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Introdução: Foi definido pela Organização Mundial da Saúde (OMS) em 2002, o cuidado paliativo comouma abordagem que proporciona qualidade de vida aos pacientes e sua família, frente a doenças que ameaçam a vida, entre elas podemos destacar o câncer. Os cuidados de enfermagem, juntamente com os cuidados paliativos éde grande importância para um bom tratamento e uma boa qualidade de vida para o paciente com o diagnóstico oncológico. Objetivo: Identificar os cuidados de enfermagem, prestados aos pacientes oncológicos em cuidados paliativos, identificar as principais intervenções de enfermagem ao paciente oncológico e sua família, e identificar intervenções de humanização do cuidado. Metodologia: Estudo de abordagem qualitativa, do tipo revisão integrativa da literatura, onde a construção se iniciou através da pergunta de pesquisa ‘’Quais as principais intervenções de enfermagem ao paciente oncológico em cuidados paliativos?’’. Resultados: Da utilização dos critérios de inclusão e exclusão, no total foram selecionados 7 artigos, entre os anos de 2017 e 2022, para compor este estudo, onde 3 artigos são da BDENF e 4 da LILACS. Quanto à metodologia empregada, houve predomínio de estudos com abordagem quantitativa (2) seguidos de qualitativos (4), revisão integrativa da literatura (1). Conclusão: Evidenciou-se a importância e as contribuições do profissional enfermeiro nos cuidados paliativos, a descrição desse profissional para a oferta de uma assistência adequada, humanizada e com qualidade, e a importância de uma comunicação de qualidade entre todos os envolvidos.

Hyperspectral and multispectral image fusion allows us to overcome the hardware limitations of hyperspectral imaging systems inherent to their lower spatial resolution. Nevertheless, existing algorithms usually fail to consider realistic image acquisition conditions. This paper presents a general imaging model that considers inter-image variability of data from heterogeneous sources and flexible image priors. The fusion problem is stated as an optimization problem in the maximum a posteriori framework. We introduce an original image fusion method that, on the one hand, solves the optimization problem accounting for inter-image variability with an iteratively reweighted scheme and, on the other hand, that leverages light-weight CNN-based networks to learn realistic image priors from data. In addition, we propose a zero-shot strategy to directly learn the image-specific prior of the latent images in an unsupervised manner. The performance of the algorithm is illustrated with real data subject to inter-image variability., Comment: IEEE Trans. Geosci. Remote sens., to be published. Manuscript submitted August 23, 2022; revised Dec. 15, 2022, and Mar. 13, 2023; and accepted Apr. 07, 2023

O presente artigo aborda o Estado Democrático de Direito, a partir de contextualização histórica de seu surgimento à concepção atual, que tem como sustentáculo, além das consagradas legalidade, isonomia e participação, a dignidade da pessoa humana. Nesse aspecto, verifica-se não há se falar em dignidade da pessoa humana sem sustentabilidade, já que o ser humano e o meio ambiente são inseparáveis. Em cotejo com a crise ambiental sem precedentes vivenciada, exsurge a necessidade de garantir o Estado Democrático de Direito, que só é atingido com a implementação da sustentabilidade, diante da insuficiência de conceitos outros como desenvolvimento sustentável.

Introduction: Health state valuation and diagnostic-therapeutic pathways at the junction between non-metastatic and metastatic castration-resistant prostate cancer (CRPC) are not well documented. We aimed at: (i) estimating the disability weights (DWs) for health states across a continuum of disease from asymptomatic non-metastatic (nmCRPC) to symptomatic metastatic state (mCRPC); (ii) mapping the diagnostic-therapeutic pathway of nmCRPC in Italy. Methods: Structured qualitative interviews were performed with clinical experts to gather information on nmCRPC clinical pathway. An online survey was administered to clinical experts to estimate DWs for four CRPC health states defined from interviews and literature review (i.e., nmCRPC, asymptomatic mCRPC, symptomatic mCRPC, mCRPC in progression during or after chemotherapy). Clinicians’ preferences for health states were elicited using the Person-Trade-Off (PTO) and Visual Analogue Scale (VAS) methods. DWs associated with each health state, from 0 (best imaginable health state) and 1 (worst imaginable health state), were estimated. Results: We found that the management of nmCRPC is heterogeneous across Italian regions and hospitals, especially with respect to diagnostic imaging techniques. DWs for PTO ranged from 0.415 (95% confidence interval [CI] 0.208-0.623) in nmCRPC to 0.740 (95% CI 0.560-0.920) in mCRPC, in progression during or after chemotherapy. DWs for VAS ranged between 0.246 (95% CI 0.131-0.361) in nmCRPC to 0.689 (95% CI 0.583-0.795) in mCRPC, in progression during or after chemotherapy. Conclusions: Estimated DWs suggest that delaying transition to a metastatic state might ease the disease burden at both patient and societal levels.

A Physalis angulata L. se desenvolve como planta silvestre nas zonas tropicais da América, sendo o seu centro de origem indeterminado. Objetivou-se avaliar diferentes doses de giberelina na germinação de sementes Physalis. A pesquisa foi realizada no laboratório de Sementes e propagação de plantas do Instituto Federal do Espírito Santo (IFES) – Campus Santa Teresa. Foram utilizadas 500 sementes de Physalis, distribuídas em delineamento inteiramente casualizado com 5 tratamentos e 4 repetições, sendo cada tratamento composto por 50 sementes imersas durante 30 minutos em água 26°C (testemunha), água com gelo (0°C), água fervente (100°C), geladeira (10°C) por 24 horas e congelador (-10°C) por 6 horas, conduzido em rolo de papel germitest, umedecido com água destilada na proporção de 2,5 vezes o peso do papel, armazenado em câmara de germinação tipo BOD, com temperatura de 25º C e luz controlada 12x12 horas. Após início de germinação e durante 30 dias, foram avaliados a porcentagem de germinação, o índice de velocidade de germinação e o tempo médio de germinação ao longo do período de germinação. Os tratamentos térmicos com Gelo (0°C), geladeira (10°C) por 24 horas e congelador (-10°C) por 6 horas apresentaram os melhores resultados para germinação, sendo que no tempo médio de germinação, o tratamento Congelador (-10°C), apresentou-se superior aos demais tratamentos com menor tempo médio de germinação. O tratamento térmico atuou de forma positiva para germinação de sementes de Physalis, sendo que o tratamento em congelador (-10°C), apresentou no geral, os melhores resultados.

A pesquisa foi realizada com o objetivo de avaliar diferentes doses de giberelina na emergência de plântulas de urucum e realizado no viveiro de mudas do Instituto Federal do Espírito Santo – Campus Santa Teresa, submetendo as sementes aos seguintes tratamentos: imersão por 30 minutos em: água (testemunha); solução de giberelina a 1.000 mg.L-1, 2.000 mg.L-1, 3.000 mg.L-1 e 4.000 mg.L-1. O delineamento experimental foi inteiramente casualizado (DIC), com 5 tratamentos e quatro repetições, com cada unidade experimental composto de 25 sementes, semeadas em tubetes de 280 mL. Após 30 dias do início da germinação, foi avaliada a porcentagem de emergência (E), índice de velocidade de germinação (IVE) e tempo médio de emergência (TME). O tratamento com giberelina na dosagem de 4.000 mg.L-1 apresentou o melhor resultado para emergência em plântulas de urucuzeiro, podendo este tratamento ser recomendado para esta espécie.

O substrato é importante na formação da muda, devendo apresentar condições adequadas à germinação e desenvolvimento do sistema radicular das plântulas. Objetivou-se, com este trabalho, avaliar a emergência de plântulas de tomate (Solanum lycopersicum) submetidas à diferentes doses de PROTAMIN GR. O experimento foi conduzido em viveiro instalado no setor de Fruticultura do Instituto Federal do Espirito Santo Campus Santa Teresa, ES. O delineamento experimental utilizado foi o de blocos casualizados, sendo composto por seis tratamentos de 25 plantas em quatro repetições, perfazendo 100 plantas por tratamento. Os tratamentos utilizados foram: Bioplant®; Bioplant® + 2% Protamin; Bioplant® + 4% Protamin; Bioplant® + 6% Protamin; Bioplant® + 8% Protamin e Bioplant® + 10% Protamin. Foram avaliados Emergência (E), Índice de Velocidade de Emergência (IVE) e Tempo médio de Emergência (TME). As mudas produzidas nas misturas com 4% de Protamin GR apresentaram melhor desempenho para emergência das plântulas. O uso deste fertilizante incorporados no substrato pode ser uma alternativa viável na produção de mudas de tomate.

Few extracts of plant species from the Brazilian flora have been validated from a pharmacological and clinical point of view, and it is important to determine whether their traditional use is proven by pharmacological effects. Cenostigma pluviosum var. peltophoroides is one of those plants, which belongs to the Fabaceae family that is widely used in traditional medicine and is very rich in tannins. Due to the lack of effective drugs to treat severe cases of Covid-19, the main protease of SARS-CoV-2 (Mpro) becomes an attractive target in the research for new antivirals since this enzyme is crucial for virus replication and does not have homologs in humans. This study aimed to prospect inhibitor candidates among the compounds from C. pluviosum extract, by virtual screening simulations using SARS-CoV-2 Mpro as target. Experimental validation was made by inhibitory proteolytic assays of recombinant Mpro and by antiviral activity with infected Vero cells. Docking simulations identify four compounds with potential inhibitory activity of Mpro present in the extract. The compound pentagalloylglucose showed the best result in proteolytic kinetics experiments, with suppression of recombinant Mpro activity by approximately 60%. However, in experiments with infected cells ethyl acetate fraction and sub-fractions, F2 and F4 of C. pluviosum extract performed better than pentagalloylglucose, reaching close to 100% of antiviral activity. The prominent activity of the extract fractions in infected cells may be a result of a synergistic effect from the different hydrolyzable tannins present, performing simultaneous action on Mpro and other targets from SARS-CoV-2 and host. Communicated by Ramaswamy H. Sarma

Made available in DSpace on 2022-04-28T17:23:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-04-06 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) UNIVATES Tobacco is a rich source of cellulosic material and one of the most cultivated non-food plants in the world with great potential for incorporation in polymeric matrices. The use of tobacco residues as reinforcing filler requires chemical/physical fiber treatment aiming to maximize compatibility with the polymer. In this study, tobacco residues were treated with two concentrations of NaOH (10 or 15 wt.%) at two-time exposures (3 or 5 h). Four distinct heating rates were used for each condition. It was applied an artificial neural network to model the thermogravimetric curves. After, the fitted ANN curves were used to create a 3D surface response. The equations from 3D surface response allowed the creation of thermogravimetric curves in any heating rate situated between the minimum and maximum range tested. Univ Caxias Sul, Programa Posgrad Engn Proc Tecnol PGEPROTEC, Rua Francisco Getulio Vargas, BR-1130 Caxias Do Sul, RS, Brazil Univ Vale Taquari UNIVATES, Ciencias Exatas & Engn, Av Avelino Talini 171, Lajeado, RS, Brazil Univ Fed Integracao LatinoAmer UNILA, Engn Mat, Foz Do Iguacu, Brazil Univ Estadual Paulista Unesp, Escola Engn, Dept Mat & Tecnol, Guaratingueta, SP, Brazil Univ Estadual Paulista Unesp, Escola Engn, Dept Mat & Tecnol, Guaratingueta, SP, Brazil

Cardiac rehabilitation (CR) is a class I recommendation after valvular surgery. Few data exist on the level of access to CR after surgical aortic valve replacement (SAVR), and the factors affecting the probability of timely access to CR after SAVR have never been empirically investigated. This study aims at estimating the proportion of SAVR patients who initiated timely CR and understanding to what extent timely access to CR for SAVR patients is influenced by specific characteristics of patients and hospitals.We conducted a real-world, retrospective, population-based study by identifying from the Italian National Hospital Discharge Records all the discharged alive SAVR patients who accessed timely CR from 2009-2016. Two different cutoffs for timely access were considered, i.e. one and 21 days after discharge. A unique dataset was constructed by merging several data sources. Multiple logistic regressions were performed to identify the factors influencing the probability to access to timely CR.107,545 patients underwent SAVR in Italy from 2009-2016 and were discharged alive. Overall, 71,593 SAVR patients (66.6%) accessed timely CR, with an increasing trend over time. Additional 6,149 patients (5.7%) started CR from 2-21 days after discharge, slightly decreasing over time. The probability of timely CR (one-day cutoff) was significantly higher in older (OR=1.025, p0.001) female patients (OR = 1.003, p0.05) and patients with cardiovascular and cerebrovascular comorbidities. Presence of rehabilitation wards and number of rehabilitation beds in the index hospital significantly increased the probability of timely access to CR (OR = 1.105, p0.001 and OR = 1.006, p0.001 respectively). Patients hospitalized in private teaching hospitals had the highest predicted probability of timely CR after SAVR. A substantial variation in access to CR was found across Italian regions. Similar results were obtained with the alternative 21-days cutoff.Approximately one-third of SAVR patients did not benefit from CR in Italy, mainly due to shortness of rehabilitation facilities, with relevant disparities across the country. The cessation of CR services during the COVID-19 pandemic provides the opportunity to re-think and innovate CR, shifting from center-based to home-based models. Digital health technologies can supplement traditional health services and grant safe, effective, and equitable access to care, especially for countries with insufficient rehabilitation bed capacity. As CR is associated with better outcomes, we recommend decision-makers to use our results to plan adequate healthcare services, also investing in digital health, to ensure patients' access to cost-effective care.

Este trabalho é fruto de discussões e aprendizados de duas pesquisadoras e de suas análises geográficas feministas. Tivemos como objetivo, discutir como a ciência geográfica, principalmente na área da saúde, necessita utilizar de metodologias feministas para compreender as iniquidades sociais, bem como os determinantes de saúdes, pois é a partir do olhar dessas teorias, como o conceito de interseccionalidade, que será passível de compreender as formas de opressão-dominação existentes na sociedade, pois é o alicerce do sistema patriarcal-capitalista-racista que determina desigualdades nos sujeitos sociais. Entendendo que para promovermos saúdes necessitamos dos feminismos, como luta, movimento social e metodologia, para que seja possível atingir o objetivo na busca de uma sociedade mais igualitária. Para isso, foram utilizados relatos orais, entrevistas e grupos focais realizadas pelas autoras nos trabalhos de monografia e dissertação de mestrado; o que contribui para a análise da interseccionalidades existentes entre as diferenças e semelhanças nas produções acadêmicas em que uma Geografia Feminista para a Saúde pode oferecer.

In many areas such as computational biology, finance or social sciences, knowledge of an underlying graph explaining the interactions between agents is of paramount importance but still challenging. Considering that these interactions may be based on nonlinear relationships adds further complexity to the topology inference problem. Among the latest methods that respond to this need is a topology inference one proposed by the authors, which estimates a possibly directed adjacency matrix in an online manner. Contrasting with previous approaches based on linear models, the considered model is able to explain nonlinear interactions between the agents in a network. The novelty in the considered method is the use of a derivative-reproducing property to enforce network sparsity, while reproducing kernels are used to model the nonlinear interactions. The aim of this paper is to present a thorough convergence analysis of this method. The analysis is proven to be sane both in the mean and mean square sense. In addition, stability conditions are devised to ensure the convergence of the analyzed method., 24 pages, 11 of which of which are supplementary material; 4 figures

The deaths caused by the covid-19 pandemic have recently decreased due to a worldwide effort in vaccination campaigns. However, even vaccinated people can develop a severe form of the disease that requires ICU admission. As a result, the search for antiviral drugs to treat these severe cases has become a necessity. In this context, natural products are an interesting alternative to synthetic medicines used in drug repositioning, as they have been consumed for a long time through traditional medicine. Many natural compounds found in plant extracts have already been shown to be effective in treating viral and bacterial diseases, making them possible hits to exploit against covid-19. The objective of this work was to evaluate the antiviral activity of different plant extracts available in the library of natural products of the Universidade Estadual de Maringá, by inhibiting the SARS-CoV-2 main protease (Mpro), and by preventing viral infection in a cellular model. As a result, the extract of Cytinus hypocistis, obtained by ultrasound, showed a Mpro inhibition capacity greater than 90%. In the infection model assays using Vero cells, an inhibition of 99.6% was observed, with a selectivity index of 42.7. The in silico molecular docking simulations using the extract compounds against Mpro, suggested Tellimagrandin II as the component of C. hypocistis extract most likely to inhibit the viral enzyme. These results demonstrate the potential of C. hypocistis extract as a promising source of natural compounds with antiviral activity against covid-19. Communicated by Ramaswamy H. Sarma

Semiconductor spin qubits have gained increasing attention as a possible platform to host a fault-tolerant quantum computer. First demonstrations of spin qubit arrays have been shown in a wide variety of semiconductor materials. The highest performance for spin qubit logic has been realized in silicon, but scaling silicon quantum dot arrays in two dimensions has proven to be challenging. By taking advantage of high-quality heterostructures and carefully designed gate patterns, we are able to form a tunnel coupled 2 $\times$ 2 quantum dot array in a $^{28}$Si/SiGe heterostructure. We are able to load a single electron in all four quantum dots, thus reaching the (1,1,1,1) charge state. Furthermore we characterise and control the tunnel coupling between all pairs of dots by measuring polarisation lines over a wide range of barrier gate voltages. Tunnel couplings can be tuned from about $30~\rm \mu eV$ up to approximately $400~\rm \mu eV$. These experiments provide a first step toward the operation of spin qubits in $^{28}$Si/SiGe quantum dots in two dimensions., Comment: 8 pages, 6 figures

Objectives The management of non-metastatic castration-resistant prostate cancer (nmCRPC) is rapidly evolving; however, little is known about the direct healthcare costs of nmCRPC. We aimed to estimate the cost-of-illness (COI) of nmCRPC from the Italian National Health Service perspective. Methods Structured, individual qualitative interviews were carried out with clinical experts to identify what healthcare resources are consumed in clinical practice. To collect quantitative estimates of healthcare resource consumption, a structured expert elicitation was performed with clinical experts using a modified version of a previously validated interactive Excel-based tool, EXPLICIT (EXPert eLICItation Tool). For each parameter, experts were asked to provide the lowest, highest, and most likely value. Deterministic and probabilistic sensitivity analyses (PSA) were carried out to test the robustness of the results. Results Ten clinical experts were interviewed, and six of them participated in the expert elicitation exercise. According to the most likely estimate, the yearly cost per nmCRPC patient is €4,710 (range, €2,243 to €8,243). Diagnostic imaging (i.e., number/type of PET scans performed) had the highest impact on cost. The PSA showed a 50 percent chance for the yearly cost per nmCRPC patient to be within €5,048 using a triangular distribution for parameters, and similar results were found using a beta-PERT distribution. Conclusions This study estimated the direct healthcare costs of nmCRPC in Italy based on a mixed-methods approach. Delaying metastases may be a reasonable goal also from an economic standpoint. These findings can inform decision-making about treatments at the juncture between non-metastatic and metastatic prostate cancer disease.

Plants of the Calea genus have been reported to contain lipophilic compounds, such as sesquiterpene lactones, with cytotoxic effect against different cancer cell lines. The aim of this manuscript was to investigate the chemical profile and cytotoxic activity of different fractions from Calea phylolepis leaves on different human cancer cell lines. The fractions were prepared using solvent extraction of increasing polarity, yielding hexane, ethyl acetate and methanolic fractions. All fractions were chemically analysed by thin layer chromatography (TLC), and their cytotoxic activity against HT-29 (colon adenocarcinoma), MCF-7 (breast cancer), U-251MG (malignant glioblastoma) and L929 (mouse fibroblast) cell lines was investigated. Among these, the hexane and ethyl acetate fractions showed higher cytotoxic effects, while the methanolic fraction did not show any cytotoxic effects. The major bioactive compound from the hexane fraction (12.15%) was isolated using chromatographic methods and was identified by nuclear magnetic resonance spectroscopy (NMR) and gas chromatography-mass spectrometry (GC-MS) analysis as 6-epi-β-verbesinol coumarate. This compound showed activity against breast cancer cells (IC50 = 5.8 ± 1.0 μg/ml), similar to etoposide. Furthermore, 6-epi-β-verbesinol coumarate showed low cytotoxicity to normal fibroblast cells, suggesting a high selectivity index (SI = 7.39) against breast cancer cells.

The aim of this work was to evaluate the influence of the use of coupling agent (CA) on the properties of thermoplastic composites produced from post-consumer polypropylene (rPP) and malt bagasse fibers (MB) of brewing industry. The CA used was maleic anhydride graft polypropylene copolymer (MAgPP). The study was carried out in two stages: in first step the best concentration of MB fibers was verified, where was varied the fiber contents between 0, 10, 20 and 30% (w/w); in the second step, the best MB concentration evaluated was used with different CA concentrations (0, 1, 3, 5 and 7% w/w). Of the three MB concentrations evaluated as reinforcing filler, the sample with a 30% (w/w) ratio presented 44% lower deformation than the others, presenting better mechanical resistance, although it also presented the highest water absorption. Thus, the 30% MB fiber content was chosen for two step, where the results showed that the PP/MB-30 composite treated with 3% (w/w) CA had a modulus of elasticity 10.3% higher than the same composite without CA, corroborating with the morphological analysis, which indicated better interfacial adhesion between composite components when CA was used. The PP/MB-30 composite treated with 1% (w/w) CA showed the highest thermal stability among all samples.

The work presents a methodology for assessing the safety of electrical system designs for non-conventional nuclear facilities in shutdown. The methodology adopts the core damage frequency as the main risk measure to assess the different architectures of power systems in a non-conventional nuclear facility. Among the reasons is the absence of a specific regulatory basis for this type of installation. The adoption of standards for nuclear power plants by non-conventional nuclear facilities does not take into account the functional and operational particularities of these installations, imposing criteria that are often overestimated, which can even lead to an increase in the financial risk for carrying out the projects. Safety probabilistic analyzes become essential tools for the facilities design and licensing. The modeling and quantification of systems failures in charge of ensuring the nuclear safety of non-conventional nuclear facilities are carried out in the CAFTA software environment. In these studies, the analysis of electrical system configurations and their influence on the overall risk of the installation stand out.

In general terms, safety demonstration of nuclear installations is carried out through an assessment of compliance with design criteria and safety requirements established in national and international codes and standards applicable to each type of installation. In addition, a safety analysis consisting of installation behavior study during its useful lifetime, shall be developed considering normal operating conditions, transients, and postulated accidents, to determine safety margins and verify the adequacy of items designed to prevent accidents or mitigate their consequences. Also, design requirements applicable to each installation item depend on its classification with respect to safety. Thus, safety classification of structures, systems, and components (SSCs) must be performed based on adequate methods and clear and consistent criteria to ensure that an overall safety level expected for the installation is achieved. It is worth emphasizing the importance of the terminology adopted and the understanding of concepts definitions used in a safety classification process. The objective of this paper is to present a review of the application of “safety related item” and “item important to safety” terminology, evaluating definitions and interpretations given by the International Atomic Energy Agency (IAEA), the United States Nuclear Regulatory Commission (U.S.NRC) and the National Nuclear Energy Commission (CNEN) of Brazil. In this work, this subject is raised to demonstrate that divergent definitions and misinterpretations of concepts may result in inconsistencies in SSCs safety classification.

The nuclear licensing process is a fundamental stage for the design and deployment of a nuclear facility. In Brazil, the licensing process of Central Nuclear Almirante Álvaro Alberto (CNAAA) nuclear power plants, in Angra dos Reis - RJ, was established mainly based on the U.S. Nuclear Regulatory Commission (U.S.NRC) guidelines. However, for each purpose specific requirements are established which promote a standardisation appropriate to the type of installation in question. Thus, not every nuclear installation can be adequately framed in the standards and requirements established for the licensing of a nuclear power plant, especially when considering nuclear facilities for strategic and defense purposes. For instance, the Specialized Maintenance Complex (CME) project that is being developed by the Brazilian Navy and aims to offer all the structure and systems for support on land to the first Brazilian nuclear-powered submarine. Therefore, when considering the interfaces between maritime/naval systems and operations, the purpose and specificity of installations such as CME extrapolate the commonly established nuclear normative framework. Due to the innovation of this type of installation in Brazil, there is no specific regulation for its licensing, constituting a unique situation for both the Brazilian Navy (applicant) and the National Nuclear Energy Commission - CNEN (Brazilian Nuclear Licensing Agency, which, in the near future, will have its function incorporated into the National Nuclear Safety Authority, ANSN). Even when researching standards and other guides in ostensible sources of nations that holds nuclear reactor technology for naval propulsion (and land support facilities), no normative guidance dealing specifically with the safety analysis and licensing of this type of installation has been identified. Thus, this paper proposes a first approach and analysis of the standards used by the U.S. Department of Defense (U.S.DOE) comparing them to the standards of the U.S. Nuclear Regulatory Commission (U.S.NRC) aiming to compose a specific normative proposition to carry out the safety analysis and licensing of a nuclear-powered submarines land support facility.

O presente artigo versa sobre a proteção de dados pessoais diante dos complexos desafios, destinando-se seu enfoque a proteção de dados e ao direito à privacidade, presentes na atual constituição. Sabe-se que umas das características dos direitos fundamentais são o seu semblante não absoluto, proporcionando, de tal maneira, divergências entre tais direitos. Nesse contexto, a análise do artigo 5º incisos IV, X, XXXIII da Constituição Federal, está diante de um conflito constitucional, tendo em vista a liberdade de pensamento e a violação da privacidade, trazendo consigo a vida privada. Necessário considerar que tais direitos são um exemplo clássico da colisão dos direitos fundamentais, ressalta-se dessa forma a importância da liberdade de pensamento em conjunto com o direito à informação. A globalização é peça fundamental deste esquema, visto que, a difusão da informação atualmente é dada de forma imediata, relevando acontecimento a uma velocidade quase instantânea. Em contrapartida, o direito à privacidade se faz, mas que necessário, tendo em vista como base fundamental a Constituição Federal em seu inciso X, e juntamente com o novo código civil, Lei 10.406/02 em seus artigos 11 ao 21 bem como a Lei 13.709, que trata da Proteção de Dados. Analisando-se a pertinência destes conflitos, faz mister a utilização de um meio eficaz e alternativos para correção. Assim sendo, a problemática sobre a qual se desdobrará a análise é a respeito dos desafios destinados a proteção de dados e ao direito a privacidade tendo em vista também um olhar sobre o viés da tutela penal a respeito do presente tema, possuindo como base doutrinas modernas, revistas jurídicas e sites remetentes ao conteúdo. Bem como planeja analisar pontos da Constituição Federal, do Código Civil e Código Penal, em conjunto com leis referentes às infrações e suas atualizações.

Few extracts of plant species from the Brazilian flora have been validated from a pharmacological and clinical point of view, and it is important to determine whether their traditional use is proven by pharmacological effects.

We systematically study three-terminal InSb-Al nanowire devices by using radio-frequency reflectometry. Tunneling spectroscopy measurements on both ends of the hybrid nanowires are performed while systematically varying the chemical potential, magnetic field and junction transparencies. Identifying the lowest-energy state allows for the construction of lowest- and zero-energy state diagrams, which show how the states evolve as a function of the aforementioned parameters. Importantly, comparing the diagrams taken for each end of the hybrids enables the identification of states which do not coexist simultaneously, ruling out a significant amount of the parameter space as candidates for a topological phase. Furthermore, altering junction transparencies filters out zero-energy states sensitive to a local gate potential. Such a measurement strategy significantly reduces the time necessary to identify a potential topological phase and minimizes the risk of falsely recognizing trivial bound states as Majorana zero modes., Main text: 12 pages, 9 figures. SupplementaryMaterials: 12 pages, 14 figures

Este trabalho apresenta uma metodologia para avaliação de segurança de projetos de sistemas elétricos de instalações nucleares. A metodologia adota a frequência de dano ao núcleo como principal medida de risco para avaliar as diferentes arquiteturas dos sistemas de energia elétrica de uma instalação nuclear, subsidiando a seleção do projeto e o licenciamento destas instalações. Entre as motivações do trabalho está a ausência de uma base normativa que seja específica para o projeto de instalações nucleares que diferem das usinas nucleares de potência convencionais. A adoção de normas de usinas nucleares de potência para aplicação em outros tipos de instalações nucleares, nomeadas não convencionais, não leva em consideração suas particularidades funcionais e operacionais, impondo critérios muitas vezes superestimados, que podem acarretar, inclusive, em um aumento do risco financeiro para execução dos projetos. Nestes casos, análises probabilísticas de segurança tornam-se ferramentas imprescindíveis para o projeto e o licenciamento destas instalações nucleares. Como estudo de caso, considerou-se uma instalação nuclear não convencional com aplicações navais em que foram realizadas, no ambiente do software CAFTA, modelagens e quantificações das falhas dos sistemas responsáveis por garantir a segurança nuclear dessa instalação em modo de desligamento, durante uma parada para troca de combustíveis. Destaca-se neste estudo uma análise comparativa das possíveis configurações dos sistemas elétricos e a influência destas para o risco global da instalação. Como resultado, em função das particularidades funcionais, recomenda-se a revisão da base normativa das instalações nucleares não convencionais com aplicações navais. This work presents a methodology for safety assessing of electric power systems design in nuclear installations. The methodology adopts core damage frequency as the main risk measure to evaluate distinct configurations of electric power systems of a nuclear installation, subsidizing design selection and installation licensing. One of the motivations of this work is the lack of a normative basis specific to the design of nuclear facilities that differ from conventional nuclear power plants design basis. Functional and operational particularities of non-conventional nuclear facilities tend not to be considered when conventional standards are adopted in the normative basis, leading to the application of criteria that are often overestimated and resulting in an increase in the financial risk of project deployment. In these cases, probabilistic safety analyses may be essential tools for the design and licensing of nuclear facilities. As a case study, the analysis of a non-conventional nuclear installation with naval applications was performed using CAFTA software, and modeling and quantification of safety systems failures in plant shutdown mode during the refueling outage were carried out. This study highlights the comparative analysis of possible configurations of electrical systems and their impact on the overall installation risk. As a result, it is recommended to review the normative basis in terms of the functional particularities of non-conventional nuclear installations with naval applications.

Differing contexts have greatly influenced HTA development in various countries, with considerable effort recently made by international HTA networks (e.g., EUnetHTA) and the European Union (EU) to make HTA a more coherent, equal, and efficient process. Medical devices (MDs) present particular challenges for HTA because of frequent, rapid innovation, outcomes influenced by end-user competence, dynamic pricing and often low-quality scientific evidence. Our objective is to describe the development, structure and governance of a National HTA Program for MDs (PNHTADM) in Italy, a highly participatory, stakeholder-engaged, evidence-based process to reform a fragmented system of appraisal and approval. Based largely on EUnetHTA methods, the resulting process delineates a standardized system for proposing MDs by any stakeholders, accrediting HTA producers, setting criteria for prioritization and appraisals, and innovatively linking recommendations with coverage, reimbursement and procurement of MDs. Expected benefits include reduced disparities in pricing and reimbursement policies and improved access to new technologies across 21 regional healthcare systems in Italy's decentralized, universal system, complete with provisions to require additional evidence collection and centrally monitor diffusion. Though devised for Italy, the design, resources and underlying analysis provide a framework for other nations seeking to consolidate HTA initiatives, particularly in light of new EU regulation.

Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis (Mtb). In addition, the emergence of drug-resistant TB strains has exacerbated even further the treatment outcome of TB patients. It is thus needed the search for new therapeutic strategies to improve the current treatment and to circumvent the resistance mechanisms of Mtb. The shikimate kinase (SK) is the fifth enzyme of the shikimate pathway, which is essential for the survival of Mtb. The shikimate pathway is absent in humans, thereby indicating SK as an attractive target for the development of anti-TB drugs. In this work, a combination of in silico and in vitro techniques was used to identify potential inhibitors for SK from Mtb (MtSK). All compounds of our in-house database (Centro de Pesquisas em Biologia Molecular e Funcional, CPBMF) were submitted to in silico toxicity analysis to evaluate the risk of hepatotoxicity. Docking experiments were performed to identify the potential inhibitors of MtSK according to the predicted binding energy. In vitro inhibitory activity of MtSK-catalyzed chemical reaction at a single compound concentration was assessed. Minimum inhibitory concentration values for in vitro growth of pan-sensitive Mtb H37Rv strain were also determined. The mixed approach implemented in this work was able to identify five compounds that inhibit both MtSK and the in vitro growth of Mtb.

Chronic Non-Communicable Diseases (NCDs) have been considered a global health problem, characterized as diseases of multiple factors, which are developed throughout life, and regardless of genetics as a risk factor of important relevance, the increase in mortality attributed to the disease to environmental factors and the lifestyle one leads. Although the reactive species (ROS/RNS) are necessary for several physiological processes, their overproduction is directly related to the pathogenesis and aggravation of NCDs. In contrast, dietary polyphenols have been widely associated with minimizing oxidative stress and inflammation. In addition to their antioxidant power, polyphenols have also drawn attention for being able to modulate both gene expression and modify epigenetic alterations, suggesting an essential involvement in the prevention and/or development of some pathologies. Therefore, this review briefly explained the mechanisms in the development of some NCDs, followed by a summary of some evidence related to the interaction of polyphenols in oxidative stress, as well as the modulation of epigenetic mechanisms involved in the management of NCDs.

Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)acetamides was synthesized and evaluated as

International audience; Coupled tensor approximation has recently emerged as a promising approach for the fusion of hyperspectral and multispectral images, reconciling state of the art performance with strong theoretical guarantees. However, tensor-based approaches previously proposed assume that the different observed images are acquired under exactly the same conditions. A recent work proposed to accommodate inter-image spectral variability in the image fusion problem using a matrix factorization-based formulation, but did not account for spatially-localized variations. Moreover, it lacks theoretical guarantees and has a high associated computational complexity. In this paper, we consider the image fusion problem while accounting for both spatially and spectrally localized changes in an additive model. We first study how the general identifiability of the model is impacted by the presence of such changes. Then, assuming that the high-resolution image and the variation factors admit a Tucker decomposition, two new algorithms are proposed-one purely algebraic, and another based on an optimization procedure. Theoretical guarantees for the exact recovery of the high-resolution image are provided for both algorithms. Experimental results show that the proposed method outperforms state-of-the-art methods in the presence of spectral and spatial variations between the images, at a smaller computational cost.

La cama es un componente esencial en la producción de aves de corral, ya que habitan sobre este material la mayor parte de su ciclo productivo, por consiguiente, en ella se puede encontrar heces, bacterias entéricas, patógenos de importancia zoonótica y/o de transmisión alimentaria, plaguicidas y antimicrobianos, los cuales pueden afectar la sanidad de las aves. Después del ciclo de producción avícola, la cama es comúnmente utilizada como fertilizante orgánico para mejorar la calidad de los suelos y los cultivos. A pesar de su amplio uso en la avicultura y agricultura, se conoce poco acerca de su importancia en la seguridad alimentaria, por lo cual, la presente revisión discute acerca de los patógenos y contaminantes presentes en la cama y sus riesgos para la seguridad alimentaria, además las prácticas de manejo y tratamientos más adecuados. Información que será útil para maximizar los usos de la cama y los desechos avícolas, para que estos no representen un peligro para las personas, animales y el medio ambiente.

There is no doubt that nanotechnology and nanoscience open new doors to new applications and products that can potentially revolutionize the practice field and how we conserve built heritage materials. However, we are living at the beginning of this era and the potential benefits of nanotechnology to specific conservation practice needs are not always fully understood. This opinion/review paper aims to present reflections and answer a question that we are often asked when working directly with stone field conservators: why should we use a nanomaterial instead of a conventional product? Why does size matter? To answer this question, we revise the basic concepts of nanoscience with implications for the built heritage conservation field.

Araticum (Annona crassiflora Mart.) is a native and endemic species to Brazilian Cerrado whose fruits have high sensorial, nutritional, bioactive, and economic potential. Its use in local folk medicine, associated with recent scientific findings, has attracted growing interest from different industrial sectors. Therefore, understanding the scientific advances achieved so far and identifying gaps to be filled is essential to direct future studies and transform accumulated knowledge into innovative technologies and products. In this review, we summarize the phytochemical composition, bioactivities, and food products from araticum fruit that have been reported in the scientific literature over the past 10 years. The compiled data showed that araticum fruit parts contain a wide range of bioactive compounds, particularly phenolic compounds, alkaloids, annonaceous acetogenins, carotenoids, phytosterols, and tocols. These phytochemicals contribute to different biological activities verified in araticum fruit extracts/fractions, including antioxidant, anti-inflammatory, anti-Alzheimer, anticancer, antidiabetic, anti-obesity, antidyslipidemic, antinociceptive, hepatoprotective, healing of the cutaneous wound, antibacterial, and insecticide effects. Despite the promising findings, further studies—particularly toxicological (especially, with byproducts), pre-clinical, and clinical trials—must be conducted to confirm these biological effects in humans and assure the safety and well-being of consumers.

As sementes em geral possuem um período determinado para germinação e após este tempo passam a não serem viáveis para plantio. A giberelina é um hormônio que atua estimulando a germinação em sementes que apresentem algum bloqueio para germinar. Objetivou-se avaliar o efeito da giberelina na emergência e desenvolvimento inicial de plântulas de mamoeiro cultivar golden, com sementes de diferentes idades. Os tratamentos foram sementes com um ano, dois anos e 3 anos, armazenadas em geladeira (10°C). Duzentas sementes de cada idade foram imersas durante 60 minutos em solução de Giberelina ( , na dosagem de 2000 mg.L-1, e 200 de cada idade em água pura como testemunha, e semeadas em bandejas com substrato comercial. Após trinta dias do início da emergência, foi avaliado a porcentagem de emergência, o índice de velocidade de emergência e o tempo médio de emergência. Sessenta dias após o início da emergência foram avaliadas a altura da planta, número de folhas, diâmetro do coleto, comprimento da raiz, massa verde e seca das folhas e das raízes. Sementes de mamão armazenadas por até três anos germinam normalmente e possuem potencial para emergência quando submetidas a tratamento pré germinativo com giberelina.

O estudo do substrato adequado é de grande importância na produção da muda para implantação de um pomar produtivo, pois fornece condições ideais para a germinação e desenvolvimento. Objetivou-se avaliar o efeito de diferentes substratos minerais na emergência e desenvolvimento inicial de plântulas de mamoeiro cultivar aliança. O experimento foi realizado em delineamento em blocos casualizados, com cinco tratamentos e quatro repetições. Foram utilizadas cinquenta sementes por repetição, e para cada avaliação foram consideradas cinco plantas de cada repetição. Os tratamentos utilizados foram compostos de terra pura, areia, perlita, vermiculita, todos na mistura de 3:1 e substrato comercial como testemunha. Após trinta dias do início da emergência foi avaliado a porcentagem de emergência, índice de velocidade de emergência e tempo médio de emergência. Noventa dias após o início da emergência foram avaliadas altura da planta, número de folhas, diâmetro do coleto, comprimento da raiz, massa verde e seca das folhas e das raízes. O substrato vermiculita apresentou os melhores desempenhos para emergência e desenvolvimento inicial de plântulas de mamoeiro CV aliança.

This Special Issue examines the synthesis, characterization, and manufacturing of nanoparticles and their potential advantages and applications for the conservation of built cultural heritage materials [...]