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Understanding factors that regulate the patterns of diversity, richness, and density of organisms is of enormous importance to manage biodiversity in a global change context. We investigate the importance of environmental factors in regulating the patterns of diversity, richness, and density of diurnal butterflies in the Sierra Nevada mountain range (SE Spain). Diversity, richness, and density seem to be strongly correlated, being mainly defined by land-use and topographic-related variables. The sites with the highest values correspond to areas of dense scrubland, near patches of forest, oriented to the west and with a high rate of solar radiation but not excessively exposed from the topographical point of view. Topographic wetness index seems to be also important but with a positive relation in the case of density and negative in the case of diversity and richness. Our results show a pattern of mid-elevation maxima, with highest values between 1600 and 2000 masl and lower in the summits and the piedmont (

Background Aortic stenosis is one of the most prevalent valve diseases but is rarely accompanied by tricuspid regurgitation. Our objective was to analyse the impact of tricuspid regurgitation severity and its surgical treatment on prognosis of patients undergoing aortic valve replacement. Methods Retrospective cohort study including all patients presenting with aortic stenosis with some degree of tricuspid regurgitation between 2001 and 2018. Patients were divided into groups according to the degree of tricuspid regurgitation. Results From a sample of 8,080 patients with aortic stenosis, 143 (1,8%) presented with more than trace tricuspid regurgitation. Among patients with mild, moderate, or severe tricuspid regurgitation, we observed no differences in 30-day (15,1 vs 14,8 vs 8,7%;p=0,727), 12-month (51,2 vs 56 vs 55%;p=0,892) or 5-year (64 vs 73,3 vs 66,7%;p=0,798) survival. Aortic valve replacement plus tricuspid annuloplasty, when compared with aortic valve replacement only was associated with longer ICU stay (9 vs 3 days;p=0,043) but not higher 30-day (0 vs 15,5%;p=0,112), 12-month (38,5 vs 54,3%;p=0,278) or 5-year mortality (57,1 vs 67.1%;p=0,594). Only history of liver disease and postoperative major morbidity were independent predictors of survival 30 days, 12 months and 5 years after surgery. Conclusions Severity of tricuspid regurgitation in patients with aortic stenosis was not associated with increased mortality. Tricuspid annuloplasty did not improve survival in this subset of patients but was associated with increased postoperative morbidity.

Clouds on Mars are primary elements for understanding the past and present climate of the planet. Cloud particles can affect the energy balance of the planet, and so the atmospheric dynamic, as well as influence the vertical distribution of dust particles through dust scavenging. The dust scavenging by clouds has critical consequences in the water cycle of the planet; e.g. regions in the atmosphere with insufficient quantity of dust particles (or condensation nuclei) can inhibit the formation of H2O clouds and thus lead to the presence of water vapor in excess of saturation. The study of these interactions requires observations whose analysis allows us to infer simultaneously the properties of both the clouds and dust. To address these observations, the Radiation and Dust Sensor (RDS) is part of the Mars Environmental Dynamics Analyzer (MEDA) payload onboard of the Mars 2020 rover Perseverance.In this work we analysed the RDS observations made during twilight in the period Ls 39◦-262◦ to characterize the clouds above ∼ 30 km over the Perseverance rover site. From the ratio between the irradiance measured at zenith at 450 nm and 750 nm, we inferred that from Ls= 39◦ to 150◦ (referred as the cloudy period), water ice is the main constituent of the detected high-altitude aerosol layers. For Ls 150◦-262◦ dust is the main aerosol present. A total of 161 twilights were analysed in the cloudy period with a radiative transfer code in spherical geometry. Among other results we found: i) signatures of clouds or hazes on the RDS signals in the 58 % of the twilights; ii) most of the clouds were at altitudes between 40 km and 50 km and with particle sizes between 0.6 μm and 2 μm (in effective radius); iii) the cloud activity at sunrise is slightly higher that at sunset (65 % against 52 %), likely due to the differences in temperature; iv) the cloudiest time in Perseverance site and with the greatest cloud opacities is in Ls 120◦-150◦; and v) a notable decrease in the cloud activity around the aphelion (Ls ∼ 70◦), along with lower cloud altitudes and opacities. The drop in cloud activity around Ls ∼ 70◦ indicates lower concentrations of water vapor or cloud nuclei (dust) around this period in the Martian mesosphere. In this presentation, we will discuss the implications of our results on the water cycle of the planet.

Pressure measurements by the MEDA sensor on board Perseverance Rover show oscillations in a wide range of temporal scales, from the seasonal evolution of average pressure to rapid fluctuations on the scale of a few seconds. In this work, we profit from an entire Martian Year of pressure measurements to analyse the seasonal and daily evolution of rapid fluctuations, a signature of atmospheric turbulence. We find that during the full Martian year, fluctuations are enhanced at convective hours of the day, but the intensity of fluctuations is modulated through the seasons. At nighttime, the first half of the Martian years is characterized by an almost complete absence of fluctuations with an especially calm period in the early morning, while bursts of fluctuation become common in the dusty season. We also analyse the change of the daily pattern induced by regional dust storms at Jezero. We study the power spectra of the fluctuations to try to infer information about different turbulent regimes at the surface layer and their dependence on local time and season. Finally, we explore possible correlations with the dust load of the atmosphere and the temperature gradients, and we look at the origin of nighttime bursts of turbulence.

The Thermal Infrared Sensor (TIRS; Sebastián et al., 2021; Martínez et al., 2023) is one of the six sensor packages of the Mars Environmental Dynamics Analyzer (MEDA; Rodríguez-Manfredi et al., 2021), which in turn is one of the seven science instruments on board Perseverance. Here we show a summary of TIRS scientific highlights during the first Martian year of operations. In particular, TIRS is providing the first in situ determination of the surface radiative budget, direct determination of broadband albedo and thermal inertia (Martínez et al., 2023; Savijärvi et al., 2022), and around-the-clock determination of aerosol opacities (Smith et al., 2023). In addition, TIRS is providing ground-truth to orbital retrievals of thermal inertia and albedo, as well as geophysical characterization of the uppermost surface of the regolith during Phobos and Deimos eclipses. In synergy with other instruments, TIRS is being used to determine vertical profiles of temperature (Munguira et al., 2023), to detect dust lifting from sudden changes in albedo (Vicente-Retortillo et al., 2023), and to assess changes in the water content of the Martian soil (Hausrath et al., 2023), including the potential formation of frost. TIRS observations are critical to achieve MEDA’s first programmatic objective (validate global atmospheric models by measuring the radiative surface budget in preparation for future human exploration). Also, TIRS observations are important in support of flights of Ingenuity and therefore for the design and operations of future drones. References: Hausrath, E. M. et al. (2023), The SuperCam team and the Regolith working group, An Examination of Soil Crusts on the Floor of Jezero crater, Mars, Journal of Geophysical Research: Planets (accepted). Martínez, G. M. et al. (2023), Surface Energy Budget, Albedo and Thermal Inertia at Jezero Crater, Mars, as Observed from the Mars 2020 MEDA Instrument, Journal of Geophysical Research: Planets (accepted). Munguira, A. et al. (2023), Near Surface Atmospheric Temperatures at Jezero from Mars 2020 MEDA measurements, Journal of Geophysical Research: Planets (under review). Rodriguez-Manfredi, J.A. et al. (2021), The Mars Environmental Dynamics Analyzer, MEDA. A suite of environmental sensors for the Mars 2020 mission, Spa. Sci. Rev., 217(3), 1-86. Savijärvi, H. I. et al. (2022), Surface energy fluxes and temperatures at Jezero crater, Mars, Journal of Geophysical Research: Planets: e2022JE007438. Sebastián, E. et al. (2021), Thermal calibration of the MEDA-TIRS radiometer onboard NASA's Perseverance rover, Acta Astronautica, 182,144-159. Smith, M. D. et al. (2023), Diurnal and Seasonal Variations of Aerosol Optical Depth Observed by MEDA/TIRS at Jezero Crater, Mars, Journal of Geophysical Research: Planets (accepted). Vicente-Retortillo, A. et al. (2023), Dust Lifting Through Changes in Albedo at Jezero Crater, Mars, Journal of Geophysical Research: Planets (under review).

We use data from the MEDA instrument on Mars 2020 to study the evolution of atmospheric and surface temperatures at Jezero. The measurements correspond to four height levels from the surface to ~40 m and together they allow us to examine multiple aspects of the near-surface meteorology at Jezero. We extend the analysis of near-surface temperatures of Munguira et al. (JGR:Planets 2023), which covered the period from Ls 13º to Ls 203º, over a full Martian year. We show the seasonal evolution of temperatures, including temperature fluctuations and thermal gradients, which are affected by the properties of the terrain traversed by Perseverance. We will focus on a physical description of the thermal processes that take place in the Convective Boundary Layer at Jezero. We compare near-surface temperatures with the atmospheric opacity around-the-clock retrieved by Smith et al. (2022) and with daily averages of optical depth measured by MastCam-Z (Bell et al. 2022). After Ls 203º, atmospheric waves coming across Jezero predicted by atmospheric models are expected to contribute to shaping temperatures producing thermal oscillations on time-scales of a few sols. This effect is accompanied by an enhanced variability of atmospheric opacity and both effects contribute to produce a higher variability on temperatures. References:[1] Munguira, A. et al. (2023). Near Surface Atmospheric Temperatures at Jezero from Mars 2020 MEDA Measurements. JGR: Planets.[2] Smith, M.D. et al. (2022). Diurnal and Seasonal Variations of Aerosol Optical Depth Observed by MEDA/TIRS at Jezero Crater, Mars. In Seventh international workshop on the Mars atmosphere: Modelling and observations (pp. 14-17).[3] Bell, J.F. et al. (2022). Geological, multispectral, and meteorological imaging results from the mars 2020 perseverance rover in jezero crater. Science Advances, 8 (47), eabo4856. doi: 10.1126/sciadv.abo485

After one year of surface operations at Jezero, the MEDA meteorological sensors have captured the signals produced by the close approach of hundreds of vortices and dust devils over different seasons and terrains. Here we update findings on the vortex and Dust Devils published in Hueso et al. (JGR: Planets, 2023). That work analyzed MEDA data from spring to early autumn identifying vortices as pressure drops and later characterizing them from the ensemble of MEDA measurements. In this updated analysis we show that, in winter, declining surface temperatures and smaller vertical gradients result in a wane of vortex activity. This decreased activity affects more the frequency of intense vortices (Δp >1.5 Pa) without showing a stiff decay in the total number of vortices (Δp>0.5 Pa). In this contribution we concentrate on the specific aspects of the thermodynamics of the vortices from temperature measurements obtained by MEDA that characterize the vertical thermal gradient at the time of the vortex passage. In addition, when vortices approach the rover closely in a favorable geometry (coming from the front of the vortex) we measure the increased temperatures inside the vortex. We also explore the increased nighttime vortex activity found on some sols, when pressure drops equivalent to those created by daytime vortices appear in the early morning before sunrise, with clusters of nighttime activity in winter and early spring.

We identify temporal variations in surface albedo at Jezero crater using first-of-their-kind high-cadence in-situ measurements of reflected shortwave radiation during the first 350 sols of the Mars 2020 mission. Simultaneous Mars Environmental Dynamics Analyzer (MEDA) measurements of pressure, radiative fluxes, winds, and sky brightness indicate that these albedo changes are caused by dust devils under typical conditions and by a dust storm at Ls ∼ 155°. The 17% decrease in albedo caused by the dust storm is one order of magnitude larger than the most apparent changes caused during quiescent periods by dust devils. Spectral reflectance measurements from Mastcam-Z images before and after the storm indicate that the decrease in albedo is mainly caused by dust removal. The occurrence of albedo changes is affected by the intensity and proximity of the convective vortex, and the availability and mobility of small particles at the surface. The probability of observing an albedo change increases with the magnitude of the pressure drop (ΔP): changes were detected in 3.5%, 43%, and 100% of the dust devils with ΔP < 2.5 Pa, ΔP > 2.5 Pa and ΔP > 4.5 Pa, respectively. Albedo changes were associated with peak wind speeds above 15 m·s−1. We discuss dust removal estimates, the observed surface temperature changes coincident with albedo changes, and implications for solar-powered missions. These results show synergies between multiple instruments (MEDA, Mastcam-Z, Navcam, and the Supercam microphone) that improve our understanding of aeolian processes on Mars. This research has been funded by the Comunidad de Madrid Project S2018/NMT-4291 (TEC2SPACE-CM), by the Spanish State Research Agency (AEI) Project MDM-2017-0737 Unidad de Excelencia “María de Maeztu”- Centro de Astrobiología (CSIC/INTA), by the Spanish Ministry of Science and Innovation (MCIN)/State Agency of Research (10.13039/501100011033) project RTI2018-098728-B-C31, and by the project PID2021-126719OB-C41, funded by MCIN/AEI/10.13039/501100011033/FEDER, UE. RH, ASL and AM were supported by Grant PID2019-109467GB-I00 funded by MCIN/AEI/10.13039/501100011033/. Part of the research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). We want to thank J. Bell for processing Mastcam-Z projections showing the entire TIRS FOV and to S. Navarro and the entire team for generating the processed wind sensor data.

The Mars Environmental Dynamics Analyzer (MEDA) instrument, on board the NASA’s Mars 2020 Perseverance rover, includes a number of sensors to characterize the Martian atmosphere. One of this sensors is the Radiation and Dust Sensor (RDS) that measures the solar irradiance at different wavelengths and geometries. We analyzed the RDS observations made during twilight for the period between sol 71 and 492 of the mission (Ls 39◦-262◦) to characterize the clouds over the Perseverance rover site. Using the ratio between the irradiance at zenith at 450 and 750 nm, we inferred that the main constituent of the detected high-altitude aerosol layers was ice from Ls= 39◦ to 150◦ (cloudy period), an dust from Ls 150◦-262◦. A total of 161 twilights were analyzed in the cloudy period using a radiative transfer code and we found: i) signatures of clouds/hazes in the signals in the 58 % of the twilights; ii) most of the clouds had altitudes between 40-50 km, suggesting water ice composition, and had particle sizes between 0.6 and 2 μm; iii) the cloud activity at sunrise is slightly higher that at sunset, likely due to the differences in temperature; iv) the time period with more cloud detections and with the greatest cloud opacities is during Ls 120◦-150◦; and v) a notable decrease in the cloud activity around the aphelion, along with lower cloud altitudes and opacities. This decrease in cloud activity indicates lower concentrations of water vapor or cloud condensation nuclei (dust) around this period in the Martian mesosphere.

The Mars Environmental Dynamics Analyzer instrument on Mars 2020 has five Atmospheric Temperature Sensors at two altitudes (0.84 and 1.45 m) plus a Thermal InfraRed Sensor that measures temperatures on the surface and at ∼40 m. We analyze the measurements from these sensors to describe the evolution of temperatures in Jezero up to mission sol 400 (solar longitude LS = 13°–203°). The diurnal thermal cycle is characterized by a daytime convective period and a nocturnal stable atmosphere with a variable thermal inversion. We find a linear relationship between the daytime temperature fluctuations and the vertical thermal gradient with temperature fluctuations that peak at noon with typical values of 2.5 K at 1.45 m. In the late afternoon (∼17:00 Local True Solar Time), the atmosphere becomes vertically isothermal with vanishing fluctuations. We observe very small seasonal changes in air temperatures during the period analyzed. This is related to small changes in solar irradiation and dust opacity. However, we find significant changes in surface temperatures that are related to the variety of thermal inertias of the terrains explored along the traverse of Perseverance. These changes strongly influence the vertical thermal gradient, breaking the nighttime thermal inversion over terrains of high thermal inertia. We explore possible detections of atmospheric tides on near-surface temperatures and we examine variations in temperatures over timescales of a few sols that could be indicative of atmospheric waves affecting near-surface temperatures. We also discuss temperatures during a regional dust storm at LS = 153°–156° that simultaneously warmed the near surface atmosphere while cooling the surface. We are very grateful to the entire Mars 2020 science operations team. We would like to thank two anonymous reviewers for comments and suggestions that helped us to improve the quality of the manuscript. A. Munguira is supported by the grant PRE2020-092562 funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future.” R. Hueso and A. Sánchez-Lavega are supported by Grant PID2019-109467GB-I00 funded by MCIN/AEI/10.13039/501100011033/and by Grupos Gobierno Vasco IT1742-22. US coauthors have been funded by NASA's STMD, HEOMD, and SMD. Part of the research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). B. Chide is supported by the Director's Postdoctoral Fellowship from the Los Alamos National Laboratory. M. Lemmon is supported by contract 15-712 from Arizona State University and 1607215 from Caltech-JPL. R. Lorenz was supported by JPL contract 1655893. G. Martínez acknowledges JPL funding from USRA Contract Number 1638782. A. Vicente-Retortillo is supported by the Spanish State Research Agency (AEI) Project No. MDM-2017-0737 Unidad de Excelencia “María de Maeztu”- Centro de Astrobiología (INTA-CSIC), and by the Comunidad de Madrid Project S2018/NMT-4291 (TEC2SPACE-CM). Researchers based in France acknowledge support from CNES for their work on Perseverance.

Taxa restricted to mountains may be vulnerable to global warming, unless localscale topographic variation and conservation actions can protect them against expected changes to the climate. We tested how climate change will affect the 19 mountain-restricted Erebia species of the Iberian Peninsula, of which 7 are endemic. To examine the scope for local topographic variation to protect against warming, we applied species distribution models (HadGEM2 and MPI) at two spatial scales (10 10 and 1 1 km) for two representative concentration pathways (RCP4.5 and RCP8.5) in 2050 and 2070. We also superimposed current and future ranges on the protected area (PA) network to identify priority areas for adapting Erebia conservation to climate change. 4. In 10 10 km HadGEM2 models, climatically suitable areas for all species decreased in 2050 and 2070 (average 95.7%). Modelled decreases at 1 1 km were marginally less drastic (95.3%), and 14 out of 19 species were still expected to lose their entire climatically favourable range by 2070. The PA network is well located to conserve the species that are expected to retain some climatically suitable areas in 2070. However, we identify 25 separate 10 10 km squares where new PAs would help to adapt the network to expected range shifts or contractions by Erebia. Based on our results, adapting the conservation of range-restricted mountain taxa to projected climate change will require the implementation of complementary in situ and ex situ measures alongside urgent climate change mitigation., This study was supported by the project BIOUAM07-2019 founded by Biology Department from Universidad Autonoma de Madrid, the project IBERARTRO (SBPLY/17/180501/000492) funded by European Regional Development Fund (ERDF) through the Consejería de Educacion, Ciencia y Cultura, Junta de Comunidades de Castilla-La Mancha, the project RTI2018-096739-B-C21 funded by MCIU/AEI/ FEDER, UE, and the NexTdive project (PID2021-124187NB-I00) funded by the Spanish Ministry of Science and Innovation.

Introduction The most frequent cardiac primary tumors are Mixomas, typically being located in the left atrium. They are usually incidental findings, but probable symptoms include constitutional syndrome, syncope, congestive symptoms, or embolism. The diagnosis is based upon clinical imaging tests (with the TEE being the test of choice) which define the characteristics of the chosen treatment, surgery. Clinical case A 79-year-old female with a medical history of HTA and Diabetes with retinopathy nephropathy. She was hospitalized 2 months earlier with a constitutional syndrome being diagnosed of a Giant cell arteritis. Then she came to the emergency room presenting with oliguria, edema and dyspnea with a 10 kg weight loss. The tests performed showed low voltajes in the EKG, anemization and the TTE showed a mass inside the right atrium. Then she was hospitalized and a CT scan confirmed the presence of an aparent Mixoma. The patient was treated with surgery and the diagnosis was confirmed by pathology. Discussion We are describing the case of a pluripathological patient with congestive symptoms due to cardiac insuffciency, so the differential diagnosis must include thromboembolisms, valvulopathies and pulmonary hypertension. The constitutional syndrome can be explained due to the relation of the Mixoma with IL-6 and the anemization could be caused by the hemolyisis of the tumor. After two years of the surgery no further symptoms appeared, and no evidence of the mass where it had been seen in the imaging tests.

Introduction Atrial septal defects are the second most frequent congenital heart diseases and their treatment of choice is the percutaneous approach. Complications associated are infrequent and are mainly related with the puncture. Other complications such as embolism or endocarditis are uncommon. Clinical case A 17-year-old woman whose only medical history of interest was an ostium secundum-type atrial septal defect that was treated percutaneously implanting a 24-mm Amplatzer septal occlude. 15 months after the procedure she came to the emergency room presenting 40°C fever and a headache. Physical examination and tests results were normal, being discharged with antibiotic treatment. She returned 24 hours later due to persistence of the same symptoms. An echocardiogram was performed, revealing an endocarditic growth and uncomplete endothelization of the amplatzer. Following 10 days of antibiogram-guided therapy with good response, she underwent surgery. The device was extracted and the defect closed. PCR was positive for H. Parainfluenzae. The patient was discharged on the 7th day with antibiotic therapy. Discussion This case is relevant due to the late presentation of IE, incomplete endothelization and to being caused by infrequent IE germ source with a negative blood culture. Despite the low prevalence of these complications, it is necessary to rule them out through imaging tests as well as microbiological tests. Appropriate length of bacterial coverage usually extends from 6 months to 1 year after implantation. Documented cases of prosthetic IE related to incorrect endothelial coverage can lead to reassessing the time period during which prophylaxis should be maintained.

Supplementary Material 2

Supplementary Material 1

Background Anti‐SARS‐CoV‐2 S antibodies prevent viral replication. Critically ill COVID‐19 patients show viral material in plasma, associated with a dysregulated host response. If these antibodies influence survival and viral dissemination in ICU‐COVID patients is unknown. Patients/Methods We studied the impact of anti‐SARS‐CoV‐2 S antibodies levels on survival, viral RNA‐load in plasma, and N‐antigenaemia in 92 COVID‐19 patients over ICU admission. Results Frequency of N‐antigenaemia was >2.5‐fold higher in absence of antibodies. Antibodies correlated inversely with viral RNA‐load in plasma, representing a protective factor against mortality (Adjusted HR [CI 95%], p): (S IgM [AUC ≥ 60]: 0.44 [0.22; 0.88], 0.020); (S IgG [AUC ≥ 237]: 0.31 [0.16; 0.61]

Since February 18, 2021, Perseverance has been exploring Jezero Crater (18ºN, 77ºE). The meteorology of this location is being investigated with the Mars Environmental Dynamics Analyzer (MEDA) [1], which among many other sensors has 5 Air Temperature Sensors (ATS) to measure near surface temperatures. These sensors are located at two altitudes: two are at 0.85 m, in the front of the rover, and three are at 1.45 m around the Remote Sensing Mast (RSM), distributed azimuthally so that at least one sensor is located upwind. Local air temperatures are measured with a frequency that can be as high as 2 Hz. In addition, the temperature of the surface and at an approximate altitude of about 40 m are measured with the Thermal Infrared Sensor (TIRS), which operates with a sampling frequency of 1 Hz. MEDA records atmospheric variables typically over 50% of a full sol. Here we present consolidated analysis of data up to sol 400, which covers a period from the start of northern Spring (Ls=5º) to early Autumn (beyond Ls=180º). This analysis takes into account different instrumental effects affecting ATS and TIRS which have been characterized over the course of the mission. Firstly, we will present the daily temperature cycle at Jezero, including mean values and its fluctuations plus their daily and seasonal evolution. Hence, we report phenomena at various altitudes, in different time scales, ranging from thermal tides to continuous rapid fluctuations, as well as the effects caused by the different environments as Perseverance explores Jezero. The convective and calmed regimes, at daytime and nighttime respectively, and the transitions between them are well differentiated in the MEDA data and can be well characterized. We will also discuss vertical thermal gradients (surface to 40 m altitude) along the mission and the evolution of nighttime inversions. Secondly, we quantify the influence of different forcings on temperatures: The thermal changes associated with clouds, dust load, variations of the solar flux and changes in the surface properties on the ground and near-surface temperatures. Specific effects associated with a regional dust storm over Jezero will be presented. Lastly, we will comment on the comparison of temperatures at Jezero with in situ data from other locations [2-3] and models [4-5]. [1] Rodriguez-Manfredi, J. A., et al. (2021). The Mars Environmental Dynamics Analyzer, MEDA. A suite of environmental sensors for the Mars 2020 mission. Space science reviews, 217(3), 1-86. [2] Davy, R., et al. (2010). Initial analysis of air temperature and related data from the Phoenix MET station and their use in estimating turbulent heat fluxes. Journal of Geophysical Research: Planets, 115(E3). [3] Mason, E. L., & Smith, M. D. (2021). Temperature fluctuations and boundary layer turbulence as seen by Mars Exploration Rovers Miniature Thermal Emission Spectrometer. Icarus, 360, 114350. [4] Newman et al. (2020). Multi-model Meteorological and Aeolian Predictions for Mars2020 and the Jezero Crater Region, Space Sci. Rev. 215, 148. [5] Pla-García et al., (2020). Meteorological Predictions for Mars 2020 Perseverance Rover Landing Site at Jezero, Space Sci. Rev., 215, 148.

The aim of this investigation is to carry out a study of the variability of nocturnal atmospheric turbulence at Jezero crater supported by modeling effort and monitored by MEDA. The rapid turbulent kinetic energy (hereafter TKE), wind and pressure fluctuations observed during nighttime both with modeling and MEDA is a clear indicator of nocturnal turbulence. The origin of this nocturnal turbulence is explored with MRAMS and, as opposed to Gale crater, low evidence of significant gravity waves activity during the whole period studied was found. On the contrary, the nighttime turbulence at Jezero crater could be shear driven and may be explained due to an enhanced mechanical turbulence produced by increasingly strong shear (onset of a strong low-level jet) at the nocturnal inversion interface. As the nocturnal inversion develops, the winds above become decoupled from the surface and the decrease in friction produces a net acceleration [refs 4, 5, 6, 7]. Once the critical Richardson Number is reached (Ri ∼< 0.25, Figure 3), shear instabilities can mix warmer air aloft down to the surface [refs 8, 9, 10]. 1. Introduction The Mars 2020 Perseverance rover landed in Mars in February 2021 at 18.44°N 77.45°E within and near the northwest rim of Jezero crater. The MEDA weather station is aboard Perseverance rover [ref 1]. 2. MRAMS mesoscale simulations MRAMS was applied to Mars 2020 landing site region using nested grids with a spacing of 330 meters on the innermost grid that is centered over the landing site [ref 2]. 3. Nighttime turbulence modeled with MRAMS The effect of subgrid-scale eddies is captured within MRAMS via a prognostic TKE (Figure 1) equation [ref 3]. MRAMS shows a peak in TKE during the afternoon, which is consistent with the modeled high-frequency variations in air temperatures [Figure 3 of ref 2]. The sudden increase in air temperature during the evenings [Figure 3 of ref 2] at the onset of radiative cooling is produced by mechanically driven turbulence since the atmosphere is stable and non-convective in the evening. The model does often show small increases of TKE during the night (Figure 1), especially during Ls=180º (corresponding to Mars 2020 sol 362) and some during Ls 105 and Ls 160 (corresponding to Mars 2020 sols 216 and 326), that could be associated with the turbulent aspects of the nighttime dynamical flows when compared with nearby locations with more flat topography. During the late evening and night, MRAMS is resolving thermal variations [2, Figure 3] and does often show small increases of TKE at that time (Figure 1). The rapid air temperature fluctuations modeled at night in all seasons is indicative of nocturnal turbulence. There is low evidence of significant wave activity during the whole period studied and only some gravity waves were found. The nighttime turbulence could be attributed to shear driven turbulence and may be explained due to an enhanced mechanical turbulence driven by increasingly strong shear, with the onset of the nocturnal low-level jet, at the nocturnal inversion interface (an example on Figure 2). Based on GCM model efforts, looks like the low-level jet is a large scale circulation feature. The westward wind at 2 km altitude shown on Figure 2 is also show up nicely in the MCD. The jet could be forced by the diurnal cycle. The dustier atmosphere, when arrival of northern autumn equinox, also contributes to decrease the nighttime Richardson number by two means: strengthening of the nighttime low-level jet deeping the near-surface wind shear and weakening near-surface atmospheric stability by increasing the nighttime surface temperature and decreasing of atmospheric temperature. A third possible strengthening of the nighttime turbulence at Jezero could be the convergence, after 01:00 LTST, of downslope winds blowing from NW rim fighting against SE winds blowing both from east crater rims and from Jezero mons (located SE outside the crater), producing a big whirlpool inside the crater (Figure 4) that could be the responsible of the high variability of wind directions observed by MEDA. 4. Nightime turbulence observed with MEDA The rapid fluctuations of pressure (moreover during high dust periods), TKE (derived only with horizontal wind speeds, that will be updated with vertical winds in the future) and wind speeds observed during nighttime with MEDA (Figures 5 and 6) is a clear indication of nocturnal turbulence. 5. Figures Figure 1: TKE diurnal cycle predicted with MRAMS for Jezero crater at Ls0, 60, 90, 105, 160, 180 and 270. Figure 2: MRAMS vertical cross-section (Jezero’s west rim to east rim) at 21:35 LTST of Ls=180º -corresponding to Mars 2020 sol #362- of total wind (zonal + meridional) in colored shadowed, zonal + vertical (exaggerated x5) wind in white arrows and TKE in black contours. The west crater rim is the hill on the left. Perseverance rover is located at x ≈ 17 km. Figure 3: MRAMS vertical profiles of wind magnitude, wind shear, Richardson number (Ri) and TKE for Ls180 at Mars 2020 location corresponding to Mars 2020 sol #362 (Ls=180º). Once the critical Richardson Number is reached (Ri ∼< 0.25, red line). Figure 4: Near-surface winds (vectors) and potential temperature (shaded) as predicted on numerical grid 5. Vectors are plotted at every other grid point. Topography contours are shown in black. Wind vector scale is shown in the bottom right area of the panels. hh:mm LTST on the top right. A big whirlpool inside the crater could be responsible for the large variability of wind directions observed by MEDA after 01:00 LTST. Figure 5: MEDA TKE (derived only with horizontal wind speeds, that will be updated with vertical winds in the future), wind direction and horizontal wind speed instantaneous measurements for the period 00:14 to 00:23 LTST at sol #73. Figure 6: Diurnal cycle of MEDA TKE averaged over 5 min for sols #73-87. 6. References [1] Rodriguez-Manfredi et al. 2020; [2] Pla-Garcia et al. 2021; [3] Mellor and Yamada 1974; [4] Davis 2000; [5] Blackadar 1957; [6] Thorpe and Guymer 1977; [7] Mahrt 1981; [8] Miles 1961; [9] Banfield et al. 2020; [10] Chatain et al. 2021

The Mars 2020 Perseverance rover is developing its mission in Jezero crater [1], a north tropical location that is rich in vortices and dust devils [2]. The MEDA instrument [3] collects atmospheric data at a typical frequency of 1 Hz with several sensors including pressure and winds. It also registers data about atmospheric dust with its set of photodiodes [4]. Together, these data are providing a large set of detections of vortices and dust devils [2, 5] that can be used to investigate the physical properties of the vortices and their effects on the environment though the combination of additional data obtained by MEDA. Here we present a physical characterization of dust devils detected with the pressure data and confirmed as dust devils from the set of photodiodes on MEDA. We show that the combination of pressure, winds and a simple model of drifting vortices [6] can fit the observations of many of these events determining their true central pressure drop, diameter and maximum circulation winds. The quality of the comparisons depend on the varying quality of the wind measurements and is better in short encounters with small vortices than in long encounters with large dust devils. We examine how the vortices characteristics, i.e. their true diameter, minimum distance of the encounter, central pressure drop and maximum wind intensity compare with the detection of dust and its basic inferred abundance and explore the consequences for the efficiency of vortices of different sizes and intensities to raise dust from the Martian surface. We also compare these vortex parameters with environment thermal properties, such as the thermal gradient from the surface and the air, and the thermal perturbations caused by the vortex in a selection of the best observed cases. A comparison with main properties of vortices observed in the different surveys of dust devil activity carried on by the cameras onboard Perseverance will be also presented. References:[1] Farley, K.A. et al. Mars2020 Mission Overview, Space Sci. Rev., 216, 142 (2020). Doi: 10.1007/s11214-020-00762-y[2] Newman, C.E. et al. The dynamic atmospheric and aeolian environment of Jezero crater, Mars, Science Advances (in press).[3] Rodriguez-Manfredi, J.A. et al. The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission, Space Science Reviews, 217, 48 (2021), doi:10.1007/s11214-021-00816-9.[4] Apestigue, V. et al. Radiation and Dust Sensor for Mars Environmental Dynamic Analyzer Onboard M2020 Rover. Sensors, 22, 2907 (2022). doi:10.3390/s22082907[5] Jackson, B. Vortices and Dust Devils as Observed by the Mars Environmental Dynamics Analyzer Instruments on Board the Mars 2020 Perseverance Rover, The Planetary Science Journal, 3, 20 (2022). Doi: 103847/PSJ/ac4586[6] Lorenz, R., Heuristic estimation of dust devil vortex parameters and trajectories from single-station meteorological observations: Application to InSight at Mars. Icarus, 271, 326-337 (2016). doi: 10.1016/j.icarus.2016.02.001

Background More than 20% of hospitalized patients with COVID-19 demonstrate ARDS requiring ICU admission. The long-term respiratory sequelae in such patients remain unclear. Research Question What are the major long-term pulmonary sequelae in critical patients who survive COVID-19? Study Design and Methods Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-min walking test [6MWT]), and chest CT imaging. Results One hundred twenty-five patients admitted to the ICU with ARDS secondary to COVID-19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%) and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median distance in the 6MWT was 400 m (interquartile range, 362-440 m). CT scans showed abnormal results in 70.2% of patients, demonstrating reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT scan showed worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT scan were age and length of invasive mechanical ventilation during the ICU stay. Interpretation Three months after hospital discharge, pulmonary structural abnormalities and functional impairment are highly prevalent in patients with ARDS secondary to COVID-19 who required an ICU stay. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months after discharge.

Patients undergoing surgical aortic valve replacement (SAVR) are at high risk for atrial fibrillation (AF) and stroke after surgery. There is an unmet clinical need to improve stroke prevention in this patient population. The LAA-CLOSURE trial aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patients undergoing bioprosthetic SAVR. This randomized, open-label, prospective multicenter trial will enroll 1,040 patients at 13 European sites. The primary endpoint is a composite of cardiovascular mortality, stroke and systemic embolism at 5 years. Secondary endpoints include cardiovascular mortality, stroke, systemic embolism, bleed fulfilling academic research consortium (BARC) criteria, hospitalization for decompensated heart failure and health economic evaluation. Sample size is based on 30% risk reduction in time to event analysis of primary endpoint. Prespecified reports include 30-day safety analysis focusing on AF occurrence and short-term outcomes and interim analyses at 1 and 3 years for primary and secondary outcomes. Additionally, substudies will be performed on the completeness of the closure using transesophageal echocardiography/cardiac computed tomography and long-term ECG recording at one year after the operation.

Economic recession has dire consequences on overall health. None have explored the impact of economic crisis (EC) on infective endocarditis (IE) mortality. We conducted a retrospective, nationwide, temporal trend study analyzing mortality trends by age, sex, and adverse outcomes in patients diagnosed with IE in Spain from 1997 to 2014. Data were divided into two subperiods: pre-EC (January 1997-August 2008) and post-EC (September 2008-December 2014). A total of 25 952 patients presented with IE. The incidence increased from 301.4 to 365.1 per 10 000 000 habitants, and the mortality rate rose from 24.3% to 28.4%. Those aged >75 years experienced more adverse outcomes. Complications due to sepsis, shock, acute kidney injury requiring dialysis, and heart failure increased after the EC onset, and expenditures soared to €16 216. Expenditure per community was related to mortality ( P

Data Availability Statement All Mars 2020 MEDA data necessary to reproduce each figure shown in this manuscript are available via the Planetary Data System (PDS) Atmospheres node (Rodriguez-Manfredi & de la Torre Juarez, 2021). An exception to this are the LWd values in the 5–80 μm range (Figures 8, 9, and 10 top, Figure 11 top, and Figure 15), and the aerosol opacity values derived from TIRS (Figure 10, middle and Figure 11, top), which are publicly available via the USRA Houston Repository (Martinez et al., 2022). THEMIS retrievals of thermal inertia shown in Figure 7 and TES retrievals of albedo in Figure 14 can be queried and processed using the open-source JMARS (Christensen et al., 2009) and MARSTHERM (Putzig et al., 2013) software. The Mars Environmental Dynamics Analyzer (MEDA) on board Perseverance includes first-of-its-kind sensors measuring the incident and reflected solar flux, the downwelling atmospheric IR flux, and the upwelling IR flux emitted by the surface. We use these measurements for the first 350 sols of the Mars 2020 mission (Ls ∼ 6°–174° in Martian Year 36) to determine the surface radiative budget on Mars and to calculate the broadband albedo (0.3–3 μm) as a function of the illumination and viewing geometry. Together with MEDA measurements of ground temperature, we calculate the thermal inertia for homogeneous terrains without the need for numerical thermal models. We found that (a) the observed downwelling atmospheric IR flux is significantly lower than the model predictions. This is likely caused by the strong diurnal variation in aerosol opacity measured by MEDA, which is not accounted for by numerical models. (b) The albedo presents a marked non-Lambertian behavior, with lowest values near noon and highest values corresponding to low phase angles (i.e., Sun behind the observer). (c) Thermal inertia values ranged between 180 (sand dune) and 605 (bedrock-dominated material) SI units. (d) Averages of albedo and thermal inertia (spatial resolution of ∼3–4 m2) along Perseverance's traverse are in very good agreement with collocated retrievals of thermal inertia from Thermal Emission Imaging System (spatial resolution of 100 m per pixel) and of bolometric albedo in the 0.25–2.9 μm range from (spatial resolution of ∼300 km2). The results presented here are important to validate model predictions and provide ground-truth to orbital measurements. Germán Martínez wants to acknowledge JPL funding from USRA Contract Number 1638782. A. V. R. is supported by the Spanish State Research Agency (AEI) Project MDM-2017-0737, Unidad de Excelencia “María de Maeztu”—Centro de Astrobiología (INTA-CSIC), and by the Comunidad de Madrid Project S2018/NMT-4291 (TEC2SPACE-CM). J. J. acknowledges funding from Mastcam-Z ASU subcontract 15-707. R. H., A. S. L., and A. M. were supported by Grant PID2019-109467GB-I00 funded by MCIN/AEI/10.13039/501100011033/ and by Grupos Gobierno Vasco IT1742-22. F. G. acknowledges financial support from the Agencia Estatal de Investigación of the Ministerio de Ciencia e Innovación and the European Regional Development Fund “A way of making Europe” through project the Centre of Excellence “María de Maeztu” award to the Centro de Astrobiología (MDM-2017-0737), and from the Instituto Nacional de Técnica Aeroespacial through Project S.IGS22001. L. M. was supported by CNES and IRIS-OCAV. J. P., M. H., and A.-M. H. are thankful for the Finnish Academy Grant 310509. M.-P. Z. was supported by Grant PID2019-104205GB-C21 funded by MCIN/AEI/10.13039/501100011033. M. de la T. J. acknowledges partial funding from the National Aeronautics and Space Administration (80NM0018D0004). The JPL co-authors acknowledge funding from NASA's Space Technology Mission Directorate and the Science Mission Directorate. Peerreview

We characterize vortex and dust devils (DDs) at Jezero from pressure and winds obtained with the Mars Environmental Dynamics Analyzer (MEDA) instrument on Mars 2020 over 415 Martian days (sols) (Ls = 6°–213°). Vortices are abundant (4.9 per sol with pressure drops >0.5 Pa correcting from gaps in coverage) and they peak at noon. At least one in every five vortices carries dust, and 75% of all vortices with Δp > 2.0 Pa are dusty. Seasonal variability was small but DDs were abundant during a dust storm (Ls = 152°–156°). Vortices are more frequent and intense over terrains with lower thermal inertia favoring high daytime surface-to-air temperature gradients. We fit measurements of winds and pressure during DD encounters to models of vortices. We obtain vortex diameters that range from 5 to 135 m with a mean of 20 m, and from the frequency of close encounters we estimate a DD activity of 2.0–3.0 DDs km−2 sol−1. A comparison of MEDA observations with a Large Eddy Simulation of Jezero at Ls = 45° produces a similar result. Three 100-m size DDs passed within 30 m of the rover from what we estimate that the activity of DDs with diameters >100 m is 0.1 DDs km−2sol−1, implying that dust lifting is dominated by the largest vortices in Jezero. At least one vortex had a central pressure drop of 9.0 Pa and internal winds of 25 ms−1. The MEDA wind sensors were partially damaged during two DD encounters whose characteristics we elaborate in detail. The authors are very grateful to the entire Mars 2020 science operations team. The authors would also like to thank Lori Fenton and an anonymous reviewer for many suggestions that greatly improved the manuscript. This work was supported by Grant PID2019-109467GB-I00 funded by MCIN/AEI/10.13039/501100011033/ and by Grupos Gobierno Vasco IT1742-22 and by the Spanish National Research, Development and Innovation Program, through the Grants RTI2018-099825-B-C31, ESP2016-80320-C2-1-R, and ESP2014-54256-C4-3-R. Baptiste Chide is supported by the Director's Postdoctoral Fellowship from the Los Alamos National Laboratory. M. Lemmon is supported by contract 15-712 from Arizona State University and 1607215 from Caltech-JPL. R. Lorenz was supported by JPL contract 1655893. Germán Martínez acknowledges JPL funding from USRA Contract Number 1638782. A. Munguira was supported by Grant PRE2020-092562 funded by MCIN/AEI and by “ESF Investing in your future.” A. Vicente-Retortillo is supported by the Spanish State Research Agency (AEI) Project No. MDM-2017-0737 Unidad de Excelencia “María de Maeztu”-Centro de Astrobiología (INTA-CSIC), and by the Comunidad de Madrid Project S2018/NMT-4291 (TEC2SPACE-CM). Part of the research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). Finnish researchers acknowledge the Academy of Finland Grant 328 310529. Researchers based in France acknowledge support from the CNES for their work on Perseverance.

Rovers and landers on Mars have experienced local, regional, and planetary-scale dust storms. However, in situ documentation of active lifting within storms has remained elusive. Over 5–11 January 2022 (LS 153°–156°), a dust storm passed over the Perseverance rover site. Peak visible optical depth was ∼2, and visibility across the crater was briefly reduced. Pressure amplitudes and temperatures responded to the storm. Winds up to 20 m s−1 rotated around the site before the wind sensor was damaged. The rover imaged 21 dust-lifting events—gusts and dust devils—in one 25-min period, and at least three events mobilized sediment near the rover. Rover tracks and drill cuttings were extensively modified, and debris was moved onto the rover deck. Migration of small ripples was seen, but there was no large-scale change in undisturbed areas. This work presents an overview of observations and initial results from the study of the storm. The authors acknowledge and thank the Mars 2020 team. The research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004). ML is supported by contract 15–712 from Arizona State University and 1607215 from Caltech-JPL. Funding for some Spain-based co-authors was provided by the Spanish Ministry of Economy and Competitiveness, through the projects No. ESP2014-54256-C4--4R and AYA2015-65041-P; Ministry of Science, Innovation and Universities, projects No. ESP2016-79612-C3-3R, ESP2016-80320-C2-1-R, RTI2018-098728-B- C33 and RTI2018-099825-B-C31; Instituto Nacional de Técnica Aeroespacial; Ministry of Science and Innovation's Centre for the Development of Industrial Technology; Grupos Gobierno Vasco IT1366-19; and European Research Council Consolidator Grant No. 818602. ASL, RH and AMR were supported by grant PID2019-109467GB-I00 funded by MCIN/AEI/10.13039/501100011033/and by Grupos Gobierno Vasco IT1366-19. A. V.-R. is supported by the Spanish State Research Agency (AEI) Project No. MDM-2017-0737 Unidad de Excelencia “María de Maeztu”- Centro de Astrobiología (INTA-CSIC). Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of funding agencies or the Space Science Institute. Peerreview

Perseverance's Mars Environmental Dynamics Analyzer (MEDA) is collecting data at Jezero Crater, characterizing the physical processes in the lowest layer of the atmosphere as no previous instrument did before. Here we show that temperature measurements at four heights capture the response of the atmospheric surface layer to multiple phenomena. We observe the transition from a stable nighttime thermal inversion to a diurnal, highly turbulent convective regime, with large vertical thermal gradients, and where local surface properties (such as Thermal Inertia) play an essential role. Recording multiple daily optical depths yielded higher aerosol concentrations in the morning than in the afternoon. Measured wind patterns are mainly driven by local topography, with a small contribution from regional winds. Daily and seasonal variability of relative humidity shows a complex hydrologic cycle. These observations raise new puzzles in which changes in surface albedo and thermal inertia may play an influential role. On a larger scale, surface pressure shows typical signatures of gravity waves and baroclinic eddies in a part of the seasonal cycle characterized before as low wave activity. These observations, combined and simultaneous, show the rich Jezero’s meteorology, and unveil the diversity of processes driving change on today’s Martian surface.

Resumen: Introducción: La diabetes mellitus 1 es la segunda enfermedad crónica y el trastorno endocrino-metabólico más frecuente en la infancia. Se estima una prevalencia entre 1,1 y 1,4/1000 menores de 15 años. En Andalucía la prevalencia es mayor (1,7 por mil).El objetivo del estudio es analizar la calidad de vida y adherencia al tratamiento, centrándonos en la población pediátrica de Andalucía. Métodos: Estudio analítico observacional transversal multicéntrico. La muestra fue de 178 pacientes de seis hospitales con Endocrinología Pediátrica. A cada paciente se le entregaron dos cuestionarios; la encuesta de calidad de vida (PedsQL versión 3.0) y adherencia al tratamiento SCI-R. Además, se recogieron datos demográficos, clínicos, del control metabólico, y complicaciones. Resultados: Se obtuvieron niveles altos tanto en la adherencia como en la calidad de vida. La primera se relacionó de forma inversa con la edad y la HbA1c, aunque el coeficiente fue tan bajo que no permite sacar conclusiones significativas. La calidad de vida se asoció con el uso de sistema de monitorización continua de glucosa en tiempo real (MCG-TR) integrado con ISCI, así como con menos hipoglucemias graves y complicaciones renales.La HbA1c media fue 7,1%. El 12,9% de los pacientes usaban ISCI. El 83,2% empleaban exclusivamente la glucemia capilar, mientras que el 16,8% usaba algún dispositivo de monitorización de glucosa intersticial. Conclusiones: Se trata del primer estudio realizado en Andalucía que analiza la calidad de vida en pacientes pediátricos. Los resultados muestran niveles altos de adherencia y de calidad de vida, además de un buen control metabólico. Abstract: Introduction: Diabetes mellitus 1 is the second most frequent chronic disease, and the most frequent endocrine-metabolic disorder in childhood. The estimated prevalence is between 1.1 and 1.4 / 1000 children under 15 years years-old. In Andalusia the prevalence is higher (1.7 per thousand).The objective of the study is to evaluate health-related quality of life (HRQoL) and adherence to treatment, specifically in the paediatric population of Andalusia. Methods: A multicentre cross-sectional observational analytical study was conducted on a sample of 178 patients from six hospitals with a Paediatric Endocrinology Unit. Each patient received two questionnaires; quality of life (PedsQL version 3.0) and adherence to the self-care recommendations (SCI-R) treatment. The demographic, clinical, metabolic control data, and possible complications were also collected. Results: High levels were obtained in both adherence and health-related quality of life (HRQoL). Adherence was inversely related to age and HbA1c. The health-related quality of life (HRQoL) was associated with the use of a continuous real-time glucose monitoring system (MCG-TR) combined with continuous subcutaneous insulin infusion (CSII), as well as with a lower number of severe hypoglycaemia and renal complications. The mean HbA1c was 7.1%. 12,9% of patients used ISCI. 83.2% used capillary glycemia exclusively, while 16.8% used some interstitial glucose monitoring device. Conclusions: This is the first study in Andalusia that analyzes the health-related quality of life (HRQoL) of pediatric patients. The results show high levels of adherence and health-related quality of life (HRQoL), as well as good metabolic control.

Reproductive character displacement occurs when competition for successful breeding imposes a divergent selection on the interacting species, causing a divergence of reproductive traits. Here, we show that a disputed butterfly taxon is actually a case of male wing colour shift, apparently produced by reproductive character displacement. Using double digest restriction-site associated DNA sequencing and mitochondrial DNA sequencing we studied four butterfly taxa of the subgenus Cupido (Lepidoptera: Lycaenidae): Cupido minimus and the taxon carswelli, both characterized by brown males and females, plus C. lorquinii and C. osiris, both with blue males and brown females. Unexpectedly, taxa carswelli and C. lorquinii were close to indistinguishable based on our genomic and mitochondrial data, despite displaying strikingly different male coloration. In addition, we report and analysed a brown male within the C. lorquinii range, which demonstrates that the brown morph occurs at very low frequency in C. lorquinii. Such evidence strongly suggests that carswelli is conspecific with C. lorquinii and represents populations with a fixed male brown colour morph. Considering that these brown populations occur in sympatry with or very close to the blue C. osiris, and that the blue C. lorquinii populations never do, we propose that the taxon carswelli could have lost the blue colour due to reproductive character displacement with C. osiris. Since male colour is important for conspecific recognition during courtship, we hypothesize that the observed colour shift may eventually trigger incipient speciation between blue and brown populations. Male colour seems to be an evolutionarily labile character in the Polyommatinae, and the mechanism described here might be at work in the wide diversification of this subfamily of butterflies., European Regional Development Fund. Grant Numbers: CGL2016‐76322‐P, PID2019‐107078GB‐I00 Ministerio de Economía, Industria y Competitividad, Gobierno de España. Grant Number: BES‐2017‐080641 Ministerio de Ciencia, Innovación y Universidades Generalitat de Catalunya. Grant Number: 2017‐SGR‐991 Academy of Finland. Grant Number: 328895

The Mars Environmental Dynamics Analyzer (MEDA) is a meteorological station onboard Mars 2020 that characterizes the near surface atmosphere. Among other sensors MEDA has 5 Air Temperature Sensors (ATS) at two altitudes: 0.85m, in the front of the rover, and 1.45m around the Remote Sensing Mast, which are azimuthally distributed so that at least one sensor is located upwind. This configuration ensures that, for most environmental conditions, the thermal contamination caused by the rover can be set apart. Local air temperatures are read with a frequency of 1 or 2 Hz, and ATS data can characterize timescales from atmospheric turbulence to the daily temperature cycle and its seasonal evolution. Here we show the daily temperature cycle at Jezero and an analysis of its seasonal evolution over the first half Martian year of the mission from Spring (Ls=6) to Autumn Equinox (Ls=180). Simultaneous ATS and winds from MEDA’s wind sensors show that, for most rover orientations, solar irradiation and winds clean environmental measurements are obtained at the 1.45m level. However, clean measurements at the 0.85m level are not always fully achieved, and a small residual thermal contamination is found at this level in many measurement sessions. The daily temperature cycle reflects the daily cycle of convection and turbulence. Strong and fast thermal oscillations start a few hours after sunrise, peak near noon, and collapse before sunset. The seasonal evolution shows a progressive increase of temperatures as summer advances, but less steep than what is retrieved at other Martian locations by previous missions. At the 0.85m level, changes in atmospheric temperatures with time-scales of a few sols correlate well with variations in local terrain properties. At the 1.45m level, similar temperature changes with timescales of a few sols are also found. We investigate whether these changes at 1.45m can be associated with changing atmospheric opacity due to dust and clouds, which are measured by other MEDA sensors and additional instruments in Perseverance. From the two altitudes sampled with ATS, and additional data from the MEDA Thermal InfraRed Sensors (TIRS), which measure ground temperature and air temperature at 40m, we can obtain the near-surface vertical temperature profile for specific sols in which thermal contamination is moderate in all sensors. This allows us to study the evolution of the diurnal convective cycle and the vertical temperature gradient. In addition, the Supercam microphone can also deduce the average air temperature from the ground up to 2.1m high thanks to sound speed measurements during Supercam’s laser zapping rocks. Therefore, it gives an additional hint into the thermal gradient. Furthermore, the amplitude of the thermal oscillations characterizes the thermal turbulence and we present the spectra of turbulence for convective and non convective hours on different moments of the mission. Finally, we will show how the measured thermal data compares with model predictions of the daily cycle of temperatures, expected magnitude of thermal oscillations, and the seasonal evolution.

The Mars 2020 Perseverance rover landed in Mars in February 2021 in Jezero crater at 18.4ºN. One of its instruments is MEDA, the Mars Environmental Dynamics Analyzer, which measures among other properties air pressure, air temperature at different levels, surface temperature from its infrared emission, and the presence of dust. The latter is provided by a set of photodiodes pointing in different directions that constitute the Remote Dust Sensor or RDS. MEDA data are acquired with a frequency of 1 or 2 Hz in data sessions that cover about 50% of a full sol allowing a full characterization of daily and seasonal cycles.Predictions before landing indicated that Jezero should be a location favoring the formation of intense vortices and dust devils in Spring to Summer. These expectations were fulfilled with frequent observations of vortices and dust devils observed with MEDA and the rover cameras. A systematic analysis of MEDA’s pressure sensor shows the close passage of convective vortices. These are detected as events that range from short and sharp pressure drops to long and deep pressure drops. Wind measurements during the vortex passage, combined with their duration, give information about the size and distance of the vortex. Many of the most intense events in terms of the pressure drop and peak winds detected have simultaneous drops of light measured with the RDS and are dust devils equivalent to those observed at much higher distances with Perseverance cameras. The combination of pressure, wind and RDS measurements largely constrain the geometry effects associated to these close passing dust devils. Some of them also have additional clear counterparts in other MEDA sensors including temperatures, which allows for an in-depth investigation of the physical properties of selected dust devils. Some events might also be captured by the SuperCam microphone, that records pressure fluctuations in the audible domain. The acoustic signal can provide insights into the short term behavior of vortices, and can contribute to the determination of the vortex physical properties. Statistics of vortices allow us to determine the probability of finding these events with the SuperCam microphone.We present results for over one Earth year (Ls=6; Feb. 2021, Northern Hemisphere Spring – Ls=180; Feb. 2022; Northern Autumn Equinox). We show the daily cycle of vortex and dust devil activity and how this has evolved from early Spring until the start of the dust storms season. We present results of the distribution of sizes of vortices and dust devils and a selection of some remarkable events. These include direct hits of dust devils passing right through Perseverance, tangential passes in which one wall of the vortex passes over Perseverance, and more distant passages of very dusty events whose diameter in some cases largely exceed 100 m. A comparison of the vortex convective activity observed at Jezero with results from a Large-Eddy-Simulations (LES) using the MarsWRF model helps us to gain insight into how the detected vortices and their properties can constrain other general properties of the atmospheric dynamics at Jezero crater.

NASA’s Mars 2020 Perseverance rover landed in Jezero Crater (~18.4ºN, 77.6ºE) on February 2021 at Ls~5º, just after the northern spring equinox. Perseverance carries the Mars Environmental Dynamics Analyzer (MEDA) instrument [1], which includes a wind sensor that is a heritage from previous sensors sent to Mars as part of the Mars Science Laboratory (MSL) and InSight missions. Those sensors allowed the characterization of the near-surface wind patterns at Gale Crater [2] and Elysium Planitia [3,4]. The wind sensor of MEDA is allowing near-surface wind patterns to be characterized at Perseverance’s landing site, thus complementing the data acquired by previous missions on the surface of Mars.Previous missions at different locations on the Martian surface observed a contribution by several mechanisms from different scales involved in the near-surface winds, including the effect of local and regional slope winds induced by topography, thermal tides, baroclinic waves and the Hadley cell, each one with a variable weight on the resulting wind patterns as a function of location, season and the presence of dust storms (e.g. [2-4] and references therein). The near-surface wind data acquired by Mars 2020 show a complex dynamics at Jezero Crater, as predicted by models (e.g. [5]). Preliminary interpretation suggests that the diurnal cycle of winds is dominated by the regional circulation mainly forced by slope winds in the Isidis basin region, which interact with the local scale circulation at Jezero and Hadley cell flows. The potential contribution by these mechanisms on the resulting wind patterns measured at Mars2020’s landing site will be presented, with a further focus on the observed wind variability supported by probabilistic models. References:[1] Rodriguez-Manfredi et al. (2021), SSR, 217(48). [2] Viúdez-Moreiras et al. (2019), Icarus, 319, 909-925. [3] Banfield et al. (2020), Nat.Geo, 13, 190-198. [4] Viúdez-Moreiras et al. (2020) JGR-Planets, 125, e2020JE006493. [5] Newman et al. (2021) SSR, 217(20).

INTRODUCTION: The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call. METHODS: CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality. RESULTS: This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients. CONCLUSIONS: We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs.

On top of listening to laser shots, rover sounds and the Ingenuity rotorcraft, SuperCam’s Mars microphone has recorded over 7 hours of ambient background noise on Mars. These background recordings contain signal due to the Martian wind. Through a comparison to the meteorological data recorded by the MEDA (Mars Environmental Dynamics Analyzer), we can determine the relationships between the microphone data, the wind and the atmospheric stability. Based on these relationships, we have determined a way to estimate the wind speed using the microphone through Gaussian process regression, a machine learning technique. Owing to the sampling rate of 25 000 samples per second, the microphone data can be used to examine Mars’ atmospheric dynamics at high frequencies, as yet unexplored on Mars. We will demonstrate how the wind speed estimates from the microphone provide an assessment of turbulence at fine scales, shedding light on the dissipative regime on Mars. One particularly interesting signal recorded by the microphone was a dust devil, which had fast varying winds within the walls of its vortex and signal from dust particles hitting the rover. Combining the microphone data with information from the MEDA sensors and navigation camera (Navcam) images enabled a full parameterization of this event.

Since 2018, Spanish National Immunization Guidelines include vaccination recommendations for adults ≥65 years. To determine whether health-care professionals and the ≥65 years target group value the need for these recommendations, a cross-sectional study was conducted to capture and describe their knowledge, attitudes, beliefs and behaviors about vaccination. Online surveys were administered to representative groups of general practitioners (GPs), primary care nurses and adults ≥65 years from six major cities (and surrounding rural areas) in Spain. Main topics were attitudes and awareness of vaccines, perceptions about vaccination in adults ≥65 years, and impact of the COVID-19 pandemic on vaccination uptake. A total of 286 health-care professionals (185 GPs, 101 nurses) and 400 adults aged ≥65 years participated in the survey. GP and nurse groups agreed strongly about the importance of influenza and pneumococcal vaccination in the target population. Longer patient visit times were identified as a key factor toward promoting vaccination. The ≥65 years sample group, especially those ≥75+ years and/or with chronic diseases, was reasonably positive about the effectiveness and benefits of vaccines. Lower vaccination rates for the pneumococcal than influenza vaccine (29% vs. 80%) in the ≥65 years sample group suggest that efforts are needed to improve pneumococcal vaccine uptake. Aligning with other published works, GPs have a key role in promoting vaccination in the target population. The COVID-19 pandemic appears to have heightened awareness about the importance of vaccination among health-care professionals and adults ≥65 years.

Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19. Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. The primary outcome was 90-day mortality. Subsequent analyses in clinically relevant subgroups by age, ICU baseline illness severity, organ damage, laboratory findings and mechanical ventilation were performed. High doses of corticosteroids (≥ 12 mg/day equivalent dexamethasone dose), early administration of corticosteroid treatment (< 7 days since symptom onset) and long term of corticosteroids (≥ 10 days) were also investigated. Results: Between February 2020 and October 2021, 4226 patients were included. Of these, 3592 (85%) patients had received systemic corticosteroids during hospitalisation. In the propensity-adjusted multivariable analysis, the use of corticosteroids was protective for 90-day mortality in the overall population (HR 0.77 [0.65-0.92], p = 0.003) and in-hospital mortality (SHR 0.70 [0.58-0.84], p < 0.001). Significant effect modification was found after adjustment for covariates using propensity score for age (p = 0.001 interaction term), Sequential Organ Failure Assessment (SOFA) score (p = 0.014 interaction term), and mechanical ventilation (p = 0.001 interaction term). We observed a beneficial effect of corticosteroids on 90-day mortality in various patient subgroups, including those patients aged ≥ 60 years; those with higher baseline severity; and those receiving invasive mechanical ventilation at ICU admission. Early administration was associated with a higher risk of 90-day mortality in the overall population (HR 1.32 [1.14-1.53], p < 0.001). Long-term use was associated with a lower risk of 90-day mortality in the overall population (HR 0.71 [0.61-0.82], p < 0.001). No effect was found regarding the dosage of corticosteroids. Moreover, the use of corticosteroids was associated with an increased risk of nosocomial bacterial pneumonia and hyperglycaemia. Conclusion: Corticosteroid in ICU-admitted patients with COVID-19 may be administered based on age, severity, baseline inflammation, and invasive mechanical ventilation. Early administration since symptom onset may prove harmful. Instituto de Salud Carlos III de Madrid (ISCIII) (COV20/00110) Centro de Investigacion Biomedica En Red-Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III European Commission Miguel Servet 2020: CP20/00041 Instituto de Salud Carlos III (PI19/00207) 41.787 JCR (2022) Q1, 2/35 Critical Care Medicine 4.344 SJR (2022) Q1, 2/98 Critical Care and Intensive Care Medicine No data IDR 2022 UEM

Supplemental material, sj-docx-6-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services

We estimated the potential impact of Global Warming on the species richness of Iberian butterflies. First, we determined the grid size that maximized the balance between geographic resolution, area coverage and environmental representativeness. Contemporary richness was modelled in several alternative ways that differed in how sampling effort was controlled for, and in whether the non-climatic variables (physiography, lithology, position) were incorporated. The results were extrapolated to four WorldClim scenarios. Richness loss is to be expected for at least 70% of the area, with forecasts from the combined models being only slightly more optimistic than those from the purely climatic ones. Overall, the most intense losses are predicted for areas of highest contemporary species richness, while the potential slightly positive or nearly neutral changes would most often concentrate in cells of low to moderate present richness. The environmental determinants of richness might not be uniform across the geographical range of sampling effort, suggesting the need of additional data from the least intensively surveyed areas., Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was partly funded by JJ CC Castilla—La Mancha (Spain), Project SBPLY/17/180501/000492 and MINECO, Project CGL2017-86926-P

Supplemental material, sj-docx-4-joh-10.1177_00207314211012357 for Impact of the Economic Crisis on Endocarditis Mortality in Spain: A Nationwide Study by Christian Ortega-Loubon, Gema Ruiz López del Prado, María F. Muñoz-Moreno, Esther Gómez-Sánchez, Rocío López-Herrero, Belén Sánchez-Quirós, Mario Lorenzo-Lopez, Estefanía Gómez-Pesquera, Pablo Jorge-Monjas, Juan Bustamante-Munguira, F. Javier Álvarez, Salvador Resino, Eduardo Tamayo and María Heredia-Rodríguez in International Journal of Health Services