67 results on '"Chundong Zhang"'
Search Results
2. PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation
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Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, and Guoxiang Jin
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Cancer Research ,Cellular and Molecular Neuroscience ,Immunology ,Cell Biology - Abstract
Necroptosis plays a double-edged sword role in necroptotic cancer cell death and tumor immune escape. How cancer orchestrates necroptosis with immune escape and tumor progression remains largely unclear. We found that RIP3, the central activator of necroptosis, was methylated by PRMT1 methyltransferase at the amino acid of RIP3 R486 in human and the conserved amino acid R479 in mouse. The methylation of RIP3 by PRMT1 inhibited the interaction of RIP3 with RIP1 to suppress RIP1-RIP3 necrosome complex, thereby blocking RIP3 phosphorylation and necroptosis activation. Moreover, the methylation-deficiency RIP3 mutant promoted necroptosis, immune escape and colon cancer progression due to increasing tumor infiltrated myeloid-derived immune suppressor cells (MDSC), while PRMT1 reverted the immune escape of RIP3 necroptotic colon cancer. Importantly, we generated a RIP3 R486 di-methylation specific antibody (RIP3ADMA). Clinical patient samples analysis revealed that the protein levels of PRMT1 and RIP3ADMA were positively correlated in cancer tissues and both of them predicted the longer patient survival. Our study provides insights into the molecular mechanism of PRMT1-mediated RIP3 methylation in the regulation of necroptosis and colon cancer immunity, as well as reveals PRMT1 and RIP3ADMA as the valuable prognosis markers of colon cancer.
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- 2023
3. RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation
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Lian Zhang, Jing Yu, Mingyue Zheng, Hui Zhen, Qingqiang Xie, Chundong Zhang, Zhongjun Zhou, and Guoxiang Jin
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Medicine (miscellaneous) ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Abstract
CD47 is a macrophage-specific immune checkpoint protein acting by inhibiting phagocytosis. However, the underlying mechanism maintaining CD47 protein stability in cancer is not clear. Here we show that CD47 undergoes degradation via endocytosis/lysosome pathway. The lysosome protein RAGA interacts with and promotes CD47 lysosome localization and degradation. Disruption of RAGA blocks CD47 degradation, leading to CD47 accumulation, high plasma membrane/intracellular CD47 expression ratio and reduced phagocytic clearance of cancer cells. RAGA deficiency promotes tumor growth due to the accumulation of CD47, which sensitizes the tumor to CD47 blockade. Clinical analysis shows that RAGA and CD47 proteins are negatively correlated in lung adenocarcinoma patient samples. High RAGA protein level is related to longer patient survival. In addition, RAGAhighCD47low patients show the longest overall survival. Our study thereby not only reveals a mechanism by which RAGA regulates CD47 lysosome degradation, but also suggests RAGA is a potential diagnostic biomarker of lung adenocarcinoma.
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- 2023
4. Direct hydrogenation of CO2 into valuable aromatics over K/Fe-Cu-Al @HZSM-5 tandem catalysts: Effects of zeolite surface acidity on aromatics formation
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Chundong Zhang, Kehao Hu, Xixi Chen, Lujing Xu, Chao Deng, Qiang Wang, Ruxing Gao, Ki-Won Jun, Seok Ki Kim, Tiansheng Zhao, Hui Wan, and Guofeng Guan
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Fuel Technology ,General Chemical Engineering ,Energy Engineering and Power Technology - Published
- 2023
5. Correction: DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer
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Longhao Li, Chundong Zhang, Yi Li, Ying Zhang, and Yunlong Lei
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General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Published
- 2023
6. Investigation on the Isobaric Vapor–Liquid Equilibrium for the Binary Systems of Ethyl Benzoate with Xylene Isomers and Ethylbenzene
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Jiahai Ding, Wei Guan, Leiyu Zhang, Xiudong Zhang, Chundong Zhang, Lei Wang, Hui Wan, and Guofeng Guan
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General Chemical Engineering ,General Chemistry - Published
- 2021
7. Intratumoral immune heterogeneity of prostate cancer characterized by typing and hub genes
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Jianpeng Han, Yan Zhou, Chundong Zhang, Jianyong Feng, Junhao Wang, Kuo Guo, Wenbin Chen, and Yongzhang Li
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Male ,Carcinoma ,Molecular Medicine ,Humans ,Prostatic Neoplasms ,Cell Biology ,Social Group ,Algorithms ,Hormones - Abstract
Discordant abundances of different immune cell subtypes is regarded to be an essential feature of tumour tissue. Direct studies in Prostate cancer (PC) of intratumoral immune heterogeneity characterized by immune cell subtype, are still lacking. Using the single sample gene set enrichment analysis (ssGSEA) algorithm, the abundance of 28 immune cells infiltration (ICI) were determined for PC. A NMF was performed to determine tumour-sample clustering based on the abundance of ICI and PFS information. Hub genes of clusters were identified via weighted gene co-expression network analysis (WGCNA). The multivariate dimensionality reduction analysis of hub genes expression matrix was carried out via principal component analysis (PCA) to obtain immune score (IS). We analysed the correlation between clustering, IS and clinical phenotype. We divided the 495 patients into clusterA (n = 193) and clusterB (n = 302) on the basis of ICI and PFS via NMF. The progression-free survival (PFS) were better for clusterA than for clusterB (p 0.001). Each immune cell subtypes was more abundant in clusterA than in clusterB (p 0.001). The expression levels of CTAL-4 and PD-L1 were lower in clusterB than in clusterA (p 0.001 and p = 0.006). We obtained 103 hub genes via WGCNA. In the training and validation cohorts, the prognosis of high IS group was worse than that of the low IS group (p 0.05). IS had good predictive effect on 5-year PFS. The expression of immune checkpoint genes was higher in the low IS group than in the high IS group (p 0.01). Patients with low IS and receiving hormone therapy had better prognosis than other groups. The combination of IS and clinical characteristics including lymph node metastasis and gleason score can better differentiate patient outcomes than using it alone. IS was a practical algorithm to predict the prognosis of patients. Advanced PC patients with low IS may be more sensitive to hormone therapy. CXCL10, CXCL5, MMP1, CXCL12, CXCL11, CXCL2, STAT1, IL-6 and TLR2 were hub genes, which may drive the homing of immune cells in tumours and promote immune cell differentiation.
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- 2022
8. Conceptual design of full carbon upcycling of CO2 into clean DME fuel: Techno-economic assessment and process optimization
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Ruxing Gao, Leiyu Zhang, Lei Wang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Tiansheng Zhao, Hui Wan, and Guofeng Guan
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Fuel Technology ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology - Published
- 2023
9. Life cycle sustainability decision-support framework for CO2 chemical conversion technologies under uncertainties
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Ruxing Gao, Lei Wang, Leiyu Zhang, Chundong Zhang, Tao Liu, Ki-Won Jun, Seok Ki Kim, Ying Gao, Tiansheng Zhao, Hui Wan, and Guofeng Guan
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Fuel Technology ,Nuclear Energy and Engineering ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology - Published
- 2023
10. A multi-criteria sustainability assessment and decision-making framework for DME synthesis via CO2 hydrogenation
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Ruxing Gao, Lei Wang, Leiyu Zhang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Tiansheng Zhao, Hui Wan, Guofeng Guan, and Yuezhao Zhu
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General Energy ,Mechanical Engineering ,Building and Construction ,Electrical and Electronic Engineering ,Pollution ,Industrial and Manufacturing Engineering ,Civil and Structural Engineering - Published
- 2023
11. rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS
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Ying Zhang, Yishu Tang, Youquan Bu, Chundong Zhang, Yunlong Lei, Yiling Liu, and Deqian Qiao
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General Immunology and Microbiology ,General Medicine ,General Biochemistry, Genetics and Molecular Biology - Published
- 2023
12. Benchmarking promoters of Fe/activated carbon catalyst for stable hydrogenation of CO2 to liquid hydrocarbons
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Jingyu Chen, Seung Ju Han, Hae-Gu Park, Khasan Nasriddinov, Chundong Zhang, Ki-Won Jun, and Seok Ki Kim
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Process Chemistry and Technology ,Catalysis ,General Environmental Science - Published
- 2023
13. Efficient utilization of CO2 in power-to-liquids/power-to-gas hybrid processes: An economic-environmental assessment
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Ruxing Gao, Leiyu Zhang, Lei Wang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Hae-Gu Park, Tiansheng Zhao, Hui Wan, and Guofeng Guan
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Process Chemistry and Technology ,Chemical Engineering (miscellaneous) ,Waste Management and Disposal - Published
- 2023
14. Proline-rich 11 (PRR11) drives F-actin assembly by recruiting the actin-related protein 2/3 complex in human non-small cell lung carcinoma
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Zhili Wei, Ying Zhang, Chundong Zhang, Yi Li, Youquan Bu, Yunlong Lei, Lian Zhang, and Yingxiong Wang
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0301 basic medicine ,Lung Neoplasms ,Arp2/3 complex ,macromolecular substances ,Biochemistry ,03 medical and health sciences ,Carcinoma, Non-Small-Cell Lung ,Humans ,Cytoskeleton ,Molecular Biology ,Actin ,Binding Sites ,030102 biochemistry & molecular biology ,biology ,Actin-Related Protein 2-3 Complex ,Chemistry ,Proteins ,Cell Biology ,Actin cytoskeleton ,Actins ,Cell biology ,Chromatin ,030104 developmental biology ,A549 Cells ,Cytoplasm ,Actin-Related Protein 3 ,Actin-Related Protein 2 ,biology.protein ,Nuclear lamina ,Protein Multimerization ,Protein Binding - Abstract
The actin cytoskeleton is extremely dynamic and supports diverse cellular functions in many physiological and pathological processes, including tumorigenesis. However, the mechanisms that regulate the actin-related protein 2/3 (ARP2/3) complex and thereby promote actin polymerization and organization in cancer cells are not well-understood. We previously implicated the proline-rich 11 (PRR11) protein in lung cancer development. In this study, using immunofluorescence staining, actin polymerization assays, and siRNA-mediated gene silencing, we uncovered that cytoplasmic PRR11 is involved in F-actin polymerization and organization. We found that dysregulation of PRR11 expression results in F-actin rearrangement and nuclear instability in non-small cell lung cancer cells. Results from molecular mechanistic experiments indicated that PRR11 associates with and recruits the ARP2/3 complex, facilitates F-actin polymerization, and thereby disrupts the F-actin cytoskeleton, leading to abnormal nuclear lamina assembly and chromatin reorganization. Inhibition of the ARP2/3 complex activity abolished irregular F-actin polymerization, lamina assembly, and chromatin reorganization due to PRR11 overexpression. Notably, experiments with truncated PRR11 variants revealed that PRR11 regulates F-actin through different regions. We found that deletion of either the N or C terminus of PRR11 abrogates its effects on F-actin polymerization and nuclear instability and that deletion of amino acid residues 100–184 or 100–200 strongly induces an F-actin structure called the actin comet tail, not observed with WT PRR11. Our findings indicate that cytoplasmic PRR11 plays an essential role in regulating F-actin assembly and nuclear stability by recruiting the ARP2/3 complex in human non-small cell lung carcinoma cells.
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- 2020
15. Mesoporous carbon as an effective support for Fe catalyst for CO2 hydrogenation to liquid hydrocarbons
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Sun-Mi Hwang, Seok Ki Kim, Sunkyu Yang, Ki-Won Jun, Chundong Zhang, Seung Ju Han, Yong-Tae Kim, and Hae-Gu Park
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chemistry.chemical_classification ,Chemistry ,Process Chemistry and Technology ,Diffusion ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Liquid hydrocarbons ,Hydrocarbon ,Mesoporous carbon ,Chemical engineering ,Phase (matter) ,Chemical Engineering (miscellaneous) ,0210 nano-technology ,Selectivity ,Waste Management and Disposal - Abstract
Identifying highly efficient catalysts for direct CO2 hydrogenation to liquid hydrocarbons is crucial for CO2 utilization via chemical conversion using renewable resources, the so-called Power-to-Liquids. In this study, well-defined mesoporous carbon (MPC) of 6.9 nm pore size was synthesized as a support material for Fe oxycarbide nanoparticles, which serve as active sites for the CO2 hydrogenation reaction, combining reverse water-gas shift and Fischer-Tropsch reactions. The unique physicochemical properties of MPC favored the formation of an active carbidic Fe phase and the rapid diffusion of produced hydrocarbons which resulted in an enhanced CO2 conversion and long-chain hydrocarbon selectivity. As a result, the MPC supported Fe catalyst showed C5+ hydrocarbon selectivity of 44.5% with a CO2 conversion rate of 50.6% (300 °C, 2.5 MPa, H2/CO2 = 3).
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- 2020
16. Identification of active sites for CO2 hydrogenation in Fe catalysts by first-principles microkinetic modelling
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Ki-Won Jun, Chundong Zhang, Sun-Mi Hwang, Seok Ki Kim, Seung Ju Han, and Hae-Gu Park
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Reaction mechanism ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Binding energy ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Heterogeneous catalysis ,01 natural sciences ,Dissociation (chemistry) ,0104 chemical sciences ,Catalysis ,Reaction rate ,Computational chemistry ,Active phase ,General Materials Science ,Computational analysis ,0210 nano-technology - Abstract
Active phase and reaction mechanism identification is imperative when designing catalysts for target reactions. Although computational analysis often suggests effective methods, the complexity and computational cost can be problematic, especially for Fe-based catalysts with various oxidation numbers. Herein, we elucidated the Fe phase involved in CO2 hydrogenation through a density-functional-theory-based energetics study and suggested promoters by performing microkinetic analysis. Our theoretical model suggested that (1) Fe3O4 is a major active phase for the reverse water–gas shift (RWGS) reaction; (2) direct dissociation of CO2 is preferred over hydrogenation; and (3) surface oxygen removal determines the overall reaction rate over most Fe surfaces. Using CO2 and OH binding energies as activity descriptors to screen promoters, Cu and Zn were found to accelerate the RWGS rate by facilitating OH removal. The proposed microkinetic modelling approach will aid in predicting complex heterogeneous catalysis processes involving diverse intermediates and surface phase transitions.
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- 2020
17. [Corrigendum] The Pleckstrin and Sec7 domain-containing gene as a novel epigenetic modification marker in human gastric cancer and its clinical significance
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Xinjiang Zhu, Jian Liu, Xiaoyang Xu, Chundong Zhang, and Dongqiu Dai
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Cancer Research ,Oncology - Published
- 2022
18. Enhancing Selectivity of Aromatics in Direct Conversion of Syngas Over K/Femn and Hzsm-5 Bifunctional Catalysts
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Seok Chang Kang, Gyungah Park, Geunjae Kwak, Chundong Zhang, Ki-Won Jun, Yong Tae Kim, and Minkee Choi
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Process Chemistry and Technology ,Physical and Theoretical Chemistry ,Catalysis - Published
- 2022
19. Establishment of Mathematical Model of Different Burr Removal Methods for Automobile Valve Body Parts
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Chundong Zhang
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History ,Computer Science Applications ,Education - Abstract
In the process of auto body parts processing, machining surface at the junction will produce burrs or flares. The existence of burr will have a bad effect on the machining accuracy, assembly accuracy and appearance quality of parts. In industrial production, the cost of removing these burrs is enormous. In automotive parts, the cost of deburring body parts can account for machining costs15% - 20%. Industry practice has shown that the actual cost of deburring systems increases as the complexity and accuracy of parts increase. Precision parts such as automobile valve body require high precision, and burr is usually removed by grinding. In grinding process, different types of burr will adopt different grinding process to purify, frequent adjustment process will affect the production efficiency, so the combination with the characteristics of grinding, the grinding grain edge radius, equivalent negative rake Angle and other factors into consideration, burr types can be divided into three categories, respectively on the three types of burr mathematical modeling, The removal mechanism of different kinds of burr is explained theoretically, which lays a theoretical foundation for improving efficiency in production practice.
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- 2023
20. Active and selective reverse water-gas shift reaction over Pt/Na-Zeolite catalysts
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Jeong-Cheol Seo, Gyungah Park, Malik Waqar Arshad, Chundong Zhang, Sungtak Kim, and Seok Ki Kim
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History ,Polymers and Plastics ,Process Chemistry and Technology ,Chemical Engineering (miscellaneous) ,Business and International Management ,Waste Management and Disposal ,Industrial and Manufacturing Engineering - Published
- 2022
21. Optimization and Control for Separation of Ethyl Benzene from C8 Aromatic Hydrocarbons with Extractive Distillation
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Jincheng Pan, Jiahai Ding, Chundong Zhang, Hui Wan, and Guofeng Guan
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C8 aromatic hydrocarbons ,extractive distillation ,genetic algorithm ,TAC ,dynamic simulation ,Process Chemistry and Technology ,Chemical Engineering (miscellaneous) ,Bioengineering - Abstract
Extractive distillation has great significance for the separation of ethylbenzene from C8 aromatic hydrocarbons. Herein, a distillation process for the separation of ethylbenzene was designed using methyl phenylacetate as an extractant. A genetic algorithm (GA) was used to evaluate the economic and environmental factors of the process, and Aspen Dynamic was used to assess the dynamic performance. The sequential optimization method was used to obtain the initial process parameters. Then, the total annual cost and CO2 emissions were minimized by NSGA-III to increase the economic and environmental benefits. To enhance the search performance of GA, the mutation probability and crossover probability were studied and adjusted. The optimal total annual cost and CO2 emissions were 11.7% and 23.7% lower than those of the initial process. Based on a steady process, two control strategies, which were the flow rate of the recycling solvent controlled by entrainer makeup flow rate (CS1) and the bottom flow rate of the extractant recovery column (CS2), were designed. The results showed that the temperature deviation of CS2 was smaller than that of CS1, and the temperature of the process was more stable under the control of CS2.
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- 2022
22. Upcycling of CO2 into sustainable hydrocarbon fuels via the integration of Fe-based Fischer-Tropsch synthesis and olefin oligomerization: A comparative case study
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Ruxing Gao, Lei Wang, Leiyu Zhang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Hae-Gu Park, Tiansheng Zhao, Ying Gao, Yuezhao Zhu, Hui Wan, and Guofeng Guan
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Fuel Technology ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology - Published
- 2022
23. Hydrogenation of Carbon Dioxide to Value-Added Liquid Fuels and Aromatics over Fe-Based Catalysts Based on the Fischer–Tropsch Synthesis Route
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Qiang Wang, Kehao Hu, Ruxing Gao, Leiyu Zhang, Lei Wang, and Chundong Zhang
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Atmospheric Science ,Environmental Science (miscellaneous) - Abstract
Hydrogenation of CO2 to value-added chemicals and fuels not only effectively alleviates climate change but also reduces over-dependence on fossil fuels. Therefore, much attention has been paid to the chemical conversion of CO2 to value-added products, such as liquid fuels and aromatics. Recently, efficient catalysts have been developed to face the challenge of the chemical inertness of CO2 and the difficulty of C–C coupling. Considering the lack of a detailed summary on hydrogenation of CO2 to liquid fuels and aromatics via the Fischer–Tropsch synthesis (FTS) route, we conducted a comprehensive and systematic review of the research progress on the development of efficient catalysts for hydrogenation of CO2 to liquid fuels and aromatics. In this work, we summarized the factors influencing the catalytic activity and stability of various catalysts, the strategies for optimizing catalytic performance and product distribution, the effects of reaction conditions on catalytic performance, and possible reaction mechanisms for CO2 hydrogenation via the FTS route. Furthermore, we also provided an overview of the challenges and opportunities for future research associated with hydrogenation of CO2 to liquid fuels and aromatics.
- Published
- 2022
24. Analysis of the application of contrast-enhanced ultrasound-guided prostate biopsy in early diagnosis of prostate cancer
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Heping Deng, Yiman Guan, Qinmao Fang, Bo Zhang, Xia Wu, Chundong Zhang, Weiwei Zhang, and Meicong Feng
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medicine.medical_specialty ,Prostate cancer ,Prostate biopsy ,medicine.diagnostic_test ,business.industry ,medicine ,General Medicine ,Radiology ,business ,medicine.disease ,Contrast-enhanced ultrasound - Published
- 2021
25. Prognosis values of modified Lauren classification in gastric cancer: a validation from SEER database
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Masanobu Abe, Jun Wang, Yan Zhao, Chundong Zhang, Nan-Nan Zhang, Fei-Long Ning, Hong-Guang Quan, Junpeng Pei, Yi-Feng Jin, and Xian-Tao Zeng
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Oncology ,medicine.medical_specialty ,genetic structures ,business.industry ,Internal medicine ,Seer database ,medicine ,Lauren classification ,Cancer ,business ,medicine.disease - Abstract
Background: It remains controversial as to which pathological classification is most valuable in predicting overall survival (OS) in patients with gastric cancer (GC). We assessed the prognostic performances of three pathological classifications in GC and developed a novel prognostic nomogram individually predicting OS. Methods: Patients were identified from the Surveillance, Epidemiology and End Results program. Univariate and multivariate analyses were performed to identify the independent prognostic factors. Model discrimination and model-fitting were evaluated by receiver operating characteristic curves and Akaike information criteria. Decision curve analysis was performed to assess clinical usefulness. The independent prognostic factors identified by multivariate analysis were further applied to develop a novel prognostic nomogram. Results: A total of 2,718 eligible GC patients were identified. The modified Lauren classification was identified as one of the independent prognostic factors of OS. It showed superior model discriminative ability and model-fitting performance over the other pathological classifications, and similar results were obtained in various patient settings. In addition, it showed superior net benefits over the Lauren classification and tumor differentiation grade in predicting 3- and 5-year OS. A novel prognostic nomogram incorporating the modified Lauren classification showed superior model discriminative ability, model-fitting performance, and net benefits over the American Joint Committee on Cancer (AJCC) 8th Edition TNM classification. Conclusion: The modified Lauren classification showed superior net benefits over the Lauren classification and tumor differentiation grade in predicting OS. A novel prognostic nomogram incorporating the modified Lauren classification showed good model discriminative ability, model-fitting performance, and net benefits.
- Published
- 2021
26. Light hydrocarbons to BTEX aromatics over Zn-modified hierarchical ZSM-5 combined with enhanced catalytic activity and stability
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Ruxing Gao, Guofeng Guan, Hae-Gu Park, Seok Chang Kang, Ki-Won Jun, Sungtak Kim, Yun-Jo Lee, Geunjae Kwak, Chundong Zhang, and Ji-Eun Min
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Chemistry ,Inorganic chemistry ,Aromatization ,02 engineering and technology ,General Chemistry ,BTEX ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Alkali metal ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Mechanics of Materials ,Yield (chemistry) ,General Materials Science ,ZSM-5 ,0210 nano-technology ,Mesoporous material ,Brønsted–Lowry acid–base theory - Abstract
A series of Zn modified hierarchical ZSM-5 catalysts with Si/Al ratios of 25 and 40, and Zn loading amounts of 0, 0.5, 1, and 2 wt% was designed to pursue a highly efficient catalyst with excellent catalytic activity and stability toward BTEX formation in the aromatization of light hydrocarbons. The Zn modified hierarchical ZSM-5 catalysts with intracrystalline mesopores were prepared by alkali treatment and Zn impregnation. The effects of the alkali treatment and Zn modification on the textural property, acidity, catalytic performance, and coke formation were investigated in detail via various characterization techniques. It was found that the catalytic stability of the alkali-treated catalysts notably improved. This can be mainly attributed to the fact that the alkali treatment of the pre-synthesized ZSM-5 generated a large amount of mesopores, which could alleviate the diffusion limitations. Moreover, the Zn modification remarkably improved the initial BTEX yield, which was due to the improved Lewis/Bronsted (L/B) ratio in the prepared catalysts. However, as the Zn loading amount increased from 0 to 2 wt%, the catalyst stability dramatically decreased, especially for the 2 wt% case. It seems that the balance between the Lewis and Bronsted acid sites (i.e., the suitable L/B ratio) is the key to obtaining both high BTEX yield and catalyst stability, and the optimum Zn loading amount is determined to be 0.5 wt% with an L/B ratio of around 1.
- Published
- 2019
27. Light hydrocarbons to BTEX aromatics over hierarchical HZSM-5: Effects of alkali treatment on catalytic performance
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Sungtak Kim, Seok Chang Kang, Yun-Jo Lee, Hae-Gu Park, Geunjae Kwak, Chundong Zhang, and Ki-Won Jun
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chemistry.chemical_classification ,Ethylene ,Chemistry ,Aromatization ,02 engineering and technology ,General Chemistry ,Coke ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Hydrocarbon ,Adsorption ,Chemical engineering ,Mechanics of Materials ,Desorption ,General Materials Science ,0210 nano-technology ,Zeolite - Abstract
Three HZSM-5 zeolites with initial Si/Al ratios of 15, 25, and 40 were treated using an alkali solution to establish a hierarchical micropore-mesopore interconnected structure in alkali-treated zeolite samples Z15-AT, Z25-AT, and Z40-AT, respectively. The aim of the present work is to improve the catalytic stability in the aromatization of ethylene, a model compound representing the light hydrocarbons produced by the high-temperature Fischer‒Tropsch synthesis. By using characterization techniques, such as XRD, ICP, N2 adsorption/desorption, TEM, 27Al and 29Si MAS/NMR, NH3-TPD, Pyridine-IR, and TGA, we analyzed the textural property and acidity of the fresh catalysts, as well as the coke formation rate of the spent catalysts. The catalytic stability was shown to be successfully enhanced in the light hydrocarbon aromatization and the initial Si/Al ratio is a crucial factor for the mesopore formation and the catalytic performance. Among the prepared zeolite samples, the Z25-AT sample seemed to be the most suitable catalyst owing to its significant enhancement in the catalytic stability. The main reason for the improved stability by alkali treatment seems to be that the hierarchical pore structure facilitates the mass transfer and provides the additional space for carbon deposition as well, thus weakening the pore blocking and prolongs the lifetime of the catalyst.
- Published
- 2019
28. A comparative study on hybrid power-to-liquids/power-to-gas processes coupled with different water electrolysis technologies
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Ruxing Gao, Leiyu Zhang, Lei Wang, Xiudong Zhang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Hae-Gu Park, Ying Gao, Yuezhao Zhu, Tiansheng Zhao, Hui Wan, and Guofeng Guan
- Subjects
Fuel Technology ,Nuclear Energy and Engineering ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology - Published
- 2022
29. Energy-Efficient Methanol to Dimethyl Ether Processes Combined with Water-Containing Methanol Recycling: Process Simulation and Energy Analysis
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Geunjae Kwak, Chundong Zhang, Sungtak Kim, and Ki Won Jun
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Process modeling ,010405 organic chemistry ,Chemistry ,010402 general chemistry ,01 natural sciences ,Energy analysis ,0104 chemical sciences ,chemistry.chemical_compound ,General Energy ,Chemical engineering ,Dimethyl ether ,Methanol ,Process simulation ,Efficient energy use - Published
- 2018
30. Efficient Production of Renewable Hydrocarbon Fuels Using Waste CO2 and Green H2 by Integrating Fe-Based Fischer-Tropsch Synthesis and Olefin Oligomerization
- Author
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Ruxing Gao, Leiyu Zhang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Hae-Gu Park, Lei Wang, Hui Wan, and Guofeng Guan
- Published
- 2021
31. Association of Metabolic Syndrome and Its Components With Risk of Stroke Recurrence and Mortality: A Meta-analysis
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Lili Liu, Fangfang Zhang, Zubing Mei, Shiliang Ji, Chundong Zhang, and Tian Li
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Male ,medicine.medical_specialty ,Cochrane Library ,Recurrence ,Risk Factors ,Internal medicine ,Cause of Death ,medicine ,Humans ,Stroke ,Cause of death ,Aged ,Aged, 80 and over ,Metabolic Syndrome ,business.industry ,Middle Aged ,medicine.disease ,Confidence interval ,Relative risk ,Meta-analysis ,Female ,Neurology (clinical) ,Metabolic syndrome ,business ,Cohort study - Abstract
ObjectiveBecause metabolic syndrome is a significant risk factor for cardio-cerebrovascular diseases and the relationship between metabolic syndrome (including its components) and the prognosis of stroke is controversial, this study was conducted to evaluate whether metabolic syndrome is associated with a high recurrence and mortality of stroke.MethodsThis study was registered in the PROSPERO database (CRD42020177118). We searched for relevant observational cohort studies published from inception to April 23, 2020, using PubMed, Embase, and the Cochrane Library. Effect estimates with 95% confidence intervals (CIs) were pooled using the random-effects model. The primary and secondary outcomes were stroke recurrence and all-cause mortality, respectively. Leave-one-out sensitivity analyses and nonparametric trim-and-fill method were used to identify the stability of the results.ResultsThirteen cohort studies comprising 59,919 participants >60 years of age were included for analysis. Overall, metabolic syndrome was significantly associated with stroke recurrence (relative risk [RR] 1.46, 95% CI 1.07–1.97, p = 0.02). Among the metabolic syndrome components, low levels of high-density lipoprotein cholesterol (HDL-C) (RR 1.32, 95% CI 1.11–1.57, p = 0.002) and ≥2 metabolic syndrome components (RR 1.68, 95% CI 1.44–1.94, p < 0.001) significantly predicted stroke recurrence, whereas elevated triglycerides, elevated waist circumference, hyperglycemia, and hypertension failed to account for risk factors for stroke recurrence. Moreover, metabolic syndrome, not its components, was significantly associated with all-cause mortality (RR 1.27, 95% CI 1.18–1.36, p < 0.001). The stability of these results was further confirmed by the leave-one-out sensitivity analyses and nonparametric trim-and-fill method.ConclusionsThe present study indicates that metabolic syndrome and some of its components (low HDL-C and number of metabolic syndrome components) seem to be risk factors for stroke recurrence. Although metabolic syndrome is also associated with all-cause mortality, the role of its components in predicting all-cause mortality deserves further study.
- Published
- 2020
32. A Novel Prognostic Model Incorporating Carcinoembryonic Antigen in 3-Week or Longer Postoperative Period for Stage III Colon Cancer: A Multicenter Retrospective Study
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Jin Fan, Yanlong Liu, Xin Cai, Jingwen Wang, Rui Guo, Yuan Ji, Chao Li, Ye Xu, Xinxiang Li, Chundong Zhang, Rui Zhang, Ji Zhu, and Sanjun Cai
- Subjects
Cancer Research ,medicine.medical_specialty ,disease-free survival ,Colorectal cancer ,Urology ,lcsh:RC254-282 ,03 medical and health sciences ,tumor-node-metastasis staging ,0302 clinical medicine ,Carcinoembryonic antigen ,medicine ,030212 general & internal medicine ,Stage (cooking) ,Original Research ,biology ,business.industry ,carcinoembryonic antigen ,Hazard ratio ,prognostic factors ,Retrospective cohort study ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,digestive system diseases ,Stage III Colon Cancer ,colon cancer ,Oncology ,030220 oncology & carcinogenesis ,Prognostic model ,biology.protein ,T-stage ,business - Abstract
BackgroundThe prognostic stratification of colon cancer using only the tumor-node-metastasis (TNM) stage has some limitations. We sought to increase the accuracy of stratifying patients with stage III colon cancer by constructing a prognostic model combining carcinoembryonic antigen (CEA) with TNM.MethodsWe retrospectively analyzed the data generated from stage III colon cancer patients who had early postoperative CEA measurement from 21 to 100 days after surgery from 2006 to 2017. CEA value was processed using restricted cubic splines (RCS) method. The prognostic model was developed using cox proportional hazards regression.ResultsThe time later than 20 days after surgery was optimal for measuring CEA, which was determined by comparing the prognostic value for preoperative and postoperative CEA (N = 2,049), and by evaluating the relationship between the hazard ratio (HR) and postoperative CEA measuring time. Postoperative CEA, T stage and N stage were selected into the final model, and the mean integrated-AUC (iAUC) was 0.78 with 1,000 × bootstrap resampling, which was higher than the model using only T and N stages (TN model; mean iAUC, 0.66). The net reclassification improvement (NRI) was 15% when compared with TN model. Patients could be divided into high and low risk groups by the model, and 3-year disease-free survival (DFS) were 53.7% and 87.0%, respectively (HR, 4.30; 95% CI, 2.65 to 6.96; P < 0.001). Similar results were found in the validation set.ConclusionsStage III colon cancer could be stratified more accurately using the new prognostic model combining postoperative CEA with T and N stage.
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- 2020
33. DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer
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Ying Zhang, Chundong Zhang, Yunlong Lei, Longhao Li, and Yi Li
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Fibroblast Growth Factor 9 ,DJ-1 ,Epithelial-Mesenchymal Transition ,QH301-705.5 ,Colorectal cancer ,Science ,Protein Deglycase DJ-1 ,Vimentin ,Fibroblast growth factor ,General Biochemistry, Genetics and Molecular Biology ,FGF9 ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Cell Line, Tumor ,medicine ,Humans ,Epithelial–mesenchymal transition ,Biology (General) ,Wnt Signaling Pathway ,neoplasms ,030304 developmental biology ,0303 health sciences ,biology ,EMT ,Wnt signaling pathway ,Prognosis ,medicine.disease ,Immunohistochemistry ,digestive system diseases ,Gene Expression Regulation, Neoplastic ,stomatognathic diseases ,030220 oncology & carcinogenesis ,biology.protein ,Cancer research ,Colorectal Neoplasms ,General Agricultural and Biological Sciences ,Research Article - Abstract
Tumor metastasis is the main contributor to high recurrence and mortality in colorectal cancer (CRC). In a previous study, we found that DJ-1 plays an important role in CRC metastasis, and is the main target in Ciclopirox olamine (CPX)-treated CRC. However, the mechanism underlying DJ-1-induced CRC metastasis remains elusive. In the present study, our results showed that DJ-1 could activate Wnt signaling resulting in enhanced invasive potential and epithelial-to-mesenchymal transition (EMT) in CRC cells. RNA-seq and bioinformatics analysis reveals that the DJ-1/Wnt signaling pathway may promote CRC cells’ EMT by regulating fibroblast growth factor 9 (FGF9) expression. Molecular validation showed that expression of FGF9 was upregulated by the DJ-1/Wnt signaling pathway and decreasing FGF9-expression impeded DJ-1-induced CRC invasive ability and EMT, suggesting that FGF9 is involved in DJ-1-enhanced CRC metastasis. In addition, we show that FGF9 was overexpressed in CRC human specimens and was significantly associated with tumor differentiation. High FGF9 expression was correlated with worse overall survival, and a correlation exhibited between FGF9 and EMT markers (E-cadherin and Vimentin) in CRC samples. Together, our results determined that FGF9 was involved in DJ-1-induced invasion and EMT in CRC cells, and may represent a promising therapeutic candidate for CRC anti-metastatic strategies., Summary: DJ-1 could activate Wnt signaling to enhance FGF9 expression, resulting in enhanced invasive potential and epithelial-to-mesenchymal transition (EMT) in CRC cells. FGF9 predicts poor survival in patients with CRC.
- Published
- 2020
34. Fe–Co/alumina catalysts for production of high calorific synthetic natural gas: Effect of Fe/Co ratio
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Geunjae Kwak, Chundong Zhang, Jinmo Park, Seok Chang Kang, Ji-Yong Lee, Hyung-Sik Kim, and Ki-Won Jun
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Substitute natural gas ,X-ray absorption spectroscopy ,Materials science ,General Chemical Engineering ,Alloy ,02 engineering and technology ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,Carbide ,Catalysis ,Chemical engineering ,law ,engineering ,Calcination ,0210 nano-technology ,Dispersion (chemistry) ,Syngas - Abstract
The effect of the Fe/Co ratio on the catalytic performance of Fe–Co/alumina catalysts has been investigated in the production of high-calorific synthetic natural gas (SNG) from syngas. Fe–Co/alumina catalysts with different Fe/Co molar ratios were synthesized by the co-precipitation method and characterized using XRD, BET, H2-TPR, Raman, XAS, and XPS. At higher Fe/Co ratios (≥2), the calcined Fe–Co/alumina catalysts were mainly composed of α-Fe2O3 and CoFe2O4. The presence of Co improved the dispersion of iron oxides and the catalyst reducibility under H2 atmosphere. The Fe–Co/alumina catalysts partially formed FeCo alloys when they were reduced at 350 °C under H2. The formation of FeCo alloy destabilized the iron carbide phase and suppressed the carbon chain growth. These Fe–Co/alumina catalysts were efficient in producing high calorific SNG with a heating value of over 60 MJ/Nm3.
- Published
- 2018
35. Correlation between microcirculation and contrast-enhanced ultrasonography after crush injury of limbs
- Author
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Jie Tang, Xin Wang, and Chundong Zhang
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Male ,Contrast Media ,030218 nuclear medicine & medical imaging ,Microcirculation ,Crush Injuries ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Muscle, Skeletal ,Vein ,Ultrasonography ,business.industry ,Ultrasound ,Skeletal muscle ,General Medicine ,Blood flow ,Anatomy ,medicine.disease ,Hindlimb ,medicine.anatomical_structure ,Cuff ,Crush injury ,Female ,Rabbits ,business ,Blood Flow Velocity ,Artery - Abstract
To explore the microcirculation formation mechanism of contrast-enhanced (CE) ultrasonography imaging performance in rabbits with limb muscle crush injury. Seventy-two New Zealand white rabbits were randomly divided into two groups. A limb muscle crush injury model was created by airing a balloon cuff device with a force of 40 kpa. CE ultrasonography parameters were detected in the first group. In vivo microcirculation parameters were detected in the second group. Fine blood vessel diameter and blood flow velocity were calculated before extrusion and 0.5, 2, 6, 24 h, and 3 days after decompression. Compared with the uninjured muscle, reperfusion of the injured muscles showed early and high enhancement in CE ultrasonography images. The time-intensity curve showed a trend of rapid elevation and gradual drop. Compared with the control group, fine artery and vein diameters in the experimental group were wider and the blood flow velocity was slower, especially in the fine veins. In vivo microcirculation detection can reflect changes in muscle microvascular diameter and blood flow velocity, which have a correlation with quantitative ultrasound imaging parameters.
- Published
- 2017
36. Green liquid fuel and synthetic natural gas production via CO2 hydrogenation combined with reverse water-gas-shift and Co-based Fischer-Tropsch synthesis
- Author
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Ki-Won Jun, Hae-Gu Park, Guofeng Guan, Hui Wan, Chundong Zhang, Tian-Sheng Zhao, Seok Ki Kim, Ruxing Gao, and Lei Wang
- Subjects
Substitute natural gas ,Materials science ,business.industry ,Process Chemistry and Technology ,Fischer–Tropsch process ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Water-gas shift reaction ,0104 chemical sciences ,Liquid fuel ,Renewable energy ,Liquid hydrocarbons ,Chemical Engineering (miscellaneous) ,0210 nano-technology ,Process engineering ,business ,Waste Management and Disposal - Abstract
In recent years, significant attention has been paid to the CO2 mitigation via the power-to-liquids (PTL) and power-to-gas (PTG) processes because they can efficiently transform CO2 into high-value products such as liquid hydrocarbons and synthetic natural gas (SNG), and provide a promising solution for the storage of the intermittent renewable energy. Herein, we suggested a PTL process and a PTL/PTG process combined with the reverse-water-gas-shift (RWGS) and Co-based Fischer-Tropsch synthesis (FTS), which respectively produce liquid hydrocarbons only and the combination of liquid hydrocarbons and high-calorie SNG, based on the previous study regarding the PTL and PTL/PTG processes composed of Fe-based FTS. We conducted the process modelling and comparative techno-economic analysis to determine the key performance of the proposed PTL and PTL/PTG processes including the CO2 mitigation rate, energy efficiency, total product cost and CO2 mitigation cost. The proposed PTL and PTL/PTG processes can be regarded as feasible technical solutions to convert wasted CO2 into high-value liquid hydrocarbons and SNG. Additionally, the indirect PTL and PTL/PTG processes were helpful for improving the production of liquid hydrocarbons. Meanwhile, the direct PTL/PTG processes and indirect PTL processes favor the energy efficiency and CO2 mitigation.
- Published
- 2021
37. Transformation of CO2 into liquid fuels and synthetic natural gas using green hydrogen: A comparative analysis
- Author
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Hae-Gu Park, Ki-Won Jun, Seok Ki Kim, Chundong Zhang, Lei Wang, Ruxing Gao, Tian-Sheng Zhao, Hui Wan, and Guofeng Guan
- Subjects
Substitute natural gas ,Process modeling ,Hydrogen ,business.industry ,Process (engineering) ,020209 energy ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Renewable energy ,Fuel Technology ,Transformation (function) ,020401 chemical engineering ,chemistry ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,0204 chemical engineering ,Process engineering ,business ,Efficient energy use - Abstract
The power-to-liquids (P2L) and power-to-gas (P2G) processes which utilize renewable power to convert carbon dioxide and water into value-added syncrude and synthetic natural gas have recently gained much attention as an efficient way for CO2 mitigation. Based on our previously proposed direct P2L and P2L/P2G hybrid processes in the absence of the reverse-water–gas-shift unit, in this work, we developed the indirect P2L and P2L/P2G hybrid processes combined with the reverse-water–gas-shift unit, which produce solely syncrude and the combination of syncrude and synthetic natural gas, respectively. A comparative study of the indirect and direct P2L and P2L/P2G hybrid processes via the process modelling and techno-economic analysis was implemented to quantitatively evaluate their process performance differences, and it was indicated that the indirect P2L and P2L/P2G hybrid processes were also able to be considered as suitable technologies for the transformation of CO2 into high-value hydrocarbons, and the indirect P2L/P2G hybrid process seemed to be more competitive than the indirect P2L process from both technical and economic aspects. Moreover, compared to the direct P2L and P2L/P2G hybrid processes, the indirect P2L and P2L/P2G hybrid processes produce more syncrude, however, they are less efficient in aspects of energy efficiency and net CO2 reduction.
- Published
- 2021
38. DEPDC1 is required for cell cycle progression and motility in nasopharyngeal carcinoma
- Author
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Xuefei Feng, Yitao Wang, Youquan Bu, Lian Zhang, Hongxia Li, Yan Mi, Ling Zhu, Longxia He, Chundong Zhang, and Jiang Zhu
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Vimentin ,medicine.disease_cause ,03 medical and health sciences ,Cyclin D1 ,Downregulation and upregulation ,Medicine ,Mitosis ,DEPDC1 ,mitosis ,biology ,business.industry ,nasopharyngeal carcinoma ,Cell cycle ,medicine.disease ,030104 developmental biology ,Oncology ,Nasopharyngeal carcinoma ,Cancer research ,biology.protein ,cell cycle ,business ,Carcinogenesis ,Multipolar spindles ,Research Paper - Abstract
// Xuefei Feng 1, * , Chundong Zhang 2, * , Ling Zhu 1 , Lian Zhang 2 , Hongxia Li 1 , Longxia He 1 , Yan Mi 1 , Yitao Wang 2 , Jiang Zhu 1 and Youquan Bu 2 1 Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China 2 Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016, China * These authors have contributed equally to this work Correspondence to: Jiang Zhu, email: zhujiang163mail@163.com Youquan Bu, email: buyqcn@cqmu.edu.cn , buyqcn@aliyun.com Keywords: DEPDC1, cell cycle, mitosis, nasopharyngeal carcinoma Received: January 09, 2017 Accepted: June 02, 2017 Published: June 29, 2017 ABSTRACT DEP domain containing 1 (DEPDC1) is a newly identified cancer-related and cell cycle related gene and has been demonstrated as a novel therapeutic target for bladder cancer. However, the functional involvement and therapeutic potential of DEPDC1 in nasopharyngeal carcinoma (NPC) remains unclear. Our results showed that DEPDC1 was overexpressed at both mRNA and protein levels in NPC tissues compared with normal or non-tumor tissues. The siRNA-mediated DEPDC1 depletion resulted in significant inhibition of proliferation and delay in cell cycle progression in both NPC cell lines, CNE-1 and HNE-1. Detailed analysis with indirect immunofluorescence assays revealed that DEPDC1 depletion caused significant mitotic arrest accompanied with mitotic defects such as multipolar spindles and multiple nuclei followed by apoptotic cell death. Notably, DEPDC1 depletion also reduces migration and invasion ability in both cell lines. Consistent with its regulatory role in NF-κB pathway, knockdown of DEPDC1 caused significant upregulation of A20 and downregulation of mutiple NF-κB downstream target genes implicated in proliferation and tumorigenesis (c-Myc, BCL2, CCND1, CCNB1 and CCNB2), and metastasis (MMP2, MMP9, ICAM1, vimentin, Twist1). Moreover, in vivo study demonstrated that DEPDC1 knockdown also caused significant inhibition of tumor growth in the NPC xenograft nude mouse model. Taken together, our present study demonstrated that DEPDC1 is essentially required for the accelerated cell cycle progression and motility in NPC cells, and strongly suggested that DEPDC1 may serve as a novel therapeutic target in NPC.
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- 2017
39. Effect of Reaction Conditions on the Catalytic Dehydration of Methanol to Dimethyl Ether Over a K-modified HZSM-5 Catalyst
- Author
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Geunjae Kwak, Chundong Zhang, Sungtak Kim, Yong-Tae Kim, and Ki-Won Jun
- Subjects
Inorganic chemistry ,02 engineering and technology ,General Chemistry ,Coke ,Atmospheric temperature range ,010402 general chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,medicine ,Dimethyl ether ,Methanol ,Dehydration ,0210 nano-technology ,Water content ,Space velocity - Abstract
The effect of temperature, pressure, space velocity and feed-stream water content in the synthesis of dimethyl ether from methanol over a K-HZSM-5 catalyst was evaluated with respect to the activity, physicochemical properties and deactivation of the catalyst. Increasing the water content in the feed stream allowed to proceed the reaction over a wider temperature range. Despite a decrease in the methanol conversion at low temperatures (
- Published
- 2017
40. Carbon dioxide utilization in a gas-to-methanol process combined with CO 2 /Steam-mixed reforming: Techno-economic analysis
- Author
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Geunjae Kwak, Chundong Zhang, Ruxing Gao, Hae-Gu Park, and Ki-Won Jun
- Subjects
Carbon tax ,Discounted payback period ,020209 energy ,General Chemical Engineering ,Organic Chemistry ,Environmental engineering ,Energy Engineering and Power Technology ,Internal rate of return ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Investment (macroeconomics) ,Net present value ,Fuel Technology ,Greenhouse gas ,Economic evaluation ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,Profitability index ,0210 nano-technology - Abstract
Conceptual design for two options of carbon-dioxide-utilized gas-to-methanol process (CGTM) was implemented by using process simulation software Aspen Plus. The overall mass and energy stream results as well as the thermal and carbon efficiency were obtained from the developed process models. Before the following economic evaluation and sensitivity analysis, total capital investment (TCI) and total product cost (TPC) of both CGTM options were determined. Then, economic evaluation were conducted to assess the economic profitability of the base cases for both CGTM options, using the economic evaluation indicators such as net present value (NPV), internal rate of return (IRR), and discounted payback period (DPBP). Furthermore, sensitivity analysis as well as break-even analysis were also applied to investigate the economic performance of both CGTM options under different circumstances, by changing parameters such as methanol and NG prices, plant scale, and carbon tax. It was shown that the methanol price, CAPEX, and NG price are the most sensitive factors, and the two CGTM options were economically feasible in the plant scale range of 2500–5000 ton per day, according to the economic evaluation indicators NPV, IRR, and DPBP, and were more economically competitive in the case of higher plant scale and carbon tax.
- Published
- 2017
41. Redox Imbalance in the Development of Colorectal Cancer
- Author
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Youquan Bu, Qian Xu, Chundong Zhang, Xin Liu, Hao Liu, Yunlong Lei, and Huifang Zhu
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,Review ,Oxidative phosphorylation ,medicine.disease_cause ,Redox ,03 medical and health sciences ,chemistry.chemical_compound ,Internal medicine ,redox modification ,medicine ,oxidative stress ,chemistry.chemical_classification ,Reactive oxygen species ,medicine.disease ,CRC ,Crosstalk (biology) ,030104 developmental biology ,chemistry ,Biochemistry ,Second messenger system ,cysteine residues ,DNA ,Oxidative stress - Abstract
Redox imbalance is resulted from the destruction of balance between oxidants and antioxidants. The dominant oxidants are reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins. Generally speaking, low concentration of ROS is indispensable for cell survival and proliferation. However, high concentration of ROS is cytotoxic. Additionally, ROS are now known to induce the oxidative modification of macromolecules especially proteins. The redox modification of proteins is involved in numerous biological processes related to diseases including CRC. Herein, we attempt to afford an overview that highlights the crosstalk between redox imbalance and CRC.
- Published
- 2017
42. Efficient utilization of carbon dioxide in a gas-to-methanol process composed of CO2/steam–mixed reforming and methanol synthesis
- Author
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Geunjae Kwak, Chundong Zhang, Yun-Jo Lee, Hae-Gu Park, and Ki-Won Jun
- Subjects
Methanol reformer ,Chemistry ,Process Chemistry and Technology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Chemical engineering ,Greenhouse gas ,Carbon dioxide ,Chemical Engineering (miscellaneous) ,Organic chemistry ,Methanol ,Process simulation ,0210 nano-technology ,Waste Management and Disposal ,Efficient energy use ,Syngas - Abstract
Two process models for a carbon-dioxide-utilized gas-to-methanol (GTM) process (CGTM) that primarily produces methanol were developed using the process simulation software Aspen Plus. Both models comprised a reforming unit, a methanol synthesis unit and a recycling unit, with the feeding point of the fresh feed CO2 as the principal configurational difference. In the reforming unit, CO2/Steam–mixed reforming was performed to generate the targeted syngas in flexible compositions. Meanwhile, CO2 hydrogenation was conducted over a Cu-based catalysts in the methanol synthesis unit to directly produce the targeted product, methanol. After methanol synthesis, the unreacted syngas was recycled to the methanol synthesis and reforming units to enhance energy efficiency. The simulation results revealed that both CGTM options can favorably improve the energy efficiency and significantly reduce the total CO2 emissions, compared to a conventional GTM process. The energy efficiency was shown to be highly affected by the recycle ratio and a higher recycle ratio seemed to favorably improve CO2 conversion, enhance energy efficiency, and reduce CO2 emissions. However, the split ratio (recycle-to-reforming unit/total recycle) seems to have little effect on the energy efficiency, and the optimum recycle to the reforming unit was determined to be none.
- Published
- 2016
43. PRR14 overexpression promotes cell growth, epithelial to mesenchymal transition and metastasis of colon cancer via the AKT pathway
- Author
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Li-Juan Fu, Chundong Zhang, and Fangfang Li
- Subjects
0301 basic medicine ,Male ,Colorectal cancer ,Chromosomal Proteins, Non-Histone ,Cell ,Apoptosis ,medicine.disease_cause ,Biochemistry ,Metastasis ,Mice ,0302 clinical medicine ,Basic Cancer Research ,Medicine and Health Sciences ,Small interfering RNAs ,Cell Cycle and Cell Division ,Neoplasm Metastasis ,Multidisciplinary ,Tissue microarray ,Cell Death ,Cell Cycle ,Cell cycle ,Cancer Cell Migration ,Gene Expression Regulation, Neoplastic ,Nucleic acids ,Cell Motility ,medicine.anatomical_structure ,Oncology ,Cell Processes ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Medicine ,Female ,Signal Transduction ,Research Article ,Epithelial-Mesenchymal Transition ,Science ,Mice, Nude ,Cell Migration ,Biology ,03 medical and health sciences ,medicine ,Biomarkers, Tumor ,Genetics ,Animals ,Humans ,Epithelial–mesenchymal transition ,Non-coding RNA ,Cell Cycle Inhibitors ,PI3K/AKT/mTOR pathway ,Colorectal Cancer ,Biology and life sciences ,Cell growth ,Cancers and Neoplasms ,Cell Biology ,medicine.disease ,HCT116 Cells ,Gene regulation ,030104 developmental biology ,Cancer research ,RNA ,Gene expression ,Carcinogenesis ,Proto-Oncogene Proteins c-akt ,Developmental Biology - Abstract
BackgroundPRR14 (Proline rich protein 14) was firstly identified for its ability to specify and localize heterochromatin during cell cycle progression. Aberrant expression of PRR14 is associated with the tumorigenesis and progression of lung cancer. However, its involvement in colon cancer remains unknown. Herein, we report the role of PRR14 in colon cancer.MethodsColon cancer tissue microarray was used to analyze and compare the expression of PRR14 among some clinicopathological characteristics of colon cancer. HCT116 and RKO cells were transfected with siRNA to downregulate PRR14 expression. The roles of PRR14 in proliferation, migration and invasion of the cell lines were determined using cell counting kit-8, colony formation assay, wound healing assay and transwell assays respectively. The expression of PRR14 was measured by using immunofluorescence, qRT- PCR and western blot.ResultsPRR14 was highly expressed in colon cancer tissues, and the expression level was correlated with tumor size, distant metastasis and Tumor Node Metastasis stages. Functional study revealed that downregulation of PRR14 inhibited colon cancer cells growth, migration and invasion. Furthermore, knockdown of PRR14 inhibited epithelial-mesenchymal transition (EMT) process, cell cycle-associated proteins expression and p-AKT level.ConclusionPRR14 may promote the progression and metastasis of colon cancer, and may be a novel prognostic and therapeutic marker for the disease.
- Published
- 2019
44. Thermodynamic analysis of chemical looping coupling process for coproducing syngas and hydrogen with in situ CO2 utilization
- Author
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Yanyan Zhu, Qian Yang, Chundong Zhang, Xiaoxun Ma, Xue Xia, Leiyu Zhang, Xiaodong Wang, Ming Yan, and Binran Zhao
- Subjects
Materials science ,Hydrogen ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Combustion ,Oxygen ,Fuel Technology ,020401 chemical engineering ,Nuclear Energy and Engineering ,chemistry ,Chemical engineering ,Heat exchanger ,0202 electrical engineering, electronic engineering, information engineering ,Exergy efficiency ,0204 chemical engineering ,Chemical looping combustion ,Syngas ,Hydrogen production - Abstract
This study proposed a novel chemical looping coupling system for coproducing syngas and hydrogen with in situ CO2 utilization. It integrates chemical looping combustion, chemical looping reforming, CO2-H2O co-splitting, hydrogen production and air oxidation using CH4 as fuel and iron oxide as oxygen carrier. In this process, syngas and H2 purification, in addition to CO2 capture and storage are no longer necessary. It not only produces high-purity hydrogen and syngas without pollutants and greenhouse gas emissions, but realizes the sufficient utilization of feed and oxygen carriers. A detailed thermodynamic analysis of the proposed chemical looping coupling process was conducted by Aspen Plus. The effects of key parameters, such as feed ratio, temperature, and pressure in each reactor on the process performance were investigated in terms of the utilization of CH4, the yield and purity of syngas and hydrogen, and the oxygen carrier coupling. In addition, the energy balance was analyzed for the coupling system with heat exchanger network. Based on the established process model, we concluded that the preferable feed ratios in combustion, reforming, co-splitting, steam and air reactors were 4, 1, 0.4, 1.1 and 1.5, respectively. The preferable temperatures in the five reactors mentioned above were 900, 900, 850, 500 and 500 °C in sequence, and the preferable pressure was 1 atm in each reactor. Under these conditions, high-purity hydrogen (100%) and syngas (99% and 93% purity) with ideal H2/CO ratio (~2) could be obtained. The energy efficiency and exergy efficiency of this coupling system reached up to 90.54% and 72.04%, respectively.
- Published
- 2021
45. HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
- Author
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Dandan Xu, Lian Zhang, Ying Zhang, Deqian Qiao, Yitao Wang, Yiyun Sun, Youquan Bu, and Chundong Zhang
- Subjects
0301 basic medicine ,Lung Neoplasms ,Chromosomal Proteins, Non-Histone ,Pyridines ,Cell ,Datasets as Topic ,Kaplan-Meier Estimate ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Gene expression ,lung squamous cell carcinoma ,RNA-Seq ,RNA, Small Interfering ,Lung ,Genetics (clinical) ,biology ,SKA2 ,Nuclear Proteins ,Prognosis ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,Gene Knockdown Techniques ,030220 oncology & carcinogenesis ,PRR11 ,Signal Transduction ,Transcriptional Activation ,lcsh:QH426-470 ,hedgehog ,BUB1 ,Zinc Finger Protein Gli2 ,Zinc Finger Protein GLI1 ,Article ,03 medical and health sciences ,GLI1 ,Cell Line, Tumor ,Genetics ,medicine ,Humans ,Hedgehog Proteins ,Gene ,Hedgehog ,Proteins ,lcsh:Genetics ,Pyrimidines ,030104 developmental biology ,biology.protein ,Cancer research ,Ectopic expression ,GLI - Abstract
We previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter. This gene pair synergistically promoted the development of non-small cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remains obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from The Cancer Genome Atlas (TCGA) database using the correlation analysis of gene expression and gene set enrichment analysis (GSEA), which revealed that the PRR11-SKA2 correlated gene list highly resembled the Hedgehog (Hh) pathway activation-related gene set. Subsequently, GLI1/2 inhibitor GANT-61 or GLI1/2-siRNA inhibited the Hh pathway of LSCC cells, concomitantly decreasing the expression levels of PRR11 and SKA2. Furthermore, the mRNA expression profile of LSCC cells treated with GANT-61 was detected using RNA sequencing, displaying 397 differentially expressed genes (203 upregulated genes and 194 downregulated genes). Out of them, one gene set, including BIRC5, NCAPG, CCNB2, and BUB1, was involved in cell division and interacted with both PRR11 and SKA2. These genes were verified as the downregulated genes via RT-PCR and their high expression significantly correlated with the shorter overall survival of LSCC patients. Taken together, our results indicate that GLI1/2 mediates the expression of the PRR11-SKA2-centric gene set that serves as an unfavorable prognostic indicator for LSCC patients, potentializing new combinatorial diagnostic and therapeutic strategies in LSCC.
- Published
- 2021
46. Sustainable production of methanol using landfill gas via carbon dioxide reforming and hydrogenation: Process development and techno-economic analysis
- Author
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Geunjae Kwak, Chundong Zhang, Ki-Won Jun, Guofeng Guan, Ruxing Gao, Seok Ki Kim, Yun-Jo Lee, and Hae-Gu Park
- Subjects
Present value ,Waste management ,Discounted payback period ,Carbon dioxide reforming ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Strategy and Management ,05 social sciences ,Internal rate of return ,02 engineering and technology ,Industrial and Manufacturing Engineering ,Landfill gas ,Conceptual design ,050501 criminology ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,0505 law ,General Environmental Science ,Efficient energy use ,Syngas - Abstract
Aiming at achieving the large-scale CO2-equivalent reduction in the landfill industry, conceptual design of two sustainable landfill gas-to-methanol process options without the pre-treatment and methanol upgrading sections were implemented via using Aspen Plus simulator. In both proposed options, the optimum syngas ratio (H2/(2CO + 3CO2) = 1) is fulfilled by either supplying additional H2 (option 1) or pre-separating the surplus CO2 in LFG using membrane (option 2). A comparative techno-economic analysis was carried out to determine the energy efficiency and the CO2-equivalent reduction rate, as well as the net present value (NPV), the internal rate of return (IRR), and the discounted payback period (DPBP) of both proposed options. It is shown that both options 1 and 2 can be regarded as alternative processes for converting landfill gas to methanol, and option 1 is more energy efficient and eco-friendly, while, option 2 is more economically competitive. Moreover, a sensitivity analysis indicates that the CAPEX, the prices of methanol, CO2 allowance, and H2 are the most sensitive factors, and option 1 can be economically comparable with option 2 given that the H2 price can be lowered down to around 1000 $/Mt. This work provides two candidate process routes for efficient conversion of landfill gas to value-added methanol, which makes the landfill industry become more sustainable and profitable, especially in the event of a future high carbon tax and low H2 price.
- Published
- 2020
47. Efficient utilization of associated natural gas in a modular gas-to-liquids process: Technical and economic analysis
- Author
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Geunjae Kwak, Chundong Zhang, Seok Chang Kang, Ruxing Gao, and Ki-Won Jun
- Subjects
business.industry ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology ,02 engineering and technology ,Syngas to gasoline plus ,Modular design ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Steam reforming ,Gas to liquids ,Fuel Technology ,Natural gas ,Greenhouse gas ,Environmental science ,0210 nano-technology ,Process engineering ,business ,Syngas ,Efficient energy use - Abstract
Two process models for modular gas-to-liquids (GTL) process mainly producing Fischer–Tropsch (F–T) synthetic oils were developed by Aspen Plus software. Both models mainly comprised a reforming unit, an F–T synthesis unit, and a recycle unit, with the syngas generation and syngas ratio conditioning methods as the main difference. In the reforming unit, either steam reforming or CO 2 /Steam-mixed reforming was selected to generate the desired syngas. Co-based microchannel F–T synthesis was applied to convert the obtained syngas to synthetic oils. After F–T synthesis, a portion of the unreacted syngas was recycled to improve energy efficiency, and reduce CO 2 emissions. Technical and economic analyses were both employed to investigate the two modular GTL options. For the technical aspect, effects of recycling and splitting ratios on the performance of both options were investigated. Sensitivity analysis and break-even analysis were applied to the economic analysis. It was found that the increased energy efficiency and reduced CO 2 emissions could be achieved by recycling a portion of the unreacted syngas. Both options were economically viable at the plant scale of 2500 BPD, and were more competitive in the event of high carbon tax.
- Published
- 2016
48. Techno-economic evaluation of methanol production using by-product gases from iron and steel works
- Author
-
Seok Chang Kang, Geunjae Kwak, Chundong Zhang, Guofeng Guan, Yun-Jo Lee, and Ruxing Gao
- Subjects
Carbon tax ,Renewable Energy, Sustainability and the Environment ,business.industry ,020209 energy ,Energy Engineering and Power Technology ,02 engineering and technology ,Investment (macroeconomics) ,Fuel Technology ,020401 chemical engineering ,Nuclear Energy and Engineering ,Conceptual design ,Work (electrical) ,0202 electrical engineering, electronic engineering, information engineering ,By-product ,Environmental science ,Production (economics) ,Profitability index ,0204 chemical engineering ,Process engineering ,business ,Efficient energy use - Abstract
Aiming at achieving large-scale CO2 mitigation in the iron & steel industries via efficient utilization of the by-product gases such as the coke oven gas (COG) and Linz-Donawitz converter gas (LDG) in the iron & steel works, conceptual design of a LDG-to-methanol process (option 1) and two LDG/COG-to-methanol processes (options 2 and 3 without or with H2 purification, respectively) was implemented using the process simulator Aspen Plus. Both the process development and economic analysis for all the three proposed options were conducted to determine the technical performance via indicators such as the energy efficiency and CO2 reduction rate, and the profitability via indicators such as the total capital investment and the net methanol production cost. Meanwhile, six case studies under different recycle ratios (0.5–0.95) were conducted for each proposed option to investigate the effects of recycle ratio on the technical and economic performance. The techno-economic analysis results clearly show that all the three proposed options are highly efficient for CO2 mitigation via methanol production using the by-product gases LDG and COG. More specifically, options 1 and 3 seem to be more energy efficient and eco-friendly than option 2, in terms of energy efficiency and CO2 reduction rate. Whereas, options 2 and 3 seem to be more economically feasible than option 1, considering the net methanol production cost. From the aspects of both technical and economic performance, option 3 is considered as the most competitive process. This work provides candidate process routes for the iron & steel industries to become more sustainable and profitable, especially in the event of a high carbon tax and a low H2 price in the future.
- Published
- 2020
49. Correction: Identification of active sites for CO2 hydrogenation in Fe catalysts by first-principles microkinetic modelling
- Author
-
Seung Ju Han, Sun-Mi Hwang, Hae-Gu Park, Chundong Zhang, Ki-Won Jun, and Seok Ki Kim
- Subjects
Renewable Energy, Sustainability and the Environment ,General Materials Science ,General Chemistry - Abstract
Correction for ‘Identification of active sites for CO2 hydrogenation in Fe catalysts by first-principles microkinetic modelling’ by Seung Ju Han et al., J. Mater. Chem. A, 2020, 8, 13014–13023, DOI: 10.1039/D0TA01634A.
- Published
- 2020
50. DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis
- Author
-
Hao Liu, Lian Zhang, Kui Wang, Xin Liu, Chundong Zhang, Youquan Bu, Jing Zhou, Qing He, Quanmei Chen, Yi Li, Yitao Wang, Yunlong Lei, Lu Zhang, and Ying Zhang
- Subjects
Male ,0301 basic medicine ,Cancer Research ,Colorectal cancer ,Protein Deglycase DJ-1 ,Bone Morphogenetic Protein 4 ,Metastasis ,Mice ,0302 clinical medicine ,Cell Movement ,Medicine ,Wnt Signaling Pathway ,beta Catenin ,Regulation of gene expression ,lcsh:Cytology ,Wnt signaling pathway ,RNA-Binding Proteins ,Cell migration ,DNA-Binding Proteins ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,Colorectal Neoplasms ,Signal Transduction ,Immunology ,Mice, Nude ,Article ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Cyclin D1 ,Cell Line, Tumor ,Adjuvant therapy ,Animals ,Humans ,lcsh:QH573-671 ,neoplasms ,Aged ,Cell Proliferation ,Cell growth ,business.industry ,Cell Biology ,HCT116 Cells ,medicine.disease ,Xenograft Model Antitumor Assays ,digestive system diseases ,030104 developmental biology ,Cancer research ,business ,Transcription Factors - Abstract
Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as a potential metastasis biomarker of CRC. In this study, we found that DJ-1 was upregulated in CRC. The levels of DJ-1 were closely correlated with the depths of invasion and predicted patient outcome. Enforced expression of DJ-1 could enhance CRC proliferation and metastasis in vitro and in vivo by stimulating Wnt-β-catenin signaling. Specifically, DJ-1-induced β-catenin nuclear translocation stimulated TCF transcription activity, which promoted BMP4 expression for CRC cell migration and invasion, and elevated CCND1 expression for CRC cell proliferation, respectively. Furthermore, DJ-1-induced Wnt signaling activation was dependent on PLAGL2 expression. In conclusion, our study demonstrates that DJ-1 can promote CRC metastasis by activating PLAGL2–Wnt–BMP4 axis, suggesting novel therapeutic opportunities for postoperative adjuvant therapy in CRC patients.
- Published
- 2018
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