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1. What a single electroencephalographic (EEG) channel can tell us about patients with dementia due to Alzheimer's disease

Author

Del Percio, Claudio, Noce, Giuseppe, Lopez, Susanna, Tucci, Federico, Carlin, Graziano, Lizio, Roberta, Musat, Andreea M., Soricelli, Andrea, Salvatore, Marco, Ferri, Raffaele, Nobili, Flavio, Arnaldi, Dario, Famà, Francesco, Buttinelli, Carla, Giubilei, Franco, Marizzoni, Moira, Güntekin, Bahar, Yener, Görsev, Stocchi, Fabrizio, Vacca, Laura, Frisoni, Giovanni B., and Babiloni, Claudio

Subjects
Cerebral Cortex, Rest, General Neuroscience, Electroencephalography, Classification, Bipolar rsEEG Spectral Power Density, Neuropsychology and Physiological Psychology, Resting State Electroencephalographic (rsEEG) Rhythms, Alzheimer Disease, Physiology (medical), Telemonitoring and Prevention, Humans, Wakefulness, Dementia Due to Alzheimer's Disease (ADD), Aged
Abstract

Abnormalities in cortical sources of resting-state eyes-closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10–20 electrode montage) with 19 scalp electrodes provide useful markers of neurophysiological dysfunctions in the vigilance regulation in patients with Alzheimer's disease dementia (ADD). Here we tested whether these markers may be effective from a few scalp electrodes towards the use of low-cost recording devices. Clinical and rsEEG data acquired in hospital settings (10–20 electrode montage) from 88 ADD participants and 68 age-, education-, and sex-matched normal elderly controls (Nold) were available in an international Eurasian database. Standard spectral FFT analysis of rsEEG data for individual delta, theta, and alpha frequency bands was from C3-P3, C4-P4, P3-O1, and P4-O2 bipolar channels. As compared to the Nold group, the ADD group showed increased delta, theta, low-frequency alpha power density and decreased high-frequency alpha power density at all those bipolar channels. The highest classification accuracy between the ADD and Nold individuals reached 90 % (area under the receiver operating characteristic curve) using Alpha2/Theta power density computed at the C3-P3 bipolar channel. Standard rsEEG power density computed from a few posterior bipolar channels successfully classified Nold and ADD individuals, thus encouraging a massive prescreening of neurophysiological mechanisms underpinning the vigilance dysregulation in underserved old seniors. Ministero della Salute

Published
2022
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4. Prediction of cognitive worsening in de novo Parkinson's disease: Clinical use of biomarkers

Author

Arnaldi, Dario, De Carli, Fabrizio, Famà, Francesco, Brugnolo, Andrea, Girtler, Nicola, Picco, Agnese, Pardini, Matteo, Accardo, Jennifer, Proietti, Luca, Massa, Federico, Bauckneht, Matteo, Morbelli, Silvia, Sambuceti, Gianmario, and Nobili, Flavio

Subjects
cognition, Male, Tomography, Emission-Computed, Single-Photon, Parkinson's disease, 123I-FP-CIT-SPECT, Electroencephalography, Parkinson Disease, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Statistics, Nonparametric, Logistic Models, ROC Curve, Predictive Value of Tests, Humans, Female, EEG, Longitudinal Studies, Cognition Disorders, dementia, Aged, Tropanes
Abstract

Cognitive impairment is a frequent and disabling feature of Parkinson's disease. Identifying the factors able to predict cognitive worsening since the early stage may improve disease management. The objective of this study was to define the best predictors of future cognitive worsening in a group of patients with newly diagnosed PD and to propose cutoff values potentially useful at the individual level.Fifty-four consecutive drug-naive patients with de novo PD were prospectively evaluated by clinical and neuropsychological assessment, resting EEG, andStep-wise logistic regression selected the posterior qEEG mean frequency andResting EEG and

Published
2017

5. Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder

Author

Karel Sonka, Thomas R Barber, Michele Terzaghi, Michal Rolinski, Fabio Pizza, Petr Dusek, Masayuki Miyamoto, Riccardo Meli, Matteo Bauckneht, Giuseppe Plazzi, Flavio Nobili, Bradley F. Boeve, Alessandra Serra, Lennon Jordan, Jiří Trnka, Raffaele Manni, Andrea Chincarini, Naoko Tachibana, Daniel R. McGowan, Val J. Lowe, Tomoyuki Miyamoto, Silvia Morbelli, Monica Puligheddu, Michela Figorilli, Elena Antelmi, David Zogala, Irene Bossert, Valérie Cochen De Cock, Toji Miyagawa, Dario Arnaldi, Delphine de Verbizier, Kevin M. Bradley, Michele T.M. Hu, Arnaldi, Dario, Chincarini, Andrea, Hu, Michele T, Sonka, Karel, Boeve, Bradley, Miyamoto, Tomoyuki, Puligheddu, Monica, De Cock, Valérie Cochen, Terzaghi, Michele, Plazzi, Giuseppe, Tachibana, Naoko, Morbelli, Silvia, Rolinski, Michal, Dusek, Petr, Lowe, Val, Miyamoto, Masayuki, Figorilli, Michela, de Verbizier, Delphine, Bossert, Irene, Antelmi, Elena, Meli, Riccardo, Barber, Thomas R, Trnka, Jiří, Miyagawa, Toji, Serra, Alessandra, Pizza, Fabio, Bauckneht, Matteo, Bradley, Kevin M, Zogala, David, McGowan, Daniel R, Jordan, Lennon, Manni, Raffaele, and Nobili, Flavio

Subjects
Male, medicine.medical_specialty, Synucleinopathies, Unified Parkinson's disease rating scale, Kaplan-Meier Estimate, REM Sleep Behavior Disorder, Logistic regression, REM sleep behavior disorder, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Aged, Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Dopamine Plasma Membrane Transport Proteins, Mini–Mental State Examination, medicine.diagnostic_test, Proportional hazards model, business.industry, Parkinsonism, Hazard ratio, Putamen, Original Articles, Middle Aged, medicine.disease, Confidence interval, REM sleep behaviour disorder, ROC Curve, SPECT, Parkinson’s disease, Female, Neurology (clinical), dementia with Lewy bodies, Caudate Nucleus, business, 030217 neurology & neurosurgery, Tropanes
Abstract

This is an international multicentre study aimed at evaluating the combined value of dopaminergic neuroimaging and clinical features in predicting future phenoconversion of idiopathic REM sleep behaviour (iRBD) subjects to overt synucleinopathy. Nine centres sent 123I-FP-CIT-SPECT data of 344 iRBD patients and 256 controls for centralized analysis. 123I-FP-CIT-SPECT images were semiquantified using DaTQUANTTM, obtaining putamen and caudate specific to non-displaceable binding ratios (SBRs). The following clinical variables were also analysed: (i) Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale, motor section score; (ii) Mini-Mental State Examination score; (iii) constipation; and (iv) hyposmia. Kaplan-Meier survival analysis was performed to estimate conversion risk. Hazard ratios for each variable were calculated with Cox regression. A generalized logistic regression model was applied to identify the best combination of risk factors. Bayesian classifier was used to identify the baseline features predicting phenoconversion to parkinsonism or dementia. After quality check of the data, 263 iRBD patients (67.6 ± 7.3 years, 229 males) and 243 control subjects (67.2 ± 10.1 years, 110 males) were analysed. Fifty-two (20%) patients developed a synucleinopathy after average follow-up of 2 years. The best combination of risk factors was putamen dopaminergic dysfunction of the most affected hemisphere on imaging, defined as the lower value between either putamina (P

Published
2020
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6. Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases

Author

Susanna Lopez, Lutfu Hanoglu, Raffaele Ferri, Raffaella Franciotti, Lucia Fraioli, Heinrich Garn, Francesco Famà, Dag Aarsland, Fabrizia D'Antonio, Bahar Güntekin, Andrea Soricelli, Peter Fuhr, Maria Francesca De Pandis, Görsev Yener, Marco Onofrj, Maria Teresa Pascarelli, Laura Bonanni, Carla Buttinelli, Francesco Orzi, Valentina Catania, Claudio Babiloni, Franco Giubilei, Erol Başar, Giuseppe Noce, Gerhard Ransmayr, John-Paul Taylor, Michela Pievani, Giovanni B. Frisoni, Claudio Del Percio, Antonio Ivano Triggiani, Carlo de Lena, Flavio Nobili, Laura Vacca, Derya Durusu Emek-Savaş, Ute Gschwandtner, Roberta Lizio, Dario Arnaldi, Paola Stirpe, Fabrizio Stocchi, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stocchi, Fabrizio, Vacca, Laura, Stirpe, Paola IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele, Pascarelli, Maria Teresa, Catania, Valentina IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neuroscience DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS AOU S Martino IST, Genoa, Italy, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Onofrj, Marco, Franciotti, Raffaella, Bonanni, Laura Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G dAnnunzio, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spital Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Med Fac, Kepler Univ Hosp, Dept Neurol 2, Med Campus 3, Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia Hosp San Raffaele Cassino, Cassino, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS Ist Ctr San Giovanni Dio Fatebenefratell, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, Frisoni, Giovanni B. Univ Hosp Geneva, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp Geneva, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Basar, Erol, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurol, Izmir, Turkey, Yener, Gorsev Dokuz Eylul Univ, IBG, Dept Neurosci, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, England, Guntekin, Bahar -- 0000-0002-0860-0524, Ferri, Raffaele -- 0000-0001-6937-3065, Pievani, Michela -- 0000-0002-1794-8987, triggiani, antonio ivano -- 0000-0003-3291-9452, Taylor, John-Paul -- 0000-0001-7958-6558, and Aarsland, Dag -- 0000-0001-6314-216X

Subjects
0301 basic medicine, Male, Audiology, 0302 clinical medicine, mild cognitive impairment due to dementia with Lewy bodies, media_common, resting state electroencephalographic rhythms, medicine.diagnostic_test, Exact low resolution brain electromagnetic source tomography (eLORETA), General Neuroscience, Brain, Electroencephalography, Signal Processing, Computer-Assisted, General Medicine, Psychiatry and Mental health, Clinical Psychology, mild cognitive impairment due to Alzheimer’s disease, receiver operating characteristic curve, Educational Status, Female, Alzheimer's disease, Vigilance (psychology), Lewy Body Disease, medicine.medical_specialty, media_common.quotation_subject, Rest, 03 medical and health sciences, Exact low resolution brain electromagnetic source tomography (eLORETA), mild cognitive impairment due to Alzheimer's disease, mild cognitive impairment due to dementia with Lewy bodies, receiver operating characteristic curve, resting state electroencephalographic rhythms, Alzheimer Disease, medicine, Humans, Cognitive Dysfunction, Aged, Retrospective Studies, Psychotropic Drugs, Mini–Mental State Examination, Resting state fMRI, Lewy body, Dementia with Lewy bodies, business.industry, medicine.disease, Mild Cognitive Impairment Due to Alzheimer's Disease, 030104 developmental biology, Delta Rhythm, ddc:618.97, Geriatrics and Gerontology, Occipital lobe, business, 030217 neurology & neurosurgery
Abstract

WOS: 000424245200019 PubMed ID: 29439335 The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC > 0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. H2020 Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Bodies. The members and institutional affiliations of the Consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bbdiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018

7. Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

Author

Franco Giubilei, Ute Gschwandtner, Raffaella Franciotti, Roberta Lizio, Gerhard Ransmayr, Fabrizio Stocchi, Dag Aarsland, John-Paul Taylor, Giuseppe Noce, Bahar Güntekin, Laura Vacca, Claudio Babiloni, Raffaele Ferri, Peter Fuhr, Antonio Ivano Triggiani, Dario Arnaldi, Lucia Fraioli, Claudio Del Percio, Paola Stirpe, Susanna Lopez, Lutfu Hanoglu, Francesco Orzi, Marco Onofrj, Laura Bonanni, Maria Francesca De Pandis, Carlo de Lena, Flavio Nobili, Andrea Soricelli, Michela Pievani, Giovanni B. Frisoni, Derya Durusu Emek-Savaş, Carla Buttinelli, Francesco Famà, Erol Başar, Heinrich Garn, Görsev Yener, Fabrizia D'Antonio, Babiloni, Claudio, Lizio, Roberta, Lopez, Susanna Univ Roma La Sapienza, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy, Stocchi, Fabrizio, Stirpe, Paola, Vacca, Laura IRCCS San Raffaele Pisana, Inst Res & Med Care, Rome, Italy, Del Percio, Claudio, Noce, Giuseppe, Soricelli, Andrea IRCCS, SDN, Dept Integrated Imaging, Naples, Italy, Soricelli, Andrea Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy, Ferri, Raffaele IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy, Nobili, Flavio, Arnaldi, Dario, Fama, Francesco Univ Genoa, Dept Neurosci DiNOGMI, Clin Neurol, Genoa, Italy, Fama, Francesco IRCCS, AOU S Martino IST, Genoa, Italy, Aarsland, Dag Kings Coll Univ, Dept Old Age Psychiat, London, England, Orzi, Francesco, Buttinelli, Carla, Giubilei, Franco Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy, Onofrj, Marco, Franciotti, Raffaella, Bonanni, Laura Univ G Annunzio Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Chieti, Italy, Bonanni, Laura Univ G Annunzio Chieti Pescara, CESI, Chieti, Italy, Fuhr, Peter, Gschwandtner, Ute Univ Spita Basel, Abt Neurophysiol, Basel, Switzerland, Ransmayr, Gerhard Johannes Kepler Univ Linz, Gen Hosp City Linz, Dept Neurol & Psychiat, Linz, Austria, Ransmayr, Gerhard Johannes Kepler Univ Linz, Gen Hosp City Linz, Fac Med, Linz, Austria, Garn, Heinrich AIT Austrian Inst Technol GmbH, Vienna, Austria, Fraioli, Lucia, De Pandis, Maria Francesca Hosp San Raffaele Cassino, Cassino, Italy, Pievani, Michela, Frisoni, Giovanni B. IRCCS, Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy, Frisoni, Giovanni B. Univ Hosp, Lab Neuroimaging Aging, Memory Clin, Geneva, Switzerland, Frisoni, Giovanni B. Univ Hosp, Lab Neuroimaging Aging, LANVIE, Geneva, Switzerland, Frisoni, Giovanni B. Univ Geneva, Geneva, Switzerland, D'Antonio, Fabrizia, De Lena, Carlo Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy, Guntekin, Bahar Istanbul Medipol Univ, Dept Biophys, Istanbul, Turkey, Hanoglu, Lutfu Univ Istanbul Medipol, Dept Neurol, Istanbul, Turkey, Bazar, Erol, Yener, Gorsev Dokuz Eyliil Univ, IBG, Dept Neurol, Izmir, Turkey, Yener, Gorsev Dokuz Eyliil Univ, IBG, Dept Neurosci, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eyliil Univ, Dept Psychol, Izmir, Turkey, Emek-Savas, Derya Durusu Dokuz Eyliil Univ, Dept Neurosci, Izmir, Turkey, Triggiani, Antonio Ivano Univ Foggia, Dept Clin & Expt Med, Foggia, Italy, Taylor, John Paul Newcastle Univ, Inst Neurosci, Newcastle, NSW, Australia, Vacca, Laura Casa Cura Privata Policlin CCPP Milano SpA, Milan, Italy, Guntekin, Bahar -- 0000-0002-0860-0524, Pievani, Michela -- 0000-0002-1794-8987, triggiani, antonio ivano -- 0000-0003-3291-9452, Ferri, Raffaele -- 0000-0001-6937-3065, Stocchi, Fabrizio -- 0000-0002-5763-0033, Babiloni, Claudio -- 0000-0002-5245-9839, Emek-Savas, Derya Durusu -- 0000-0001-7042-697X, Taylor, John-Paul -- 0000-0001-7958-6558, nobili, flavio -- 0000-0001-9811-0897, and Aarsland, Dag -- 0000-0001-6314-216X

Subjects
0301 basic medicine, Male, Aging, Parkinson's disease, Resting-state EEG rhythms, Dementia with Lewy bodies, Audiology, Electroencephalography, neuroscience, 0302 clinical medicine, Cognition, Resting State EEG Rhythms, Cortical Synchronization, Cognition/physiology, Cerebral Cortex, medicine.diagnostic_test, General Neuroscience, Neurodegenerative diseases, Alzheimer's disease, 16. Peace & justice, Dementia/diagnosis/etiology/physiopathology/psychology, Cortical Synchronization/physiology, Female, Alzheimer’s disease, Lewy Body Disease, medicine.medical_specialty, animal structures, Alzheimer Disease/complications, Rest, Alpha (ethology), behavioral disciplines and activities, 03 medical and health sciences, Lewy Body Disease/complications, Alzheimer Disease, mental disorders, medicine, Dementia, Humans, Dementia with Lewy Bodies, Functional brain connectivity, Neuroscience (all), Neurology (clinical), Developmental Biology, Geriatrics and Gerontology, Resting state EEG rhythms, dementia, dementia with Lewy bodies, functional brain connectivity, neurodegenerative diseases, resting-state EEG rhythms, aging, neurology (clinical), developmental biology, geriatrics and gerontology, Aged, Mini–Mental State Examination, Lewy body, Resting state fMRI, Rest/physiology, medicine.disease, nervous system diseases, 030104 developmental biology, ddc:618.97, Parkinson’s disease, Cerebral Cortex/diagnostic imaging/physiology, 030217 neurology & neurosurgery
Abstract

WOS: 000428233700003 PubMed ID: 29407464 Previous evidence showed abnormal posterior sources of resting-state delta (< 4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Hold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels. (C) 2017 Elsevier Inc. All rights reserved. H2020 Marie S. Curie ITN-ETN project The present study was developed based on the data of the informal European Consortium PDWAVES and European Consortium of Dementia with Lewy Body. The members and institutional affiliations of the consortia are reported in the cover page of this manuscript. The research activities of the Unit of University of Rome "La Sapienza" were partially supported by the H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" (http://bddiag-itn-etn.eu). We thank Mrs. Jessica Janson and Mrs. Marina Selivanova for their support to those activities in the framework of the BBDiag project.

Published
2018
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