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Antecedentes: En Chile el parto prematuro es la principal causa de morbilidad y mortalidad perinatal. Objetivo: Evaluar la utilidad clínica de la longitud cervical y la detección de fibronectina, en la predicción de parto prematuro. Método: Estudio observacional prospectivo, de corte transversal en 86 pacientes que consultaron por síntomas de parto prematuro (SPP), con membranas indemnes y edad gestacional entre las 22 y 34 semanas. El grupo estudio formado por gestantes con parto prematuro dentro de los 7 días. Al ingreso se tomó muestra cervical para fibronectina y se midió longitud cervical mediante ultrasonografía transvaginal. Resultados: De las 86 gestantes estudiadas, en 13 (15%) se produjo el parto dentro de los 7 días. La curva ROC mostró un área bajo la curva para longitud cervical de 0,475 y sensibilidad 31% (4/13), especificidad 96% (70/73), valor predictivo positivo 57% (4/7) y valor predictivo negativo 89% (70/79), riesgo relativo positivo 5,0 y riesgo relativo negativo 0,47 (p=0,014). El área bajo la curva para fibronectina fue 0,92 con una sensibilidad 77% (10/13), especificidad 90% (66/73), valor predictivo positivo (10/17) 59% y valor predictivo negativo 96% (66/69), riesgo relativo positivo 13,48 y riesgo relativo negativo 0,43 (pBackground: In Chile the preterm labor is the main cause of perinatal morbidity and mortality. Objective: To evalúate the clinical utility of the cervical length and fibronectin determination in predicting preterm delivery. Method: A prospective observational and transactional study was made, in 86 patients with preterm labor symptoms and gestational age between 22 and 34 weeks. The study group included patients with labor and delivery within a week of admission. From each patient a cervico-vaginal specimen was obtained to measure fibronectin and transvaginal ultrasonographic evaluation of the uterine cervix. Results: From 86 patients admitted to the study, thirteen had preterm labor (15%). The ROC curve showed an área under curve for cervical length of 0.475 and sensitivity 31 % (4/13), specificity 96% (70/73), positive predictive valué 57%(4/13), negative predictive valué 88% (70/79), positive relative risk was 5.0, and the negative relative risk 0.47 (p=0.014); for fibronectin was 0.92 and sensitivity 77% (10/13), specificity 90% (66/73), positive predictive valué 59% (10/17), negative predictive valué 96% (66/69), positive relative riskof 13.48, negative relative risk 0.43 (p=0.014). Conclusión: In patients with premature labor symptoms, the cervical lengths none shortened and negative fibronectin result were associated with a low risk of having a preterm labor. Positive fibronectin was a better predictor of premature birth in a week of admission and the cervical length was the best in ruling out the occurrence of a premature birth

Se analizan las cordocentesis efectuadas en el Servicio en un lapso de 11 años. Se realizaron 30 procedimientos. Quince en 5 pacientes RhD (-) severamente sensibilizadas, siendo sometidas a transfusiones intrauterinas 4 de ellas y obteniéndose la sobrevida de 4 fetos, 2 de ellos hidrópicos al momento de su ingreso. Además, se realizaron cordocentesis con fines diagnósticos en 9 pacientes con fetos hidrópicos y 2 con fetos malformados. Se encontró 3 fetos con anemia y dos fetos con infección a citomegalovirus en 8 pacientes con fetos hidrópicos. En otras 4 pacientes, dos con fetos hidrópicos y dos con fetos malformados se realizó además estudio genético y se encontró triploidia en un feto hidrópico. Se concluye que la cordocentesis es un excelente procedimiento diagnóstico y terapéuticoThirty cordocentesis that were made in our hospital in a period of eleven years are analyzed. Fifteen procedures were made in 5 pregnant patients, complicated by severe red cell isoimmunization. Three fetus were hydropic at the first scan. Intravascular fetal blood transfusions were performed in these patients, and 4 fetus survival after birth. Fetal blood sampling has been used in the prenatal dianosis of cytomegalovirus in two cases and anaemia in there cases, in eight patients with nonimmunological fetal hydrops. Karyotyping were performed in another four patients with nonimmunological fetal hydrops or a fetal malformation, and in one case was identified a triploidia. It is concludes that cordocentesis is an excellent diagnostic and therapeutic procedure

Reliability (accuracy, consistency and reproducibility) is a psychometric property, which is related to the absence of measurement error, or, to the degree of consistency and stability of the scores obtained through successive measurement processes with the same instrument. Thus a greater variability of results will lower the accuracy or reliability of instrument used, fact that is transverse from the laboratory to the clinical practice. It is determined by applying the reliability coefficient, which is the correlation between the scores obtained by the subjects in two parallel forms of a test. Assuming that the two forms of the test are parallel (measure the same), the scores of the subjects under study should be the same in both applications. In this way, when the correlation is 1, the reliability or precision is maximum. On the other hand, reliability could be influenced by the observer (the one that measures), the measuring instrument (by that with which it is measured), and by the observed (by what is measured). Therefore, the variability of each of these components must be taken into account when planning the measurement of the variable under study, in such a way to reduce measurement biases as much as possible. The most common ways to determine reliability are the models of parallel forms, test-retest and two halves. This manuscript focuses on the concepts of measurement and the various statistical techniques used for this, as a step prior to application in the clinic. Therefore, the aim of this manuscript is to generate a consultation document related to the reliability or reproducibility of the measurement process.

Unlabelled: This article introduces the socio-demographic characteristics of psychosexual development and sexual crimes in men deprived of liberty for such crimes who are doing time in a Manizales prison (Colombia) in 2011. It also describes the differences between abusers of individuals under 12 years of age or who are 12 years old, and abusers of individuals over that age., Methodology: This is a descriptive, retrospective study performed by simple random sampling. It consisted of semi-structured interviews in which socio-demographic characteristics, psychosexual development, characteristics of crime, and prevalence of mental disorders were analyzed in a sample of 80 inmates convicted of sexual offenses at the Medium-security Pentientiary center in the city of Manizales. Univariate and bivariate analysis were performed using the χ(2) test and the logistic regression analysis with variables showing statistical significance in the bivariate analysis., Results: It was found that convicted sex offenders belong to lower socioeconomic levels, have low educational levels, and did not receive any sexual education. Such findings become more relevant when the crimes in questions are committed against 12-year-olders or children under this age., Conclusions: The lack of sexual education, low educational levels and lower socioeconomic levels are associated factors in the case of sexual offenses. It is important for society (particularly health-care institutions) to find additional measures for the criminalization of such behaviors in order to achieve a better control of the problem., (Copyright © 2013 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.)

Background: The identification of clinical and pathological forms of Creutzfeldt Jakob Disease (CJD) started with the first cases of the disease. Genetic and biomolecular prion status assessment are allowing now a better classification., Aim: To identify the clinical forms of the disease that exist in Chile, based on clinical and neuropathological data., Patients and Methods: Review of records of 40 patients with CJD in whom a complete history, clinical details and neuropathological studies were available. Clinical aspects were grouped into five categories: behavioral and cognitive changes, sleep and alertness, visual impairment, motor disturbances, myoclonus and epilepsy. The neuropathological examination in each case allowed us to evaluate the damage of 13 areas of the central nervous system., Results: Five forms of CJD were identified. The classic form was present in 28 patients (70%), the Heidenhain form was present in five (12.5%), the ataxic form in four (10%), the form with Kuru plaques in two (5%) and the Vacuolar was present in one patient (2.5%)., Conclusions: The variety and forms of CJD in Chile do not differ substantially from those found abroad.

Aim: The aim of this study was to survey the information available regarding the N400 component of event related potentials (ERP) as an electrophysiological measure of semantic processing., Development: The N400 component of ERP is characterised, the advantages and disadvantages of studies that use this type of electrophysiological measures are presented, and the main findings of the experiments conducted in recent years to establish how N400 is related to linguistic processes are analysed. We also present some of the ways its study can be applied to understanding the brain processes underlying dementias, and especially Alzheimer s disease. The value of this component of ERP in the scientific study of mental processes is clearly illustrated., Conclusions: Electrophysiological measures of ERP are a very promising tool for the study of the cognitive processes that sustain the understanding and organisation of language and memory. ERP are changes in voltage that are registered on the scalp and which are synchronised with an observable (sensory, motor or cognitive) event. They are a non invasive method of monitoring brain processes in real time and as such can be used to obtain electrophysiological evidence of brain functioning and of psychological processes. The N400 component of ERP has been linked mainly to language processing and has been recorded in association with examples of semantic incongruence found in sentences, words or visually presented figures.

With the massive vaccination campaigns with the inactivated poliomyelitis vaccine starting in 1955 and its oral presentation in 1961, this disease has been controlled in many countries. However, wild polio virus is still transmitted in many developing countries. The study reported in this article had the objectives of estimating the prevalence of antibodies against polio for three types of virus (1, 2 and 3) in the population from 12 to 59 months of age in Mexico and determining the factors associated with the absence of immunity. One section of the National Seroepidemiology Survey (NSS), a study with a representative sample of the Mexican population, included the analysis of 5,260 blood samples for polio seropositivity. These samples were processed using the technique of plaque-reduction-neutralization, with the cut-off for positive titer values at 1:8. The national immunity levels reported for the three types of polio virus were: type 1 (89.8%); type 2 (97.6%); and type 3 (85.4%). The state with the lowest seroprevalence was Campeche, with 59.7 per cent, and the highest observed was Baja California Sur, with 93.0 per cent. The NSS also showed that the immunity level increases with age. There were some differences observed by place of residence; seroprevalences were higher in the urban areas (type one, 93.4%; type two, 98.5% and type three, 88.2%) than in the rural zones (86.6%, 96.8% and 82.9%, respectively). As expected, previous vaccination with three or more doses, referred verbally by the parent or guardian of the child, was associated with higher positivity.(ABSTRACT TRUNCATED AT 250 WORDS)

Measles is an illness of universal distribution and great social impact. According to the WHO, the annual deaths due to this disease amount to more than a million children in the world. The objectives of this paper are to estimate the seroprevalence of titer of antibodies to measles in the population of 12 to 59 months of age in Mexico and identify the determinants of the immunity state. From the National Seroepidemiology Survey, 5,232 blood samples of children between 12 and 59 months of age, were analyzed, their blood samples were considered positive when the antibody titers were greater or equal to 1:4, tested by hemagglutination inhibition using sensitized erythrocytes. The National seroprevalence was 76.2 per cent. By age group, an increment in positive level was observed age increased. The seroprevalence was 56 per cent in children of 12 to 24 month and 82 per cent for children 48 to 59 month of age. The history of vaccination was obtained verbally; 62.5 per cent of seropositive didn't have vaccination history and 82.5 per cent were of those vaccinated were positive. By place of residence, at rural level (populations less than 2,500 inhabitants) 74 per cent positives, compared to 79 per cent in children of urban areas. All risk factor were significant, based on a univariate analysis, being the one with greatest risk those with negative vaccine history and children of one year of age. The efficiency of the vaccine estimation was of 63.6 per cent. Risk factors related to the vinculation of immunity protection to measles or seropositives were age, and verbal history of vaccination.