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Multi-touch technology is increasingly being used to support collaborative learning activities. However, to know how this technology can be used most effectively, we need to understand if collaborative interactions differ when groups are using multi-touch technology compared with other tools. In this paper, we compare the interactions of groups of 10 to 11-year-old students working collaboratively to solve three math problems in either a multi-touch or paper condition. The number of ideas raised, who proposed them and whether they were responded to, were coded to identify differences in idea development and interactions across conditions. Responses by students to ideas proposed by other students were coded. Results indicate that similar numbers of ideas were raised across conditions; student responses to ideas raised by other students were more likely to elaborate on the idea or combine it with other ideas in the multi-touch condition than in the paper condition. These results reinforce prior findings that show higher levels of collaborative engagement around ideas when using multi-touch than paper and extend our understanding of how this occurs.

Self-care is essential in the long-term management of chronic heart failure. Heart failure guidelines stress the importance of patient education on treatment adherence, lifestyle changes, symptom monitoring and adequate response to possible deterioration. Self-care is related to medical and person-centred outcomes in patients with heart failure such as better quality of life as well as lower mortality and readmission rates. Although guidelines give general direction for self-care advice, health care professionals working with patients with heart failure need more specific recommendations. The aim of the management recommendations in this paper is to provide practical advice for health professionals delivering care to patients with heart failure. Recommendations for nutrition, physical activity, medication adherence, psychological status, sleep, leisure and travel, smoking, immunization and preventing infections, symptom monitoring, and symptom management are consistent with information from guidelines, expert consensus documents, recent evidence and expert opinion. Jaarsma, T (corresponding author), Univ Linkoping, Fac Hlth Sci, Kungsgatan 40, S-60174 Norrkoping, Sweden. tiny.jaarsma@liu.se

The selective recognition of tyrosine residues in peptides is an appealing approach to inhibiting their tyrosine kinase (TK)‐mediated phosphorylation. Herein, we describe pseudopeptidic cages that efficiently protect substrates from the action of the Src TK enzyme, precluding the corresponding Tyr phosphorylation. Fluorescence emission titrations show that the most efficient cage inhibitors strongly bind the peptide substrates with a very good correlation between the binding constant and the inhibitory potency. Structural insights and additional control experiments further support the proposed mechanism of selective supramolecular protection of the substrates. Moreover, the approach also works in a completely different kinase‐substrate system. These results illustrate the potential of supramolecular complexes for the efficient and selective modulation of TK signaling., How to spare Tyr: The selective recognition of tyrosine residues by pseudopeptidic cages protects the substrates from Src kinase‐promoted phosphorylation. The Tyr kinase‐inhibiting activity of the cages can be satisfactorily explained by the formation of host‐guest complexes. This supramolecular approach represents an appealing alternative to modulating Tyr kinase activity by substrate recognition.

A comparative study on the self‐assembly of sexiphenyl‐dicarbonitrile on highly oriented pyrolytic graphite and single‐layer graphene on Cu(111) is presented. Despite an overall low molecule–substrate interaction, the close‐packed structures exhibit a peculiar shift repeating every four to five molecules. This shift has hitherto not been reported for similar systems and is hence a unique feature induced by the graphitic substrates.

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Furthermore, genetic predisposition and clonal haematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Additionally, altered angiogenesis is a common hallmark for failing hearts and tumours and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the two pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. To this aim, pre‐clinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including patients from all ages, and men and women, with proper adjudication of both cancer and cardiovascular endpoints, are essential to accurately study these two pathologies at the same time., We describe the co‐occurrence of cancer and heart failure (HF), their potential shared risk factors, and their pathophysiological mechanisms. We advocate intense interaction between cardiologists and oncologists to achieve unifying hypotheses and collaborative pre‐clinical and clinical studies.

Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of high levels of advanced glycation end products (AGEs), particularly upon aging. AGEs form when sugars or their metabolites react with proteins. Associated with a myriad of age‐related diseases, AGEs accumulate in many tissues and are cytotoxic. To date, efforts to limit glycation pharmacologically have failed in human trials. Thus, it is crucial to identify systems that remove AGEs, but such research is scanty. Here, we determined if and how AGEs might be cleared by autophagy. Our in vivo mouse and C. elegans models, in which we altered proteolysis or glycative burden, as well as experiments in five types of cells, revealed more than six criteria indicating that p62‐dependent autophagy is a conserved pathway that plays a critical role in the removal of AGEs. Activation of autophagic removal of AGEs requires p62, and blocking this pathway results in accumulation of AGEs and compromised viability. Deficiency of p62 accelerates accumulation of AGEs in soluble and insoluble fractions. p62 itself is subject to glycative inactivation and accumulates as high mass species. Accumulation of p62 in retinal pigment epithelium is reversed by switching to a lower glycemia diet. Since diminution of glycative damage is associated with reduced risk for age‐related diseases, including age‐related macular degeneration, cardiovascular disease, diabetes, Alzheimer's, and Parkinson's, discovery of methods to limit AGEs or enhance p62‐dependent autophagy offers novel potential therapeutic targets to treat AGEs‐related pathologies., AGEs are toxic compounds formed by non‐enzymatic reactions between sugars and proteins. AGEs are prone to aggregate. Insoluble AGEs are efficiently removed via p62‐selective autophagy. The autophagic removal of AGEs is a conserved pathway, and the lack of p62 leads to accumulation of toxic AGEs in mouse and worms. Enhanced autophagy is protective against glycation‐derived damage. p62‐dependent autophagy offers novel potential therapeutic targets to treat AGEs‐related pathologies.

The solution of a structure of human Rab27a suffering from severe anisotropy and translational noncrystallographic symmetry was aided by identifying diffraction measurements with low information content., Data pathologies caused by effects such as diffraction anisotropy and translational noncrystallographic symmetry (tNCS) can dramatically complicate the solution of the crystal structures of macromolecules. Such problems were encountered in determining the structure of a mutant form of Rab27a, a member of the Rab GTPases. Mutant Rab27a constructs that crystallize in the free form were designed for use in the discovery of drugs to reduce primary tumour invasiveness and metastasis. One construct, hRab27aMut, crystallized within 24 h and diffracted to 2.82 Å resolution, with a unit cell possessing room for a large number of protein copies. Initial efforts to solve the structure using molecular replacement by Phaser were not successful. Analysis of the data set revealed that the crystals suffered from both extreme anisotropy and strong tNCS. As a result, large numbers of reflections had estimated standard deviations that were much larger than their measured intensities and their expected intensities, revealing problems with the use of such data at the time in Phaser. By eliminating extremely weak reflections with the largest combined effects of anisotropy and tNCS, these problems could be avoided, allowing a molecular-replacement solution to be found. The lessons that were learned in solving this structure have guided improvements in the numerical analysis used in Phaser, particularly in identifying diffraction measurements that convey very little information content. The calculation of information content could also be applied as an alternative to ellipsoidal truncation. The post-mortem analysis also revealed an oversight in accounting for measurement errors in the fast rotation function. While the crystal of mutant Rab27a is not amenable to drug screening, the structure can guide new modifications to obtain more suitable crystal forms.

Crystallographic methods are used to identify the primary mineral phase of pseudomorphs of crystals embedded in 3.48 Ga bedded carbonate-chert rocks from the Dresser Formation, Pilbara Craton, Australia. This identification provides valuable information on the chemical environments at the onset of life on Earth., Crystallography has a long history of providing knowledge and methods for applications in other disciplines. The identification of minerals using X-ray diffraction is one of the most important contributions of crystallography to earth sciences. However, when the crystal itself has been dissolved, replaced or deeply modified during the geological history of the rocks, diffraction information is not available. Instead, the morphology of the crystal cast provides the only crystallographic information on the original mineral phase and the environment of crystal growth. This article reports an investigation of crystal pseudomorphs and crystal casts found in a carbonate-chert facies from the 3.48 Ga-old Dresser Formation (Pilbara Craton, Australia), considered to host some of the oldest remnants of life. A combination of X-ray microtomography, energy-dispersive X-ray spectroscopy and crystallographic methods has been used to reveal the original phases of these Archean pseudomorphs. It is found with a high degree of confidence that the original crystals forming in Archean times were hollow aragonite, the high-temperature polymorphs of calcium carbonate, rather than other possible alternatives such as gypsum (CaSO4·2H20) and nahcolite (NaHCO3). The methodology used is described in detail.

Purpose To explore the strategies used by older people living in Ireland to obtain information about community health and social services. Methods A qualitative exploratory design was used. Focus groups (n = 3) were conducted with community dwelling older people (n = 17). A series of vignettes were used to guide discussion regarding hypothetical situations that approximated real-life scenarios for older people. Data were transcribed verbatim and analysed using content analysis. Results Obtaining information about community health and social services is an ongoing process that requires continuous commitment by older adults. Key strategies which emerged from the data included (i) taking a proactive stance towards accessing health information, (ii) making use of personal networks in your community and (iii) developing ‘insider’ knowledge. Conclusion Older people in this study had a proactive approach to obtaining health information and identified the importance of taking responsibility for managing their own needs. Despite this, obtaining basic information about community health and social services was a challenging and time-consuming process. Future research should focus on developing health literacy interventions that build upon and expand the strategies currently used by older people.

Bioconversion of syngas/waste gas components to produce ethanol appears to be a promising alternative compared to the existing chemical techniques. Recently, several laboratory-scale studies have demonstrated the use of acetogens that have the ability to convert various syngas components (CO, CO2, and H2) to multicarbon com- pounds, such as acetate, butyrate, butanol, lactate, and ethanol, in which ethanol is often produced as a minor end- product. This bioconversion process has several advantages, such as its high specifi city, the fact that it does not require a highly specifi c H2/CO ratio, and that biocatalysts are less susceptible to metal poisoning. Furthermore, this process occurs under mild temperature and pressure and does not require any costly pre-treatment of the feed gas or costly metal catalysts, making the process superior over the conventional chemical catalytic conversion process. The main challenge faced for commercializing this technology is the poor aqueous solubility of the gaseous sub- strates (mainly CO and H2). In this paper, a critical review of CO-rich gas fermentation to produce ethanol has been analyzed systematically and published results have been compared. Special emphasis has been given to under- stand the microbial aspects of the conversion process, by highlighting the role of different micro-organisms used, pathways, and parameters affecting the bioconversion. An analysis of the process fundamentals of various bioreac- tors used for the biological conversion of CO-rich gases, mainly syngas to ethanol, has been made and reported in this paper. Various challenges faced by the syngas fermentation process for commercialization and future research requirements are also discussed. © 2011 Society of Chemical Industry and John Wiley & Sons, Ltd

Summary Insect pollinators are essential for both the production of a large proportion of world crops and the health of natural ecosystems. As important pollinators, bumblebees must learn to forage on flowers to feed both themselves and provision their colonies.Increased use of pesticides has caused concern over sublethal effects on bees, such as impacts on reproduction or learning ability. However, little is known about how sublethal exposure to field‐realistic levels of pesticide might affect the ability of bees to visit and manipulate flowers.We observed the behaviour of individual bumblebees from colonies chronically exposed to a neonicotinoid pesticide (10 ppb thiamethoxam) or control solutions foraging for the first time on an array of morphologically complex wildflowers (Lotus corniculatus and Trifolium repens) in an outdoor flight arena.We found that more bees released from pesticide‐treated colonies became foragers, and that they visited more L. corniculatus flowers than controls. Interestingly, bees exposed to pesticide collected pollen more often than controls, but control bees learnt to handle flowers efficiently after fewer learning visits than bees exposed to pesticide. There were also different initial floral preferences of our treatment groups; control bees visited a higher proportion of T. repens flowers, and bees exposed to pesticide were more likely to choose L. corniculatus on their first visit.Our results suggest that the foraging behaviour of bumblebees on real flowers can be altered by sublethal exposure to field‐realistic levels of pesticide. This has implications for the foraging success and persistence of bumblebee colonies, but perhaps more importantly for the interactions between wild plants and flower‐visiting insects and ability of bees to deliver the crucial pollination services to plants necessary for ecosystem functioning.

Summary Declining populations of bee pollinators are a cause of concern, with major repercussions for biodiversity loss and food security. RNA viruses associated with honeybees represent a potential threat to other insect pollinators, but the extent of this threat is poorly understood. This study aims to attain a detailed understanding of the current and ongoing risk of emerging infectious disease (EID) transmission between managed and wild pollinator species across a wide range of RNA viruses. Within a structured large-scale national survey across 26 independent sites, we quantify the prevalence and pathogen loads of multiple RNA viruses in co-occurring managed honeybee (Apis mellifera) and wild bumblebee (Bombus spp.) populations. We then construct models that compare virus prevalence between wild and managed pollinators. Multiple RNA viruses associated with honeybees are widespread in sympatric wild bumblebee populations. Virus prevalence in honeybees is a significant predictor of virus prevalence in bumblebees, but we remain cautious in speculating over the principle direction of pathogen transmission. We demonstrate species-specific differences in prevalence, indicating significant variation in disease susceptibility or tolerance. Pathogen loads within individual bumblebees may be high and in the case of at least one RNA virus, prevalence is higher in wild bumblebees than in managed honeybee populations. Our findings indicate widespread transmission of RNA viruses between managed and wild bee pollinators, pointing to an interconnected network of potential disease pressures within and among pollinator species. In the context of the biodiversity crisis, our study emphasizes the importance of targeting a wide range of pathogens and defining host associations when considering potential drivers of population decline.

Analysis of maximum depth of occurrence of 11 952 marine fish species shows a global decrease in species number (N) with depth (x; m): log10 N = -0·000422x + 3·610000 (r(2) = 0·948). The rate of decrease is close to global estimates for change in pelagic and benthic biomass with depth (-0·000430), indicating that species richness of fishes may be limited by food energy availability in the deep sea. The slopes for the Classes Myxini (-0·000488) and Actinopterygii (-0·000413) follow this trend but Chondrichthyes decrease more rapidly (-0·000731) implying deficiency in ability to colonize the deep sea. Maximum depths attained are 2743, 4156 and 8370 m for Myxini, Chondrichthyes and Actinopterygii, respectively. Endemic species occur in abundance at 7-7800 m depth in hadal trenches but appear to be absent from the deepest parts of the oceans, >9000 m deep. There have been six global oceanic anoxic events (OAE) since the origin of the major fish taxa in the Devonian c. 400 million years ago (mya). Colonization of the deep sea has taken place largely since the most recent OAE in the Cretaceous 94 mya when the Atlantic Ocean opened up. Patterns of global oceanic circulation oxygenating the deep ocean basins became established coinciding with a period of teleost diversification and appearance of the Acanthopterygii. Within the Actinopterygii, there is a trend for greater invasion of the deep sea by the lower taxa in accordance with the Andriashev paradigm. Here, 31 deep-sea families of Actinopterygii were identified with mean maximum depth >1000 m and with >10 species. Those with most of their constituent species living shallower than 1000 m are proposed as invasive, with extinctions in the deep being continuously balanced by export of species from shallow seas. Specialized families with most species deeper than 1000 m are termed deep-sea endemics in this study; these appear to persist in the deep by virtue of global distribution enabling recovery from regional extinctions. Deep-sea invasive families such as Ophidiidae and Liparidae make the greatest contribution to fish fauna at depths >6000 m.

The addition of hexafluoridophosphate salts (ammonium, silver, thallium or potassium) is usually used to precipitate complex cations from aqueous solutions. It has long been known that PF6− is sensitive towards hydrolysis under acidic conditions [Gebala & Jones (1969). J. Inorg. Nucl. Chem. 31, 771–776; Plakhotnyk et al. (2005). J. Fluorine Chem. 126, 27–31]. During the course of our investigation into coinage metal complexes of diphosphine ligands, we used ammonium hexafluoridophosphate in order to crystallize [Ag(diphosphine)2]PF6 complexes. From these solutions we always obtained needle-like crystals which turned out to be the title compound, 2NH4+·HPO42−. It was received as the hydrolysis product of NH4PF6. The crystals are a new modification of diammonium hydrogen phosphate. In contrast to the previously published polymorph [Khan et al. (1972). Acta Cryst. B28, 2065–2069], Z′ of the title compound is 2. In the new modification of the title compound, there are eight molecules of (NH4)2(HPO4) in the unit cell. The structure consists of PO3OH and NH4 tetrahedra, held together by O—H...O and N—H...O hydrogen bonds.

In the crystal structure of the title compound, [WCl(2)(NO)(C(6)H(16)P(2))(2)]Cl, the seven-coordinated tungsten(II) center displays a distorted penta-gonal-bipyramidal geometry with trans nitrosyl and chloride ligands. The NO and Cl ligands are disordered over two positions; the site occupancy factors are 0.6 and 0.4.

The carbazole unit of the title molecule, C13H13NO2, is not planar. The dihedral angle between the benzene ring and the pyrrole ring is 1.69 (6)°. The cyclohexene ring adopts an envelope conformation. Intermolecular C—H...O and N—H...O hydrogen bonds are present in the crystal structure. A C—H...π interaction, involving the benzene ring, is also found in the crystal structure.

In the title compound, C26H27NO3, the piperidine ring adopts a chair conformation. The two methoxyphenyl groups attached to the piperidine ring at positions 2 and 6 have equatorial orientations and make a dihedral angle of 87.33 (8)°. The benzyl group at position 3 has an equatorial orientation. The phenyl ring of the benzyl group makes dihedral angles of 75.60 (9) and 73.69 (9)° with the two benzene rings. Molecules are linked by intermolecular N—H...O and C—H...O hydrogen bonds and by C—H...π interactions.

Aims: The suitability of genetic fingerprinting to study the microbiological basis of anaerobic bioreactor failure is investigated. Methods and Results: Two laboratory-scale anaerobic expanded granular sludge bed bioreactors, R1 and R2, were used for the mesophilic (37°C) treatment of high-strength [10 g chemical oxygen demand (COD) l−1] synthetic industrial-like wastewater over a 100-day trial period. A successful start up was achieved by both bioreactors with COD removal over 90%. Both reactors were operated under identical parameters; however, increased organic loading during the trial induced a reduction in the COD removal of R1, while R2 maintained satisfactory performance (COD removal >90%) throughout the experiment. Specific methanogenic activity measurements of biomass from both reactors indicated that the main route of methane production was hydrogenotrophic methanogenesis. Terminal restriction fragment length polymorphism (TRFLP) analysis was applied to the characterization of microbial community dynamics within the system during the trial. The principal differences between the two consortia analysed included an increased abundance of Thiovulum- and Methanococcus-like organisms and uncultured Crenarchaeota in R1. Conclusions: The results indicated that there was a microbiological basis for the deviation, in terms of operational performance, of R1 and R2. Significance and Impact of the Study: High-throughput fingerprinting techniques, such as TRFLP, have been demonstrated as practically relevant for biomonitoring of anaerobic reactor communities.

7 pages, 8 figures, 1 table.-- Printed version published Apr 2003., Black liquors from a soda pulping mill were treated with the white-rot fungus Trametes versicolor to detoxify and reduce colour, aromatic compounds and chemical oxygen demand (COD). The fungus was used in the form of pellets in aerated reactors (fluidized, stirred and air-pulsed reactors). Reductions in colour and aromatic compounds of 70-80% and in COD of 60% were achieved. During the different experiments, laccase activity was detected but neither lignin peroxidase (LiP) nor manganese peroxidase activities were detected, although T versicolor is able to produce these enzymes. Experiments also showed a LiP activity inhibitory effect produced by lignin. From the results obtained, it can be concluded that there is a relationship between laccase production and toxicity reduction. This correlation responds to the equation Laccase production = 1.57 LN (toxicity reduction) -16.40. Copyright © 2003 Society of Chemical Industry, Financial support from CICYT in the framework of Project AMB 94-0287 and CIRIT through the Unitat d'Enginyeria Bioquímica of the Centre de Referència en Biotecnología (Generalitat de Catalunya).

Freezing preservation of banana (Musa cavendishii, var. enana) was investigated. Microwave treatment of banana slices at 650 watts for 2 min or immersion of whole peeled fruits in boiling water for 11 min followed by freezing at -24°C inhibited color deterioration in the frozen product. Treatments showed different effectiveness depending on the enzymatic system studied [polyphenoloxidase (PPO) or peroxidase (POD)] and banana maturity level at the processing date. Blanching in boiling water yielded a good frozen product in which no darkening was observed. The proper stage of ripeness for processing of this banana cultivar was characterized by a firmness of 1.24 kg, a pulp/skin ratio of 1.30 and a green (70%)-yellow (30%) peel color.

While natural photosynthesis serves as the model system for efficient charge separation and decoupling of redox reactions, bio‐inspired artificial systems typically lack applicability owing to synthetic challenges and structural complexity. We present herein a simple and inexpensive system that, under solar irradiation, forms highly reductive radicals in the presence of an electron donor, with lifetimes exceeding the diurnal cycle. This radical species is formed within a cyanamide‐functionalized polymeric network of heptazine units and can give off its trapped electrons in the dark to yield H2, triggered by a co‐catalyst, thus enabling the temporal decoupling of the light and dark reactions of photocatalytic hydrogen production through the radical′s longevity. The system introduced here thus demonstrates a new approach for storing sunlight as long‐lived radicals, and provides the structural basis for designing photocatalysts with long‐lived photo‐induced states.

Este artículo está sujeto a una licencia CC BY-NC 4.0, This article analyses the review, acceptance and publication dates of a sample of 21,890 articles from 326 Ibero-American scientific journals from all subject areas and countries included in the Latindex Catalogue 2.0 and published between 2018 and 2020 (freely available as an open access dataset). The aim is to discover evaluation and publication times. The evaluation process takes a median of 110 days, the publication process, a median of 82 days, and the whole process, a median of 224 days. Statistical differences are found according to periodicity, subject areas, countries, existence of a printed version and article type (Call for Papers or General articles). From the data we find that the delay in publication is longer than publishers themselves report to the DOAJ. STEM areas present the most similarity in publication patterns, having a higher number of evaluation days (Ed) than publication days (Pd); Arts and Humanities present the opposite pattern, with a higher Pd than Ed. In the case of Social Sciences, the times are similar. General articles and Call for Papers articles differ in terms of Ed, but not Pd, indicating that Call for Papers revisions are faster.

It remains unclear how effective COVID-19 vaccinations will be in patients with weakened immunity due to diseases, transplantation, and dialysis. We conducted a systematic review comparing the efficacy of COVID-19 vaccination in patients with solid tumor, hematologic malignancy, autoimmune disease, inflammatory bowel disease, and patients who received transplantation or dialysis. A literature search was conducted twice using the Medline/PubMed database. As a result, 21 papers were included in the review, and seropositivity rate was summarized by specific type of disease, transplantation, and dialysis. When different papers studied the same type of patient group, a study with a higher number of participants was selected. Most of the solid tumor patients showed a seropositivity rate of more than 80% after the second inoculation, but a low seropositivity was found in certain tumors such as breast cancer. Research in patients with certain types of hematological malignancy and autoimmune diseases has also reported low seropositivity, and this may have been affected by the immunosuppressive treatment these patients receive. Research in patients receiving dialysis or transplantation has reported lower seropositivity rates than the general population, while all patients with inflammatory bowel disease have converted to be seropositive. Meta-analysis validating these results will be needed, and studies will also be needed on methods to protect patients with reduced immunity from COVID-19. This article is protected by copyright. All rights reserved.

This research surveys changing attitudes to drawing pedagogy, in the context of digitisation, moves toward student-centred learning in Art and Design Higher Education, and anecdotal reports of declining competence. Based on student, teacher and examiner’s experiences, it has been possible to gain insights into how drawing instruction has changed over the past generation. This paper examines the attitudes, values and concerns of students and educators regarding drawing instruction. The study reveals that, in the UK, drawing skills are considered to be gradually declining, while traditional notions of skill are called into question. Drawing as a means of visual recording, representation and communication remains valued, although no longer essential as it once was; while drawing to augment thought process, is increasingly recognised as an integral skill which enables innovation. The latter is rarely ‘taught’ but relies on core competencies that many lecturers fear are being eroded. Increasing value is placed on drawing ‘as process’, while provision is moving towards individualised instruction requiring students to work independently. While new technologies are a factor, this paper re-frames the issue as an imbalance between creative outcomes and creative process, with a disparity between school and university levels. This paper calls for a renewed emphasis on ‘drawing as process’ as preparation for university, and for further consideration of the core competencies underpinning the use of drawing as a tool of thought, and how these might be standardised.

1. In a previous series of papers (Sutherland et al., 2018), we summarise the use of a range of social science methods in conservation decision making. Moon et al. (submitted) claim that the special issue risks narrowing the scope of social science research and suggest that we presented a limited perspective on the field. They thereby criticise the special issue for not doing something that it never intended to do in the first instance. We did not claim that the list of articles covered in the special issue is a comprehensive list (which it obviously is not) and we are unclear why anyone would think it is. 2. While we consider the Moon et al. (submitted) paper to be a useful contribution for conservation scientists as a supplementary paper, it serves less as a critique to the special issue. Moon et al.’s (submitted) paper makes very few direct and substantive criticisms of points raised in the special issue. We respond to areas of contention referring specifically to research philosophy, bias, and data reporting. 3. Moon et al. (submitted) criticise the set of papers for perpetuating an objectivist view of the world. We believe that it would be rather disconcerting for the research community if there were no social truths to discover. Rather, social science research methods conducted in specific places can be good ways of exploring how truths vary in different contexts. 4. We also note that Moon et al. (submitted) completely missed the point we were trying to make about psychological biases, which are quite different to the issues associated with researcher bias highlighted by them. 5. We encourage readers to pay close attention to the use of social science methods in conservation science. We reiterate, however, that the main purpose of the special issue was to ensure that social science methodologies for decision making are accessible for all conservation scientists to use, regardless of disciplinary background.

This paper investigates the determinants of internal mobility across Spanish provinces of both foreigners and natives over the decade 2004-14. Building on an extended gravity model, our econometric strategy controls for multilateral resistance to migration by including different fixed effects structures. Additionally, the paper allows for some nonlinearities in the key economic determinants of migration, wages and unemployment. The main finding is that the impact of economic factors on internal migration is higher for foreigners than for natives; furthermore, the effect of these factors on internal migration is clearly nonlinear for the group of natives, while this only happens for foreigners when dyadic fixed effects of origin-destination are considered. Finally, the paper shows that the nature of the amenities with the greatest impact on internal movements differs between the two groups: foreigners look for social services and cultural amenities, whereas natives are more attracted by good climate conditions.

The Galileo E6 band operates at a nonprimary frequency band within the L-band. This presents challenging situations in the vicinity of other, legitimate, radiolocation services. This is the case for Air Traffic Control (ATC) radar, which is seen as an in-band–pulsed interference by a GNSS receiver. This paper provides a detailed study of the impact of such interference, as well as localization approaches. Particularly, the paper describes the ATC jamming event captured on a GNSS permanent station, its effects on a real receiver, and how it was tracked to localize the source of interference. An ultra low-cost array-based solution is prototyped, based on commercial off-the-shelf devices, that implements a two-element array. Experimental results are shown and discussed using real data, validating the localization performance of the prototype. © 2019 Institute of Navigation

OBJECTIVE: The collection and use of ordinal variables are common in many psychological and psychiatric studies. Although the models for continuous variables have similarities to those for ordinal variables, there are advantages when a model developed for modeling ordinal data is used such as avoiding "floor" and "ceiling" effects and avoiding to assign scores, as it happens in continuous models, which can produce results sensitive to the score assigned. This paper introduces and focuses on the application of the ordered stereotype model, which was developed for modeling ordinal outcomes and is not so popular as other models such as linear regression and proportional odds models. This paper aims to compare the performance of the ordered stereotype model with other more commonly used models among researchers and practitioners. METHODS: This article compares the performance of the stereotype model against the proportional odd and linear regression models, with three, four, and five levels of ordinal categories and sample sizes 100, 500, and 1000. This paper also discusses the problem of treating ordinal responses as continuous using a simulation study. The trend odds model is also presented in the application. RESULTS: Three types of models were fitted in one real-life example, including ordered stereotype, proportional odds, and trend odds models. They reached similar conclusions in terms of the significance of covariates. The simulation study evaluated the performance of the ordered stereotype model under four cases. The performance varies depending on the scenarios. CONCLUSIONS: The method presented can be applied to several areas of psychiatry dealing with ordinal outcomes. One of the main advantages of this model is that it breaks with the assumption of levels of the ordinal response are equally spaced, which might be not true.

This paper investigates a series of glyptic inscriptions attested on Crete at the end of the third and beginning of the second millennium BC, collectively referred to as the ‘Archanes Script’. These minute engravings are considered to represent the earliest appearance of writing west of Egypt, and the first ‘true’ writing in the Aegean. Though mentioned in passing in almost every study of Bronze Age Aegean writing, few scholars have ever offered a definition of what exactly they consider the ‘Archanes Script’ to be. No work or scholarly consensus exists delineating which signs constitute its signary, or even which documents comprise its corpus. Study of the seals as objects in their own right, examining script signs alongside associated iconography, material qualities and form, has been rare. This paper offers the first complete overview and re-definition of the Archanes Script since its discovery in the 1960s and initial definition by Paul Yule in 1980.

This paper explores the identity work practices of Thai Sikh businesspeople. The paper focuses on two important social identities in participants’ self-presentations – those derived from religious (Sikh) and western business discourses – and identifies powerful tensions in their hybrid identity work. Conducting discourse analysis on identity work practices within interview settings, the authors explore how participants resolve, accommodate or reject these discursive tensions while attempting stable and coherent hybrid self-presentations. They identify several different forms of hybridity, including what they term ‘equipollence’, which occurs when two equally powerful, contradictory discourses are incorporated in self-presentations, producing potentially irresolvable intersections and leading to a lack of coherence. Contributions are made to the literatures on religion and work, hybrid identity work processes and social identities.

The focus of this paper is on the Middle Euphrates: Dura-Europos as its best-known urban settlement; a series of villages known mostly from two papyrological dossiers situated along the river; and the military stations on the Euphrates. The paper asks questions about the impact (or lack of it) of the culture of Palmyra on the region's communities. It is argued that Dura-Europos remains our best case study for social and religious life in a Near Eastern small town under the Roman empire, and that the only evidence that actually makes the town look potentially ‘untypical’ is the idiosyncratic source material related to its Palmyrene inhabitants. The paper also questions the traditional periodization of Dura's history and puts forward the hypothesis that at two points during the so-called ‘Parthian phase’ Palmyrenes took advantage of a power vacuum along the Middle Euphrates and became the dominant military factor in the region.

There are tensions within formal education between imparting knowledge and the development of skills for handling that knowledge. In the primary school sector, the latter can also be squeezed out of the curriculum by a focus on basic skills such as literacy and numeracy. What happens when an explicit attempt is made to develop young children's reasoning—both in terms of their apparent cognitive abilities and their basic skills? This paper reports an independent evaluation of an in-class intervention called ‘Philosophy for Children’ (P4C), after just over one year of schooling. The intervention aims to help children become more willing and able to question, reason, construct arguments and collaborate with others. A group of 48 volunteer schools were randomised to receive P4C (22 schools) or act as a control for one year (26). This paper reports the CAT results for all pupils in years 4 and 5 initially, and the Key Stage 2 attainment in English and Maths for those starting in year 5. There was no school dropout. Individual attrition from a total of 3,159 pupils was around 11 percent—roughly equal between groups. There were small positive ‘effect’ sizes in favour of the P4C group in progress in reading (+0.12) and maths (+0.10), and even smaller perhaps negligible improvements in CAT scores (+0.07) and writing (+0.03). The results for the most disadvantaged (free school eligible) pupils were larger for attainment (+0.29 in reading, +0.17 writing and +0.20 maths), but not for CATs (–0.02). Observations and interviews suggest that the intervention was generally enjoyable and thought to be beneficial for pupil confidence. Our conclusion is that, for those wishing to improve attainment outcomes in the short term, an emphasis on developing reasoning is promising, especially for the poorest students, but perhaps not the most effective way forward. However, for those who value reasoning for its own sake, this evaluation demonstrates that using curriculum time in this way does not damage attainment (and may well enhance it and reduce the poverty gradient in attainment), and so suggests that something like P4C is an appropriate educational approach.

Objectives A systematic review was conducted to (1) investigate couple functioning after a pediatric cancer diagnosis and (2) examine theoretical and methodological tendencies and issues in this literature. Methods Searches of Web of Science, PubMed, Cochrane, PsycINFO, and Embase resulted in inclusion of 32 qualitative, quantitative, or mixed-method papers. Findings of these papers were extracted for summary. Results Most couples adapt well to the crisis of a pediatric cancer diagnosis in domains such as emotional closeness, support, marital satisfaction, and general marital adjustment. However, most experience difficulties in the domain of sexual intimacy, and reports on conflict are mixed across qualitative and quantitative studies. Conclusions This review illustrates the need for future research with a greater focus on the impact of a pediatric cancer diagnosis on the couple's functioning, conducted with the use of appropriate theoretical frameworks and based on both partners' reports. Improvements in research are needed to best inform couple-based interventions.

This paper evaluates the outcomes from an ambitious wildflower harvesting programme in South Africa's Western Cape, which has sought to achieve positive outcomes in terms of socio-economic development and biodiversity conservation. Indigenous wildflowers, harvested according to conservation principles, are processed into ‘Cape Flora’ bouquets and sold into international and domestic markets. The principal supply chain provides an example of ethical trade due to the explicit environmental and social standards that are required at local sites of production. The incorporation of such standards represents an attempt to engender economic and social upgrading within the value chain. In this sense, the programme is consistent with dominant policy discourses, which suggest that exploiting potentially profitable niches within international trade flows represents a ‘high road’ to economic growth and transformation. The paper focuses upon the job creation and social impacts of the programme in the context of efforts to overcome South Africa's deeply entrenched socio-economic disparities and high poverty levels. Despite impressive growth in production and exports during the global financial crisis, there have been mixed outcomes in terms of benefits to stakeholders at the upstream end of the supply chain. The paper concludes by considering the extent to which local initiatives operating under the framework of ethical trade possess the potential to facilitate effective social and economic upgrading.

This paper extends existing debate about the relationship between climate change and migration by locating this debate within the registers of race and difference. The paper argues that the discourse on climate change and migration generates a particular racial orientation to climate change called ‘white affect’. To make this argument, the paper connects up two related phenomena: racial neoliberalism and the relationship between affect and biopower. The white affect of climate change and migration discourse is here understood to be an ‘object-target’ of biopolitics. White affect thus becomes an important concept for understanding how racial neoliberalism functions through affective proxy.

The last decade has seen a significant upsurge of studies seeking to examine the impacts of port agents’ strategic decisions. The outcome has been a wide range of results and conclusions. The aim of this work is to provide a review of this recent research in the port industry that uses strategic interaction approaches from industrial organization and game theory. The paper concentrates on five topics: ownership, relationship between ports and their hinterlands, port authorities and port operators’ relations, capacity investment decisions, and port specialization. We present the objectives, methodologies and results of the papers reviewed, with special emphasis on how models are developed. The results are not always consistent between the works analyzed. On the one hand, this could be due to the complexity of the port industry and the high number of agents that intervene. Researchers need to simplify reality to build their models by imposing restrictive assumptions. On the other hand, results could be very sensitive to the techniques used or to the differences on the port environment of the countries of study. However, some conclusions can be extracted and they present a good starting point to develop more sophisticated models. Finally, we also propose avenues for future research.

This paper compares and contrasts state emergency responses to national security crises with responses deployed in a period of economic crisis. Specifically, this paper challenges the appropriateness and legitimacy of the standard emergency response of legislative (as distinct from judicial) deference to the executive when confronting such economic crises. This will be done by questioning the significance in periods of economic crisis of the two principal factors that justify deferring to the executive during a state of emergency pertaining to national security: (i) the necessity of the action taken; and (ii) that the executive has an expertise in decision making in the specific area in question. Ultimately, this paper questions the application of the emergency paradigm to economic crises, arguing that such responses are rarely temporary and instead usher in a ‘new normalcy’.

‘Energy security’ has quickly assumed a significant place in the lexicon of policy. Like other handy couplets for characterising socio-natural relations (such as carrying capacity and resource scarcity), energy security is a powerful framing device: it constructs worlds, normalises certain practices of resource use, and establishes grounds for intervention. In this paper, I explore some of the different ways in which energy (in)security is now being used, and reflect on the political work it currently performs. I highlight the historical conditions under which energy and security have become combined, the close association of energy security with crude oil imports, and the imprint that oil has left on the concept. Although geography has tended to interpret practices of security through either a territorial or biopolitical perspective, in this paper I consider how energy's securitisation proceeds through a set of imaginative and calculative practices (referred to here as ‘geo-metrics’). I use the language of ‘world-making’ to draw attention to the techno-political practices associated with securitising energy, and their capacity for constituting political ecological relations. I illustrate this with reference to a growing body of knowledge and expertise in the calculation and design of energy security indicators.

This paper investigates the impact of exporting and importing on productivity for UK plantsusing a combination of regression and propensity score matching. Unlike earlier papers, the data allows us to distinguish the effects of trade in goods and services. In confirmation of the results from other countries, we find that plants that both export and import have higher productivity than plants that only do one of these activities. In manufacturing, this is the case regardless of whether the trade is in goods or services (which suggests that servitisation of manufacturing is beneficial).In services, the results are more mixed and the benefits from involvement in international goods networks that are seen in manufacturing do not occur to the same extent (however, for the wholesale and retail sectors, trade in both goods and services is generally productivity enhancing).

This essay examines how geography affects the different types of networks underlying social movements. The principal argument of the paper is that networks forged in particular places and at great distances play distinctive yet complementary functions in broad-based social movements. Not only does the articulation of these different types of networks result in complementary roles, but it also introduces key relational dynamics affecting the stability of the entire social movement. The purpose of the paper is therefore threefold: to provide a conceptual framework for interpreting the complex geographies of contemporary social movement networks, to stress the contributions of place-based relations in social movements and to assess how activist places connect to form ‘social movement space’.

This paper shapes and identifies the varieties and dynamics of service economies in the EU 25. By adopting a neo-Schumpeterian and evolutionary approach it contributes to enrich previous research dealing with national disparities from the perspective of services economic structures. Communalities across countries and time are detected and discussed at different levels of analysis. A wide set of models across the European region is found from an aggregated perspective. Moreover, the paper analyses the key dimensions explaining the different service models at sectoral level: structural change, knowledge and innovation, internationalisation and competition restrictions. The main result shows that structural composition of countries plays a prominent role, while heterogeneity is driven by dissimilarities in knowledge bases and innovative efforts across Europe.

This paper examines the politics of open defecation by focusing on everyday intersections of the body and infrastructure in the metabolic city, which produces profoundly unequal opportunities for fulfilling bodily needs. Specifically, it examines how open defecation emerges in Mumbai's informal settlements through everyday embodied experiences, practices and perceptions forged in relation to the materialities of informality and infrastructure. It does so by tracing the micropolitics of provision, access, territoriality and control of sanitation infrastructures; everyday routines and rhythms, both of people and infrastructures; and experiences of disgust and perceptions of dignity. It also examines open defecation as embodied spatial and temporal improvisations in order to investigate the socially differentiated efforts and risks that it entails. More broadly, the paper seeks to deepen understandings of the relationship between the body, infrastructure and the sanitary/unsanitary city.

An evidence-based (EB) approach has been a significant driver in reforming healthcare over the past two decades. This change has extended across a broad range of health professions, including oral healthcare. A key element in achieving an EB approach to oral healthcare is educating our practitioners, both current and future. This involves providing opportunities integrated within simulated and actual clinical settings for practitioners to learn and apply the principles and processes of evidence-based oral healthcare (EBOHC). Therefore, the focus of this discussion will be on ways in which EBOHC and associated research activities can be implemented into curricula, with the aim of improving patient care. This paper will initially define the scope of EBOHC and research, what these involve, why they are important, and issues that we need to manage when implementing EBOHC. This will be followed by a discussion of factors that enable successful implementation of EBOHC and research into curricula. The paper concludes with suggestions on the future of EBOHC and research in curricula.Key recommendations related to curricula include strengthening of the culture of a scientific approach to education and oral healthcare provision; complete integration of EBOHC into the curriculum at all levels; and faculty development to implement EBOHC based on their needs and evidence of effective approaches. Key recommendations to support implementation and maintenance of EBOHC include recognition and funding for high-quality systematic reviews and development of associated methodologies relevant for global environments; building global capacity of EBOHC researchers; research into improving translation of effective interventions into education and healthcare practice, including patient-reported outcomes, safety and harms, understanding and incorporation of patient values into EB decision-making, economic evaluation research specific to oral healthcare and effective methods for changing practitioner (faculty) behaviours; and extend access to synthesized research in 'user friendly' formats and languages tailored to meet users' needs. Realizing these recommendations may help to improve access to effective healthcare as a basic human right.

This paper contextualises the relation between climate change and human migration using the concepts of neoliberalism, sovereignty and otherness. The paper is intended to provide a general account of climate change and migration research, which seeks to extend understanding of the relation beyond a focus on policy and policy-relevant research. The argument is that because the relation between climate change and migration is so vast, touching on so many aspects of life, the debate on climate change and migration needs to be pluralised. This is especially the case given the future-conditional nature of the relation between climate change and migration.

This paper presents an essentially affine model of the term structure of interest rates making use of macroeconomic factors and their long-run expectations. The model extends the approach pioneered by Kozicki and Tinsley (2001) by modelling consistently long-run inflation expectations simultaneously with the term structure. This model thus avoids the standard pre-filtering of long-run expectations, as proposed by Kozicki and Tinsley (2001). Application to the U.S. economy shows the importance of long-run inflation expectations in the modelling of long-term bonds. The paper also provides a macroeconomic interpretation for the factors found in a latent factor model of the term structure. More specifically, we find that the standard "level" factor is highly correlated to long-run inflation expectations, the "slope" factor captures temporary business cycle conditions, while the "curvature" factor represents a clear independent monetary policy factor.

‘Redlining’ is a form of place-based exclusion. It is widely documented in the US, but not in Europe. This paper focuses on a comparative analysis of redlining practices in the two largest cities of the Netherlands: Amsterdam and Rotterdam. It shows that redlining was common practice in Rotterdam in 1999. In 2001, no signs of redlining were found in Rotterdam. However, ‘yellowlining’ (lower loan-to-value ratios) was still common in some parts of Rotterdam. In Amsterdam, no neighbourhoods were faced with redlining in either 1999 or 2001. However, in 1999 some neighbourhoods were yellowlined. This paper aims to get a better understanding of the nature and the institutional context of redlining in the Netherlands by explaining how the differences in redlining practices between Amsterdam and Rotterdam, and between 1999 and 2001, can be explained. The National Mortgage Guarantee as well as socio-historical, and housing and mortgage market differences and changes, are instrumental in explaining these differences in redlining practices.

Professor Sir Alan Peacock has worked in cultural economics for over 35 years and he pioneered much of what is now the core subject matter of the field. This paper traces the development of his theoretical work on the economics of the arts, heritage and broadcasting, and shows how it interacted with his role as adviser to and chairman of several prestigious committees in the cultural sector. 'Subsidising the Arts involves the same kind of issues as subsidising particular industries or services in the economy, however distasteful this may seem to those who are conditioned to think in terms of a moral ordering of consumption expenditure ... Apart from any predisposition of the author to oppose paternalism, the assertion of any imposed value judgements is too easy a way of deriving support for public intervention designed to give the public not what it wants but what it ought to have!' (Peacock, 1969, p. 323). For a minor field of economics, cultural economics - the economics of the arts, heritage and cultural industries - has been blest with the attention of some major players: besides Keynes, Robbins and Baumol, whose contributions are sketched below, Ashenfelter, Boulding, Caves, Feldstein, Galbraith, Rosen, Scherer, Scitovsky and Shubik have all actively engaged in it, and Coase may also be included on account of his work on broadcasting. Some topics in cultural economics, such as museum entry charges, the finance of public service broadcasting and the size of the subsidy to opera, seem to be perennially controversial and the growing interest in cultural industries and the role of copyright look set to experience a similar future. As with other areas of applied economics, such as the economics of education, of the environment and of health, the analytical basis of cultural economics is welfare economics. It is no surprise, therefore, to find Peacock with his combined interest in welfare economics and cultural policy in this august company. Indeed, he may rightly be called primus inter pares, for he has arguably contributed to more areas of cultural economics than any of the others. Alan Peacock has had a long career as an economist, university teacher, university administrator, government adviser and arts administrator. He also has been an active composer and musician. He has continuously worked in cultural economics since the mid-1960s, having a seminal influence on its development, particularly, but by no means only, in the UK; he was in at the start of the subject and is still contributing to it. He has written his autobiography as a cultural economist, Paying the Piper (Peacock, 1993), in which he lays out his lifelong commitment to applying economics to understanding the arts, drawing on his * This paper was originally written for the Luce conference on 'Economists' case for government support of the Arts' organised in 2002 by Neil De Marchi and Crauford Goodwin of Duke University. I am grateful to Alan Peacock for his factual corrections to this article; also to William Baumol, Mark Blaug and Muriel Nissel for their helpful comments on an earlier draft and to three referees for theirs.

We present an analysis of the articles published in the Journal of Management Studies since its inception to assess to what extent JMS has: maintained its leading international ranking; maintained its founding mission as a broad based management journal; and remained a broad based management journal compared to other general management journals. In terms of its impact factor and citations despite reaching a low point in 2001, we find that JMS today ranks higher than it has ever done throughout its 50-year history. From our content analysis covering the life-cycle of JMS, we find four areas have been the most frequently represented, although their relative importance varies between decades: Organizational Management/Behaviour, Strategy, Human Resource Management, and General Management, accounting for 67 per cent of articles published over the period. JMS has strengthened its international author distribution through the increase in authors from the EU especially; the period 2000–04 which saw the predominance of UK authors was an anomaly. There are marked differences between type of article and author country of origin. Our comparative analysis of the word networks between the journals JMS, AMJ, ASQ, and HRM shows that over each decade the papers in the first three normally form a single cluster, indicating that the words used in the papers in the different journals are similar, while papers from HRM often form an outlining group. Notably, in the early 2000s papers in JMS form a distinct cluster, with papers from HRM paralleling the anomaly identified in the content analysis. Overall, JMS has regained its distinctiveness as a broad-based international management journal, not favouring any particular theoretical or empirical approach.