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Falls in older adulthood can have serious consequences. It is therefore important to identify ways to prevent falls, particularly from the voice of older adults. Bottom-up qualitative exploration of the perspectives of older adults can provide rich insights that can help inform the development of effective fall prevention programmes. However, currently there is a dearth of such empirical data, especially among urban-dwelling older adults in high-density cities where fall rates are high. The current study aimed to examine qualitatively perceptions of neighbourhood physical environment in relation to falls, perceived risks and fear of falling, and strategies and behaviours for fall prevention in a sample of urban-dwelling older adults in the high-density city of Hong Kong. Face-to-face semi-structured in-depth interviews were conducted with 50 community-dwelling older adults. Interviews were transcribed verbatim and analysed using thematic analysis techniques. Five general themes were revealed: risks and circumstances of falls, consequences of falls, fear of falling and its consequences, neighbourhood environment, and strategies and behaviours of fall prevention. While older adults discussed the risks of falling and held a fear of falling, these beliefs were mixed. In addition to fall prevention strategies (e.g. keep balance), current findings highlighted the importance of establishing protective factors (e.g. flat and even walking paths) and reducing risk factors (e.g. neighbourhood clutter) in neighbourhood environments. For urban-dwelling older adults in high-density cities, current findings highlight the importance of focusing efforts at the built environment level in addition to strategies and behaviours of fall prevention at the individual level.

This longitudinal study applied the integrated model of self-determination theory (SDT) and the theory of planned behaviour (TPB) to explain COVID-19 preventive behaviours among parents of young children in the United States.The study adopted a two-wave longitudinal study design. Parents (The parameter estimates of the model (CFI.96, TLI.86, RMSEA = .05, SRMR = .03) fit acceptably well to the data. Psychological need support was positively and significantly linked to autonomous and controlled motivation and amotivation. Autonomous motivation was positively and significantly correlated with TPB factors, and intention. Intention was a significant and positive predictor of behavioural adherence.The integrated model of SDT and the TPB appeared to be applicable to the explanation of COVID-19 prevention among the U.S. parents. Longitudinal data showed that a psychological need supportive social environment was related to favourable motivation, social cognition beliefs, intention and behavioural adherence to the preventive behaviours of parents protecting their young children from COVID-19.

Strong seedlings are essential for high yield. To explore the foundation of strong seedlings, we investigated various factors influencing the conversion and distribution of seed storage reserves during seedling establishment in maize inbred lines. Three maize inbred lines were used to explore the effects of seed size, seed vigor, illumination duration, temperature, water content, and salt concentration of the seedling medium on the utilization of seed storage reserves during seedling establishment. The results showed that the conversion rate of small seeds was 3.69 to 17.71% higher than that of large seeds. Moreover, prolonged illumination time was conducive to the formation of strong seedlings. However, low temperature, drought stress and salt stress reduced the conversion rate of seed storage reserves and increased the root/shoot ratio. These results could be used to guide field management during seedling emergence and develop improved germplasm with a high conversion rate of seed storage reserves.

The aging Chinese population is growing fast, and the proportion of the population aged 60 years old is projected to reach 28% by 2040, estimated 402 million. With increased life expectancy, the aging population tends to suffer from health risks and diseases, which create a burden on public health policy. Hence, it is essential to promote healthy and active aging, which includes improving older adults' physical and mental capacities and advocating for the achievement of a healthy life expectancy. Despite the rapidly growing aging population in China, there have been no reviews investigating the effect of physical activity on physical and mental health among older Chinese adults. Therefore, the current study aimed to review studies from the past 15 years that illustrate the effect of physical activity on physical and mental health among Chinese older adults. Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews (PRISMA-ScR), this review addresses the associations between physical activity, physical health and mental health among older Chinese adults. A total of 371 studies were included in the scoping review, which covered the relationships between physical activity, physical health and mental health variables. The scoping review also revealed the impact of various kinds of physical activity affecting older adults' physical health, such as functional fitness, body composition, fall risk and balance, and mental health issues, such as depression, anxiety, cognitive function and quality of life. Moreover, studies have identified innovative forms of physical activity as emerging trends in physical activity interventions for older adults. To conclude, this scoping review captured the common effects between physical activity and overall wellbeing, including physical, mental, and cognitive health. Additionally, diverse forms of physical activity intervention, such as group-based and supervised individual interventions, should be supported, and cross-cultural exercise comparisons should be made in future explorations.

Background Diagnostic criteria for sarcopenia have not been established in Chinese. This study established criteria based on the L3‐skeletal muscle index (L3‐SMI) and assessed its value for outcomes predicting in cirrhotic Chinese patients. Methods Totally 911 subjects who underwent a CT scan at two centres were enrolled in Cohort 1 (394 male and 417 female subjects, aged 20–80 years). The data of those subjects younger than 60 years (365 male and 296 female subjects) were used to determine the reference intervals of the L3‐SMI and its influencing factors. Cohort 2 consisted of 480 patients (286 male and 184 female patients) from three centres, and their data were used to investigate the prevalence of sarcopenia and evaluate the value of L3‐SMI for predicting the prognosis and complications of cirrhosis. Results Age and sex had the greatest effects on the L3‐SMI (P 14 (RR = 4.310, 95% CI 2.091–8.882, P

Wu-wei is an important construct but is rarely discussed in the sport psychology literature. The present discussion fills the gap in literature and provides a conceptual overview of the wu-wei alternative. After explaining wu-wei briefly, the current state of mindfulness research is discussed to highlight the lack of research in understanding wu-wei and non-striving in sport psychology. In addition, the links between wu-wei and relevant constructs including mindfulness, non-striving, flow, nonduality, Zen, Mushin, motivation, goals, and implicit learning were clarified. Furthermore, suggestions on incorporating wu-wei as part of mindfulness training for athletes and possible future research directions are provided. In this difficult time of the global pandemic, wu-wei or non-striving mindset can help supporting athletes’ well-being and pursuit of goals beyond winning and striving.

Introduction: We aimed to determine the diagnostic criteria of myosteatosis in a Chinese populationand investigate the effect of skeletal muscle abnormalities on the outcomes of cirrhotic patients. Methods: Totally 911 volunteers were recruited to determine the diagnostic criteria and impact factors of myosteatosis, and 480 cirrhotic patients were enrolled to verify the value of muscle alterations for prognosis prediction and establishnew noninvasive prognostic strategies. Results: Multivariate analysis showed age, sex, weight, waist circumference and biceps circumference had remarkable influence on the L3 skeletal muscle density (L3-SMD). Based on the cut-off of a mean−1.28×SD among adults aged＜60 years, the diagnostic criteria for myosteatosis wasL3-SMD＜38.93 Hu in malesand L3-SMD＜32.82 Hu in females. Myosteatosis rather than sarcopenia has close correlation with portal hypertension. The concurrence of sarcopenia and myosteatosis not only is associated with poor liver function, but also evidently reduced the overall and liver transplantation-free survival of the cirrhotic patients (PCI, 0.800-0.949) for 6-month survival, 0.831 (95% CI, 0.764-0.898) for 1-year survival and 0.813 (95% CI, 0.756-0.871) for 2-year survival prediction, respectively. Conclusions: This study provides evidence of the significant correlation between skeletal muscle alterations andpoor outcomes of cirrhosis, and establishes valid and convenient nomograms incorporating musculoskeletal disorders for the prognostic prediction of liver cirrhosis. Further large-scale prospective studies are necessary to verify the value of the nomograms.

Based on the social ecological approach, a photovoice study was conducted to explore how neighborhood built and social environments facilitate or hinder college students’ lifestyle behaviors, including physical activity, active transportation, and dietary behavior. A total of 37 college students took photos about neighborhood built and social environments that may affect their physical activity, dietary behavior, and active transportation, and shared their perceptions about how neighborhood built and social environments influence their lifestyle behaviors. Our findings demonstrated that the availability and accessibility of services, school facilities, and home facilities affected physical activity and dietary behaviors among college students. Moreover, the well-developed transportation facilities and networks benefit college students’ active transportation. Environments-based interventions are recommended in future research to better understand the associations between neighborhood built and social environments and lifestyle behaviors in college students.

Objective: Poor sleep quality resulting from experiencing anxiety, and low adherence to sleep hygiene behaviours, may lead to poorer academic engagement. The aim of the current study was to elucidate the associations between anxiety, sleep hygiene, sleep quality, and academic engagement of university students. Methods: Participants (N = 614) comprised students attending a major university in Australia (n = 329) and Hong Kong (n = 285). A two-wave correlational design was utilised. At Time 1 (T1), anxiety was measured using the anxiety subscale of the Depression Anxiety Stress Scale 21 (DASS-21) and sleep hygiene behaviour was assessed with the Sleep Hygiene Index (SHI). One month later, at Time (T2), sleep quality was measured with the self-report Pittsburgh Sleep Quality Index (PSQI) global sleep quality score and academic engagement was measured using the shortened Utrecht Work Engagement Scale–Student version (UWES-S). Structural equation modelling was used to analyse the associations among study constructs. Results: Analyses found that in both the Australia and Hong Kong samples the model showed good fit to data for the observed effect sizes. In both samples, anxiety predicted sleep quality and effects were mediated by sleep hygiene. Also, the indirect effect of anxiety on academic engagement via sleep hygiene and sleep quality was significant, and fully mediated the effects of anxiety on academic engagement in both samples. Conclusions: Results indicate that students with higher anxiety tend to have lower adherence to sleep hygiene behaviours and experience poorer sleep quality which, in turn, negatively affects their academic engagement. Key Points What is already known about this topic: (1) Students are expected to spend large amounts of time studying and display a high level of engagement with their academic programme. (2) Academic engagement is linked to students’ academic achievement and wellness. (3) Academic disengagement has been linked to poor sleep hygiene behaviours and high levels of anxiety. What this topic adds: (1) The impact of anxiety on sleep quality was associated with sleep hygiene behaviours, and the impact of anxiety on academic engagement was associated with sleep hygiene behaviours and sleep quality. (2) The model predicting academic engagement from anxiety mediated by sleep hygiene and sleep quality was similar in both Australian and Hong Kong students. (3) Findings may signpost possible avenues for the development of interventions aimed at improving university students’ sleep quality and academic engagement.

Background Research indicates that perceived behavioral control (PBC) is an important determinant of behavior and that it is composed of perceived capability and opportunity. However, typical measurement of these constructs may be confounded with motivation and outcome expectations. Vignettes presented before questionnaire items may clarify construct meaning leading to precise measurement. Purpose The purpose of this study was to develop and validate measures of perceived capability and opportunity that parse these constructs from the influence of motivation and outcome expectations using vignettes. Methods Study 1 collected feedback from experts (N = 9) about the initial measure. Study 2a explored internal consistency reliability and construct and discriminant validity of the revised measure using two independent samples (N = 683 and N = 727). Finally, using a prospective design, Study 2b (N = 1,410) investigated test–retest reliability, construct and discriminant validity at Time 2, and nomological validity. Results After Study 1, the revised measure was tested in Studies 2a and 2b. Overall, the evidence suggests that the measure is optimal with four items for perceived capability and three for the perceived opportunity. The measure demonstrated strong internal consistency ( > 0.90) and test–retest reliability (intraclass correlation coefficients [ICCs] > .78). The measure also showed construct and discriminant validity by differentiating itself from behavioral intentions (i.e., motivation) and affective attitude (based on expected outcomes) (SRMR = 0.03; RMSEA = 0.06). It also demonstrated evidence of nomological validity as behavior 2 weeks later was predicted. Conclusions We recommend researchers use this tool in future correlational and intervention studies to parse motivation and outcome expectations from perceived capability and opportunity measurement.

The claustrum has been hypothesized to participate in high-order brain functions, but experimental studies to demonstrate these functions are currently lacking. Neural activity recording of the claustrum in freely-behaving animals allows for correlating claustral activities with specific behaviors. However, previously utilized methods for studying the claustrum make it difficult to monitor neural activity patterns of freely-behaving animals in real time. Here we applied fiber photometry to monitor Ca

The current study aimed to examine the mediation effects of experiential acceptance, cognitive defusion, decentering, and nonattachment on the paths from mindfulness to athlete burnout, subjective well-being, and flourishing among elite athletes. Chinese elite athletes (n = 515; 225 females) were recruited from three provincial sports centers representing 22 sports. The athletes completed self-reported measures of mindfulness, experiential acceptance, cognitive defusion, decentering, and nonattachment, athlete burnout, subjective well-being, and flourishing. Path analyses were conducted to test the mediation effects from mindfulness to athlete burnout, subjective well-being, and flourishing. Path analyses revealed that the effect from mindfulness to athlete burnout was mediated by experiential acceptance, cognitive defusion, and nonattachment, but not decentering. The effect from mindfulness to subjective well-being was mediated by decentering, cognitive defusion, and nonattachment, but not experiential acceptance. The effect from mindfulness to flourishing was mediated by decentering and nonattachment, but not experiential acceptance and cognitive defusion. Findings from this study provided empirical support for the changing mechanisms regarding how mindfulness leads to adaptive and maladaptive outcomes, which can inform future mindfulness-based interventions for elite athletes.

In this paper, we described our recent thinking on the mental health assessment methods of Chinese elite athletes and introduced a contextually appropriate sport training centre-based mental health...

Le but de cette etude etait de tester le modele de processus parallele etendu (EPPM) dans le contexte du nouveau coronavirus (COVID-19) parmi un echantillon representatif de Canadiens Les intentions de suivre les recommandations du gouvernement, la distanciation physique et les reactions de controle de la peur (c -a-d les reactions negatives et defensives) ont ete predites a laide de l' EPPM (menace et efficacite percues) et de variables demographiques (âge, sexe et education) Les donnees ont ete recueillies a l'aide d'une enquete transversale en ligne realisee par une societe tierce d'etude de marche L'echantillon etaIt compose de 1 055 adultes (Âge median = 48,82, E -T - 16,66;51,2 % de femmes) Une regression multiple par variable dependante (c -a-d , les intentions de suivre les recommandations du gouvernement, la distanciation physique et les reactions de controle de la peur) a ete effectuee Certaines interactions bidirectionnelles et tridirectionnelles ont egalement ete incluses dans les modeles Les adultes plus âges, les femmes et les individus les plus instruits avaient generalement des intentions plus elevees, respectaient davantage la distanciation physique et affichaient des scores plus faibles au niveau des reactions de controle de la peur En outre, conformement a l'EPPM, le modele global suggerait que les personnes affichant des scores eleves pour la menace et l'efficacite percues avaient le profil le plus positif (intentions elevees, plus grand respect de la distanciation physique et reactions de controle de la peur moindres) L'efficacite percue etait un facteur predictif particulierement fort dans les analyses Nous recommandons que les interventions en sante publique ciblent les hommes, les jeunes et les moins instruits En outre, il est recommande que les interventions augmentent a la fois la menace et l'efficacite percues (en particulier l'efficacite) Bien que la conception etait transversale, il etait necessaire d'accelerer l'etude a un moment ou elle est cruellement necessaire Les recherches futures devraient confirmer nos conclusions en utilisant des modeles experimentaux Alternate abstract:The purpose of this study was to test the extended parallel process model (EPPM) in the context of the novel coronavirus disease (COVID-19) among a nationally representative sample of Canadians Intentions to follow government recommendations, physical distancing, and fear control responses (i e , negative and defensive reactions) were predicted using EPPM (perceived threat and efficacy) and demographic variables (age, gender, and education) Data were collected using a cross-sectional online survey through a third-party market research company The sample was composed of 1,055 adults (M age = 48 82, SD = 16 66;51 2% female) One multiple regression per dependent variable (i e , intentions to follow government recommendation, physical distancing, and fear control responses) was conducted Certain two-way and three-way interactions were also included in the models Older adults, females, and more educated individuals generally had higher intentions, engaged in more physical distancing, and had lower scores for fear control responses Also, consistent with the EPPM the overall paltem suggested that people with high scores for both perceived threat and efficacy had the most positive profile (high intentions and physical distancing and low fear control) Perceived efficacy was a particularly strong predictor in analyses We recommend that public health interventions target males, younger people, and those who are less educated Furthermore, it is recommended that interventions increase both perceived threat and efficacy (especially efficacy) Although the design was cross-sectional, it was necessary to expedite the study in a time when it is sorely needed Future research should confirm our findings using experimental designs

Epilepsy is a highly prevalent and drug-refractory neurological disorder characterized by spontaneous recurrent seizures. Estrogen is identified to be proconvulsant and lowers the seizure threshold of female epilepsy. Estrogen receptor β (ERβ) has been proposed to mediate neuroprotection in epilepsy, although the underlying mechanism remains unknown. Rationale: In this study, we investigated the role of ERβ in the epileptogenesis of female temporal lobe epilepsy (TLE). Methods: Immunohistochemistry, immunofluorescence, western blots, Golgi staining, 1H MRS and whole-cell patch-clamp were used to evaluate ERβ expression, pathological changes, and synaptic excitation /inhibition (E/I) balance in female TLE patients and ovariectomized (OVX) chronic epileptic mice. Electroencephalogram (EEG) recordings were recorded to evaluate the epileptic susceptibility in OVX WT and ERβ-/- mice. And high-throughput RNA-sequence was performed to identify differential expression genes (DEGs) which can elucidate the potential mechanism of ERβ regulating the seizure susceptibility. Results: ERβ expression was decreased in the brains of female TLE patients and OVX chronic epileptic mice. ERβ deletion enhanced seizure susceptibility and exacerbated the imbalance of synaptic E/I in hippocampal CA1 area of OVX epileptic mice. In line with these observations, RNA-sequence data further identified glutamine ligase (GLUL) as the target of ERβ involved in regulating synaptic E/I in CA1. Furthermore, ERβ agonist WAY-200070 markedly suppressed epileptic phenotypes and normalized GLUL expression in CA1 region of kainic acid (KA) induced OVX chronic epileptic model. Conclusions: Our data provide novel insight into the pathogenesis of female TLE, and indicate ERβ provides a new therapeutic strategy for female TLE patients.

This study aimed to examine the relationships between occupational stressors, mental health problems, and sleep difficulty, and the mediating roles of cognitive fusion and cognitive reappraisal on the relationships in Chinese nurses. A total of 323 nurses (mean age = 32.11 ± 6.75 years) from 25 hospitals in China participated a cross-sectional online survey. Participants were asked to refer to the period during the severest time of the COVID-19 pandemic in China (January to March 2020) when assessing the psychological variables. The direct links from occupational stressors to cognitive fusion, cognitive reappraisal, mental health and sleep difficulty were significant. Cognitive fusion and cognitive reappraisal mediated the links from occupational stressors to mental health problems, while cognitive fusion and mental health problems mediated the links from occupational stressors to sleep difficulty. The sequential mediation via cognitive fusion and mental health problems as well as via cognitive reappraisal and mental health problems on the links from occupational stressors to sleep difficulty were also significant. Findings from the current study indicate that intervention strategies focusing on the reduction of cognitive fusion and improvement of cognitive reappraisal could help better prepare nurses to alleviate mental health problems and sleep difficulties that are related to COVID-19 and potentially similar pandemics in the future.

Lymphocyte antigen 6 family member D (LY6D) was enhanced specifically in senescent cells, while its effects on pyroptosis, a programmed cell death, remains unknown. The goal of this study was to assess the role of LY6D in the mediation of pyroptosis during nonalcoholic steatohepatitis (NASH). After screening out LY6D as a specific liver fibrosis-associated gene using the GSE55747 dataset from the GEO database, we established a NASH mouse model using methionine and choline deficient-diet feeding and an in vitro model using lipopolysaccharide (LPS)-treated hepatocytes. LY6D was overexpressed in NASH livers as well as in LPS-treated hepatocytes. Silencing of LY6D inhibited NASH-associated hepatocyte pyroptosis. With the aid of bioinformatics analysis, promoter-luciferase reporter and ChIP-qPCR assays, we identified FOSL2 as an upstream transcription factor of LY6D. FOSL2, which was highly expressed in NASH, promoted LY6D transcription by binding to the promoter of LY6D. Depletion of FOSL2 significantly inhibited NASH-associated hepatocyte pyroptosis, which was significantly reversed after overexpression of LY6D. Moreover, the promotion of hepatocyte pyroptosis by the FOSL2/LY6D axis was significantly attenuated by specific inhibition of NLRP3. These findings suggesting that FOSL2/LY6D axis may be a key molecular axis and a potential target for NASH therapeutics.

The current study evaluated the construct validity, internal consistency reliability, discriminant, and concurrent validities, along with the measurement invariance of the Brief Self-Control Scale ...

Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder characterized by hamartomas in multiple organ systems. The TSC1 and TSC2 genes have been identified as the genetic basis of TSC. Two gene tests were used for definitive genetic diagnosis. In our study, the case of a Chinese pediatric patient with seizures, hypomelanotic macules, hyperpigmented patches, multiple parenchymal lesions in the ventricle, and developmental retardation is detailed. Whole-genome sequencing (WGS) and multiplex ligation-dependent probe amplification (MLPA) were employed to detect genetic variations and copy number variations of TSC1 and TSC2. A novel heterozygous nonsense mutation in the TSC2 gene (c.3751A>T, p.Lys1251Ter) was identified in a Chinese pediatric patient suffering from TSC, whose unaffected parents did not carry this mutation. The mutation was classified as “pathogenic” according to the American College of Medical Genetics (ACMG) guidelines. WGS was carried out to definitively diagnose and detect variations in the exon and noncoding region of the gene and copy number variations in the whole genome simultaneously. For diseases with complex genetic mechanisms, WGS as the first-line test can be efficient and cost-effective for clinical diagnosis.

Aim Nod-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation has emerged as a contributor to epileptogenesis. Endoplasmic reticulum stress (ERS) plays an important role in epilepsy-induced neurodegeneration. NLRP3 activation and ERS reactions share the same induction factors, suggesting that these processes may be interdependent. However, the correlation between NLRP3 and ERS in TLE has not been confirmed. Methods The expression patterns of NLRP3 inflammasome and ERS-related markers in the temporal neocortices of TLE patients were investigated by western blotting, immunohistochemistry and immunofluorescent labelling. Correlations between the protein levels of NLRP3 and the expression of ERS-related markers were assessed using Spearman's rank correlation test. To observe the relationship between the NLRP3 inflammasome and ERS, inhibitors were used in a status epilepticus (SE) model. Results Our results show that NLRP3 inflammasome components and ERS-related markers were upregulated in the temporal neocortices of TLE patients, and were mainly localized to neurons, astrocytes and microglia. We found a positive correlation between the protein levels of NLRP3 and the expression of ERS-related markers in the temporal neocortices of 20 TLE patients. Furthermore, after blocking the NLRP3 inflammasome with MCC950, the expression of ERS-related markers was markedly decreased in the hippocampi of SE mice. Moreover, TUDCA, a specific ERS inhibitor, also reduced the expression of NLRP3 components in the hippocampus under SE conditions. Conclusion Taken together, our data reveal the interdependence of the NLRP3 inflammasome and ERS in the epileptogenic zone of TLE patients and in the hippocampi of mice in the early post-SE phase.

Sleep hygiene behaviors in undergraduate students are associated with night-time sleep duration and quality, daytime sleepiness, and psychological distress. This study aimed to identify the social psychological factors that impact on university students’ sleep hygiene behaviors in samples from two countries. Participants were undergraduate students from Australia (N = 201, MAge = 22.82, SDAge = 8.89; 165 female) and Hong Kong (N = 161, MAge = 20.47, SDAge = 7.80; 84 female). The study used a correlational-prospective design. Individuals self-reported their intention, attitude, subjective norms, perceived behavioral control, and past behavior with respect to sleep hygiene behaviors. Four weeks later, the students self-reported their action plans and participation in sleep hygiene behaviors. Analysis indicated acceptable model fit to data for both the Australian and Hong Kong samples. Results showed significant direct effects of attitude, subjective norms, perceived behavioral control, and past behavior on intention, and significant direct effects of action planning and past behavior on prospectively measured sleep hygiene behavior. There were also significant indirect effects of attitude, subjective norms (Hong Kong sample only), and perceived behavioral control on behavior mediated by intention and action planning. Overall, the model predicted a large portion of the variance in sleep hygiene behavior for both the Australian (R2 = .524) and Hong Kong (R2 = .483) samples. Schenker and Gentleman t tests found no parameters significantly differed between samples. Results indicate that university students’ sleep hygiene behaviors are a function of both motivational and volitional processes. This formative data can inform future interventions to improve the sleep hygiene practices of university students.

BACKGROUND The treatment outcome of transarterial chemoembolization (TACE) in unresectable hepatocellular carcinoma (HCC) varies greatly due to the clinical heterogeneity of the patients. Therefore, several prognostic systems have been proposed for risk stratification and candidate identification for first TACE and repeated TACE (re-TACE). AIM To investigate the correlations between prognostic systems and radiological response, compare the predictive abilities, and integrate them in sequence for outcome prediction. METHODS This nationwide multicenter retrospective cohort consisted of 1107 unresectable HCC patients in 15 Chinese tertiary hospitals from January 2010 to May 2016. The Hepatoma Arterial-embolization Prognostic (HAP) score system and its modified versions (mHAP, mHAP2 and mHAP3), as well as the six-and-twelve criteria were compared in terms of their correlations with radiological response and overall survival (OS) prediction for first TACE. The same analyses were conducted in 912 patients receiving re-TACE to evaluate the ART (assessment for re-treatment with TACE) and ABCR (alpha-fetoprotein, Barcelona Clinic Liver Cancer, Child-Pugh and Response) systems for post re-TACE survival (PRTS). RESULTS All the prognostic systems were correlated with radiological response achieved by first TACE, and the six-and-twelve criteria exhibited the highest correlation (Spearman R = 0.39, P = 0.026) and consistency (Kappa = 0.14, P = 0.019), with optimal performance by area under the receiver operating characteristic curve of 0.71 [95% confidence interval (CI): 0.68-0.74]. With regard to the prediction of OS, the mHAP3 system identified patients with a favorable outcome with the highest concordance (C)-index of 0.60 (95%CI: 0.57-0.62) and the best area under the receiver operating characteristic curve at any time point during follow-up; whereas, PRTS was well-predicted by the ABCR system with a C-index of 0.61 (95%CI: 0.59-0.63), rather than ART. Finally, combining the mHAP3 and ABCR systems identified candidates suitable for TACE with an improved median PRTS of 36.6 mo, compared with non-candidates with a median PRTS of 20.0 mo (log-rank test P < 0.001). CONCLUSION Radiological response to TACE is closely associated with tumor burden, but superior prognostic prediction could be achieved with the combination of mHAP3 and ABCR in patients with unresectable liver-confined HCC.

Emergence of dysmorphic neurons is the primary pathology in focal cortical dysplasia (FCD) associated pediatric intractable epilepsy; however, the etiologies related to the development and function of dysmorphic neurons are not fully understood. Our previous studies revealed that the expression of vascular endothelial growth factor-C (VEGF-C) and corresponding receptors VEGFR-2, VEGFR-3 was increased in the epileptic lesions of patients with tuberous sclerosis complex or mesial temporal lobe epilepsy. Here, we showed that the expression of VEGF-C, VEGFR-2, and VEGFR-3 was increased at both mRNA and protein levels in patients with cortical lesions of type I, IIa, and IIb FCD. The immunoreactivity of VEGF-C, VEGFR-2 and VEGFR-3 was located in the micro-columnar neurons in FCD type I lesions, dysplastic neurons (DNs) in FCD type IIa lesions, balloon cells (BCs) and astrocytes in FCD type IIb lesions. Additionally, the amplitude of evoked-EPSCs (eEPSC) mediated by NMDA receptor, the ratio of NMDA receptor- and AMPA receptor-mediated eEPSC were increased in the dysmorphic neurons of FCD rats established by prenatal X-ray radiation. Furthermore, NMDA receptor mediated current in dysmorphic neurons was further potentiated by exogenous administration of VEGF-C, however, could be antagonized by ki8751, the blocker of VEGFR-2. These results suggest that VEGF-C system participate in the pathogenesis of cortical lesions in patients with FCD in association with modulating NMDA receptor-mediated currents.

Background Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults, with pathological mechanisms remaining to be fully elucidated. Fibroblast Growth Factor 13 (FGF13) encodes an intracellular protein involved in microtubule stabilization and regulation of voltage-gated sodium channels (VGSCs) function. FGF13 mutation has been identified in patients with inherent seizure, suggesting a potential association between FGF13 and the etiology of TLE. Here, we set to explore the pathological role of FGF13 in the etiology of TLE. Results We found that the expression of FGF13 was increased in the cortical lesions and CA1 region of sclerotic hippocampus and correlated with the seizure frequency in TLE patients. Also, Fgf13 expression was increased in the hippocampus of chronic TLE mice generated by kainic acid (KA) injection. Furthermore, Fgf13 knockdown or overexpression was respectively found to attenuate or potentiate the effects of KA on axonal length, somatic area and the VGSCs-mediated current in the hippocampal neurons. Conclusions Taken together, these findings suggest that FGF13 is involved in the pathogenesis of TLE by modulating microtubule activity and neuronal excitability.

Nutrition labels on food packages are designed to assist consumers in making healthy decisions. Based on the model of a dual-process system, the current study examined how people might be affected by nutrition labels and consuming contexts when making choices about healthy foods. Using four types of nutrition labels (i.e., the NuVal label, 5-Color nutrition label, traffic light label, and daily value label), participants were instructed to choose the healthier foods with or without time constraints in two experiments. In Experiment 1, participants were presented with pairs of foods accompanied by the same type of nutrition labels to measure the efficiency of their health evaluation. In Experiment 2, two types of labels with inconsistent nutritional information were presented to participants simultaneously to measure their preference regarding the nutrition labels. Findings of the current study support the notion that the traffic light label is advantageous in terms of both the efficiency of, and preferences regarding, nutrition judgment, especially with time constraints. When there was only one type of nutrition label, participants made decisions fastest and most accurately when observing the NuVal label, regardless of time constraints. Overall, the reliable interactions between the time constraints and patterns of nutrition labels have theoretical implications for the appeal-based heuristics and rational-based processing when making health-related food decisions.

Traditionally, mental training in sport and performance realms has mainly been based on the psychological skills training (PST) procedures which include assumptions of changing, replacing, and elim...

Temporal lobe epilepsy (TLE) is defined as the sporadic occurrence of spontaneous recurrent seizures, and its pathogenesis is complex. SHP‐2 (Src homology 2‐containing protein tyrosine phosphatase 2) is a widely expressed cytosolic tyrosine phosphatase protein that participates in the regulation of inflammation, angiogenesis, gliosis, neurogenesis and apoptosis, suggesting a potential role of SHP‐2 in TLE. Therefore, we investigated the expression patterns of SHP‐2 in the epileptogenic brain tissue of intractable TLE patients and the various effects of treatment with the SHP‐2‐specific inhibitor SHP099 on a pilocarpine model. Western blotting and immunohistochemistry results confirmed that SHP‐2 expression was upregulated in the temporal neocortex of patients with TLE. Double‐labeling experiments revealed that SHP‐2 was highly expressed in neurons, astrocytes, microglia and vascular endothelial cells in the epileptic foci of TLE patients. In the pilocarpine‐induced C57BL/6 mouse model, SHP‐2 upregulation in the hippocampus began one day after status epilepticus, reached a peak at 21 days and then maintained a significantly high level until day 60. Similarly, we found a remarkable increase in SHP‐2 expression at 1, 7, 21 and 60 days post‐SE in the temporal neocortex. In addition, we also showed that SHP099 increased reactive gliosis, the release of IL‐1β, neuronal apoptosis and neuronal loss, while reduced neurogenesis and albumin leakage. Taken together, the increased expression of SHP‐2 in the epileptic zone may be involved in the process of TLE.

Objective Transport-related cycling can contribute to employees’ increased physical activities in their daily lives, with potential health and environmental benefits. Still, a theoretical understanding of the links between the perceptions of physical environment and transport-related cycling through social cognitive theories is unclear. In addition, there is a lack of understanding on the moderating effects of the perceived physical environment on social cognitive pathways when predicting transport-related cycling. The purpose of this study was to apply the theory of planned behavior (TPB) framework to determine (a) whether TPB mediates the effects between the perceived physical environment and transport-related cycling and (b) whether the perceived physical environment moderates TPB-cycling relations. Methods Using a prospective design, Chinese employees (N = 193) self-reported their perceived physical environment of their workplace neighborhood (i.e., residential density, land-use diversity, land-use accessibility, street connectivity, infrastructures, aesthetics, traffic-related safety, and crime-related safety), attitudes, subjective norm, perceived behavior control (PBC), intention, and duration and frequency of transport-related cycling in the last week. One month later, self-reported cycling for transport was again collected from a subset sample of employees (N = 98). Mediation and moderation structural equation models linking perceived physical environment, TPB constructs, and transport-related cycling were tested. Results The effects from residential density to attitudes and subjective norm, from land-use diversity and street connectivity to subjective norm and PBC, and from aesthetics and crime-related safety to attitudes, were found significant and positive. Attitudes, subjective norm, and PBC predicted intention, in which intention further predicted employee’s future transport-related cycling one month later. Importantly, attitudes, subjective norm, and PBC mediated the relations from land-use diversity and street connectivity to intention, while intention mediated the effect from PBC to employee’s future transport-related cycling. Past behavior showed significant effects on attitudes, subjective norm, PBC, intention, and employee’s future transport-related cycling. The effect from past behavior to intention was mediated by the social cognitive variables of attitudes, subjective norm, and PBC. However, no moderating effects of perceived physical environments on the TPB-cycling relations were found, except the moderating effect of crime-related safety on the path from PBC to cycling. Conclusion Current results indicate that Chinese employees’ transport-related cycling are a function of environmental (i.e., perceived physical environmental attributes) and social cognitive (i.e., attitudes, subjective norm, perceived behavioral control, and intention) factors. Findings of the current study can inform the development of multi-component behavioral change interventions targeting the improvement of transport-related cycling for employees.

Over the last decade, mindfulness and acceptance-based approaches to mental training have been widely applied in the field of sport psychology. In order to develop a context-sensitive mindfulness a...

"Introduction: Resilience, which is defined as the process of adapting well in the face of adversity, trauma, tragedy, threats or significant sources of stress, is important for older adults to maintain a healthy life. This qualitative study aimed to identify the characteristics that contribute to resilience among a group of community-dwelling older adults in Hong Kong. Methods: Individual and focus group interviews were conducted to collect information on life adverse events, attitudes towards adversity, and beliefs underlying the approaches to overcoming adversity among 25 Chinese older adults (2M and 23F) aged 69 to 100 years old (M=80.00, SD=39.08). The transcripts were analyzed using qualitative content analysis. Results: Seven characteristics were emerged under the three factors, including equanimity, positive attitudes towards life, meaningfulness, and self-reliance (internal factor), social support and environmental support (external factor), and spirituality and faith (existential factor). Conclusion: In addition to identifying the seven characteristics that contribute to resilience, this study also identified “taking part in physical activity” as an individual resource contributing to resilience. The study also found “government support” is an important environmental factor contributing to positive adaptation to stressful life of the elderly in Hong Kong. The results and findings may facilitate the development of interventions on enhancing older adults’ resilience."

Cortical tubers in patients with tuberous sclerosis complex (TSC) are highly associated with intractable epilepsy. Recent evidence suggests a close relationship between FGF13 and seizures. To understand the role of FGF13 in the pathogenesis of cortical tubers, we investigated the expression pattern of FGF13 in cortical tubers of TSC compared with normal control cortices (CTX). We found that both the mRNA and protein levels of FGF13 were significantly higher in the cortical tubers from patients with TSC than in the control cortices. The immunohistochemical results showed strong FGF13 immunoreactivity in abnormal cells, including dysplastic neurons (DNs) and giant cells (GCs). Moreover, double-label immunofluorescence analyses confirmed that FGF13 was mainly localized in neurons and nearly absent in glia-like cells. The protein levels of FGF13 in the TSC samples were positively correlated with the frequency of seizures before surgery. Taken together, these results suggest that the overexpression and distribution pattern of FGF13 may be related to intractable epilepsy caused by TSC.

Focal cortical dysplasias (FCDs) are well recognized as important causes of medically intractable epilepsy in both children and adults. To explore the potential role of fibroblast growth factor 13 (FGF13) in intractable epilepsy caused by FCDs, we examined the expression of FGF13 in cortical lesions from 23 patients with FCD type Ia (FCDIa), 24 patients with FCD type IIa (FCDIIa), and 12 patients with FCD type IIb (FCDIIb), and we compared the results with the FGF13 expression levels in control cortex (CTX) brain tissues from 12 nonepileptic normal subjects. Both the mRNA levels and protein levels of FGF13 were significantly higher in the cortical lesions from patients with FCD than in the control cortices. The immunohistochemical results showed that strong FGF13 immunoreactivity was observed in misshapen cells, including neuronal microcolumns, hypertrophic neurons, dysmorphic neurons, and most balloon cells. Moreover, double-label immunofluorescence analyses confirmed that FGF13 was mainly localized in neurons and nearly absent in glia-like cells. Taken together, our results suggest that the overexpression of FGF13 in FCDs and the cell-specific distribution patterns of FGF13 in misshapen neurons in FCDs could potentially contribute to intractable epilepsy caused by FCDs.

Prolonged stress is associated with poor physical and mental health outcomes. Understanding the mediators between personality and stress is critical for developing effective stress management interventions during a pandemic. Our study explored whether perceptions of threat from COVID-19 and efficacy to follow government recommendations for preventing COVID-19 would mediate the relationships between personality traits (e.g., neuroticism, conscientiousness-goal-striving, extroversion-activity and sociability) and perceived stress. In an online survey of a representative sample of Canadian adults (n = 1055), we found that higher neuroticism and extroversion were associated with higher levels of stress during the pandemic and a greater increase in stress levels compared to levels before the pandemic. Perceived threat and efficacy significantly mediated the relationship between neuroticism and stress, which suggested that individuals with higher neuroticism experienced higher levels of stress due to higher levels of perceived threat and lower levels of efficacy. Perceived threat did not mediate the relationship between extroverts and stress, which suggested that the source of stress may stem from elsewhere (e.g., inability to socialize). Our findings highlighted that personality traits could be an important factor in identifying stress-prone individuals during a pandemic and that stress management interventions need to be personality specific.

Professional doctor qualification certificate is widely used in domestic and even worldwide industry entry threshold. In 2013, the National Conference on Medical qualification examination put forward a new idea of phased examination, replacing the previous examination mode. In 2018, a number of colleges and universities have participated in empirical research. A total of 894 medical students in a medical college were studied. Through empirical analysis and research, the phased examination model can further consolidate the theoretical knowledge of medical students and improve clinical skills. On the basis of empirical research, this paper puts forward some suggestions and strategies for improving teaching, so as to improve the qualified rate of phased examination and introduce more advantages for the society. The doctor of the show.

Idiopathic generalized epilepsy(IGE) patients have genetic causes and their seizure onset mechanisms particularly during sleep remain elusive. Here we proposed that sleep-like slow-wave oscillations(0.5 Hz SWOs) potentiated excitatory or inhibitory synaptic currents in layer V cortical pyramidal neurons from wild-type(wt) mouse ex vivo brain slices. In contrast, SWOs potentiated excitatory, not inhibitory, currents in cortical neurons from heterozygous(het) knock-in(KI) IGE mice(GABAA receptor γ2 subunit Gabrg2Q390X mutation), creating an imbalance between evoked excitatory and inhibitory currents to effectively prompt neuronal action potentials. Similarly, more physiologically similar up/down-state(present during slow-wave sleep) induction in cortical neurons could potentiate excitatory synaptic currents within slices from wt/het Gabrg2Q390X KI mice. Consequently, SWOs or up/down-state induction in vivo (using optogenetic method) could trigger epileptic spike-wave discharges(SWDs) in het Gabrg2Q390X KI mice. To our knowledge, this is the first operative mechanism to explain why epileptic SWDs preferentially happen during non-REM sleep or quiet-wakefulness in human IGE patients.

The deep revolutionary development of 3D printing technology has brought unprecedented opportunities and challenges to the manufacturing industry. By comparing the changes of the present production methods and the old ones and combining the advantages and characters of 3D printing technology, this paper analyzes the knowledge system that is supposed to be mastered and interprets the dilemma and countermeasures to the talent training plan of the high-tech 3D printing in colleges and universities through the combination of the theory and the practice. It is hoping this paper may put forward feasible ideas for the training of 3D printing talents in colleges and universities. The training of high-tech talents not only determines the level of the industry, but also is the main position struggled by the manufacturing industry for the right to speak. 3D printing with its outstanding professional and practical characteristics combines the features of industrial design and art design and integrates plastic arts, industrial technology as well as appearance art. Under the new format, the manufacturing industry urgently needs the support of 3D printing technology to solve the problem of quantitative production and refinement. Therefore, the bridge link function of high technical skill type talented persons plays a crucial role.

Sleep hygiene behaviors in undergraduate students are associated with night-time sleep duration and quality, daytime sleepiness, and psychological distress. This study aimed to identify the social psychological factors that impact on university students' sleep hygiene behaviors in samples from two countries.Participants were undergraduate students from Australia (N = 201, MAnalysis indicated acceptable model fit to data for both the Australian and Hong Kong samples. Results showed significant direct effects of attitude, subjective norms, perceived behavioral control, and past behavior on intention, and significant direct effects of action planning and past behavior on prospectively measured sleep hygiene behavior. There were also significant indirect effects of attitude, subjective norms (Hong Kong sample only), and perceived behavioral control on behavior mediated by intention and action planning. Overall, the model predicted a large portion of the variance in sleep hygiene behavior for both the Australian (RResults indicate that university students' sleep hygiene behaviors are a function of both motivational and volitional processes. This formative data can inform future interventions to improve the sleep hygiene practices of university students.

Background Socioecological models highlight the potential direct and indirect effects of multiple levels of influence in explaining physical activity (PA). Social cognitive theories, however, position individual cognitions as the mediator of external factors such as the built environment when explaining PA. Purpose To appraise the evidence for direct and indirect associations between the built environment and social cognition to predict PA. Methods Literature searches were concluded in February 2019 using five common databases. Eligible studies were in the English language that included any direct and indirect tests of individual perceptions and the built environment with PA. Results The initial search yielded 18,521 hits, which was reduced to 46 independent studies of primarily medium quality after screening for eligibility criteria. Findings were grouped by type of PA then grouped by the type of individual and built environment constructs within the model, and subdivided by adult and youth samples. There was evidence that self-efficacy/perceived control accounted for the covariance between environmental accessibility/convenience and total PA, while habit accounted for the covariance in this relationship for transport PA, particularly in adult samples. There was no evidence that the built environment had a direct association with PA after controlling for individual-level factors. Conclusions The results provide initial support for the mediation tenet in social cognition models for the relationship between individual, built environment, and PA. In practice, these findings highlight the need for coordinated interventions of individual and environmental change.

Objectives The goal of the current study was to investigate the universality of the five-factor model of mindfulness and the measurement equivalence of the Five-Facet Mindfulness Questionnaire (FFMQ). Methods The study used FFMQdata from published and unpublished research conducted in 16 countries (total N = 8541). Using CFA, different models, proposed in the literature, were fitted. To test the cross- cultural equivalence of the best fitting model, a multi-group confirmatory factor analysis was used. Further, the equivalence of individual facets of the FFMQ and potential sources of non- equivalence was explored. Results The best fitting models in most samples were a five-facet model with a higher-order mindfulness factor and uncorrelated positive and negative item-wording factors and a five-facet model with a correlated facets and uncorrelated positive and negative item-wording factors. These models showed structural equivalence, but did not show metric equivalence (equivalent factor loadings) across cultures. Given this lack of equivalent factor loadings, not even correlations or mean patterns can be compared across cultures. A similar pattern was observed when testing the equivalence of the individual facets ; all individual facets failed even tests of metric equivalence. A sample size weighted exploratory factor analysis across cultures indicated that a six-factor solution might provide the best fit across cultures with acting with awareness split into two factors. Finally, both the five- and sixfactor solution showed substantially better fit in more individualistic and less tight cultures. Conclusions Overall, the FFMQ has conceptual and measurement problems in a cross-cultural context, raising questions about the validity of the current conceptualization of mindfulness across cultures. The results showed that the fit of the FFMQ was substantially better in individualistic cultures that indicate that further data from non-Western cultures is needed to develop a universal conceptualization and measurement of mindfulness.