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Zinc oxide (ZnO) nanoparticles (NPs) have a wide range of biomedical applications. Present study demonstrates the new methodology in sol-gel technology for synthesizing Polyethylene glycol (PEG) ca ...

Background Patients with type 2 diabetes have higher rates of cardiovascular events. Among African Americans, there is a higher prevalence of both cardiovascular disease and type 2 diabetes. Few studies have examined longitudinally the change in glucose tolerance in younger adult African Americans. Methods To examine the longitudinal relationship of glucose tolerance with other cardiovascular risk factors, 30 African American men and women aged 20 to 43 years were examined twice at an interval of 4 to 5 years. Cardiovascular risk factors, glucose tolerance, and insulin sensitivity (determined from euglycemic hyperinsulinemic clamp procedure) were assessed at each examination. Known diabetics were excluded from initial enrollment. The relationship of glucose tolerance status (normal, impaired, or diabetic glucose tolerance) to body mass index, blood pressure, cholesterol, and insulin sensitivity were further investigated. Results Initial oral glucose tolerance test identified 24 of 130 (18.5%) subjects with impaired glucose tolerance and 2 of 130 (1.5%) subjects with diabetes. Of the remaining 104 subjects with normal glucose tolerance, subsequent 5-year examination detected 31 (29.8%) with impaired glucose tolerance and 5 (4.8%) with diabetes. Those who later developed diabetes had higher mean systolic blood pressure (133 versus 121, P = 0.037) at exam 1. By exam 2, those with abnormal glucose tolerance had worse cardiovascular risk profiles and increased insulin resistance ( P Conclusion Conversion to abnormal glucose tolerance is relatively frequent in young adult African Americans. Deterioration in glucose tolerance may be preceded by higher systolic blood pressure and is accompanied by worsening of other cardiovascular risk factors and insulin resistance.

Resume Les lesions hemispheriques droites (LHD) sont classiquement connues pour s'accompagner de troubles somatognosiques (TS) — souvent designes comme troubles du schema corporel (TSC) — unilateraux gauches. Ces TSC ≪classiques≫ sont en regle transitoires et ne peuvent expliquer les difficultes particulieres de la reeducation motrice des hemiplegies gauches. Ce travail preliminaire a pour objectifs: de rechercher l'existence de TS apres disparition d'eventuels TSC ≪classiques≫ initiaux; de verifier leur nature cognitive; de preciser le niveau du trouble en reference aux donnees recentes sur le schema corporel postural (SCP) et sur l'influence de l'heminegligence sur la proprioception. Neuf patients en reeducation pour hemiplegie gauche par AVC hemispherique droit unique et dix temoins apparies pour l'âge ont ete soumis a une batterie de tests d'imitation de postures et de mouvements. Les resultats font apparaitre une difference significative entre patients et temoins ( p ). Les causes d'echec sont un deficit sensitif important et la complexite des postures. Ces resultats s'accordent avec l'existence d'authentiques TS, pouvant concerner les deux hemicorps et qui ne seraient pas a proprement parler des TSC mais un deficit d'utilisation du SCP. Trois niveaux de traitement des informations d'origine proprioceptive sont envisages: niveau sensoriel elementaire, niveau perceptif, niveau constructif. Les implications pratiques sont discutees.

Intracranial haemorrhage is the most feared manifestation of haemophilia and is usually seen in severe forms. We report herein the case of a 66-year-old HIV-negative patient with mild haemophilia (factor VIII: 7%) who presented with a spontaneous and massive intracranial haematoma causing hemiplegia and aphasia. We discuss the management of this peculiar situation emphasizing the need for rapid and adapted FVIII replacement. A complete recovery was obtained using this strategy combined with initial resuscitation measures and subsequent physical therapy.

Intracranial haemorrhage is the most feared manifestation of haemophilia and is usually seen in severe forms. We report herein the case of a 66-year-old HIV-negative patient with mild haemophilia (factor VIII: 7%) who presented with a spontaneous and massive intracranial haematoma causing hemiplegia and aphasia. We discuss the management of this peculiar situation emphasizing the need for rapid and adapted FVIII replacement. A complete recovery was obtained using this strategy combined with initial resuscitation measures and subsequent physical therapy.

To examine the associations between the combination of obesity and tobacco use and total cardiovascular risk score in young adult African Americans.A cross-sectional study of 323 African-American men (N = 117) and women (N = 206) aged 20-46 years.Age, height, weight, and data on smoking behavior were obtained, as well as measurements of blood pressure, serum lipids, and measurements from an oral glucose tolerance test (OGTT). A cardiovascular risk score was calculated from the above data.Fasting insulin, fasting blood glucose, and blood glucose at 120 minutes of OGTT were significantly higher in obese (body mass index [BMI]or = 30 kg/m2) men. Obese men also had significantly higher LDL cholesterol, lower HDL cholesterol and higher total risk scores. Obese women had significantly higher blood pressure, higher fasting insulin, lower LDL cholesterol, and higher total risk scores. Among the members of this cohort, 65% of men and 79% of women were obese and/or smoked. Of those who were obese and/or smoked, 68% of the men and 82% of the women had at least one other cardiovascular risk factor.The modifiable risk factors of obesity and smoking were present in a large majority of these young adult African Americans in association with other cardiovascular risk factors.

800 mg of pentoxifylline 400 was administered daily to two groups of elderly patients (average age 80 years) with the aim of increasing cerebral efficiency. Fifty patients (Group I) were treated for 30 days and of these, 25 patients (Group II) were treated for a further, 60 days. The programme included a battery of psychometric tests (Rey's R.P.M. Recit of Barbizet, coupled image tests, immediate memory test) two geriatric scales (Geriatric Rating Scale and Nosie 30) and study of the deformability of red cells. Results at the 30th and 90th day were compared with pre-experimental results: corrected filterability was increased (Group I and II, P less than 0.05), memory tests showed significant improvement (Group I and II, P less than 0.005), geriatric rating scale showed no modification. There was no correlation between changes in corrected filterability and improvement in psychometric tests.

60 consecutive patients (mean age: 80,7 yrs; s.d.: 6,1 yrs; range 70-94 yrs) referred to a geriatric medicine department with syncope or dizziness were proposectively compared with 40 age and sex matched controls. A battery of non-invasive investigations including tilt-test, glycemia, 12 lead ecg., eeg, 24 hour ambulatory ecg recording,. M--mode echocardiogram and cervical Doppler velocimetry was applied blindly to patients and controls. The proportion of abnormalities was similar in both groups having sick sinus syndrom or complete atrio-ventricular block versus no control (p less than 0.05). By contrast history-case was of great predictive value: 6 of 13 patients reporting abrupt syncope had a 24 ecg recording showing sick sinus syndrom or complete atrio ventricular block, versus 2 of 47 other patients (p less than 0,01); 11 of 14 patients reporting orhostatic dizziness or syncope had a tilt-test consistent with orthostactic hypotension versus 6 of 46 other patients (p less than 0,01).

In order to interpret the physical processes resulting in plastic deformation in glasses, a physical model of deformation taking into account the anelastic and viscoplastic behaviour is used. Three physical parameters τ1, τ2, Nd are introduced and there is a good agreement between calculated and experimental curves. In addition, these parameters are determined in correlation with structural relaxation and with temperature.

A monomode carbon dioxide laser, delivering a constant power on any rotational line of either the 10.4-μ or the 9.4-μ band, has been achieved by control of the cavity frequency and of the gain. A piezoelectric ceramic has been used either for a frequency sweep of the cavity or for output stabilization at the bottom of the Lamb dip. This laser has been used for two studies.