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Valproic acid (VPA) is a teratogenic antiepileptic drug that, when administered during the early stages of pregnancy, can produce alterations in embryo-fetal development, which manifest both at the level of the nervous system and the testicle. However, it has been reported that the administration of vitamin E (VE) could reverse these alterations. The study aimed to determine the protective effect of VE at the testicular level in fetuses and pubertal mice exposed to VPA during the embryonic phase of their development. 30 pregnant adult female mice (Mus musculus) BALB/c strain were used, which were divided into 6 groups. The study included the analysis of male fetuses at 17.5 days post-coital (dpc) and juvenile males at 6 weeks post-natal. Groups 1 and 4 were administered 0.3 mL of physiological solution. Groups 2 and 5 were given 600 mg/kg of VPA (VPA groups), while groups 3 and 6 were given the same dose of VPA supplemented with 200 IU of VE (VPA+VE). The normal and pathological histology of the peritubular compartment of the testis was described. In the VPA groups, degeneration of the peritubular wall, and atrophy of the seminiferous tubules, as well as exfoliation of the germ cells, were evident. On the contrary, in the VPA+VE groups such signs were not observed and the morphology presented a normal appearance with only some focal alterations. These results corroborate the fact that the administration of VE partially counteracts the deleterious effects caused by VPA. [ABSTRACT FROM AUTHOR]

Objective: To determine the effectiveness of vitamin E in nonalcoholic fatty liver disease (NAFLD) among type 2 diabetes patients without advanced fibrosis. Materials and methods: A quasi-experimental analytical study consisting of two groups: an experimental one, which received vitamin E 400 IU in addition to the standard treatment, and a control group, which received only the standard treatment. The study included 71 patients in each group. Both groups underwent liver fibrosis scoring, liver ultrasound and glutamate pyruvate transaminase measurement at study baseline and after six months. Moreover, the Wilcoxon test was used to compare the concentrations of fibrosis score and glutamate pyruvate transaminase values within the same group, and the Mann-Whitney U test was used to evaluate the differences between the experimental and control groups. The Wilcoxon test was also used to compare ultrasound severity. Then, a logistic regression analysis was performed. The information was entered into a data collection sheet using Microsoft Excel; afterwards, a database was coded and created using IBM SPSS Statistics statistical software 23.0. Results: Among the results, it was found that vitamin E was significantly effective in reducing liver fibrosis, transaminase and ultrasound severity scores (Z = -4.727 and p < 0.05). According to the logistic regression analysis, glutamate pyruvate transaminase levels and fibrosis score are not substantially explained by the confounding variables included in the model at 95 % confidence. Conclusions: Vitamin E at a dose of 400 IU given orally for six months is an effective intervention to control the progression of liver disease, which can be quantified by fibrosis score, transaminase reduction and ultrasound assessment after a 6-month follow-up. [ABSTRACT FROM AUTHOR]

Background: There are energy and nutrient recommendations for a healthy population; however, important functions in different health situations are attributed to nutrients such as vitamins D, E, K, E and K. Objective: To explore the effectiveness of dietary doses and supplements of vitamins D, E and K in special conditions of health and disease. Materials and Methods: A document search was carried out in the PubMed, Scopus, Sciencedirect, Lilacs, Scielo and Ebsco databases, and in specialized texts using keywords: "vitamin D", "vitamin E", "vitamin K", "Health", "disease", "nutritional recommendations". Results: There is a significant number of studies and systematic reviews that contribute to the evidence and discussion regarding effect, dose and time, which yielded both positive and null outcomes. Conclusion: The effects of dietary vitamin D in bone health are well documented and its supplementation accompanied by calcium is indicated in population groups at risk for osteoporosis, but not in other clinical conditions. There is insufficient evidence on the benefits of vitamin E in the management or prevention of liver disease, cardiovascular disease, or cancer. Vitamin K could be important in bone health, over other clinical conditions. [ABSTRACT FROM AUTHOR]

Copyright of Revista Argentina de Antropología Biológica is the property of Revista Argentina de Antropologia Biologica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Background: the clinicians rarely have to cope with diseases of nutritional origin and scarcely, although possible, vitamins alterations produce neurological symptoms. Objectives: to show, based on two clinical cases, the neurological symptoms due to liposoluble vitamins alterations, focusing on vitamins E and A. Conclusions: it is important to consider liposoluble vitamin alterations as a cause of neurological symptoms, despite their rarity, after rolling out the most probable entities. [ABSTRACT FROM AUTHOR]

Sinopsis: Objetivo: Poco se conoce sobre la eficacia de productos para la prevención de radiodermatitis, que afecta al 90–95% de las mujeres con cáncer de mama. El uso de antioxidantes es promisorio, sin embargo, poco estudiado. Los autores desarrollaron un protocolo de ensayo clínico para evaluar el efecto potencial de la aplicación de crema con nanopartículas con vitamina E para prevenir radiodermatitis aguda en mujeres con cáncer de mama. Método: El protocolo sugiere que 108 mujeres adultas con cáncer de mama, que estén recibiendo radioterapia, sean incluidas en este ensayo clínico, controlado, aleatorizado y triple ciego, en un hospital oncológico. Se prevé la distribución de pacientes en tres grupos de 36 personas: el grupo A recibirá una crema con nanopartículas lipídicas con vitamina E, el grupo B obtendrá una crema sin nanopartículas ni vitamina E, y el grupo C usará una crema con nanopartículas sin vitamina E. Los resultados primarios evaluarán la incidencia, el grado y el tiempo de surgimiento de la radiodermatitis. Los resultados secundarios se centrarán en la calidad de vida, los síntomas y la temperatura local. Las pacientes serán evaluadas tres veces por semana, desde el inicio de la radioterapia hasta dos semanas después de la última sesión. El presente proyecto fue aprobado por el comité de ética en investigación de las instituciones involucradas. Objective: Little is known about the efficacy of products that aim to prevent radiodermatitis, which affects between 90–95% of women with breast cancer. The use of antioxidants is promising, however, there is a lack of evidence on their effectiveness. Here, the authors present a clinical trial protocol to evaluate the potential effects of applying a nanoparticle cream with vitamin E to prevent radiodermatitis in patients with breast cancer. Method: The protocol recommends that 108 women with breast cancer, who are receiving radiotherapy, be included in a triple-blinded, randomised, controlled study in an oncology hospital. Patients will be divided in three groups of 36 people each: group A will receive a cream with lipid nanoparticles and vitamin E, group B will obtain a cream without nanoparticles or vitamin E, and group C will receive a cream with nanoparticles without vitamin E. The primary endpoints will evaluate the incidence, degree and time of onset of radiodermatitis. The secondary endpoints will focus on quality of life, symptoms and local temperature. Patients will be assessed three times a week, from the start of their radiotherapy treatment to two weeks after the last session. This protocol was approved by the research ethics committee of the institutions involved. [ABSTRACT FROM AUTHOR]

Introduction and Objectives: Adjuvant therapy with vitamins C and E has been proposed to increase standard triple therapy's Helicobacter pylori eradication rate. This study tested this hypothesis in a cohort of patients from the Peruvian Amazon. Material and Methods: We retrospectively evaluated a cohort of 50 patients at Tarapoto Hospital who were treated for H. pylori infections from July to December 2016. Of these, 25 were randomly selected to receive standard triple therapy of 1 g amoxicillin, 500mg clarithromycin and 20mg omeprazole twice a day for 14 days plus adjuvant vitamins C and E. The other 25 only received standard triple therapy. The effectiveness of both treatments was estimated and compared using a general linear regression model using the Poisson family of distributions and log link with H. pylori eradication confirmed by histopathology as the outcome of interest. Results: A comparison of the two groups found no significant differences in their baseline symptoms, histopathological diagnoses, ages (38 ± 11 years vs. 36 ± 10 years) or genders (65%> male vs. 63%> male). A comparison of the effectiveness both treatments found a non-significant increase in eradication rates of 9.5%> (91%> vs. 82%, incidence rate ratio = 1.11; 95%> confidence interval: 0.92 to 1.36). Conclusions: Adjuvant therapy with vitamins C and E may help increase the effectiveness of standard triple therapy for H. pylori in patients in the Peruvian Amazon, although this hypothesis needs to be confirmed in a clinical trial. [ABSTRACT FROM AUTHOR]

Background: The papaya (Carica papaya) contains between 15% and 20% of seeds, which are considered agroindustrial residues that generally have no value and proper management. Objectives: The extraction of oil from papaya seed using supercritical carbon dioxide under different conditions of pressure and temperature was studied in order to evaluate its effect on the yield, fatty acid composition and content of sterols and tocopherols. Also, physicochemical properties were determined as oil quality parameters. Methods: A central composite design using response surface methodology was employed considering pressures between 20-35 MPa and temperatures between 40 and 60 °C, with a flow of CO2 of 30 g/min1 and an extraction time of 150 min. The composition of fatty acids was determined by gas chromatography with flame ionization detector. The sterols and tocopherols were analyzed by gas chromatography coupled with mass spectrometry. The physicochemical properties were performed according to the Colombian Technical Standards and AOAC. Results: Pressure, temperature and their interactions had a statistically significant effect (p<0.05) on the oil yield. The optimum oil yield was 26.3%, obtained at 38.1 MPa and 36°C. The fatty acids identified were: oleic, palmític, linoleic, esteárico, palmitoleico, laurico, linolenic and miristic. Furthermore, the following minority components were identified: campesterol, stigmasterol, β-sitosterol, cycloartenol, sitostenone, squalene and -tocopherol. Conclusions: The supercritical extraction allowed the obtaining of a high yield in oil of papaya seeds, and a selective extraction in fatty acids and squalene, which may be of interest for different industries. [ABSTRACT FROM AUTHOR]

Sonic hedgehog (SHH) is an essential morphogen for the development of neural tube, members and somites. Variations in expression can cause abnormalities in the nervous system. This will produce teratogens, such as valproic acid (VPA), which increases the reactive oxygen species and can be counteracted with the administration of vitamin E (VE). We sought to determine the expression of SHH in the neural tube and spinal cord in mice embryos and fetuses exposed to VPA, VPA + VE and VE. For the study we used 8 groups of female mice (Mus musculus). At day 8 post-coitus (p.c.) the groups were administered as follows: groups 1 and 5, 0.3ml saline; groups 2 and 6, VPA 600 mg/kg; groups 3 and 7, VPA 600 mg / kg + VE 200 IU/kg; groups 4 and 8, VE 200 IU/kg, all treatments were given orally. On the 12th day p.c., groups 1, 2, 3 and 4 were euthanized and the remaining groups at day 17. They were fixed in Bouin solution and included in paraplast; thoracic cross sections were performed, anti-SHH polyclonal antibody (Santa Cruz, H-160, rabbit) dilution 1:100 was used. We described morphology of the positively labeled samples and measured integrated optic density and percentage of immunoreactive area. SHH expression was immunopositive in notochord and floor plate of the neural tube in embryos only 12 day p.c. In the groups treated with VPA + VE and VE immunohistochemistry showed greater intensity and percentage of immunoreactive area compared to those in the group treated with VPA (p ≤ 0.0001) in the floor plate, being similar to the control group. In the notochord, immunoreaction intensity was similar to that shown in the floor plate, with significant differences (p ≤ 0.0001), but the percentage of area showed no differences. The groups at day 17 of gestation were negative for the expression of SHH. VE regulates expression of SHH in neural tube, thus attenuating the effects of VPA. [ABSTRACT FROM AUTHOR]

Valproic Acid (VPA) is the main anticonvulsant used for epilepsy throughout the gestation period. However, when used at early stages of pregnancy, it acts as a tetarogenic agent, causing congenital malformations such as cleft-lip and/or cleft palate, abnormal genital development and spina bifida, being the latter the most frequent. This is the result of the increase of reactive oxygen species, which can be countered with the supplementation of vitamin E. The aim was determine if vitamin E minimizes the damage to the neural tube and spinal cord of mice embryos and fetuses previously exposed to VPA. Eight groups of mice were constituted. Eight days post fertilization, groups 1 and 5 were administered 0,3 ml of saline solution; groups 2 and 6 600mg/Kg of VPA, groups 3 and 7 600mg/Kg of VPA and 200UI/Kg of Vitamin E; groups 4 and 8 200 UI/Kg of Vitamin E. 12 days after fertilization, groups 1, 2, 3 and 4 were euthanized, whereas in the case of the remaining groups, the same process was performed 17 days after fertilization. The embryos were stained with cresyl violet, thus enabling the observation of histological sections at cervical, thoracic and lumbar levels. Groups supplied with vitamin E presented a lower amount of neuroblasts and motoneurons. However, these elements were bigger in size compared to the group treated with VPA (p<0,05), being these results similar to those obtained with the control groups. When comparing the neural tube and spinal cord at different levels (cervical, thoracic and lumbar), no statistically significant differences were found. It was determined that prenatal administration of vitamin E lessens the damage to the neural tube and spinal cord of mice embryos of 12 and 17 days of gestation previously exposed to VPA. [ABSTRACT FROM AUTHOR]

Nonalcoholic Steatohepatitis (NASH) is characterized histologically by the ballooning of hepatocytes, lobular inflammation and steatosis. If this diagnosis is suspected, it is important to exclude other causes of liver damage, especially excessive consumption of alcohol. Nevertheless, to date, a biopsy is the only method available to confirm the diagnosis. Vitamin E should be considered a first-line therapy for treatment of this disease because several clinical studies have shown that a dose of 800 UI/day improves the histology of non-diabetic adults suffering from NASH even when there is no significant impact on fibrosis. These results were confirmed by biopsies. Despite the proven benefits of the use of this drug, it is important to be aware that its use cannot replace changes in diet and exercise but rather should be seen as a complement to these measures. [ABSTRACT FROM AUTHOR]

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Yellow nail syndrome is the triad of pulmonary illness, lymphedema, and characteristic nail changes. In the absence of pulmonary or lymphedematous sequelae, yellow nail syndrome must be included in the differential of nail disorders and is often a diagnosis of exclusion. Nail pathology is likely caused by lymphatic vessel abnormalities, but the exact mechanism remains unclear. Sclerosis of the nail stroma and accumulated biochemical compounds that cause lymphatic obstruction may offer a possible explanation. The most frequently cited treatment for nail changes in yellow nail syndrome is vitamin E therapy, though reports of success vary and evidence is lacking for other treatment options. Spontaneous nail recovery after the resolution of pulmonary symptoms or other underlying disorders is a more frequently reported occurrence. Several other medical conditions have been associated with the disorder and have therefore, influenced treatment decisions. While adult yellow nail syndrome is considered a sporadic entity, pediatric cases show genetic inheritance, furthering confusing the etiology of this disorder. [ABSTRACT FROM AUTHOR]

Two experiments were carried out to evaluate selenium and vitamin E (Se-VE) in Pelibuey ewes. The application of Se-VE took place two days before progesterone (P) was no longer provided. The onset of estrus, the number of corpus luteum, fertility, lambing, fecundity and prolificacy were recorded. In the first experiment, 125 females were used and randomly assigned to one of eight treatments. P (T1; n = 12), P + Se-VE (T2; n = 12), P + Equine chorionic gonadotropin (eCG; T3; n = 12), P + Directed feeding (AD; T4; n = 12), P + Se-VE + eCG (T5; n = 12), P + Se-VE + AD (T6; n = 12), P + eCG + AD (T7; n = 12) and P + Se-VE + eCG + AD (T8; n = 12). Later, a ninth treatment was added (T9, Without drugs (SF), n = 29). In the second experiment, 178 females were used and randomly assigned to one of the following treatments. P (T1; n = 62), P + Se-VE + eCG (T2; n = 62) and SF (T3; n = 54). Data were analysed with a Chi-square test for variables in percentages, and with an analysis of variance for quantitative variables. In the first experiment, the beginning of estrus was different (p ≤ 0.05) for T3 and T5. T9 was different from the other treatments (p ≤ 0.05) for fertility, lambing and fecundity. In the second experiment, T2 was different (p ≤ 0.05) for the onset of estrus. T2 and T3 were different (p ≤ 0.05) for fertility, lambing and fecundity. It is suggested that the administration of Se-VE + eCG may be used as a strategy to improve estrus synchronisation and to homogenise its appearance in less time, without decreasing the reproductive efficiency of the Pelibuey ewes. [ABSTRACT FROM AUTHOR]

Chicken fat, compared with the beef or pork, has a low lipid profile amount of saturated fat and a good balance of family ω -6 and ω -3 recommended in a healthy diet. Such fat composition affects the animal's flesh, promoting oxidation. Despite this, the poultry industry has not taken the necessary measures to counteract this adverse effect. It is located in the scientific literature involving various references administration of alpha- lipoic acid (ALA) in the diet of broilers both individually and in synergy with vitamin E, enhancing the oxidative stability of the meat, which discloses the importance of natural antioxidants such as alternate route to improve the quality of meat products. [ABSTRACT FROM AUTHOR]

Copyright of MedULA is the property of Facultad de Medicina, Universidad de los Andes, Venezuela and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: An increase in the oxidative stress and a decrease in the antioxidant levels have been described in diabetic patients, that have been related with the etiopathogenesis of diabetes and its chronic complications. Methods: We performed a non-systematic review to evaluate the relationship between oxidative stress and diabetes, and the possible effects of antioxidants in the prevention and treatment of diabetes and its complications. Results: The intervention studies including different antioxidants have not demonstrated any beneficial effect on cardiovascular and global morbimortality in different populations, including diabetic patients. Neither of these studies has demonstrated a beneficial effect of antioxidant supplementation on the prevention of diabetes. According to these studies, these substances can decrease lipid peroxidation, LDL-cholesterol particles oxidation and improve endothelial function and endothelial-dependent vasodilatation, without significant improvement in the metabolic control of these patients. Conclusions: The current evidence does not support the use of high doses of antioxidants on the prevention and treatment of diabetes and its complications. [ABSTRACT FROM AUTHOR]

Copyright of Revista Médica de Risaralda is the property of Universidad Tecnologica de Pereira and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Se evaluó el efecto de una terapia antioxidante basada en inyecciones de selenio y vitamina E, administradas antes y después del parto, en la incidencia de patologías uterinas y fertilidad en vacas Holstein. Se utilizaron 353 vacas, las cuales se asignaron al azar a tres grupos: Grupo pre-posparto (n = 122), las vacas recibieron una inyección sc de 50 mg de selenio y 680 UI de vitamina E (10 mL de Mu-Se) los días 60 y 21 preparto y 30 y 90 posparto; Grupo preparto (n = 117), las vacas recibieron una inyección similar al grupo anterior 21 días antes del parto; Grupo testigo (n = 114), los animales recibieron una inyección subcutánea de 10 mL de solución salina fisiológica los días 60 y 21 preparto, y 30 y 90 posparto. La incidencia de retención placentaria en el Grupo testigo (20.1%) fue similar (P > 0.05) al Grupo preparto (12.8%), pero difi rió (P < 0.05) del Grupo pre-posparto (6.5%). La proporción de vacas con metritis hemorrágica fue similar entre grupos (8.7%; P > 0.05). El porcentaje de vacas con metritis purulenta en el Grupo testigo (37.7%) fue igual (P > 0.05) al Grupo preparto (33.3%), pero se redujo (P < 0.05) en el Grupo pre-posparto (23.7%). La proporción global de vacas con cualquiera de las patologías evaluadas fue similar (P > 0.05) entre las vacas de los grupos testigo (44.7%) y preparto (40.1%), pero fue menor (P < 0.05) en el Grupo pre-posparto (27%). El Grupo pre-posparto tuvo mayor (P < 0.08) tasa de gestación (70%) a los 150 días posparto que el testigo (58.9%). Se concluye que la administración de selenio y vitamina E los días 60 y 21 antes del parto y 30 y 90 posparto, reduce las patologías uterinas y mejora la tasa de gestación al día 150 posparto en vacas Holstein. [ABSTRACT FROM AUTHOR]

Copyright of Archivos Latinoamericanos de Nutrición is the property of Sociedad Latinoamericana de Nutricion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Antioxidants have been used to slow down or inhibit atherosclerosis. The objective of the present study was to compare the effect of pinus maritime, and of vitamins C and E, separately and combined, on serum concentration of oxLDL, E-selectin, IL-6, CRP and on the formation of aortic lesions in rabbits. 84 rabbits were studied: Group 1: commercial rabbit food (CRF) and vegetables. Group 2: Egg and (CRF). Group 3: Egg, (CRF) and Pinus maritime. Group 4: Egg, (CRF) and vitamin C. Group 5: Egg, (CRF) and vitamin E. Group 6: Egg, (CRF), Pinus maritime and vitamin C. Group 7: Egg, (CRF), Pinus maritime and vitamin E. The experiment lasted 12 weeks. Lipid profile, oxLDL, E-selectin, IL-6, vitamin E, vitamin C, PCR and histological study of rabbits' aorta were performed. Antioxidant supplement decreased oxLDL, E-selectine, IL-6 (p<0,05) and inhibited aortic lesions. In conclusion, antioxidants were effective in slowing down inflammation and oxidation markers, and the formation and progression of atheroma. [ABSTRACT FROM AUTHOR]

Background: Supplementation with vitamin E may antagonize vitamin E in healthy adults, but it is unclear whether intake of vitamin E decreases the risk of venous thromboembolism (VTE). Methods and results: The Women's Health Study randomized 39,876 women = 45 years of age to receive 600 IU of natural source vitamin E or placebo on alternate days. Before randomization, 26,779 participants gave blood samples, which were used to determine factor V Leiden, G20210 A prothrombin, and 677C>T MTHFR polymorphisms. Documented VTE (including deep vein thrombosis or pulmonary embolism) and unprovoked VTE (no recent surgery, trauma, or cancer diagnosis) were prospectively evaluated, secondary end points of the trial. During a median follow-up period of 10.2 years, VTE occurred in 482 women: 213 in the vitamin E group and 269 in the placebo group, a significant 21% hazard reduction (relative hazard, 0.79; 95% CI, 0.66 to 0.94; p = 0.010). For unprovoked VTE, the hazard reduction was 27% (relative hazard, 0.73; 95% CI, 0.57 to 0.94; p = 0.016). In subgroup analyses, the 3% of participants who reported VTE before randomization had a 44% hazard reduction (relative hazard, 0.56; 95% CI, 0.31 to 1.00; p = 0.048), whereas women without prior VTE had an 18% hazard reduction (relative hazard 0.82; 95% CI, 0.68 to 0.99; p = 0.040). Women with either factor V Leiden of the prothrombin mutation had a 49% hazard reduction associated with vitamin E treatment (relative hazard, 0.51; 95% CI, 0.30 to 0.87; p = 0.014). Conclusions: These data suggest that supplementation with vitamin E may reduce the risk of VTE in women, and those with a prior history or genetic predisposition may particularly benefit. [ABSTRACT FROM AUTHOR]

An interest in vitamin E has increased in recent years due to its potent antioxidant properties and its role in preventing age-related diseases, cardiovascular diseases or Alzheimer. This work describes the biogenesis, bioavailability, nutritional requirements, activity and properties of vitamin E. Vegetable oils constitute one of the main sources of vitamin E dietary intake and an extensive bibliographic revision of this vitamin in vegetable oils is carried out from four points of view: antioxidant properties, health benefits, effects of external agents and effects of processing on vitamin E content and analytical techniques used for its analysis. [ABSTRACT FROM AUTHOR]

Introduction. The transplant of fat has been in use since his first report in the year 1800, for obliterating faults orbitalis, in the treatment of the atrophy hemifacial and for the increase of small mammary glands. Nowadays with the method of lipoinjection the above mentioned technique is used for the alteration of faults of contour secondary to congenital, traumatic pathology or iatrogenic. Objective. To demonstrate if the addition of vitamin E to the adipose tissue grafted by means of lipoinjection increases the survival of the graft for the antioxidant properties of the vitamin E. Material and method. An experimental study realized from January 16 to March 30, 2007 in the Bioterio of the Hospital Central Militar, in rates type Winstar; there was analyzed the quantity of adipose tissue grafted on 10 rates by the technique of lipoinjection and in 10 rates by addition of vitamin E in grafted tissue. Results. To the experimental group of 10 rates was added vitamin E to the adipose graft. One month later there took biopsy of the grafted area and there measured up the adipose obtained tissue, being in both groups of 10 mm. The statistical analysis with the test T de Student obtained a value of p = 0.3466. By what the difference is considered to be statistically not significant. Discussion. The quantity of adipose grafted tissue obtained by means of the skill of lipoinjection in gluteal muscle of the rate was the same when it was grafted alone as when vitamin E was added to the tissue. Conclusions. This find does not support the theory of which the addition of antioxidant helps to improve the survival of the graft. [ABSTRACT FROM AUTHOR]

Introducción: Los efectos secundarios a fármacos antiepilépticos (FAE) son factores limitantes en la adherencia al tratamiento. Entre ellos, se encuentra la alopecia. Uno de los FAE más utilizados es el ácido valproico (VPA), el que causa pérdida de cabello, siendo más frecuente a dosis más altas, tratamientos crónicos y/o en mujeres. Para el desarrollo de la piel y los folículos pilosos, es necesaria la expresión Sonic hedgehog (Shh). El VPA causa un aumento de especies reactivas de oxígeno, lo que ocasiona alopecia, pudiendo contrarrestrarse con vitamina E (VE). Objetivo: Determinar la inmunoexpresión de Shh en epidermis y folículos pilosos en fetos de ratones expuestos a VPA, VPA+VE y VE. Material y método: Se conformaron 4 grupos de ratones hembra gestantes (Mus musculus) BALB/c. A los 8,5 días post-coito (dpc) se administró al grupo control suero fisiológico 0,3 ml, grupo VPA 600 mg/kg, grupo VPA 600 mg/kg + VE 200 UI/kg y grupo VE 200 UI/kg, vía oral. A los 17,5 dpc, se realizó la eutanasia. Los fetos fueron fijados en formalina al 10% tamponada en PBS e incluidos en paraplast. Se cortaron transversalmente a nivel torácico. Se realizó inmunohistoquímica con anticuerpo policlonal Shh (scbt, H-160, conejo), dilución 1:100. Se describió la morfología de las muestras marcadas positivamente, se midió la densidad óptica integrada y porcentaje de área inmunoreactiva en epidermis y folículos pilosos en desarrollo. Resultados: La inmunotinción de Shh fue positiva en epidermis y folículos pilosos en desarrollo. Al cuantificar la densidad óptica integrada, el grupo VPA presentó una menor intensidad de inmunoreacción en comparación a los grupos control, VPA+VE y VE (p>0,0001). En cuanto al porcentaje de área inmunopositiva, el grupo VPA evidenció un menor porcentaje de inmunoreacción en comparación al grupo control (p>0,0001), grupo VPA+VE (p>0,001) y grupo VE (p>0,005). Entre los grupos control, VPA+VE y VE no hubo diferencias significativas. Conclusiones: La vitamina E actúa como agente protector ante la alopecia inducida por VPA. [ABSTRACT FROM AUTHOR]

Objetivo: determinar la efectividad atribuible al tratamiento coadyuvante con vitaminas C y E para H. pylori en una cohorte de pacientes de la amazonía peruana tratados con la terapia triple estándar (TTE). Métodos: estudio de cohortes que evaluó retrospectivamente una cohorte de 50 pacientes infectados con H. pylori tratado con TTE (Amoxicilina 1g BID, claritromicina 500 mg BID y omeprazol 20mg BID por 14 días) en el Hospital de Tarapoto en octubre-diciembre 2016. La mitad fueron expuestos al tratamiento coadyuvante con vitaminas C y E y la otra mitad fue tomada al azar (1:1) entre los no expuestos a la terapia adyuvante. Con los datos de sus historias clínicas y teniendo como variable desenlace la erradicación del H. pylori confirmada por histopatología, se estimó y comparó la efectividad de ambos tratamientos utilizando un modelo regresión general lineal con familia Poisson y link log. En todos los casos se controló la adherencia al tratamiento con el conteo de tabletas. Resultados: en el análisis de línea de base no se encontraron diferencias significativas entre los expuestos y no expuestos incluyendo variables como edad (38±11 vs. 36±10 años), sexo masculino (65% vs. 63%), síntomas principales (anorexia, 13% vs. 4%; dolor abdominal, 43% vs. 40%; náuseas, 4% vs. 9%; pirosis, 17% vs. 18%; regurgitación, 43% vs. 40%) y diagnóstico histopatológico basal (gastritis antral, 54% vs. 43%; dolor abdominal, 18% vs. 13%; pangastritis, 27% vs. 43%). Al término del tratamiento se encontró un incrementó no significativo en las tasas de erradicación en los expuestos con respecto a los no expuestos de un 9,5% (91% vs. 82%; riesgo relativo [RR]=1,11; Intervalo de confianza al 95% [IC95%]: 0,92-1,36). Sin embargo, sí se encontró una asociación significativa entre las tasas de erradicación y el sexo de los pacientes (masculino vs. femenino, 100% vs. 79%; RR=0,79; IC95%: 0,66-9,95). Conclusiones: el tratamiento coadyuvante con vitaminas C y E podría ayudar a incrementar la efectividad atribuible a la TTE para H. pylori en los pacientes de la amazonía peruana; sin embargo, para demostrar ello se recomienda realizar un ensayo clínico considerando género como un potencial modificador de efecto. [ABSTRACT FROM AUTHOR]