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Corrigendum: Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism
- Source :
- Frontiers in Pharmacology, Frontiers in Pharmacology, Vol 8 (2017)
- Publication Year :
- 2017
-
Abstract
- Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-κB-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future.
- Subjects :
- 0301 basic medicine
intrinsic/extrinsic apoptosis
NF-κB
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Breast cancer
breast cancer
furanodiene
multidrug resistance
medicine
Pharmacology (medical)
Original Research
Pharmacology
Doxorubicin resistant
cell apoptosis
Mechanism (biology)
Intrinsic apoptosis
lcsh:RM1-950
medicine.disease
Multiple drug resistance
030104 developmental biology
lcsh:Therapeutics. Pharmacology
MCF-7
chemistry
Apoptosis
030220 oncology & carcinogenesis
Cancer research
Subjects
Details
- ISSN :
- 16639812
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Frontiers in pharmacology
- Accession number :
- edsair.doi.dedup.....451dad62cc59694d42924a1b65387b05