1. Gene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP
- Author
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Gunther Glehr, Fong Chun Chan, Bastian von Tresckow, Michael Altenbuchinger, Heinz Haverkamp, Rainer Spang, Ron D. Jachimowicz, Andreas Engert, Martin-Leo Hansmann, Horst Müller, Wolfram Klapper, Peter Borchmann, Harald Stein, Christoph Thorns, Peter Möller, David W. Scott, Hans Christian Reinhardt, Thorsten Rehberg, Andreas Rosenwald, and Christian Steidl
- Subjects
0301 basic medicine ,BEACOPP ,Oncology ,Male ,Cancer Research ,Receptor, Platelet-Derived Growth Factor alpha ,Letter ,CD30 ,medicine.medical_treatment ,Medizin ,610 Medizin ,0302 clinical medicine ,Gene expression ,Antineoplastic Combined Chemotherapy Protocols ,polycyclic compounds ,Cancer microenvironment ,Hodgkin lymphoma ,Etoposide ,ddc:610 ,Hematology ,Middle Aged ,Hodgkin Disease ,Survival Rate ,Treatment Outcome ,Vincristine ,030220 oncology & carcinogenesis ,Cohort ,Female ,Risk assessment ,medicine.drug ,Adult ,medicine.medical_specialty ,Adolescent ,Ki-1 Antigen ,macromolecular substances ,PDGFRA ,03 medical and health sciences ,Bleomycin ,Young Adult ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Cyclophosphamide ,Neoplasm Staging ,business.industry ,Gene Expression Profiling ,Gene expression profiling ,030104 developmental biology ,ABVD ,Doxorubicin ,Procarbazine ,Prednisone ,Chemokine CCL17 ,business ,Transcriptome - Abstract
Classical Hodgkin Lymphoma (cHL) is a B cell-derived lymphoid malignancy, affecting 2.5–3/100,000 people per year. To date, in patients diagnosed with advanced cHL no reliable tool is able to—a priori—distinguish the subset of patients at high risk for relapse or refractory disease. Clinical risk indices for cHL, such as the International Prognostic Score (IPS), have not been successfully applied as a treatment decision tool in advanced stage cHL [1]. In this study we show, that a previously published gene expression-based predictor in advanced stage cHL patients treated with ABVD [2] does not prove prognostic in 401 BEACOPP-treated advanced stage cHL patients. Using transcriptome profiling, we identified however that three individual genes, PDGFRA, TNFRSF8 (encoding CD30) and CCL17 (encoding TARC), were significantly associated with progression-free survival (PFS) after multiple test correction in the BEACOPP-treated cohort, highlighting the potential of a modified gene expression profiling approach for pre-treatment risk assessment., Letter
- Published
- 2021