT with another active intervention (exercise, steroid injection, hyaluronic acid injection). In ten trials, the clinical scores improved after arthroscopic treatment of knee OA in comparison to the baseline. In seven trials, there was a significant difference in the final clinical outcome with higher scores for patients after arthroscopic OA treatment in comparison to a control group. In four trials, the intention to treat analysis revealed no significant difference between arthroscopic OA treatment and the control group. In one of those trials, which compared arthroscopic partial meniscectomy (APM) with exercise, the cross over rate from exercise to AT was 34.9%. The clinical scores of cross-over patients improved after APM. In one study, the subgroup analysis revealed that patients with tears of the anterior two-thirds of the medial meniscus or any lateral meniscus tear had a higher probability of improvement after arthroscopic surgery than did patients with other intraarticular pathology. There was no difference in the side effects between patients with AT and the control group. Despite acceptable scores in the methodological quality assessment, significant flaws could be found in all studies. These flaws include bad description of the exact surgical technique or poor control of postoperative use of non-steroidal anti-inflammatory drugs (NSAID). Results of RCTs comparing AT with other treatment options were heterogeneous. AT in OA patients is not useless because there is evidence that a subgroup of patients with non-traumatic flap tears of the medial meniscus or patients with crystal arthropathy benefit from arthroscopy. This topic has a high relevance because several health insurances do not reimburse arthroscopy for patients with OA anymore. The results of these randomized studies, however, should be interpreted with care because in many studies, the use of other therapeutic variables such as pain killers or NSAIDs was not controlled or reported. I.
- Published
- 2018
29. Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures
- Author
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Martijn van Griensven, Claudine Seeliger, Katrin Karpinski, Helen Vester, Andreas Schmitt, Jan S. Bauer, and Alexander T. Haug
- Subjects
Circulating mirnas ,Oncology ,Pathology ,medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Cancer ,Context (language use) ,Bone healing ,medicine.disease ,Bone tissue ,medicine.anatomical_structure ,Skeletal disorder ,Internal medicine ,microRNA ,Medicine ,Orthopedics and Sports Medicine ,business - Abstract
Osteoporosis as a systemic skeletal disorder is characterized by increased bone fragility and the risk of fractures. According to the World Health Organization, osteoporosis is one of the 10 most common diseases and affects approximately 75 million people in Europe, the United States, and Japan. In this context, the identification of specific microRNA (miRNA) signatures is an important step for new diagnostic and therapeutic approaches. The focus of interest on miRNAs as biomarkers came with new publications identifying free circulating extracellular miRNAs associated with various types of cancer. This study aimed to identify specific miRNAs in patients with osteoporotic fractures compared with nonosteoporotic fractures. For the array analysis, miRNAs were isolated from the serum of 20 patients with hip fractures, transcribed, and the samples were pooled into 10 osteoporotic and 10 nonosteoporotic specimens. With each pool of samples, human serum and plasma miRNA PCR arrays were performed, which are able to identify 83 different miRNAs. Subsequently, a separate validation analysis of each miRNA found to be regulated in the array followed with miRNA samples isolated from the serum of 30 osteoporotic and 30 nonosteoporotic patients and miRNA samples isolated from the bone tissue of 20 osteoporotic and 20 nonosteoporotic patients. With the validation analysis of the regulated miRNAs, we identified 9 miRNAs, namely miR-21, miR-23a, miR-24, miR-93, miR-100, miR-122a, miR-124a, miR-125b, and miR-148a, that were significantly upregulated in the serum of patients with osteoporosis. In the bone tissue of osteoporotic patients, we identified that miR-21, miR-23a, miR-24, miR-25, miR-100, and miR-125b displayed a significantly higher expression. A total of 5 miRNAs display an upregulation both in serum and bone tissue. This study reveals an important role for several miRNAs in osteoporotic patients and suggested that they may be used as biomarkers for diagnostic purposes and may be a target for treating bone loss and optimizing fracture healing in osteoporotic patients.
- Published
- 2014
30. Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures
- Author
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Claudine Seeliger, Katrin Karpinski, Alexander T Haug, Helen Vester, Andreas Schmitt, Jan S Bauer, and Martijn van Griensven
- Subjects
Endocrinology, Diabetes and Metabolism ,Orthopedics and Sports Medicine - Published
- 2014
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