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El manual de procedimientos administrativos de las instituciones educativas del Ecuador, se enfoca en conducir a los miembros de todas las instituciones a reflexionar sobre sus distintas experiencias, a fin de fomentar un proceso de administración y planificación escolar cónsono con sus realidades. Se profundizará de forma reflexiva acerca de los aspectos que forman parte del hecho educativo y que dan lugar a la dinamización de la enseñanza y el aprendizaje; es decir, de los objetivos, los contenidos, los procesos metodológicos, los medios y recursos materiales y las estrategias de evaluación. Luego de analizados, se procederán a realizar actividades prácticas que permitirán al lector contextualizar lo teórico en la praxis. Se tratarán las orientaciones básicas para la planificación didáctica y la buena administración escolar, a objeto de sentar las bases de un proceso educativo eficiente en los diferentes niveles educativos y modalidades del sistema, culminando con el nivel parvulario, tema medular de este texto.

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies., Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb293

The multi-commodity network flow problem (MCNF) consists in routing a set of commodities through a capacitated network at minimum cost and is relevant for routing containers in liner shipping networks. As commodity transit times are often a critical factor, the literature has introduced hard limits on commodity transit times. In practical contexts, however, these hard limits may fail to provide sufficient flexibility since routes with even tiny delays would be discarded. Motivated by a major liner shipping operator, we study an MCNF generalization where transit time restrictions are modeled as soft constraints, in which delays are discouraged using penalty functions of transit time. Similarly, early commodity arrivals can receive a discount in cost. We derive properties that distinguish this model from other MCNF variants and adapt a column generation procedure to efficiently solve it. Extensive numerical experiments conducted on realistic liner shipping instances reveal that the explicit consideration of penalty functions can lead to significant cost reductions compared to hard transit time deadlines. Moreover, the penalties can be used to steer the flow towards slower or faster configurations, resulting in a potential increase in operational costs, which generates a trade-off that we quantify under varying penalty functions.

The high-resolution mid-infrared spectrometer (HIRMES) is a high resolving power (R ~ 100,000) instrument operating in the 25–122 μm spectral range and will fly on board the Stratospheric Observatory for Far-Infrared Astronomy in 2019. Central to HIRMES are its two transition edge sensor (TES) bolometric cameras, an 8 × 16 detector high-resolution array and a 64 × 16 detector low-resolution array. Both types of detectors consist of Mo/Au TES fabricated on leg-isolated Si membranes. Whereas the high-resolution detectors, with a noise equivalent power (NEP) ~ 1.5 × 10−18 W/rt (Hz), are fabricated on 0.45 μm Si substrates, the low-resolution detectors, with NEP ~ 1.0 × 10−17 W/rt (Hz), are fabricated on 1.40 μm Si. Here, we discuss the similarities and differences in the fabrication methodologies used to realize the two types of detectors.

This paper introduces the transit time constrained fixed charge multi-commodity network design problem. Transit times are origin-to-destination time limits for the commodities, which appear for example in transport systems with perishable goods. We discuss how to model the problem and present three different formulations of it. The first formulation is an exponential size path formulation, which we solve with a branch-and-price algorithm. Several speed up techniques from the literature on fixed charge multi-commodity network design problems are implemented, such as lifted cover inequalities and the recently proposed deep dual-optimal inequalities. In an extensive set of computational experiments, we show that these inequalities significantly improve the performance of the algorithm. The other two formulations are of polynomial size: one uses path indices and the other uses time indices. While the branch-and-price algorithm outperforms solving the compact formulations with a general-purpose mixed-integer programming solver, the study of compact models helps better understand the problem, and we can use them as benchmarks. A detailed sensitivity analysis of the branch-and-price algorithm shows that longer transit times and an increased ratio of fixed charge to flow cost increase the difficulty of solving the problem whereas the arc capacity has less impact. We further discuss in-depth implementational details.

We consider a strategic infrastructure and tanker fleet sizing problem in the liquefied natural gas business. The goal is to minimize long-term on-shore infrastructure and tanker investment cost combined with interrelated expected cost for operating the tanker fleet. A non-linear arc-based model and an exact solution method based on a set-partitioning formulation are developed. The latter approach allows very fast solution times. Computational results for a case study with a liner shipping company are presented, including an extensive sensitivity analysis to account for limited predictability of key parameter values, to analyze the solutions’ robustness and to derive basic decision rules.

For more than a decade, the United States has performed environmental monitoring by collecting and analyzing air samples for a handful of biological threat agents (BTAs) in order to detect a possible biological attack. This effort has faced numerous technical challenges including timeliness, sampling efficiency, sensitivity, specificity, and robustness. The cost of city-wide environmental monitoring using conventional technology has also been a challenge. A large group of scientists with expertise in bioterrorism defense met to assess the objectives and current efficacy of environmental monitoring and to identify operational and technological changes that could enhance its efficacy and cost-effectiveness, thus enhancing its value. The highest priority operational change that was identified was to abandon the current concept of city-wide environmental monitoring because the operational costs were too high and its value was compromised by low detection sensitivity and other environmental factors. Instead, it was suggested that the focus should primarily be on indoor monitoring and secondarily on special-event monitoring because objectives are tractable and these operational settings are aligned with likelihood and risk assessments. The highest priority technological change identified was the development of a reagent-less, real-time sensor that can identify a potential airborne release and trigger secondary tests of greater sensitivity and specificity for occasional samples of interest. This technological change could be transformative with the potential to greatly reduce operational costs and thereby create the opportunity to expand the scope and effectiveness of environmental monitoring.

On March 10 to March 12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland, to assess progress and new opportunities for research in tuberous sclerosis complex with the goal of updating the 2003 Research Plan for Tuberous Sclerosis (http://www.ninds.nih.gov/about_ninds/plans/tscler_research_plan.htm). In addition to the National Institute of Neurological Disorders and Stroke and Tuberous Sclerosis Alliance, participants in the strategic planning effort and workshop included representatives from six other Institutes of the National Institutes of Health, the Department of Defense Tuberous Sclerosis Complex Research Program, and a broad cross-section of basic scientists and clinicians with expertise in tuberous sclerosis complex along with representatives from the pharmaceutical industry. Here we summarize the outcomes from the extensive premeeting deliberations and final workshop recommendations, including (1) progress in the field since publication of the initial 2003 research plan for tuberous sclerosis complex, (2) the key gaps, needs, and challenges that hinder progress in tuberous sclerosis complex research, and (3) a new set of research priorities along with specific recommendations for addressing the major challenges in each priority area. The new research plan is organized around both short-term and long-term goals with the expectation that progress toward specific objectives can be achieved within a five to ten year time frame.

Pediatric formulation development requires an understanding of the physico-chemical stability and the taste of the pharmaceutical drug product. Two model active pharmaceutical ingredients (compound X and compound Y) were used to develop a powder for reconstitution to a suspension and a solution dosage form after dilution with purified water. X-ray powder diffraction was used to monitor the physical stability of compound X in the suspension and high pressure liquid chromatography was used to monitor the chemical stability of compound Y in the solution. The most stable suspension (formulation T) and solution (formulation Z) were used to assess the change in taste-perception by different flavors using the Astree™ electronic tongue. The suspension was determined to be stable for 43 days and 21 days respectively at 5 °C and 25 °C/60% RH. Compound Y solution was chemically stable for up to 30 days at 25 °C/60% RH. The taste of the suspension was improved by Lemon and Cherry flavors. The taste of the solution was made better by Vanilla, Cherry, and Strawberry flavors. The significance of these results is that the e-Tongue can be used in the early stages of formulation development to eliminate flavors that do little to improve the palatability of a formulation.

Introduction This article describes an observational study of caring behaviors in the emergency departments of 4 Ascension Health hospitals and the impact of these behaviors on patient loyalty to the associated hospital. These hospitals were diverse in size and geography, representing 3 large urban community hospitals in metropolitan areas and 1 in a midsized city. Methods Research assistants from Purdue University (West Lafayette, IN) conducted observations at the first study site and validated survey instruments. The Purdue research assistants trained contracted observers at the subsequent study sites. The research assistants conducted observational studies of caregivers in the emergency departments at 4 study sites using convenience sampling of patients. Caring behaviors were rated from 0 (did not occur) to 5 (high intensity). The observation included additional information, for example, caregiver roles, timing, and type of visit. Observed and unobserved patients completed exit surveys that recorded patient responses to the likelihood-to-recommend (loyalty) questions, patient perceptions of care, and demographic information. Results Common themes across all study sites emerged, including (1) the area that patients considered most important to an ED experience (prompt attention to their needs upon arrival to the emergency department); (2) the area that patients rated as least positive in their actual ED experience (prompt attention to their needs upon arrival to the emergency department); (3) caring behaviors that significantly affected patient loyalty (eg, making sure that the patient is aware of care-related details, working with a caring touch, and making the treatment procedure clearly understood by the patient); and (4) the impact of wait time to see a caregiver on patient loyalty. A number of correlations between caring behaviors and patient loyalty were statistically significant (P Discussion The study results raised considerations for ED caregivers, particularly with regard to those caring behaviors that are most closely linked to patient loyalty but that occurred least frequently. The study showed through factor analysis that some caring behaviors tended to occur together, suggesting an underlying, unifying dimension to that factor.

Isobenzofurans (IBF)s have seen widespread use in the synthesis of both natural products and polycyclic aromatic hydrocarbons. There are few examples that have two IBF entities linked in a fused aromatic ring system. Here we present the synthesis and characterization of a bis(IBF), 2,7-di(tert-butyl)pyreno[4,5-c:9,10-c']difuran. Reaction with bis(maleimide) dienophiles gives pyrenophanes. The solid-state structures of the bis(IBF) and two cyclophanes are discussed.

A thin film of MgB 2 , grown on a SiN–Si substrate, with a superconducting transition temperature, T c , near 39 K has been irradiated with γ-rays from a 60 Co source. The total dose was 100 Krads (Si). Its pre- and post-irradiation noise has been measured and noise spectral density plots made. No change in d R /d T , pre- and post-irradiation was measured. At the mid-point of the transition, T = 38.24 K, a noise spectral density S V = 0.34 nV Hz −1/2 was measured at 10 Hz. The temperature noise, K n , of the MgB 2 film at different frequencies is compared to that of high temperature superconducting (HTS) thin films (YBaCuO and GdBaCuO with T c ∼ 90 K) used currently in HTS transition-edge bolometers. Even with the observed post-irradiation small increase in noise, its lower T c and K n values predict that high performance far IR bolometers can be developed using MgB 2 as a thermistor.

The external quantum efficiency in the spectral wavelength range 5–500 nm of a large active area Pt/n-type GaN Schottky photodiode that exhibits low reverse bias leakage current, is reported. The Schottky photodiodes were fabricated from n−/n+ epitaxial layers grown by low pressure metalorganic vapour phase epitaxy on single crystal c-plane sapphire. The current–voltage ( I – V ) characteristics of several 0.25 cm2 devices are presented together with the capacitance–voltage ( C – V ) characteristics of one of these devices. A leakage current as low as 14 pA at 0.5 V reverse bias is reported, for a 0.25 cm2 diode. The ultraviolet quantum efficiency measurements show that the diodes can be used as radiation hard detectors for the 5–365 nm spectral range without the use of visible blocking filters. A peak responsivity of 77.5 mA/W at 320 nm is reported for one of the fabricated devices, corresponding to a spectral detectivity, D * = 1.5 × 1 0 14 cm Hz 1 / 2 W - 1 . The average detectivity between 250 and 350 nm, for the same device, is reported to be D ¯ * = 1.3 × 1 0 14 cm Hz 1 / 2 W - 1 . The spatial responsivity uniformity variation was established, using H2 Lyman-α radiation, to be ±3% across the surface of a typical 0.25 cm2 diode.

Pt/4H-SiC Schottky photodiodes have been fabricated with the device areas up to 1 cm/sup 2/. The I-V characteristics and photoresponse spectra have been measured and analyzed. For a 5 mm/spl times/5 mm area device leakage current lower than 10/sup -15/ A at zero bias and 1.2/spl times/10/sup -14/ A at -1 V have been established. The quantum efficiency is over 30% from 240 to 320 nm. The specific detectivity, D/sup */, has been calculated from the directly measured leakage current and quantum efficiency are shown to be higher than 10/sup 15/ cmHz/sup 1/2//W from 210 to 350 nm with a peak D/sup */ of 3.6/spl times/10/sup 15/ cmHz/sup 1/2//W at 300 nm.

Recent evidence suggests that stem cell differentiation can be regulated by modulation of the cell’s biomechanics. The cytoskeletal structures and arrangements in stem cells undergoing differentiation are dramatically altered, and these alterations vary by lineage. The complexity of events associated with the transformation of these precursor cells leaves many questions unanswered about morphological, structural, proteomic, and functional changes in differentiating stem cells. A thorough understanding of stem cell behavior, both experimentally and computationally, would allow for the development of more effective approaches to the expansion of stem cells in vitro and for the regulation of their commitment to a specific phenotype.

Im Folgenden werden die NBD-Modelle mit realen Daten angewandt. Genauer werden das ursprungliche NBD-Modell (vgl. Ehrenberg 1959; Ehrenberg 1988) sowie die NBD- Erweiterungen Pareto-NBD (vgl. Schmittlein/Morrison/Colombo 1987; Schmittlein/Peterson 1994; Fader/Hardie 2005c) und BG-NBD (vgl. Fader/Hardie/Lee 2005, 2008) anhand hauptsachlich zweier Datensatze implementiert.

Vollstochastische Modelle basieren auf den Annahmen des stochastischen Prozesses. Sie beschranken sich auf das Identifizieren des „Wahrscheinlichkeitsgesetzes“, nach welchem beobachtbare Transaktionen sich nachempfinden lassen.

Nachdem die erweiterten NBD-Modelle in Kapitel 3 „Vollstochastische RFM- Prognosemodelle“ vorgestellt und in Kapitel 4 die „Implementierung der ausgewahlten NBD-Modelle“ erlautert wurde, werden in diesem Abschnitt die Ergebnisse der Modellim-plementierung vorgestellt.

All life forms depend ultimately upon sunlight to create the energy ‘currency’ required for the functions of living. Green plants can make that conversion directly but the rest of us would perish without access to foods derived, directly or indirectly, from plants. We also require their fibre which we use for clothing, building and other purposes. However, plants, just as humans and animals, are attacked by pathogens that cause a myriad of symptoms that can lead to reduced yields, lower quality products and diminished nutritional value. Plant pathogens share many features with their human and animal counterparts. Some pathogens - whether of humans, animals, or plants - have nimble genomes or the ability to pirate genes from other organisms via mobile elements. Some have developed the ability to cross kingdoms in their host ranges. Many others share virulence factors, such as the type III secretion system (T3SS) or mechanisms for sensing population density, that work equally well in all kingdoms. Certain pathogens of hosts in all kingdoms rely upon insect vectors and use similar mechanisms to ensure dispersal (and sometimes survival) in this way. Plant-pathogen interactions have more direct consequence for humans when the microbes are human pathogens such as Escherichia coli 0157:H7 and Salmonella spp., which can contaminate fresh produce or when they produce metabolites, such as mycotoxins, which are harmful when consumed. Finally, national biosecurity concerns and the need for prevention, preparedness and forensic capabilities cross all kingdom barriers. Thus, our communities that focus on one of these kingdoms have much to learn from one another and a complete and balanced ‘One Health’ initiative must be tripartite, embracing the essential components of healthy plants, healthy animals and healthy people.

This chapter explores the trajectories of two traditions of thinking about godlessness, which move in opposite directions in the 1970s and 1980s: the jeremiad tradition and the social scientific tradition. During this period, evangelicals and fundamentalists forcefully reasserted themselves in public life after decades of self‐imposed exile animated in part by stories of secularization and moral decay told by leaders Francis Schaeffer and Jerry Falwell. They entered the 1990s with new confidence and renewed hope. Many sociologists of religion, by contrast, were surprised by the surge of new religious energy and mobilization. They lost confidence in their predictions of religious decline and basic assumptions about the triumph of scientific rationalism. By the 1990s, consensus on their “secularization thesis” had collapsed.

One of the James Webb Space Telescope's (JWST) primary science goals is to characterize the epoch of galaxy formation in the universe and observe the first galaxies and clusters of galaxies. This goal requires multi-band imaging and spectroscopic data in the near infrared portion of the spectrum for large numbers of very faint galaxies. Because such objects are sparse on the sky at the JWST resolution, a multi-object spectrograph is necessary to efficiently carry out the required observations. We have developed a fully programmable array of microshutters that will be used as the field selector for the multi-object Near Infrared Spectrograph (NIRSpec) on JWST. This device allows apertures to be opened at the locations of selected galaxies in the field of view while blocking other unwanted light from the sky background and bright sources. In practice, greater than 100 objects within the field of view can be observed simultaneously. This field selection capability greatly improves the sensitivity and efficiency of NIRSpec. In this paper, we describe the microshutter arrays, their development, characteristics, fabrication, testing, and progress toward delivery of a flight-qualified field selection subsystem to the NIRSpec instrument team.

Two-dimensional MEMS microshutter arrays are being developed at NASA Goddard Space Flight Center for use in the near-infrared region on the James Webb Space Telescope (JWST). The microshutter arrays are designed for the selective transmission of light with high efficiency and high contrast. The JWST environment requires cryogenic operation at 35K. Microshutter arrays are fabricated out of silicon-oxide-insulated (SOI) silicon wafers. Arrays are close-packed silicon nitride membranes with a pixel size of 100x200 p. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. The mechanical shutter arrays are fabricated using MEMS technologies. The processing includes a multi- layer metal deposition and patterning of shutter electrodes and magnetic pads, reactive ion etching (NE) of the front side to form shutters out of the nitride membrane, an anisotropic back-etch for wafer thinning, followed by a deep RIE (DRIE) back-etch down to the nitride shutter membrane to form W e s and relieve shutters from the silicon substrate. An additional metal deposition and patterning is used to form back electrodes. Shutters are actuated using a magnetic force and latched using an electrostatic force. . . . KEYWORDS: microshutter, MEMS, RIE, DRIE, micro-optics, near inbred, space telescope

Micro Electromechanical System (MEMS) microshutter arrays are being developed at NASA Goddard Space Flight Center for use as a field selector of the Near Infrared Spectrograph (NIRSpec) on the James Webb Space Telescope (JWST). The microshutter arrays are designed for the spontaneous selection of a large number of objects in the sky and the transmission of light to the NIRSpec detector with high contrast. The JWST environment requires cryogenic operation at 35 K. Microshutter arrays are fabricated out of silicon-on-insulator (SOI) silicon wafers. Arrays are close-packed silicon nitride membranes with a pixel size of 100 x 200 μm. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. Light shields are processed for blocking light from gaps between shutters and frames. The mechanical shutter arrays are fabricated using MEMS technologies. The processing includes multi-layer metal depositions, the patterning of magnetic stripes and shutter electrodes, a reactive ion etching (RIE) to form shutters out of the nitride membrane, an anisotropic back-etch for wafer thinning, followed by a deep RIE (DRIE) back-etch to form mechanical supporting grids and release shutters from the silicon substrate. An additional metal deposition is used to form back electrodes. Shutters are actuated by a magnetic force and latched using an electrostatic force. Optical tests, addressing tests, and life tests are conducted to evaluate the performance and the reliability of microshutter arrays.

Magnetically actuated MEMS microshutter arrays are being developed at the NASA Goddard Space Flight Center for use in a multi-object spectrometer on the James Webb Space Telescope (JWST), formerly Next Generation Space Telescope (NGST). The microshutter arrays are designed for the selective transmission of light with high efficiency and high contrast. The JWST environment requires cryogenic operation at 45K. Microshutter arrays are fabricated out of silicon-on-insulator (SOI) wafers. Arrays consist of close-packed shutters made on silicon nitride (nitride) membranes with a pixel size of 100 × 100 m. Individual shutters are patterned with a torsion flexure permitting shutters to open 90°, with a minimized mechanical stress concentration. Shutters operated this way have survived fatigue life test. The mechanical shutter arrays are fabricated using MEMS technologies. The processing includes a multi-layer metal deposition, patterning of shutter electrodes and magnetic pads, reactive ion etching (RIE) of the front side to form shutters in a nitride film, an anisotropic back-etch for wafer thinning, and a deep RIE (DRIE) back-etch, down to the nitride shutter layer, to form support frames and relieve shutters from the silicon substrate. An additional metal deposition and patterning has recently been developed to form electrodes on the vertical walls of the frame. Shutters are actuated using a magnetic force, and latched electrostatically. One-dimensional addressing has been demonstrated.

Two-dimensional microshutter arrays are being developed at NASA Goddard Space Flight Center (GSFC) for the Next Generation Space Telescope (NGST) for use in the near-infrared region. Functioning as focal plane object selection devices, the microshutter arrays are 2-D programmable masks with high efficiency and high contrast. The NGST environment requires cryogenic operation at 45 K. Arrays are close-packed silicon nitride membranes with a unit cell size of 100x100 micrometer. Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with minimized mechanical stress concentration. The mechanical shutter arrays are fabricated with MEMS technologies. The processing includes a RIE front-etch to form shutters out of the nitride membrane, an anisotropic back-etch for wafer thinning, and a deep RIE (DRIE) back-etch down to the nitride shutter membrane to form frames and to relieve the shutters from the silicon substrate. A layer of magnetic material is deposited onto each shutter. Onto the side-wall of the support structure a metal layer is deposited that acts as a vertical hold electrode. Shutters are rotated into the support structure by means of an external magnet that is swept across the shutter array for opening. Addressing is performed through a scheme using row and column address lines on each chip and external addressing electronics.

Two-dimensional microshutter arrays are being developed at NASA Goddard Space Flight Center for the Next Generation Space Telescope (NGST) for use in the near-infrared region. Functioning as object selection devices, the microshutter arrays are designed for the transmission of light with high efficiency and high contrast. The NGST environment requires cryogenic operation at 45K. Arrays are close-packed silicon nitride membranes with a pixel size of 100 X 100 micrometers . Individual shutters are patterned with a torsion flexure permitting shutters to open 90 degrees with a minimized mechanical stress concentration. The mechanical shutter arrays are fabricated with MEMS technologies. The processing includes a RIE front-etch to form shutters out of the nitride membrane, an anisotropic back-etch for wafer thinning, and a deep RIE (DRIE) back-etch down to the nitride shutter membrane to form frames and to relieve shutters from the silicon substrate. Two approaches for shutter actuation have been developed. Shutters are actuated using either a combined mechanical and electrostatic force or a combined magnetic and electrostatic force. A CMOS circuit embedded in the frame between shutters allows programmable shutter selection for the first approach. A control of row and column electrodes fulfills shutter selection for the second approach.

We report on the design, fabrication and characterization of a back-illuminated voltage bias selectable dual-band AlGaN UV photodetector. The photodetector can separate UVA and W-B band radiation by bias switching a two terminal n-p-n homojunction structure that is fabricated in the same pixel. When a forward bias is applied between the top and bottom electrodes, the detector can sense UV-A and reject W-B band radiation. Alternatively, under reverse bias, the photodetector can sense UV-B and reject UV-A band radiation.

Using conventional photolithography, Al 0.35 Ga 0.65 N pin diodes have been fabricated that exhibit extremely low reverse bias leakage currents. Macroscopic I-V measurements from a statistical population of 64, 120 μm diameter, circular diodes gives a mean leakage current of 0.96 fA with a standard deviation of 0.90 fA at -0.5 V bias.

Pt/n-type GaN Schottky photodiodes with large active areas which exhibit low leakage currents are fabricated. Reverse bias leakage currents of 2.7 nA for a 1 cm2 diode and 14 pA for a 0.25 cm2 diode both at −0.5 V bias are reported. External quantum efficiency measurements between the spectral range 50 to 500 nm gave a peak responsivity of 77.5 mA/W at 320 nm for a 0.25 cm2 diode, corresponding to a spectral detectivity, D*=1.5×1014 cmHz1/2W−1.

Tactical service scheduling and operational cargo allocation are two interdependent problems in liner shipping. The schedules and sailing speeds of individual liner shipping services and the synchronization among all services determine the transit times of containers through a liner shipping network. On the other hand, the market demand in terms of container volume and expected transit times between origin and destination ports drive the schedule design of liner shipping services. We present a graph-based model and a branch-and-price algorithm to solve the combined problem. The goal is to minimize the difference between fuel consumption costs and revenues from transporting containers under consideration of transit time limits. Fuel consumption is modeled as a function of both speed and payload. Results are presented for 12 liner shipping networks and emphasize the importance of explicitly modeling schedules in large networks; transshipment times and thus transit times may be severely miscalculated otherwise. The results further show that neglecting payload in the fuel consumption function can result in suboptimal service schedules and cargo routing decisions.

In large liner shipping networks, several hundred container vessels operate 24/7,following planned routes and timetables. These networks constantly face unexpected disruptions of varying magnitude. Among the most common reasons are bad weather, port congestions, labour strikes or equipment breakdowns at ports or on vessels. Disruptions may result in delayed vessels, temporarily disabled vessels, reduced port productivity, and port closures. Due to the cargo-driven connectivity of liner shipping networks, even a single delayed vessel can create ripple effects that affect multiple other vessels. Resolving disruptions is a trade-off between minimizing operational vessel costs and port call costs on one side, and minimizing the impact on cargo, such as delays andre-routings, on the other side. We present a model and solution method that generates a set of recovery plans for the decision maker. We present preliminary results for testcases that were developed together with our industrial collaborator Mærsk. We will further discuss various challenges that arise in practice - such as incomplete information and intangible costs - and how we deal with those.

In large liner shipping networks, several hundred container vessels operate 24/7, following planned routes and timetables. These networks constantly face unexpected disruptions of varying magnitude. Among the most common reasons are bad weather, port congestions, labour strikes or equipment breakdowns at ports or on vessels. Disruptions may result in delayed vessels, temporarily disabled vessels, reduced port productivity, and port closures. Due to the cargo-driven connectivity of liner shipping networks, even a single delayed vessel can create ripple effects that affect multiple other vessels. Resolving disruptions is a trade-off between minimizing operational vessel costs and port call costs on one side, and minimizing the impact on cargo, such as delays and re-routings, on the other side. One difficulty of finding a good trade-off arises from the fact that cargo related costs are largely not tangible or directly quantifiable, such as lost reputation and customer churn. Incomplete information during the planning of recovery plans adds another challenge: ports may reject a revised vessel schedule if no berthing window is available, resulting in multiple iterations of recovery planning. We present a model and solution method that generates a set of recovery plans for the decision maker. We present preliminary results for test cases that were developed together with our industrial collaborator Maersk.

The two main challenges of optimizing a wind farm are the design of the turbine layout and the design of the cable routing. The first task consists in placing each turbine such that overall power production is maximized, the wake effect (wind shadow) between turbines is minimized, and foundation costs are minimized as well. The second task is to select the minimum cost cable routing to connect the turbines with submarine cables, which transfer the produced electricity to a substation and then onshore. Although the typical procedure is to solve the two problems sequentially, we investigate the benefit of solving them together. Few studies in the literature attempt to join these two optimization problems, which are often simplified to keep the computational complexity low. In our work, we model the combined problem with all constraints relevant to practical applications of wind farm design. We also present a novel local search that integrates the two problems, thus allowing the cable routing to give direct feedback to the turbine positions in the layout. We benchmark the combined optimization on a set of realistic industry-scale wind farm instances. Our results show that the combined optimization outperforms the sequential approach, especially for lower energy density wind farms, due to the significant savings in the cable routing which widely compensate for a slight reduction in power production.