87 results on '"Jin-Ming, Zhang"'
Search Results
2. Functional Cellulose Materials Fabricated by Using Ionic Liquids as the Solvent
- Author
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Yi-Rong Wang, Chun-Chun Yin, Jin-Ming Zhang, Jin Wu, Jian Yu, and Jun Zhang
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Polymers and Plastics ,General Chemical Engineering ,Organic Chemistry - Published
- 2022
3. Hydrogen-Bonding Interactions in Polymer–Organic Solvent Mixtures
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Ming-Xuan Du, Ya-Fei Yuan, Jin-Ming Zhang, and Chen-Yang Liu
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Inorganic Chemistry ,Polymers and Plastics ,Organic Chemistry ,Materials Chemistry - Published
- 2022
4. Characterization and diabetic wound healing benefits of protein-polysaccharide complexes isolated from an animal ethno-medicine Periplaneta americana L
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Qian, Liao, Lan, Pang, Jing-Jing, Li, Chen, Zhang, Jia-Xing, Li, Xing, Zhang, Ting, Mao, Ding-Tao, Wu, Xiu-Ying, Ma, Fu-Neng, Geng, and Jin-Ming, Zhang
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Wound Healing ,Chemical Phenomena ,Macromolecular Substances ,Spectrum Analysis ,Monosaccharides ,Biocompatible Materials ,General Medicine ,Biochemistry ,Cell Line ,Diabetes Mellitus, Experimental ,Mice ,Polysaccharides ,Structural Biology ,Animals ,Humans ,Insect Proteins ,Periplaneta ,Medicine, Traditional ,Amino Acids ,Molecular Biology - Abstract
Periplaneta americana L. (PA), a type of animal medicine, has been widely used for wound healing in clinical settings. In order to further investigate the bioactive wound healing substances in PA, crude PA protein-polysaccharide complexes were further purified by cellulose DE-52 and Sephadex G100 chromatography in succession. Among these isolated fractions, two fractions eluted by 0.3 M and 0.5 M NaCl with the higher yield, respectively named PaPPc2 and PaPPc3 respectively, were chosen for the wound healing experiments. Mediated by HPGPC, amino acid and monosaccharide composition analysis, circular dichroism spectrum, glycosylation type, FT-IR, and
- Published
- 2022
5. Elastodynamic analysis of synergistic oscillation system driven by double servomotors for continuous casting mold
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Chen Lv, Da-wei Liu, Jin-ming Zhang, and Xin Jin
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Materials science ,Mechanics of Materials ,Oscillation ,Materials Chemistry ,Metals and Alloys ,Continuous casting mold ,Composite material ,Servomotor - Published
- 2021
6. Free vibration of functionally graded piezoelectric hexagonal quasicrystal plates
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Yang Li, Jin-ming Zhang, Yang Gao, Yunzhi Huang, Liangliang Zhang, and Han Zhang
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Vibration ,Materials science ,Mechanics of Materials ,Hexagonal crystal system ,Applied Mathematics ,Quasicrystal ,Composite material ,Piezoelectricity - Published
- 2021
7. Static response of functionally graded multilayered two-dimensional quasicrystal plates with mixed boundary conditions
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Liangliang Zhang, Yuxuan Wang, Han Zhang, Xin Feng, Jin-ming Zhang, and Yang Gao
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Partial differential equation ,Materials science ,Field (physics) ,Mechanics of Materials ,Applied Mathematics ,Mechanical Engineering ,Mathematical analysis ,Quasicrystal ,Partial derivative ,Boundary value problem ,Fourier series ,Differential (mathematics) ,Quadrature (mathematics) - Abstract
The unusual properties of quasicrystals (QCs) have attracted tremendous attention from researchers. In this paper, a semi-analytical solution is presented for the static response of a functionally graded (FG) multilayered two-dimensional (2D) decagonal QC rectangular plate with mixed boundary conditions. Based on the elastic theory of FG 2D QCs, the state-space method is used to derive the state equations composed of partial differential along the thickness direction. Besides, the Fourier series expansion and the differential quadrature technique are utilized to simulate the simply supported boundary conditions and the mixed boundary conditions, respectively. Then, the propagator matrix which connects the field variables at the upper interface to those at the lower interface of any homogeneous layer can be derived based on the state equations. Combined with the interface continuity condition, the static response can be obtained by imposing the sinusoidal load on the top surfaces of laminates. Finally, the numerical examples are presented to verify the effectiveness of this method, and the results are very useful for the design and understanding of the characterization of FG QC materials in their applications to multilayered systems.
- Published
- 2021
8. Potential correlation of allograft infiltrating group 2 innate lymphoid cells with acute rejection after liver transplantation
- Author
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Jie, Sun, Guang-Peng, Zhou, Shi-Peng, Li, Xiao-Jie, Chen, Jin-Ming, Zhang, Yi-Zhou, Jiang, Bin, Cui, Hai-Ming, Zhang, Li-Ying, Sun, and Zhi-Jun, Zhu
- Subjects
Graft Rejection ,Mice ,Immunology ,Animals ,Immunology and Allergy ,Lymphocytes ,Allografts ,Immunity, Innate ,Liver Transplantation - Abstract
Accumulating evidence indicates the critical roles of group 2 innate lymphoid cells (ILC2s) in immunoregulation. However, the role of ILC2s in acute rejection after liver transplantation (LT) remains elusive. In this study, we analyzed the frequency, counts, and signature cytokines of ILC2s in liver transplant recipients by flow cytometric analysis and multiplex immunofluorescence assay. We also assessed the spatial distribution and correlation between hepatic ILC2s and Treg cells. The changes of ILC2s were dynamically monitored in the mouse LT model. We found that the frequencies of circulating ILC2s were comparable in liver transplant recipients with either rejection or non-rejection compared with the control group. The hepatic ILC2s counts were significantly increased in the rejection group than in the non-rejection and control groups, and a similar trend was observed for Treg cells. In the mouse LT model, allograft infiltrating ILC2s dramatically increased within 14 days post-transplant. The frequency of ILC2s in bone marrow significantly increased at 7 days post-transplant and rapidly decreased at 14 days after LT. Similarly, there was a significant increase in the frequency of splenic ILC2s within two weeks post-transplant. Multiplex immunofluorescence assay showed a close correlation between hepatic ILC2s and Treg cells by analyzing their spatial distribution and distance. In conclusion, the number of allograft infiltrating ILC2s was closely related to rejection after LT. Allograft infiltrating ILC2s may play inhibitory roles in posttransplant immune homeostasis, favoring resolution of liver allograft rejection by interacting with Treg cells or promoting the migration of Tregs cells into the liver allograft.
- Published
- 2022
9. The efficacy of platelet rich plasma on anterior cruciate ligament reconstruction: a systematic review and meta-analysis
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Jin-Ming Zhang, Zhi-Ying Pang, Jun-Ming Huang, Zheng-tao Lv, Wen-tao Zhu, and Zhe Wang
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medicine.medical_specialty ,Anterior Cruciate Ligament Reconstruction ,Anterior cruciate ligament reconstruction ,Platelet-Rich Plasma ,business.industry ,musculoskeletal, neural, and ocular physiology ,Anterior cruciate ligament ,medicine.medical_treatment ,Hematology ,General Medicine ,musculoskeletal system ,medicine.disease ,Risk Assessment ,Surgery ,surgical procedures, operative ,medicine.anatomical_structure ,Meta-analysis ,Platelet-rich plasma ,medicine ,Musculoskeletal injury ,Humans ,Platelet ,business ,human activities - Abstract
Anterior cruciate ligament (ACL) rupture is a common musculoskeletal injury, most frequently affecting young and physically active patients. Platelet-rich plasma (PRP) has been widely used in ACL reconstruction to augment the graft healing. However, high-level studies addressing its clinical efficacy could not reach a consensus. In this study, we assess the efficacy of PRP on pain relief, functional improvement along with radiological changes in patients who underwent ACL reconstruction. We performed comprehensive literature search and included 17 RCTs containing 970 participants who underwent ACL reconstruction. The combined data showed significant difference between PRP and control with regard to VAS score (MD: -1.12, 95% CI -1.92, -0.31
- Published
- 2021
10. Ketone Body Rescued Seizure Behavior of LRP1 Deficiency by Modulating Glutamate Transport
- Author
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Jin-Ming Zhang, Ming-Jie Chen, Jiong-Hui He, Ya-Ping Li, Zhi-Cai Li, Zi-Jing Ye, Yong-Hui Bao, Bing-Jun Huang, Wen-Jie Zhang, Ping Kwan, Yu-Ling Mao, and Jing-Da Qiao
- Subjects
fungi - Abstract
LRP1, the low-density lipoprotein receptor 1, would be a novel candidate epilepsy gene according to our bioinformatic results and the animal study. In this study, we explored the role of LRP1 in Epilepsy and whether Beta-hydroxybutyrate, the principal ketone body of the ketogenic diet can treat epilepsy caused by LRP1 deficiency. UAS/GAL4 system was used to establish different genotype models. Flies were given Standard, High-sucrose, and ketone body food randomly. The bang-sensitive test was performed on flies and seizure-like behavior was assessed. Morphologic alteration of LRP1 defect in the brain was detected under GPF expression flies. We established global, astrocytic, and neuronal LRP1 knockdown flies. Whole body and glia LRP1 defect flies had a higher seizure rate compared to the control group in the behavior test. Ketone body decreased the seizure rate in behavior test in all LRP1 defect flies, compared to Standard and High sucrose diet. In morphologic experiments, we found that LRP1 deficiency caused partial loss of the ellipsoidal body and partial destruction of the fan-shaped body. Overexpression of glutamate transporter gene Eaat1 could mimic the ketone body effect on LRP1 deficiency flies. This study demonstrated that LRP1 defect globally or in astrocytes or neurons could induce epilepsy. The ketone body efficaciously rescued epilepsy caused by LRP1 knockdown. The results support screening for LRP1 mutations as discriminating conduct for individuals who require clinical attention and further clarify the mechanism of the ketogenic diet in Epilepsy, which could help Epilepsy patients making a precise treatment case by case.
- Published
- 2022
11. Characteristics of changes in double positive CD4
- Author
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Shi-Peng, Li, Jin-Ming, Zhang, Xiao-Jie, Chen, Guang-Peng, Zhou, Jie, Sun, Bin, Cui, Liu-Xin, Zhou, Hai-Ming, Zhang, Wei-Tao, Que, Li-Ying, Sun, and Zhi-Jun, Zhu
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CD4-Positive T-Lymphocytes ,Graft Rejection ,Mice ,Programmed Cell Death 1 Receptor ,Animals ,CD8-Positive T-Lymphocytes ,T-Lymphocytes, Regulatory ,Liver Transplantation - Abstract
Although double positive CD4
- Published
- 2022
12. pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide
- Author
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Jia, Xin Li, Meng, Jiao Zhang, Jin, Feng Shi, Sheng, Peng Wang, Xue, Mei Zhong, Yi, Han Wu, Yan, Qu, Hui, Le Gao, and Jin, Ming Zhang
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Pharmaceutical Science - Abstract
Since pro-inflammatory macrophages take on a critical significance in the pathophysiology of rheumatoid arthritis (RA), the therapeutics to affect macrophages may receive distinct anti-RA effects. However, the therapeutic outcomes are still significantly impeded, which is primarily due to the insufficient drug delivery at the arthritic site. In this study, the macrophage-targeting and pH stimuli-responsive nano-polyelectrolyte complexes were designed for the efficient targeted delivery of triptolide (TP/PNPs) on the arthritic site. The anionic and cationic amphiphilic copolymers, i.e., hyaluronic acid-g-vitamin E succinate (HA-VE) and the quaternized poly (β-amino ester) (QPBAE-C
- Published
- 2023
13. Ketone Body Rescued Seizure Behavior of LRP1 Deficiency in Drosophila by Modulating Glutamate Transport
- Author
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Jin-Ming Zhang, Ming-Jie Chen, Jiong-Hui He, Ya-Ping Li, Zhi-Cai Li, Zi-Jing Ye, Yong-Hui Bao, Bing-Jun Huang, Wen-Jie Zhang, Ping Kwan, Yu-Ling Mao, and Jing-da Qiao
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Cellular and Molecular Neuroscience ,Sucrose ,Epilepsy ,Seizures ,Animals ,Glutamic Acid ,Drosophila ,General Medicine ,Ketone Bodies - Abstract
LRP1, the low-density lipoprotein receptor 1, would be a novel candidate gene of epilepsy according to our bioinformatic results and the animal study. In this study, we explored the role of LRP1 in epilepsy and whether beta-hydroxybutyrate, the principal ketone body of the ketogenic diet, can treat epilepsy caused by LRP1 deficiency in drosophila. UAS/GAL4 system was used to establish different genotype models. Flies were given standard, high-sucrose, and ketone body food randomly. The bang-sensitive test was performed on flies and seizure-like behavior was assessed. In morphologic experiments, we found that LRP1 deficiency caused partial loss of the ellipsoidal body and partial destruction of the fan-shaped body. Whole-body and glia LRP1 defect flies had a higher seizure rate compared to the control group. Ketone body decreased the seizure rate in behavior test in all LRP1 defect flies, compared to standard and high sucrose diet. Overexpression of glutamate transporter gene Eaat1 could mimic the ketone body effect on LRP1 deficiency flies. This study demonstrated that LRP1 defect globally or in glial cells or neurons could induce epilepsy in drosophila. The ketone body efficaciously rescued epilepsy caused by LRP1 knockdown. The results support screening for LRP1 mutations as discriminating conduct for individuals who require clinical attention and further clarify the mechanism of the ketogenic diet in epilepsy, which could help epilepsy patients make a precise treatment case by case.
- Published
- 2022
14. [UPLC fingerprint and determination of five components of substance benchmark of classical prescription Shentong Zhuyu Decoction]
- Author
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Lin, Wang, Yan-Ping, Jiang, Hua-Juan, Jiang, Yi, Chen, Xin, Nie, Xiu-Lan, Pu, Chen-Xi, Zhao, Zhi-Song, Yang, Jin-Ming, Zhang, and Chao-Mei, Fu
- Subjects
Quality Control ,Chromatography, High Pressure Liquid ,Drugs, Chinese Herbal - Abstract
Fingerprints of 18 batches of substance benchmark of Shentong Zhuyu Decoction(SZD) were established by UPLC under the following conditions: Waters Sun Fire C_(18) column(3.0 mm×150 mm, 3.5 μm), column temperature of 35 ℃, gradient elution with mobile phase of acetonitrile(A)-0.1% phosphoric acid aqueous solution(B) at the flow rate of 0.4 mL·min~(-1), and detection by wavelength switching. A total of 16 common peaks were identified. The similarities among the fingerprints were calculated by Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine(2012 Edition) and the result showed they were in the range of 0.911-0.988. Based on the 16 common peaks, cluster analysis(CA), principal component analysis(PCA), and partial least square discriminant analysis(PLS-DA) all categorized the 18 batches of samples into two groups(S1, S2, S5-S8, S14, and S17 in one group, and S1, S2, S5-S8, S14, and S17 in another), and 11 most influential components were screened. Five known components with great difference among samples(hydroxysafflor yellow A, ferulic acid, benzoic acid, ecdysone, and ammonium glycyrrhizinate) were determined. The combination of multi-component content determination and fingerprints can reflect the overall cha-racteristics of the primary standards of SZD, which is simple, feasible, reproducible, and stable. This study can serve as a reference for the quality control of the primary standards of SZD.
- Published
- 2022
15. Characteristic Changes of Double Positive CD4 + CD8 + T Cell in Liver Transplantation
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Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Haiming Zhang, Wei-Tao Que, Li-Ying Sun, and Zhijun Zhu
- Published
- 2022
16. Applications of Click Chemistry Reaction for Proteomics Analysis
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Jin-Ming Zhang, Si-Yu Gao, Yuan-Dong Xie, Yi Li, Ning Liu, and Fang-Ling Zhan
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Reaction mechanism ,Chemistry ,010401 analytical chemistry ,High selectivity ,Nanotechnology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Proteomics ,01 natural sciences ,Small molecule ,0104 chemical sciences ,Analytical Chemistry ,Structure and function ,Molecular level ,otorhinolaryngologic diseases ,Click chemistry ,0210 nano-technology - Abstract
Cu(I)-catalyzed azide-alkyne specific reaction, popularly known as the “click chemistry reaction”, is defined as an important molecular connection method, which can realize simple and efficient connection between specific small molecule groups at the molecular level. Because of its advantages such as high efficiency, high selectivity, mild conditions and few side reactions, click chemistry reaction has been widely used in proteomics analysis, including identification of newly synthesized proteins and the identification of various post-translational modified proteins. Therefore, in-depth study of the reaction mechanism of click chemistry reaction in proteomics is very important for understanding the structure and function of proteins. This review highlights the progress of several important applications of click chemistry in proteomics analysis in recent years, and discusses the future trends of the click chemistry in proteomics.
- Published
- 2020
17. A Near-Infrared Peptide Probe with Tumor-Specific Excretion-Retarded Effect for Image-Guided Surgery of Renal Cell Carcinoma
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Wanhai Xu, Lu Wang, Dayong Hou, Wu-Yi Xiao, Hong-Wei An, Wang Hao, Jiaqi Wang, Li-Ming Cheng, Man-Di Wang, Rui Zheng, Tong-Da Yan, Changhao Zhao, Xiang-Zhong Zeng, Jin-Ming Zhang, and Ziqi Wang
- Subjects
Cell Survival ,Infrared Rays ,Surface Properties ,Mice, Nude ,General Physics and Astronomy ,Peptide ,02 engineering and technology ,Signal-To-Noise Ratio ,010402 general chemistry ,01 natural sciences ,Lesion ,Mice ,Renal cell carcinoma ,Cell Line, Tumor ,medicine ,Animals ,Humans ,General Materials Science ,Particle Size ,Carcinoma, Renal Cell ,Fluorescent Dyes ,chemistry.chemical_classification ,Mice, Inbred BALB C ,Kidney ,Tumor microenvironment ,business.industry ,Optical Imaging ,General Engineering ,021001 nanoscience & nanotechnology ,medicine.disease ,Kidney Neoplasms ,0104 chemical sciences ,Image-guided surgery ,medicine.anatomical_structure ,Surgery, Computer-Assisted ,chemistry ,Cancer cell ,Cancer research ,Female ,medicine.symptom ,Peptides ,0210 nano-technology ,business ,Ex vivo - Abstract
Image-guided surgery plays a crucial role in realizing complete tumor removal, reducing postoperative recurrence and increasing patient survival. However, imaging of tumor lesion in the typical metabolic organs, e.g., kidney and liver, still has great challenges due to the intrinsic nonspecific accumulation of imaging probes in those organs. Herein, we report an in situ self-assembled near-infrared (NIR) peptide probe with tumor-specific excretion-retarded (TER) effect in tumor lesions, enabling high-performance imaging of human renal cell carcinoma (RCC) and achieving complete tumor removal, ultimately reducing postoperative recurrence. The NIR peptide probe first specifically recognizes αvβ3 integrin overexpressed in renal cancer cells, then is cleaved by MMP-2/9, which is up-regulated in the tumor microenvironment. The probe residue spontaneously self-assembles into nanofibers that exhibit an excretion-retarded effect in the kidney, which contributes to a high signal-to-noise (S/N) ratio in orthotopic RCC mice. Intriguingly, the TER effect also enables precisely identifying eye-invisible tiny lesions (
- Published
- 2020
18. The Lark Loop Used for Proximal Biceps Tenodesis: An All-Arthroscopic Technique
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Min Zhou, Chuan-Hai Zhou, Jin-Ming Zhang, Long Yi, Jiang Guo, Jing-Yi Hou, and Rui Yang
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Orthopedics and Sports Medicine - Abstract
Long head of the biceps tendinopathy is a common shoulder problem that is difficult to diagnose and treat. Biceps tenodesis is an effective surgical approach target for long head of the biceps tendon lesions. This article describes an all-arthroscopic proximal biceps tenodesis technique. This technique uses a high-strength suture to construct a tear-resistant loop; fixation is achieved with a suture anchor at the proximal aspect of the intertubercular groove or the greater tuberosity. This tenodesis fixation is simple, with no neurovascular injury or humeral fracture risk. In addition, our technique is cost-effective, with no need for specialty sutures.
- Published
- 2021
19. BRCC36 promotes intestinal mucosal barrier injury caused by BMP2 after ischemia reperfusion via inhibiting PPARγ signaling
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Jin-Ming Zhang, Kun-Nan Wang, Yun Zhang, Jun-Ze Zhang, Xin-Pu Yuan, Gui-Jun Zou, Zhen Cao, and Chao-Jun Zhang
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PPAR gamma ,Organic Chemistry ,General Medicine ,Molecular Biology ,Applied Microbiology and Biotechnology ,Biochemistry ,Analytical Chemistry ,Biotechnology - Abstract
As one of the most common pathological changes in trauma and surgery practice, intestinal ischemia-reperfusion (I/R) injury is regarded as a major precipitating factor in the occurrence and development of fatal diseases. BRCA1–BRCA2-containing complex subunit 36 (BRCC36), a deubiquitinase, has been proved important in a variety of pathophysiological processes such as DNA repair, cell cycle regulation, tumorigenesis, and inflammatory response. However, the effect of BRCC36 on intestinal mucosal barrier injury after I/R has not been fully elucidated. Our research found that BRCC36 aggravated intestinal mucosal barrier injury caused by bone morphogenetic protein 2 after I/R by downregulating peroxisome proliferator-activated receptor-γ (PPARγ) signaling. These results suggested that BRCC36/PPARγ axis might serve as a potential therapeutic target for preventing intestinal mucosal barrier injury after I/R.
- Published
- 2021
20. [Mechanisms and application of triptolide against breast cancer]
- Author
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Jia-Xin, Li, Jin-Feng, Shi, Yi-Han, Wu, Hai-Ting, Xu, Chao-Mei, Fu, and Jin-Ming, Zhang
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Tumor Microenvironment ,Epoxy Compounds ,Humans ,Breast Neoplasms ,Female ,Diterpenes ,Phenanthrenes - Abstract
Overtaking lung cancer,breast cancer is now the most commonly diagnosed cancer seriously threatening peopleapos;s health and life. As the main effective component of Tripterygium wilfordii,triptolide( TP) has attracted increasing attention due to its multitarget and multi-pathway anti-tumor activity. Recent studies have revealed that breast cancer-sensitive TP enables the inactivation of breast cancer cells by inducing tumor cell apoptosis and autophagy,interfering in tumor cell metastasis,resisting drug resistance,arresting tumor cell cycle,and influencing tumor microenvironment. It has been recognized as a promising clinical antitumor agent by virtue of its widely accepted therapeutic efficacy. This paper reviewed the anti-breast cancer action and its molecular mechanisms of TP on the basis of the relevant literature in the past ten years,and proposed application strategies in view of the inadequacy of TP to provide a reference for further research on the application of TP in the treatment of breast cancer.
- Published
- 2021
21. 422.9: ILC2s Regulate Kupffer Cells Polarization to Alleviate Hepatic Ischemia-Reperfusion Injury via IL-4/JNK/STAT3 Pathway
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Xiao-Jie Chen, Hai-Ming Zhang, Shi-Peng Li, Jin-Ming Zhang, Bin Cui, Li-Ying Sun, and Zhi-Jun Zhu
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Transplantation - Published
- 2022
22. Characteristics of changes in double positive CD4+CD8+ T cells in liver transplantation
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Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, and Zhi-Jun Zhu
- Subjects
Pharmacology ,Immunology ,Immunology and Allergy - Published
- 2022
23. Pro-environment Cu2O facilitate stable low-wastage ultraviolet p-CuxO/n-GaN LEDs with virtual electron blocking nanolayer
- Author
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Hui Wang, Fei Fan Yang, Rong Li, Yi Jian Zhou, Wen Bo Peng, Guo Jiao Xiang, Jin Ming Zhang, Yue Liu, Jia Hui Zhang, Yang Zhao, and Zhi Feng Shi
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Electrical and Electronic Engineering ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2022
24. [Effect of urease/nitrification inhibitor on urea nitrogen conversion in black soil and cinnamon soil.]
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Xue-Hong, Li, Dong-Po, Li, Zhi-Jie, Wu, Lei, Cui, Fu-Rong, Xiao, Yong-Hua, Li, Ye, Zheng, and Jin-Ming, Zhang
- Subjects
China ,Soil ,Cinnamomum zeylanicum ,Nitrogen ,Urea ,Fertilizers ,Nitrification ,Urease - Abstract
We studied the effects of urease/nitrification inhibitor combinations on urea hydrolysis and nitrification, aiming to screen out the effective inhibitor combinations for black soil and cinnamon soil in Northeast China. Urease inhibitor, N-butyl thiophosphate-triamine (NBPT), and its combination with nitrification inhibitor dicyandiamide (DCD), 3, 4-dimethylpyrazole phosphate (DMPP), 2-chloro-6 (trichloromethyl)-pyridine (CP), 2-amino-4-chloro-6-methylpyrimidine (AM) and 3-methylpyrazole (MP) were added to urea separately. Samples were collected 15 times in each of all the treatments during 125 days. We examined the changes of urea nitrogen, ammo-nium, nitrate, and nitrification inhibition rate in the two soils. Our results showed the hydrolysis of urea in black soil and cinnamon soil was about 7 d, and the addition of NBPT with or without diffe-rent nitrification inhibitors slowed down the hydrolysis to 21 d at least. Compared with the treatment with common urea, inhibitor addition significantly increased soil NH本试验研究脲酶/硝化抑制剂不同组合在黑土和褐土中对尿素水解和硝化作用的调控效果,旨在筛选出适合东北黑土、褐土的高效抑制剂组合。采用室内恒温、恒湿培养试验,以不施氮肥(CK)和施用普通尿素肥料(U)为对照,研究分别添加脲酶抑制剂N-丁基硫代磷酰三胺(NBPT)及其与硝化抑制剂双氰胺(DCD)、3,4-二甲基吡唑磷酸盐(DMPP)、2-氯-6(三氯甲基)-吡啶(CP)、2-氨基-4-氯-6-甲基嘧啶(AM)、3-甲基吡唑(MP)组合制成的6种高效稳定性尿素在黑土和褐土中的尿素水解和氨氧化特征。在培养125 d内分别取土壤样品15次,通过测定2种土壤中尿素态氮、铵态氮和硝态氮含量,及氨氧化作用强度,计算硝化抑制率,确定最适合2种土壤的抑制剂或组合。结果表明: 尿素在黑土和褐土中水解时间约7 d,添加NBPT以及其与不同硝化抑制剂组合均能将尿素水解时间延长21 d以上。与U处理相比,添加抑制剂可显著增加土壤NH
- Published
- 2021
25. Lamb Wave Propagate in Two-Dimensional Piezoelectric Quasicrystal Multilayered Plates with Nonlocal Effect
- Author
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Lang-liang Zhang, Xin Feng, Yang Gao, and Jin-ming Zhang
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Physics ,Wave propagation ,Mathematical analysis ,Quasicrystal ,02 engineering and technology ,Orthotropic material ,01 natural sciences ,Condensed Matter::Materials Science ,020303 mechanical engineering & transports ,Lamb waves ,Exact solutions in general relativity ,0203 mechanical engineering ,Normal mode ,Dispersion relation ,0103 physical sciences ,010301 acoustics ,Eigenvalues and eigenvectors - Abstract
In this paper, an exact solution of the propagation of the Lamb wave in orthotropic, multilayered, two-dimensional decagonal piezoelectric quasicrystal plate with the size-dependent effect is presented. According to the elasto-dynamics basic equations of quasicrystal and nonlocal theory, the wave propagating characteristics in the plates are translated into the linear eigenvalue system by employing the pseudo-Stroh formalism. The general solutions along the thickness direction are utilized to obtain the propagator matrix which connects the physical variables on the lower and upper interfaces of each layer. We can obtain the total propagator matrix for the whole laminate, which the interface continuity conditions are employed. Furthermore, if we assume that the upper and surface traction of the laminate is free, the dispersion equation is obtained. Finally, typical numerical examples are presented to illustrate the marked influences of thickness ratios and nonlocal parameters on the dispersion relationship and mode shapes of the two-dimensional decagonal piezoelectric quasicrystal multilayered plates.
- Published
- 2021
26. Free Vibration Of Three-Dimensional Piezoelectric Cubic Quasicrystal Plates
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Zhong-hui Mao, Yang Gao, Liangliang Zhang, Xin Feng, and Jin-ming Zhang
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Vibration ,Coupling ,Condensed Matter::Materials Science ,Materials science ,Condensed matter physics ,Normal mode ,Phonon ,Electric field ,Stacking ,Phason ,Piezoelectricity - Abstract
This paper uses the state-space method to study the free vibration of cubic piezoelectric quasi-crystal plates. The variations of natural frequencies and mode shapes of different thicknesses and stacking sequences with imperfect interfaces are numerically investigated. The results show that the interface coefficients significantly affect the natural frequencies with particular orders. Modal shapes in different stacking sequences also exist imperfect interfaces effect, which can be used to design composite plates with well-arranged stacking sequences. It is worth noting that the electric-phason coupling effect and the effect of phonon-phason coupling on phonon, phason, and electric fields are discussed to reveal the unique physical phenomenon of quasi-crystals. This work could expand the understanding of piezoelectric quasi-crystals, primarily on wave behaviors, such as forced vibration and guided waves.
- Published
- 2021
27. Long non-coding RNA in osteogenesis
- Author
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Fengjing Guo, Jin-Ming Zhang, Xiaoxia Hao, M. Yin, and Tao Xu
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0303 health sciences ,Cell ,RNA ,Biology ,medicine.disease_cause ,Regenerative medicine ,Long non-coding RNA ,Cell biology ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Orthopedics and Sports Medicine ,Surgery ,Bone marrow ,Stem cell ,Induced pluripotent stem cell ,Carcinogenesis ,030304 developmental biology - Abstract
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides with limited coding potential, which have emerged as novel regulators in many biological and pathological processes, including growth, development, and oncogenesis. Accumulating evidence suggests that lncRNAs have a special role in the osteogenic differentiation of various types of cell, including stem cells from different sources such as embryo, bone marrow, adipose tissue and periodontal ligaments, and induced pluripotent stem cells. Involved in complex mechanisms, lncRNAs regulate osteogenic markers and key regulators and pathways in osteogenic differentiation. In this review, we provide insights into the functions and molecular mechanisms of lncRNAs in osteogenesis and highlight their emerging roles and clinical value in regenerative medicine and osteogenesis-related diseases. Cite this article: J. Zhang, X. Hao, M. Yin, T. Xu, F. Guo. Long non-coding RNA in osteogenesis: A new world to be explored. Bone Joint Res 2019;8:73–80. DOI: 10.1302/2046-3758.82.BJR-2018-0074.R1.
- Published
- 2019
28. Research on the Influence of Leadership Style on Error Management Climate
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Chong-li Wang, Jin-ming Zhang, and Qing-hua Li
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Error Management ,Applied psychology ,Leadership style ,Psychology - Published
- 2019
29. [Effects of high efficiency and stability ammonium sulfate fertilizer applied in black soil]
- Author
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Lei, Cui, Dong-Po, Li, Zhi-Jie, Wu, Xue-Hong, Li, Yong-Hua, Li, Zeng-Hui, Yan, Ye, Zheng, and Jin-Ming, Zhang
- Subjects
Soil ,Ammonium Sulfate ,Nitrogen ,Fertilizers ,Nitrification - Abstract
To develop high efficiency stabilized N fertilizer, a pot experiment was conducted to examine the effects of stabilized ammonium sulfate with different nitrification inhibitors on soil avai-lable nitrogen (N) contents, nitrification inhibition rate, apparent nitrification rate, yield, some agronomic parameters and N fertilizer utilization rate of corn in black soil of Jilin Provinve. In this study, blank (CK) and (NH为筛选高效稳定性氮肥,采用盆栽试验,通过监测施用不同处理的稳定性硫酸铵对黑土铵态氮和硝态氮含量、表观硝化率、硝化抑制率、玉米生长指标、产量和氮素效率等指标的影响,研究添加不同生化抑制剂配方的稳定性硫酸铵态氮肥在吉林黑土玉米栽培中的施用效果。本试验以不施氮肥(CK)和施硫酸铵(N)为对照,在硫酸铵中分别添加硝化抑制剂3,4-二甲基吡唑磷酸盐(DMPP)、2-氯-6-三甲基吡啶(CP),氮保护剂(N-GD)和肥料增效剂(HFJ)及其组合,制成9种稳定性硫酸铵氮肥。结果表明: 与单施硫酸铵氮肥处理相比,在黑土中添加DMPP和DMPP组合显著影响土壤中铵态氮和硝态氮含量及土壤表观硝化率,铵态氮含量提高1.4~2.0倍,硝态氮含量降低13.6%~17.9%,土壤表观硝化率降低55.3%~59.8%;添加DMPP、DMPP+HFJ和DMPP+N-GD组合硝化抑制率最高,达到16.5%以上;添加DMPP+HFJ+N-GD和HFJ的硫酸铵处理玉米叶片叶绿素含量增加最显著,增加4.5~5.3倍;硫酸铵添加硝化抑制剂和肥料增效剂对株高无显著影响;添加HFJ的硫酸铵处理玉米生物量、籽粒产量、经济系数、收获指数、氮肥农学利用率、氮素吸收利用率、肥料贡献率和氮肥偏生产力增加最显著,分别增加1.2、2.5、0.7、0.6、2.7、2.1、1.3和2.5倍。添加HFJ和DMPP、DMPP+HFJ、DMPP+N-GD处理的硫酸铵处理在黑土中施用效果最好,但是DMPP成本较高,因此,兼顾成本和氮肥利用率,建议稳定性硫酸铵态氮肥生化抑制剂首选氮肥增效剂HFJ,其次选择DMPP+HFJ或者DMPP+N-GD。.
- Published
- 2020
30. [Evaluation of chemical quality profile of Polygoni Multiflori Radix at different processing degrees based on its classic processing method 'nine-steaming and nine-sun-curing']
- Author
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Yan-Fen, Cheng, Xin, Nie, Rui, Tan, Liang, Zhang, Yi-Han, Wu, Jin-Ming, Zhang, and Chao-Mei, Fu
- Subjects
Steam ,Polysaccharides ,Phytochemicals ,Stilbenes ,Discriminant Analysis ,Technology, Pharmaceutical ,Anthraquinones ,Glycosides ,Polygonum ,Least-Squares Analysis ,Plant Roots ,Chromatography, High Pressure Liquid ,Drugs, Chinese Herbal - Abstract
Based on the ancient method of nine-steaming and nine-sun-curing,the chemical composition changes and quality profiles in different processes of Polygoni Multiflori Radix were studied. Their contents of stilbene glycoside,anthraquinones and polysaccharides were determined by nine-steaming and nine-sun-curing with black bean juice and pharmacopoeia method. HPLC chemical fingerprints were established,and orthogonal partial least squares-discriminant analysis( OPLS-DA) was performed on different processed products using SIMCA 14. 1 software to evaluate the quality difference between samples. The results of content determination show that,with the increase of the number of processing and steaming times,the stilbene glycoside and the combined anthraquinone showed a decreasing trend,and the free anthraquinone,total anthraquinone and polysaccharide showed an upward trend in the different preparations of Polygoni Multiflori Radix and Pharmacopoeia. Six-steamed and six-sun-cured products can be used as the finishing point for the classic steaming. Fingerprint results showed that there were significant differences in chemical composition in Polygoni Multiflori Radix at different processing processes. It can be identified stilbene glycoside( peak 13),emodin( peak 21),and physcion( peak 24). By comparing the relative peak areas of the 26 chromatographic peaks in the sample after normalization( the reference is peak 7),it was found that the relative peak areas of 12 peaks in the processed products were higher than the raw products,13 peaks were reduced; according to statistical analysis of OPLS-DA,Polygoni Multiflori Radix at different processing degrees was further divided into three categories,sample S1 was class I,S2-S5 were class Ⅱ,and S6-S11 were class Ⅲ. And 8 peaks with the VIP value higher than 1. 0 were peak 13,21,4,3,11,14,5,and 24 in order. The eight chemical components were the main components to distinguish the difference between Polygoni Multiflori Radix in the process of nine-steaming and nine-sun-curing,suggesting that it was rational to use stilbene glycoside,emodin and emodin methyl ether as quality control indicators of Polygoni Multiflori Radix. The method established in this experiment conformed to the methodological verification requirements,established a method of multi-component content determination combined with fingerprint,and clarified that six-steaming and six-sun-curing was used as an improved classical processing technology,and more clearly defined the whole dynamic change of chemical composition in Polygoni Multiflori Radix by nine-steaming and ninesun-curing process. It provides a basis for the chemical quality evaluation model about different processed products of Polygoni Multiflori Radix.
- Published
- 2020
31. [Research progress on triptolide functionalized nanoparticulate drug delivery systems for tumor treatment]
- Author
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Yao-Yao, Luo, Jin-Feng, Shi, Liang, Chen, Jia-Xin, Li, Xiu-Ying, Ma, Jin-Ming, Zhang, and Fu-Neng, Geng
- Subjects
Drug Delivery Systems ,Epoxy Compounds ,Humans ,Nanoparticles ,Diterpenes ,Phenanthrenes - Abstract
Nowadays,the advantages of traditional Chinese medicine(TCM) for treatment of tumors are increasingly prominent.Triptolide shows wide-spectrum and highly effective anti-tumor activity. Moreover,nano-carrier-based triptolide drug delivery system is more powerful in improving water solubility and pharmacokinetic behavior of the drug,but it is easy to cause toxic and side effects that should not be neglected on human body. Because of tumor vascular heterogeneity and PEGylation dilemma,nanoparticulate drug delivery systems need to overcome multiple physiological and pathological barriers from drug administration to functioning. It is difficult for traditional triptolide nanoparticulate drug delivery systems to achieve active accumulation of nano-drug in tumor tissues and specific drug release in tumor target site solely relying on enhanced permeability and retention effect of solid tumor,limiting their application and clinical transformation in treatment of tumors. Based on the traditional nano-preparation system,the new functionalized nano-drug delivery system further enhances the nano-drug enrichment,penetration and controlled release at the tumor sites,which is of great significance in improving bioavailability,anti-tumor efficacy and reducing the side effects of drugs. In this paper,we summarized and analyzed the researches on new triptolide functionalized nano-drug delivery system from four perspectives,including tumor active targeting,tumor microenvironment response,polymer-drug conjugates,and multidrug co-delivery for tumor treatment,expecting to provide ideas for in-depth research and clinical application of triptolide and some other active anti-tumor TCM ingredients.
- Published
- 2019
32. Free Vibration of Functionally Graded One-Dimensional Hexagonal Piezoelectric Quasicrystal Sandwich Plates
- Author
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Yang Gao, Yunzhi Huang, Jin-ming Zhang, and Yang Li
- Subjects
Materials science ,Condensed matter physics ,Hexagonal crystal system ,Plane (geometry) ,Composite number ,Quasicrystal ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Piezoelectricity ,Vibration ,020303 mechanical engineering & transports ,0203 mechanical engineering ,Perpendicular ,0210 nano-technology - Abstract
A one-dimensional (1D) quasicrystal (QC) [1] refers to a three-dimensional structure with atomic arrangement quasi-periodically in one direction and periodically in the plane perpendicular to that direction [2] , [3] . Functionally graded martial (FGM) [4] – [10] composite piezoelectric QCs and other materials expand the application of QCs [11] – [13] .
- Published
- 2019
33. [Research progress on anti-tumor effects and mechanisms of triptolide and its combined application]
- Author
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Jin-Feng, Shi, Yao-Yao, Luo, Jia-Xin, Li, Rui-Feng, Luo, Liang, Chen, Jie, Li, Jin-Ming, Zhang, and Chao-Mei, Fu
- Subjects
Tripterygium ,Neoplasms ,Autophagy ,Epoxy Compounds ,Humans ,Apoptosis ,Cell Cycle Checkpoints ,Diterpenes ,Phenanthrenes ,Antineoplastic Agents, Phytogenic - Abstract
Tumors are major chronic diseases and seriously threaten human health all over the world. How to effectively control and cure tumors is one of the most pivotal problems in the medical field. At present,surgery,radiotherapy and chemotherapy are still the main treatment methods. However,the side effects of radiotherapy and chemotherapy cannot be underestimated. Therefore,it is of great practical significance to find new anti-cancer drugs with low toxicity,high efficiency and targeting to cancer cells. With the increasing incidence of tumor,the anti-tumor effect of traditional Chinese medicine has increasingly become a research hotspot. Triptolide,which is a natural diterpenoid active ingredient derived from of Tripterygium wilfordii,as one of the highly active components,has anti-inflammatory,immunosuppressive,anti-tumor and other multiple effects. A large number of studies have confirmed that it has good anti-tumor activity against various tumors in vivo and in vitro. It can play an anti-tumor role by inhibiting the proliferation of cancer cells,inducing apoptosis of cancer cells,inducing autophagy of cancer cells,blocking the cell cycle,inhibiting the migration,invasion and metastasis of cancer cells,reversing multidrug resistance,mediating tumor immunity and inhibiting angiogenesis. On the basis of literatures,this paper reviews the anti-tumor effect and mechanism of triptolide,and analyzes the current situation of triptolide combined with other chemotherapy drugs,in order to promote deep research and better clinical application about triptolide.
- Published
- 2019
34. Nrf2 is crucial for the down-regulation of Cyp7a1 induced by arachidonic acid in Hepg2 cells
- Author
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Li-hong Hao, Ishfaq Muhammad, Jin-ming Zhang, Guang-liang Li, Yue Qi, Xiuying Zhang, Xing-he Wang, Xiaoqi Sun, and He Wang
- Subjects
0301 basic medicine ,Cell Survival ,NF-E2-Related Factor 2 ,Health, Toxicology and Mutagenesis ,Cell ,Down-Regulation ,Biology ,Toxicology ,Cholesterol 7 alpha-hydroxylase ,digestive system ,environment and public health ,03 medical and health sciences ,chemistry.chemical_compound ,Downregulation and upregulation ,Western blot ,Transcription (biology) ,medicine ,Humans ,Gene silencing ,Gene Silencing ,RNA, Messenger ,Cholesterol 7-alpha-Hydroxylase ,Pharmacology ,Arachidonic Acid ,medicine.diagnostic_test ,Hep G2 Cells ,General Medicine ,respiratory system ,Molecular biology ,030104 developmental biology ,medicine.anatomical_structure ,Biochemistry ,chemistry ,Hepg2 cells ,Arachidonic acid - Abstract
In former research, cyp7a1 expression was decreased but Nrf2 transcription and hepatic arachidonic acid (AA) concentration were increased in high-fat diet fed mice. This study aims to investigate the influence of AA in CYP7A1 expression and the role of Nrf2 in regulating CYP7A1 in the process. HepG2 cells were administered with different concentrations of AA. Nrf2 and CYP7A1 expressions were analyzed by real-time PCR and western blot. Nrf2 silenced and over-expressed cell models were constructed by Nrf2 siRNA and eukaryotic expression vector transient transfections and were used to investigate the role of Nrf2 in regulating CYP7A1 following AA administration. The results showed that Nrf2 was increased dose-dependently but CYP7A1 was decreased dose-dependently in cells treated with increasing concentrations of AA. The expression of CYP7A1 was increased by Nrf2 silence and was decreased by Nrf2 over-expression in HepG2 cells treated with different concentrations of AA. In conclusion, Nrf2 plays a significant role in the down-regulation of CYP7A1 induced by AA in HepG2 cells.
- Published
- 2017
35. Research on Arm Shape of Manipulator Based on Trajectory and End Posture
- Author
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Jin-ming Zhang, Han-bo Zhang, and Yong-qiu Chen
- Subjects
business.industry ,Computer science ,Robotics ,Workspace ,Kinematics ,Terminal (electronics) ,Control theory ,Trajectory ,Artificial intelligence ,business ,Representation (mathematics) ,MATLAB ,Engineering design process ,computer ,computer.programming_language - Abstract
In order to solve the problem of reasonable distribution of joint combination in the design process of manipulator. In the design of manipulator, the target trajectory of manipulator and the requirement of end attitude should be taken into account. By dividing the change of trajectory and terminal attitude according to the three components of X-Y-Z, the corresponding joint combination mode is given. The kinematics relation of the arm shape of the manipulator is established by using the D-H representation. The forward and inverse solutions are obtained by using the Robotics Toolbox in MATLAB, and the workspace is given. By checking whether there is a reasonable inverse solution to judge the appropriate joint combination mode, according to the change of the attitude at the end of the joint, it is increased according to the change of the posture at the end of the joint. Add the corresponding joint type to complete the target task. According to this method, the design idea of manipulator can be given clearly, which provides a reference for improving the rationality of manipulator joint combination.
- Published
- 2019
36. [Nitrogen transformation of stable ammonium fertilizer in black soil and cinnamon soil]
- Author
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Lun Cheng, You, Dong Po, Li, Zhi Jie, Wu, Lei, Cui, Zeng Hui, Yan, Jin Ming, Zhang, Yong Kun, Cui, and Yu, Liu
- Subjects
Soil ,Cinnamomum zeylanicum ,Nitrogen ,Ammonium Compounds ,Fertilizers ,Nitrification - Abstract
A chamber culture experiment was conducted to measure soil nitrogen transformation following application of stabilized ammonium fertilizers in black soil and cinnamon soil. There were three application levels (0.20, 0.50, 1.00 g N·kg以稳定性氯化铵为氮源,采用室内培养的方法,研究0.20、0.50、1.00 g N·kg
- Published
- 2019
37. Research on An Method of Muscle Force Prediction Based on Dynamic Fuzzy Neural Network
- Author
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Yao Wenxuan, Yi-hao Du, Ping Xie, Shi Qiu, Jin-Ming-Zhang, Hao Wang, Zhang Ningning, and Xie Boduo
- Subjects
medicine.anatomical_structure ,Artificial neural network ,Computer science ,Control theory ,Elbow ,medicine ,Rehabilitation evaluation ,Elbow angle ,Energy source ,Biceps ,Muscle force - Abstract
Muscle force is the energy source of human body motion. It is not only the basic data basis for the rehabilitation evaluation of human motor function, but also can provide a theoretical basis for the control of rehabilitation robots and the design of bionic joints. However, muscle force cannot be measured directly. Therefore, this paper combines the surface electromyogram(sEMG) with the joint angle, and propose a method of muscle force prediction based on dynamic fuzzy neural network (D-FNN). Firstly, subjects were required to perform flexion and extension of elbow movement in uniform speed and the time domain characteristics were extracted from the sEMG of subjects' biceps brachii. The elbow angle was collected at the same time. Next, the contraction force of the biceps brachii was obtained based on the OpenSim platform which can used to simulate human motion. Then, based on D-FNN, the mapping from sEMG and elbow angle to muscle force were obtained. Finally, the effectiveness of the method was verified by experiments.
- Published
- 2018
38. A Musculoskeletal Model of Upper Limb for Disabled Extremity
- Author
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Hao Wang, Ping Xie, Zhang Ningning, Yao Wenxuan, Yi-hao Du, Shi Qiu, Xie Boduo, and Jin-Ming Zhang
- Subjects
0209 industrial biotechnology ,medicine.medical_specialty ,Rehabilitation ,business.industry ,medicine.medical_treatment ,020208 electrical & electronic engineering ,02 engineering and technology ,Rehabilitation robot ,020901 industrial engineering & automation ,medicine.anatomical_structure ,Physical medicine and rehabilitation ,Biological structure ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Upper limb ,business - Abstract
In this paper, we propose a new musculoskeletal model (MSM) that can directly act on disabled extremities according to different stages of rehabilitation. Firstly, we build an upper limb MSM of health extremity. Then we calculate the torque generated by the health extremity, next considering the biological structure of the disabled extremity is the same as that of the health extremity, we use the principle of mirror image to mirror the torque generated by health extremity and the parameters of it to disabled extremity. Finally, according to physiology and Manual Muscle Test (MMT), we re-optimize the selected parameters in MSM to fit the real-condition of disabled extremity. The result exhibit that the MSM of disabled extremity is able to exhibit the ability of disabled extremity. In the next study, we will try to introduce it into rehabilitation robot control.
- Published
- 2018
39. Retraction: miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling
- Author
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Wanhai Xu, Bo-Sen You, Yan Li, Wei Zhang, Zhong Qing Liu, Keliang Wang, Danfeng Zhao, Ruizhe Fang, Jiaqi Wang, Jin-Ming Zhang, Lu Wang, and Zhichao Wang
- Subjects
Male ,MAPK/ERK pathway ,Aging ,MAP Kinase Signaling System ,Antineoplastic Agents ,MMP9 ,Metastasis ,Mice ,Prostate cancer ,chemistry.chemical_compound ,In vivo ,Nitriles ,Phenylthiohydantoin ,medicine ,Animals ,Humans ,Enzalutamide ,Neoplasm Metastasis ,Mice, Inbred BALB C ,Gene knockdown ,Chemistry ,Cell Biology ,medicine.disease ,Survival Analysis ,Xenograft Model Antitumor Assays ,Retraction ,Androgen receptor ,Alternative Splicing ,MicroRNAs ,Prostatic Neoplasms, Castration-Resistant ,Matrix Metalloproteinase 9 ,Drug Resistance, Neoplasm ,Receptors, Androgen ,Trypsin Inhibitor, Kazal Pancreatic ,Benzamides ,Cancer research ,Mitogen-Activated Protein Kinases ,Signal Transduction - Abstract
Whether serine protease inhibitor Kazal type 1 (SPINK1) being associated with enzalutamide (Enz) resistance and metastasis of castration-resistant prostate cancer (CRPC) has not been clear. SPINK1 promoted Enz resistance by upregulating Androgen receptor splicing variant 7 (ARv7), and enhanced the invasion/migration of Enz-resistant cells via ERK/p38/ MMP9 signaling. Furthermore, miR-5089-5p suppressed SPINK1 mRNA through direct binding to its 3'UTR, and reversed its pro-proliferative and pro-metastatic effects. Mice bearing SPINK1-knockdown Enz-resistant PCa tumors showed significantly longer survival compared with those bearing wild-type tumors, while treatment with miR-5089-5p inhibitor abrogated the protective effects of SPINK1 knockdown. Taken together, SPINK1 can be used as a biomarker of resistance to Enz, and the miR-5089-5p/SPINK1/MAPK/MMP9 axis is a suitable therapeutic target against Enz-resistant and metastatic CRPC.Methods: The expression of SPINK1 in Enz-resistant prostate cancer (PCa) cell lines was detected through next-generation sequencing data and metastatic PCa patients. In vivo and in vitro experiments were performed to investigate the role of SPINK1 in Enz-resistance and metastasis.
- Published
- 2020
40. Fractional S-transform-part 2: Application to reservoir prediction and fluid identification
- Author
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Zheng-Cong Du, De-Ping Xu, and Jin-Ming Zhang
- Subjects
Data processing ,020206 networking & telecommunications ,02 engineering and technology ,010502 geochemistry & geophysics ,01 natural sciences ,Domain (mathematical analysis) ,Fractional Fourier transform ,Field (computer science) ,Matrix decomposition ,Geophysics ,Shadow ,0202 electrical engineering, electronic engineering, information engineering ,Calculus ,FastICA ,Algorithm ,S transform ,Geology ,0105 earth and related environmental sciences - Abstract
The fractional S-transform (FRST) has good time–frequency focusing ability. The FRST can identify geological features by rotating the fractional Fourier transform frequency (FRFTfr) axis. Different seismic signals have different optimal fractional parameters which is not conducive to multichannel seismic data processing. Thus, we first decompose the common-frequency sections by the FRST and then we analyze the low-frequency shadow. Second, the combination of the FRST and blind-source separation is used to obtain the independent spectra of the various geological features. The seismic data interpretation improves without requiring to estimating the optimal fractional parameters. The top and bottom of a limestone reservoir can be clearly recognized on the common-frequency section, thus enhancing the vertical resolution of the analysis of the low-frequency shadows compared with traditional ST. Simulations suggest that the proposed method separates the independent frequency information in the time–fractional-frequency domain. We used field seismic and well data to verify the proposed method.
- Published
- 2016
41. Crosstalk between ATF4 and MTA1/HDAC1 promotes osteosarcoma progression
- Author
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Mi Li, Caihong Yang, Qian Chu, Zhuo Cai, Jiang Wang, Yu Du, Ye Ren, Jin-ming Zhang, Hao Li, and Heng Zeng
- Subjects
Male ,0301 basic medicine ,Lung Neoplasms ,Transcription, Genetic ,metastasis-associated protein 1 ,Apoptosis ,Histone Deacetylase 1 ,Metastasis ,Immunoenzyme Techniques ,Mice ,0302 clinical medicine ,Cell Movement ,Tumor Cells, Cultured ,Medicine ,Mice, Inbred BALB C ,Gene knockdown ,Reverse Transcriptase Polymerase Chain Reaction ,Prognosis ,Survival Rate ,Oncology ,030220 oncology & carcinogenesis ,Disease Progression ,Osteosarcoma ,Research Paper ,Chromatin Immunoprecipitation ,Blotting, Western ,Mice, Nude ,Bone Neoplasms ,Activating Transcription Factor 4 ,Real-Time Polymerase Chain Reaction ,Histone Deacetylases ,03 medical and health sciences ,Downregulation and upregulation ,osteosarcoma ,Animals ,Humans ,Immunoprecipitation ,RNA, Messenger ,Cell Proliferation ,Neoplasm Staging ,business.industry ,Cell growth ,ATF4 ,Ubiquitination ,medicine.disease ,Xenograft Model Antitumor Assays ,Repressor Proteins ,030104 developmental biology ,Cell culture ,Trans-Activators ,Cancer research ,business ,Follow-Up Studies - Abstract
The stress response gene activating transcription factor 4 (ATF4) is involved in metastatic behavior and cellular protection. Here we show that ATF4 is upregulated in osteosarcoma (OS) cell lines and patient clinical samples as compared to matched non-tumor tissue. Overexpression of ATF4 in OS cells promoted cell proliferation, migration and lung metastasis. Furthermore, the expression of ATF4 was markedly reduced in metastasis associated protein (MTA1) or histone deacetylase 1 (HDAC1) knockdown OS cells, but MTA1 overexpression increased the stability and activity of ATF4 protein via ATF4 deacetylation by HDAC1. ATF4 in turn enhanced the expression of MTA1 and HDAC1 at the transcription level, suggesting a positive feedback loop between ATF4 and MTA1/HDAC1. Clinically, the level of ATF4 was positively correlated with that of MTA1 in OS. Mice injected with ATF4-overexpressing cells exhibited a higher rate of tumor growth, and the average weight of these tumors was ~90% greater than the controls. Taken together, these data establish a direct correlation between ATF4-induced OS progression and MTA1/HDAC1-associated metastasis, and support the potential therapeutic value of targeting ATF4 in the treatment of OS.
- Published
- 2016
42. YAP and ERK mediated mechanical strain-induced cell cycle progression through RhoA and cytoskeletal dynamics in rat growth plate chondrocytes
- Author
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Jin-Ming Zhang, Yingxing Wu, Anmin Chen, Fengjing Guo, Yaping Ye, Kaixiang Yang, Hongbo You, Chengyuan Yang, Bin Pi, Jun Qi, Tao Xu, and Peng Cheng
- Subjects
0301 basic medicine ,MAPK/ERK pathway ,RHOA ,biology ,Cell cycle ,Microfilament ,Cell biology ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Orthopedics and Sports Medicine ,Mechanotransduction ,Cytoskeleton ,Tissue homeostasis ,Cytochalasin D - Abstract
Yes-associated protein (YAP) and extracellular signal-regulated kinase (ERK) have been considered as key regulators in tissue homeostasis, organ development, and tumor formation. However, the roles of YAP and ERK in the mediating strain mechanosensing in the growth plate cartilage have not been determined. In this study, chondrocytes obtained from the growth plate cartilage of 2-week-old Sprague-Dawley rats were subjected to the mechanical strain with different magnitudes and durations at a frequency of 0.5 Hz. We found that YAP and ERK activation in response to mechanical strain was time and magnitude dependent. Pretreatment with a RhoA inhibitor (C3 toxin) or a microfilament cytoskeleton disrupting reagent (cytochalasin D) could suppress their activation. In addition, activated YAP and ERK were able to induce cell cycle progression by up-regulating the expression of cell cycle-related genes. These results shed new light on the function of YAP and ERK in mechanical strain-promoted growth plate development. Our results also provided evidence that RhoA and cytoskeletal dynamics are required for this mechanotransduction. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1121-1129, 2016.
- Published
- 2016
43. Acupuncture Versus Non-Steroidal Anti-Inflammatory Drugs for Treatment of Chondromalacia Patellae: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Author
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Xiang Zhou, Jin-Ming Zhang, Zheng-tao Lv, Wen-Wen Ma, Anmin Chen, and Zhi-Qiang Li
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Rehabilitation ,business.industry ,medicine.medical_treatment ,Alternative medicine ,medicine.disease ,Chondromalacia patellae ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Complementary and alternative medicine ,Non steroidal anti inflammatory ,Randomized controlled trial ,law ,Meta-analysis ,Acupuncture ,medicine ,Acupuncture therapy ,Physical therapy ,030212 general & internal medicine ,business ,030217 neurology & neurosurgery - Abstract
This systematic review aims to evaluate the efficacy and safety of acupuncture therapy for treating patients with chondromalacia patellae compared to non-steroidal anti-inflammatory drugs (NSAID). Eight databases including PubMed, EMBASE, CENTRAL, ISI Web of Science, CNKI, Wanfang, VIP, and CBM were searched up to June 2016. Randomized controlled trials (RCT) assessing the efficacy of acupuncture therapy were identified. The patients in experimental groups had to be treated with acupuncture therapy, and the patients in control groups had to be treated with NSAID. The outcome measures included clinical efficacy rates or pain scores. A total of 7 studies met our inclusion criteria. We analyzed the data from these 7 RCT involving 707 participants. All included studies were judged to be at high risk for bias. Compared with NSAID, acupuncture could further improve the clinical efficacy rates (Risk Ratio 2.57; 95% confidence interval (CI) 2.02, 3.27) and pain scores (Mean Difference -1.49; 95% CI -2.37, -0.62). No study reported adverse events associated with acupuncture therapy. Based on the findings in the present review, acupuncture therapy is more effective than NSAID in improving clinical efficacy rates and pain scores. However, these results should be interpreted cautiously due to the poor overall methodological quality of the included trials. Additional studies with large-scale and rigorous experimental design are required.
- Published
- 2016
44. Update on the Clinical Effect of Acupuncture Therapy in Patients with Gouty Arthritis: Systematic Review and Meta-Analysis
- Author
-
Jin-Ming Zhang, Anmin Chen, Zheng-tao Lv, and Weiwei Lu
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,business.industry ,Alternative medicine ,MEDLINE ,lcsh:Other systems of medicine ,Review Article ,lcsh:RZ201-999 ,03 medical and health sciences ,0302 clinical medicine ,Complementary and alternative medicine ,Meta-analysis ,Acupuncture ,Acupuncture therapy ,Physical therapy ,Medicine ,In patient ,030212 general & internal medicine ,Gouty arthritis ,business ,Adverse effect - Abstract
Objective. The aim of this study is to evaluate the clinical efficacy and safety of acupuncture therapy in the treatment of acute gouty arthritis.Methods. A literature search of PubMed, EMBASE, ISI Web of Science, CENTRAL, and CNKI was conducted from the inception date of each database up to October 2015. Two investigators screened each article independently and were blinded to the findings of the other reviewer. Data was extracted according to the predetermined collection form. Meta-analysis was performed.Results. We analyzed data from 28 RCTs involving 2237 patients with gouty arthritis. Compared with conventional pharmacological treatments acupuncture was more effective in rendering patients free from symptoms after 24 hours, lowering serum urate, alleviating pain associated with gouty arthritis, and decreasing the ESR; regarding CRP, no statistically significant difference was found. In addition, the frequency of adverse events in acupuncture treatment was lower than that in control group.Conclusion. Based on the findings of our study, we cautiously suggest that acupuncture is an effective and safe therapy for patients with gouty arthritis. However, the potential beneficial effect of acupuncture might be overstated due to the methodological deficiency of included studies. High quality RCTs with larger scale are encouraged.
- Published
- 2016
45. Mechano-growth factor protects against mechanical overload induced damage and promotes migration of growth plate chondrocytes through RhoA/YAP pathway
- Author
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Jiachao Guo, Rui Wang, Xingzhi Jing, Yaping Ye, Jun-Ming Huang, Jin-Ming Zhang, Yuan Bao, and Fengjing Guo
- Subjects
0301 basic medicine ,RHOA ,Protective Agents ,Focal adhesion ,Rats, Sprague-Dawley ,03 medical and health sciences ,Paracrine signalling ,0302 clinical medicine ,Chondrocytes ,Downregulation and upregulation ,Cell Movement ,Animals ,Growth Plate ,Insulin-Like Growth Factor I ,Cytoskeleton ,Cells, Cultured ,Cell Proliferation ,Inflammation ,Gene knockdown ,biology ,Cell migration ,YAP-Signaling Proteins ,Cell Biology ,Cell biology ,Rats ,030104 developmental biology ,030220 oncology & carcinogenesis ,biology.protein ,Stress, Mechanical ,Wound healing ,Apoptosis Regulatory Proteins ,rhoA GTP-Binding Protein ,Signal Transduction - Abstract
Epiphyseal growth plate is highly dynamic tissue which is controlled by a variety of endocrine, paracrine hormones, and by complex local signaling loops and mechanical loading. Mechano growth factor (MGF), the splice variant of the IGF-I gene, has been discovered to play important roles in tissue growth and repair. However, the effect of MGF on the growth plate remains unclear. In the present study, we found that MGF mRNA expression of growth plate chondrocytes was upregulated in response to mechanical stimuli. Treatment of MGF had no effect on growth plate chondrocytes proliferation and differentiation. But it could inhibit growth plate chondrocytes apoptosis and inflammation under mechanical overload. Moreover, both wound healing and transwell assay indicated that MGF could significantly enhance growth plate chondrocytes migration which was accompanied with YAP activation and nucleus translocation. Knockdown of YAP with YAP siRNA suppressed migration induced by MGF, indicating the essential role of YAP in MGF promoting growth plate chondrocytes migration. Furthermore, MGF promoted YAP activation through RhoA GTPase mediated cytoskeleton reorganization, RhoA inhibition using C3 toxin abrogated MGF induced YAP activation. Importantly, we found that MGF promoted focal adhesion(FA) formation and knockdown of YAP with YAP siRNA partially suppressed the activation of FA kinase, implying that YAP is associated with FA formation. In conclusion, MGF is an autocrine growth factor which is regulated by mechanical stimuli. MGF could not only protect growth plate chondrocytes against damage by mechanical overload, but also promote migration through activation of RhoA/YAP signaling axis. Most importantly, our findings indicate that MGF promote cell migration through YAP mediated FA formation to determine the FA-cytoskeleton remodeling.
- Published
- 2017
46. Corrigendum: Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism
- Author
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Zhang-Feng Zhong, Hai-Bing Yu, Chun-Ming Wang, Wen-An Qiang, Sheng-Peng Wang, Jin-Ming Zhang, Hua Yu, Liao Cui, Tie Wu, De-Qiang Li, and Yi-Tao Wang
- Subjects
0301 basic medicine ,intrinsic/extrinsic apoptosis ,NF-κB ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Breast cancer ,breast cancer ,furanodiene ,multidrug resistance ,medicine ,Pharmacology (medical) ,Original Research ,Pharmacology ,Doxorubicin resistant ,cell apoptosis ,Mechanism (biology) ,Intrinsic apoptosis ,lcsh:RM1-950 ,medicine.disease ,Multiple drug resistance ,030104 developmental biology ,lcsh:Therapeutics. Pharmacology ,MCF-7 ,chemistry ,Apoptosis ,030220 oncology & carcinogenesis ,Cancer research - Abstract
Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-κB-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.
- Published
- 2017
47. Contents Vol. 23, 2016 · Inhalt Band 23, 2016
- Author
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Wen-Wen Ma, Jin-Ming Zhang, Anmin Chen, Zhi-Qiang Li, Petra Klose, Xiang Zhou, Zheng-tao Lv, Stefanie Joos, Roman Huber, and Beate Stock-Schröer
- Subjects
Complementary and alternative medicine - Published
- 2016
48. Continuous Prediction of Joint Angle of Lower Limbs from sEMG Signals
- Author
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Ping Xie, Shi Qiu, Hao Wang, Yi-hao Du, and Jin-Ming Zhang
- Subjects
Coupling ,Motion analysis ,medicine.diagnostic_test ,business.industry ,Computer science ,Electromyography ,Knee Joint ,Signal ,Least squares ,medicine ,Computer vision ,Artificial intelligence ,business ,Joint (geology) ,Extreme learning machine - Abstract
In order to realize the rehabilitation training of mirror movement in stroke patients, a new motion analysis method of EMG signal is proposed. First, surface electromyography (sEMG), hip joint and knee joint angles of 6 lower limb muscles are collected synchronously. Then, by introducing the coherence analysis and calculating the significant area index, the coupling relationship between the sEMG and the joint angle is quantitatively described, and the muscles of the most coupling relationship are set to the input channels of the model. Next, we introduce the least squares extreme learning machine algorithm based on golden section (GS-LSELM), and establish a nonlinear prediction model between sEMG and joint angle. Finally, the experimental results show that the proposed method can quickly build the model under different motion periods, and it could be used in the tracking control of the rehabilitation robot.
- Published
- 2017
49. [Dissolution behavior of Fuzi Lizhong pill based on simultaneous determination of two components in Glycyrrhizae Radix et Rhizoma]
- Author
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Mao-Yuan, Jiang, Zhen, Zhang, Jin-Feng, Shi, Jin-Ming, Zhang, Chao-Mei, Fu, Xia, Lin, and Yu-Mei, Liu
- Subjects
Solubility ,Plant Extracts ,Glycyrrhiza ,Diterpenes ,Plant Roots ,Chromatography, High Pressure Liquid ,Rhizome ,Drugs, Chinese Herbal - Abstract
To preliminarily investigate the dissolution behavior of Fuzi Lizhong pill, provide the basis for its quality control and lay foundation for
- Published
- 2017
50. Bias- and temperature-assisted trapping/de-trapping of ron degradation in D-mode AlGaN/GaN MIS-HEMTs on a Si substrate
- Author
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Edward Yi Chang, Ting-En Hsieh, Shi-Xuan Chen, Po-Chien Chou, Szu-Hao Chen, Jin-Ming Zhang, and Tian-Li Wu
- Subjects
010302 applied physics ,Materials science ,business.industry ,020208 electrical & electronic engineering ,Wide-bandgap semiconductor ,Electrical engineering ,Algan gan ,02 engineering and technology ,Trapping ,01 natural sciences ,Stress (mechanics) ,Si substrate ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Degradation (geology) ,Optoelectronics ,Step stress ,Peak value ,business - Abstract
In this study, we investigate the Ron degradation in D-mode AlGaN/GaN MIS-HEMTs on a Si substrate via an accelerated step stress at different temperatures. We have observed a three-phase Ron degradation behavior, which is highly correlated with a drain bias and back gate bias. First, the Ron degradation increases till a peak value when the drain bias increases. Second, when the drain bias increases further, the Ron degradation is reduced. Third, the Ron degradation slowly increases again. Ron degradation is characterized with different temperatures, the results show that 1) high temperature leads to a smaller Ron degradation compared to the result at room temperature and 2) high temperature shifts the peak of the Ron degradation at a lower drain bias. A possible mechanism that the trapping and de-trapping could occur due to the high temperature and high drain bias is proposed to explain the observed results.
- Published
- 2017
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