1. Potent benzimidazolone based human beta(3)-adrenergic receptor agonists
- Author
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Don Richard Finley, Mark A. Winter, Daniel Jon Sall, Mark L. Heiman, Marlene L. Cohen, Christopher John Rito, Tania Miles, Anthony J. Shuker, William E. Bloomquist, Anthony G. Borel, Thomas W. Stephens, Michael Gregory Bell, Cynthia Darshini Jesudason, Aidas Kriauciunas, Donald P. Matthews, David Andrew Neel, and Frank C. Tinsley
- Subjects
Beta-3 adrenergic receptor ,Agonist ,medicine.medical_specialty ,medicine.drug_class ,Clinical Biochemistry ,Pharmaceutical Science ,Carboxamide ,Biochemistry ,Chemical synthesis ,Beta-1 adrenergic receptor ,Internal medicine ,Drug Discovery ,medicine ,Moiety ,Humans ,cardiovascular diseases ,Beta (finance) ,Molecular Biology ,Chemistry ,Organic Chemistry ,Adrenergic beta-Agonists ,In vitro ,Endocrinology ,cardiovascular system ,Molecular Medicine ,Benzimidazoles ,Adrenergic beta-3 Receptor Antagonists - Abstract
The synthesis and biological evaluation of a series of benzimidazolone beta(3) adrenergic receptor agonists are described. A trend toward the reduction of rat atrial tachycardia upon increasing steric bulk at the 3-position of the benzimidazolone moiety was observed.
- Published
- 2006