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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
- Source :
- Nature communications, vol 10, iss 1
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni
- Subjects :
- Adult
Male
Adolescent
Reproductive health and childbirth
Body Mass Index
Fetal Development
Fetus
Folic Acid
Genetic
Pregnancy
Infant Mortality
Genetics
2.1 Biological and endogenous factors
Humans
Birth Weight
Aetiology
Child
Pediatric
Genome
Human Genome
Smoking
Infant
DNA
DNA Methylation
Newborn
Good Health and Well Being
Prenatal Exposure Delayed Effects
CpG Islands
Female
Epigenesis
Human
Genome-Wide Association Study
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature communications, vol 10, iss 1
- Accession number :
- edsair.dedup.wf.001..be237b951bee3fe3d48ca8920e953cc5