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2. Additional file 1 of Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood
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Sunny, Shadia Khan, Zhang, Hongmei, Mzayek, Fawaz, Relton, Caroline L., Ring, Susan, A. John Henderson, Ewart, Susan, Holloway, John W., and S. Hasan Arshad
- Abstract
Additional file 1. Table S1: List of CpGs (k = 96) showing in both consistent and opposite direction of associations of DNA-M at childhood with lung function trajectories childhood-to-young adulthood in males and females between the IOW cohort and ALSPAC. Table S2: DMRs (k = 33) for lung function trajectory in relation to childhood DNA-M identified by DMRcate (FDR
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- 2021
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3. Additional file 1 of Changes of DNA methylation are associated with changes in lung function during adolescence
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Sunny, Shadia Khan, Hongmei Zhang, Rezwan, Faisal I., Relton, Caroline L., A. John Henderson, Merid, Simon Kebede, Melén, Erik, Hallberg, Jenny, S. Hasan Arshad, Ewart, Susan, and Holloway, John W.
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sense organs ,respiratory system ,skin and connective tissue diseases ,circulatory and respiratory physiology ,respiratory tract diseases - Abstract
Additional file 1 Table S1. List of CpGs (k = 42) at which changes of DNA-M were significantly associated with changes of FEV1/FVC in females in IOW cohort and examined among the females in ALSPAC and BAMSE cohorts.
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- 2020
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4. Supplemental_Tables_xyz29536d7d85c79 – Supplemental material for Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma
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Aniruddha Rathod, Jiasong Duan, Hongmei Zhang, Holloway, John W, Ewart, Susan, S Hasan Arshad, and Karmaus, Wilfried
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Cell Biology - Abstract
Supplemental material, Supplemental_Tables_xyz29536d7d85c79 for Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma by Aniruddha Rathod, Jiasong Duan, Hongmei Zhang, John W Holloway, Susan Ewart, S Hasan Arshad and Wilfried Karmaus in Epigenetics Insights
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- 2020
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5. Additional file 3 of Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
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Merid, Simon, Novoloaca, Alexei, Sharp, Gemma, Küpers, Leanne, Kho, Alvin, Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne, Kazmi, Nabila, Salas, Lucas, Rezwan, Faisal, Hongmei Zhang, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl, Melton, Phillip, Lawlor, Debbie, Pershagen, Göran, Breton, Carrie, Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim, Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen, Mariona Bustamante, Ewart, Susan, Karmaus, Wilfried, Shanshan Zhao, Page, Christian, Herceg, Zdenko, Marjo-Riitta Jarvelin, Lahti, Jari, Baccarelli, Andrea, Anderson, Denise, Priyadarshini Kachroo, Relton, Caroline, Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent, Sørensen, Thorkild, Vrijheid, Martine, S. Arshad, Holloway, John, Håberg, Siri, Magnus, Per, Dwyer, Terence, Binder, Elisabeth, DeMeo, Dawn, Vonk, Judith, Newnham, John, Kelan Tantisira, Kull, Inger, Wiemels, Joseph, Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica, Räikkönen, Katri, Oken, Emily, Rae-Chi Huang, Weiss, Scott, Antó, Josep, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah, Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Marie-France Hivert, Felix, Janine, Koppelman, Gerard, London, Stephanie, and Melén, Erik
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Figure S1. Forest plot for the top 10 Bonferroni-significant CpGs from the meta-analysis on the association between continuous GA and offspring DNA methylation at birth adjusted for estimated cell proportions. Figure S2. Sensitivity analysis: Correlation of the point estimates for the no complications model main association of DNA methylation with gestational age (y-axis representing 3648 participants from 17 cohorts) with point estimates for a meta-analysis after excluding three cohorts (MoBa1, MoBa2 and ALSPAC) that were included in a previous publication1,2 (x-axis representing 2190 participants from 14 cohorts). Figure S3. Correlations between methylation and gene expression levels for selected four pairs. First, we created residuals for mRNA expression and residuals for DNA methylation and used linear regression models to evaluate correlations between expression residuals and methylation residuals. These residual models were adjusted for covariates, estimated white blood cell proportions, and technical variation. Figure S4. Sensitivity analysis: Correlation of the point estimates for the no complications model main association of DNA methylation with gestational age (y-axis representing 3648 participants from 17 cohorts) with point estimates for a meta-analysis after excluding Non-European three cohorts (CBC, CHS and CHAMACOS) (x-axis representing 3290 participants from 14 cohorts).
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- 2020
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6. Additional file 2 of Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
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Merid, Simon, Novoloaca, Alexei, Sharp, Gemma, Küpers, Leanne, Kho, Alvin, Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne, Kazmi, Nabila, Salas, Lucas, Rezwan, Faisal, Hongmei Zhang, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl, Melton, Phillip, Lawlor, Debbie, Pershagen, Göran, Breton, Carrie, Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim, Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen, Mariona Bustamante, Ewart, Susan, Karmaus, Wilfried, Shanshan Zhao, Page, Christian, Herceg, Zdenko, Marjo-Riitta Jarvelin, Lahti, Jari, Baccarelli, Andrea, Anderson, Denise, Priyadarshini Kachroo, Relton, Caroline, Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent, Sørensen, Thorkild, Vrijheid, Martine, S. Arshad, Holloway, John, Håberg, Siri, Magnus, Per, Dwyer, Terence, Binder, Elisabeth, DeMeo, Dawn, Vonk, Judith, Newnham, John, Kelan Tantisira, Kull, Inger, Wiemels, Joseph, Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica, Räikkönen, Katri, Oken, Emily, Rae-Chi Huang, Weiss, Scott, Antó, Josep, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah, Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Marie-France Hivert, Felix, Janine, Koppelman, Gerard, London, Stephanie, and Melén, Erik
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Supplementary information.
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- 2020
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7. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
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Küpers, Leanne K, Monnereau, Claire, Sharp, Gemma C, Yousefi, Paul, Salas, Lucas A, Ghantous, Akram, Page, Christian M, Reese, Sarah E, Wilcox, Allen J, Czamara, Darina, Starling, Anne P, Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie V, Allard, Catherine, Just, Allan C, Bakulski, Kelly M, Holloway, John W, Everson, Todd M, Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A, Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine AS, Richardson, Tom G, Magnus, Maria C, Nohr, Ellen A, Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L, Solomon, Olivia, Heimovaara, Joosje H, Jima, Dereje D, Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O, Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R, Gehring, Ulrike, Marsit, Carmen J, Beilin, Lawrence J, Vonk, Judith M, Jarvelin, Marjo-Riitta, Bergström, Anna, Örtqvist, Anne K, Ewart, Susan, Villa, Pia M, Moore, Sophie E, Willemsen, Gonneke, Standaert, Arnout RL, Håberg, Siri E, Sørensen, Thorkild IA, Taylor, Jack A, Räikkönen, Katri, Yang, Ivana V, Kechris, Katerina, Nawrot, Tim S, Silver, Matt J, Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A, Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L, Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A, Croen, Lisa A, Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hämäläinen, Esa, Routledge, Michael N, Boomsma, Dorret I, Feinberg, Andrew P, Newschaffer, Craig J, Govarts, Eva, Moisse, Matthieu, Fallin, M Daniele, Melén, Erik, and Prentice, Andrew M
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Adult ,Male ,Adolescent ,Reproductive health and childbirth ,Body Mass Index ,Fetal Development ,Fetus ,Folic Acid ,Genetic ,Pregnancy ,Infant Mortality ,Genetics ,2.1 Biological and endogenous factors ,Humans ,Birth Weight ,Aetiology ,Child ,Pediatric ,Genome ,Human Genome ,Smoking ,Infant ,DNA ,DNA Methylation ,Newborn ,Good Health and Well Being ,Prenatal Exposure Delayed Effects ,CpG Islands ,Female ,Epigenesis ,Human ,Genome-Wide Association Study - Abstract
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni
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- 2019
8. Additional file 1: of Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children
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Sherwood, William, Bion, Victoria, Lockett, Gabrielle, Ziyab, Ali, NelĂS Soto-RamĂRez, Mukherjee, Nandini, Kurukulaaratchy, Ramesh, Ewart, Susan, Hongmei Zhang, S. Arshad, Karmaus, Wilfried, Holloway, John, and Rezwan, Faisal
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animal structures ,education ,embryonic structures ,human activities ,hormones, hormone substitutes, and hormone antagonists - Abstract
Table S1. Annotation of LEP CpGs used in the analyses. Table S2. Stability of LEP CpGs (between 10 and 18 years).Table S3. Association between total breastfeeding duration and LEP DNAm (16 CpGs) at 18 years. Table S4. Association between exclusive breastfeeding duration and LEP DNAm (16 CpGs) at 18 years. Table S5. Association between total breastfeeding duration and LEP DNAm (23 CpGs) at 10 years. Table S6. Association between exclusive breastfeeding duration and LEP DNAm (23 CpGs) at 10 years. Table S7. Association between BMI trajectories and LEP DNAm (at 10 years) at CpGs previously associated with total or exclusive breastfeeding duration (associated P-values have been shown). Figure S1. Comparisons of methylation level (beta) of significant common CpGs in matched 162 samples (10 and 8 years). (DOCX 3070 kb)
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- 2019
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9. MOESM3 of Epigenome-wide association study of asthma and wheeze characterizes loci within HK1
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Everson, Todd, Hongmei Zhang, Lockett, Gabrielle, Akhilesh Kaushal, Forthofer, Melinda, Ewart, Susan, Burrows, Kimberley, Relton, Caroline, Sharp, Gemma, A. Henderson, Veeresh Patil, Rezwan, Faisal, S. Arshad, Holloway, John, and Karmaus, Wilfried
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Additional file 3: This file includes supplemental figures (S1, S2)—Figure S1. Tracking of the misclassification rates (y-axis) across iterations (x-axis) of the recursive RF feature selection. Figure S2. Correlations (Spearman) between estimated cell-proportions in blood and DNAM M-values for the 10 CpGs that were identified as candidates for the replication study. Statistically significant correlations are designated at p-values
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- 2019
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10. MOESM1 of Epigenome-wide association study of asthma and wheeze characterizes loci within HK1
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Everson, Todd, Hongmei Zhang, Lockett, Gabrielle, Akhilesh Kaushal, Forthofer, Melinda, Ewart, Susan, Burrows, Kimberley, Relton, Caroline, Sharp, Gemma, A. Henderson, Veeresh Patil, Rezwan, Faisal, S. Arshad, Holloway, John, and Karmaus, Wilfried
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Additional file 1: Method S1. Cohort-Specific DNA-M preprocessing steps. Methods S2. SVA to account for technical variations in ALSPAC.
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- 2019
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11. Additional file 1: of Leptin receptor gene polymorphisms and sex modify the association between acetaminophen use and asthma among young adults: results from two observational studies
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Ziyab, Ali, Mukherjee, Nandini, Kurukulaaratchy, Ramesh, Hongmei Zhang, Ewart, Susan, Arshad, Hasan, and Karmaus, Wilfried
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hormones, hormone substitutes, and hormone antagonists - Abstract
Supplementary Material. Kuwait University Allergy (KUA) study – Study setting and population. Isle of Wight (IOW) birth cohort study – Study setting and population. LEP and LEPR genotyping – IOW study. Additional file: Table S1. Genotype and minor allele frequencies of leptin (LEP) and leptin receptor (LEPR) gene single nucleotide polymorphisms: results from the Isle of Wight study. Additional file:Table S2. Evaluating three-way statistical interactions on a multiplicative scale between sex, acetaminophen use and polymorphisms in leptin (LEP) and leptin receptor (LEPR) genes on the risk of current asthma: results from the Isle of Wight study. Additional file 1: Table S3. Associations between acetaminophen use and current asthma stratified by sex and genotypes of leptin receptor (LEPR) gene polymorphisms: results from the Isle of Wight study. Addtional file 1: Table S4. Associations between acetaminophen use and current asthma in the total population and stratified by sex: results of sensitivity analysis from the Isle of Wight and Kuwait University Allergy studies. Additional file 1: Figure S1. Estimates of linkage disequilibrium (LD) between leptin (LEP) gene single nucleotide polymorphisms. (A) LD estimates using D′ values and (B) LD estimates using r2 values: results from the Isle of Wight study. Additional file 1: Figure S2. Estimates of linkage disequilibrium (LD) between leptin receptor (LEPR) gene single nucleotide polymorphisms. (A) LD estimates using D′ values and (B) LD estimates using r2 values: results from the Isle of Wight study. (PDF 147 kb)
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- 2018
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12. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
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Joubert, Bonnie R, Felix, Janine F, Yousefi, Paul, Bakulski, Kelly M, Just, Allan C, Breton, Carrie, Reese, Sarah E, Markunas, Christina A, Richmond, Rebecca C, Xu, Cheng-Jian, Küpers, Leanne K, Oh, Sam S, Hoyo, Cathrine, Gruzieva, Olena, Söderhäll, Cilla, Salas, Lucas A, Baïz, Nour, Zhang, Hongmei, Lepeule, Johanna, Ruiz, Carlos, Ligthart, Symen, Wang, Tianyuan, Taylor, Jack A, Duijts, Liesbeth, Sharp, Gemma C, Jankipersadsing, Soesma A, Nilsen, Roy M, Vaez, Ahmad, Fallin, M Daniele, Hu, Donglei, Litonjua, Augusto A, Fuemmeler, Bernard F, Huen, Karen, Kere, Juha, Kull, Inger, Munthe-Kaas, Monica Cheng, Gehring, Ulrike, Bustamante, Mariona, Saurel-Coubizolles, Marie José, Quraishi, Bilal M, Ren, Jie, Tost, Jörg, Gonzalez, Juan R, Peters, Marjolein J, Håberg, Siri E, Xu, Zongli, van Meurs, Joyce B, Gaunt, Tom R, Kerkhof, Marjan, Corpeleijn, Eva, Feinberg, Andrew P, Eng, Celeste, Baccarelli, Andrea A, Benjamin Neelon, Sara E, Bradman, Asa, Merid, Simon Kebede, Bergström, Anna, Herceg, Zdenko, Hernandez-Vargas, Hector, Brunekreef, Bert, Pinart, Mariona, Heude, Barbara, Ewart, Susan, Yao, Jin, Lemonnier, Nathanaël, Franco, Oscar H, Wu, Michael C, Hofman, Albert, McArdle, Wendy, Van der Vlies, Pieter, Falahi, Fahimeh, Gillman, Matthew W, Barcellos, Lisa F, Kumar, Ashish, Wickman, Magnus, Guerra, Stefano, Charles, Marie-Aline, Holloway, John, Auffray, Charles, Tiemeier, Henning W, Smith, George Davey, Postma, Dirkje, Hivert, Marie-France, Eskenazi, Brenda, Vrijheid, Martine, Arshad, Hasan, Antó, Josep M, Dehghan, Abbas, Karmaus, Wilfried, Annesi-Maesano, Isabella, Sunyer, Jordi, Ghantous, Akram, Pershagen, Göran, Holland, Nina, Murphy, Susan K, DeMeo, Dawn L, Burchard, Esteban G, Ladd-Acosta, Christine, Snieder, Harold, and Nystad, Wenche
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Cleft Lip ,Reproductive health and childbirth ,Medical and Health Sciences ,White People ,Genetic ,Pregnancy ,Tobacco ,Genetics ,Humans ,2.2 Factors relating to the physical environment ,2.1 Biological and endogenous factors ,Aetiology ,Child ,Preschool ,Genetic Association Studies ,Pediatric ,Genetics & Heredity ,Tobacco Smoke and Health ,Prevention ,Smoking ,Human Genome ,Chromosome Mapping ,Infant ,DNA Methylation ,Biological Sciences ,Newborn ,Asthma ,Cleft Palate ,Good Health and Well Being ,Respiratory ,Female ,Epigenesis - Abstract
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2× 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
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- 2016
13. Maternal smoking during gestation, differential DNA methylation, and changes in lung function at age 18 years
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Holloway John W, Arshad Hasan S, Ewart Susan, Zhang Hongmei, and Karmaus Wilfried
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business.industry ,Maternal smoking ,Respiratory disease ,Physiology ,medicine.disease ,DNA methylation ,General Earth and Planetary Sciences ,Medicine ,Gestation ,business ,Birth cohort ,Adult health ,Lung function ,General Environmental Science ,Cohort study - Abstract
Background: DNA methylation (DNA-M) is considered to constitute an archive of past exposures, which may link gestational exposures with child and adult health outcomes. Aims: In a birth cohort foll...
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- 2013
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14. Additional file 2 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
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Vehmeijer, Florianne O. L., Küpers, Leanne K., Sharp, Gemma C., Salas, Lucas A., Lent, Samantha, Dereje D. Jima, Tindula, Gwen, Reese, Sarah, Cancan Qi, Gruzieva, Olena, Page, Christian, Rezwan, Faisal I., Melton, Philip E., Nohr, Ellen, Geòrgia Escaramís, Rzehak, Peter, Heiskala, Anni, Gong, Tong, Tuominen, Samuli T., Gao, Lu, Ross, Jason P., Starling, Anne P., Holloway, John W., Yousefi, Paul, Aasvang, Gunn Marit, Beilin, Lawrence J., Bergström, Anna, Binder, Elisabeth, Chatzi, Leda, Corpeleijn, Eva, Czamara, Darina, Eskenazi, Brenda, Ewart, Susan, Ferre, Natalia, Grote, Veit, Gruszfeld, Dariusz, Håberg, Siri E., Hoyo, Cathrine, Huen, Karen, Karlsson, Robert, Kull, Inger, Langhendries, Jean-Paul, Lepeule, Johanna, Magnus, Maria C., Maguire, Rachel L., Molloy, Peter L., Monnereau, Claire, Mori, Trevor A., Oken, Emily, Räikkönen, Katri, Rifas-Shiman, Sheryl, Ruiz-Arenas, Carlos, Sebert, Sylvain, Ullemar, Vilhelmina, Verduci, Elvira, Vonk, Judith M., Xu, Cheng-Jian, Yang, Ivana V., Hongmei Zhang, Weiming Zhang, Karmaus, Wilfried, Dabelea, Dana, Muhlhausler, Beverly S., Breton, Carrie V., Lahti, Jari, Almqvist, Catarina, Marjo-Riitta Jarvelin, Koletzko, Berthold, Vrijheid, Martine, Sørensen, Thorkild I. A., Rae-Chi Huang, Arshad, Syed Hasan, Nystad, Wenche, Melén, Erik, Koppelman, Gerard H., London, Stephanie J., Holland, Nina, Mariona Bustamante, Murphy, Susan K., Marie-France Hivert, Baccarelli, Andrea, Relton, Caroline L., Snieder, Harold, Jaddoe, Vincent W. V., and Felix, Janine F.
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2. Zero hunger - Abstract
Additional file 2: Supplementary Methods. Study-specific funding, acknowledgements and methods in alphabetical order, including references.
15. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
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Sikdar, Sinjini, Joehanes, Roby, Joubert, Bonnie R, Xu, Cheng-Jian, Vives-Usano, Marta, Rezwan, Faisal I, Felix, Janine F, Ward, James M, Guan, Weihua, Richmond, Rebecca C, Brody, Jennifer A, Küpers, Leanne K, Baïz, Nour, Håberg, Siri E, Smith, Jennifer A, Reese, Sarah E, Aslibekyan, Stella, Hoyo, Cathrine, Dhingra, Radhika, Markunas, Christina A, Xu, Tao, Reynolds, Lindsay M, Just, Allan C, Mandaviya, Pooja R, Ghantous, Akram, Bennett, Brian D, Wang, Tianyuan, Consortium, The Bios, Bakulski, Kelly M, Melen, Erik, Zhao, Shanshan, Jin, Jianping, Herceg, Zdenko, Meurs, Joyce Van, Taylor, Jack A, Baccarelli, Andrea A, Murphy, Susan K, Liu, Yongmei, Munthe-Kaas, Monica Cheng, Deary, Ian J, Nystad, Wenche, Waldenberger, Melanie, Annesi-Maesano, Isabella, Conneely, Karen, Jaddoe, Vincent Wv, Arnett, Donna, Snieder, Harold, Kardia, Sharon Lr, Relton, Caroline L, Ong, Ken K, Ewart, Susan, Moreno-Macias, Hortensia, Romieu, Isabelle, Sotoodehnia, Nona, Fornage, Myriam, Motsinger-Reif, Alison, Koppelman, Gerard H, Bustamante, Mariona, Levy, Daniel, and London, Stephanie J
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Adult ,Epigenomics ,epigenetics ,Infant, Newborn ,cigarette smoking ,DNA Methylation ,infant ,3. Good health ,Epigenesis, Genetic ,Cohort Studies ,Maternal Exposure ,Pregnancy ,Prenatal Exposure Delayed Effects ,Tobacco Smoking ,Humans ,CpG Islands ,Female ,methylation - Abstract
Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
16. Additional file 5 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
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Vehmeijer, Florianne O. L., Küpers, Leanne K., Sharp, Gemma C., Salas, Lucas A., Lent, Samantha, Dereje D. Jima, Tindula, Gwen, Reese, Sarah, Cancan Qi, Gruzieva, Olena, Page, Christian, Rezwan, Faisal I., Melton, Philip E., Nohr, Ellen, Geòrgia Escaramís, Rzehak, Peter, Heiskala, Anni, Gong, Tong, Tuominen, Samuli T., Gao, Lu, Ross, Jason P., Starling, Anne P., Holloway, John W., Yousefi, Paul, Aasvang, Gunn Marit, Beilin, Lawrence J., Bergström, Anna, Binder, Elisabeth, Chatzi, Leda, Corpeleijn, Eva, Czamara, Darina, Eskenazi, Brenda, Ewart, Susan, Ferre, Natalia, Grote, Veit, Gruszfeld, Dariusz, Håberg, Siri E., Hoyo, Cathrine, Huen, Karen, Karlsson, Robert, Kull, Inger, Langhendries, Jean-Paul, Lepeule, Johanna, Magnus, Maria C., Maguire, Rachel L., Molloy, Peter L., Monnereau, Claire, Mori, Trevor A., Oken, Emily, Räikkönen, Katri, Rifas-Shiman, Sheryl, Ruiz-Arenas, Carlos, Sebert, Sylvain, Ullemar, Vilhelmina, Verduci, Elvira, Vonk, Judith M., Xu, Cheng-Jian, Yang, Ivana V., Hongmei Zhang, Weiming Zhang, Karmaus, Wilfried, Dabelea, Dana, Muhlhausler, Beverly S., Breton, Carrie V., Lahti, Jari, Almqvist, Catarina, Marjo-Riitta Jarvelin, Koletzko, Berthold, Vrijheid, Martine, Sørensen, Thorkild I. A., Rae-Chi Huang, Arshad, Syed Hasan, Nystad, Wenche, Melén, Erik, Koppelman, Gerard H., London, Stephanie J., Holland, Nina, Mariona Bustamante, Murphy, Susan K., Marie-France Hivert, Baccarelli, Andrea, Relton, Caroline L., Snieder, Harold, Jaddoe, Vincent W. V., and Felix, Janine F.
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2. Zero hunger - Abstract
Additional file 5: Supplementary Information. Figures S1 – 6.
17. Additional file 5 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
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Vehmeijer, Florianne O. L., Küpers, Leanne K., Sharp, Gemma C., Salas, Lucas A., Lent, Samantha, Dereje D. Jima, Tindula, Gwen, Reese, Sarah, Cancan Qi, Gruzieva, Olena, Page, Christian, Rezwan, Faisal I., Melton, Philip E., Nohr, Ellen, Geòrgia Escaramís, Rzehak, Peter, Heiskala, Anni, Gong, Tong, Tuominen, Samuli T., Gao, Lu, Ross, Jason P., Starling, Anne P., Holloway, John W., Yousefi, Paul, Aasvang, Gunn Marit, Beilin, Lawrence J., Bergström, Anna, Binder, Elisabeth, Chatzi, Leda, Corpeleijn, Eva, Czamara, Darina, Eskenazi, Brenda, Ewart, Susan, Ferre, Natalia, Grote, Veit, Gruszfeld, Dariusz, Håberg, Siri E., Hoyo, Cathrine, Huen, Karen, Karlsson, Robert, Kull, Inger, Langhendries, Jean-Paul, Lepeule, Johanna, Magnus, Maria C., Maguire, Rachel L., Molloy, Peter L., Monnereau, Claire, Mori, Trevor A., Oken, Emily, Räikkönen, Katri, Rifas-Shiman, Sheryl, Ruiz-Arenas, Carlos, Sebert, Sylvain, Ullemar, Vilhelmina, Verduci, Elvira, Vonk, Judith M., Xu, Cheng-Jian, Yang, Ivana V., Hongmei Zhang, Weiming Zhang, Karmaus, Wilfried, Dabelea, Dana, Muhlhausler, Beverly S., Breton, Carrie V., Lahti, Jari, Almqvist, Catarina, Marjo-Riitta Jarvelin, Koletzko, Berthold, Vrijheid, Martine, Sørensen, Thorkild I. A., Rae-Chi Huang, Arshad, Syed Hasan, Nystad, Wenche, Melén, Erik, Koppelman, Gerard H., London, Stephanie J., Holland, Nina, Mariona Bustamante, Murphy, Susan K., Marie-France Hivert, Baccarelli, Andrea, Relton, Caroline L., Snieder, Harold, Jaddoe, Vincent W. V., and Felix, Janine F.
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2. Zero hunger - Abstract
Additional file 5: Supplementary Information. Figures S1 – 6.
18. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
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Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C., Küpers, Leanne K., Kho, Alvin T., Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O., Kazmi, Nabila, Salas, Lucas A., Rezwan, Faisal I., Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L., Melton, Phillip E., Lawlor, Debbie A., Pershagen, Göran, Breton, Carrie V., Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S., Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L., Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M., Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A., Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L., Bergström, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W., Sørensen, Thorkild I. A., Vrijheid, Martine, Arshad, S. Hasan, Holloway, John W., Håberg, Siri E., Magnus, Per, Dwyer, Terence, Binder, Elisabeth B., DeMeo, Dawn L., Vonk, Judith M., Newnham, John, Tantisira, Kelan G., Kull, Inger, Wiemels, Joseph L., Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C., Räikkönen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T., Antó, Josep Maria, Bousquet, Jean, Kumar, Ashish, Söderhäll, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E., Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F., Koppelman, Gerard H., London, Stephanie J., and Melén, Erik
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3. Good health
19. Additional file 2 of DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
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Vehmeijer, Florianne O. L., Küpers, Leanne K., Sharp, Gemma C., Salas, Lucas A., Lent, Samantha, Dereje D. Jima, Tindula, Gwen, Reese, Sarah, Cancan Qi, Gruzieva, Olena, Page, Christian, Rezwan, Faisal I., Melton, Philip E., Nohr, Ellen, Geòrgia Escaramís, Rzehak, Peter, Heiskala, Anni, Gong, Tong, Tuominen, Samuli T., Gao, Lu, Ross, Jason P., Starling, Anne P., Holloway, John W., Yousefi, Paul, Aasvang, Gunn Marit, Beilin, Lawrence J., Bergström, Anna, Binder, Elisabeth, Chatzi, Leda, Corpeleijn, Eva, Czamara, Darina, Eskenazi, Brenda, Ewart, Susan, Ferre, Natalia, Grote, Veit, Gruszfeld, Dariusz, Håberg, Siri E., Hoyo, Cathrine, Huen, Karen, Karlsson, Robert, Kull, Inger, Langhendries, Jean-Paul, Lepeule, Johanna, Magnus, Maria C., Maguire, Rachel L., Molloy, Peter L., Monnereau, Claire, Mori, Trevor A., Oken, Emily, Räikkönen, Katri, Rifas-Shiman, Sheryl, Ruiz-Arenas, Carlos, Sebert, Sylvain, Ullemar, Vilhelmina, Verduci, Elvira, Vonk, Judith M., Xu, Cheng-Jian, Yang, Ivana V., Hongmei Zhang, Weiming Zhang, Karmaus, Wilfried, Dabelea, Dana, Muhlhausler, Beverly S., Breton, Carrie V., Lahti, Jari, Almqvist, Catarina, Marjo-Riitta Jarvelin, Koletzko, Berthold, Vrijheid, Martine, Sørensen, Thorkild I. A., Rae-Chi Huang, Arshad, Syed Hasan, Nystad, Wenche, Melén, Erik, Koppelman, Gerard H., London, Stephanie J., Holland, Nina, Mariona Bustamante, Murphy, Susan K., Marie-France Hivert, Baccarelli, Andrea, Relton, Caroline L., Snieder, Harold, Jaddoe, Vincent W. V., and Felix, Janine F.
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2. Zero hunger - Abstract
Additional file 2: Supplementary Methods. Study-specific funding, acknowledgements and methods in alphabetical order, including references.
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