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Increased expression of fibroblast growth factor 13 in cortical lesions of the focal cortical dysplasia
- Source :
- Brain research bulletin. 168
- Publication Year :
- 2020
-
Abstract
- Focal cortical dysplasias (FCDs) are well recognized as important causes of medically intractable epilepsy in both children and adults. To explore the potential role of fibroblast growth factor 13 (FGF13) in intractable epilepsy caused by FCDs, we examined the expression of FGF13 in cortical lesions from 23 patients with FCD type Ia (FCDIa), 24 patients with FCD type IIa (FCDIIa), and 12 patients with FCD type IIb (FCDIIb), and we compared the results with the FGF13 expression levels in control cortex (CTX) brain tissues from 12 nonepileptic normal subjects. Both the mRNA levels and protein levels of FGF13 were significantly higher in the cortical lesions from patients with FCD than in the control cortices. The immunohistochemical results showed that strong FGF13 immunoreactivity was observed in misshapen cells, including neuronal microcolumns, hypertrophic neurons, dysmorphic neurons, and most balloon cells. Moreover, double-label immunofluorescence analyses confirmed that FGF13 was mainly localized in neurons and nearly absent in glia-like cells. Taken together, our results suggest that the overexpression of FGF13 in FCDs and the cell-specific distribution patterns of FGF13 in misshapen neurons in FCDs could potentially contribute to intractable epilepsy caused by FCDs.
- Subjects :
- 0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Medically intractable epilepsy
Intractable epilepsy
Fibroblast growth factor
Immunofluorescence
03 medical and health sciences
Young Adult
0302 clinical medicine
Cortex (anatomy)
medicine
Humans
Child
Cerebral Cortex
Epilepsy
medicine.diagnostic_test
business.industry
General Neuroscience
Infant
Cortical dysplasia
medicine.disease
Fibroblast Growth Factors
030104 developmental biology
medicine.anatomical_structure
Mrna level
Child, Preschool
Malformations of Cortical Development, Group I
Immunohistochemistry
Female
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18732747
- Volume :
- 168
- Database :
- OpenAIRE
- Journal :
- Brain research bulletin
- Accession number :
- edsair.doi.dedup.....e44b55cbfcb8d628cd60088e4e704263