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2. Investigation of Aerodynamic Support Interference for Testing a Semispan T Tail Aircraft Model

Author

Mahmoud Mamou and Cabot A. Broughton

Subjects
Aerospace Engineering
Abstract

High-fidelity computational fluid dynamics (CFD) flow simulations were carried out to assess the sources of aerodynamic support interference of an aircraft half-model with a T-tail empennage mounted in a wind tunnel in an attempt to improve how well a semispan model can represent the corresponding full-span aircraft. The Bombardier research aircraft configuration (BRAC) model was used, which consists of a fuselage, a fuselage to wing fairing, a cruise wing with flap fairings, an engine nacelle and pylon, a vertical tail, and a horizontal stabilizer (HSTAB). The standard half-model support used at the National Research Council of Canada’s 1.5 m trisonic wind tunnel consists of a wall-mounted splitter plate to remove a sizable portion of the upstream tunnel wall boundary layer and a two-dimensional peniche sandwiched between the model symmetry plane and the splitter plate. CFD simulations of the BRAC model mounted in the wind tunnel were performed using the Menter shear stress transport turbulence model at a Mach number of 0.2. The CFD results for the standard (baseline) mounting arrangement compared favorably well with the half-model experimental data. The BRAC CFD model was then modified to provide reference “full-span” data and to examine several alternate model mounting arrangements. All simulations were compared with the ideal full-span reference simulations. Significant disturbances were found to be induced by the reflection plane boundary layer and primary horseshoe vortex on the flowfield surrounding the HSTAB, which had a direct impact on the measured overall model forces and moments.

Published
2023
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5. Dealing with Belief Uncertainty in Domain Models

Author

Lola Burgueño, Paula Muñoz, Robert Clarisó, Jordi Cabot, Sébastien Gérard, and Antonio Vallecillo

Subjects
Software
Abstract

There are numerous domains in which information systems need to deal with uncertain information. These uncertainties may originate from different reasons such as vagueness, imprecision, incompleteness, or inconsistencies, and in many cases, they cannot be neglected. In this article, we are interested in representing and processing uncertain information in domain models, considering the stakeholders’ beliefs (opinions). We show how to associate beliefs to model elements and how to propagate and operate with their associated uncertainty so that domain experts can individually reason about their models enriched with their personal opinions. In addition, we address the challenge of combining the opinions of different domain experts on the same model elements, with the goal to come up with informed collective decisions. We provide different strategies and a methodology to optimally merge individual opinions.

Published
2023
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7. Association of Time of Day With Outcomes Among Patients Triaged for a Suspected Severe Stroke in Nonurban Catalonia

Author

Álvaro García-Tornel, Alan Flores, Mikel Terceño, Pedro Cardona, Sergi Amaro, Meritxell Gomis, Josep Zaragoza, Jerzy Krupinski, Manuel Gómez-Choco, Natalia Mas, Dolores Cocho, Esther Catena, Francesc Purroy, Matias Deck, Marta Rubiera, Jorge Pagola, David Rodriguez-Luna, Jesús Juega, Noelia Rodríguez-Villatoro, Carlos A. Molina, Cristina Soro, Xavier Jimenez, Mercè Salvat-Plana, Antoni Dávalos, Tudor G Jovin, Sonia Abilleira, Natalia Pérez de la Ossa, Marc Ribó, Estela Sanjuan, Katherine Santana, Olga Maisterra, Estevo Santamarina, Marian Muchada, Sandra Boned, Antonio Palasi Franco, Marta Olivé Gadea, Matías Deck, Manuel Requena, Victoria Sala, Lucía Muñoz, Mónica Millán, Elena López-Cancio, Laura Dorado, María Hernández-Pérez, Jordi Ciurans, Daniela Samaniego, Tamara Canento, Lorena Martin, Anna Planas, Joaquin Broto, Agustín Sorrentino, Martí Paré, Nuole Zhu, Alicia Garrido, Laia Grau, Ane Miren Crespo, Silvia Presas, Miriam Almendrote, Alba Ramos, Giuseppe Lucente, Lourdes Ispierto, Manuel Lozano, Juan Luis Becerra, Marta Jiménez, Dolores Vilas Rolán, Nicolas Guanyabens, Josep Sanchez-Ojanguren, Alicia Martínez-Piñeiro, Sara Forcén, Mireia Gea, Marta Álvarez, Anna Ramos, Manuel Domínguez Lizarbe, Rubio Guerra, Irene Bragado, Andrea Arbex, Luis Rodríguez, Alejandro Bustamante, Pere Cardona Portela, Helena Quesada García, Blanca Lara Rodríguez, Nuria Cayuela, Julia Miró, Clara Marzal, Andrés Paipa, Sergio Campoy, Ana Núñez, Pablo Arroyo, Sarah Besora, Vanessa Adell, Jaume Campdelacreu, Montse Alemany Martí, Belén González, Laura Bau Vila, Marta Fiter Crespo, Anna Berbel, Ma. Cristina Villaescusa Urbaneja, Núria Guillen, Nuria Vidal, Patricia Valentina Vérez Santamaria, Diego Herrero Navarro, Marta Simó, Mercedes Falip, Elisabeth Matas, Neus Mongay Ochoa, Ariadna Gifreu, Albert Muñoz, Lucía Romero, Eduard Portell, Guillermo Hernández Perez, F. Ruiz Esteve, Silvia Teixidor, Augusto Salazar Talavera, Roser Gómez, Xabier Urra Nuin, Martha Vargas, Ángel Chamorro, Laura Llull, Arturo Renú, Salvatore Rudilosso, Raquel Sánchez del Valle, Helena Ariño, Nuria Solà, Delón la Puma, Francisco Gil, Juan Bernardo Gómez, Nuria Matos, Neus Falgàs, Sergi Borrego, Almudena Sánchez, Mircea Balasa, Carmen Montejo, Mar Guasp, David Reyes, Pablo Sánchez Cervilla, Jose Miguel Contador, Victor Augusto Vera Monge, Oscar Ramos, Alejandro Rodríguez, Ana Rodríguez Campello, Gemma Romeral Ballester, Mireia Llop Trujillano, Eva Giralt Steinhauer, Elisa Cuadrado Godia, Angel Javier Ois Santiago, Jordi Jimenez Conde, Joan Martí Fábregas, Daniel Guisado, Luís Prats, Pol Camps, Raquel Delgado, Alejandro Martínez Domeño, Rebeca Marín, David Cànovas, Jordi Estela, Marta Ros, Sonsoles Aranceta, Jordi Espinosa, Marta Rubio, Cristina Lafuente, Oriol Barrachina, Alicia Anguita, Anna Reverter, Carmen García, Gemma Sansa, Mariona Hervas, Monica Crosas, Tania Delgado, Dra Sonia Huertas Folch, Gemma Muñoz Gamito, Josep Trenado Alvarez, Teresa Subirana, Jessica Molina, Laura Comes Romero, Gemma Guardia Valls, Miriam Jover, Javier Joaquín Sotova, Sonia Mª García Sánchez, Sebastian Valenzuela, Juan José Mengual, M. Àngels Font, Mª Isabel Gómez Ruiz, Irati Zubizarreta, Susana Fernández González, Laura Gubieras, Carmen E. Cobos, Luis Mena Romo, Nuria Caballol, Luis Cano, Joaquín Serena Leal, Yolanda Silva Blas, Irene Bragado Trigo, Saima Bashir Viturro, Laura Pardo Albiñana, Montserrat Reina Garrido, Carla Marco Cazcarra, Karol Enrique Uscamaita, Fabian Márquez, Cristina Coll, Mar Irida Lloret Villlas, Berta Solano Vila, Berta Alemany Perna, Daniel López Domínguezl, Mercedes de Lera, Anna Cots Foraster, Urszula Bojaryn, Ikram Benabdelhak, Gerard Mauri Capdevila, Jordi Sanahuja Montesinos, Daniel Vázquez, José Vicente Hervás, Cristina González, Alejandro Quílez, Mikel Vicente Pascual, María Ruiz, Yolanda Riba, M. Pilar Gil Villar, Cristina García, Xavier Ustrell Roig, Mònica Baldrich Mora, Anna Pellisé Guinjoan, Judit Borras, Alba Mañé Martínez, Rafael Marés, Jaume Viñas i Gaya, Laia Seró, Paula Rodríguez, Gislaine Castilho, Angela Monterde Ortega, Silvia Reverté, Joan Josep Baiges, Gisela Martín Ozaeta, Sonia Escalante, Patricia Esteve Belloch, Iago Payo, Júlia Saura Salvado, Josep M Soler Insa, Ester Tio Vilamala, Josep Abos Navarro, Héctor Cruz Tabuenca, Tamara Canento Sánchez, Elisabet Roldán, Elsa Puiggrós Rubiol, Elisabet Franquet, Lidia Fuentes, Javier Donaire, Elena Martí, Laura Giménez, Junior Gil Vázquez, Eloisa Nieto Clara Gris Ambrós, Puri Rodríguez, José Félix Oletta, Pilar Pons Mellado, Bárbara Gómez, Vergilin Raileau, Oscar Pardina, Jordi Mercadal, María López-Diéguez, Pilar Pérez, Lourdes Gabarró, María Orriols, José Carlos Molina, Joan Josep Canet, Mireia Roca, Muriel Álvaro, Francesc Boneu, Georgina Giménez, Jaume Albà, Francesc Gibert, Jéssica Garcia, Patricia Barragan, Gustavo Jurado, Vanesa Pascual_Medicina Interna, Josep Sabaté Ortega, Joan Amaurys Martínez Solano, Víctor Fernández, Mónica Torres, Ana Belén Montero Alvaredo, Laura Redondo Parejo, Josep Maria Aragonés, Anna Bullón, Cora Loste, Paula González, Neker Bejarano, Francisco Sanchez, Gianni Lucchetti, Xavier Pla, Dr Javier Gimeno, Esteban Reynaga, Montse Barcons, Gabriel Celedón, Juan Ortiz, Dr Goran Anastasovski, Dr Oscar Mascaró, Dr Javier Diez de los Ríos, Meritxell Feliu, Anna Ribera, Cristhian Ruiz, Gerard Corominas, Dra Daniella Nunes, Claudia Roca, Nadina Latorre, Lizbeth Yataco, Maricelys Cruz, Nerea Blanco, Santiago Castejón, Claustre Pont Sunyer, Jordi Espinosa Garcia, Rodrigo Paz Martin, Albert de Luis Sanchez, Dolores Espinosa Vivas, Juan Valencia Molina, Planels Palome, Laia Tomas Chaume, Ares Villagrasa Vilella, Marco Bustamante, Anunciación Boltes, Fernando Rodríguez, Itziar Arrieta, Jordi Ciurans Molist, Barnés Andreu, Ernest Palomeras Soler, Nicolau Guanyabens Buscà, Manuel Daza López, Jordi Bigas Farreres, Virginia Casado Ruiz, Desiree Muriana Batiste, Mª Pilar Sanz Cartagena, Eulalia Cabot de Vega, Josep Bassa Real, Hector Pelaez Roman, César Socolich, Josep Mª Alonso Camp, Antonio Tomás Cano Orgaz, Mª Pilar Fossas Felip, Nicolás Morón, Sandra Bacca, Mauricio Molina, Francesc Casarramona, Lorena Elias, Muhammad Zidane Bukaei, Jose Antonio Martos Gutierrez, Judith Lopez Escuin, Cristina Olaizola, Yolexis López Vargas, Juan Jiménez Oyonarte, Rashida Soultana, Eduardo Sanjurjo Golpe, Esther Salvador, Guillem Vila, Marcos Serrano, Matilde Nuria López Claverol, Marian Lamolla, Miquel Amate, Adriana Rodriguez, Ruth Romero, Montgomery del Carpio, Ana Isabel Hernandez, Julián Martín, M Carmen Rosas, Antonio Nogueroles, Sorilandy Encarnación, Augusto Robles, Jose Antonio Herrera, Roger Gavilán, Toghrol Mameghani, Gastón Araujo, M.Angeles Garrido Morales, Enric Ramon Albert Segui, Eva Fernandez Climent, Francesc Paris Pujol, Mireia Judit Garrofé Seira, Lucía Gómez Pía, Fernando Salleres Nuñez, Cristina Aguar Peñalver, Cristina Vaz Lopes, Elisenda Ribera Tasa, Carmen Repullo Vilchez, Modesto Sánchez Zambrana, Beatriu Suescun Ribas, Inés Vilà Panés, Montserrat Vila Planavila, Alicia Vaqueiro Lorenzo, Meritxell Sabartés Guixes, Jorge Medina, David Sambrano, Javi Zamarreño, Carmen Pirela, Paola Vélez, Luis Cajamarca, Honey Pérez, Yarles Martínez, Jesus Alexander Gonçalves, Carles Regordosa, Claudia Mormeneo, Laura Griu, Maria Francia Colina, Enric Farik, Dolors Carrión Duch, Carles Badenas, Oscar Bernal, Núria Agramunt, Shyrlei Morales, Victoria Reynoso, Miguel Guerrero, Primitivo Romera Cid, Mònica Folqué, Claudia Pedroza, Adnan Hachem, Íñigo Soteras Martínez, Xavier Verdera García, Mercè López Amorós, Xavier Costa Subirós, Marta Cufí Benet, Cecile Van Eendenburg, Teresa Osuna, Dra Gina Santos, Dra Mireia Pallisera, Dr Lluís Gonzalo Oliva, Dra Gemma Sanchez, Dr Xavier Basurto, Dr Ludgi Vivoda, Dr Richard Van der Kleyn, Dra Laura Robles, Ana Cabanelas Barranco, Mª Cruz Almendros, Marc Pérez Oliveras, Amelia Fernández Álvarez, Maria Rybyeva, Antoni Viñas, Maria Barcons, Joaquim Danès Alberto Tavera, Pablo Burbano, Cintie López, David Cruz, Paula Bisbe, Nora Fernández, Juan Carlos Palacio, Eduardo Fraiz, Oriol Aguiló, Rollmy Amorodjo, John Velázquez, Elena Sánchez, Jaume Español, Judit Perez de Celis, Anna Coll, Glòria Díaz, Margarida Vergés i Sala, Mª Ángels Casas Capdevila, Yosmairy Yoselin Ferrini, Aitor Gorriz, Diego-Javier Cucurell Navarro, Dulce Velásquez, Jaume Pla Soler, Josep González, Julian David Higuera, Lina Cuellar, Liza Margarita Miniello, Lluis Pujol, Sorin Cracan, Mora Vives, M Angela, Lopez Lopez, Montse Gorchs Molist, Delofeu Anna, Silvia Solà Muñoz, Ferreres Yolanda, Carol Pujalte, Elisabeth Téllez Marín, Yolanda Font Casas, Sara Hernández Luque, Joaquim Mejias Sendra, Francesca Mellado Valero, Campos Escala, Galup De Lacanal, Lopez Diaz, Castillo Paramio, Català Estopà, Español Moreda, Calafell Majo, Carballo Almeida, Castro Naval, M Elena, Cregut Ruiz, Pere Lluis, Deulofeu Font, Fabregat Sanjuan, Joan Pere, Fontquerni Gorchs, Forés Bellés, Joan Antoni, Gomez Herrera, Juan Carlos, Hijazo Prades, Itzaina Torvisco, Marti Rovira, Obiols Gonzalez, Olive Cavero, Querol Gil, M Soledad, Rico Rodriguez, Rios Sambernardo, Ropero Molina, Jose Ramon, Sanchez Valero, Santos Arevalo, Maria Jose, Soto Garcia, Maria Angeles, Tebar Escribano, Torres Garcia, Pedro José, Verdes Carrion, M Isabel, Verge Lopez, Juan Jose, Lopez Canela, M Angeles, Lucas Guarque, Morales Alvarez, Jorge Arnulfo, Morell Fornieles, Subirats Gomez, Maria Teresa, Torello Masa, Miquel, Val Lopez, Maria Mercedes, Palmero Reyes, Juan Manuel, Rodriguez Forne, Ruana Turiel, Sanchez Gonzalez, Sebastia Gornals, Abrio Rico, Albert Gual Falip, Aznar Oliveros, Brugues Perotti, Calvet Molinero, Catells Franco, Corrales Medina, Daroca Miro, Duran Marquez, Feliu Pradas, Figueras Casanova, Garcia Tortajada, Grajera Gallego, Azahara del Mar, Las Arroyo, Dulcenombre de Jesus, Laserreta Sanz, Llambrich Vidal, Monllao Corral, Morales de la Cruz, Moreno Blanco, Orejuela Orgaz, Piñana Suazo, Pons Minguillon, Rodríguez Gómez, José Carlos, Rodriguez Pereira, Sedo Porcel, Anna, Sevil Villar, Sierra Lopez, Torres Romero, Trepat Calveres, Anna, Ventura Arnella, Acera Gil, M Teresa, Biesot Vico, Castro Galea, Rosa Maria, Escorcia Chafer, Juan Antonio, Gil Faure, Hernandez Luque, Jimenez Delgado, Mallafre Gay, M. Angel, Olivares Sanzo, Pubill Fondevila, Sabate Fort, Segovia Agámez, Antonio Carlos, Turata Longaretti, Valle Hernandez, Trayner Guixens, Aguilar Valor, Aguirre Alvarez, Alastrue Naval, Alferez Baquero, Alonso Marne, Aloy Orozco, Alvarez Colino, Alvarez Peñuela, Ameller Cirilo, Maria Vanessa, Andujar Guerrero, Estefania Remedios, Auladell Sillero, Azcarate Sorbet, Basany Genesca, Benavent Barduena, Benito Tudela, Blanch Pardo, Boluda Pla, Bonilla Gonzalez, Bru Serramalera, Burnat Andreu, Caballero Calvo-Rayo, Calvo Casellas, Camps Mombiela, Cano Bresme, Carcelen Fernandez, Caro Solà, Casasas Matavacas, Castanedo Bolado, Cerdeña Cortina, Abella Jane, Laia Collado Borrego, Colom Orri, Comellas Vilanova, Conillera Sole, Cots Torres, Cuchi Estepa, Marc de Sostoa Graell, Laura del Rio Lopez, Delgado Compte, Diaz Bueno, Diaz Maneiro, Andrea Lucia, Domenech Palau, M. Carme, Duran Carasso, Pablo Javier, El Abidi, Escoda Martin, Esteve Casanovas, Fernandez Perez, Ferre Quintero, Flores Escobar, Fontcuberta Abad, Fortes del Valle, Mª Luisa, Franco Quesada, Sara Maria, Franco Romero, Gallego Francisco, Gamiz Gala, Garcia Castañeda, Garcia Rodriguez, Casajuana Gemma, Gomez Arroyo, Gomez Girbau, Gonzalez Fernandez, Gonzalez Gonzalez, Gonzalez Lopez, Gual Obeso, Guerrero Blanco, Guillemas Roca, Guillermo Eudaldo, Sebastia Hernandez, Homar Covas, Hostench Alvarez, Huerta Royo, Ibañez Barcelo, Izquiero Cruz, Jaione Urdangarin Etxetxikia, Juárez Gimenez, Khlifi Alami, Laparra Gasco, Lara Moreales, Lasaosa Medina, Maria Lourdes, Lazaro Cava, Leon Berrar, López Maturana, Lopez Ramirez, López Romero, Lorente Marco, Lorenzo Martin, Lozano Casals, Lujan Nicola, Madrid Diaz, Jose Antonio, Maria Teresa Peris Morales, Marti Clemente, Martinez Castaño, David Natanael, Martinez Gamez, Martinez Gonzalez, Martinez Quesada, Maria de la Cabeza, Marzà Fusté, Melendo Lasheras, Miralles Mestre, Montserrat Puig Pastalle, Montserrate Vidal, Mora Mellado, Morales Ponce, Morera Cabre, Morera Vivet, Mundi Souza, Muñoz Quiles, Navea Rosa, Neira Iglesias, M Asuncion, Nuñez Manrique, Mª Pilar, Obiols Martinez, Pallares Reig, Partegas Torres, Pascual Berengueras, Perez Gamez, Perez Oset, Perez Restrepo, Maria Alejandra, Planas Yeste, Planells Mangado, Puertas Carbonell, Quinteiro Blanco, Rebollar Benavente, Recasens Fernandez, Reyes Gomez, Maria del Carmen, Roca Pou, Rodriguez Ferrer, Rodriguez Franco, Rodriguez Fuertes, Rodriguez Muñoz, Rodriguez Navarro, Roig Iniesta, Romero Gracia, Rovira Brunet, Rovira de Eugenio, Rubio Baena, Ruiz Llorens, Sala Llamazares, San Juan Alaez, Sanchez Segura, Santasusana Soldevilla, Sanz Salmeron, Segura Perez, Serra Balcells, Sorina Dumitras, Teixidor Montoya, Tena Vicente, Tierno Salinas, Ester Ines, Toledo Testa, Tomàs Figueras, Tomas Ruperez, Torrano Garcia-Penche, Torres Esparza, Vazquez Blanco, Vazquez De la Paz, Vazquez Gil, Vazquez Gonzalez, Vidal Meler, Vilalta Cots, Vilches Jimenez, Visser Fernandez, Viu Gavin, Vives Vives, Carmona Jimenez, Francisco Jose, Galobardes Vilches, Gonzalez Gomez, Jodar Manzanera, Marimon Cortes, Marrodan Orive, Martin Bosch, Martorell Lopez, Millares Roca, M Jesus, Miralles Guri, Muliterno Hernandez, Muñoz Oliva, Pons Pujol, Postius Conde, Prieto Arruñada, Quintana Mathé, Rosell Mata, Alvarin Alvarez, Arrufat Flores, Bañuelos Pago, Campo Vilar, Cardus Hidalgo, Castello Gil, Maria Gloria, Castrillo Montsesinos, Clave Garces, Comes Sanroma, Descalzo Sequi, Errando Ricol, Escudero Campillo, Maria del Mar, Fernandez Alvarez, Fernandez Gomez, Franch Espinosa, Freixes Graells, Garcia Plaza, Garcia-Marron Gallego, Hernandez Simancas, Jaraba Armas, Jimenez Ramos, Lopez Oganissian, Madrona Romero, M Rosa, Martinez Millan, Martínez Morón, Merchan Encinas, Moreno Jimenez, Muñoz Rico, Navarro Rodriguez, Nogales Ibañez, Rita Maria, Novillo Viera, Parella Torrabadella, Mari Alba, Pera Villar, Carla Montserrat, Rabella Miralles, Ramis Trilles, Ribera Ortiz, Sastre Perez, Soro Borrega, Tapia Fores, Tellez Bernad, Trenado Alvarez, Felix Martin, Herrero Perez, Lanau Fuster, Lopez Gomariz, Pardo Lozano, Quintana Altimiras, Ventosa Lopez, Almodovar Damian, Alvarez Monterroso, Arambudo Comas, Boullon Garzon, Burgos Capella, Campuzano Garcia, Maria Del Mar, Capdevila Olivas, Carre Marti, Clara Isabel, Carretero Bacaicoa, Cazorla Calderon, Chacon Osuna, Cortes Planas, Cortit Olio, Delhomme Estany, Fructuos Martinez, Garcia Lopez, Pascual Luis, Genis Amill Vallve, Gonzalez Muñoz, Hernaez Ventura, Lavernia Gimenez, Martin Rojo, Martínez Medina, Mayol Barrera, Mercader Pi, Merino Dalmau, Miguel Campodarbe, Moreno Sanchez, Francisco Javier, Penela Barrameda, Prieto Ajenjo, Rodriguez Pareja, Rodríguez Piñar, Rodriguez Tello, Romero Pereda, Sainz Saborido, Santacana Martin, Santos Martinez, Sierra Chavez, Turbau Torres, Vicente Domenech, Villena Esteo, Vives Pertegaz, Baena Gonzalez, Bagaria Pont, Beltran Sanchez, Bonet Alarcon, Borch Ballescà, Buhils Clanchet, Closa Garcia, Colomina Carril, Cristina Fernandez Sanchez, Edurne Judith Fernandez Toledo, Espases Rodriguez, Espert Resa, F Xavier, Fernández Sol, Gonzalez Lugo, Gracia Llesera, Herrada Lendinez, Juliench Liesa, Sandra Alicia, Lopez Ortega, Lopez Yuste, Lozano Villanueva, Lucia Sola Soto, Madrid Castellano, Megias Cano, Daniel Jesus, Montasell Ponce, Montesinos Sospedra, Moya Martinez, Muñoz Herrera, Ocaña Fernandez, Palau Bernal, Perez Sole, Ramon Carbonell, Ribas Lop, Rubio López, Rueda Lopez, Sabat Castaño, Sabata Lara, Salmerón Ramírez, Serra Creus, Serrano Dalmau, Sumasi Mainero, Gonzalo Gabriel, Torello Masa, Valencia Primo, Ana Maria Viñuales Muñoz, Josep Roig, and Verònica Hidalgo

Subjects
Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine
Abstract

Background: We aim to assess whether time of day modified the treatment effect in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion Trial), a cluster-randomized trial that did not demonstrate the benefit of direct transportation to a thrombectomy-capable center versus nearest local stroke center for patients with a suspected large vessel stroke triaged in nonurban Catalonia between March 2017 and June 2020. Methods: We performed a post hoc analysis of RACECAT to evaluate if the association between initial transport routing and functional outcome differed according to trial enrollment time: daytime (8:00 am –8:59 pm ) and nighttime (9:00 pm –7:59 am ). Primary outcome was disability at 90 days, as assessed by the shift analysis on the modified Rankin Scale score, in patients with ischemic stroke. Subgroup analyses according to stroke subtype were evaluated. Results: We included 949 patients with an ischemic stroke, of whom 258 patients(27%) were enrolled during nighttime. Among patients enrolled during nighttime, direct transport to a thrombectomy-capable center was associated with lower degrees of disability at 90 days (adjusted common odds ratio [acOR], 1.620 [95% CI, 1.020–2.551]); no significant difference between trial groups was present during daytime (acOR, 0.890 [95% CI, 0.680–1.163]; P interaction =0.014). Influence of nighttime on the treatment effect was only evident in patients with large vessel occlusion(daytime, acOR 0.766 [95% CI, 0.548–1.072]; nighttime, acOR, 1.785 [95% CI, 1.024–3.112] ; P interaction P interaction >0.1 for all comparisons). We observed longer delays in alteplase administration, interhospital transfers, and mechanical thrombectomy initiation during nighttime in patients allocated to local stroke centers. Conclusions: Among patients evaluated during nighttime for a suspected acute severe stroke in non-urban areas of Catalonia, direct transport to a thrombectomy-capable center was associated with lower degrees of disability at 90 days. This association was only evident in patients with confirmed large vessel occlusion on vascular imaging. Time delays in alteplase administration and interhospital transfers might mediate the observed differences in clinical outcome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02795962.

Published
2023
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8. Reference Intervals and Clinical Utility of Acute Phase Proteins and Serum Proteins Electrophoresis in the Hamadryas Baboon (Papio hamadryas)

Author

Megan L. Cabot, Nicholas G. Dannemiller, Carolyn Cray, and Larry J. Minter

Subjects
protein electrophoresis, acute phase protein, serum amyloid A, General Medicine, hamadryas baboon, Papio hamadryas, C-reactive protein
Abstract

Measurements of specific acute phase proteins (APP) and protein electrophoresis (EPH) fractions have been widely used to better assess the health of species under managed care across numerous taxa. To date, APP assays have not been validated in the hamadryas baboon (Papio hamadryas), and reference intervals have not yet been established. This information is critical for the interpretation of APP and EPH measurements used in the diagnosis of inflammatory diseases during routine veterinary care of this species. To obtain this information, banked serum samples from hamadryas baboons of various age, sex, and health status, under managed care at the North Carolina Zoo, were analyzed. A small pilot study found significantly higher serum amyloid A (SAA) and C-reactive protein (CRP) but not haptoglobin in baboons with acute inflammation compared to healthy counterparts, so these two APPs were investigated further. Reagents for serum amyloid A (SAA) and C-reactive protein (CRP) were validated, although differences in CRP reagents were observed. Based on the results of this study, SAA and CRP were defined as major APPs that were significantly increased in baboons with active inflammation or infection compared to healthy conspecifics. Baboons with acute inflammation additionally had significantly higher gamma globulins compared to healthy baboons. Although mean albumin concentrations were lower in baboons with acute inflammation, the difference from healthy baboons was not statistically significant. This study identifies SAA, CRP, and EPH as useful tools in the diagnosis of inflammatory disease in the hamadryas baboon and establishes reference intervals to aid in the future veterinary care of this species.

Published
2023
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10. Estado de la comunicación organizacional dentro de un consorcio de investigación científica y tecnología

Author

Elizabeth Álvarez Padilla and Esperanza Asencio Cabot

Abstract

El presente artículo aborda la comunicación organizacional dentro de un consorcio de investigación científica y tecnológica y su relación con la gestión de proyectos. Desde un enfoque mixto y una perspectiva sistémica, el objetivo fue diagnosticar el estado de la comunicación organizacional y su relación con la gestión de proyectos realizada en el marco del Consorcio de Investigación del Golfo de México (CIGOM), entre 2018 y 2021. La investigación se desarrolló a partir de la revisión de documentos fundacionales del consorcio, los registros de observación participante y un cuestionario a una muestra representativa de los miembros en 2021. Se encontraron evidencias de una mayor actividad de comunicación en el ámbito interno lo cual ha beneficiado el funcionamiento del consorcio, y una menor actividad hacia el exterior siendo esta un área de desarrollo imprescindible en el futuro inmediato. La gestión del cigom mostró mejores valoraciones en cuanto a liderazgo, motivación, satisfacción y pertenencia, no así para aspectos como el control, la evaluación o los procesos de ajuste y mejoras relacionados con éstos.

Published
2023
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12. Concepción didáctica de entrenamiento de posgrado en línea. Experiencia en universidad cubana

Author

Esperanza De la Caridad SENCIO CABOT and Nilda Orquídea IBARRA LÓPEZ

Subjects
General Medicine
Abstract

l trabajo presenta la investigación desarrollada en la Universidad Central “Marta Abreu” de Las Villas, Cuba, para enfrentar las limitaciones existentes en la creación de entornos virtuales de aprendizaje en línea para la formación continuada de profesionales y tuvo como objetivo: la elaboración de una concepción didáctica para un entrenamiento de posgrado en línea sobre la publicación de artículos en revistas científicas considerando las posibilidades tecnológicas de la plataforma Moodle instalada en la institución. El diseño metodológico seguido, quedó enmarcado fundamentalmente dentro del enfoque de la investigación-acción y la sistematización, aunque fueron empleados otros métodos teóricos y empíricos durante las tres etapas que abarcó la investigación. La concepción didáctica del entrenamiento en línea, se fue construyendo a lo largo del proceso investigativo y fue comprobada su funcionalidad durante el propio proceso, alcanzándose resultados positivos en su implementación. Palabras clave: Entornos virtuales de aprendizaje, plataforma Moodle, educación a distancia, superación profesional, fundamentos didácticos.

Published
2023
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14. Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

Author

Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, and José Miguel Vela

Subjects
General Pharmacology, Toxicology and Pharmaceutics
Published
2023
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15. Software assistants in software engineering: A systematic mapping study

Author

Maxime Savary‐Leblanc, Lola Burgueño, Jordi Cabot, Xavier Le Pallec, Sébastien Gérard, Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Lille, Open University of Catalonia [Barcelona], Universidad de Málaga [Málaga] = University of Málaga [Málaga], Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Spanish Government, Grant/Award Numbers: PID2020-114615RB-I00,PID2021-125527NB-I00, ECSEL Joint Undertaking (JU), Grant/AwardNumbers: 101007260, 101007350, and European Project: 101007350,AIDOaRt

Subjects
[INFO]Computer Science [cs], Software
Abstract

International audience; The increasing essential complexity of software systems makes current software engineering methods and practices fall short in many occasions. Software assistants have the ability to help humans achieve a variety of tasks, including the development of software. Such assistants, which show human-like competences such as autonomy and intelligence, help software engineers do their job by empowering them with new knowledge. This article investigates the research efforts that have been conducted on the creation of assistants for software design, construction and maintenance paying special attention to the user-assistant interactions. To this end, we followed the standard systematic mapping study method to identify and classify relevant works in the state of the art. Out of the 7580 articles resulting from the automatic search, we identified 112 primary studies that present works which qualify as software assistants. We provide all the resources needed to reproduce our study. We report on the trends and goals of the assistants, the tasks they perform, how they interact with users, the technologies and mechanisms they exploit to embed intelligence and provide knowledge, and their level of automation. We propose a classification of software assistants based on interactions and present an analysis of the different automation patterns. As outcomes of our study, we provide a classification of software assistants dealing with the design, construction and maintenance phases of software development, we discuss the results, identify open lines of work and challenges and call for new innovative and rigorous research efforts in this field.

Published
2022
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16. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas

Author

Alvaro Garcia-Tornel, Monica Millan, Marta Rubiera, Alejandro Bustamante, Manuel Requena, Laura Dorado, Marta Olivé-Gadea, Xavier Jiménez, Angels Soto, Marisol Querol, Maria Hernández-Pérez, Meritxell Gomis, Pere Cardona, Xabier Urra, Francesc Purroy, Yolanda Silva, Xavier Ustrell, Patricia Esteve, Mercè Salvat-Plana, Miquel Gallofré, Carlos Molina, Antoni Dávalos, Tudor Jovin, Sonia Abilleira, Marc Ribo, Natalia Pérez de la Ossa, Marc Ribó Jacobi, Estela Sanjuan, Katherine Santana, Noelia Rodríguez, Jorge Pagola, David Rodriguez-Luna, Olga Maisterra, Estevo Santamarina, Marian Muchada, Jesús Juega, Sandra Boned, Antonio Palasi Franco, Álvaro García -Tornel, Matías Deck, Victoria Sala, Lucía Muñoz, Mónica Millán, Elena López-Cancio, María Hernández-Pérez, Jordi Ciurans, Daniela Samaniego, Tamara Canento, Lorena Martin, Anna Planas, Joaquin Broto, Agustín Sorrentino, Martí Paré, Nuole Zhu, Alicia Garrido, Laia Grau, Ane Miren Crespo, Silvia Presas, Miriam Almendrote, Alba Ramos, Giuseppe Lucente, Lourdes Ispierto, Manuel Lozano, Juan Luis Becerra, Marta Jiménez, Dolores Vilas Rolán, Nicolas Guanyabens, Josep Sanchez-Ojanguren, Alicia Martínez-Piñeiro, Sara Forcén, Mireia Gea, Marta Álvarez, Anna Ramos, Manuel Domínguez Lizarbe, Sara, Rubio Guerra, Irene Bragado, Andrea Arbex, Luis Rodríguez, Pere Cardona Portela, Helena Quesada García, Blanca Lara Rodríguez, Nuria Cayuela, Julia Miró, Clara Marzal, Andrés Paipa, Sergio Campoy, Ana Núñez, Pablo Arroyo, Sarah Besora, Vanessa Adell, Jaume Campdelacreu, Montse Alemany Martí, Belén González, Laura Bau Vila, Marta Fiter Crespo, Anna Berbel, Ma. Cristina Villaescusa Urbaneja, Núria Guillen, Nuria Vidal, Patricia Valentina Vérez Santamaria, Diego Herrero Navarro, Marta Simó, Mercedes Falip, Elisabeth Matas, Neus Mongay Ochoa, Ariadna Gifreu, Albert Muñoz, Lucía Romero, Eduard Portell, Guillermo Hernández Perez, F. Ruiz Esteve, Silvia Teixidor, Augusto Salazar Talavera, Roser Gómez, Xabier Urra Nuin, Martha Vargas, Ángel Chamorro, Sergio Amaro, Laura Llull, Arturo Renú, Salvatore Rudilosso, Raquel Sánchez del Valle, Helena Ariño, Nuria Solà, Delón la Puma, Francisco Gil, Juan Bernardo Gómez, Nuria Matos, Neus Falgàs, Sergi Borrego, Almudena Sánchez, Mircea Balasa, Carmen Montejo, Mar Guasp, David Reyes, Pablo Sánchez Cervilla, Jose Miguel Contador, Victor Augusto Vera Monge, Oscar Ramos, Alejandro Rodríguez, Ana Rodríguez Campello, Gemma Romeral Ballester, Mireia Llop Trujillano, Eva Giralt Steinhauer, Elisa Cuadrado Godia, Angel Javier Ois Santiago, Jordi Jimenez Conde, Joan Martí Fábregas, Daniel Guisado, Luís Prats, Pol Camps, Raquel Delgado, Alejandro Martínez Domeño, Rebeca Marín, David Cànovas, Jordi Estela, Marta Ros, Sonsoles Aranceta, Jordi Espinosa, Marta Rubio, Cristina Lafuente, Oriol Barrachina, Alicia Anguita, Anna Reverter, Carmen García, Gemma Sansa, Mariona Hervas, Monica Crosas, Tania Delgado, Jerzy Krupinski, Sonia Huertas Folch, Gemma Muñoz Gamito, Josep Trenado Alvarez, Teresa Subirana, Jessica Molina, Laura Comes Romero, Gemma Guardia Valls, Miriam Jover, Javier Joaquín Sotova, Sonia Mª García Sánchez, Sebastian Valenzuela (intensivista), Manuel Gómez-Choco, Juan José Mengual, M. Àngels Font, Mª Isabel Gómez Ruiz, Irati Zubizarreta, Susana Fernández González, Laura Gubieras, Carmen E. Cobos, Luis Mena Romo, Nuria Caballol, Luis Cano, Joaquín Serena Leal, Mikel Terceño Izarra, Irene Bragado Trigo, Saima Bashir Viturro, Laura Pardo Albiñana, Montserrat Reina Garrido, Carla Marco Cazcarra, Karol Enrique Uscamaita, Fabian Márquez, Cristina Coll, Mar Irida Lloret Villlas, Berta Solano Vila, Berta Alemany Perna, Daniel López Domínguezl, Mercedes de Lera, Anna Cots Foraster, Urszula Bojaryn, Ikram Benabdelhak, Gerard Mauri Capdevila, Jordi Sanahuja Montesinos, Daniel Vázquez, José Vicente Hervás, Cristina González, Alejandro Quílez, Mikel Vicente Pascual, María Ruiz, Yolanda Riba, M. Pilar Gil Villar, Cristina García, Xavier Ustrell Roig, Mònica Baldrich Mora, Anna Pellisé Guinjoan, Judit Borras, Alba Mañé Martínez, Rafael Marés, Jaume Viñas i Gaya, Laia Seró, Alan Flores, Paula Rodríguez, Gislaine Castilho, Angela Monterde Ortega, Silvia Reverté, Josep Zaragoza, Joan Josep Baiges, Gisela Martín Ozaeta, Sonia Escalante, Iago Payo, Júlia Saura Salvado, Natalia Mas Sala, Josep M Soler Insa, Ester Tio Vilamala, Josep Abos Navarro, Héctor Cruz Tabuenca, Tamara Canento Sánchez, Elisabet Roldán, Elsa Puiggrós Rubiol, Elisabet Franquet, Lidia Fuentes, Javier Donaire, Elena Martí, Laura Giménez, Junior Gil Vázquez, Eloisa Nieto Clara Gris Ambrós, Puri Rodríguez, José Félix Oletta, Pilar Pons Mellado, Catena, Bárbara Gómez, Vergilin Raileau, Esther Catena Ruíz, Oscar Pardina, Jordi Mercadal, María López-Diéguez, Pilar Pérez, Lourdes Gabarró, María Orriols, Joan Josep Canet, Mireia Roca, Muriel Álvaro, Francesc Boneu, Georgina Giménez, Jaume Albà, Francesc Gibert, Jéssica Garcia, Patricia Barragan, Gustavo Jurado, Josep Sabaté Ortega, Joan Amaurys Martínez Solano, Víctor Fernández, Mónica Torres, Ana Belén Montero Alvaredo, Laura Redondo Parejo, Josep Maria Aragonés, Anna Bullón, Cora Loste, Paula González, Neker Bejarano, Francisco Sanchez, Gianni Lucchetti, Xavier Pla, Javier Gimeno, Esteban Reynaga, Montse Barcons, Gabriel Celedón, Juan Ortiz, Goran Anastasovski, Oscar Mascaró, Javier Diez de los Ríos, Meritxell Feliu, Anna Ribera, Cristhian Ruiz, Gerard Corominas, Daniella Nunes, Claudia Roca, Nadina Latorre, Lizbeth Yataco, Maricelys Cruz, Nerea Blanco, Santiago Castejón, Dolores Cocho Calderón, Claustre Pont Sunyer, Jordi Espinosa Garcia, Rodrigo Paz Martin, Albert de Luis Sanchez, Dolores Espinosa Vivas, Juan Valencia Molina, Gemma, Planels Palome, Laia Tomas Chaume, Ares Villagrasa Vilella, Marco Bustamante, Anunciación Boltes, Fernando Rodríguez, Itziar Arrieta, Jordi Ciurans Molist, Barnés Andreu, Ernest Palomeras Soler, Nicolau Guanyabens Buscà, Manuel Daza López, Jordi Bigas Farreres, Virginia Casado Ruiz, Desiree Muriana Batiste, Mª Pilar Sanz Cartagena, Eulalia Cabot de Vega, Josep Bassa Real, Hector Pelaez Roman, César Socolich, Josep Mª Alonso Camp, Antonio Tomás Cano Orgaz, Mª Pilar Fossas Felip, Nicolás Morón, Sandra Bacca, Mauricio Molina, Francesc Casarramona, Lorena Elias, Muhammad Zidane Bukaei, Jose Antonio Martos Gutierrez, Judith Lopez Escuin, Cristina Olaizola, Yolexis López Vargas, Juan Jiménez Oyonarte, Rashida Soultana, Eduardo Sanjurjo Golpe, Esther Salvador, Guillem Vila, Marcos Serrano, Matilde Nuria López Claverol, Marian Lamolla, Miquel Amate, Adriana Rodriguez, Ruth Romero, Montgomery del Carpio, Ana Isabel Hernandez, Julián Martín, M Carmen Rosas, Antonio Nogueroles, Sorilandy Encarnación, Augusto Robles, Jose Antonio Herrera, Roger Gavilán, Toghrol Mameghani, Gastón Araujo, M.Angeles Garrido Morales, Enric Ramon Albert Segui, Eva Fernandez Climent, Francesc Paris Pujol, Mireia Judit Garrofé Seira, Lucía Gómez Pía, Fernando Salleres Nuñez, Cristina Aguar Peñalver, Cristina Vaz Lopes, Elisenda Ribera Tasa, Carmen Repullo Vilchez, Modesto Sánchez Zambrana, Beatriu Suescun Ribas, Inés Vilà Panés, Montserrat Vila Planavila, Alicia Vaqueiro Lorenzo, Meritxell Sabartés Guixes, Jorge Medina, David Sambrano, Javi Zamarreño, Carmen Pirela, Paola Vélez, Luis Cajamarca, Honey Pérez, Yarles Martínez, Jesus Alexander Gonçalves, Carles Regordosa, Claudia Mormeneo, Laura Griu, Maria Francia Colina, Enric Farik, Dolors Carrión Duch, Carles Badenas, Oscar Bernal, Núria Agramunt, Shyrlei Morales, Victoria Reynoso, Miguel Guerrero, Primitivo Romera Cid, Mònica Folqué, Claudia Pedroza, Adnan Hachem, Íñigo Soteras Martínez, Xavier Verdera García, Mercè López Amorós, Xavier Costa Subirós, Marta Cufí Benet, Cecile Van Eendenburg, Teresa Osuna, Dra Gina Santos, Mireia Pallisera, Lluís Gonzalo Oliva, Gemma Sanchez, Xavier Basurto, Ludgi Vivoda, Richard Van der Kleyn, Laura Robles, Ana Cabanelas Barranco, Mª Cruz Almendros, Marc Pérez Oliveras, Amelia Fernández Álvarez, Maria Rybyeva, Antoni Viñas, Maria Barcons, Joaquim Danès Alberto Tavera, Pablo Burbano, Cintie López, David Cruz, Paula Bisbe, Nora Fernández, Juan Carlos Palacio, Eduardo Fraiz, Oriol Aguiló, Rollmy Amorodjo, John Velázquez, Elena Sánchez, Jaume Español, Judit Perez de Celis, Anna Coll, Glòria Díaz, Margarida Vergés i Sala, Mª Ángels Casas Capdevila, Yosmairy Yoselin Ferrini, Aitor Gorriz, Diego-Javier Cucurell Navarro, Dulce Velásquez, Jaume Pla Soler, Josep González, Julian David Higuera, Lina Cuellar, Liza Margarita Miniello, Lluis Pujol, Sorin Cracan, Mora Vives, M Angela, Lopez Lopez, null Anabel, Montse Gorchs Molist, Delofeu Anna, Silvia Solà Muñoz, Ferreres Yolanda, Carol Pujalte, Elisabeth Téllez Marín, Yolanda Font Casas, Sara Hernández Luque, Joaquim Mejias Sendra, Francesca Mellado Valero, Campos Escala, Galup De Lacanal, Lopez Diaz, Castillo Paramio, Català Estopà, Español Moreda, Calafell Majo, Carballo Almeida, Castro Naval, M Elena, Cregut Ruiz, Pere Lluis, Deulofeu Font, Fabregat Sanjuan, Joan Pere, Fontquerni Gorchs, Forés Bellés, Joan Antoni, Gomez Herrera, Juan Carlos, Hijazo Prades, Itzaina Torvisco, Marti Rovira, Obiols Gonzalez, Olive Cavero, Querol Gil, M Soledad, Rico Rodriguez, Rios Sambernardo, Ropero Molina, Jose Ramon, Sanchez Valero, Santos Arevalo, Maria Jose, Soto Garcia, Maria Angeles, Tebar Escribano, Torres Garcia, Pedro José, Verdes Carrion, M Isabel, Verge Lopez, Juan Jose, Lopez Canela, M Angeles, Lucas Guarque, Morales Alvarez, Jorge Arnulfo, Morell Fornieles, Subirats Gomez, Maria Teresa, Torello Masa, Val Lopez, Maria Mercedes, Palmero Reyes, Juan Manuel, Rodriguez Forne, Ruana Turiel, Sanchez Gonzalez, Sebastia Gornals, Abrio Rico, Albert Gual Falip, Aznar Oliveros, Brugues Perotti, Calvet Molinero, Catells Franco, Corrales Medina, Daroca Miro, Duran Marquez, Feliu Pradas, Figueras Casanova, Garcia Tortajada, Grajera Gallego, Azahara del Mar, Las Arroyo, Dulcenombre de Jesus, Laserreta Sanz, Llambrich Vidal, Monllao Corral, Morales de la Cruz, Moreno Blanco, Orejuela Orgaz, Piñana Suazo, Pons Minguillon, Rodríguez Gómez, José Carlos, Rodriguez Pereira, Sedo Porcel, Sevil Villar, Sierra Lopez, Torres Romero, Trepat Calveres, Ventura Arnella, Acera Gil, M Teresa, Biesot Vico, Castro Galea, Rosa Maria, Escorcia Chafer, Juan Antonio, Gil Faure, Hernandez Luque, Jimenez Delgado, Mallafre Gay, M. Angel, Olivares Sanzo, Pubill Fondevila, Sabate Fort, Segovia Agámez, Antonio Carlos, Turata Longaretti, Valle Hernandez, Trayner Guixens, Aguilar Valor, Aguirre Alvarez, Alastrue Naval, Alferez Baquero, Alonso Marne, Cristina, Aloy Orozco, Alvarez Colino, Alvarez Peñuela, Ameller Cirilo, Maria Vanessa, Andujar Guerrero, Estefania Remedios, Auladell Sillero, Azcarate Sorbet, Basany Genesca, Benavent Barduena, Benito Tudela, Blanch Pardo, Boluda Pla, Bonilla Gonzalez, Bru Serramalera, Burnat Andreu, Caballero Calvo-Rayo, Calvo Casellas, Camps Mombiela, Cano Bresme, Carcelen Fernandez, Caro Solà, Casasas Matavacas, Castanedo Bolado, Cerdeña Cortina, Abella Jane, Laia Collado Borrego, Colom Orri, Comellas Vilanova, Conillera Sole, Cots Torres, Cuchi Estepa, de Sostoa Graell, del Rio Lopez, Delgado Compte, Diaz Bueno, Diaz Maneiro, Andrea Lucia, Domenech Palau, M. Carme, Duran Carasso, Pablo Javier, El Abidi, Escoda Martin, Esteve Casanovas, Fernandez Perez, Ferre Quintero, Flores Escobar, Fontcuberta Abad, Fortes del Valle, Mª Luisa, Franco Quesada, Sara Maria, Franco Romero, Gallego Francisco, Gamiz Gala, Alicia, Garcia Castañeda, Garcia Rodriguez, Casajuana Gemma, Gomez Arroyo, Gomez Girbau, Gonzalez Fernandez, Gonzalez Gonzalez, Gonzalez Lopez, Gual Obeso, Guerrero Blanco, Guillemas Roca, Guillermo Eudaldo, Hernandez Sebastia, Homar Covas, Hostench Alvarez, Huerta Royo, Ibañez Barcelo, Izquiero Cruz, Jaione Urdangarin Etxetxikia, Juárez Gimenez, Khlifi Alami, Laparra Gasco, Lara Moreales, Lasaosa Medina, Maria Lourdes, Lazaro Cava, Leon Berrar, López Maturana, Lopez Ramirez, López Romero, Lorente Marco, Lorenzo Martin, Lozano Casals, Lujan Nicola, Madrid Diaz, Jose Antonio, Maria Teresa Peris Morales, Marti Clemente, Martinez Castaño, David Natanael, Martinez Gamez, Martinez Gonzalez, Martinez Quesada, Maria de la Cabeza, Marzà Fusté, Mireia, M Conillera, Melendo Lasheras, Miralles Mestre, Montserrat Puig Pastalle, Montserrate Vidal, Mora Mellado, Morales Ponce, Morera Cabre, Morera Vivet, Mundi Souza, Muñoz Quiles, Navea Rosa, Neira Iglesias, M Asuncion, Nuñez Manrique, Mª Pilar, Obiols Martinez, Pallares Reig, Partegas Torres, Pascual Berengueras, Perez Gamez, Perez Oset, Perez Restrepo, Maria Alejandra, Planas Yeste, Planells Mangado, Puertas Carbonell, Quinteiro Blanco, Rebollar Benavente, Recasens Fernandez, Reyes Gomez, Maria del Carmen, Roca Pou, Rodriguez Ferrer, Rodriguez Franco, Rodriguez Fuertes, Rodriguez Muñoz, Rodriguez Navarro, Roig Iniesta, Romero Gracia, Rovira Brunet, Rovira de Eugenio, Rubio Baena, Ruiz Llorens, Sala Llamazares, San Juan Alaez, Sanchez Segura, Santasusana Soldevilla, Sanz Salmeron, Segura Perez, Serra Balcells, Sorina Dumitras, Teixidor Montoya, Tena Vicente, Tierno Salinas, Ester Ines, Toledo Testa, Tomàs Figueras, Tomas Ruperez, Torrano Garcia-Penche, Torres Esparza, Florenc Uku, Vazquez Blanco, Vazquez De la Paz, Vazquez Gil, Vazquez Gonzalez, Vidal Meler, Vilalta Cots, Vilches Jimenez, Visser Fernandez, Viu Gavin, Vives Vives, Carmona Jimenez, Francisco Jose, Galobardes Vilches, Gonzalez Gomez, Jodar Manzanera, Marimon Cortes, Marrodan Orive, Martin Bosch, Martorell Lopez, Millares Roca, M Jesus, Miralles Guri, Muliterno Hernandez, Muñoz Oliva, Pons Pujol, Postius Conde, Prieto Arruñada, Quintana Mathé, Rosell Mata, Alvarin Alvarez, Arrufat Flores, Bañuelos Pago, Campo Vilar, Cardus Hidalgo, Castello Gil, Maria Gloria, Castrillo Montsesinos, Clave Garces, Comes Sanroma, Descalzo Sequi, Errando Ricol, Escudero Campillo, Maria del Mar, Fernandez Alvarez, Fernandez Gomez, Franch Espinosa, Freixes Graells, Garcia Plaza, Garcia-Marron Gallego, Hernandez Simancas, Jaraba Armas, Jimenez Ramos, Lopez Oganissian, Madrona Romero, M Rosa, Martinez Millan, Martínez Morón, Merchan Encinas, Moreno Jimenez, Muñoz Rico, Navarro Rodriguez, Nogales Ibañez, Rita Maria, Novillo Viera, Parella Torrabadella, Mari Alba, Pera Villar, Carla Montserrat, Rabella Miralles, Ramis Trilles, Ribera Ortiz, Sastre Perez, Soro Borrega, Tapia Fores, Tellez Bernad, Trenado Alvarez, Felix Martin, Herrero Perez, Lanau Fuster, Lopez Gomariz, Pardo Lozano, Quintana Altimiras, Ventosa Lopez, Almodovar Damian, Alvarez Monterroso, Arambudo Comas, Boullon Garzon, Burgos Capella, Campuzano Garcia, Maria Del Mar, Capdevila Olivas, Carre Marti, Clara Isabel, Carretero Bacaicoa, Cazorla Calderon, Chacon Osuna, Cortes Planas, Cortit Olio, Delhomme Estany, Fructuos Martinez, Garcia Lopez, Pascual Luis, Genis Amill Vallve, Gonzalez Muñoz, Hernaez Ventura, Lavernia Gimenez, Martin Rojo, Martínez Medina, Mayol Barrera, Mercader Pi, Merino Dalmau, Miguel Campodarbe, Moreno Sanchez, Francisco Javier, Alba Mari, Penela Barrameda, Prieto Ajenjo, Rodriguez Pareja, Rodríguez Piñar, Javier Francisco, Rodriguez Tello, Romero Pereda, Sainz Saborido, Santacana Martin, Santos Martinez, Sierra Chavez, Turbau Torres, Vicente Domenech, Villena Esteo, Vives Pertegaz, Baena Gonzalez, Bagaria Pont, Beltran Sanchez, Bonet Alarcon, Borch Ballescà, Buhils Clanchet, Closa Garcia, Colomina Carril, Cristina Fernandez Sanchez, Fernandez Toledo Edurne Judith, Espases Rodriguez, Espert Resa, F Xavier, Fernández Sol, Gonzalez Lugo, Gracia Llesera, Herrada Lendinez, Juliench Liesa, Sandra Alicia, Lopez Ortega, Lopez Yuste, Lozano Villanueva, Lucia Sola Soto, Madrid Castellano, Megias Cano, Daniel Jesus, Montasell Ponce, Montesinos Sospedra, Moya Martinez, Muñoz Herrera, Ocaña Fernandez, Palau Bernal, Perez Sole, Ramon Carbonell, Ribas Lop, Rubio López, Rueda Lopez, Sabat Castaño, Sabata Lara, Salmerón Ramírez, Serra Creus, Serrano Dalmau, Sumasi Mainero, Gonzalo Gabriel, Valencia Primo, Ana Maria Viñuales Muñoz, Josep Roig, and Verònica Hidalgo.

Subjects
Stroke, Advanced and Specialized Nursing, Treatment Outcome, Endovascular Procedures, Humans, Neurology (clinical), Cardiology and Cardiovascular Medicine, Brain Ischemia, Ischemic Stroke, Thrombectomy, Workflow
Abstract

Background: We aim to compare the outcome of patients from urban areas, where the referral center is able to perform thrombectomy, with patients from nonurban areas enrolled in the RACECAT trial (Direct Transfer to an Endovascular Center Compared to Transfer to the Closest Stroke Center in Acute Stroke Patients With Suspected Large Vessel Occlusion). Methods: Patients with suspected large vessel occlusion stroke, as evaluated by a Rapid Arterial Occlusion Evaluation score of ≥5, from urban catchment areas of thrombectomy-capable centers during RACECAT trial enrollment period were included in the Stroke Code Registry of Catalonia. Primary outcome was disability at 90 days, as assessed by the shift analysis on the modified Rankin Scale score, in patients with an ischemic stroke. Secondary outcomes included mortality at 90 days, rate of thrombolysis and thrombectomy, time from onset to thrombolysis, and thrombectomy initiation. Propensity score matching was used to assemble a cohort of patients with similar characteristics. Results: The analysis included 1369 patients from nonurban areas and 2502 patients from urban areas. We matched 920 patients with an ischemic stroke from urban areas and nonurban areas based on their propensity scores. Patients with ischemic stroke from nonurban areas had higher degrees of disability at 90 days (median [interquartle range] modified Rankin Scale score, 3 [2–5] versus 3 [1–5], common odds ratio, 1.25 [95% CI, 1.06–1.48]); the observed average effect was only significant in patients with large vessel stroke (common odds ratio, 1.36 [95% CI, 1.08–1.65]). Mortality rate was similar between groups(odds ratio, 1.02 [95% CI, 0.81–1.28]). Patients from nonurban areas had higher odds of receiving thrombolysis (odds ratio, 1.36 [95% CI, 1.16–1.67]), lower odds of receiving thrombectomy(odds ratio, 0.61 [95% CI, 0.51–0.75]), and longer time from stroke onset to thrombolysis (mean difference 38 minutes [95% CI, 25–52]) and thrombectomy(mean difference 66 minutes [95% CI, 37–95]). Conclusions: In Catalonia, Spain, patients with large vessel occlusion stroke triaged in nonurban areas had worse neurological outcomes than patients from urban areas, where the referral center was able to perform thrombectomy. Interventions aimed at improving organizational practices and the development of thrombectomy capabilities in centers located in remote areas should be pursued. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02795962.

Published
2022
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17. Limitaciones en la escritura de artículos de investigación educativa. Estudio con fines didácticos para mejorar la preparación de autores

Author

Nilda Ibarra López and Esperanza de la Caridad Asencio Cabot

Subjects
Library and Information Sciences
Abstract

El trabajo muestra un estudio acerca de las principales limitaciones que se presentan en los artículos de investigación en el área de las Ciencias Pedagógicas, con el propósito de contribuir a apoyar la preparación de los autores en la escritura científica en esa rama del saber, en la formación posgraduada. El estudio tuvo un carácter descriptivo, con un enfoque cualitativo, empleó como método general el análisis documental, a partir de la valoración de informes, dictámenes, paneles de revisión, entre otros documentos, procedentes de la revisión de manuscritos en el formato referido correspondientes al ámbito de la educación. Como resultado del análisis de los datos recogidos en la muestra seleccionada, fueron identificadas las principales regularidades o tendencias que evidencian las limitaciones en la escritura de los artículos y se precisan algunas pautas o recomendaciones para perfeccionar los mismos. Se considera que los resultados del estudio pueden ser empleados con fines didácticos, para apoyar la preparación de los docentes que investigan en el área de la educación, ya que permitirán enfocar acciones de aprendizaje hacia los aspectos identificados en el estudio, en los que se detectaron las mayores dificultades.

Published
2022
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19. Alcohol and Cannabis Use Milestones in Diverse Urban Adolescents: Associations with Demographics, Parental Rule Setting, Sibling and Peer Deviancy, and Outcome Expectancies

Author

Amelia V. Wedel, Elisabeth P. Cabot, Michelle J. Zaso, and Aesoon Park

Subjects
Male, Parents, Health (social science), Adolescent, Alcohol Drinking, Ethanol, Substance-Related Disorders, Siblings, Public Health, Environmental and Occupational Health, Medicine (miscellaneous), Peer Group, Psychiatry and Mental health, Hallucinogens, Humans, Female, Cannabis, Demography
Published
2023

20. A survey of sodium absorption in 10 giant exoplanets with high-resolution transmission spectroscopy

Author

Adam B Langeveld, Nikku Madhusudhan, Samuel H C Cabot, Langeveld, AB [0000-0002-4451-1705], Madhusudhan, N [0000-0002-4869-000X], Cabot, SHC [0000-0001-9749-6150], and Apollo - University of Cambridge Repository

Subjects
planets and satellites: atmospheres, Space and Planetary Science, Astronomy and Astrophysics, methods: observational, techniques: spectroscopic, atmospheric effects, planets and satellites: gaseous planets
Abstract

The alkali metal sodium (Na) is one of the most commonly detected chemical species in the upper atmospheres of giant exoplanets. In this work we conducted a homogeneous survey of Na in a diverse sample of ten highly irradiated giant exoplanets using high-resolution transmission spectroscopy. Our sample includes nine planets with previous Na detections and one new detection. We confirm previous detections and assess multiple approaches for deriving Na line properties from high-resolution transmission spectra. The homogeneously measured sodium line depths were used to constrain the atmospheric heights ($H_{\text{Na}}$) with respect to the planetary radii ($R_{\text{p}}$). We assess an empirical trend describing the relative atmospheric height ($H_{\text{Na}}/R_{\text{p}}$) as a function of planetary equilibrium temperature ($T_{\text{eq}}$) and surface gravity ($g$), in which $H_{\text{Na}}/R_{\text{p}}$ decreases exponentially with $\xi \propto gT_{\text{eq}}$, approaching a constant at large $\xi$. We also report the sodium D2/D1 line ratios across our sample and find that seven targets have line ratios that are consistent with unity. Finally, we measured net blueshifted offsets of the sodium absorption lines from their rest frame wavelengths for all ten planets, corresponding to day-night wind velocities of a few km s$^{-1}$. This suggests that the broad sample of exoplanets share common underlying processes that govern atmospheric dynamics. Our study highlights a promising avenue for using high-resolution transmission spectroscopy to further our understanding of how atmospheric characteristics vary over a diverse sample of exoplanets.

Published
2023
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22. Increased Frailty Associated with Higher Long-Term Mortality after Major Lower Extremity Amputation

Author

Jade Cotton, John Cabot, Jacob Buckner, Alyssa Field, Lori Pounds, and Clay Quint

Subjects
Peripheral Vascular Diseases, Frailty, Frail Elderly, General Medicine, Risk Assessment, Amputation, Surgical, Postoperative Complications, Treatment Outcome, Lower Extremity, Risk Factors, Humans, Surgery, Cardiology and Cardiovascular Medicine, Aged, Retrospective Studies
Abstract

Frailty assessments have been incorporated into preoperative planning for surgery in the elderly population. Frailty in patients undergoing lower extremity amputation has been associated with increased short-term mortality. We compared 2 frailty scores, modified Frailty Index (mFI) and Risk Analysis Index (RAI), to evaluate the short- and long-term mortality stratified by frailty status after lower extremity amputation.A retrospective review at a single Veterans Affairs Medical Center was performed for all patients with peripheral vascular disease that underwent an above or below the knee amputation from 2014 to 2019. Preoperative variables were obtained to calculate the mFI and RAI frailty scores. The frailty scoring systems were used to separate the patients into 3 cohorts: non-frail (mFI0.45, RAI20), frail (mFI 0.45-0.55; RAI 20-32), and very frail (mFI0.55, RAI32). The frailty groups with each scoring system were compared for 30-day outcomes (readmission, reoperation, adverse events, length of stay) and short- and long-term mortality.A total of 298 patients underwent lower extremity amputation. The number of non-frail patients was 98 (RAI) and 102 (mFI); frail patients 99 (RAI), and 123 (mFI); very frail patients 101 (RAI) and 73 (mFI). For the 30-day outcomes, only length of stay (mFI) was associated with increasing frailty. The short- and long-term mortality was associated with a worse survival with increasing frailty. At 1-year, the mortality by RAI was non-frail 8%; frail 24%, very frail 43% (P 0.001); the mortality by mFI was non-frail 16%, frail 24%, very frail 41% (P 0.001).Preoperative frailty scoring systems identify patients with worse short- and long-term mortality for lower extremity amputation. Frailty scoring should be considered as a screening tool for patients with peripheral vascular disease undergoing lower extremity amputation because of the high rate of frail and very frail patients. The frailty status may provide a more patient-centered approach to counsel patients and their families on the risks and benefits of amputation.

Published
2022
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24. Predictability of pseudophakic refraction using patient-customized paraxial eye models

Author

Yu-Cherng Chang, Florence Cabot, Bianca Maceo Heilman, Larissa Meza, Marco Ruggeri, Arthur Ho, Sonia H. Yoo, Jean-Marie Parel, and Fabrice Manns

Subjects
Lenses, Intraocular, Optics and Photonics, Ophthalmology, Biometry, Phacoemulsification, Lens Implantation, Intraocular, Visual Acuity, Humans, Surgery, Prospective Studies, Refraction, Ocular, Sensory Systems, Retrospective Studies
Abstract

To determine whether patient-customized paraxial eye models that do not rely on exact ray tracing and do not consider aberrations can accurately predict pseudophakic refraction.Bascom Palmer Eye Institute, Miami, Florida.Prospective study.Cataract surgery patients with and without a history of refractive surgery were included. Manifest refraction, corneal biometry, and extended-depth optical coherence tomography (OCT) imaging were performed at least 1 month postoperatively. Corneal and OCT biometry were used to create paraxial eye models. The pseudophakic refraction simulated using the eye model was compared with measured refraction to calculate prediction error.49 eyes of 33 patients were analyzed, of which 12 eyes from 9 patients had previous refractive surgery. In eyes without a history of refractive surgery, the mean prediction error was 0.08 ± 0.33 diopters (D), ranging from -0.56 to 0.79 D, and the mean absolute error was 0.27 ± 0.21 D. 31 eyes were within ±0.5 D, and 36 eyes were within ±0.75 D. In eyes with previous refractive surgery, the mean prediction error was -0.44 ± 0.58 D, ranging from -1.42 to 0.32 D, and the mean absolute error was 0.56 ± 0.46 D. 7 of 12 eyes were within ±0.5 D, 8 within ±0.75 D, and 10 within ±1 D. All eyes were within ±1.5 D.Accurate calculation of refraction in postcataract surgery patients can be performed using paraxial optics. Measurement uncertainties in ocular biometry are a primary source of residual prediction error.

Published
2022
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25. Modeling should be an independent scientific discipline

Author

Jordi Cabot and Antonio Vallecillo

Subjects
Modeling and Simulation, Software
Abstract

Software modeling started as a paradigm to help developers build better software faster by enabling them to specify, reason and manipulate software systems at a higher-abstraction level while ignoring irrelevant low-level technical details. But this same principle manifests in any other domain that has to deal with complex systems, software-based or not. We argue that bringing to other engineering and scientific fields, our modeling expertise is a win–win opportunity where we can all learn from each other as we all model, but in complementary ways. Nevertheless, to fully unleash the benefits of this collaboration, we must go beyond individual efforts trying to adapt single techniques from one field to another. It requires a deeper reformulation of modeling as a whole. It is time for modeling to become an independent discipline where all fields of knowledge can contribute and benefit from.

Published
2022
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26. TOI-4010: A System of Three Large Short-Period Planets With a Massive Long-Period Companion

Author

Kunimoto, Michelle, Vanderburg, Andrew, Huang, Chelsea X., Davis, M. Ryleigh, Affer, Laura, Cameron, Andrew Collier, Charbonneau, David, Cosentino, Rosario, Damasso, Mario, Dumusque, Xavier, Fiorenzano, A. F. Martnez, Ghedina, Adriano, Haywood, R. D., Lienhard, Florian, López-Morales, Mercedes, Mayor, Michel, Pepe, Francesco, Pinamonti, Matteo, Poretti, Ennio, Maldonado, Jesús, Rice, Ken, Sozzetti, Alessandro, Wilson, Thomas G., Udry, Stéphane, Baptista, Jay, Barkaoui, Khalid, Becker, Juliette, Benni, Paul, Bieryla, Allyson, Bosch-Cabot, Pau, Ciardi, David R., Collins, Karen A., Collins, Kevin I., Evans, Elise, Dupuy, Trent J., Goliguzova, Maria V., Guerra, Pere, Kraus, Adam, Lissauer, Jack J., Huber, Daniel, Murgas, Felipe, Palle, Enric, Quinn, Samuel N., Safonov, Boris S., Schwarz, Richard P., Shporer, Avi, Stassun, Keivan G., Jenkins, Jon M., Latham, David W., Ricker, George R., Seager, Sara, Vanderspek, Roland, Winn, Joshua, Essack, Zahra, Lewis, Hannah M., Rose, Mark E., Kunimoto, M [0000-0001-9269-8060], Vanderburg, A [0000-0001-7246-5438], Huang, CX [0000-0003-0918-7484], Davis, MR [0000-0002-7451-4704], Affer, L [0000-0001-5600-3778], Cameron, AC [0000-0002-8863-7828], Charbonneau, D [0000-0002-9003-484X], Cosentino, R [0000-0003-1784-1431], Damasso, M [0000-0001-9984-4278], Dumusque, X [0000-0002-9332-2011], Fiorenzano, AFM [0000-0002-4272-4272], Ghedina, A [0000-0003-4702-5152], Haywood, RD [0000-0001-9140-3574], Lienhard, F [0000-0003-4047-0771], López-Morales, M [0000-0003-3204-8183], Mayor, M [0000-0002-9352-5935], Pepe, F [0000-0002-9815-773X], Pinamonti, M [0000-0002-4445-1845], Poretti, E [0000-0003-1200-0473], Maldonado, J [0000-0002-2218-5689], Rice, K [0000-0002-6379-9185], Sozzetti, A [0000-0002-7504-365X], Wilson, TG [0000-0001-8749-1962], Udry, S [0000-0001-7576-6236], Baptista, J [0000-0002-9306-1704], Barkaoui, K [0000-0003-1464-9276], Becker, J [0000-0002-7733-4522], Benni, P [0000-0001-6981-8722], Bieryla, A [0000-0001-6637-5401], Bosch-Cabot, P [0000-0002-1514-5558], Ciardi, DR [0000-0002-5741-3047], Collins, KA [0000-0001-6588-9574], Collins, KI [0000-0003-2781-3207], Dupuy, TJ [0000-0001-9823-1445], Goliguzova, MV [0000-0003-2228-7914], Guerra, P [0000-0002-4308-2339], Kraus, A [0000-0001-9811-568X], Lissauer, JJ [0000-0001-6513-1659], Huber, D [0000-0001-8832-4488], Murgas, F [0000-0001-9087-1245], Palle, E [0000-0003-0987-1593], Quinn, SN [0000-0002-8964-8377], Safonov, BS [0000-0003-1713-3208], Schwarz, RP [0000-0001-8227-1020], Shporer, A [0000-0002-1836-3120], Stassun, KG [0000-0002-3481-9052], Jenkins, JM [0000-0002-4715-9460], Latham, DW [0000-0001-9911-7388], Ricker, GR [0000-0003-2058-6662], Seager, S [0000-0002-6892-6948], Vanderspek, R [0000-0001-6763-6562], Winn, J [0000-0002-4265-047X], Essack, Z [0000-0002-2482-0180], Lewis, HM [0000-0002-7871-085X], Rose, ME [0000-0003-4724-745X], Apollo - University of Cambridge Repository, Science & Technology Facilities Council, University of St Andrews. School of Physics and Astronomy, and University of St Andrews. St Andrews Centre for Exoplanet Science

Subjects
MCC, Earth and Planetary Astrophysics (astro-ph.EP), Exoplanets, Exoplanet dynamics, FOS: Physical sciences, DAS, 5109 Space Sciences, Hot Neptunes, QB Astronomy, Transit photometry, Exoplanet systems, 51 Physical Sciences, Astrophysics - Earth and Planetary Astrophysics, QB
Abstract

We report the confirmation of three exoplanets transiting TOI-4010 (TIC-352682207), a metal-rich K dwarf observed by TESS in Sectors 24, 25, 52, and 58. We confirm these planets with HARPS-N radial velocity observations and measure their masses with 8 - 12% precision. TOI-4010 b is a sub-Neptune ($P = 1.3$ days, $R_{p} = 3.02_{-0.08}^{+0.08}~R_{\oplus}$, $M_{p} = 11.00_{-1.27}^{+1.29}~M_{\oplus}$) in the hot Neptune desert, and is one of the few such planets with known companions. Meanwhile, TOI-4010 c ($P = 5.4$ days, $R_{p} = 5.93_{-0.12}^{+0.11}~R_{\oplus}$, $M_{p} = 20.31_{-2.11}^{+2.13}~M_{\oplus}$) and TOI-4010 d ($P = 14.7$ days, $R_{p} = 6.18_{-0.14}^{+0.15}~R_{\oplus}$, $M_{p} = 38.15_{-3.22}^{+3.27}~M_{\oplus}$) are similarly-sized sub-Saturns on short-period orbits. Radial velocity observations also reveal a super-Jupiter-mass companion called TOI-4010 e in a long-period, eccentric orbit ($P \sim 762$ days and $e \sim 0.26$ based on available observations). TOI-4010 is one of the few systems with multiple short-period sub-Saturns to be discovered so far., Comment: 26 pages, 16 figures, published in AJ; (v3) added missing citation

Published
2023
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27. Cobalt–Iron Oxyhydroxide Obtained from the Metal Phosphide: A Highly Effective Electrocatalyst for the Oxygen Evolution Reaction at High Current Densities

Author

María Isabel Díez-García, Guillem Montaña-Mora, Marc Botifoll, Andreu Cabot, Jordi Arbiol, Mohammad Qamar, and Joan Ramon Morante

Subjects
Materials Chemistry, Electrochemistry, Energy Engineering and Power Technology, Chemical Engineering (miscellaneous), Electrical and Electronic Engineering
Published
2023
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29. Behavior of Constitutional Dynamic Networks: Competition, Selection, Self‐sorting in Cryptate Systems

Author

Artem Osypenko, Rafel Cabot, Joseph J. Armao, Petr Kovaříček, Antonio Santoro, Jean‐Marie Lehn, Lehn, Jean‐Marie [0000-0001-8981-4593], and Apollo - University of Cambridge Repository

Subjects
3403 Macromolecular and Materials Chemistry, 34 Chemical Sciences
Abstract

Understanding dynamic systems is a crucial step toward the design of complex matter. Here, we aim to study the behavior of Constitutional Dynamic Networks (CDNs) in conditions of dynamic competition, taking cryptands and metal cations as a test bed. The CDNs of cryptates were analyzed by NMR spectroscopy. The experimental results were complemented by extensive numerical simulations, based on a large amount of thermodynamic and kinetic data available in the literature for cryptates. Although the CDN′s output is a result of the interplay between the individual stability constants of the complexes in a mixture, the overall effect may be governed by only one – the most thermodynamically stable member of a network. Significantly, these findings indicate that an increase in complexity (multiplicity and connectivity) of a system may, in conditions of dynamic competition, result in “simplexity”, i. e. a simplification of the output of the system.

Published
2023
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32. Spin Effect to Promote Reaction Kinetics and Overall Performance of Lithium‐Sulfur Batteries under External Magnetic Field

Author

Chao Yue Zhang, Chaoqi Zhang, Guo Wen Sun, Jiang Long Pan, Li Gong, Geng Zhi Sun, Jordi Jacas Biendicho, Lluís Balcells, Xiao Long Fan, Joan Ramon Morante, Jin Yuan Zhou, Andreu Cabot, National Natural Science Foundation of China, Fundamental Research Funds for the Central Universities (China), China Scholarship Council, Ministerio de Ciencia, Innovación y Universidades (España), Zhang, Chao Yue, Zhang, Chaoqi, Sun, Guo Wen, Fan, Xiao Long, Zhou, Jin Yuan, and Cabot, Andreu

Subjects
Lithium-Sulfur Battery, Electrospinning, Lithium Polysulfide, General Chemistry, General Medicine, Spin Polarization, Cobalt Sulfides, Catalysis
Abstract

Lithium-sulfur batteries (LSBs) are still limited by the shuttle of lithium polysulfides (LiPS) and the slow Li-S reaction. Herein, we demonstrate that when using cobalt sulfide as a catalytic additive, an external magnetic field generated by a permanent magnet can significantly improve the LiPS adsorption ability and the Li-S reaction kinetics. More specifically, the results show both experimentally and theoretically how an electron spin polarization of Co ions reduces electron repulsion and enhances the degree of orbital hybridization, thus resulting in LSBs with unprecedented performance and stability. Under an external magnetic field, LSBs with 0.0084 % per cycle decay rate at 2 C during 8150 cycles are produced. Overall, this work not only demonstrates an effective strategy to promote LiPS adsorption and electrochemical conversion in LSBs at no additional energy cost but also enriches the application of the spin effect in the electrocatalysis fields., This work was supported by the National Natural Science Foundation of China (Grant Nos.: 51572118 and 21975123) and partially by the Fundamental Research Funds for the Central Universities (Grant Nos.: lzujbky-2021-it33). C. Y. Zhang, C. Q. Zhang, and L. Gong thank the China Scholarship Council for the scholarship support. A. Cabot thanks financial support from the Combenergy project (PID2019-105490RB-C32) from the Spanish Ministerio de Ciencia e Innovación. The authors also greatly acknowledge the support supported by the Supercomputing Center of Lanzhou University, China., With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000917-S).

Published
2022
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33. Activity of cefiderocol, imipenem/relebactam, cefepime/taniborbactam and cefepime/zidebactam against ceftolozane/tazobactam- and ceftazidime/avibactam-resistant Pseudomonas aeruginosa

Author

Cristina Lasarte-Monterrubio, Pablo Arturo Fraile-Ribot, Juan Carlos Vázquez-Ucha, Gabriel Cabot, Paula Guijarro-Sánchez, Isaac Alonso-García, Soraya Rumbo-Feal, Fátima Galán-Sánchez, Alejandro Beceiro, Jorge Arca-Suárez, Antonio Oliver, and Germán Bou

Subjects
Pharmacology, Microbiology (medical), Tazobactam, Carboxylic Acids, Ceftazidime, beta-Lactamases, Anti-Bacterial Agents, Cephalosporins, Cyclooctanes, Imipenem, Infectious Diseases, Piperidines, Pseudomonas aeruginosa, Humans, Pseudomonas Infections, Pharmacology (medical), Borinic Acids, Cefepime, Azabicyclo Compounds
Abstract

Objectives To evaluate the activity of cefiderocol, imipenem/relebactam, cefepime/taniborbactam and cefepime/zidebactam against a clinical and laboratory collection of ceftolozane/tazobactam- and ceftazidime/avibactam-resistant Pseudomonas aeruginosa β-lactamase mutants. Methods The activity of cefiderocol, imipenem/relebactam, cefepime/taniborbactam, cefepime/zidebactam and comparators was evaluated against a collection of 30 molecularly characterized ceftolozane/tazobactam- and/or ceftazidime/avibactam-resistant P. aeruginosa isolates from patients previously treated with cephalosporins. To evaluate how the different β-lactamases in the clinical isolates affected the resistance to these agents, a copy of each blaPDC, blaOXA-2 and blaOXA-10 ancestral and mutant allele from the clinical isolates was cloned in pUCp24 and expressed in dual blaPDC-oprD (for blaPDC-like genes) or single oprD (for blaOXA-2-like and blaOXA-10-like genes) PAO1 knockout mutants. MICs were determined using reference methodologies. Results For all isolates, MICs were higher than 4 and/or 8 mg/L for ceftolozane/tazobactam and ceftazidime/avibactam, respectively. Cefiderocol was the most active agent, showing activity against all isolates, except one clinical isolate that carried an R504C substitution in PBP3 (MIC = 16 mg/L). Imipenem/relebactam was highly active against all isolates, except two clinical isolates that carried the VIM-20 carbapenemase. Cefepime/zidebactam and cefepime/taniborbactam displayed activity against most of the isolates, but resistance was observed in some strains with PBP3 amino acid substitutions or that overexpressed mexAB-oprM or mexXY efflux pumps. Evaluation of transformants revealed that OXA-2 and OXA-10 extended-spectrum variants cause a 2-fold increase in the MIC of cefiderocol relative to parental enzymes. Conclusions Cefiderocol, imipenem/relebactam, cefepime/taniborbactam and cefepime/zidebactam show promising and complementary in vitro activity against ceftolozane/tazobactam- and ceftazidime/avibactam-resistant P. aeruginosa. These agents may represent potential therapeutic options for ceftolozane/tazobactam- and ceftazidime/avibactam-resistant P. aeruginosa infections.

Published
2022
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36. Surgical risk calculators in veterans following lower extremity amputation

Author

Jacob Buckner, John Cabot, Alyssa Fields, Lori Pounds, and Clay Quint

Subjects
Postoperative Complications, Lower Extremity, Risk Factors, Humans, Surgery, General Medicine, Risk Assessment, Amputation, Surgical, Retrospective Studies, Veterans
Abstract

To evaluate the accuracy of multiple risk calculators for 30-day mortality on patients undergoing major lower extremity amputation.The actual 30-day mortality at a single Veterans Affairs institution was compared to the predicted outcome from the following risk calculators: ACS-NSQIP, VASQIP, amputation scoring tool (AST), and POTTER elective.The overall calculated 30-day mortality was similar to the actual mortality with the VASQIP and POTTER elective risk calculators, while the NSQIP and AST over-estimated the 30-day mortality. The predictive accuracy of the POTTER and NSQIP risk calculators were moderate (AUC0.7), and fair for the VASQIP and AST.Risk assessment tools can provide adjunctive data on predicted 30-day mortality in patients undergoing major lower extremity amputation. In our study, there were differences in predictability of the risk calculators for lower extremity amputation that should be considered when utilizing a risk assessment tool to improve physician-patient shared decision-making.

Published
2022
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37. Utilisateurs et non-utilisateurs des centres d’aide en français au postsecondaire : une étude comparative par la méthode d’appariement cas-témoin

Author

Isabelle Cabot

Subjects
Education
Abstract

Devant le manque d’information formelle contribuant à cerner l’efficacité des centres d’aide disciplinaire au postsecondaire, on se questionne sur ce qui distingue les étudiants qui en utilisent les services de ceux qui ne les sollicitent pas. Dans l’objectif d’examiner l’efficacité potentielle de ces structures d’aide à la réussite, une exploration comparative des utilisateurs et des non-utilisateurs de centres d’aide en français (CAF) a été menée dans quatre établissements d’enseignement collégial. La méthode d’appariement cas-témoin a été appliquée de façon à optimiser le contrôle de six variables confondantes, déterminées par une analyse de régression linéaire. Ainsi, les analyses comparatives ont été conduites par des tests t pour groupes appariés. Les variables comparées touchent à la motivation relative aux services des CAF, à la peur du jugement négatif et à la performance aux cours de français. Les principaux résultats indiquent que les attentes d’intérêt suscitées par les activités déterminent la tendance à solliciter ceux-ci. Chez les utilisateurs, l’utilité attribuée aux services reçus est plus faible que celle à laquelle ils s’attendaient au départ. Néanmoins, à la fin du semestre, leurs performances aux cours de français sont plus élevées que celles de leurs pairs non-utilisateurs. Ces résultats sont discutés dans l’optique du besoin de rendre plus explicite l’efficacité des centres d’aide aux yeux des étudiants, et mènent à formuler des recommandations pra-tiques en ce sens. De nouvelles études devraient explorer l’efficacité de divers centres d’aide pédagogiques (disciplinaires ou multidisciplinaires) postsecondaires au Canada afin d’en optimiser le potentiel d’impact positif sur la réussite scolaire.

Published
2022
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41. Depletion of SMARCB1 and BRD7, two SWI/SNF chromatin remodelling complex subunits, differentially impact porcine embryo development

Author

Yu-Chun Tseng, Jennifer S. Crodian, and Ryan Cabot

Subjects
Chromosomal Proteins, Non-Histone, Swine, Embryonic Development, Chromatin Assembly and Disassembly, Chromatin, Endocrinology, Reproductive Medicine, Genetics, Animals, Animal Science and Zoology, Molecular Biology, Transcription Factors, Developmental Biology, Biotechnology
Abstract

Context SWI/SNF chromatin remodelling complexes are composed of multiple protein subunits and can be categorised into three sub-families, including the BAF, PBAF, and GBAF complexes. We hypothesised that depletion of SMARCB1 and BRD7, two subunits unique to different SWI/SNF sub-families, would differentially impact porcine embryo development. Aim The aim of these experiments was to determine the developmental requirements of two SWI/SNF subunits, SMARCB1 and BRD7. Methods RNA interference assays were used to determine the developmental requirements of SMARCB1 and BRD7 in porcine embryos. Key results Our findings indicate that knockdown of SMARCB1 dramatically reduces embryo developmental potential, with few embryos developing beyond the pronuclear stage. The knockdown of BRD7 had a less severe impact on developmental potential. Conclusions Our findings also demonstrate that knockdown of SMARCB1 alters the expression of NANOG and POU5F1 (also referred to as OCT4). Implications These findings highlight the unique developmental requirements for sub-families of SWI/SNF chromatin remodelling complexes. This new knowledge will enable us to determine how discrete genomic loci are differentially remodelled during key points in embryo development.

Published
2022
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42. Supplementary Appendix including cell line RRIDs and supplementary figures from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia

Author

Thomas P. Loughran, David J. Feith, Mark Kester, David F. Claxton, Myles C. Cabot, Hong-Gang Wang, Shantu Amin, Dhimant Desai, Gemma Fabrias, Jose Luis Abad, Todd E. Fox, Charyguly Annageldiyev, Arati Sharma, Su-Fern Tan, and Jennifer M. Pearson

Abstract

Figure S1. SACLAC reduces AC activity at lower doses than LCL204. Figure S2. SACLAC treatment increases production of multiple ceramide species in human AML cell lines. Figure S3. SACLAC is more toxic to AML cells than normal cells. Figure S4. SACLAC mechanism of action is consistent in multiple human AML cell lines. Figure S5. Exogenous ceramides induce apoptosis in human AML cell lines. Figure S6. AC knockdown alters splicing of Mcl-1 and Bim in HL-60/VCR cells via regulation of SF3B1. Figure S7. Baseline apoptosis varies based on type of electroporated content. Figure S8. Proposed model of SACLAC mechanism of action. Figure S9. IV administration of SACLAC improves delivery and lipids are shifted in mice.

Published
2023
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44. Figure S4 from Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile

Author

Marie-Odile Parat, David Sturgess, Kim-Anh Lê Cao, Carl M.J. Kirkpatrick, Paul N. Shaw, Peter J. Cabot, Zeyad D. Nassar, Kye Gregory, Tharindu Vithanage, Nicholas Matigian, and Nan Xie

Abstract

Relationship between cAMP measurements and morphine mouse administration, and in vitro morphine-spiked plasma concentration. Data was analysed with GraphPad Prism software (v. 7.00). A) Mice were treated with saline or morphine (1 or 10 mg/kg) and plasma samples were collected 10 min after intraperitoneal injection. cAMP production was determined by the AlphascreenTM assay. Graph shows morphine doses and cAMP production, for n=27 mice. B) 0.5 μL mouse plasma were spiked with indicated concentrations of morphine, and cAMP production by HEK-MOP cells was determined by the AlphascreenTM assay. Scatter plot shows in vitro morphine concentrations and cAMP production.

Published
2023
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45. Figure S1 from Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile

Author

Marie-Odile Parat, David Sturgess, Kim-Anh Lê Cao, Carl M.J. Kirkpatrick, Paul N. Shaw, Peter J. Cabot, Zeyad D. Nassar, Kye Gregory, Tharindu Vithanage, Nicholas Matigian, and Nan Xie

Abstract

Comparison of receptor activation potential between healthy subjects and preoperative patient samples. A) MOR activation was determined via HEK-MOP cAMP production by the AlphascreenTM assay using 5% (v/v) human plasma. B, C) HEK-Blue{trade mark, serif} hTLR4 cells were exposed to 5% (v/v) human plasma (B), or 5% (v/v) human plasma in the presence of 1 ng/mL LPS (C). SEAP activity was determined using QUANTI-Blue{trade mark, serif}. Data are shown as mean {plus minus} SEM, n=60 patients and 10 healthy participants, ****, p

Published
2023
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46. Figure S2 from Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile

Author

Marie-Odile Parat, David Sturgess, Kim-Anh Lê Cao, Carl M.J. Kirkpatrick, Paul N. Shaw, Peter J. Cabot, Zeyad D. Nassar, Kye Gregory, Tharindu Vithanage, Nicholas Matigian, and Nan Xie

Abstract

Correlation of cAMP production and LPS-induced TLR4 activation in morphine-treated mice. Mice were treated with saline or morphine (1 or 10 mg/kg) and plasma samples were collected 10 min after intraperitoneal injection. Production of cAMP by HEK-MOP cells was determined using the AlphascreenTM assay. HEK-Blue{trade mark, serif} hTLR4 cells were treated with 1 ng/mL LPS and 5% (v/v) mouse plasma, and the levels of SEAP were determined using QUANTI-Blue{trade mark, serif}. Scatter plot shows LPS-induced TLR4 activation and cAMP production for n=18 mice. Pair-wise correlation was assessed using the Pearson's method with GraphPad Prism software (v. 7.00).

Published
2023
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47. Figure S3 from Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile

Author

Marie-Odile Parat, David Sturgess, Kim-Anh Lê Cao, Carl M.J. Kirkpatrick, Paul N. Shaw, Peter J. Cabot, Zeyad D. Nassar, Kye Gregory, Tharindu Vithanage, Nicholas Matigian, and Nan Xie

Abstract

Comparison of proteolytic profile between healthy subjects and preoperative patient samples. MMP activity in samples was analysed using gelatine zymography (A) and TIMP activity was analysed using reverse zymography (B). Gels were scanned for densitometric quantitation. Data are shown as mean {plus minus} SEM, n=60 patients and 10 healthy participants, *, p

Published
2023
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48. Data from Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile

Author

Marie-Odile Parat, David Sturgess, Kim-Anh Lê Cao, Carl M.J. Kirkpatrick, Paul N. Shaw, Peter J. Cabot, Zeyad D. Nassar, Kye Gregory, Tharindu Vithanage, Nicholas Matigian, and Nan Xie

Abstract

Purpose: The purpose of this study is to investigate the potential interplay between opioid analgesia and tumor metastasis through modulation of μ-opioid receptor (MOR), Toll-like receptor 4 (TLR4) activation, and matrix degradation potential.Experimental Design: Plasma samples were collected from 60 patients undergoing elective lower limb joint replacement preoperatively and at 3, 6, and 24 hours after surgery; pain scores were documented at the same time points. Opioid administration was recorded and converted into morphine IV equivalents. Plasma samples were also collected from 10 healthy volunteers. Alphascreen cyclic AMP assay and MOR-overexpressing cells were employed to quantify MOR activation. HEK-Blue hTLR4 were utilized to measure TLR4 activation. Circulating matrix metalloprotease and tissue inhibitor of matrix protease activities were assessed by gelatin zymography and reverse zymography, respectively.Results: Postoperative plasma samples displayed the ability to activate MOR and to inhibit lipopolysaccharide (LPS)-induced TLR4 activation. Linear mixed model analysis revealed that MOR activation had a significant effect on inhibition of LPS-induced TLR4 activation. Furthermore, TLR4 had a significant effect to explain pain scores. Postoperative samples also displayed altered circulating matrix-degrading enzymes activity potential, but this was correlated neither to opioid administration nor to MOR activation potential.Conclusions: Our results show for the first time that (i) opioids administered to surgery patients result in modulation of ligand-induced TLR4 activation and (ii) postoperative pain is associated with increased circulating TLR4 activation potential. Our study further promotes the use of MOR activation potential rather than opioid intake in clinical studies measuring opioid exposure at a given time point. Clin Cancer Res; 24(10); 2319–27. ©2018 AACR.

Published
2023
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49. Selective Ethylene Glycol Oxidation to Formate on Nickel Selenide with Simultaneous Evolution of Hydrogen

Author

Junshan Li, Luming Li, Xingyu Ma, Xu Han, Congcong Xing, Xueqiang Qi, Ren He, Jordi Arbiol, Huiyan Pan, Jun Zhao, Jie Deng, Yu Zhang, Yaoyue Yang, and Andreu Cabot

Subjects
General Chemical Engineering, General Engineering, General Physics and Astronomy, Medicine (miscellaneous), General Materials Science, Biochemistry, Genetics and Molecular Biology (miscellaneous)
Published
2023
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50. Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Author

Rink-Jan Lohman, Karnaker Reddy Tupally, Ajit Kandale, Peter J. Cabot, and Harendra S. Parekh

Subjects
Pharmacology, Pharmacology (medical)
Abstract

Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit clinical translation. We modify endogenous dynorphin peptides to improve drug-likeness and develop safer KOP receptor agonists for clinical use. Using rational, iterative design, we developed a series of potent, selective, and metabolically stable peptides from dynorphin 1–7. Peptides were assessed for in vitro cAMP-modulation against three opioid receptors, metabolic stability, KOP receptor selectivity, desensitisation and pERK-signalling capability. Lead peptides were evaluated for in vivo efficacy in a rat model of inflammatory nociception. A library of peptides was synthesised and assessed for pharmacological and metabolic stability. Promising peptide candidates showed low nanomolar KOP receptor selectivity in cAMP assay, and improved plasma and trypsin stability. Selected peptides showed bias towards cAMP signalling over pERK activity, also demonstrating reduced desensitisation. In vivo, two peptides showed significant opioid-like antinociception comparable to morphine and U50844H. These highly potent and metabolically stable peptides are promising opioid analgesic leads for clinical translation. Since they are somewhat biased peptide Kappa agonists they may lack many significant side-effects, such as tolerance, addiction, sedation, and euphoria/dysphoria, common to opioid analgesics.

Published
2023
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